A*STAR Annual Report 2010/11 S. 35 of 2011 Presented to Parliament pursuant to Statute. Ordered by Parliament to lie upon the Table: 25 August 2011 AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ANNUAL REPORT APR 2010 – MAR 2011 AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ANNUAL REPORT FOR THE YEAR ENDED 31 MARCH 2011 In the opinion of the directors, the annual report of the Agency for Science, Technology and Research (A*STAR) is drawn up so as to present fairly the state of affairs of A*STAR as at 31 March 2011. On behalf of the Board of Directors, Lim Chuan Poh Low Teck Seng Chairman Managing Director 30 Jun 11 30 Jun 11 1 ORGANISATION DETAILS Board Secretary Ms Tricia Huang Director Planning & Policy Department Agency for Science, Technology and Research Address 1 Fusionopolis Way, #20-10 Connexis North Singapore 138632 Telephone 68266111 Fax 67771711 Email Tricia_HUANG@a-star.edu.sg 2 CONTENTS Introduction to A*STAR 4 Board members 5 Key management personnel 7 Organisation structure 8 Major shareholder of subsidiary companies 9 Exploit Technologies Pte Ltd List of A*STAR research institutes, consortia & centres 10 Highlights of key accomplishments 11 Highlights of the year in review 14 Highlights of scientific breakthroughs in A*STAR research 22 institutes, consortia & centres Highlights of spin-off companies and commercialisation of 25 A*STAR technologies Highlights of partnerships with research institutes and industry Outlook for the next fiscal year 26 28 Financial Statements 3 AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH The Mission of the Agency for Science, Technology and Research (A*STAR) is to foster world-class scientific research and talent for a vibrant knowledge-based Singapore. Fulfilling our mission successfully will allow us to realise our Vision of a prosperous and vibrant Singapore built upon a knowledge-based economy. A*STAR makes use of three broad strategies to carry out our mission. This is A*STAR‘s ―3Cs‖ strategy. Firstly, we contribute to Human Capital Development by promoting manpower training and development in the areas of science, engineering and technology, and by undertaking the promotion of science and technology to increase public awareness and understanding of the importance of science and technology in Singapore. Secondly, we contribute to Intellectual Capital Development that enhances and strengthens knowledge-creation and innovative capability for the country. We do this by directing and undertaking research and development in the areas of science and technology in our Research Institutes (RIs), and by providing extramural research grants to the larger research community in Singapore. Thirdly, we contribute to Industrial Capital Development by promoting the commercial application of scientific knowledge and technology in Singapore. We do this through industry engagement and collaboration, R&D investment promotion, and active commercialisation of the intellectual property we hold. A*STAR‘s Corporate Values are : Action, Speed, Teamwork, Agility, Resolve and Integrity 4 BOARD MEMBERS Chairman Mr Lim Chuan Poh Chairman, A*STAR Deputy Chairman Prof Tan Chorh Chuan Deputy Chairman, A*STAR President, National University of Singapore Members Prof Low Teck Seng Managing Director, A*STAR Prof Sir George Radda Chairman, Biomedical Research Council, A*STAR Emeritus Professor of Molecular Cardiology, University of Oxford Prof Charles Zukoski Chairman, Science and Engineering Research Council, A*STAR Prof Bertil Andersson President-Designate & Provost, Nanyang Technological University Dr Beh Swan Gin Managing Director, Economic Development Board Mr Bruce Brown Chief Technology Officer, The Proctor & Gamble Company Dr William W. Chin Executive Dean for Research Professor of Medicine, Harvard Medical School Prof Sir Alex Markham Professor of Medicine, University of Leeds Mr Ng Cher Pong Deputy Secretary (Policy), Ministry of Education Mr Ng Wai Choong Deputy Secretary (Policy), Ministry of Finance Mr Ong Boon Hwee Chief Operating Officer, Singapore Power Ltd Prof Sir John O’ Reilly Vice Chancellor, Cranfield University Lord Ronald Oxburgh Deputy Chairman, Science and Engineering Research Council, A*STAR House of Lords Select Committee on Science and Technology, UK 5 Mr Quek Tong Boon Chief Defence Scientist/Chief Research & Technology Officer, Ministry of Defence Dr Sun Shih-Wei Chief Executive Officer, United Microelectronics Corporation Prof Tan Eng Chye Deputy President (Academic Affairs) and Provost, National University of Singapore Mr Tan Kok Kiong Andrew Chief Executive Officer, National Environment Agency Centre Fellow, Centre for Liveable Cities, Ministry of National Development Dr Patrick Vallance Senior Vice President, Medicines Discovery & Development, GlaxoSmithKline Dr Tadataka Yamada Scientific Advisor to CEO and Member of Board of Directors, Takeda Pharmaceutical Corporation Operating Partner at Frazier Healthcare 6 KEY MANAGEMENT PERSONNEL Chairman Mr Lim Chuan Poh Deputy Chairman Prof Tan Chorh Chuan Managing Director Prof Low Teck Seng Scientific Advisor to A*STAR Chairman Dr Sydney Brenner Chairman, Biomedical Research Council (BMRC) Prof Sir George Radda Chairman, Science and Engineering Research Council (SERC) Prof Charles Zukoski Chief Scientist Prof Sir David Lane Deputy Managing Director (Corporate Planning and Administration) Mr Teoh Yong Sea Deputy Chairman, Translational and Clinical Sciences Group, BMRC Prof Edward Holmes Executive Director, BMRC Prof Lee Eng Hin Executive Director, SERC Dr Raj Thampuran Executive Director, A*STAR Graduate Academy Dr Lim Khiang Wee Chief Executive, Exploit Technologies Pte Ltd (ETPL) Mr Philip Lim General-Counsel Mr Suresh Sachi 7 8 MAJOR SHAREHOLDER OF SUBSIDIARY COMPANIES Name of subsidiary company: Exploit Technologies Pte Ltd % shareholdings in company: 100% Exploit Technologies Pte Ltd (ETPL) Exploit Technologies is the strategic marketing and commercialisation arm of the Agency for Science, Technology and Research (A*STAR). Its mission is to support A*STAR in transforming the economy through commercialising R&D. Exploit Technologies enhances the research output of A*STAR scientists by translating their inventions into marketable products or processes. Through licensing deals and spin-offs with industry partners, Exploit Technologies is a key driver of technology transfer in Singapore. It actively engages industry leaders and players to commercialise A*STAR's technologies and capabilities, bridging the gap from mind to market. Exploit Technologies‘ charter is to identify, protect and exploit promising intellectual property (IP) created by A*STAR‘s research institutes. In 2008, Exploit Technologies co-founded the Technology Transfer Network (TTN), a collaborative alliance of technology transfer offices, to help start-ups to manage and commercialise their intellectual property. In addition, Exploit Technologies also launched the Angel Investment Management (AIM) initiative to help start-ups to gain wider access to Angel investors in Singapore and the region. 