Experience Excellence - Orthopaedic Research Society
advertisement
2012 ANNUAL MEETING Experience Excellence February 4 - 7, 2012 Moscone West Convention Center San Francisco, California PROGRAM BOOK GET CONNECTED… Make myORS.org your ultimate ORTHOPAEDIC RESEARCH DESTINATION. Create communities and discussion groups, forge collaborations and much more... Launching www.myORS.org in February! A NEW ORS MEMBER BENEFIT! BE THE FIRST ONE TO CHECK IT OUT. WELCOME TO THE 2012 ANNUAL MEETING Thank you to Jacob Elkins, MS and Kristin Moffat, PhD, for allowing the ORS to use their work on the front cover of this year’s ORS Annual Meeting Program Book. The work is from the following studies: Total Hip Instability in the Morbidly Obese Patient: A Finite Element Exploration. Elkins, Jacob; Pedersen, Douglas; Callaghan, John J. and Brown, Thomas D. Jacob Elkins was the recipient of the 2011 William H. Harris, MD Award In Vitro and In Vivo Evaluation of a Bi-Phasic Nanofiber Scaffold for Integrative Rotator Cuff Repair. Moffat, Kristen L.; Zhang, Xinzhi; Greco, Stephanie; Boushell, Margaret B.; Guo, X. Edward; Doty, Stephen B.; Soslowsky, Louis J.; Levine, William N. and Lu, Helen H. Kristen L. Moffat was the recipient of a 2011 NIRA Award. Absolutely no photography, video, audio recording or reproduction of any kind may be used during any portion of the 2012 Annual Meeting. The ORS reserves all of its rights to such materials, and commercial recording or reproduction is specifically prohibited. This includes, but is not limited to digital and film photography, videography, cellular phones, and other image or audio recording devices. This policy will be strictly enforced. SPECIAL NOTE: As a registrant, you agree to ORS’ use of your likeness captured by the official show photographer in any future promotional materials. Welcome to the ORS 2012 Annual Meeting Saturday, February 4 – Tuesday, February 7, 2012 Moscone West Convention Center • San Francisco, California Dear Fellow ORS Members, Colleagues, and Guests, On behalf of the Orthopaedic Research Society, we welcome you to the ORS 2012 Annual Meeting in San Francisco, California. Many members are involved in the development of the ORS Annual Meeting. Our Program Committee, Topic Chairs and more than 200 volunteer abstract reviewers work to assemble the best research presentations into podium and poster sessions. We would like to specifically recognize the efforts of Joan Bechtold and the members of the 2012 Program Committee in putting together a dynamic program, and the members of the Annual Meeting Committee for overall meeting organization. Of course, none of this would be possible without our very dedicated, professional staff. At the 2012 meeting we will continue to address the educational and professional development interests of our attendees through our professional advancement series, co-sponsored symposia and workshops, technical exhibits, industry-related events, research interest groups, mentoring opportunities, and more. In particular, we are dedicated to the development of future researchers and clinician-scientists, through the training and mentoring of post-doctoral fellows, orthopaedic residents, and graduate students. To this end, we will be offering a new program–the Poster Walking Tours. Experienced investigators will conduct walking tours of posters in their areas of expertise. Back by popular demand are the Spotlight Sessions, with invited experts in various fields presenting their work in themed sessions. We will also offer the Clinical Research Forum that was introduced at last year’s annual meeting. This one-day research forum is intended to cover topics related to the design, analysis, and trouble-shooting of clinical research. This year’s theme is ”The innovation cycle: how can we avoid wrong turns?” This research forum will run in parallel with our other programming on Monday, February 6th. The 2012 meeting is co-located with the American Academy of Orthopaedic Surgeons Annual Meeting in the Moscone Convention Center. ORS and AAOS meeting badges will allow attendees access to sessions at either meeting on Tuesday the 7th and allow ORS attendees into the AAOS meeting and Exhibition Hall on Wednesday the 8th. The co-located meeting comes with some space constraints that necessitate having two poster sessions. We want your feedback on this and all other aspects of the meeting; so please answer the meeting survey. We thank you for your support of the ORS, and hope you experience excellence at the meeting and in San Francisco-one of the world’s top destination cities. Sincerely, Brian Johnstone, PhD ORS President Ted Miclau, MD Chair, ORS Annual Meeting Committee Table of Contents Annual Meeting Corporate Partners.....................................................................Page 4 Table of Contents Posters & Exhibits................................................................................................ Page 5 Professional Advancement Series.......................................................................Page 6 Mentoring/RIGs.................................................................................................... Page 7 ORS Award Presentations / Presidential Address................................................Page 8 ORS/AAOS Co-Programming..............................................................................Page 9 Kappa Delta & OREF Clinical Research Award Presentations..........................Page 10 ORS Keynote Speaker/Incoming Presidential Address......................................Page 10 Registration/Travel Information.......................................................................... Page 11 General /Meeting Information.............................................................................Page 13 Membership Information . ........................................................................... Pages 14-15 Membership Applications............................................................................. Pages 17-22 Education Workshops/Professional Advancement Series Saturday, February 4........................................................................... Pages 25-26 Sunday, February 5............................................................................. Pages 39-41 Monday, February 6............................................................................ Pages 52-53 Tuesday, February 7........................................................................... Pages 61-62 Scientific Paper Sessions Saturday, February 4........................................................................... Pages 27-37 Sunday, February 5............................................................................. Pages 42-49 Monday, February 6............................................................................ Pages 54-59 Tuesday, February 7................................................................Pages 64-65, 67-68 ORS/AAOS Combined Symposia.............................................................Pages 63 & 66 Poster Sessions ....................................................................................... Pages 69-169 Exhibitor Listing and Floor Plan...............................................................Pages 171-178 Floor Plans of the Moscone West Convention Center........................ Inside Back Cover Brian Johnstone, PhD ............................................................................... President Theodore Miclau, MD ................................................................ First Vice President Joan E Bechtold, PhD ..........................................................Second Vice President Mary B Goldring, PhD ..............................................................Third Vice President Mathias P Bostrom, MD .........................................................Fourth Vice President General Information Orthopaedic Research Society Board of Directors 2011 – 2012 Clare Rimnac, PhD . ........................................................ Immediate Past President Martha L Gray, PhD . .................................................................................Secretary Jennifer S Wayne, PhD .............................................................................Treasurer Edward M Schwarz, PhD ............................................................. Member-At-Large Michael J Yaszemski, MD, PhD . .................................................. Member-At-Large Niamh Nowlan, PhD ..................................................................... Member-At-Large John Antoniou, MD, PhD .......................................... Membership Committee Chair Joseph M Lane, MD ............................................. Society Liaison Committee Chair Marjolein van der Meulen, PhD .......................................Secretary-Elect, Ex-officio Henry J Donahue, PhD ............................................ Editorial Advisory Board Chair Annual Meeting Committee Program Committee Theodore Miclau, MD Joan E Bechtold, PhD, Chair Joan E Bechtold, PhD Mary B Goldring, PhD, Poster Chair Serena S Hu, MD Mathias P Bostrom, MD Joseph M Lane, MD Evan L Flatow, MD James J Mason, PhD Scott Tashman, PhD Harry A McKellop, PhD Jennifer J Westendorf, PhD Larry Suva, PhD Orthopaedic Research Society Staff Brenda A Frederick....................................................................... Executive Director Alyson Bialek..............................................................................Society Coordinator Mary Jo Harrold.......................................................................Meetings Coordinator Annie C Hayashi................................. Development and Communications Manager Mary Jo Heflin............................................................................. Education Manager Jola Lewsza................................................. Professional Development Coordinator Matt Zuleg............................................................Membership Services Coordinator 1 Topic Chairs The ORS Board of Directors, Annual Meeting and Program Committees would like to acknowledge the Topic Chairs for their contribution to the 2012 Annual Meeting Program. Topic Chairs CHAIR TOPIC John S Adams, MD............................................................................................................................Bone Steven Boyd, PhD ..................................................Imaging and Diagnostics Tissue and Organ Imaging Susanna G Chubinskaya, PhD...................................................................Cartilage/Meniscus/Synovium Darryl D D’Lima, MD............................................................................................................... Arthroplasty Hank Donahue, PhD............................................................................. Cell and Molecular Biomechanics Hicham Drissi, PhD.............................................................................Skeletal Growth and Development Dan Gazit, PhD, DMD .................................................................................. Progenitors and Stem Cells Louis C Gerstenfeld, PhD.............................................................................................................Fracture Daniel A Grande, PhD ..................................................................................................................... Spine Gloria Gronowicz, PhD......................................................................................................................Bone Ranjan Gupta, MD........................................................................................................... Upper Extremity Warren O Haggard, PhD ....................................................................................... Biomaterials - Bioinert Alan R Hargens, PhD ......................................................................................................... Muscle/Nerve Edward J Harvey, MD . .................................................................................................................Trauma James C Iatridis, PhD....................................................................................................................... Spine John D Kisiday, PhD . ................................................................................................ Tissue Engineering Francis Y Lee, MD . .........................................................................................................Cancer, Tumors Marc E Levenston, PhD ............................................................................Cartilage/Meniscus/Synovium Sheldon Lin, MD . ............................................................................................................. Foot and Ankle Christopher B Little, DVM . ........................................................................Cartilage/Meniscus/Synovium Helen Lu, PhD............................................................................................................ Tissue Engineering Suzanne A Maher, PhD .......................................................................................Biomaterials - Bioactive Kenneth A Mann, PhD ......................................................................... Hip and Knee – Disease Process Jay Parvizi, MD ..................................................................................................................... Arthroplasty Geoff Richards, PhD........................................................................................ Infection and Inflammation Stavros Thomopoulos, PhD ........................................................................................... Upper Extremity Li-Qun Zhang, PhD ................................................................................................. Gait and Kinematics Chunfeng Zhao, MD.......................................................................................................Tendon/Ligament 2 The ORS Board of Directors and Program Committee would like to thank all the volunteers for their time, effort, and dedication to the Society and the 2012 Annual Meeting. Joseph A Abboud, MD Douglas J Adams, PhD Adetola B Adesida, PhD Animesh Agarwal, MD Mohammed P Akhter, PhD Toshihiro Akisue MD Ozan Akkus, PhD Mauro R Alini, PhD Andrew E Anderson, PhD Donald D Anderson, PhD Gunnar BJ Andersson, MD, PhD Valentin Antoci, MD, PhD Suneel S Apte, MD, PhD Hani A Awad, PhD Scott A Banks, PhD Mary F Barbe, PhD George L Barnes, PhD Thomas W Bauer, MD, PhD Judith F Baumhauer, MD Joan E Bechtold, PhD Nicky Bertollo, PhD Michael J Bey, PhD Fabrizio Billi, PhD Hatice Bodugoz-Senturk, PhD Mathias P Bostrom, MD Mary L Bouxsein, PhD Barbara D Boyan, PhD John B Brunski, PhD William Bugbee, MD Susan V Bukata, MD David B Burr, PhD Sharon Byers, PhD Jarrett Cain, MS John J Callaghan, MD Alesha B Castillo, PhD Nadeen O Chahine, PhD Srinivasan Chandrasekhar, PhD Pen-Hsiu (Grace) Chao, PhD Chaoyang Chen, MD Chaoyang Peter Chen, PhD Louis Wing Hoi Cheung, PhD Blaine A Christiansen, PhD Deborah M Ciombor, PhD Andrea Clark, PhD Celine I Colnot, PhD Clifford W Colwell Jr., MD Magali Cucchiarini, PhD Quanjun (Trey) Cui, MD John H Currier, MS Chitra Lekha Dahia, PhD Timothy Damron, MD David D Dean, PhD Richard E Debski, PhD Mehul Dharia, MS Paul E DiCesare, MD Randall L Duncan, PhD Alan Eberhardt, PhD Edward Ebramzadeh, PhD John J Elias, PhD Motomi Enomoto-Iwamoto, DDS Alejandro A Espinoza Orias, PhD Christopher H Evans, PhD Cornelia E Farnum, DVM, PhD Sara J Farquhar, PhD Russell J Fernandes, PhD David M Findlay, PhD Carl R Flannery, PhD Evan L Flatow, MD Francisco Forriol, MD, PhD Amanda J Fosang, PhD Mark R Foster, MD, PhD Susannah P Fritton, PhD Simon P Frostick, MD Michael J Gardner, MD Zulma Gazit, PhD Damian Genetos, PhD Katy Georgiadis, PhD Burhan Gharaibeh, PhD Michelle A Ghert, MD Steven Ghivizzani, PhD Gary Gibson, PhD Julie Glowacki, PhD Vijay K Goel, PhD Jessica E Goetz, PhD Mary B Goldring, PhD Said T Gomaa, PhD Sibylle Grad, PhD Warren L Grayson, PhD Ed M Greenfield, PhD A Seth Greenwald, DPhil (Oxon) Shawn Grogan, PhD Marc D Grynpas, PhD X Edward Guo, PhD Mark W Hamrick, PhD Bo Han, PhD David Hart, PhD Masahiro Hasegawa, MD, PhD Robert S Hastings, MS Karen A Hasty, PhD Dominik R Haudenschild, PhD James Hayden, MD, PhD Scott J Hazelwood, PhD John H Healey, MD Christopher J Hernandez, PhD Lizeth Herrera, BS Bang H Hoang, MD Mark C Horowitz, PhD William A Horton, MD Judith Hoyland, PhD Adam H Hsieh, PhD Johnny Huard, PhD Clark T Hung, PhD Mark Hurtig, DVM Shepard R Hurwitz, MD Hiromu Ito, MD Keita Ito, MD Rita Kandel, MD Lu Kang, PhD Hiroshi Kawaguchi, MD Mamoru Kawakami, MD Richard K Kdolsky, MD Hua Z Ke, MD Keith Kenter, MD Mark A Kester, PhD Joyce H Keyak, PhD Hyun-Min (Mike) Kim, MD Young-Jo Kim, MD, PhD Thorsten Kirsch, PhD Jenneke Klein-Nulend, PhD Akio Kobayashi, MD Janet L Krevolin, PhD Catherine K Kuo, PhD Steven M Kurtz, PhD Joseph M Lane, MD Michael Lavagnino, PhD Eric Ledet, PhD Francis Y Lee, MD Thay Q Lee, PhD Jack E Lemons, PhD Clifford M Les, DVM, PhD Bingyun Li, PhD Jiliang Li, MD, PhD Wan-Ju Li, PhD Jane B Lian, PhD Fang Amanda Lin Guoan Li, PhD Alan S Litsky, MD Chuanju Liu, PhD Xiaowei Sherry Liu, PhD Richard F Loeser, Jr, MD Hongbin Lu, PhD Hue H Luu, MD Karen M Lyons, PhD Mahomed Mahfouz, PhD Robert J Majeska, PhD Henrik Malchau, MD Anne-Marie Malfait, MD Kenneth A Mann, PhD Jeremy Mao, PhD Ralph Marcucio, PhD Ivan Martin, PhD Robert L Mauck, PhD Audrey McAlinden, PhD Harry A McKellop, PhD Alexander C McLaren, MD Christopher L Mendias, PhD James D Michelson, MD Elise F Morgan, PhD Michael D Morris, PhD Xiaodong Mu, PhD Peter Muir, PhD Orhun K Muratoglu, PhD Martha M Murray, MD Fackson Mwale, PhD Takanobu Nakase, MD Raghu N Natarajan, PhD Fred R T Nelson, MD Steven B Nicoll, PhD Glen L Niebur, PhD Syam P Nukavarapu, PhD Jeffry S Nyman, PhD Grace D O’Connell, PhD Kjell S Olmarker, MD, PhD Mike S Ominsky, PhD Hironobu Oonishi, MD Maurizio Pacifici, PhD Shantanu Patil, MS Ming Pei, MD, PhD Gadi Pelled, PhD Pamela L Plouhar, PhD Fabian E Pollo, PhD Hollis Potter, MD Christopher Price, PhD Yi-Xian Qin, PhD Thomas M Quinn, PhD Amos Race, PhD Michael J Raschke, MD, PhD Anthony Ratcliffe, PhD A Hari Reddi, PhD Weiping Ren, MD, PhD Clare M Rimnac, PhD Makarand V Risbud, PhD Pamela G Robey, PhD Ryan K Roeder, PhD David Rowe, MD Paul J Rullkoetter, PhD Robert L Sah, MD, PhD John Sandy, PhD Bruce J Sangeorzan, MD Hirotaka Sano, MD Carla R Scanzello, MD, PhD Thomas A Schildhauer, MD Gerhard Schmidmaier, MD, PhD Edward M Schwarz, PhD Kotaro Sena, DDS, PhD Irving Shapiro, PhD Peter F Sharkey, MD Theo Smit, PhD Thomas L Smith, PhD Stephen Spiegelberg James B Stiehl, MD Martin Stoddart, PhD Esther J Tanck, PhD Scott Tashman, PhD Johnna S Temenoff, PhD Weidong Tong, PhD Riichiro Tsukamoto, MD Gangadhar Utturkar, MS Thomas P Vail, MD Douglas W Van Citters, PhD Amarjit S Virdi, PhD Nam V Vo, PhD Gordana Vunjak-Novakovic, PhD Steve Waldman, PhD Joseph Wallace, PhD James H Wang, PhD Jinxi Wang, MD, PhD Vincent Wang, PhD Sam Ward, PhD Jennifer Westendorf, PhD J Mark Wilkinson, PhD John L Williams, PhD Sophie Williams, PhD Nicole A Wilson, PhD Gregory R Wohl, PhD Tishya Wren, PhD Cory J Xian, PhD Chao Xie, MD Wentian Yang, MD, PhD Yunzhi (Peter) Yang, PhD Yener N Yeni, PhD Shinichi Yoshiya, MD Xinping Zhang, PhD Xudong Zhang, PhD Zijun Zhang, MD, PhD Adjunct Reviewers Adjunct Reviewers 3 General Information 4 Annual Meeting Corporate Partners The Orthopaedic Research Society would like to thank the following corporate partners for contributions to the ORS 2012 Annual Meeting. Posters and Exhibits Saturday, February 4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 am – 6:00 pm Sunday, February 5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8:00 am – 4:30 pm Monday, February 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9:00 am – 6:00 pm Tuesday, February 7. