AACR Annual Meeting, April 16-20, 2016 Schedule of Winship Poster and Speaker Sessions Sunday, April 17, 2016 Location Section 24 Section 34 Time 1:00pm-5:00pm 1:00pm-5:00pm Presentation Room 291, Morial Convention Center 2:45pm-3:10pm Presentation # Poster # Author(s) 515 2 Xu Wang/Nabil Saba 780 9 Daniel Brat Sagar Lonial Title (Click on presentation title for detail) Survivin contributes to radiation resistance in head and neck cancer through regulation of DNA damage repair Multi-omic profiling of gliomas reveals distinct DNA methylation changes at tumor recurrence The importance of plasma cell biology in treating newly diagnosed multiple myeloma Monday, April 18, 2016 Location Section 11 Section 35 Section 33 Section 37 Section 20 Section 21 Section 5 Section 4 Section 34 Section 4 Section 17 Section 4 Section 9 Section 31 Section 15 Section 36 Time Presentation # Poster # Author(s) 8:00am-12:00pm LB-101 1 You-Take Oh 8:00am-12:00pm 1758 25 Caroline Um 8:00am-12:00pm 1701 28 Uma Krishnamurti 8:00am-12:00pm 1791 4 Veronika Fedirko 8:00am-12:00pm 1360 19 Omer Kucuk 8:00am-12:00pm 1388 19 Keerthi Gogineni 8:00am-12:00pm 1034 4 Gabriela Oprea-Ilies 8:00am-12:00pm 1008 8 Gabriela Oprea-Ilies 8:00am-12:00pm 2516 5 Daniel Brat 1:00pm-5:00pm 1866 4 Dongsheng Wang/Nabil Saba 1:00pm-5:00pm 2105 3 Puyu Shi 1:00pm-5:00pm 1892 30 MaKendra Umstead 1:00pm-5:00pm 2023 25 Birdal Bilir 1:00pm-5:00pm 2451 14 Abhinav Dey 1:00pm-5:00pm 2079 28 Lily Yang 1:00pm-5:00pm 2580 9 Lisa Flowers Title (Click on presentation title for detail) The expression of death receptor 4 is positively regulated by MEK/ERK signaling and suppressed upon MEK inhibition Circulating insulin-like growth factors: Correlates and responses to calcium supplementation in colorectal adenoma patients CCR6 associates with colon cancer metastasis Effects of calcium and vitamin D supplementation on circulating markers of inflammation Genistein-AR antagonist conjugate potently induce growth arrest in both androgen dependent and independent prostate cancer cell lines Multi-template analysis in metastatic breast cancer blood samples Leptin induces early onset and aggressiveness of pancreatic cancer Leptin-induced NILCO in endometrial cancer is linked to obesity TRIM8 modulates stem-like cells in glioblastoma HER3 targeting sensitizes HNSCC to cetuximab - evidence from cell line and patient derived xenograft (PDX) models c-Met hyperactivation is an universal resistance mechanism to both first and third generation EGFR inhibitors Investigating the role of Aurora Kinase A as a positive regulator of MAPK signaling SOX4 is essential for PTEN-mediated prostate tumorigenesis in vivo Cancer stem cell survival postradiation in medulloblastomas requires YAP, YB1, and IGF2 IONP-LPrA2 and PEG-LPrA2 therapies for triple negative breast cancer Optimizing cervical cancer screening for HIV-infected women: A risk-based approach Location Section 3 Section 24 Section 21 Section 6 Section 2 Section 21 Time Presentation # Poster # Author(s) 8:00am-12:00pm 2757 15 Gou Chen 8:00am-12:00pm 3196 3 Laura Metrock 8:00am-12:00pm 3114 9 Omer Kucuk/Nabil Saba 1:00pm-5:00pm 3607 6 Debra Saxe 1:00pm-5:00pm 3502 12 Abu Anisuzzaman 1:00pm-5:00pm 3903 8 Mohammad Aminur Rahman Section 14 Section 36 Section 37 Section 36 Section 29 1:00pm-5:00pm 1:00pm-5:00pm 1:00pm-5:00pm 1:00pm-5:00pm 1:00pm-5:00pm You-Take Oh Veronika Fedirko Ashley Holmes Roberd Bostick David Rimland Title (Click on presentation title for detail) Mcl-1 dictates DNA double-strand break repair pathway choice STAT3 inhibitor WP1066 as a novel therapeutic for medulloblastoma Soy isoflavones modulate global methylation in head and neck squamous cell carcinoma (HNSCC) An evaluation of NGS to identify gene fusions using RNA from FFPE solid tumor samples Combination of BKM120 and erlotinib in squamous cell carcinoma of the head and neck: mechanism of in vitro and in vivo synergy Optimizing the antitumor efficacy of AuNR-assisted plasmonic photothermal therapy and its molecular impact B-Raf inhibition-induced paradoxical activation of MEK/ERK signaling enhances DR5 expression and DR5 activation-induced apoptosis in Ras-mutant cancer cells Mitochodrial D-loop polymorphisms are associated with colorectal adenoma risk Associations of dietary inflammation scores with incident, sporadic adenoma Mitochondrial DNA copy number, urinary isoprostanes and colorectal cancer risk Multiplicative interaction between HIV infection status and FIB-4 in prediction of hepatocellular carcinoma risk Tuesday, April 19, 2016 3725 4292 4319 4281 4308 18 12 10 1 28 Clinical Trials Plenary Session Room 391, Morial Convention Center 10:30am-10:48am CT096 Ragini Kudchadkar Clinical activity, immune and viral correlates of PD-1 blockade with pembrolizumab as first systemic therapy in patients with advanced Merkel cell carcinoma Room 391, Morial Convention Center 11:44am-12:02pm CT099 Nabil Saba Nivolumab (nivo) vs investigator’s choice (IC) for recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): CheckMate-141 Alice Kamphorst Rescue of exhausted CD8 T cells by PD-1 targeted therapies is CD28-dependent Minisymposium N.O. Theater C, Morial Convention Ctr. 3:30pm-5:30pm 4359 Invited Speaker Room 283, Morial Convention Center 3:30pm-5:30pm Suresh Ramalingam New Drugs: A Review of Recent Breakthrough Therapies Wednesday, April 20, 2016 Location Section 11 Section 18 Section 11 Section 2 Time Presentation # Poster # Author 7:30am-11:00am LB-348 12 Melissa Gilbert-Ross 7:30am-11:00am 4770 21 Rui Jin 7:30am-11:00am LB-355 19 Jessica Konen 7:30am-11:00am 4416 16 Ganji Purnachandra Nagaraju Title (Click on presentation title for detail) Developing a personalized anti-metastatic therapy to treat KRAS, LKB1-mutant lung adenocarcinoma The regulation of pre-ribosomal RNA synthesis by LKB1 Image-guided genomics reveals a symbiotic relationship between heterogeneous phenotypes in collective cancer invasion Combination of HSP90 and proteasome inhibitor is effective in pancreatic cancer Section 20 7:30am-11:00am Tolfenamic acid and curcumin treatment induces pancreatic cancer cell growth inhibition via suppressing Sp1 expression, NF-kB translocation to nucleus 4818 13 Bassel El-Rayes