9 LIST OF A*STAR RESEARCH INSTITUTES, CONSORTIA & CENTRES A*STAR has 14 research institutes and 6 research consortia and centres, spanning a broad range of research areas from the biomedical sciences, to the physical sciences and engineering. Biomedical Research Institutes, Consortia & Centres Bioinformatics Institute (BII) Bioprocessing Technology Institute (BTI) Experimental Therapeutics Centre (ETC) Genome Institute of Singapore (GIS) Institute of Bioengineering and Nanotechnology (IBN) Institute of Medical Biology (IMB) Institute of Molecular and Cell Biology (IMCB) A*STAR - Duke-NUS Graduate Medical School Neuroscience Research Partnership (NRP) Singapore Bioimaging Consortium (SBIC) Singapore Institute for Clinical Sciences (SICS) Singapore Immunology Network (SIgN) Singapore Stem Cell Consortium (SSCC) Science and Engineering Research Institutes & Centre Data Storage Institute (DSI) Institute of Chemical and Engineering Sciences (ICES) Institute of High Performance Computing (IHPC) Institute for Infocomm Research (I2R) Institute of Materials Research and Engineering (IMRE) Institute of Microelectronics (IME) National Metrology Centre (NMC) Singapore Institute of Manufacturing Technology (SIMTech) STAFF STRENGTH IN A*STAR A*STAR headquarters has a staff strength of 217. The total strength of the larger A*STAR community, including scientists and researchers, technical and non-technical staff, and industry development and commercialisation staff, was 4078 as at the end of FY2010. 10 HIGHLIGHTS OF KEY ACCOMPLISHMENTS A*STAR had a fruitful and productive year in FY2010. It made good progress in achieving its Key Performance Indicators under the 2010 Science and Technology Plan. All six KPI targets were met. Category Key Performance Indicator Human Capital No. of PhD Students trained 220 and graduated 555 252.3 No. of RI staff spun out to 835 locally-based industry as RSEs 1058 126.7 No. of primary applications filed 1170 106.4 No. papers published (in SCI 7940 and EI journals) 15,978 201.2 No. of industry projects 1,120 1,554 138.8 Industry funding ($mil) 197 219.53 111.4 Intellectual Capital Industrial Capital Target Actual (by end (FY2006 FY2010) to FY2010) patent 1,100 % Achievement INTERNATIONAL AND LOCAL AWARDS WON BY A*STAR SCIENTISTS AND ENTITIES A*STAR‘s scientists won several international and local awards in FY2010. They include: The I²R Brain-Computer Interface (BCI) team led by Dr Guan Cuntai working jointly with medical doctors from Tan Tock Seng Hospital (Dr Karen Chua Sui Geok, Mr Christopher Kuah) and National Neuroscience Institute (Associate Professor Ang Beng Ti) won the Annual BCI Research Award for their project ―Motor imagerybased Brain-Computer Interface robotic rehabilitation for stroke‖. Professor David Townsend, Head of PET and SPECT Development for SBIC and Director of the Clinical Imaging Research Centre, was honoured with the prestigious 2010 IEEEMedal for Innovations in Healthcare Technology for the design, commercial development and clinical implementation of the PET/CT scanner. Professor Lam Kong Peng, Scientific Director of BTI, was conferred the Arthur Kornberg Memorial Award by the Asia Pacific International Molecular Biology Network (A-IMBN). Dr Melissa Fullwood, an A*STAR scholar, was the first Singaporean to win one of four Regional General Electric (GE) & Science Prizes for Young Life Scientists for her original essay, ―Genome-Wide Chromatin Loops Regulate Transcription‖. Professor Boris Lukiyanchuk, Senior Scientist at DSI, was recently elected a Fellow of Optical Society of America (OSA) and recognised for his outstanding contributions in theory of laser-matter interactions, including laser thermochemistry, laser cleaning, laser ablation and plasmonics. 11 A team of researchers from I²R was awarded at the 2010 World Technology Awards for their innovative Dance!3D system. The team comprised of Dr Susanto Rahardja, Dr Farzam Farbiz, Dr Huang Zhiyong, Mr Chua Gim Guan, Dr Yuan Miaolong, Ms Christina Tang Ka Yin, Ms Loke Mei Hwan, Dr Corey Manders, Dr Ishtiaq Rasool Khan, Dr Zhu Yongwei, and Mr Chan Ti Eu. Dr Tan Yen Nee, a Research Engineer with IMRE, was one of the winners of the 2010 AsiaNANO Young Researcher Award. Dr Low Hong Yee from IMRE was one of the three recipients of the prestigious L'Oreal Singapore For Women in Science National Fellowships. Dr Patrick Lo Guo-Qiang, Dr Liow Tsung-Yang, Dr Ang Kah Wee and Dr Yu Mingbin from IME received the President’s Technology Award (PTA) in recognition of their outstanding contributions in advancing Singapore‘s semiconductor technology and industry development through cutting edge research on silicon photonics. Professor Yoshiaki Ito from IMCB received the President’s Science Award (PSA) for his breakthrough discovery of the tumor suppressor roles of RUNX3 in gastric and colon cancers. Professor Andy Hor, Executive Director of IMRE, was awarded the Outstanding Chemist Award (OCA) 2010 by the Department of Chemistry, National University of Singapore (NUS). Asst Prof Wu Jishan, who shares a joint appointment with NUS' Department of Chemistry and IMRE, was one of the winners of the 2010 Young Scientist Award. Dr. Susanto Rahardja and Dr Liang Ying Chang of I2R were recognized for their efforts in research and conferred the status of ‗IEEE Fellow’ by the Institute of Electrical and Electronics Engineers (IEEE), the highest honor to be bestowed by IEEE. A*STAR scientists and research institutes which had turned in the best performance on each of the dimensions of the 3Cs – Human Capital, Intellectual Capital, and Industrial Capital, were honoured with the A*STAR Awards 2010. They include: Dr Chandrashekar Verma, Division Head and Senior Principal Investigator at BII, and Dr Akkipeddi Ramam, Senior Scientist at IMRE, clinched the Star Employee award that recognises staff who best embody A*STAR's values of Action, Speed, Teamwork, Agility, Resolve and Integrity. Dr Nikolai Yakovlev, Research Scientist at IMRE and A/Professor Graeme R Guy, Senior Principal Investigator at IMCB, were conferred the Most Inspiring Mentor Award that recognises inspirational and dedicated scientists who have played fundamental roles in nurturing other scientists and scholars. NanoImprint Lithography Lab at IMRE won the 2011 TALENT (The Award for Leading, Educating & Nurturing Talent) for providing a conducive environment for nurturing young researchers. SIMTech won the Most Valuable Partner Award as the research institute which contributed the most to an industry partner through their collaboration. SIMTech also won the Most Income Derived from Alternative Sources Award for being the most successful in attracting external funding. GIS and IME were conferred The Outstanding Publications Award, which recognises a research institute from each of the Biomedical and Science and Engineering Research Councils for the highest number of quality publications in high impact journals. IME was awarded the Patent Power Award for having the highest number of primary patents filed per budget dollar spent. 