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 11:45 am Poster Session I Poster Session II Authors available to answer questions Authors available to answer questions Even numbered posters 4:15 pm – 5:05 pm Even numbered posters 4:00 pm – 5:00 pm Odd numbered posters 5:05 pm – 6:00 pm Odd numbered posters 5:00 pm – 6:00 pm Sunday, February 5 12:00 pm – 1:30 pm 3:00 pm – 4:30 pm Tuesday, February 7 7:00 am – 8:00 am 10:45 am – 11:45 am Saturday, February 4 12:00 pm – 1:30 pm 4:15 pm – 6:00 pm Monday, February 6 12:15 pm – 1:30 pm 4:00 pm – 6:00 pm Posters and Exhibits Poster and Exhibit Hours NEW! A sign-up sheet will be posted on each board. Authors will indicate when they will be at their poster to answer questions during the dedicated poster hours. The two evening poster sessions are mandatory for ALL authors to stand at their poster. NEW!– Poster Walking Tours Saturday, February 4. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12:00 pm – 1:30 pm Sunday, February 5. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3:00 pm – 4:00 pm Monday, February 6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12:15 pm – 1:15 pm Tuesday, February 7. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7:00 am – 8:00 am Join experienced investigators who enjoy communicating about great science as they conduct walking tours of the 2012 Annual Meeting posters. Tours will be offered for biologists, engineers and clinicians on a broad range of poster topics. If you did not register for a tour, please check at the registration desk for availability. Attendees will meet at the entrance to the Poster/Exhibit Hall on Level Three. 5 PROFESSIONAL ADVANCEMENT – ALL REQUIRE PRE-REGISTRATION PROFESSIONAL ADVANCEMENT Room 2002 Professional Advancement Series I: Deciding what Journal to Publish in? Saturday, February 4 8:00 am – 9:30 am Organized by the ORS Membership, New Investigators Mentoring, Special Projects Committees, and the ORS Women’s Leadership Forum Prominent editors of leading Journals representing various disciplines will share their perspectives on the decision making process of which journal to publish in. Do’s and don’ts of the submission process will be discussed. Also, a lecture will be dedicated to the topic of paper authorship. Registration is required. Targeted to graduate students, residents, and post-doctoral fellows. Room 2002 Professional Advancement Series II: Optimizing Skills Needed For A Successful Research Career Sunday, February 5 8:00 am – 9:30 am Organized by the ORS Membership, New Investigators Mentoring, Special Projects Committees, and the ORS Women’s Leadership Forum This interactive session will provide you with practical ideas to effectively communicate key messages about your research to non-academic audiences including the media; assist you in finding ways to seek research funding when the initial request may not be granted. Finally, recent recalls in the orthopaedic industry has called into question how new innovations should be introduced into clinical practice. Registration is required. Targeted to post-doctoral fellows, researchers/ clinicians early in their career. Room 2002 Professional Advancement Series III: Entrepreneurship for Academics in Orthopaedics: How to Get an Idea Out of the University Monday, February 6 8:00 am – 9:30 am The usual orthopaedic technical training and research training programs (for example BS, MS, PhD, post-doc and MD) rarely give insight into entrepreneurship in the fields related to orthopaedics. While much of the orthopaedic device industry is well established, mature and highly profitable, continued innovation will be required to address the changing needs and increasing expectations of patients in the near and distant future. Academic research is often touted as the birthplace of these needed innovations. However, in order for these innovations to reach fruition, these ideas and innovations must be successfully transplanted from academia into industry and grown into successful products. In this program, speakers will discuss their own experiences with entrepreneurship and the challenges associated with translating academic research into products. Registration is required. 6 – all programs require pre-registration Level 3, Exhibit Hall Meet the Mentors Luncheon Sunday, February 5, 2012, 12:00 pm – 1:30 pm Sponsored by the ORS New Investigators Mentoring Committee ($30 member; $35 non-member, includes lunch) The “Meet the Mentors” luncheon is designed to provide advice to new investigators and researchers on how to consider issues related to establishing an independent research career and balancing competing demands in the academic and corporate environments. The discussions will also focus on the importance of identifying mentors and describing the roles and functions of a mentor. Three participants will be assigned to one mentor. Attendees will be assigned to tables based on their areas of interest and will be able to pick the mentors they would like to meet. The sessions are intended to be informal, interactive, and designed for all to actively participate in the discussions. Mentors are from North America. Potential topics may include: • Selecting mentors • What mentors do to assist junior faculty and team members • Writing your first grant • Departmental status for clinician scientists • Research versus management track options in industry • Relationships within the department • Expectations of the job • Creating an impact • Measures of success Registration is on a first-come, first-served basis. ORS Women’s Leadership Forum Award and Networking Reception E&O Trading Company Sunday, February 5 7:30pm-9:00pm ($65 for ORS members and $80 for ORS non-members— includes reception, cash bar will be available) Organized to prepare women for leadership in the ORS and to mentor and foster young women in orthopaedic research, the ORS Women’s Leadership Forum (WLF) seeks to• encourage and inspire women early in their careers; • increase the number of women receiving training in orthopaedic research, specifically in the fields of engineering, biology and orthopaedic surgery. Join this fast-growing, dynamic group for an opportunity to meet and network with many prominent ORS leaders. – pre-registration is required Alcoves 2 & 3, Level 3 Exhibit Hall Meet the Industry Members Luncheon Monday, February 6 12:15 pm – 1:30 pm Organized by the ORS Corporate Affairs Committee ($30 for ORS member, $35 for non-members; includes lunch) The ORS Corporate Affairs Committee invites you to attend the Meet the Industry Members Luncheon. This luncheon and networking session is open for ORS attendees affiliated with industry or interested in working in/with industry. The purpose is to have an interactive discussion with industry colleagues and to meet with Corporate Affairs Committee members to learn how the Society can support industry members and provide additional services and benefits. ORS invited speakers of the Professional Advancement Series III – Entrepreneurship for Academics in Orthopaedics: How to Get an Idea Out of the University to attend the luncheon as well. Registration is required. RESEARCH INTEREST GROUPS Sunday, February 5 6:30 am - 7:30 am Room 2006 An Update on Research Topics and Future Directions in Intervertebral Disc Research Organizers: Fackson Mwale, PhD; Daisuke Sakai, MD, PhD; Sibylle Grad, PhD; Makarand Risbud, PhD, and Rita Kandel, MD, and Peter J. Roughley, PhD Room 2014 Growth Factors Organizer: Stephen Trippel, PhD Tuesday, February 7 6:30 am - 7:30 am MENTORING / RIGS MENTORING Room 2006 Bone Tissue: Hierarchical Simulations of Bone for Clinical Application Organizer: Maria-Grazia Ascenzi, PhD Room 2002 Graduate Student Women’s Group Organizers: Tina Nagel and Amy Claeson Room 2014 The Orthopaedic Evidence and Outcomes Education Organization Organizer: Michael Dohm, MD, ABOS, FAAOS 7 SPECIAL PROGRAMS OF THE ORS SPECIAL PROGRAMS NEW! Saturday, February 4, 3:15 pm – 4:15 pm New Investigator Recognition Award Paper Presentations For the first time, the New Investigator Recognition Award (NIRA) finalists will present their papers, followed by question and answer sessions. The thirty-five NIRA presentations will be given in groups of eight presenters, with five-minute talks followed by tenminute discussions. New Investigator Recognition Award Paper Presentations. See page 35. AWARDING EXCELLENCE ORS Awards and Presidential Address Monday, February 6, 9:45 am – 11:00 am Moscone West Convention Center, Room 2005 Moderators: Harry McKellop, MD, Chair, ORS Awards and Recognition Committee, Brian Johnstone, PhD, ORS President, and Mary Goldring, PhD, ORS 2012 Annual Meeting Poster Chair. MEMBERS ONLY ORS Annual Business Meeting Monday, February 6, 2012, 7:00 am – 8:00 am Room 2006 Monday, February 6, 2012, 8:00 am – 4:30 pm Clinical Research Forum: The Innovation Cycle: How Can We Avoid Wrong Turns? Co-Chairs: Theodore Miclau, MD, Mohit Bhandari, MD Program Committee: James G. Wright MD, George Muschler MD, Kristy Weber MD, Saam Morshed MD. See Page 51. Pre-registration is required The ORS/OREF Distinguished Investigator Award Thomas A. Einhorn, MD Boston University Medical Center Boston, MA The ORS Women’s Leadership Forum Award Barbara D. Boyan, PhD Georgia Institute of Technology Atlanta, GA ORS Awards Presentations AWARDING EXCELLENCE The prestigious ORS Awards will be given to individuals with significant contributions to the advancement of orthopaedic research and furthering understanding of the musculoskeletal system and musculoskeletal diseases and injuries. Highly distinguished researchers, leaders and mentors will be honored. The William Harris Award ORS New Investigator Recognition Awards (NIRAs) The Marshall R. Urist Award Jonathan H. Rylander, MS Stanford, CA Functional Testing Provides Unique Insights into the Pathomechanics of Femoroacetabular Impingement and Joint RR&D Frank Barry, PhD National University of Ireland Galway, Ireland To be announced ORS/OREF Travel Awards in Orthopaedic Research Translation The ORS Alfred R. Shands Jr., MD Award and Lecture Gunnar B.J. Andersson, MD, PhD Rush University Medical Center Chicago, IL The ORS Arthur Steindler, MD Award Samuel B. Adams, Jr., MD Eiji Kozawa, MD Carla Scanzello, MD, PhD Aasis Unnanuntana, MD ORS Collaborative Exchange Award Recipients Evelyn Birmingham, BE 8 Damian Genetos, PhD David R. Eyre, PhD University of Washington Seattle, WA ORS Presidential Address Brian Johnstone, PhD ORS/AAOS Co-Programming • ORS/AAOS Combined Symposium I: Adverse • • Reactions to Byproducts of Joint Replacement ORS/AAOS Combined Symposium II: Basic and Clinical Science Advances in Understanding Femoroacetabular Impingement (FAI) Kappa Delta Award Paper Presentations/OREF Research Award Seven AAOS posters will be highlighted at the ORS meeting (Saturday – Tuesday.) The AAOS will choose one poster from each of the common classifications: Adult Hip, Adult Knee, Foot and Ankle, Hand and Wrist, Shoulder and Elbow, Tumors, and Spine. ORS will have seven posters highlighted at the AAOS meeting (Tuesday – Saturday) from the same categories. ORS will also present the ten New Investigator Recognition Award winning posters at the AAOS meeting. HOW TO GET AN AAOS BADGE? ORS registrants will be able to attend the AAOS meeting on Tuesday and Wednesday, which includes access to the AAOS exhibit hall on Wednesday. ORS registrants interested in attending the AAOS meeting must visit the ORS registration desk before 2:00 pm Tuesday to receive a complimentary AAOS badge. AAOS ticketed courses or sessions will require an additional fee. AAOS Program Schedule 8:00 am – 6:00 pm Academy Hall - Posters, Scientific Exhibits, Multimedia Education 8:00 am – 10:00 am Papers, Symposia 8:00 am – 11:00 am Hand, Spine and Sports Medicine Review Courses 10:30 am – 12:30 pm Instructional Course Lectures, Papers, Symposia 1:30 pm – 3:30 pmInstructional Course Lecture, Papers, Symposia 1:30 pm – 6:00 pm Instructional Course Lecture 4:00 pm – 6:00 pm Instructional Course Lectures, Papers, Symposia Room 2005, 1:00 pm – 2:30 pm ORS/AAOS Combined Symposium I Adverse Reactions to Byproducts of Joint Replacement Moderators: Juan J Rodrigo, MD and Stuart B Goodman, MD, PhD This symposium describes antigen-specific (allergic) inflammatory responses to byproducts of joint replacements including histological findings, lymphocyte proliferative responses, radiological and clinical presentations, and methods of antigen testing. Clinical Manifestations of Metal Allergy Joshua J Jacobs, MD Basic Immunological Principles of Allergy for the Orthopaedic Surgeon Paul H Wooley, PhD The Non-Specific Response to Byproducts of Total Joint Implants Stuart B Goodman, MD, PhD Testing for Patients for Immune Response/Allergy Nadim J Hallab, MD Histological Aspects of Metal Allergies Patricia A Campbell, PhD Local Reactions to Metal-on-Metal Implants Young-Min Kwon, MD, PhD ORS/AAOS Co-Programming ORS/AAOS CO-PROGRAMMING Room 2005, 2:45 pm – 4:15 pm ORS/AAOS Combined Symposium II Basic and Clinical Science Advances in Understanding Femoroacetabular Impingement (FAI) Moderator: John C Clohisy, MD This combined AAOS and ORS symposium will address the current, contemporary understanding of FAI and will propose areas in need of future investigation. Specifically, the current evidence supporting the concept of FAI will be reviewed. The scientific information regarding hip pathomechanics, disease epidemiology, and prevalence of FAI will be presented. Contemporary strategies for disease stagings including radiography, imaging and biomarkers will be discussed. The current evidence regarding surgical treatment will be analyzed and presented with emphasis on identifying areas in need of investigation. Overall, this symposium will present the current basic and clinical science evidence regarding FAI, contemporary strategies of diagnosis, disease staging and treatment. An emphasis will also be placed on future areas of basic and clinical science investigation. Pathomechanics of FAI Christopher L Peters, MD Disease Epidemiology and Prevalence Michael Leunig, MD Disease Staging-Radiography and Advanced Imaging Paul Beaule, MD Open Surgical Treatment of Surgical Femoroacetabular TreatmentCurrent Evidence and Treatment Results Ernie Sink, MD Less-Invasive Surgical Treatment of FAI Current Evidence and Clinical Results Christopher Larson, MD Disease Staging-Biomarkers of Osteoarthritis and Potential for FAI Disease Staging Linda J Sandell, PhD 9 ORS/AAOS CO-PROGRAMMING Kappa Delta and OREF Clinical Research Award Paper Presentations Tuesday, February 7, 4:30pm – 5:30pm Kappa Delta Sorority has contributed to the advancement of orthopaedics since 1950. The highly coveted orthopaedic research awards through the American Academy of Orthopaedic Surgeons (AAOS) have been the starting point for many prominent researchers and physicians in the field. Beginning with one $1,000 research award in 1950, Kappa Delta now supports three $20,000 grants—the Ann Doner Vaughan Award, the Elizabeth Winston Lanier Award, and the Young Investigator Award—and is dedicated to the future of musculoskeletal health. The Kappa Delta Research Awards call attention to important studies and garner esteemed recognition in the field. A past Kappa Delta Young Investigator Award Recipient put it best: “It’s like the Nobel Prize of Orthopaedics. This serves to inspire young investigators and more experienced investigators to produce larger bodies of cohesive work, which is necessary for successful research programs and advancing the field to enable better treatment options for our patients.” 2012 KAPPA DELTA YOUNG INVESTIGATOR AWARD 2012 KAPPA DELTA ELIZABETH WINSTON LANIER AWARD GDFS Modulation in Intervertebral Disc Degeneration Regional Gene Therapy to Enhance Bone Repair Xudong Joshua Li, MD, PhD 2012 KAPPA DELTA ANN DONER VAUGHAN AWARD Kurt P Spindler, MD Co-Authors: Richard D Parker, MD, Jack T Andrish, MD, Christopher C Kaeding, MD, Rick W Wright, MD, Robert G Marx, MD, MSc, Eric C McCarty, MD, Annunziato Amendola, MD, Warren R Dunn, MD, MPH, Laura J Huston, MS, Frank E Harrell, Jr, PhD Jay R Lieberman, MD 2012 OREF CLINICAL RESEARCH AWARD Thomas D Brown, PhD Co-Authors: Jacob M Elkins, MS, Douglas R Pedersen, PhD, John J Callaghan, MD The Impingement and Dislocation in Total Hip Arthroplasty: Mechanisms and Consequences Prognosis and Predictors of ACL Reconstructions using the MOON Cohort: A Model for Comparative Effectiveness Studies General Session – Keynote Speaker and Incoming ORS Presidential Address General Session 10 Room 2005 Tuesday February 7, 9:45 am – 10:45 am Keynote Speaker - Zena Werb, PhD, Professor and Vice Chair, Department of Anatomy, University of California, San Francisco Molecular Regulation of Tissue Remodeling during Skeletal Development and Regeneration Incoming Presidential Address Theodore Miclau, MD REGISTRATION Membership Status On-site registration will be located in the lobby on Level 3 of The Moscone West Convention Center. The hours are: Friday, February 3 Saturday, February 4 Sunday, February 5 Monday, February 6 Tuesday, February 7 2:00 pm – 5:00 pm 7:00 am – 6:00 pm 7:00 am – 6:00 pm 7:00 am – 6:00 pm 7:00 am – 2:00 pm SPEAKER READY ROOM Room 2001 – Level 2 Hours Friday, February 3, 2:00 pm – 5:00 pm Saturday, February 4, 7:00 am – 5:00 pm Sunday, February 5, 7:00 am – 5:00 pm Monday, February 6, 6:30 am – 5:00 pm Tuesday, February 7, 6:00 am – 5:00 pm TRANSACTION STATIONS/INTERNET CAFE The ORS 2012 Annual Meeting Transaction stations and the Internet Café are located in the Exhibit Hall on Level 3 of the Convention Center. Hours Friday, February 3, 2:00 pm – 5:00 pm Saturday, February 4, 7:00 am – 6:00 pm Sunday, February 5, 7:00 am – 6:00 pm Monday, February 6, 7:00 am – 6:00 pm Tuesday, February 7, 7:00 am – 11:45 am Active Member $395 Affiliate Member $395 Associate Member $195 Emeritus Member $0 Non-Member $695 Orthopaedic Resident/Fellow $285 PhD Candidate/Student $285 ORS CAREER CENTER KIOSKS The ORS Career Center Kiosks are located in the lobby on Level 3 of the Convention Center. The ORS Career Center is the premier recruitment resource for the industry. Here, employers and recruiters can access the most qualified talent pool with relevant work experience to fulfill staffing needs. Job seekers: Whether you’re looking for a new job or ready to take the next step in your career, we’ll help you find the opportunity that is right for you. Employers: Target your recruiting and reach qualified candidates quickly and easily. Simply complete the online registration form and start posting jobs today. Hours Saturday, February 4, 7:00 am – 6:00 pm Sunday, February 5, 7:00 am – 6:00 pm Monday, February 6, 7:00 am – 6:00 pm Tuesday, February 7, 7:00 am – 11:45 am TRAVEL INFORMATION SAFETY TIPS DO: • • • Travel with only the credit card and ID cards you will use. Check that the lock works and that the door closes securely in your hotel room. Put the chain or deadbolt on the door after entering room. Walk with another person. Single targets are the most likely victims of crime. DON’T: • • Wear your badges or carry conference bags outside. Walk in dark, isolated areas, such as closed plazas. TRAVEL INFORMATION ON-SITE REGISTRATION On-Site Registration REGISTRATION REGISTRATION FEE 11 Win this trophy and a travel award to the 2013 ORS Annual Meeting! TO enTeR The ORS VideO OuTReaCh COMpeTiTiOn: ORS Video Outreach Competition First Place The ORS Media Relations & Communications Committee is pleased to announce The ORS Video Outreach Competition • Is your musculoskeletal research novel and exciting? • Do you want to share your work with the public and the media? • Can you creatively translate your work into understandable concepts? • Are you able to make your musculoskeletal research accessible and fun? Then….The ORS Video Outreach Competition is for you! The purpose of the ORS Video Outreach Competition is to encourage orthopaedic researchers to educate the public and media about significant musculoskeletal research topics in very innovative, accessible, understandable, and fun ways! For examples of a similar scientific video contest, please go to YouTube and enter the “Ars Technica Science Video Contest” as search criteria. The first three videos are from the Ars Technica Science Video Contest. Make a video—not to exceed three minutes or 2 GB in length—about your research. Translate complex science using creative methods and easy-to-understand concepts. Employ highly innovative techniques, e.g. animation, high speed cameras, advanced imaging Please do not include cadaveric or animal testing without the approval of the ORS Media Relations and Communications Committee. Record the video in a format that is compatible with YouTube, e.g. MP4. Have institutional approval for the research presented A panel of multidisciplinary musculoskeletal researchers will evaluate videos on their use of innovative methods to translate complex science into easy-to-understand concepts. awaRdS Awards will be presented to the winning individual or team at the 2013 ORS Annual Meeting. The winning videos will be shown at the awards ceremony. Winners will also receive travel awards to the 2013 ORS Annual Meeting. FiRST plaCe: 1st Place trophy and recognition at the 2013 ORS Annual Meeting; first tier travel award included SeCOnd plaCe: 2nd Place trophy and recognition at the 2013 ORS Annual Meeting; second tier travel award included ThiRd plaCe: 3rd Place trophy and recognition at the 2013 ORS Annual Meeting; third tier travel award included Registration for the ORS Video Outreach Competition and details on posting your video will be available on the ORS website following the 2012 ORS Annual Meeting. Go to http://www.ors.org deadline for entries: September 1, 2012 Questions? Contact Annie Hayashi, ORS Development and Communications Manager, at Hayashi@ors.org or 847-430-5025 GENERAL INFORMATION MEETING OBJECTIVES To present the best available research from all disciplines of musculoskeletal research. To promote the exchange of ideas and encourage collaborations in orthopaedic research. To encourage promising and emerging areas in musculoskeletal research, including basic science, education, and research strategies by use of forums, workshops, special sessions and special interest meetings. FDA All drugs and medical devices used in the United States are administered in accordance with Food and Drug Administration (FDA) regulations. These regulations vary depending on the risks associated with the drug or medical device, the similarity of the drug or medical device to products already on the market, and the quality and scope of clinical data available. Some drugs or medical devices demonstrated at this 2012 Annual Meeting of the Orthopaedic Research Society may have not been cleared by the FDA or have been cleared by the FDA for specific purposes only. General Information MEETING INFORMATION The FDA stated that it is the responsibility of the physician to determine the FDA clearance status of each drug or medical device This activity has been planned and implemented in accordance he or she wishes to use in clinical practice. Orthopaedic Research with the Essentials and Standards of the Accreditation Council for Society policy provides that “off label” uses of a drug or medical Continuing Medical Education through the joint sponsorship of the device may be described in the Orthopaedic Research Society’s American Academy of Orthopaedic Surgeons and the Orthopaedic CME activities so long as the “off label” use of the drug or medical Research Society. The American Academy of Orthopaedic device is also specifically disclosed (i.e., it must be disclosed Surgeons is accredited by the ACCME to provide continuing medical that the FDA has not cleared the drug or device for the described education for physicians. purpose). Any drug or medical device is being used “off label” if the described use is not set forth on the product’s approved label. The American Academy of Orthopaedic Surgeons designates this educational activity for a maximum of 34.5 AMA PRA Category 1 DISCLAIMER Credits™. Physicians should only claim credit commensurate with The materials presented at the 2012 Annual Meeting of the the extent of their participation in the activity. Orthopaedic Research Society have been made available by the Orthopaedic Research Society for educational purposes only. Attendees claiming CME from the ORS 2012 Annual Meeting will The material is not intended to represent the only, nor necessarily be required to complete the ORS CME Request Form following best, method or procedure appropriate for the medical situations the meeting in San Francisco. Attendees will need to submit the Form by the due date in order to have the ORS CME added to their discussed, but rather is intended to present an approach, view, statement or opinion of the faculty, which may be helpful to others AAOS Transcript. Requests for CME submitted after the deadline, will not be included on the AAOS Transcript and will receive a CME who face similar situations. The Orthopaedic Research Society disclaims any and all liability for injury or other damages resulting Certificate from the ORS. to any individual attending the meeting and for all claims, which may arise out of the use of the techniques demonstrated therein by such individuals, whether these claims shall be asserted by physician or any other person. No reproduction of any kind, including audiotapes and videotape, may be used in any portion of the ORS Annual Meeting. The ORS reserves all of its rights to such material, and commercial reproduction is specifically prohibited. CONTINUING MEDICAL EDUCATION (CME) CREDIT 13 Become a Member of the Orthopaedic Research Society General Information ORS Membership Committee will be available to discuss membership aspects and benefits as well as endorse applications during breaks and poster sessions in the ORS Booth (#324) located in the Exhibit Hall (Level 3, Moscone West) INFORMATION BENEFITS: Prestige of membership and recognition Reduced registration fees at the ORS Annual Meeting Network of Skilled Professionals Online access to the Transactions of the Annual Meeting Free subscriptions to ORS Society Newsletter and E-News 24-hour access to the Online Membership Directory Discounted rate for ORS Career Center Eligibility for ORS Awards, Fellowships and Grants Subscription to the Journal of Orthopaedic Research (12 issues) Eligibility to serve on ORS Committees, as a reviewer and moderator Active Associate (Student) Affiliate Active Members are elected to the Society based on previous scientific contributions and continued participation in the field of research. Active members pay annual dues of $220. Associate (Student) Membership is available to trainees in the area of orthopaedic research, including individuals who are pursuing advanced degrees (e.g., MD, DDS, DO, MS, , PhD, DVM) or in post-doctoral clinical and research training programs (Residency and Fellowship). Associate (Student) Members must verify their training status in the field of orthopaedic research for membership. Associate (Student) Members are expected to apply for Active membership when their training is completed. Associate (Student) Members pay annual dues of $50. Affiliate Membership is available to lab technicians, lab and private practice administrators/managers, and industry representatives that make a significant scientific and/ or non-scientific contribution to orthopaedic research and the ORS. Applicants must have two institutional sponsors; ORS members must write letters of recommendation including significant scientific and/or nonscientific contribution of the applicant. Letters must to typed on institutional letterhead. Affiliate members pay annual dues of $220. P P P P P P P P P P P P P P P P P P P P P P P P P P Eligibility to serve on Corporate Affairs Committee REQUIREMENTS: 14 P 1. Presentation of a paper at an ORS Annual Meeting OR Publication of two peer-reviewed journals papers related to orthopaedic research. 2. Two ORS sponsors (two letters of recommendation from ORS members, or signatures on the application form. Letters may be sent by mail/e-mail to ors@ors.org. 1. Two ORS sponsors (two letters of recommendation from ORS members, or signatures on the application form. Letters may be sent by mail/e-mail to ors@ors.org. 2. A signature from your Advisor, Dean, Department or Program Chair verifying your training status is required. 1. Attendance at one or more prior ORS Annual Meetings. 2. Two ORS sponsors – two letters of recommendation from ORS Active members are required. Letters of recommendation must address the applicant’s scientific and/or non-scientific contribution to orthopaedic research and must be on institution’s letterhead. Letters may be sent by mail/e-mail to ors@ors.org ACTIVE MEMBERS Samuel Adams, MD Jaimo Ahn, MD, PhD Assen Aleksiev, MD, PhD Kyle Allen, PhD Nelly Andarawis-Puri, PhD Prashant Bansal, PhD Thor Besier, PhD Mohit Bhandari, MD Jeff Bischoff, PhD Katherine Boyer, PhD Lee Breshears, DVM, PhD Darren Brey, PhD John Carrino, MD, MPH Rhima Coleman, PhD Laura Creemers, PhD Yifei Dai, PhD Chitra Dahia, PhD Vinod Dasa, MD Michael Daubs, MD Delphine Dean, PhD Robinder Dhillon, MBBS Anton Dmitriev, PhD Denista Docheva, PhD Troy Drewry, MS Thomas Duquin, MD Lutz Durselen, PhD William Edwards, PhD Saadiq El-Amin, MD, PhD Jutta Ellerman, MD, PhD AFFILIATE MEMBERS Issac Erickson, PhD Amanda Esquivel, PhD Anna Fahlgren, PhD Meghan Faillace, PhD Virginia Ferguson, PhD Clare Fitzpatrick, PhD Hemanth Gadikota, MS Yingxin Gao, PhD Michael Gardner, MD Ian Garrett, PhD Zigang Ge, PhD Adam Hacking, PhD Lisbet Haglund, PhD Matthew Hamilton, PhD Sommer Hammoud, MD Brendan Harley, ScD Robert Havey, BS Carolyn Hettrich, MPH, MD, Howard Hillstrom, PhD Judith Hoyland, PhD Chunlan Huang, MD, PhD Carl Imhauser, PhD Serkan Inceoglu, PhD Wing-Yuk Ip, MD Hanna Isaksson, PhD Paul Issack, MD, PhD Alicia Jackson, PhD Hyung-Min Ji, MD Xiao Bing Jin, MD, PhD Jennifer Elisseeff, PhD ASSOCIATE (student) MEMBERS Abdullah Abbassi, MS Saleem Abubacker, MEng Moshen Akbari –Shandiz, MS Ashley Allen, BS Jeremy Alsup, BS Aja Aravamudhan, MS Sina Babazadeh, MBBS Kristen Barton, MS Sarindr Bhumiratana, MS Anro Bisschop, BS David Black, MD Katerina Blazek, MS Jason Bleedorn, DVM Joel Boerckel, BS Michael Boniello, MS Pelin Candarlioglu, MS Aaron Cannon Jose Canseco Mei Lin Chan, PhD Stephanie Chan, PhD Antonia Chen, MBA, MD Tony Chen, PhD Michael Cross, MD Xiaofeng Cui, PhD Max Davis Nicholas Desy, MD Christopher Dosier, BS Cecilia Dragomir, MD Shannon Edd, BS Youssef Farhat, BS Aaron Fields, PhD Catherine Fritton, BS Joseph Gabra, BS Xueqin Gao, MD, PhD Emily Gardinier, MS Joseph Gardinier, PhD Emmanuel Gibon, MD Susannah Gilbert, MS Bijay Giri, PhD Bo Gong, PhD Peter Govey, BS Stephanie Grenier, PhD Jonathan Gumucio, BS Hongqiang Guo, MS Clare Guterl, PhD Michael Hardisty, MASc Matthew Harmon, BS Hannah Heywood, PhD Anny Hsu, MS Minyi Hu, MS Amira Hussein, MS Joseph Iaquinto, PhD Svenja Illien-Junger, PhD Jason Inzana, MS Chris Jo, MD, PhD Danese Joiner, PhD Ronald June, PhD Subhash Juneja, PhD Deborah Kado, MD Michael Kallos, PhD Amir Kamali, PhD Nobuhiro Kamiya, MD, PhD Narutaka Katoh, MD, PhD Catherine Kirn-Safran, PhD Ching-Chang Ko, DDS, PhD Naoki Kondo, MD, PhD Andreas Kontaxis, PhD Rami Korhonen, PhD Catherine Kuo, PhD Masayuki Kyomoto, PhD Floris Lafeber, PhD Spencer Lake, PhD Mario Lamontagne, PhD Eve Langelier, PhD Sang Yang Lee, MD, PhD Michael Lehmicke, MS Stephen Lemos, MD, PhD Gregory Lewis, PhD Hongshuai Li, PhD Dianne Little, DVM, PhD Xue Cheng Liu, MD, PhD Stefan Lohmander, MD, PhD Jason Long, PhD Russell Main, PhD Milad Masjedi, PhD Helen McCarthy, PhD Kirk McGilvray, PhD Ryan McLemore, PhD Anna Miller, MD Mark Miller, MS Byung-Woo Min, MD, PhD Isaac Moss, MD Lakshmi Nair, PhD Aaron Nauth, MD Valentina Ngai, PhD Takahiro Niikura, MD, PhD Hitoshi Nochi, MD, PhD David Nuckley, PhD Grace O’Connell, PhD Julie O’Connell, PhD Ronke Olabisi, PhD Rema Oliver, PhD Saikat Pal, PhD Ross Palmer, DVM Matthew Pelletier, PhD David Prawel, PhD Ling Qin, PhD Christopher Roche, MS Juan Rodrigo, MD David Rowe, MD Shannon Rowell, BS Dana Ruehlman, DVM Erik Sampson, PhD Carla Scanzello, MD, PhD Thomas Scharschmidt, MD Lisa Schroder, MBA Joel Schwartz, BS Ronen Schweitzer, PhD Neil Segal, MD Ichirio Sekiya, MD, PhD Adam Shimer, MD John Slamin, Eng Margaret Smith, PhD Leo Snel, MS Chia Soo, MD Ajay Srivastava, MD Amber Stern, PhD Mitsuhiko Takahashi, MD, PhD Mia Thi, PhD Steven Tommasini, PhD Gangadhar Utturkar, MS Leonard Valentino, MD Craig Van Kampen, PhD Kartik Varadarajan, PhD Leonard Voronov, MD, PhD Jung-Pan Wang, MD, PhD Julien Wegrzyn, MD, PhD Ye-Yeon Won, MD, PhD Jennifer Woodell-May, PhD Junjie Wu, PhD Cory Xian, PhD Jianwen Xu, PhD Atsushi Yokota, MD, PhD Toshitaka Yoshii, MD, PhD Aliaa Youssef, PhD Tunka Zaman, PhD Yejia Zhang, MD, PhD Jessica May, BS Emily McWalter, PhD Michael Mienaltowski, DVM, PhD Domingo Molina, BS Farrah Monibi, DVM Uche Monu, MS Alyson Morse, BS Athanasia Nikolaou, PhD Saqib Nizami, BS Paul Okagbare, PhD Sunmi Palumbo, PhD Cornelis Paul, MD Frank Johannes Plate, MD Lauren Priddy, MS Devina Purmessur, PhD Ross Radusky Mekhala Raghavan, PhD Daisy Ramos, MS Allison Rao, BA Christopher Raub, PhD Jachun Ro, MS Daniel Roig, PhD Yun Feng Rui, MD Jonathan Rylander, MS Stefan Saevarsson, BS Sambit Sahoo, PhD Christina Salas, MS Nathan Schiele, MS Roshan Shah, MD Anupam Sharma, MS Zhilei Shen, PhD Matthew Soicher, BS Mette Sorense, MD Kirsten Stoner, MEng Tanushree Thote, BS Crystal Tjhia, BS Wei Seong Toh, PhD Ryan Tomlinson, MS Ferenc Toth, DVM, PhD Brent Uhrig, MS Aasis Unnanuntana, MD Rebecca Wachs, MS Kimberly Waller, BS Benjamin Walter, MS Bin Wang, MS Chong Wang, MS Jason Wang, MS Shaobai Wang, MS Wenhai Wang, PhD Nathan Winger, BS Bethany Wilcox, MS Nathan Willet, PhD Samatha Wojda Charlie Yongpravat, MS Xiaozhou Zhou, MS General Information ORS Welcomes New Members that Joined Our Society in 2011 Catherine Muzytchuk Jerome Irianto, MEng Ning Jiang, MS Caroline Jordan, MS Richard Keller, MS Megan Killian, PhD Alison Kitay, MD Karen Kruger, BS Alon Lai, PhD Xiaohan Lai, BS Alex Lambi Kristen Lee, BS Seunghoon Lee, MS Yadin Levy, MD Mon-Tzu Li, BS Wen Li, MS Jeremy Lim, BS Angela Lin, MS Liangjun Lin, MS Carl Lindburg, BS Aranghan Lingham, Bsc Sarah Linley, BS Shane Lloyd, BS Taryn Ludwig, BS Evan Lynch, BS Toran MacLeod, MS Rune Madsen, BS Patrick Marinello Brandon Markway Daniel Massimini, MS 15 Orthopaedic Research Society Application for ACTIVE Membership 6300 North River Road, Suite 602, Rosemont, IL 60018 Phone: 847-823-5770 Fax: 847-823-5772 Email: ors@ors.org (Please Print) Name: ________________________________________________________ ________________________________________________________________________ FIRST LAST MIDDLE INITIAL Institute/Company: ______________________________________________ Department: ____________________________________________________ ______________________________________________________________ ________________________________________________________________________ CITY STREET ________________________________________________________________________ ZIP STATE/PROVINCE Date of Birth: __________________________________________________ COUNTRY MONTH / DAY / YEAR Phone: ________________________ Fax: __________________________ E-mail: ________________________________________________________ Have you previously been a member of ORS? What happened to previous membership? Degree(s): Yes No PhD _____ Year MS _____ Year BS _____ Year Honorary Degree(s) ________________________________________________________ Other Training and Study __________________________________ MD _____ Year ________________________________________________________ Other _________________________________ ________________________________________________________ __________________________________________ Are you certified by the American Board of Orthopaedic Surgery? Yes No If yes, what year? ____________________________ Are you a member of the American Academy of Orthopaedic Surgeons? Yes No Please list your membership(s) in other societies: Present Position(s): ______________________________________ ________________________________________________________ ________________________________________________________ I am a (Please check one): PRIMARY Affiliation (Please check one): SECONDARY Specialization (Please check one): Clinician Academic Basic Science Biologist Industry Applied Science Bioengineer Government Clinical Other General & Administrative Turn page for REQUIREMENTS REQUIREMENTS (These must be met in order for