12 The Sustainable Manufacturing Centre (SMC) at SIMTech won the A*STAR Borderless Award for its excellent collaborative work across organisational boundaries. The 2011 Star Innovation Award was awarded to the Opensource Computing team, Technology Innovation and Scientific Computing at BII as well as to Wong Jwee Huat, Senior FM Specialist at ICES, for ideas that have resulted in substantial cost savings for A*STAR. Dr Kostas G Anagostakis, Founder of Niometrics Pte Ltd, won the ScientistEntrepreneur Award for having successfully commercialised and spun-off his research from A*STAR research institutes to the industry. A*STAR has also achieved high standards of business, operational and organisational excellence which was recognised through the many awards it won in FY2010. Public Service Milestone Award - this celebrates outstanding achievements of public agencies that have attained best-in-class standards and innovative practices. Leading HR Practices in Manpower Resourcing & Planning Award (The Singapore HR Awards 2010) - for achieving all-round excellence in staffing, manpower planning, deployment, recruitment and selection strategies and programmes. Leading CEO Award (The Singapore HR Awards 2010) - Ms Yena Lim, MD A*STAR, clinched the Leading CEO Award for her dedication, championship of innovative and effective HR ideas and practices, and strong commitment and support towards the work of HR in A*STAR. Singapore H.E.A.L.T.H (Helping Employees Achieve Life-Time Health) Award – Silver - presented by the Health Promotion Board to give national recognition to organisations with commendable Workplace Health Promotion (WHP) programmes. ISO 9001:2008 (re-certified from 2010-2013) - A*STAR has ISO certification for its key business processes to ensure consistent high quality performance. Major Employer of Nanyang Technological University (NTU) – As one of the six major employers of NTU students, A*STAR was honoured by the University at the opening of NTU‘s Career Fair. Winner of Best Graduate Development Practices at the HRM Awards 2011 recognises organisations with effective graduate recruitment and training practices that are aligned to the organisation's goals and future talent needs. MTI Borderless Award - celebrates the Best of MTI innovations through collaboration beyond boundaries. A*STAR‘s reputation as an ―Employer of Choice‖ was affirmed in the JobsFactory Employer of Choice Survey 2010 that ranked A*STAR #6 as an Employer of Choice out of over 50 public sector organisations. A*STAR also secured a place in Singapore‘s top 100 Leading Graduate Employers, a result of votes cast by Singaporean undergraduate students and fresh grads. 13 HIGHLIGHTS OF THE YEAR IN REVIEW Apr 2010 Four Centres of Innovation (COIs) in local polytechnics came onboard the A*STAR‘s Growing Enterprises with Technology Upgrade (GET-Up) programme to help more small and medium enterprises (SMEs) upgrade their R&D capabilities to stay competitive in this economy. The Institute of Microelectronics (IME) announced the launch of the MicroElectro-Mechanical-Systems (MEMS) Consortium, bringing together eight MNCs and local enterprises from the MEMS supply chain to collaborate on research so as to grow the MEMS industry in Singapore. Twelve research projects on infectious diseases and immunology were awarded grants by A*STAR‘s Biomedical Research Council (BMRC) and Singapore Immunology Network (SIgN). These projects accounted for over one-third of the $23 million in grants from BMRC‘s 8th General Grant Call and SIgN‘s 4th Grant Call. A record number of 469 research projects were submitted for the Singapore Science and Engineering Fair (SSEF) and the A*STAR Talent Search (ATS). Three outstanding student scientists were selected by the judging panel headed by Nobel Laureate, Professor Barry Marshall, to receive the A*STAR Talent Search Award. A*STAR hosted visits by: Dr Ernesto Zedillo, Director of Proctor & Gamble Co. (P&G) and former President of Mexico Professor David Leebron, President of Rice University May 2010 Imperial College London bestowed its highest honour on A*STAR Chairman Lim Chuan Poh by appointing him a Fellow of the College, an award for persons of outstanding distinction. The Singapore Environment Council (SEC) and the Singapore Institute of Manufacturing Technology (SIMTech) inked an agreement to launch Singapore and South East Asia‘s first carbon label. This Carbon Label is a Singapore initiative that will support the country‘s transition to a recognised low carbon economy. Fujitsu and A*STAR jointly announced the official opening of Fujitsu‘s first bio-medical focused research facility in the South East Asia region. Fujitsu Laboratories Singapore would support a number of key research initiatives, working in collaboration with A*STAR‘s Experimental Therapeutics Centre (ETC), National University of Singapore (NUS), National University Hospital (NUH) and the Cancer Science Institute (CSI) to drive research for diagnosis of cancer and diseases. A*STAR hosted separate visits by: Mr Rainer Bruderle, the Minister of Economics and Technology of Germany Honorable Senor Josep Huguet i Biosca, Catalonia (Spain), the Minister of Innovation, Universities and Enterprises of Spain Mr Masaharu Nakagawa, Senior Vice Minister of Education, Culture, 14 Sports, Science and Technology (MEXT) of Japan Jun 2010 ImaginAb, Inc. and A*STAR embarked on a collaborative project to reengineer a therapeutic antibody asset against a promising oncology target – PRL3 – into an imaging agent as a first step towards better understanding the biology of this target in humans. Led by Prof Sir David Lane, A*STAR‘s Chief Scientist, the collaboration tapped on the cutting edge imaging technologies at the Singapore Bioimaging Consortium (SBIC) under A*STAR. A*STAR showcased more than 10 innovative market-ready technologies at CommunicAsia 2010. Among the technologies making their debut at the mega ICT event were a group of personal 3D entertainment technologies developed by researchers from the Institute for Infocomm Research (I²R). The I²R Brain-Computer Interface (BCI) team, led by Dr Guan Cuntai working in collaboration with medical doctors from Tan Tock Seng Hospital and National Neuroscience Institute, won the Annual BCI Research Award for their project ―Motor imagery-based Brain-Computer Interface robotic rehabilitation for stroke‖. The team beat sixty other international entries to secure the award. Professor David Townsend, Head of PET and SPECT Development for the Singapore Bioimaging Consortium (SBIC) and Director of the Clinical Imaging Research Centre, was honoured with the prestigious 2010 IEEEMedal for Innovations in Healthcare Technology for the design, commercial development and clinical implementation of the PET/CT scanner, an innovation that have made diagnostic imaging of cancer faster and more accurate for millions of patients. Prof Townsend received the medal jointly with his co-inventor, engineer Ronald Nutt, at the IEEE Honors Ceremony in Montreal, Quebec, Canada. A*STAR introduced OLIVIA and LUCAS, the first social robots to be unveiled in Singapore, at Robocup2010. Developed under A*STAR‘s Social Robotics Programme (ASoRo), the robots were results of the integration of research capabilities of the Institute for Infocomm Research (I²R), the Data Storage Institute (DSI) and the Singapore Institute of Manufacturing Technology (SIMTech). A*STAR hosted visits by: Her Excellency Prof Dr Annette Schavan, German Federal Minister of Education and Research (BMBF) Mr Martin Plachy, the