your application to be considered): 1. One of the following: • Presentation of a paper at an ORS Annual Meeting or Year: __________________________________ • Publication of two peer-reviewed journal papers related to orthopaedic research (Please list titles of papers and where they were published or presented): ________________________________________________________________________________________________________ ________________________________________________________________________________________________________ ________________________________________________________________________________________________________ 2. ORS Sponsors: Letters of recommendation. Two letters from ORS members, or signatures on the application form. Letters of recommendation must be submitted to the ORS office either via postal mail or e-mail to ors@ors.org or fax 847-823-5772. It is the applicant’s responsibility to ask ORS members for recommendation letters. Please use the lines below to indicate the ORS members who will write recommendation letters if signatures can not be obtained: 1. Name and signature ____________________________________ ________________________________________ (PRINT NAME) 2. Name and signature ____________________________________ (SIGNATURE) ________________________________________ (PRINT NAME) (SIGNATURE) Please use the checklist below to be sure you have included all necessary materials before sending to the society office: The original application. I have contacted and asked two members of the society to write letters of recommendation or received signatures (as above) on my behalf to be forwarded directly to the ORS office. $245 (U.S. dollars) application fee must be enclosed or the application will be returned – $220 (U.S. dollars) of the fee will be applied to first year’s dues upon acceptance. A check made payable to ORS, in U.S. dollars, drawn on a U.S. bank is enclosed. Please bill my credit card (AMEX, Mastercard, or Visa ONLY). ________________________________________________________ __________________________________________ (NAME ON CARD) (SIGNATURE) ________________________________________________________ __________________________________________ (CREDIT CARD NUMBER) (EXPIRATION DATE) All completed applications should be forwarded to: ORS MEMBERSHIP COMMITTEE 6300 N. RIVER ROAD, SUITE 602 ROSEMONT, IL 60018 Applications for membership are accepted year round. The Membership Committee reviews applications quarterly: March 15, June 15, September 15, and December 15. Applicants are notified about the Membership Committee’s decision within 4–6 weeks of the review date. If you are planning to attend the ORS Annual Meeting, your completed membership application must be received in the ORS office by December 15 to obtain reduced meeting registration rate. Applications received between September 15 and December 15 will be reviewed and billed for the following calendar year. If approved, these applicants will be eligible to obtain the reduced meeting registration rate. Applications received after December 15 will be reviewed for acceptance following the Annual Meeting. Members shall pay annual dues of $220.00, payable in U.S. funds, upon request of the ORS. Active membership dues include a subscription to the Journal of Orthopaedic Research, which is $125.00 of the annual dues. Dues notices are sent out to members each October and can be paid online at www.ors.org. If you have any questions, please contact the ORS office at 847-823-5770 or ors@ors.org. Orthopaedic Research Society Application for ASSOCIATE Membership 6300 North River Road, Suite 602, Rosemont, IL 60018 Phone: 847-823-5770 Fax: 847-823-5772 Email: ors@ors.org (Please Print) Name: ________________________________________________________ ________________________________________________________________________ FIRST LAST MIDDLE INITIAL Institute/Company: ______________________________________________ Department: ____________________________________________________ ______________________________________________________________ ________________________________________________________________________ CITY STREET ________________________________________________________________________ ZIP STATE/PROVINCE Date of Birth: __________________________________________________ COUNTRY MONTH / DAY / YEAR Phone: ________________________ Fax: __________________________ E-mail: ________________________________________________________ Have you previously been a member of ORS? What happened to previous membership? Degree(s): Yes No PhD _____ Year MS _____ Year BS _____ Year Honorary Degree(s) ________________________________________________________ Other Training and Study __________________________________ MD _____ Year ________________________________________________________ Other _________________________________ ________________________________________________________ __________________________________________ Are you certified by the American Board of Orthopaedic Surgery? Yes No If yes, what year? ____________________________ Are you a member of the American Academy of Orthopaedic Surgeons? Yes No Please list your membership(s) in other societies: Present Position(s): ______________________________________ ________________________________________________________ ________________________________________________________ I am a (Please check one): PRIMARY Affiliation (Please check one): SECONDARY Specialization (Please check one): Clinician Academic Basic Science Biologist Industry Applied Science Bioengineer Government Clinical Other General & Administrative Turn page for REQUIREMENTS REQUIREMENTS (These must be met in order for your application to be considered): 1. ORS Sponsors: Letters of recommendation. Two letters from ORS members, or signatures on the application form. Letters of recommendation must be submitted to the ORS office either via postal mail or e-mail to ors@ors.org or fax 847-823-5772. It is the applicant’s responsibility to ask ORS members for recommendation letters. Please use the lines below to indicate the ORS members who will write recommendation letters if signatures can not be obtained: 1. Name and signature ____________________________________ ________________________________________ (PRINT NAME) (SIGNATURE) 2. Name and signature ____________________________________ ________________________________________ (PRINT NAME) (SIGNATURE) 2. A signature from your Advisor, Dean, Department or Program Chair verifying your training status is required. It is required that you request ACTIVE membership status once you have completed your training and have satisfied all membership requirements. __________________________________ (PRINT NAME) ________________________________ ________________________________ (INSTITUTE) (SIGNATURE) Please use the checklist below to be sure you have included all necessary materials before sending to the ORS office: The original application. I have contacted and asked two members of the society to write letters of recommendation or received signatures (as above) on my behalf to be forwarded directly to the ORS office. $50 (U.S. dollars) first year dues must be enclosed or the application will be returned. A check made payable to ORS, in U.S. dollars, drawn on a U.S. bank is enclosed. Please bill my credit card (AMEX, Mastercard, or Visa ONLY). ________________________________________________________ __________________________________________ (NAME ON CARD) (SIGNATURE) ________________________________________________________ __________________________________________ (CREDIT CARD NUMBER) (EXPIRATION DATE) All completed applications should be forwarded to: ORS MEMBERSHIP COMMITTEE 6300 N. RIVER ROAD, SUITE 602 ROSEMONT, IL 60018 Applications for membership are accepted year round. The Membership Committee reviews applications quarterly: March 15, June 15, September 15, and December 15. Applicants are notified about the Membership Committee’s decision within 4–6 weeks of the review date. If you are planning to attend the ORS Annual Meeting, your completed membership application must be received in the ORS office by December 15 to obtain reduced meeting registration rate. Applications received between September 15 and December 15 will be reviewed and billed for the following calendar year. If approved, these applicants will be eligible to obtain the reduced meeting registration rate. Applications received after December 15 will be reviewed for acceptance following the Annual Meeting. Members shall pay annual dues of $50.00, payable in U.S. funds, upon request of the ORS. Dues notices are sent out to members each October and can be paid online at www.ors.org. If you have any questions, please contact the ORS office at 847-823-5770 or ors@ors.org. Orthopaedic Research Society Application for AFFILIATE Membership 6300 North River Road, Suite 602, Rosemont, IL 60018 Phone: 847-823-5770 Fax: 847-823-5772 Email: ors@ors.org (Please Print) Name: ________________________________________________________ ________________________________________________________________________ FIRST LAST MIDDLE INITIAL Institute/Company: ______________________________________________ Department: ____________________________________________________ ______________________________________________________________ ________________________________________________________________________ STREET ________________________________________________________________________ ZIP CITY STATE/PROVINCE Date of Birth: __________________________________________________ COUNTRY MONTH / DAY / YEAR Phone: ________________________ Fax: __________________________ E-mail: ________________________________________________________ Have you previously been a member of ORS? What happened to previous membership? Degree(s): Yes No PhD _____ Year MS _____ Year BS _____ Year Honorary Degree(s) ________________________________________________________ MD _____ Year Other Training and Study __________________________________ Other _________________________________ ________________________________________________________ __________________________________________ ________________________________________________________ Please list your membership(s) in other societies: Present Position(s): ______________________________________ ________________________________________________________ ________________________________________________________ I am a (Please check one): PRIMARY Affiliation (Please check one): SECONDARY Specialization (Please check one): Clinician Academic Basic Science Biologist Industry Applied Science Bioengineer Government Clinical Other General & Administrative Turn page for REQUIREMENTS REQUIREMENTS (These must be met in order for your application to be considered): 1. Attendance at one or more prior ORS Annual Meetings Year: ____________________________________ 2. ORS Sponsors: Letters of recommendation. Two letters from ORS Active members are required. Letters must address the applicant’s scientific and non-scientific contribution to orthopaedic research and must be on a letterhead. Letters must be submitted to the ORS office either via postal mail or e-mail to ors@ors.org or fax 847-823-5772. Please use the lines below to indicate the ORS members who will write recommendation letters: 1. Name ____________________________________________________________________________________________ (PRINT FIRST AND LAST NAME) 2. Name ____________________________________________________________________________________________ (PRINT FIRST AND LAST NAME) It is the applicant’s responsibility to ask ORS members for recommendation letters. Please use the checklist below to be sure you have included all necessary materials before sending to the society office: The original application. I have contacted and asked two members of the society to write letters of recommendation. Letters should be forwarded directly to the ORS office. $245 (U.S. dollars) application fee must be enclosed or the application will be returned – $220 (U.S. dollars) of the fee will be applied to first year’s dues upon acceptance. A check made payable to ORS, in U.S. dollars, drawn on a U.S. bank is enclosed. Please bill my credit card (AMEX, Mastercard, or Visa ONLY). ________________________________________________________ __________________________________________ (NAME ON CARD) (SIGNATURE) ________________________________________________________ __________________________________________ (CREDIT CARD NUMBER) (EXPIRATION DATE) All completed applications should be forwarded to: ORS MEMBERSHIP COMMITTEE 6300 N. RIVER ROAD, SUITE 602 ROSEMONT, IL 60018 Applications for membership are accepted year round. The Membership Committee reviews applications quarterly: March 15, June 15, September 15, and December 15. Applicants are notified about the Membership Committee’s decision within 4–6 weeks of the review date. If you are planning to attend the ORS Annual Meeting, your completed membership application must be received in the ORS office by December 15 to obtain reduced meeting registration rate. Applications received between September 15 and December 15 will be reviewed and billed for the following calendar year. If approved, these applicants will be eligible to obtain the reduced meeting registration rate. Applications received after December 15 will be reviewed for acceptance following the Annual Meeting. Members shall pay annual dues of $220.00, payable in U.S. funds, upon request of the ORS. Affiliate membership dues include a subscription to the Journal of Orthopaedic Research, which is $125.00 of the annual dues. Dues notices are sent out to members each October and can be paid online at www.ors.org. If you have any questions, please contact the ORS office at 847-823-5770 or ors@ors.org. SCIENTIFIC SESSIONS 23 Daily Meeting Highlights Saturday, February. 4, 2012 Room 2002-2004 Saturday, February 4, 2012 Professional Advancement Series I 8:00 AM 9:30 AM Deciding what Journals to Publish in? Advantages and Disadvantages of Different Journals Workshop 1 Biomaterial Based Approaches Towards Minimally Invasive Treatment of IVD Degeneration 9:00 AM 6:00 PM 9:45 AM 10:45 AM Stem Cells and Progenitors Intervertebral Disc: Stem Cells & Cell Line Session 2 Session 3 Tendon and Ligament: Biology & Development Molecular Influences on Cartilage Biomechanics Workshop 3 Session 7 Session 8 Tendon and Ligament: Regeneration Cell and Molecular Biomechanics: Physical Effects Inflammation in Osteoarthritis and Immune-Medicated Arthritis Current Insights on the Regenerative Potential for the Periosteum: Molecular, Cellular and Endogenous Engineering Approaches Presented by the ORS Women’s Leadership Forum Experimental Osteoarthritis Models: Lubrication and Pain Poster Walking Tours Spotlight Session 11 Spine Spotlight Speaker: James C Iatridis, PhD, “Biomechanics and Mechanobiology of Intervertebtal Disc Injury and Repair” NIRA Presentations 1 Cartilage and Spine Spotlight Session 12 Spotlight Session 13 ACL Reconstruction Spotlight Speaker: Kurt P Spindler, MD, “ACL Outcomes: An Evidence-Based Medicine Approach” Non-Coding RNA and Postranscriptional Regulation in Osteoarthritis Spotlight Speaker: Gary Gibson, PhD, “Serum Non-Coding RNAs as Biomarkers for Osteoarthritis” NIRA Presentations 2 Soft Tissue NIRA Presentations 3 Cartilage Biology and Osteoarthritis Session 5 Cell and Molecular Biomechanics: Osteocytes Session 9 12:00 PM 1:30 PM 4:15 PM 6:00 PM Workshop 2 Session 4 View Posters & Visit Exhibitors 3:15 PM 4:15 PM Room 2020-2024 Personalized Fracture Risk Assessment and Treatment in Osteoporosis from Population-Based to Patient-Specific Medicine 12:00 PM 1:30 PM 1:30 PM 3:00 PM Room 2014-2018 Poster and Exhibit Hours Session 6 11:00 AM 12:00 PM Room 2006-2008 Registration Open Session 1 24 Room 2005-2011 7:00 AM 6:00 PM Session 10 Fracture Healing Quality Spotlight Session 14 Spotlight Session 15 Tissue Reactions to Wear Spotlight Speaker: Patricia A Campbell, PhD, “Understanding Wear, Wear Products and Local Tissue Reactions around Total Hip Protheses” Osteoporosis Spotlight Speaker: David B Burr, PhD, “Osteoporosis Treatments: So Many Choices - A Medical Success Story” NIRA Presentations 4 NIRA Presentations 5 Fracture Repair Poster & Exhibit Session (Authors Available at Posters to Answer Questions) Bone Room 2005 Room 2014 WORKSHOP #1 WORKSHOP #2 BIOMATERIAL BASED APPROACHES TOWARDS MINIMALLY INVASIVE TREATMENT OF IVD DEGENERATION PERSONALIZED FRACTURE RISK ASSESSMENT AND TREATMENT IN OSTEOPOROSIS: FROM POPULATIONBASED TO PATIENT-SPECIFIC MEDICINE Organizers: Wouter J Dhert, PhD and Laura Creemers, PhD Organizers: Keita Ito, MD and Ralph Müller, PhD The application of regenerative approaches, in particular the use of autologous cells in the treatment of intervertebral disc degeneration has gained attention over the past decades. However, these approaches entail several disadvantages, such as leakage of the injected materials and the infliction of damage to the annulus fibrosis. The purpose of this workshop is to give an overview on currently developed biomaterialbased strategies to overcome these setbacks and to discuss their applicability and requirements. Almost a third to a half of all women and 15 to 30% of all men will face an osteoporotic fracture in their lifetime. Currently, once such a fracture is sustained, many will die of related complications within 12 month and others will remain impaired. Hence, it is imperative to identify those not only suffering from osteoporosis but specifically those at risk of fracture and to plan a preventive treatment which will lower their risk for such fractures. Although useful for the diagnosis of osteoporosis, the assessment of bone mineral density (BMD) and the T-score (deviation from average youthful BMD) does not differentiate well patients who are at risk for fracture. The hurdles to development of an accurate and useful clinical tool are many. Currently, diagnosis focuses on bone strength, but only indirect measures of this quality are conducted and not at the sites of most importance, i.e. axial skeleton. The risk of fracture though is not only dependent on bone strength but also on many other factors associated with loading events, which are not often assessed. Although clinical assessment is patient-specific, the diagnostic work-up is not. Regardless of the actual risk profile of the patient, screening, diagnostic, and prognostic methods are largely based on the same technology. Furthermore, there is also little patient-specific tailoring of treatments. Even when the pharmacological treatment appears insufficient, we simply wait for the fracture and try our best to deal with it. Clearly, available technology is insufficient. This workshop will explore many of these issues and introduce new bioengineering technologies, which will improve clinical diagnosis and treatment planning of osteoporotic fractures of the axial skeleton in a patientspecific manner. Injectable Hydrogels for the Application of Cell-Based Regenerative Approaches in Intervertebral Disc Degeneration Mauro R Alini, PhD Biomaterial-Based Annulus Fibrosus Repair in Intervertebral Disc Degeneration Dirk Grijpma, PhD Biomaterials for siRNA Delivery Daniel G Anderson, PhD Saturday, February 4, 2012 WORKSHOPS Saturday, February 4, 2012 8:00 AM - 9:30 AM A Personalized, Integrative Approach to the Estimation of the Risk of Bone Fracture Marco Viceconti, MSc, PhD Patient-Specific Loading in the Proximal Femur and Thoracolumbar Spine William Taylor, PhD Patient-Specific Pharmacological and Interventional Treatment Planning Stephen Ferguson, PhD 25 WORKSHOPS / PROFESSIONAL ADVANCEMENT SERIES I Saturday, February 4, 2012 8:00 AM - 9:30 AM Saturday, February 4, 2012 Room 2024 Room 2002 WORKSHOP #3 PROFESSIONAL ADVANCEMENT SERIES I CURRENT INSIGHTS ON THE REGENERATIVE POTENTIAL OF THE PERIOSTEUM: MOLECULAR, CELLULAR & ENDOGENOUS ENGINEERING APPROACHES DECIDING WHAT JOURNAL TO PUBLISH IN? (Presented by the ORS Women’s Leadership Forum) Organizer: Melissa L Knothe Tate, PhD Elucidation of the periosteum and its regenerative potential has become a hot topic in orthopaedics, e.g. more than half of the 1600+ articles indexed in PubMed and appearing under the keywords “periosteum and regeneration” were written in the past 10-12 years! The proposed workshop aims to bring biomedical researchers up-to-date on the state of the art in the science of periosteum and its regenerative potential. Molecular, cellular and tissue scale approaches to elucidating the mechanisms underlying the periosteum’s regenerative potential will be reviewed and discussed in light of translational therapies and engineering solutions inspired by the periosteum’s remarkable regenerative capacity. An interactive panel discussion at the end of the workshop will highlight current hurdles to advancement and clinical translation of these insights as well as current controversies in the field. New Approaches Towards Understanding Skeletal Repair and Regeneration Xingping Zhang, PhD Comparative Regenerative Capacities of Periosteum and Bone Marrow in Bone Repair Celine Colnot, PhD Surgical and Engineering Approaches to Unleash the Regenerative Power of the Periosteum Melissa L Knothe Tate, PhD 26 Prominent editors of leading Journals representing various disciplines will share their perspectives on the decision making process of which journal to publish in. Do’s and don’ts of the submission process will be discussed. Also, a lecture will be dedicated to the topic of paper authorship. Speakers: John Antoniou, MD, PhD Farshid Guilak, PhD Joseph Buckwalter, MD Joseph Lane, MD 9:45 AM - 10:45 AM Session 1 Session 2 9:45 AMPaper No. 0001 Cellular Mechanical Biomarkers for Lineage-Specific, Stem Cell Enrichment Eric M Darling, Nicholas R Labriola, Rafael D Gonzalez-Cruz, Vera C Fonseca 9:45 AMPaper No. 0007 Flexor Digitorum Sublimis Tendon Development Depends on Muscle Translocation Alice Huang, Timothy Riordan, Shai Hershko, Norihiro Yumoto, Steve Burden, Elazar Zelzer, Ronen Schweitzer 9:55 AMPaper No. 0002 Engineering phenotypically stable bone-like tissue from human embryonic stem cells Darja Marolt, Ivan Marcos Campos, Sarindr Bhumiratana, Ana Koren, Petros Petridis, Warren L Grayson, Patrice F Spitalnik, Gordana Vunjak-Novakovic 9:55 AMPaper No. 0008 The Effect of Muscle Unloading on Tendon Structure and Function During Postnatal Development Andrea Schwartz, Justin H Lipner, David Zeltser, Stavros Thomopoulos Stem Cells and Progenitors Room # 2002 Moderators: Robert E Guldberg, PhD, Gordana Vunjak-Novakovic, PhD 10:05 AMPaper No. 0003 Combinatorial Effects of Sonic Hedgehog and Nell-1 Signaling in Osteogenic versus Adipogenic Differentiation of Human Adipose-Derived Stromal Cells Khoi M Le, Aaron W James, Janette Zara, Shen Pang, Asal Askarinam, Michael Chiang, Wei Yuan, David Stoker, Xinli Zhang, Kang Ting, Chia Soo 10:15 AMPaper No. 0004 Adipose Stem Cells Secrete Factors that Inhibit Cartilage Regeneration Christopher Lee, Olivia A Burnsed, Vineeth Raghuram, Zvi Schwartz, Barbara D Boyan 10:25 AMPaper No. 0005 To Die or Not to Die, Let Glucose Decide: Application to Human Mesenchymal Stem Cells Survival After Implantation Mickael Deschepper, Mathieu Manassero, Laurent emmanuel Monfoulet, Karim Oudina, Delphine Logeart-Avramoglou, Hervé Petite 10:35 AMPaper No. 0006 Activation of Notch Signaling by Jagged1 Adsorption to a Poly(βamino ester) Enhances Human MSC Osteogenesis Michael Dishowitz, Harini Sundararaghavan, Jason A Burdick, Kurt D Hankenson Tendon and Ligament: Biology & Development Room # 2005 Moderators: HongBin Lu, PhD and Anthony Ratcliffe, PhD Saturday, February 4, 2012 Saturday, February 4, 2012 10:05 AMPaper No. 0009 Mechanical Loading Effects on Elastogenic Gene Expression of Embryonic Tendon and Ligament Cells In Vitro Varies with Developmental Stage and Anatomical Location Jeffrey P Brown, Violet G Finley, Alexander B Henry, Catherine K Kuo 10:15 AMPaper No. 0010 Tendon Mechanical, Compositional and Structural Changes in Decorin and Biglycan Null and Heterozygous Mice LeAnn Dourte, Lydia Pathmanathan, Mark Buckley, Abbas Jawad, Renato Iozzo, David Birk, Louis J Soslowsky 10:25 AMPaper No. 0011 Moderate Exercise Improves Degenerative Tendons through Tendon Stem Cells Jianying Zhang, Sen Lin, James H Wang 10:35 AMPaper No. 0012 Periosteum progenitor cell sheet enhanced tendon-bone healing better than acellular collagen sheet for anterior cruciate ligament reconstruction Chih-Hwa Chen, Shu Wen Whu, Chih-Hsiang Chang, HsienTao Liu, Kun-Chung Wang, Chun-I Su, Chung-Ming Yu, Chak-Bor Wong, I-Chun Wang, Hsia-Wei Liu, Shi-Hui Chen, Ching-Lin Tsai, Ging-Ho Hsiue 27 Saturday, February 4, 2012 Saturday, February 4, 2012 Session 3 Session 4 9:45 AMPaper No. 0013 Nanomechanics of Murine Cartilage Reveals the Effects of Chondroadherin Knockouts Michael Batista, Alan J Grodzinsky, Christine Ortiz, Lin Han, Dick Heinegård 9:45 AMPaper No. 0019 Toll-like receptor-4 and IL-1β-mediated MMP13 induction can be antagonized by erythromycin Tomoya Uchimura, Tong Shi, Wieping Ren, Li Zeng Molecular Influences on Cartilage Biomechanics Room # 2006 Moderators: Farshid Guilak, PhD and Russell J Fernandes, PhD 9:55 AMPaper No. 0014 Alteration of In Vivo Chondrocyte Gene Expression by Increased Chronic Loading in the Rat Maria Roemhildt, Daria Pause, Kiley Anderson, Mack Gardner-Morse, Bruce Beynnon, Julie Dragon 10:05 AMPaper No. 0015 Accumulation of Exogenous Activated TGF-β in the Superficial Zone of Immature Bovine Articular Cartilage Michael Albro, Robert Nims, Alexander D Cigan, Yuen Ching B Chen, Clark T Hung, Gerard A Ateshian 10:15 AMPaper No. 0016 Actin and Vimentin Structures Contribute to Chondrocyte Stiffness as Measured by Atomic Force Microscopy Jeffrey C Lu, Craig Blanchette, Cindy Thomas, Nadeen Chahine, Jasper Yik, Gabriela Loots, Paul E Di Cesare, Dominik R Haudenschild 10:25 AMPaper No. 0017 Matrilin-1 Deficiency Weakens Cartilage Matrix and Predisposes Mouse Knee to Osteoarthritis after Destabilization Jack Cossman, Xin Li, Eric M Darling, Yupeng Chen, Yingjie Guan, Qian Chen 10:35 AMPaper No. 0018 Co-Localization of Type VI Collagen and Perlecan to Lower Modulus Regions of the Pericellular Matrix of Porcine Articular Cartilage Rebecca E Wilusz, Louis E DeFrate, Farshid Guilak 28 9:45 AM - 10:45 AM Inflammation in Osteoarthritis and Immune-Medicated Arthritis Room # 2014 Moderators: John Sandy, PhD and Steven R Goldring, PhD 9:55 AMPaper No. 0020 Toll Like Receptor-2 Prevents Cartilage Damage in Osteoarthritis Models That Display Synovial Activation Arjen Blom, Peter L van Lent, Shahla Abdollahi-Roodsaz, Peter M van der Kraan, Wim B van den Berg 10:05 AMPaper No. 0021 Activation of Complement System and Altered Lipid Metabolism in Knee Osteoarthritis Keiichi Kuroki, Bridget Garner, Aaron M Stoker, James L Cook 10:15 AMPaper No. 0022 The cdk9 inhibitor flavopiridol effectively suppresses the activation of primary inflammatory response genes in human articular chondrocytes Jasper Yik, Ratna Kumari, Blaine Christiansen, Paul Di Cesare, Dominik R Haudenschild 10:25 AMPaper No. 0023 Hyaluronan inhibit the LPS induced Cathepsin K Expression via CD44 in TIG-1 Human Fibroblasts Shinya Hirabara, Toshihisa Kojima, Nobunori Takahashi, Masahiro Hanabayashi, Kenya Terabe, Naoki Ishiguro 10:35 AMPaper No. 0024 Ganglioside GM3 Plays a Critical Role in Pathogenesis of Mice Collagen-induced Arthritis Yukinori Tsukuda, Tadashi Yamashita, Masashi Kanayama, Naoki Seito, Tsuyoshi Asano, Akio Minami, Norimasa Iwasaki Saturday, February 4, 2012 9:45 AM - 10:45 AM Cell and Molecular Biomechanics: Osteocytes Room # 2024 Moderators: Randall L Duncan, PhD and Damian Genetos, PhD 9:45 AMPaper No. 0025 Simultaneous Tracking of 3D Actin and Microtubule Strains in Individual MLO-Y4 Osteocytes under Oscillatory Flow Andrew D Baik, Elizabeth M Hillman, Cheng Dong, X. Edward Guo 9:55 AMPaper No. 0026 Unloading of mouse long bone causes widespread apoptosis of cortical osteocytes: spatial and temporal relationships to increased bone resorption Pamela Cabahug, Oran Kennedy, Damien Laudier, Robert J Majeska, Shikha G Khandelwal, Stefan Judex, MItch B Schaffler Saturday, February 4, 2012 Session 5 10:05 AMPaper No. 0027 Osteocytes exhibit multiple calcium oscillations in response to mechanical loading Saja Al-Dujaili, Chao Liu, Axel Guenther, Lidan You 10:15 AMPaper No. 0028 Calcium Oscillations in Osteocyte Network are Dependent on Phospholipase C-mediated Signaling Pathway PuiLeng Isabel Leong, Victor C Chiang, Da Jing, X. E Guo 10:25 AMPaper No. 0029 Role of Calcitonin Gene-Related Peptide in Functional Adaptation of the Skeleton Susannah J Sample, Caitlin Heaton, Zhengling Hao, Jason A Bleedorn, Molly Racette, Peter Muir 10:35 AMPaper No. 0030 Transcriptome Analysis Reveals Novel Inflammatory Response of Osteocytes to Fluid Flow Peter Govey, Jon Jacobs, Norman Karin, Henry Donahue 29 Saturday, February 4, 2012 Saturday, February 4, 2012 Session 6 Session 7 11:00 AMPaper No. 0031 Differentiation of Mouse Induced Pluripotent Stem Cells (iPSCs) into Nucleus Pulposus-Like Cells in vitro Liufang Jing, Nicolas Christoforou, Kam W Leong, Setton A Setton, Jun Chen 11:00 AMPaper No. 0037 Genetic Analysis Reveals Developmental Modularity of Flexor Digitorum Sublimis Tendons Alice Huang, Timothy Riordan, Brian Pryce, Spencer Watson, Veronique LeFebvre, Fanxin Long, Ronen Schweitzer 11:10 AMPaper No. 0032 Adipose-derived Stem Cells Expressing BMP-6, not BMP2, Effectively Promote Vertebral Defect Regeneration Dmitriy Sheyn, Olga Mizrahi, Wafa Tawackoli, Gadi Pelled, Nadav Kimelman-Bleich, Dan Gazit, Zulma Gazit 11:10 AMPaper No. 0038 α2β1 Integrin Mediates Electric Field-Induced Directed Ligament Fibroblast Migration via RhoA Yu-Chen Cheng, Cheng-Hsien Tsai, Pen-hsiu Grace Chao Intervertebral Disc: Stem Cells & Cell Line Room # 2002 Moderators: Rita Kandel, MD and Chitra L Dahia, PhD 11:20 AMPaper No. 0033 Effects of Hypoxia on Rabbit Mesenchymal Stem Cell Differentiation towards a Nucleus Pulposus-like Phenotype on a Nanofibrous Scaffold Ganjun Feng, Xiaobing Jin, Jiang Hu, Haiyun Ma, Melanie J Gupte, Hao Liu, Peter X Ma 11:30 AMPaper No. 0034 Discogenic Pre-Conditioning of human Mesenchymal Stem Cells in synthetic MMP-Degradable Poly-EthyleneGlycol (PEG) Hydrogels under Load and rhGDF-5 Benjamin Gantenbein, Stefan Guggisberg, Samantha C Chan, Lorin M Benneker, Sibylle Grad 11:40 AMPaper No. 0035 Hydrostatic pressure enhances notochordal cell phenotype and metabolic activity with increased proteoglycan accumulation Devina Purmessur, Clare Canal Guterl, Marisa C Cornejo, Rosalyn D Abbott, Samuel K Cho, Damien Laudier, James Iatridis 11:50 AMPaper No. 0036 Age Associated Variation in the Adult Human Nucleus Pulposus Cell Phenotype Francesca E Ludwinski, Kanna Gnanalingham, Stephen M Richardson, Anthony J Freemont, Judith Hoyland 30 11:00 AM - 12:00 PM Tendon and Ligament: Regeneration Room # 2005 Moderators: Albert Banes, PhD and Steven P Arnoczky, DVM 11:20 AMPaper No. 0039 Progenitors Recruited to Injured Tendons Are Possible Culprits of Chondroid Degeneration Shuji Asai, Kengo Shimono, Wei Tung, Maurizio Pacifici, Masahiro Iwamoto, Motomi Enomoto-Iwamoto 11:30 AMPaper No. 0040 Expression of Wnt Pathway Mediators in Metaplasic Tissue in Animal Model and Clinical Samples of Tendinopathy - Potential Effects of Wnts on the Erroneous Differentiation of Tendon-Derived Stem Cells (TDSCs) in the Pathogenesis Yuk Wa Lee, Pauline Po Yee Lui, Yin Mei Wong, X. Zhang, K. Dai, Kai Ming Chan 11:40 AMPaper No. 0041 Platelet-Rich Plasma (PRP)Exerts Anti-inflammatory Effects on Injured Tendons Jianying Zhang, James H Wang 11:50 AMPaper No. 0042 Rat Rotator Cuff Tendon-to-Bone Healing Properties are Adversely Affected by Hypercholesterolemia David P Beason, Jennica J Tucker, Lena Edelstein, Chang Soo Lee, Joseph A Abboud, Louis J Soslowsky 11:00 AM - 12:00 PM Session 8 Session 9 11:00 AMPaper No. 0043 Role of CITED2 in human rheumatoid arthritis: a potential mechanism underlying the benefits of exercise in RA treatment Daniel Leong, Robert J Majeska, Michael J Bronson, Mitchell B Schaffler, Luis Cardoso, Herb B Sun 11:00 AMPaper No. 0049 Biomimetic Boundary Lubricants of Articular Cartilage Kirk Samaroo, Mingchee Tan, Roberto Eguiluz, Delphine Gourdon, David Putnam, Lawrence Bonassar Cell and Molecular Biomechanics: Physical Effects Room # 2006 Moderators: Robert Sah, MD, PhD and Alesha B Castillo, PhD 11:10 AMPaper No. 0044 Differential Expression of Transcriptional Clusters and Recurring ERK1/2 Activation In Bone Cells Subjected to Rest-Inserted Dynamic Fluid Flow Ronald Y Kwon, Leah E Worton, Sundar Srinivasan, Ted S Gross 11:20 AMPaper No. 0045 Platen-Less Deformational Loading of Cell-Seeded Scaffolds for Cartilage Mechanobiology and Tissue Engineering Eric G Lima, Mary T Ye, Stefania K Samojlik, Aaron M Stoker, Shashank Sirsi, Mark A Borden, Clark T Hung 11:30 AMPaper No. 0046 Dynamic Tensile Stretch Promotes Lamin A/C Reorganization and Chromatin Condensation in Adult Stem Cells Su-Jin Heo, Tristan P Driscoll, Nandan L Nerurkar, Robert L Mauck 11:40 AMPaper No. 0047 The Effect of TGF-β and BMP Pathway Inhibition on Chondrocyte Mechanotransduction Chun Hua Zheng, David C Hall, Marc E Levenston 11:50 AMPaper No. 0048 Microarray Analysis of Human MSC in 3D Collagen Culture: 10% Uniaxial Cyclic Tensile Strain Upregulates Genes Associated with Differentiation of Bone Cell Lines in the Absence of Soluble Osteogenic Inductive Factors Adisri Charoenpanich, Michelle Wall, Charles Tucker, Danica Andrews, David Lalush, Elizabeth Loboa Experimental Osteoarthritis Models: Lubrication and Pain Room # 2014 Moderators: Peter C Amadio, PhD and Carl R Flannery, PhD 11:10 AMPaper No. 0050 Cartilage Boundary Lubricating Ability of Aldehyde Modified PRG4 Saleem Abubacker, Hyun O Ham, Phillip B Messersmith, Tannin A Schmidt 11:20 AMPaper No. 0051 Synovial Fluid Lubricant Properties are Transiently Deficient after Articular Cartilage Defect Repair with Fibrin Alone and with Mesenchymal Stem Cells Murray J Grissom, Michele M Temple-Wong, Matthew S Adams, Matthew Tom, Barbara L Schumacher, Laurie R Goodrich, Constance R Chu, Robert L Sah Saturday, February 4, 2012 Saturday, February 4, 2012 11:30 AMPaper No. 0052 The Chondroprotective Effect of a Single-Dose Lubricin Tribosupplementation Following ACL Transection and Strenuous Exercise in the Rat Khaled A Elsaid, Ling X Zhang, Kimberly A Waller, Braden Fleming, Gregory Jay 11:40 AMPaper No. 0053 Knockout of the Osmoreceptor Channel, TRPV4 Increases Knee Osteoarthritis in Diet-induced Obesity Christopher J O’Conor, Timothy M Griffin, Wolfgang Liedtke, Farshid Guilak 11:50 AMPaper No. 0054 Limb Idleness Index (LII): A Novel Measurement of Gait Adaptation to Pain in a Rat Model of Osteoarthritis Sai Chuen Fu, Yau Chuk Cheuk, Tsui Yu Mok, Wai Hang Cheng, Leung Kim Hung, Kai Ming Chan 31 Saturday, February 4, 2012 1:30 PM - 3:00 PM Saturday, February 4, 2012 Session 10 Spotlight Session 11 11:00 AMPaper No. 0055 Homozygous Deletion of the Sost Gene Results in Faster Union and Increased Hard Callus Formation Michelle M McDonald, Alyson Morse, Kathy Mikulec, Lauren Peacock, Ina Kramer, Michaela Kneissel, David G Little 1:30 PM – 2:00 PM Fracture Healing - Quality Room # 2024 Moderators: Celine I Colnot, PhD and Adam Shimer, MD 11:10 AMPaper No. 0056 Dickkopf 1 Antibody Treatment Enhanced Fracture Healing in Adult Rat Closed Femoral Fracture Model Chaoyang Li, Hong-Lin Tan, Edward Lee, Mauricio Barrero, Frank Asuncion, Min Liu, Pam Kurimoto, Mike Ominsky, William Richards, Huazhu Ke 11:20 AMPaper No. 0057 Combined Use of Low Intensity Pulsed Ultrasound (LIPUS) and rhBMP-2 Enhances Strength of Newly Formed Bone in a Critical Sized Segmental Defect in the Rat Siddhesh R Angle, Kotaro Sena, Dale R Sumner, Walter W Virkus, Amarjit S Virdi 11:30 AMPaper No. 0058 Low Intensity Pulsed Ultrasound (LIPUS) Accelerates Systemic Recruitment of Mesenchymal Stem Cells (MSCs) for Fracture Healing Wai Ching Chin, Kwok Sui Leung, Gang Li, Ling Qin, Wing Hoi Cheung 11:40 AMPaper No. 0059 The Effect of Limb Ischemia on BMP-2-mediated Segmental Bone Defect Repair Brent A Uhrig, Joel D Boerckel, Nick J Willett, Mon-Tzu A Li, Nathaniel Huebsch, Robert E Guldberg 11:50 AMPaper No. 0060 Reporters for Cartilage Lineage Progression in Fracture Healing David W Rowe, Yu Mori, Chikara Ushiku, Xi Jiang, Liping Wang, Douglas J Adams Spine Room # 2002 Moderators: Nadeen O Chahine, PhD and Koichi Masuda, MD Spotlight Speaker: James C Iatridis, PhD Biomechanics and Mechanobiology of Intervertebral Disc Injury and Repair 2:00 PMPaper No. 0061 Mechanical and Biochemical Consequences of Needle Puncture Injury in the Mouse Caudal Disc John T Martin, Elizabeth E Beattie, Deborah J Gorth, Lachlan J Smith, Dawn M Elliott 2:10 PMPaper No. 0062 Mechanical Overloading Induces Early Degenerative Processes in the Lumbar Intervertebral Disc Cornelis P Paul, Aernout A Zuiderbaan, Tom J Schoorl, B. Zandieh Doulabi, Albert J van der Veen, Theo H Smit, Marco T Helder, Barend J van Royen, Margriet G Mullender 2:20 PMPaper No. 0063 Post-spaceflight recovery of biomechanical properties in murine caudal intervertebral discs Jeannie F Bailey, Kevin K Cheng, Alan R Hargens, Koichi Masuda, Jeffrey C Lotz 2:30 PMPaper No. 0064 Interactive Effect of IL-1 and BMP-7 on Cytokines, Matrix Components and Gene Expression of Human Intervertebral Disc Cells: Implications of pH and Oxyen Tension on Biological Therapy Rajeswari Pichika, Tomonori Yamaguchi, Alex Taborek, Won C Bae, Robert L Sah, Koichi Masuda 2:40 PMPaper No. 0065 BMP-7 suppresses TNF-mediated induction of the aggrecanases ADAMTS4/5 through antagonized activity of the transcription factor NF-kB in the intervertebral discs cells