First Deputy Minister of Regional Development and Singapore Honorary Counsul General in the Czech Republic Dr Tamotsu Nomakuchi, President of the National Institute of Advanced Industrial Science and Technology (AIST), Japan July 2010 At A*STAR‘s Scholarship Awards Ceremony, A*STAR announced that its 10-year scholarship drive had been successful in nurturing a pipeline of 1,000 scholars who would contribute to the Singapore R&D scene. Switzerland‘s Cytos Biotechnology and A*STAR jointly announced their first collaboration on a virus-like particle (VLP) vaccine. This partnership, which involved academic and clinical partners across Singapore, aimed to conduct 15 research, develop and commercialise a VLP vaccine to manage influenza infections. Four companies, namely, Rolls Royce, Vestas, SP PowerGrid and CEI Contract Manufacturing, entered into strategic partnerships with A*STAR to develop smart grid and distributed energy solutions. This was announced at the groundbreaking ceremony of the Experimental Power Grid Centre (EPGC), the smart grid research facility on Jurong Island by Guest-ofHonour, Mr Ravi Menon, Permanent Secretary, Ministry of Trade & Industry. The Institute of Microelectronics (IME) announced a collaborative partnership with Stanford University to develop silicon nanowire based circuits that were inspired by the brain. This artificial system, organised like the biological nervous system, promised to drive the future of humanoid robots and pave the way for a generation of supercomputers that could perform highly complex decision-making for gaming and defense technologies. A*STAR hosted separate visits by the following: Her Excellency Doris Leuthard, President of the Swiss Confederation Delegation led by Mr Michitaka Nakatomi, President of the Japan External Trade Organization (JETRO) Three-member Chinese delegation led by Mr Xu Chaoqian, Deputy Director-General, Chinese Ministry of Science and Technology (MOST) Mr Yan Li, Mayor of Suzhou, China Aug 2010 Small and Medium-sized Enterprises (SMEs) received a shot in the arm with the launch of the new SME Manufacturing Excellence (S.M.E) Programme developed by the Singapore Institute of Manufacturing Technology (SIMTech). The S$2 million programme aimed to help SMEs in the manufacturing sector raise their productivity through process innovation. The Institute of Materials Research and Engineering (IMRE) and the Institute of High Performance Computing (IHPC), together with Economic Development Board, International Enterprise Singapore and SPRING, launched the Industrial Consortium On Nanoimprint (ICON) to help enterprises reap the rewards that nanoimprint technology (NIT) offered. ICON would enable industry partners to gain first-hand access to the advanced nanoimprint developments in A*STAR and work jointly with A*STAR on projects to develop new products and applications. Organised with the support of the Singapore National Commission for UNESCO and in partnership with A*STAR, the L‘Oréal Singapore For Women in Science National Fellowships 2010 honoured three exceptional women in science for their contribution to material sciences. Dr Low Hong Yee, a Senior Scientist from the Institute of Materials Research and Engineering (IMRE), was one of the three recipients. A*STAR hosted separate visits by the following: Mr Ji Jianye, Mayor of Nanjing, China Mr Zhao Xiaojiang, Vice Mayor, Nanjing, China Colonel (Rtd) Pengiran Dato Paduka Azmansham bin Pengiran Mohamad, Deputy Permanent Secretary for Defence, Brunei Delegation of Members of Parliament (Japan) led by Mr Takeaki 16 Sept 2010 Matsumoto, Lower House Chairman of the Standing Committee on Rule and Administration Professor Yang Wei, President of Zhejiang University, China Professor Thomas Magnanti, President of Singapore University of Technology and Design Nine innovative technologies from A*STAR‘s research institutes with the potential to bolster Singapore‘s green buildings and construction industry were on display at BEX Asia 2010. This included A*STAR‘s eco-friendly halogen and toxic gas-free flame retardant and fire-proof additive that prevented the spread of fire by forming a blanket of solid material at low temperatures. Molecular Diagnostic (MDx) licenses developed by A*STAR research institutes such as Dengue/Chikungunya Multiplex Detection Kits and Mycobacterium Tuberculosis Detection Kit were acquired by AITBIOTECH Pte Ltd, a Singapore-based company. Prime Minister Lee Hsien Loong announced the Government‘s plan to allocate S$16.1 billion for research, innovation and enterprise activities for the period of 2011-2015. This was a 20 per cent increase over the S$13.55 billion committed in the previous tranche. The increased outlay is an indication of the Government‘s continued commitment to R&D as a long-term strategy to transform Singapore into an innovation-driven and knowledgebased economy. In the same month, Mr Lim Hng Kiang, Minister for Trade and Industry, also announced that S$1.35 billion of the budget would be allocated under the Industry Alignment Fund to fund projects, bringing together public sector R&D performers with industry players to work on projects with industry relevance. This was aimed at promoting closer collaboration with industry in order to accelerate economic outcomes from Singapore‘s R&D activities. Procter & Gamble (P&G) and A*STAR signed a three-year Master Research Collaboration Agreement (MRCA) to jumpstart P&G‘s innovation expansion in Singapore and strengthen P&G‘s R&D presence in Singapore. This agreement came ahead of the opening of P&G‘s new Innovation Center, which was expected to be completed by late 2013. Professor Chong Tow Chong, the Provost of Singapore University of Technology and Design and former Executive Director of A*STAR‘s Science and Engineering Council, was the recipient of the 2010 President's Science and Technology Medal (PSTM) at the 2010 President‘s Science and Technology Awards (PSTA) Ceremony. The 2010 President‘s Science Award (PSA) was presented to Professor Yoshiaki Ito from the Cancer Science Institute (CSI) and A*STAR‘s Institute of Molecular and Cell Biology (IMCB), and Professor Wong Tien Yin from the Singapore Eye Research Institute (SERI), Singapore National Eye Centre (SNEC) and National University Health System (NUHS). The 2010 President‘s Technology Award was conferred onto a team of research engineers from A*STAR‘s Institute of Microelectronics (IME) for their work in silicon photonics. A*STAR hosted a visit by Mr John Whitehead, Chief Executive and Secretary to the New Zealand Treasury, and his delegation. 