ZIli Wang, S Tim Yoon, William C Hutton 2:50 PMPaper No. 0066 Intervertebral Disc MRI T2* Mapping Correlated with Kinematic Outcomes Arin Ellingson, Hitesh Mehta, Edward Santos, Jonathan Sembrano, David Polly, David Nuckley 32 1:30 PM - 3:00 PM Spotlight Session 12 Spotlight Session 13 1:30 PMPaper No. 0067 Tissue Engineered Bone-Ligament-Bone Constructs Following 9-Month Sheep ACL Reconstruction Jinjin Ma, Michael J Smietana, Edward M Wojtys, Lisa M Larkin, Ellen M Arruda 1:30 PM – 2:00 PM ACL Reconstruction Room # 2005 Moderators: David L Butler, PhD and Vincent Wang, PhD 1:40 PMPaper No. 0068 T2* Weighted MRI Derived Morphology and Signal Intensity to Determine Structural Properties of an ACL Reconstruction Graft in a Porcine Model Alison M Biercevicz, Daniel L Miranda, Martha M Murray, Jason Machan, Braden C Fleming 1:50 PMPaper No. 0069 Alendronate Reduced Peri-tunnel Bone Loss and Enhanced Tendon Graft to Bone Tunnel Healing in ACL Reconstruction Yuk Wa Lee, Pauline Po Yee Lui, Tsui Yu Mok, Yau Chuk Cheuk, Kai Ming Chan 2:00 PMPaper No. 0070 Genetically Engineered and Systemically Expressing Kusabira-Orange Transgenic Pigs as in vivo Model to Trace Cell Recruitment after Anterior Cruciate Ligament Reconstruction Hiroki Takeuchi, Hiroyuki Enomoto, Hiroshi Nagashima, Toshikazu Yoshikawa, Yasunori Okada, Hideo Matsumoto, Yoshiaki Toyama, Yasunori Suda 2:10 PMPaper No. 0071 The New Strategy for ACL Reconstruction Using ACL-derived CD34-positive Cell Sheet Yutaka Mifune, Tomoyuki Matsumoto, Satoshi Terada, Yuichi Hoshino, Arvydas Usas, Burhan Gharaibeh, Ryosuke Kuroda, Masahiro Kurosaka, Freddie H Fu, Johnny Huard 2:20 PMPaper No. 0072 ACL Reconstruction with Immediate Anatomic Reattachment of the Native ACL in an Ovine Model Results in Minimal Kinematic Differences and Greater Evidence of Early OA Compared with Sham Controls Etienne J O’Brien, Jillian E Beveridge, Kyla D Huebner, Bryan J Heard, Janet E Tapper, Nigel G Shrive, Cyril (Cy) B Frank 2:30 PM – 3:00 PM Spotlight Speaker: Kurt P Spindler, MD ACL Outcomes: An Evidence-Based Medicine Approach Non-Coding RNA and Posttranscriptional Regulation in OA Room # 2006 Moderators: Hui Bin Sun, PhD, and Christopher H Evans, PhD Spotlight Speaker: Gary Gibson, PhD Serum Non-Coding RNAs as Biomarkers for Osteoarthritis 2:00 PMPaper No. 0073 CpG Methylation-dependent Transcriptional Control of MMP13 and IL1B in Human Chondrocytes: HIF-2 alphadriven MMP13 Transactivation Depends Upon CpG Methylation Status Ko Hashimoto, Miguel Otero, Kei Imagawa, Maria C Andres, Helmtrud I Roach, Richard O Oreffo, Mary B Goldring Saturday, February 4, 2012 Saturday, February 4, 2012 2:10 PMPaper No. 0074 MicroRNA-23b and 27b regulate both Hypoxia-inducible factor-2α and endochondral ossification related gene expressions in osteoarthritic chondrocytes Shinya Ishizuka, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Yohei Ohno, Motoshige Nakashima, Tetsuya Matsukawa, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita, Naoki Ishiguro 2:20 PMPaper No. 0075 MicroRNA-125b Regulates the Expression of Aggrecanase-1 (ADAMTS4) in Human Osteoarthritic Chondrocytes Tetsuya Matsukawa, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Omachi, Yohei Ohno, Motoshige Nakashima, Shinya Ishizuka, Naoki Ishiguro, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita 2:30 PMPaper No. 0076 Transition of microRNA expression in peripheral mononuclear cell accorrding to the prognosis of osteoarthritis Atsushi Okuhara, Tomoyuki Nakasa, Hayatoshi Shibuya, Takuya Niimoto, Nobuo Adachi, Masataka Deie, Mitsuo Ochi 2:40 PMPaper No. 0077 Osteochondral repair using a novel biphasic implant made of scaffold-free tissue engineered construct derived from synovial mesenchymal stem cells and hydroxyapatite-based artificial bone Kazunori Shimomura, Yu Moriguchi, Wataru Ando, Ryosuke Nansai, Tomoya Susa, Kyuichiro Imade, Syouta Mochizuki, Hiromichi Fujie, Keisuke Kita, Tatsuo Mae, Ken Nakata, Konsei Shino, Hideki Yoshikawa, Norimasa Nakamura 2:50 PMPaper No. 0078 The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model Takeshi Shoji, Tomoyuki Nakasa, Shigeru Miyaki, Yuji Yasunaga, Mitsuo Ochi 33 Saturday, February 4, 2012 Saturday, February 4, 2012 Spotlight Session 14 Spotlight Session 15 1:30 PM – 2:00 PM 1:30 PMPaper No. 0085 The Role of Mesenchymal Stem Cell in Diabetic Osteoporosis Tsung-Lin Tsai, Wan-Ju Li, Albert Wang, Matthew Squire Tissue Reactions to Wear Room # 2014 Moderators: J. Mark Wilkinson, Phd and John H Currier, MS Spotlight Speaker: Patricia A Campbell, PhD Understanding Wear, Wear Products and Local Tissue Reactions Around Total Hip Prostheses 2:00 PMPaper No. 0079 Effect of Circulating Metal after Metal-on-Metal Hip Resurfacing on the Brain: An MRI Study Matthew Clark, Jennifer Prentice, Martyn N Paley, Nigel Hoggard, Ian Stockley, J. Mark Wilkinson 2:10 PMPaper No. 0080 The Risk of Edge Loading in the Current Generation of Metal-on-Metal Hip Resurfacings Richard J Underwood, Angelos Zografos, Ritchie S Sayles, Philippa Cann 2:20 PMPaper No. 0081 Retrieved MoM heads show damage from in vivo articulation and bearing contact John H Currier, Dermott J McHugh, Dana Tower, Daniel Barlow, John P Collier, Douglas W Van Citters 2:30 PMPaper No. 0082 Metal Ion Levels After Revision Of Large Head Metal-onMetal Hip Replacements With Abnormal Wear Karren Takamura, Raghavendra Sidaginamale, Jamshid Gandhi, Antoni V Nargol, David Langton 2:40 PMPaper No. 0083 A Randomized Trial Comparing Metal Ions after Total Hip Arthroplasty with a Large Head Metal-on-Metal vs. Metal-on-Polyethylene Bearing Paul Beaulé, Luke Gauthier, Paul Kim, Robert Feibel, Peter Thurston, Laurent Dinh 2:50 PMPaper No. 0084 Guidance for interpreting metal ion concentrations in order to detect abnormal wear of metal-on-metal hip resurfacings Karren Takamura, Tom Joyce, James Lord, Andrew Taylor, Antoni V Nargol, David Langton 34 1:30 PM - 3:00 PM Osteoporosis Room # -2024 Moderators: Joseph M Lane, MD and Gloria Gronowicz, PhD 1:40 PMPaper No. 0086 GDC-0941 is Sufficient to Prevent Unloading Induced Bone Loss in the Femoral Head of a NF1 Murine Model Ping Zhang, Shi Chen, Steven Rhodes, Yongzheng He, Pei Zhang, Xianlin Yang, Jin Yuan, Xiaohong Li, Li Jiang, FengChun Yang 1:50 PMPaper No. 0087 Combined Effects of Glucocorticoids and TNF-α on Murine Trabecular Bone Quality Jason A Inzana, Masahiko Takahata, Subhash Juneja, Edward M Schwarz, Hani A Awad 2:00 PMPaper No. 0088 Targeted disruption of heparan sulfate in osteoblasts leads to severe osteoporotic phenotype in mice Satoshi Nozawa, Fumitoshi Irie, Shinji Iizuka, Thomas L Clements, Kazu Matsumoto, Yu Yamaguchi 2:10 PMPaper No. 0089 Alendronate Treatment Elicits a Reduction in Fatigue-Life of Canine Cortical Bone Joseph R Geissler, Devendra Bajaj, Matthew R Allen, David B Burr, James C Fritton 2:20 PMPaper No. 0090 Non-Specific Cathepsin B Inhibitor CA-074Me Inhibits Osteoclastogenesis via c-FOS Upregulation Blockade Neel Patel, Francis Y Lee 2:30 PM – 3:00 PM Spotlight Speaker: David B Burr, PhD Osteoporosis Treatments: So Many Choices - A Medical Success Story 1:30 PM - 3:00 PM New Investigator Recognition Award Presentations 1 New Investigator Recognition Award Presentations 2 3:15 PM Paper No. 0325 Human CD133 positive cells with a magnetic delivery system promote functional recovery in rat spinal cord injury Yuki Fujioka, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Toshio Nakamae, Bunichiro Izumi, Ryo Ohta 3:15 PMPaper No. 0332 Finite Element Analysis of Median Nerve Stresses in Carpal Tunnel Syndrome Patients and Matched Normals Jessica E Goetz, Thomas E Baer, Daniel R Thedens, Ericka A Lawler, Thomas Brown Spine Room # 2002 Moderators: Michael M Morlock, PhD and Theo Smit, PhD 3:23 PMPaper No. 0326 Elevated Lysyl hydroxylase 2b expression during experimental OA; the potential cause of persistent synovial fibrosis Dennis Remst, Esmeralda Blaney Davidson, Elly L Vitters, Ruud A Bank, Wim B van den Berg, Peter M van der Kraan 3:31 PMPaper No. 0327 Analysis of the Proliferative Response of Fibroblasts Obtained From Arthrofibrotic Tissue Chaoxu Liu, Roland Meister, Carl Haasper, Christian Krettek, Michael Jagodzinski 3:39 PMPaper No. 0328 A Critical Role of Parathyroid Hormone Type 1 Receptor in Postnatal Growth and Maintenance of Intervertebral Disc Fanjie Zeng, Mu Xiao, Ming Xue, Xinping Zhang 3:47 PMPaper No. 0329 Direct Cartilage Repair Using 3D Bioprinting Technology Xiaofeng Cui, Kurt Breitenkamp, M.G. Finn, Martin Lotz, Darryl D’Lima 3:55 PMPaper No. 0330 The Viscoelastic Recovery of Chondrocytes In Situ after Static and Dynamic Compressions Sang Kuy Han, Ryan Madden, Walter Herzog 4:03 PMPaper No. 0331 Signal Heterogeneity on Cartilage T2 Maps Predict Rapid Symptomatic Progression of OA Kenneth Urish, Matthew Keffalas, John Durkin, David Miller, Constance Chu, Timothy Mosher Soft Tissue Room # 2005 Moderators: James H Wang, PhD and Stavros Thomopoulos, PhD 3:23 PMPaper No. 0333 Acceleration of Tendon-Bone Healing of Anterior Cruciate Ligament Graft Using Autologous Ruptured Tissue Tomoyuki Matsumoto, Seiji Kubo, Ken Sasaki, Yohei Kawakami, Shinya Oka, Koji Takayama, Hiroshi Sasaki, Katsumasa Tei, Takeshi Ueha, Takehiko Matsushita, Yutaka Mifune, Masahiro Kurosaka, Ryosuke Kuroda Saturday, February 4, 2012 Saturday, February 4, 2012 3:31 PMPaper No. 0334 Development of siRNA Technology to Prevent Scarring and Adhesion Formation after Tendon Repair Sirish K Kondabolu, Kiminori Yukata, Shanshan Shi, Jennifer Jonason, TianFang Li, Hani A Awad, Regis J O’Keefe 3:39 PMPaper No. 0335 Cellular and molecular interactions in flexor tendon repairs: Towards regenerative scarless healing Subhash C Juneja, Regis J O’Keefe, Edward M Schwarz, Hani A Awad 3:47 PMPaper No. 0336 In Vivo ACL Length Change During High Demanding Activity Yuichi Hoshino, Gele Moloney, Freddie H Fu, Scott Tashman 3:55 PMPaper No. 0337 PTHrP Regulates the Modeling of Entheses During Linear Growth Meina Wang, Joshua VanHouten, Randy L Johnson, Guoying Liang, Arthur E Broadus 4:03 PMPaper No. 0338 The Role of Cellular Retinol Binding Protein 1 (CRBP1) in Regulating Function of Mesenchymal Stem Cells Liangliang Xu, Fanbiao Meng, Gang Li 35 Saturday, February 4, 2012 Saturday, February 4, 2012 New Investigator Recognition Award Presentations 3 New Investigator Recognition Award Presentations 4 3:15 PMPaper No. 0339 Regulation of Cartilage Homeostasis Genes by Matrilin-3: Dependency on Interleukin-1 Receptor Antagonist Chathuraka T Jayasuriya, Mary B Goldring, Richard M Terek, Qian Chen 3:15 PMPaper No. 0346 Cartilage Grafts: An improved mechanism to promote bone regeneration? Chelsea S Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio 3:23 PMPaper No. 0340 Mmp13 is A Critical Target Gene during the Development of Osteoarthritis Jie Shen, Meina Wang, Hongting Jin, Erik Sampson, Hee-Jeong Im, Di Chen 3:23 PMPaper No. 0347 Erythropoietin improves bone repair in atrophic non-unions Joerg H Holstein, Marcel Orth, Claudia Scheuer, Andrea Tami, Patric Garcia, Tina Histing, Tim Pohlemann, Michael D Menger Cartilage Biology and Osteoarthritis Room # 2006 Moderators: Warren Knudson, PhD and Hicham Drissi, PhD 3:31 PMPaper No. 0341 Transcription Factor Erg Is Required for Long-term Articular Cartilage Maintenance Yoichi Ohta, Takahiro Okabe, Shuji Asai, Agnese Di Rocco, Colleen Larmour, Motomi Enomoto-Iwamoto, Maurizio Pacifici, Masahiro Iwamoto 3:39 PMPaper No. 0342 A selective c-Fos/AP-1 inhibitor prevents cartilage destruction in a mouse model of osteoarthritis Hiraku Motomura, Yoshito Matsui, Shoji Seki, Shunichi Shiozawa, Tomoatsu Kimura 3:47 PMPaper No. 0343 Annexin A6 Accelerates Osteoarthritis Progression by Stimulating NF-κB Activity Kirk Campbell, Takeshi Minashima, Scott Hadley, Martin Quirno, You Jin Lee, Thorsten Kirsch 3:55 PMPaper No. 0344 Reduced Expression of Collagen type IX in Human Osteoarthritic Chondrocytes is Associated with Epigenetic Silencing by DNA Hypermethylation Kei Imagawa, Maria C de Andrés, Ko Hashimoto, Eiji Itoi, Mary B Goldring, Richard O Oreffo 4:03 PMPaper No. 0345 Exosomes function in a novel communication pathway among joint tissue cells in OA pathogenesis Tsuyoshi Takada, Shigeru Miyaki, Yoshihiro Nakamura, Tomohiro Kato, Tomoyuki Nakasa, Yoshio Kato, Martin K Lotz, Mitsuo Ochi 36 3:15 PM - 4:15 PM Fracture Reapair Room # 2014 Moderators: George L Barnes, and TBD 3:31 PMPaper No. 0348 T-Lymphocytes Enable Osteoblast Maturation During Early Phases of Fracture Repair Diane Nam, Elaine Mau, Yufa Wang, David Silkstone, Cari Whyne, Benjamin Alman 3:39 PMPaper No. 0349 Intermittent Teriparatide (hPTH 1-34) Treatment Rescues an Impaired Fracture Healing in COX-2 Mutant Mice Kiminori Yukata, Chao Xie, Tian-Fang Li, Jennifer Jonason, Xinping Zhang, Hani A Awad, Edward M Schwarz, Regis J O’Keefe 3:47 PMPaper No. 0350 Anti-Dkk1 Antibody Promotes Bone Fracture Healing through Activation of β-Catenin Signaling Hongting Jin, Meng Mi, Matthew Hilton, Hee-Jeong Im, HuaZhu Ke, Philip Babij, Di Chen 3:55 PMPaper No. 0351 Suicide Gene Therapy Approach with a Dual Expression LV Vector Enhances the Safety of Ex Vivo Gene Therapy for Bone Repair Farhang Alaee, Osamu Sugiyama, Mandeep Virk, Amy Tang, Alex Lichtler, Jay Lieberman 4:03 PMPaper No. 0352 Intravital Imaging Mesenchymal Stem Cell-Mediated Skeletal Repair in vivo Chunlan Huang, Vincent Ness, Edward Brown, Xinping Zhang Saturday, February 4, 2012 3:15 PM - 4:15 PM Bone Room # 2024 Moderators: Clifford M Les, DVM, PhD and TBD 3:15 PMPaper No. 0353 The Effect of Wnt on Bone Marrow Transplant in a Critical Size Calvarial Defect Jie Jiang, Stefanie D Monica, Johnathan J Urena, Andrew Liao, Jill A Helms 3:23 PMPaper No. 0354 Role of donor and host cyclooxygenase-2 in muscle derived stem cell mediated bone healing in critical sized calvarial defect model Xueqin Gao, Arvydas Usas, Aiping Lu, Ying Tang, Minakshi Poddar, Jessica C Tebbets, Mathieu Huard, James H Cummins, Johnny Huard Saturday, February 4, 2012 New Investigator Recognition Award Presentations 5 3:31 PMPaper No. 0355 Specific Biomimetic Hydroxyapatite Nanotopographies Enhance Bone Isograft Osteointegration Alayna Loiselle, Lai Wei, Gregory Lewis, Emmanuel Paul, Akhlesh Lakhtakia, Henry Donahue 3:39 PMPaper No. 0356 In Vivo Evaluation of Biochemically and Mechanically Guided Implant Osseointegration Jason P Long, Steven A Goldstein 3:47 PMPaper No. 0357 Low Intensity Vibrations Attenuate the Age-Related Bone Loss and Immune System Damage Induced by Obesity Meilin E Chan, Kim Kawatra, Michelle Cheung, Danielle Green, Ben Adler, Ada H Tsoi, Mario E Botros, Clinton T Rubin 3:55 PMPaper No. 0358 A Mechanosensory Role for the Primary Cilium in Human Mesenchymal Stem Cells David A Hoey, Shane J Tormey, Fergal J O’Brien, Christopher R Jacobs 4:03 PMPaper No. 0359 Evaluation of Spatial Variation in Tissue-level Mechanical Properties of Small Animal Cortical Bone under Diametral Compression Devendra Bajaj, Rohit Belman, James C Fritton 37 Daily Meeting Highlights Sunday, February 5, 2012 Room 2002 Sunday, February 5, 2012 Room 2006 Room 2014 6:30 AM 7:30 AM RIG: An Update on Research Topics and Future Directions in Intervertebral Disc Research RIG: Growth Factors 7:00 AM 6:00 PM Registration Open Professional Advancement Series II 8:00 AM 9:30 AM Optimizing Skills for a Successful Research Career Organized by the ORS Membership, New Investigators Mentoring, Special Projects Committees, and the ORS Women’s Leadership Forum Room 2005 Workshop 4 Workshop 5 Workshop 6 Workshop 7 New Insights into the Effects of Spaceflight in Musculoskeletal Tissues Organizers: Jamie Fitzgerald, PhD and Stavros Thomopoulos, PhD Bone Infection: An Unresolved Problem Organizer: Geoff Richards, PhD CT and MRI Metal Artifact Reduction Update - Relevance in Orthopaedic Research Organizers: Douglas D Robertson, MD, PhD and Gulshan B Sharma, PhD Translational Animal Models in Orthopaedic Research Organizers: Laurie R Goodrich, DVM and Kurt D Hankenson, DVM, PhD Session 19 Session 20 8:00 AM 4:30 PM 9:45 AM 10:45 AM 11:00 AM 12:00 PM Poster and Exhibit Hours Session 16 Intervertebral Disc Session 21 Bone and Spine Biomechanics 12:00 PM 1:30 PM 1:30 PM 3:00 PM 38 Room 2024 Session 17 Session 18 ACL Injury Mechanics Cartilage and Meniscus Repair Session 22 Cell Signaling Session 23 Tendon Biomechanics Bone Mechanics Session 24 Bone - Aging Session 25 Cartilage Degradation Fracture Healing Biomarkers and Imaging Modulation Poster & Exhibit Session (Authors Available at Posters to Answer Questions) Spotlight Session 26 Spotlight Session 27 Current Trends in Joint Replacement Spotlight Speaker: Steve M Kurtz, PhD, “Current Trends and Projected Utilization of Total Joint Replacements” Tendon and Ligament: Translational Research Spotlight Speaker: Scott A Rodeo, MD, “A Clinician-Scientist’s View on Translation of Tendon and Ligament Research to Clinical Care” Spotlight Session 28 microRNA Spotlight Speaker: Jane B Lian, PhD, “mircoRNAs Control the Skeletal Landscape” Spotlight Session 29 Regenerative Approaches to Osteoarthritis Spotlight Speaker: Farshid Guilak, PhD, “Stem Cells and Tissue Engineering to Treat Osteoarthritis” 3:00 PM 4:30 PM View Posters & Visit Exhibits 3:00 PM 4:30 PM Poster Walking Tours 4:30 PM 5:00 PM Poster Session 1 Removal of Posters 5:00 PM 5:30 PM Poster Session 2 Set Up Posters Spotlight Session 30 Muscle/Bone Spotlight Speaker: Lynda F Bonewald, PhD, “Bone and Muscle Interactions Independent of Loading” RESEARCH INTEREST GROUPS (RIGs) Sunday, February 5, 2012 6:30 AM - 7:30 AM Room 2006 AN UPDATE ON RESEARCH TOPICS AND FUTURE DIRECTIONS IN INTERVERTEBRAL DISC RESEARCH Room 2014 GROWTH FACTORS Organizer: Stephen Trippel, PhD WORKSHOPS Sunday, February 5, 2012 8:00 AM - 9:30 AM Room 2005 Room 2006 WORKSHOP 4 WORKSHOP 5 NEW INSIGHTS INTO THE EFFECTS OF SPACEFLIGHT IN MUSCULOSKELETAL TISSUES BONE INFECTION: AN UNRESOLVED PROBLEM Organizers: Jamie Fitzgerald, PhD and Stavros Thomopoulos, PhD The response of skeletal tissues to microgravity is poorly understood. While it is recognized that bone mineral density decreases and muscles atrophy in spaceflight, very little is known about the molecular underpinnings of these effects. In addition, virtually nothing is known about the effects of microgravity on other musculoskeletal tissues such as cartilage and tendon. The speakers in this workshop all participated in a NASA mouse tissue Biospecimen Sharing Program on two Space Shuttle flights in 2010 and 2011. The purpose of this workshop is to educate the audience about the latest insights into the effects of spaceflight on bone and muscle and two previously under-investigated tissues: cartilage and tendon. The application of new cellular and molecular techniques to the analysis of these tissues provide new insights into the effects of microgravity on musculoskeletal tissues. Activation of Stress Response Networks in Cartilage