17 Oct 2010 Professor Low Teck Seng and Dr Raj Thampuran took up appointments as the Managing Director of A*STAR and Executive Director of the Science and Engineering Research Council (SERC) respectively. The Institute for Infocomm Research (I²R) signed a Memorandum of Understanding with leading global and local industry partners and small and medium enterprises to jointly explore and collaborate on a research consortium on Interactive TV technologies. The industry partners included Sumitomo Electric Networks, Nippon Telegraph and Telephone Corporation, and Network For Electronic Transfers (Singapore) Pte Ltd. The Biomedical Sciences (BMS) Executive Committee announced at the 15th Biomedical Sciences International Advisory Council (BMS IAC) meeting that the Government would be investing S$3.7 billion in Biomedical Sciences research for the period 2011 – 2015. This 12% increase over the investment by the Government for the period 2006 – 2010 was a strong signal that BMS R&D remained a priority in Singapore‘s long-term strategy to boost its economic competitiveness, achieve sustained growth and establish the country as Asia‘s Innovation Capital. The Singapore Institute of Manufacturing Technology (SIMTech) launched the Nanotechnology in Manufacturing Initiative (NiMI) to explore nanomaterials for industry applications and address challenges in the adoption of nanotechnology for manufacturing. Thirteen multinational corporations and small and medium enterprises in the areas of coating, instrumentation, materials, clean energy, testing, inspection and certification participated in the initiative to exploit new market opportunities in the global nanotechnology market, which would be worth more than US$2.4 trillion in 2015. A*STAR hosted visits by: Mr Conor Lenihan, Minister of State for Science, Technology, Innovation and Natural Resources, Ireland Madam Professor Ma Dexiu, Party Secretary and Chairperson of the University Council of Shanghai Jiao Tong University in China 18-member delegation of Higher Education Leaders from Estonia Nov 2010 Professor David Townsend, Professor Dim-Lee Kwong and Dr Tony Quek were honoured at the opening of the Institute of Electrical and Electronics Engineers (IEEE) at Solaris@Fusionopolis. Professor David Townsend was honoured for being bestowed the prestigious 2010 IEEE Medal for Innovations in Healthcare Technology, Professor Dim-Lee Kwong for winning the 2011 IEEE Frederik Philips Award which would be presented to him in December 2011, and Dr Tony Quek for winning two Best Paper Awards in 2010. Nanyang Technological University (NTU) and A*STAR jointly launched a new PhD programme focusing on human immunology and immune regulation. Under this novel partnership, NTU‘s School of Biological Sciences and the Singapore Immunology Network (SIgN) would offer a comprehensive, world-class PhD training programme to local and international aspiring scientists. A team from the Institute for Infocomm Research (I2R) took top honours for 18 the Known-item-Search (KIS) task at National Institute and Standards Technology TRECVID Conference 2010, beating 49 participating global teams and emerging best among teams such as National University of Singapore (NUS), Carnegie Mellon University, City University of Hong Kong and Dublin City University. Professor Lam Kong Peng, Scientific Director of the Bioprocessing Technology Institute (BTI), became the first Singaporean to be honoured with the Arthur Kornberg Memorial Award by the Asia Pacific International Molecular Biology Network (A-IMBN) based in Seoul, Korea. The award by one of Asia's key organisations for research in molecular biology and biotechnology is given to promising scientists who have demonstrated excellence in research relevant to the needs of humanity. The Institute of Materials Research and Engineering (IMRE) and 10 European Union (EU) research organisations entered into a collaboration to build a single molecule processor chip. The groundbreaking project, dubbed Atomic Scale and Single Molecule Logic Gate Technologies (ATMOL), would establish a new process for making a complete molecular chip that would help to increase computing power significantly while taking up only a small fraction of the space required by today‘s standards. The Institute of Microelectronics (IME) announced a collaborative partnership with Stanford University to develop nanoelectromechanical (NEM) relay technology to enable ultra-low power computation. NEMS-based integrated circuits are ideal for a wide range of emerging green electronics solutions as they eliminate leakage power, one of the leading sources of power consumption in today‘s scaled devices. A*STAR hosted a visit by a Chinese delegation led by His Excellency Xi Jinping, Vice President of the People‘s Republic of China. Dec 2010 The Singapore Bioimaging Consortium (SBIC), National University of Singapore, National University Health System (NUHS) and SingHealth embarked on five separate collaborative research projects with Bayer HealthCare Singapore, a subsidiary of Germany-based Bayer AG. The investments from Bayer amounted to S$14.5 million and were aimed at improving early diagnosis and treatment outcomes of cancer patients. The Institute of Microelectronics (IME) and local start-up Ney-Li Pte Ltd entered into a collaboration to develop breakthrough technologies for green devices. The collaboration leverages IME‘s integrated circuit design expertise and Ney-Li‘s market and application knowledge in power conversion. The Singapore-Stanford Biodesign (SSB) Program Office awarded two doctors and two engineers the inaugural Singapore-Stanford Biodesign (SSB) Fellowships, which would equip them with innovation and entrepreneurship skills to tackle today‘s healthcare issues. The Institute of Microelectronics (IME) and the University of Illinois at Urbana-Champaign entered into a research collaboration to discover a way for improved nanosensor stability and device reproducibility, and to take the technology a decisive step closer to commercialisation. 19 A*STAR‘s 2009 National Survey of R&D revealed that Singapore‘s public expenditure on R&D (PUBERD) was an unprecedented S$2.3 billion or 0.87% of GDP in 2009. This was a 15.4% increase in PUBERD from S$2 billion in 2008, despite the 3.1% shrinkage in Singapore‘s GDP from 2008 to 2009. The compound annual growth rate (CAGR) of PUBERD from 2000 to 2009 was 8.2% — an indication of the Government‘s strong commitment to R&D. A*STAR and Switzerland‘s Cytos Biotechnology Ltd jointly announced the extension of their existing collaboration for the development of a virus-like particle (VLP) based Influenza vaccine. Under this revised agreement, A*STAR would engage Cytos to develop, manufacture and supply A*STAR with a Good Manufacturing Practice (GMP)-grade investigational vaccine candidate for a human proof-of-concept study in Singapore. The Institute of Microelectronics (IME) and University of Washington‘s (UW) Department of Electrical Engineering announced that they would be jointly developing a parallel assembly technique to accurately and efficiently assemble ultrathin chips. This project would be funded by the Defense Advanced Research Projects Agency (DARPA), an agency of the United States Department of Defense. A*STAR hosted a visit led by His Excellency Banri Kaieda, Minister of State for Science and Technology Policy in Japan. Jan 2011 The Institute for Infocomm Research (I²R) and Exploit Technologies (ETPL) signed a R&D agreement with Huawei to jointly develop new areas of infocomm technologies in Singapore that would have strategic, tactical or commercial potential for global markets and the infocomm industry in Singapore in the near future. A team of researchers from the Institute for Infocomm Research (I2R), creators of the highly successful Dance!3D system, was awarded at the World Technology Summit