and Skeletal Muscle During Spaceflight Jamie Fitzgerald, PhD The Effects of Microgravity on the Rotator Cuff of the Shoulder Stavros Thomopoulos, PhD Sunday, February 5, 2012 Organizers: Fackson Mwale, PhD; Daisuke Sakai, MD, PhD; Sibylle Grad, PhD; Makarand Risbud, PhD, Rita Kandel, MD, and Peter J Roughley Organizer: Geoff Richards, PhD Musculoskeletal Infection continues to be a challenge in orthopedic and trauma surgery with immense socioeconomic impact. Despite significant advances in research and development and best medical and surgical practices, bone and bone associated infections are still difficult to diagnose, impossible to prevent in all cases and definitive treatment requires surgical removal of the implant. The most pressing issues in this field involve the requirement for sensitive and specific infection diagnostics and improved antimicrobial intervention strategies. It is the purpose of this workshop to present the latest advances in the diagnosis and treatment of musculoskeletal infections and describe the state of the art in animal models required for the development of these urgently required solutions. Improved Diagnostics for Musculoskeletal Infections Mark E Shirtliff, PhD Tethered Antibiotics: A New Paradigm for Implant Design Noreen J Hickok, PhD Animal Models of Orthopedic Infection Fintan Moriarty, PhD Altered Biomechanics of Mouse Intervertebral Discs Following 15 Days of Microgravity Jeffrey C Lotz, PhD Bone Loss in Microgravity is Associated with Activation of Specific Intracellular Signaling Pathways Eduardo Almeida, PhD 39 WORKSHOPS Sunday, February 5, 2012 8:00 AM - 9:30 AM Sunday, February 5, 2012 Room 2014 Room 2024 WORKSHOP 6 WORKSHOP 7 CT AND MRI METAL ARTIFACT REDUCTION UPDATE: RELEVANCE TO ORTHOPAEDIC RESEARCH TRANSLATIONAL ANIMAL MODELS IN ORTHOPAEDIC RESEARCH Organizers: Douglas D Robertson, MD, PhD and Gulshan B Sharma, PhD Organizers: Laurie R Goodrich, DVM and Kurt D Hankenson, DVM, PhD Obtaining structural information of bone and soft tissue adjacent to orthopaedic hardware is critical not only for research but for diagnosing orthopaedic derangement, preoperatively planning, and assessing outcomes. To date, radiography is the principal method for obtaining this information. While CT and MRI have revolutionized orthopaedic research and diagnosis, metal artifact has limited their full potential. The reduction of metal artifact will permit morphological and densitometric assessments adjacent to hardware assisting researchers throughout the field of orthopaedics. New methods are available which significantly improve CT and MR imaging adjacent to orthopaedic hardware. Translational research, the transfer of basic science discoveries to human clinical problems, relies heavily on comparative animal models of injury and dysfunction. However, in choosing an animal model, significant consideration must be given to species, model-type (surgical, mechanical, or pharmacological vs. naturally occurring), and how closely those models mimic human disorders. Thus, a nuanced understanding of species differences in anatomy, physiology, pathology, and treatment is required. With these considerations, veterinarians, who are trained with a highly comparative educational pedagogy, contribute significantly to the advancement of orthopaedic research through the development of animal models of musculoskeletal dysfunction. This workshop will highlight the contribution that veterinarians make to orthopaedic research through animal model development, selection, and analysis. Issues pertaining to model selection criteria and analysis will be described. The development of non-rodent models of bone, cartilage, ligament and meniscus will be discussed. Post-operative monitoring and associated animal care and use issues will be considered. As well, each speaker will bring a unique perspective - the models will be viewed through the eyes of a large animal surgeon, a small animal surgeon, and a veterinary pathologist. New CT Metal Artifact Reduction Techniques for Orthopaedic Hardware Yiannis Kyriakou, PhD New MR Imaging Methods for Metal Orthopaedic Hardware Brian Hargreaves, PhD The Horse as a Model of Naturally Occurring Osteoarthritis C Wayne McIlwraith, DVM, PhD Bone Loss in Primates: A Preclinical Model for Osteoporosis Christopher Jerome, PhD The Dog as a Translational Model for Othopaedic Disorders James L Cook, DVM, PhD 40 Professional Advancement Series II Sunday, February 5, 2012 8:00 AM - 9:30 AM Room 2002 PROFESSIONAL ADVANCEMENT SERIES II This interactive session will provide you with practical ideas to effectively communicate key messages about your research to non-academic audiences including the media; assist you in finding ways to seek research funding when the initial request may not be granted. Finally, recent recalls in the orthopaedic industry has called into question how new innovations should be introduced into clinical practice. Speakers: John Antoniou, MD, PhD Annie C Hayashi, MA James C Iatridis, PhD Mohit Bhandari, MD Sunday, February 5, 2012 OPTIMIZING SKILLS FOR A SUCCESSFUL RESEARCH CAREER 41 Sunday, February 5, 2012 Session 16 Session 17 9:45 AMPaper No. 0091 SIRT1 activates cell proliferation activity of human intervertebral disc both in low nutritional and chemical hypoxic conditions Zhongying Zhang, Kenichiro Kakutani, Koichiro Maeno, Takuto Kurakawa, Hiroaki Hirata, Junya Yamamoto, Takashi Yurube, Toru Takada, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida 9:45 AMPaper No. 0097 Muscle coordination during single-leg landing: Implications for ACL injuries Hossein Mokhtarzadeh, Tomas A Correa, Chen Hua Yeow, Denny Oetomo, James C Goh, Peter V Lee Intervertebral Disc Room # 2002 Moderators: Gunnar B Andersson, MD, PhD and Mauro R Alini, PhD Sunday, February 5, 2012 9:55 AMPaper No. 0092 Alterations in Intervertebral Disc with Mucopolysaccharidosis VI Disorder Alon Lai, Calogera Simonaro, Edward Schuchman, Damien Laudier, James Iatridis 10:05 AMPaper No. 0093 High fat diet induces disc degeneration in mouse: a preliminary study Xinlin Yang, Daidong Wang, Yasir Akhtar, Zhen Yan, Xudong Li 10:15 AMPaper No. 0094 Prolonged microgravity degenerates biomechanical properties of the murine caudal intervertebral discs Jeannie F Bailey, Kevin K Cheng, Alan R Hargens, Koichi Masuda, Jeffrey C Lotz 10:25 AMPaper No. 0095 Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes: MRI T2-mapping and histological study Takao Imanishi, Koji Akeda, Shuji Obata, Takahiro Iino, Tomomi Yamada, Akihiro Sudo 10:35 AMPaper No. 0096 Comparison of Biomechanical Behavior, Morphology, and Disc Health Between Double-Layer and Single-Layer Endplates Aaron J Fields, Francisco Sahli, Azucena G Rodriguez, Jorge Ramos, Tony M Keaveny, Jeffrey C Lotz 42 9:45 AM - 10:45 AM ACL Injury Mechanics Room # 2005 Moderators: John J Elias, PhD and Lynn Snyder-Mackler, PT 9:45 AMPaper No. 0098 Modification of In Vivo ACL Strain Patterns during Jump Landing Through Verbal Instruction Daniel W Brown, Kevin A Taylor, Gangadhar M Utturkar, Charles E Spritzer, Robin M Queen, William E Garrett, Louis E DeFrate 9:55 AMPaper No. 0099 Effect of Lateral Tibial Slope, Frontal Plane Alignment and Medial Tibial Concavity on ACL Strain During a Simulated Jump Landing Youkeun K Oh, Edward M Wojtys, James A Ashton-Miller 10:05 AMPaper No. 0100 The Geometry of the Articular Cartilage of the Tibial Plateau and Anterior Cruciate Ligament Injury Risk Aaron Scheinman, Bruce Beynnon, Helen C Smith, Daniel Sturnick, Pamela Vacek, Leigh Ann Holterman, Mack Gardner-Morse, Timothy Tourville, James Slauterbeck, Ira Bernstein, Sandra Shultz, Javad Hashemi, Robert Johnson 10:15 AMPaper No. 0101 Finite Element Model of the Knee for Investigation of High Rate Injury Mechanisms: Development and Validation Ali Kiapour, Ata Kiapour, Vikas Kaul, Carmen E Quatman, Richard C Ditto, Jason W Levine, Sam Wordeman, Timothy E Hewett, Constantine K Demetropoulos, Vijay K Goel 10:25 AMPaper No. 0102 Neuromuscular Control Not Quadriceps Size Differentiates Potential Copers from Non-Copers after ACL Injury Toran D MacLeod, Lynn Snyder-Mackler, Michael J Axe, Thomas S Buchanan 9:45 AM - 10:45 AM Session 18 Session 19 9:45 AMPaper No. 0103 Xenografts of Human Mesenchymal Stromal Cells (MSCs) Improve Repair of Rat Meniscus by Being Activated to Express Indian Hedgehog that Enhances Expression of Rat Type II Collagen Masafumi Horie, Hosoon Choi, Ichiro Sekiya, Takeshi Muneta, Darwin J Prockop 9:45 AMPaper No. 0109 Differential Nesprin Expression with Mesenchymal Stem Cell Fibrochondrogenesis and Altered Contractility Tristan P Driscoll, Michael T Yang, Su-Jin Heo, Ryan H Nakasone, Christopher S Chen, Robert L Mauck Cartilage and Meniscus Repair Room # 2006 Moderators: Francisco Forriol, MD, PhD and Carla R Scanzello, MD PhD 9:55 AMPaper No. 0104 BMP-7 treated Achilles tendon transplantation for meniscal defect in a rat model Nobutake Ozeki, Ichiro Sekiya, Koji Otabe, Hiroki Katagiri, Makiko Okuno, Kunikazu Tsuji, Tomoyuki Saito, Takeshi Muneta 10:05 AMPaper No. 0105 Overexpression of human TGF-β via rAAV gene transfer promotes the healing of human meniscal lesions in situ Magali Cucchiarini, Gertrud Schmitt, Myriam Ekici, Katharina Schmidt, Dieter Kohn, Henning Madry 10:15 AMPaper No. 0106 Increased Porosity and Early Cellularization Improves Integration of Nanofibrous Scaffolds to Native Meniscus Lara Ionescu, Robert L Mauck 10:25 AMPaper No. 0107 OA chondrons outperform OA chondrocytes: possible future application in OA cartilage repair? Miriam Rothdiener, Tino Felka, Qiong Wang, Tatiana UynukOol, Gunnar Ochs, Peter De Zwart, Atesch Ateschrang, Wilhelm Loewe, Dirk Albrecht, Andreas Badke, Ulrich Stoeckle, Alan J Grodzinsky, Wilhelm K Aicher, Bernd Rolauffs 10:35 AMPaper No. 0108 The Growth Factor Nell-1 Promotes Cartilage Regeneration in a Rabbit In Vivo Model Ronald K Siu, Janette Zara, Yaping Hou, Jinny Kwak, Xinli Zhang, Aaron W James, Alan Nguyen, Benjamin M Wu, Kang Ting, Chia Soo, Min Lee Cell Signaling Room # 2014 Moderators: Mary B Goldring, PhD and Karen A Hasty, PhD 9:55 AMPaper No. 0110 The Critical Role of the Epidermal Growth Factor Receptor in Endochondral Ossification Ling Qin, Xianrong Zhang, Valerie Siclari, Shenghui Lan, Ji Zhu, Eiki Koyama, Holly Dupuis, Frank Beier 10:05 AMPaper No. 0111 Activation of Wnt Planar Cell Polarity (PCP) pathway promotes growth plate column formation in vitro Rachel Randall, Yvonne Shao, Lai Wang, Tracy Ballock 10:15 AMPaper No. 0112 Synovial Wnt and WISP1 induce OA-like cartilage damage by skewing of TGF-beta signaling from Smad 2/3 towards Smad 1/5/8 phosphorylation Martijn H van den Bosch, Arjen B Blom, Peter L van Lent, Henk M van Beuningen, Fons A van de Loo, Esmeralda N Blaney Davidson, Peter M van der Kraan, Wim B van den Berg Sunday, February 5, 2012 Sunday, February 5, 2012 10:25 AMPaper No. 0113 Substrate Stiffness Promotes Chondrocyte Differentiation through Coordinated Activation of the TGFbeta Pathway Jessica Allen, Margaret Cooke, Tamara Alliston 10:35 AMPaper No. 0114 Tissue Microarray Analysis of Osteoartritic Samples Indicate Subchondral Trabecular Bone Changes Define Molecular Pathology Amy Opest, Theresa A Freeman 43 Sunday, February 5, 2012 Session 20 Session 21 9:45 AMPaper No. 0115 Effects of Age on Regulation of Human Osteoclast Differentiation Julie Glowacki, Ping-Lin Chung, Regina O’Sullivan, Behnam Eslami, Shuanhu Zhou, Longxiang Shen, Meryl S LeBoff 11:00 AMPaper No. 0121 High Prevalence of Sarcopenia and Decreased Muscle Mass in Patients with Osteoporotic Vertebral Fracture Tetsuro Hida, Naoki Ishiguro, Yoshihito Sakai, Yasumoto Matsui, Marie Takemura, Yasuto Terabe, Hiroshi Shimokata, Atsushi Harada Bone - Aging Room # 2024 Moderators: Peter Muir, PhD and Susan V Bukata, MD Sunday, February 5, 2012 9:55 AMPaper No. 0116 Non-Collagenous Matrix Proteins and Post-Translational Modifications Explain Bone Toughness Loss in an Aging Mouse Model Lamya Karim, Atharva Poundarik, Deepak Vashishth 10:05 AMPaper No. 0117 Composition of Human Trabecular Bone Changes with Age and Differs between Anatomical Locations; Evaluation with FTIR Mikael J Turunen, Jukka S Jurvelin, Heikki Kröger, Hanna Isaksson 10:15 AMPaper No. 0118 The Role of Wnt Signaling in Age-Related Impaired Fracture Healing Alison F Kitay, Hayden-William Courtland, Xu Yang, Yen Hsun Chen, Marjolein van der Meulen, Mathias Bostrom, Aaron Daluiski 10:25 AMPaper No. 0119 Notch Signaling Activity in MSC Harvested from Geriatric Mice Patricia L Mutyaba, Hailu Shitaye, Chancellor F Gray, Nicole S Belkin, Derek Dopkin, Jaimo Ahn, Kurt D Hankenson 10:35 AMPaper No. 0120 Exercise Following Disuse Enhances Bone Recovery and Moderates Effects of a Second Bout of Disuse in Adult Rats Yasaman Shirazi-Fard, Estela Gonzalez, Joshua S Kupke, Derrick S Morgan, Joshua M Davis, Susan A Bloomfield, Harry A Hogan 44 9:45 AM - 10:45 AM Bone and Spine Biomechanics Room # 2002 Moderators: Kai-Nan An, PhD and Elise F Morgan, PhD 11:10 AMPaper No. 0122 Correlations between Quantitative MRI and Mechanical Parameters of Human Intervertebral Discs with Different Grades of Degeneration John Antoniou, Laura M Epure, Arthur J Michalek, James Iatridis, Fackson Mwale 11:20 AMPaper No. 0123 Sensitivity of In-Vivo Micro-MRI-based Biomechanics in Detecting Trabecular Bone Loss Wenli Sun, Chamith Rajapakse, Felix Wehrli 11:30 AMPaper No. 0124 3-D Monte-Carlo Simulation on Solute Diffusion through the Pericellular Matrix in Bone Canaliculi Xiaozhou Zhou, Liyun Wang 11:40 AMPaper No. 0125 Shear Strength Behavior of Human Trabecular Bone Arnav Sanyal, Tony Keaveny, Atul Gupta, Harun H Bayraktar, Ron Y Kwon 11:50 AMPaper No. 0126 Effects of Torsion on Disc Height Distribution: An In Vivo Study Nicole Mammoser, Alejandro A Espinoza Orías, Howard An, Gunnar B Andersson, Nozomu Inoue 11:00 AM - 12:00 PM Session 22 Session 23 11:00 AMPaper No. 0127 Specialisation of tendon mechanical properties results from inter-fascicular differences Chavaunne Thorpe, Helen L Birch, Peter D Clegg, Hazel R Screen 11:00 AMPaper No. 0133 Investigating Fracture Risk Classifiers based on Statistical Shape and Density Modeling and the MrOS Data Set Todd L Bredbenner, Robert L Mason, Lorena M Havill, Eric S Orwoll, Daniel P Nicolella Tendon Biomechanics Room # 2005 Moderators: Nelly Andarawis-Puri, PhD and Gail M Thornton, PhD 11:10 AMPaper No. 0128 Investigating age related alterations in the mechanical response of tendon at the fiber level Yufei Li, Gion Fessel, Marcel Abt, Marios Georgiadis, Jess G Snedeker 11:20 AMPaper No. 0129 Highly Inhomogeneous Spatial Properties of Human Supraspinatus Tendon Quantified via Biaxial Mechanical Testing and Anisotropic Inverse Mechanics Spencer P Lake, Prachi M Sheth, Anthony M O’Neil, Ramesh Raghupathy, Victor H Barocas 11:30 AMPaper No. 0130 Regional Material Properties of the Infraspinatus Tendon Differ from Those of the Supraspinatus Spencer E Szczesny, Stephen Liu, John Peloquin, Dawn Elliott, Louis J Soslowsky 11:40 AMPaper No. 0131 Tendon is its Own Strain Gauge: Inherent Electric Properties Consistently Measure Induced Strain Christopher R West, Anton E Bowden 11:50 AMPaper No. 0132 The Development of a Functional Enthesis is Driven by Stress Concentrations at the Tendon-to-Bone Interface Andrea Schwartz, Yanxin Liu, Victor Birman, Guy M Genin, Stavros Thomopoulos Bone Mechanics Room # 2006 Moderators: Jiliang Li, MD, PhD and Joyce H Keyak 11:10 AMPaper No. 0134 Bone Mineral Density (BMD) of Individual Trabecula in Human Trabecular Bone Ji Wang, Bin Zhou, Xiutao T Shi, X. Sherry Liu, X. E Guo 11:20 AMPaper No. 0135 Effects of Tissue-Level Ductility on Trabecular Bone Strength Shashank Nawathe, Frederic Juillard, Tony M Keaveny 11:30 AMPaper No. 0136 Reference Point Indentation in Bone Provides a Reliable Measure Related to Fracture Toughness Oran Kennedy, Matin Lendhey, Jelena Basta-Pljakic, Mitch B Schaffler Sunday, February 5, 2012 Sunday, February 5, 2012 11:40 AMPaper No. 0137 A Nanoscale Examination of Microdamage in Cortical Bone Using Synchrotron Radiation Transmission X-Ray Microscopy Garry Brock, Grace Kim, Joy C Andrews, Anthony R Ingraffea, Marjolein van der Meulen 11:50 AMPaper No. 0138 Digital Image Correlation Identifies Quantitative Characteristics in Proximal Femur Fracture Crack Ian Gerstel, Ramesh Raghupathy, Dan Dragomir-Daescu 45 Sunday, February 5, 2012 Session 24 Session 25 11:00 AMPaper No. 0139 Characterization of Targeted Nanosomes to Detect Damaged Cartilage Hongsik Cho, William J Tidwell, Elsa J Stephen, Dana Pabalate, Evgueni Pinkhassik, Karen A Hasty 11:00 AMPaper No. 0145 Sphingosine-1-Phosphate (S1P) Receptors Modulate Endogenous Stem Cell Mobilization and Homing for Bone Regeneration Anusuya Das, Anjan Kaushik, Anthony Awojoodu, Edward Botchwey Cartilage Degradation Biomarkers and Imaging Room # 2014 Moderators: William A Horton, MD and Katy Georgiadis, PhD Sunday, February 5, 2012 11:10 AMPaper No. 0140 Synovial Fluid Biomarkers Correlate to Pain and are Predictive of Osteoarthritis Progression Philip Band, Hans-Georg Wisniewski, Victoria Luiblinska, Casey Pattanayak, Elisa Colon, Julie Heeter, Raj Karia, Tom Stabler, Endre Balazs, Virginia Kraus 11:20 AMPaper No. 0141 Cationic Contrast Enhanced CT Imaging of Cartilage Predicts Frictional Properties of Articular Cartilage Ben Lakin, Dan Grasso, Prashant Bansal, Mark W Grinstaff, Brian D Snyder 11:30 AMPaper No. 0142 T2 Change Over 24 Months in Subjects with Early Articular Cartilage Degeneration Ashley Williams, Stephen Bruno, Robin West, Freddie H Fu, Constance R Chu 11:40 AMPaper No. 0143 Vibroarthography as an Innovative Non-Invasive Tool for Articular Cartilage Condition Assessment Filip Leszko, Sumesh M Zingde, Thibaut DeBock, Mohamed Mahfouz, Richard D Komistek 11:50 AMPaper No. 0144 Exercise in ACL-Transected Rats Increases Cartilage Roughness Measured by a Novel Digital Method Josef Tofte, Khaled A Elsaid, Ling X Zhang, Kimberly A Waller, Braden C Fleming, Gregory Jay 46 11:00 AM - 12:00 PM Fracture Healing Modulation Room # 2024 Moderators: Douglas J Adams, PhD and Robert J Majeska, PhD 11:10 AMPaper No. 0146 In Vivo Bioluminescence Imaging of Magnetically Targeted Bone Marrow Mesenchymal Stromal Cells Delivery with External Magnetic Force in Bone Fracture Models Akira Kodama, Naosuke Kamei, Goki Kamei, Akihiro Nakabayashi, Wirat Kongcharoensombat, Mitsuo Ochi 11:20 AMPaper No. 0147 MC3T3-E1 osteoprogenitor cells migrate systemically to a bone defect and enhance bone healing Emmanuel Gibon, Barbara Batke, Allison Rao, Kate Fritton, Umar Jawad, Zhenyu Yao, Sandip Biswal, Sam Gambhir, Robert L Smith, Stuart B Goodman 11:30 AMPaper No. 0148 Systemic Inflammation Alters the Cellular Composition of the Early Fracture Callus and Impairs Bone Healing Stefan Recknagel, Ronny B Bindl, Christoph Brochhausen, Tim Wehner, Christian Ehrnthaller, Florian Gebhard, Markus Huber-Lang, Lutz