and Awards 2010 in New York. Local SME, KAI Square Pte Ltd (KAI Square), signed a licensing agreement with Exploit Technologies (ETPL) to commercialise a ―black box‖ platform for automobiles, a move that would help it enter the US$3 billion global DVR market. A*STAR hosted a visit by Professor Duong Ngoc Hai, Vice-President of Vietnam Academy of Science and Technology. Feb 2011 The Institute for Infocomm Research (I²R) entered into the second phase of an R&D agreement with Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier (UJF) and the National University of Singapore (NUS) for their joint laboratory in Singapore known as the Image, Pervasive Access Lab (IPAL). This new phase saw two additional members Université Pierre et Marie Curie and Institut Telecom into the agreement. The Singapore Immunology Network (SIgN) and VIVALIS, a French biopharmaceutical company, announced the discovery of two new fully human monoclonal antibodies which could battle Chikungunya, a disease that had no available vaccine or specific treatment. The international team of scientists, coordinated by Dr Lucile Warter of SIgN, published their 20 groundbreaking discovery in the Journal of Immunology. Western Digital entered into an agreement with the Data Storage Institute (DSI) to collaborate on the development of advanced head, media and hard drive system design. A*STAR hosted separate visits by the following: His Excellency Dr Heinz Fischer, Federal President of the Republic of Austria The Honourable Mr Glen Murray, Minister of Research and Innovation, Ontario, Canada Mr Martin Donnelly, Permanent Secretary of UK Department for Business, Innovation and Skills (BIS) His Excellency Mr Meng Jianzhu, State Councillor of the People‘s Republic of China Five-member delegation from the New Zealand Defence Technology Agency Eight-member delegation from the National Science Technology and Innovation Policy Office in Thailand Mar 2011 More than 30 international experts on biofuels converged on Singapore for the Keystone Symposium on Biofuels conference, jointly organized by A*STAR and Keystone Symposia on Molecular and Cellular Biology. The Italian FIRC Institute of Molecular Oncology (IFOM) and A*STAR launched the IFOM-p53Lab Joint Research Laboratory for cancer research in Singapore. The IFOM-p53Lab Joint Research Laboratory would focus on new targeted therapies and would leverage the combined knowledge and technological expertise of the two agencies to accelerate the transfer of scientific findings from the laboratory to clinical practice. The Institute of Microelectronics (IME) and ELTA Systems Ltd. (ELTA), a electronic defence systems company wholly owned subsidiary of Israel Aerospace Industries (IAI), inked an agreement to design and develop a novel through-silicon via (TSV) substrate technology for multi-chip module packaging. The aim was to develop new applications in multi-chip modules in radar, communication, and electronic warfare systems. 21 HIGHLIGHTS OF SCIENTIFIC BREAKTHROUGHS IN A*STAR RESEARCH INSTITUTES, CONSORTIA & CENTRES Below are some examples of discoveries and innovations made by teams of scientists from research entities under A*STAR’s Biomedical Research and Science and Engineering Research Councils. Biomedical Sciences Scientists led by GIS and Sun Yat-Sen University Cancer Centre identified genes associated with the development of a form of throat cancer Scientists from Singapore, China and the USA led by Dr Liu Jianjun, from the Genome Institute of Singapore (GIS), and Professor Yi-Xin Zeng, President of the Sun Yat-Sen University Cancer Centre, identified three new susceptibility genes in a genome-wide association study of nasopharyngeal carcinoma (NPC), a form of throat cancer, which involved more than 10,000 subjects. Published in Nature Genetics, the findings advanced the understanding of the important role played by host genetic variation in influencing the susceptibility to NPC. IMB scientists uncovered the trail behind growing too old, too soon Institute of Medical Biology (IMB) scientists, led by Professor Alan Colman and Professor Colin Stewart, collaborated with the University of Hong Kong‘s Department of Medicine to produce the world's first human cell model of progeria. Progeria is a disease resulting in severe premature ageing in one in four to eight million children worldwide. This human progeria model allows the group to trace and analyse the distinctive characteristics of progeria as it progresses in human cells. Previously, only mouse models of the disease were available. Their findings were published in the prestigious scientific journal, Cell Stem Cell. IMCB scientists discovered how PRL-3, a protein, played a key role in tumorigenesis and cancer metastasis A team of scientists led by Dr Zeng Qi from the Institute for Molecular and Cell Biology (IMCB) made a discovery about how PRL-3, a protein that played a key role in tumorigenesis and cancer metastasis, was regulated in the body by PCBP1. Dr Zeng, together with her collaborator, Dr Leah Vardy from Institute of IMB (IMB), also found that PCBP1 impeded the translation of PRL-3 mRNA. Their discovery, published in the leading journal Cancer Cell, shed light on the role of PRL-3 in cancer and suggested possible ways to prevent metastasis, arguably the most pernicious and harmful aspect of the disease. Researchers revealed genetic link to infectious disease susceptibility through largescale study Researchers from A*STAR, the Wellcome Trust Centre for Human Genetics and National University Health System (NUHS) identified new genetic variants that could increase the susceptibility to several infectious diseases, including tuberculosis and malaria. With a greater understanding of the role of the gene implicated, findings could one day lead to better therapies and vaccines. SIgN and Novartis Discover Breakthrough Drug Against Malaria Scientists from the Singapore Immunology Network (SIgN) led by Dr Laurent Renia made a breakthrough concerning a drug that was effective against malaria. Their work, carried out 22 with industry leader Novartis, the Swiss Tropical and Public Health Institute, and The Scripps Research Institute, was published in top scientific journal, Science. The discovery and validation of the new drug, spiroindolone NITD609, was timely in the face of emerging strains of drug-resistant malaria. Physical Sciences and Engineering DSI Researcher among pioneer investigator of Fano Resonance in Plasmonic Nanostructures and Metamaterials Professor Boris Lukiyanchuk, from the Data Storage Institute (DSI), was among the pioneers investigating Fano resonance in plasmonic materials and metamaterials. Results of his investigations, together with complimentary studies of distinguished groups from Rice University, Houston, USA, Imperial College London and University of Southampton, UK and also from the University of Stuttgart, Germany were presented in their review paper in Nature Materials. I2R Known-item-Search (KIS) technology took top honours at US standards annual TRECVID conference A team from the Institute for Infocomms Research (I2R) managed to obtain the top scores beating 49 participating global teams and emerging first in the Known-item-Search (KIS) task at National Institute and Standards Technology TRECVID Conference 2010, revealing its capabilities in content-based analysis of and retrieval from digital video via open, metricsbased evaluation. The final 15 teams included teams from the National University of Singapore (NUS), Carnegie Mellon University, City University of Hong Kong and Dublin City University. Researchers from IME behind new bedside tool for faster treatment of heart patients The researchers from A*STAR Institute of Microelectronics (IME) developed a novel microfluidic system for rapid and sensitive detection of rare circulating endothelial progenitor cells (EPC). The microfluidic system could be used as a bedside tool for point-of-care diagnostics to assist clinicians to perform in-depth studies to uncover new potential health implications of EPC levels, to monitor the efficiency of drug therapy or to help cardiologists prescribe suitable treatments for heart patients with clogged arteries. IMRE uncovered a new and revolutionary approach to preparing hydrogels for engineering and biomedical applications A team from the Institute of Materials Research and Engineering (IMRE) developed a new and revolutionary approach for preparing hydrogels, a network of polymer chains that were biocompatible, biodegradable and easily moulded into various shapes and sizes. The main advantage of this novel approach lay in its ―living‖ property that could create a controlled in situ gelling system to produce tailor-made hydrogels with the desired structures and properties for a new range of biomedical applications. Their work was published in the Journal of the American Chemical Society, one of the leading journals in Chemistry. Scientists from SIMTech discovered new laser technology process with high potential for making security watermarks A team of scientists at the Singapore Institute of Manufacturing Technology (SIMTech) discovered a new process for direct patterning in sub-surface of stainless steel using Nd:YAG laser pulses that could be used to enhance the security in the automotive, 23 aerospace and military sectors. The laser markings which would be completely invisible, would have a high potential to be applied in the prevention of counterfeiting by making security watermarks in high value components. The scientists‘ work received endorsement by Frost & Sullivan as one of the emerging laser technologies. 24 HIGHLIGHTS OF SPIN-OFF COMPANIES AND COMMERCIALISATION OF A*STAR TECHNOLOGIES Below are some examples of spin-off companies from A*STAR’s research entities that are delivering innovative products built on technologies developed in A*STAR laboratories. AITBiotech acquired Molecular Diagnostic License for Multiple Pathogens Detection and Swine Flu Mutation Surveillance. AITBiotech Pte Ltd of Singapore acquired several Molecular Diagnostic (MDx) licenses from Exploit Technologies (ETPL) that were developed by research institutes under A*STAR. The assays include Dengue/Chikungunya Multiplex Detection Kits and Mycobacterium Tuberculosis Detection Kit. All these detection kits are used with real-time Polymerase Chain Reaction (PCR) detection system manufactured and distributed by major international Life Science companies like Applied Biosytems, BioRad and Strategene. These assays were developed by a Senior Research Scientist Masafumi Inoue and his team from the Experimental Therapeutics Centre (ETC). D-SIMLAB selected as a 2010 Red Herring Global Top 100 Tech Startup D-SIMLAB, a spin-off company from the Singapore Institute of Manufacturing Technology (SIMTech), was selected as a 2010 Red Herring Global Top 100 Tech Startup. The company, founded by Dr Peter Lendermann, Mr Gan Boon Ping and Dr Nirupam Julka in 2006, had been gaining significant traction in the Aerospace industry through D-SIMSPAIR, a software suite for managing component support contracts in a multi-airline, multi-station network. iTwin received the Frost &Sullivan New Product Innovation Award iTwin, a spinoff company from the Institute for Infocomms Research (I2R), received the 2010 Asia Pacific Frost & Sullivan New Product Innovation Award in the Wireless Data Communication Device Market for reinventing the traditional USB drive by providing simple and secure remote file access. The award is presented each year to the company that has demonstrated measured excellence in a new, innovative product or product line within its industry. Niometrics received the Frost & Sullivan Product Innovation Award for Network Traffic Analysis Solutions. Niometrics licensed from Exploit Technologies (ETPL) a next-generation, highly accurate traffic recognition engine, developed by the Institute for Infocomm Research (I 2R). The licensed technology, codenamed as CUB4, is a home-grown, high-performance, softwarebased traffic analysis engine. Niometrics was awarded the 2010 Asia Pacific Frost & Sullivan New Product Innovation Award for Network Traffic Analysis Solutions by leading growth consulting company Frost and Sullivan. 25 HIGHLIGHTS OF PARTNERSHIPS WITH RESEARCH INSTITUTES AND INDUSTRY Below are examples of some new partnerships that A*STAR established with leading local and global establishments and industry players. Partnerships with industry A*STAR - Fujitsu Fujitsu Laboratories Ltd., Fujitsu Asia Pte Ltd. and A*STAR jointly announced the official opening of a new research facility in Singapore, Fujitsu Laboratories & R&D Division of Fujitsu Asia Pte Ltd, to drive research for diagnosis of cancer and diseases. As Fujitsu‘s first bio-medical focused research facility in the South East Asia region, the laboratory is part of a comprehensive ecosystem which partners universities and research institutes with industryrelevant capabilities that will further strengthen Singapore‘s status as Asia‘s research and development (R&D) hub. Fujitsu will be working with A*STAR on the development of aptamer technology for diagnostics application and business development trials A*STAR - Huawei The Institute for Infocomm Research (I²R) and Exploit Technologies (ETPL) entered into a R&D agreement with Huawei to co-develop new areas of infocomm technologies in Singapore. Under the agreement, I²R and ETPL would work with Huawei on a number of technology-focused R&D activities that would have strategic, tactical or commercial potential for global markets and the infocomm industry in Singapore in the near future. MEMS Consortium The Institute of Microelectronics (IME) announced the launch of the Micro-ElectroMechanical-Systems (MEMS) Consortium to bring together eight MNCs and local enterprises from the MEMS supply chain in public-private sector research collaboration to grow the MEMS industry in Singapore. The members include: Coventor, Inc., EPCOS PTE LTD (A Group Company of TDK-EPC Corporation), GLOBALFOUNDRIES, Intellisense Software Corp., NEC SCHOTT Components Corporation, Seiko Instruments Inc., Systems on Silicon Manufacturing Company Pte. Ltd. (SSMC) and Tango Systems, Inc. A*STAR - P&G Procter & Gamble (P&G) and A*STAR entered into a strategic partnership to jumpstart P&G‘s innovation expansion in Singapore and strengthen P&G‘s R&D presence in Singapore. This Master Research Collaboration Agreement (MRCA) signed by the two organisations comes ahead of the opening of P&G‘s new Innovation Center, which is expected to be completed by late 2013. The three-year MRCA would build on the existing cooperation between P&G and A*STAR which began in 2006 and set the stage for more cutting-edge market innovations. A*STAR - Western Digital Western Digital announced the establishment of an R&D centre in Singapore which would leverage the local talent pool and expertise of research organizations, such as the Data Storage Institute (DSI) and universities in the development of advanced hard drive technologies. The company also entered into an agreement with DSI to collaborate on the development of advanced head, media and hard drive system design. 26 Partnerships with leading research institutes and universities A*STAR - CNRS - UJF - NUS The Institute for Infocomm Research (I²R), a research institute of A*STAR, entered into the second phase of a research and development (R&D) agreement with Centre National de la Recherche Scientifique (CNRS), Université Joseph Fourier (UJF) and the National University of Singapore (NUS) for their joint laboratory in Singapore known as the Image, Pervasive Access Lab, or IPAL. This next phase also marks the addition of Université Pierre et Marie Curie and Institut Telecom as new parties to the agreement. A*STAR - Stanford University The Institute of Microelectronics (IME), a research institute of A*STAR, entered into a collaborative partnership with Stanford University to develop silicon nanowire based circuits that are inspired by the brain. The quest to come up with an artificial system organised like the biological nervous system promised to drive the future of humanoid robots and pave the way for a generation of supercomputers that can perform highly complex decision-making for gaming and defense technologies. A*STAR - Stanford University The Institute of Microelectronics (IME), a research institute of A*STAR, announced a collaborative partnership with Stanford University in USA to co-develop nanoelectromechanical (NEM) relay technology to enable ultra-low power computation. NEMS-based integrated circuits are ideal for a wide range of emerging green electronics solutions as they eliminate leakage power, one of the leading sources of power consumption in today‘s scaled devices. A*STAR - NTU Nanyang Technological University (NTU) and A*STAR jointly launched a new PhD programme focusing on human immunology and immune regulation. Under this novel partnership, NTU‘s School of Biological Sciences and A*STAR‘s consortium, Singapore Immunology Network (SIgN), will jointly offer a comprehensive, world-class PhD training programme to local and international aspiring scientists from 2011. A*STAR Institute - University of Illinois at Urbana-Champaign The Institute of Microelectronics (IME), a research institute of A*STAR, and the University of Illinois at Urbana-Champaign (Illinois) entered into a research collaboration focused on identifying and defining the ground rules for the systematic optimisation of nanowire sensor design as well as the techniques for batch fabrication. The resultant discoveries will pave the way for improved nanosensor stability and device reproducibility — taking the technology a decisive step closer to commercialisation. A*STAR - University of Washington The Institute of Microelectronics (IME), a research institute of A*STAR and University of Washington‘s (UW) Department of Electrical Engineering entered into a research collaboration to develop a parallel assembly technique to accurately and efficiently assemble ultrathin chips; a three-dimensional (3D) Micro-Electro-Mechanical-Systems (MEMS) high density capacitor with increased energy storage for portable systems; and a microsensor that detects human dehydration levels. 27 OUTLOOK FOR THE NEXT FISCAL YEAR This year, Singapore celebrates 20 years of S&T planning and investment. Since the first five-year S&T plan was launched in 1991, Singapore‘s R&D landscape has grown in strength and diversity. The investment in R&D by the Singapore government remained despite the global economic crisis of 2008-2009, and has positioned Singapore well to seize the opportunities opening up in Asia today. The Singapore government remains committed to its investment in research and innovation, which are key pillars in its economic strategy. Chairman of the Research, Innovation and Enterprise Committee (RIEC), Prime Minister Lee Hsien Loong, announced in September 2010 that $16.1 billion will be allocated to support research, innovation and enterprise for the next five years (RIE2015). The government will seek to leverage the investment to grow the Gross Expenditure on R&D (GERD) to 3.5% by 2015. Singapore‘s long-term aim is to be among the most research-intensive, innovative and entrepreneurial economies in the world, in order to create high-value jobs and prosperity for Singaporeans. $6.39 billion of the RIE2015 budget has been allocated to A*STAR. As Singapore‘s primary mission-oriented research agency, A*STAR is committed to achieving the government‘s RIE2015 goals through supporting research with economic outcomes that will sustain Singapore‘s key economic clusters, as well as capture growth through emerging industries. A*STAR will continue to be at the forefront of scientific excellence, and lead in innovative R&D that are aligned to industry needs. For the MNCs, A*STAR will integrate its capabilities across the disciplines for a concierge approach to attract and anchor MNC activities in Singapore. For local enterprises, A*STAR will continue to gear them for growth, through upgrading their technological capabilities and hence their ability to offer better products and services. In addition, A*STAR will aim to provide a supportive ecosystem to seed surprises that may come in the form of enterprising startups and spin offs from our research community. A*STAR‘s impact on industry will also encompass increased efforts to commercialise research outcomes. As such, budget allocations for Exploit Technologies (ETPL), A*STAR‘s commercialisation arm, will be increased to support more technology transfer activities such as patenting, licensing, and gap funding. In addition, a new multi-agency IP Intermediary has been established to help local enterprises source for or acquire useful IP or technologies so as to expand their innovation capacities and improve their businesses. A*STAR‘s next phase of talent development is to develop itself as a global nexus for local and international scientific talent, so as to create a unique, vibrant and multidisciplinary environment for innovation to thrive. A*STAR will continue to train and develop a pipeline of local scientific talent, while diversifying our talent pool through international programmes aimed at attracting scientists and students from non-traditional talent sources. For many of A*STAR‘s scholars returning to Singapore from their studies from 2011 onwards, A*STAR will embark on focused career development efforts that will help provide them with a rewarding and fulfilling career in their chosen paths. A*STAR‘s strategies for the next five years will help Singapore truly realise its vision of becoming Asia‘s Innovation Capital. 28