Claes, Anita Ignatius 11:40 AMPaper No. 0149 Fracture Healing in Immune Deficient Nod-Scid IL2Rγnull Mice Ronny B Bindl, Stefan Recknagel, Anna Rapp, Annika Erbacher, Ingo Müller, Anita Ignatius 11:50 AMPaper No. 0150 The effect of cathepsin K inhibitor on murine bone fracture repair Do Yu Soung, Michael A Gentile, Le T Duong, Hicham Drissi 1:30 PM - 3:00 PM Spotlight Session 26 Spotlight Session 27 1:30 PM – 2:00 PM 1:30 PMPaper No. 0157 Rotator Cuff Tendinopathy: Immunohistochemical Changes Across the Spectrum of Pathology Richard J Murphy, Karolina Kliskey, Kim Wheway, David J Beard, Andrew J Carr Current Trends in Joint Replacement Room # 2002 Moderators: Lynne C Jones, PhD and Henrik Malchau, MD Spotlight Speaker: Steve M Kurtz, PhD Current Trends and Projected Utilization of Total Joint Replacements 2:00 PMPaper No. 0151 Survival of Total Hip Arthroplasty with Ceramic-on-Ceramic Bearings Claus Varnum, Alma B Pedersen, Per Kjaersgaard-Andersen, Soeren Overgaard 2:10 PMPaper No. 0152 Single radius of curvature implant design enhances patient lower limb power output following total knee arthroplasty David Hamilton, Paul Gaston, Hamish Simpson 2:20 PMPaper No. 0153 Complications, mortality, and costs after outpatient and short-stay total knee arthroplasty Scott Lovald, Arthur Malkani, Kevin Ong, Edmund Lau, Jordana Schmier, Steve Kurtz, Michael Manley 2:30 PMPaper No. 0154 Implications for Interpreting Implant Registry Recommendations: A Computer Simulation C. Noel, P. Noble 2:40 PMPaper No. 0155 Can Cruciate-Retaining Total Knee Arthroplasty Enhance Knee Range of Motion in Western and Asian Patient Populations?: A Meta -Analysis Takanobu Sumino, Hemanth R Gadikota, Guoan Li, Harry E Rubash 2:50 PMPaper No. 0156 Radiosteriometric Analysis (RSA) of Tapered Femoral Stem in Cementless Total Hip Replacement in Young Patients David C Ayers, Benjamin M Snyder, Marie Walcott, Michelle Aubin, Jacob Drew, Payton Hayes, Mark Eskander, Meridith Greene, Henrik Malchau, Charles R Bragdon Tendon and Ligament: Translational Research Room # 2005 Moderators: Kathleen Derwin, PhD and Hirotaka Sano, MD 1:40 PMPaper No. 0158 Tendon Repair Response to Injury is Affected by the Absence of Biglycan and Decorin Akash Kumar, Andrew A Dunkman, Mark R Buckley, Lydia Pathmanathan, Michael J Mienaltowski, David P Beason, Renato V Iozzo, David E Birk, Louis J Soslowsky 1:50 PMPaper No. 0159 Treadmill Running Prior to Fatigue Loading Mitigates the Effect of Damage Accumulation Nelly Andarawis-Puri, Michael Boniello, Stephen J Ros, Jedd B Sereysky, Evan L Flatow Sunday, February 5, 2012 Sunday, February 5, 2012 2:00 PMPaper No. 0160 Surface Modification Counteracts Adverse Effects of Repaired Tendon Immobilization Chunfeng Zhao, Yu-Long Sun, Gregory Jay, Steven Moran, Kai-Nan An, Peter Amadio 2:10 PMPaper No. 0161 The timing of bone-marrow-derived mesenchymal stem cell injection is critical for long-term benefit to infraspinatus tendon in a sheep model Margaret M Smith, Varshini Ravi, Andrew J Dart, Allan A Young, David H Sonnabend, Christopher B Little 2:20 PMPaper No. 0162 Tendon-derived Stem Cells (TDSCs) Cell Sheet Produced by Connective Tissue Growth Factor (CTGF) and Ascorbic Acid for Tendon Tissue Engineering Ming Ni, Yun Feng Rui, Pauline Po Yee Lui, Gang Li, Kai-Ming Chan 2:30 PM – 3:00 PM Spotlight Speaker: Scott A Rodeo, MD A Clinician-Scientist’s View on Translation of Tendon and Ligament Research to Clinical Care 47 Sunday, February 5, 2012 Spotlight Session 28 Spotlight Session 29 2:00 PMPaper No. 0163 miR-214 negatively correlates with reduced bone formation in both human and mouse bone specimen Xiaogang Wang, Mu Zhu, Yuheng Li, Qi Li, Ge Zhang, Baosheng Guo, Ling Qin, Yinghui Li, Yingxian Li 1:30 PM - 2:00 PM microRNA Room # 2006 Moderators: John S Adams, MD and Cornelia E Farnum, DVM, PhD Sunday, February 5, 2012 2:10 PMPaper No. 0164 Finding Molecular Targets of Heterotopic Ossification Following War Trauma using microRNA Youngmi Ji, Emily H Shin, Matthew W Kluk, Jared A Vogler, Wesley Jackson, Leon J Nesti 2:20 PMPaper No. 0165 Downregulation of microRNAs in Rotator Cuff and Synovium with a Full-thickness Tear Christopher T Chen, Steven K Neeley, Michael K Shindle, Demetris Delos, Russell F Warren 2:30 PMPaper No. 0166 Therapeutically Targeting miR-214 in osteogenic cells promotes bone formation in mice with established osteoporosis induced by ovariectomy Ge Zhang 2:40 PMPaper No. 0167 Therapeutic inhibition of miR-214 promotes osteoblastic bone formation of hind limb suspension mice Yingxian Li, Xiaogang Wang, Baosheng Guo, Qi Li, Ling Qin, Yinghui Li, Ge Zhang 2:50 PMPaper No. 0168 Mechano-responsive microRNA-365 affects post-natal skeletal development in vivo Kun Yang, Qian Chen, Zuoshang Xu, Chunxing Yang 2:30 PM – 3:00 PM Spotlight Speaker: Jane B Lian, PhD MicroRNAs Control the Skeletal Landscape 48 1:30 PM - 3:00 PM Regenerative Approaches for Osteoarthritis Room # 2014 Moderators: Rocky S Tuan, PhD and Hani A Awad, PhD Spotlight Speaker: Farshid Guilak, PhD Stem Cells and Tissue Engineering to Treat Osteoarthritis 2:00 PMPaper No. 0169 Administration of microRNA-210 promotes spinal cord regeneration Satoshi Ujigo, Naosuke Kamei, Hikmat Hadoush, Yuki Fujioka, Shigeru Miyaki, Tomoyuki Nakasa, Toru Sunagawa, Mitsuo Ochi 2:10 PMPaper No. 0170 Dynamic Compressive Loading Enhances Cartilage Matrix Synthesis and Distribution and Suppresses Hypertrophy in hMSC-Laden Hyaluronic Acid Hydrogels Liming Bian, Emily C Zhang, Robert L Mauck, Jason Burdick 2:20 PMPaper No. 0171 Chondrogenesis of Induced Pluripotent Stem Cells: Purification of Differentiated Cells for Tissue Engineering Brian O Diekman, Nicolas Christoforou, Alex Sun, Kam W Leong, Farshid Guilak 2:30 PMPaper No. 0172 Physiologically stiff cartilage with integration to subchondral bone engineered in vitro from hBMSCs Sarindr Bhumiratana, Ryan E Eton, Leo Q Wan, Gordana Vunjak-Novakovic 2:40 PMPaper No. 0173 Altered Mechanosensitivity of Fibrochondrogenic Mesenchymal Stem Cells with Modulation of Nuclear Mechanics Su-Jin Heo, Tristan P Driscoll, Ziwei Zhong, Robert L Mauck 2:50 PMPaper No. 0174 IL-1β enhances chondrogenic and osteogenic differentiation and endochondral priming of human mesenchymal progenitor/stem cells Marcus Mumme, Celeste Scotti, Waldemar Hoffmann, Adam Papadimitropoulos, Sinan Gueven, Marcel Jakob, David Wendt, Ivan Martin, Andrea Barbero Sunday, February 5, 2012 1:30 PM - 3:00 PM Spotlight Session 30 Muscle/Bone Room # 2020-2024 Moderators: Barbara D Boyan, PhD and Johnny Huard, PhD Spotlight Speaker: Lynda F Bonewald, PhD Bone and Muscle Interactions Independent of Loading 2:00 PMPaper No. 0175 Transient Muscle Paralysis Stimulates An Enhanced Anabolic Response to Mechanical Loading Ted S Gross, Edith M Gardiner, Leah Worton, Steven D Bain 2:10 PMPaper No. 0176 Bone abnormalities & impaired bone healing in double knockout utrophin/dystrophin mice Adam Wright, Christian Isaac, Arvydas Usas, Hongshuai Li, Ying Tang, Bing Wang, Johnny Huard 2:20 PMPaper No. 0177 LRP5 Function Influences Cortical Bone Tissue Strength and Toughness in Addition to Bone Quantity Erin McNerny, Margaret Tantillo, Travis Burgers, Bart Williams, Jim Mason, David H Kohn Sunday, February 5, 2012 1:30 PM - 2:00 PM 2:30 PMPaper No. 0178 Load-induced Bone Formation Requires Sensitivity to TGF-β Signaling Simon Tang, Jaquelin Nguyen, Tamara Alliston 2:40 PMPaper No. 0179 FRAP Measurements of Load-Dependency of Solute Transport and Fluid Flow in the LacunarCanalicular System Bin Wang, Xiaozhou Zhou, Wen Li, Christopher Price, Jun Pan, Liyun Wang 2:50 PMPaper No. 0180 Reflection Coefficient of the Pericellular Matrix in the Osteocytic Canaliculi Xiaozhou Zhou, Liyun Wang 49 Daily Meeting Highlights Monday, February. 6, 2012 Room 2002 Room 2006 Registration Open 7:00 AM 8:00 AM Business Meeting Professional Advancement Series III 8:00 AM 9:30 AM Entrepreneurship for Academics in Orthopaedics: How to Get an Idea Out of the University Workshop 8 Clinical Research Forum Heterotopic Ossification in Orthopaedic Trauma Presented by the Orthopaedic Trauma Association - OTA 8:00 am - 9:45 am SESSION I: A Framework for Taking Innovation into Clinical Practice Monday, February 6, 2012 9:00 AM 6:00 PM ORS Awards Presentation / Presidential Address 9:45 AM 11:00 AM Session 31 11:15 AM 12:15 PM Hip and Femoroacetabular Impingement Session 32 Knee and Hip Finite Element Modality 11:35 am - 12:55 pm SESSION III: Metal-onMetal: Were the Studies Strong Enough Before Implementation? 12:15 PM 1:30 PM Poster Walking Tours Tissue Engineering I: Cartilage and Bone Session 39 4:00 PM 6:00 PM Workshop 9 Workshop 10 Focus Areas for Future Research in Total Knee and Total Hip Replacements Presented by the Hip Society and Knee Society Session 33 View Posters & Visit Exhibits 3:00 PM 4:00 PM Room 2024 Building a Successful Research Program: Decisions, Victories and Pitfalls Presented by the ORS Advocacy Committee 10:00 am - 11:20 am SESSION II: The Story of Atypical Proximal Femur Fractures: What About the Unusual Event that Arises After Widespread Use? 12:15 PM 1:30 PM 1:30 PM 2:30 PM Room 2014 Poster and Exhibit Hours Session 35 50 Room 2005 7:00 AM 6:00 PM Tissue Engineering II: Tendon Session 36 Biomaterials Stem Cells and Growth Factors The Post-Traumatic Joint Muscle and Nerve Experimental Models Session 37 2:00 pm - 3:50 pm SESSION IV: BMPs: How do We Detect Adverse Events that We Weren’t Even Thinking About? Meniscus 3:55 pm - 4:30 pm SESSION V: Closing the Loop: Changing Surgeons’ Minds When Confronted with New Information Foot and Ankle Session 40 Polymeric and NanoBiomaterials Session 34 Session 41 Poster & Exhibit Session (Authors Available at Posters to Answer Questions) Session 38 Osteolysis and Implant Fixation Session 42 Growth Factors and Bone Fixation Daily Meeting Highlights and Special Events Co-Chairs: Mohit Bhandari, MD and Theodore Miclau, MD Organizing Committee: Saam Morshed, MD; George Muschler, MD; Kristy Weber, MD and James Wright, MD Clinical Research Forum: The Innovation Cycle: How Can We Avoid Wrong Turns? SESSION I: A Framework for Taking Innovation into Clinical Practice Moderators: Mohit Bhandari, MD and Theodore Miclau, MD 8:00 am Introduction Theodore Miclau, MD and Mohit Bhandari, MD 8:10 am Cycle of Innovation: Is There an IDEAL Approach? Mohit Bhandari, MD 8:25 am Taking Early Innovation into the Clinical Arena: Industry’s Perspective Javier San Martin, PhD 8:40 am Taking Promising Innovation into Clinical Practice. What are the Studies We Should be Doing? James Wright, MD 8:55 am Warning Signs: Monitoring Safety and Adverse Events Barbara Buch, MD 9:10 am My 11 Year Journey on Getting FDA Approval for the STAR Ankle Michael Coughlin, MD 9:25 am Panel Discussion 9:45 am BREAK 8:00 am - 9:45 am SESSION II: The Story of Atypical Proximal Femur Fractures: What About the Unusual Event that Arises After Widespread Use? Moderators: Saam Morshed, MD, PhD and Doug Bauer, MD 10:00 am Looking Back: Did Experimental Evidence Tell us of the Problems with Long Term Bisphosphonate Use? Joseph Lane, MD 10:15 am Making the Observation: From the First Cluster of Events to Quantifying the Risk Rick Dell, MD 10:30 am When are Large Trials not Large Enough to Give us Answers? Dennis Black, PhD 10:45 am Lessons Learned: How do We avoid this from Happening Again? Susan Bukata, MD 11:00am Panel Discussion 11:20 am BREAK 10:00 am – 11:20 am SESSION III: Metal-on-Metal: Were the Studies Strong Enough Before Implementation? Moderators: Kristy Weber, MD and David Jevsevar, MD 11:35 am How Experimental Evidence Drove Innovation Markus Wimmer, PhD 11:50 am How Clinical Case Series Supported Widespread Adoption Young-Min Kwon, MD, PhD 12:05 pm Warning Signs: Events that Lead to Safety Concerns Stuart Goodman, MD, PhD 12:20 pm Lessons Learned from the Metal-Metal Arthroplasty Innovation Cycle Kevin Bozic, MD 12:35 pm Panel Discussion 12:55 pm LUNCH BREAK (Lunch is on your own) 11:35 pm –12:55 pm Clinical Research Forum Morning Session Note: Presentations and Faculty subject to change Afternoon Session SESSION IV: BMPs: How do We Detect Adverse Events that We Weren’t Even Thinking About? Moderators: George Muschler, MD and Gunnar Andersson, MD, PhD 2:00 pm Basic Science and Clinical Data Supporting Therapeutic Efficacy Jeff Wang, MD 2:15 pm BMP Use: Evaluating Industry-Funded Trials Kevin Bozic, MD 2:30 pm Are There Unaddressed Problems Amid Clinical Success? Warning Flags in Published Data and Clinical Experience Eugene Caragee, MD 2:45 pm The Surgeons Dilemma - Perspectives and Sources of Information about Clinical Effectiveness in Off-Label Use Thomas Mroz, MD 3:00 pm Lessons Learned: Where are We? Assessment of Indications, Current Risk, Educational Requirements, Professional and Regulatory Responsibility, Research Implications Dan Spengler, MD 3:15 pm Panel Discussion 2:00 pm –3:50pm 3:35 pm – 4:30pm SESSION V: Closing the Loop: Changing Surgeons’ Minds When Confronted with New Information Moderators: James Wright, MD 3:35 pm – 3:55 pm How to Change Your Mind Scientifically James Wright, MD 3:55 pm – 4:15 pm Panel Discussion/Questions 4:15 pm Conclusion/Adjourn Theodore Miclau, MD 51 WORKSHOPS Monday, February 6, 2012 8:00 AM - 9:30 AM Room 2005 Room 2014 WORKSHOP 8 WORKSHOP 9 HETEROTOPIC OSSIFICATION IN ORTHOPAEDIC TRAUMA FOCUS AREAS FOR FUTURE RESEARCH IN TOTAL KNEE AND TOTAL HIP REPLACEMENTS (Presented by the Orthopaedic Trauma Assocation - OTA) Organizer: Emil H Schemitsch, MD Monday, February 6, 2012 Heterotopic ossification, the formation of bone in soft tissues, represents a clinically important condition in orthopaedic surgery, with particular relevance to orthopaedic trauma. This symposium reviews the pathophysiology, prophylaxis, and treatment of heterotopic ossification, with a focus on this condition in orthopaedic trauma patients and blast injury patients. In addition, the close relationship between central nervous system injury and and heterotopic ossification will be reviewed. This joint symposium with the Orthopaedic Trauma Association will review the latest concepts in heterotopic ossification and orthopaedic trauma. The Pathophysiology of Heterotopic Ossification Leon Nesti, MD, PhD Heterotopic Ossification Prophylaxis in Orthopaedic Trauma Patients Aaron Nauth, MD Treating Heterotopic Ossification in Fracture Patients Emil H Schemitsch, MD Blast Injuries and Heterotopic Ossification Benjamin Potter, MD CNS Injury and Heterotopic Ossification Jaimo Ahn, MD, PhD (Presented by the Hip Society and Knee Society) Organizers: Juan J Rodrigo, MD and Harry E Rubash, MD The significance of this workshop is to have ORS members made aware of the important areas of research that need to be done in total hip and total knee arthroplasty. The main areas to be addressed are knee alignment and kinematics, hip component positions, bearings, registries, complications, and patient satisfaction. Problem areas that have surfaced will be discussed by experts in the field, and ideas for future research will be discussed. The Knee Society: The Hip Society: Senior Speaker: Senior Speaker: Junior Speaker: Junior Speaker: Clifford W Colwell, Jr., MD David G Lewallen, MD Michael D Ries, MD Young-Min Kwon, MD I. Knee Alignment and Kinematics Clifford W Collwell, Jr, MD II. Hip Component Positions - Preoperative Plan and Intraoperative Assessment David G Lewallen, MD III. Bearings Hip Bearing Materials, Edge Loading, Ideal Polyethylene Thickness Young-Min Kwon, MD, PhD Matching Knee and Hip Arthroplasty Materials with Activity Clifford W Colwell, Jr, MD Safety and Efficacy of New Polyethylene for Knee Arthroplasty Michael D Ries, MD IV. Registries Need for Risk Adjustment Tool When Evaluating Registry Results David G Lewallen, MD Risk Stratification for Complications and/or Failure Clifford W Colwell, Jr, MD V. Complications Improving Our Understanding of Metal and Other Component Sensitivity Young-Min Kwon, MD, PhD Etiology and Treatment of Arthrofibrosis Michael D Ries, MD Sepsis - What’s New David G Lewallen, MD 52 Room 2020-2024 Room 2002 WORKSHOP 10 PROFESSIONAL ADVANCEMENT SERIES III BUILDING A SUCCESSFUL RESEARCH PROGRAM: DECISIONS, VICTORIES AND PITFALLS ENTREPRENEURSHIP FOR ACADEMICS IN ORTHOPAEDICS: HOW TO GET AN IDEA OUT OF THE UNIVERSITY (Presented by the ORS Advocacy Committee) Organizers: Stuart B Goodman, MD, PhD, Cathleen L Raggio, MD Building and sustaining a successful multidisciplinary research program is a daunting task, especially for the new investigator. The purpose of this symposium is to provide both the younger and seasoned investigator further insight into the challenges, obstacles, successes and (occasionally) disappointments while establishing a world-class, federally funded research program. Four highly successful researchers will recount their research careers illustrating their stories with specific research questions, problems encountered and how they were solved. Significance: This symposium will facilitate critical assessment by attendees of their own research careers by highlighting how successful musculoskeletal researchers meet the challenges associated with beginning and maintaining a federally funded research program. Building a Successful Research Program: Decisions, Victories and Pitfalls Steven A Goldstein, PhD Building a Successful Research Program: Decisions, Victories and Pitfalls Constance Chu, MD Building a Successful Research Program: Decisions, Victories and Pitfalls Rocky Tuan, PhD The usual orthopedic technical training and research training programs (for example BS, MS, PhD, post-doc and MD) rarely give insight into entrepreneurship in the fields related to orthopedics. While much of the orthopedic device industry is well established, mature and highly profitable, continued innovation will be required to address the changing needs and increasing expectations of patients in the near and distant future. Academic research is often touted as the birthplace of these needed innovations. However, in order for these innovations to reach fruition, these ideas and innovations must be successfully transplanted from academia into industry and grown into successful products. In this program, speakers will discuss their own experiences with entrepreneurship and the challenges associated with translating academic research into products. The Transition from Academia to Industry Anthony Ratcliffe, PhD The Role of the University in Translating Research Michele Marcolongo, PhD Articular Cartilage Stem Cells for Joint Repair: A Case Study in Orthopedic Entrepreneurship in the UK Charlie Archer, PhD Monday, February 6, 2012 WORKSHOPS/PROFESSIONAL ADVANCEMENT SERIES III Monday, February 6, 2012 8:00 AM - 9:30 AM Building a Successful Research Program: Decisions, Victories and Pitfalls Michael Yaszemski, MD, PhD 53 Monday, February 6, 2012 Session 31 Session 32 11:15 AMPaper No. 0181 Hip Kinematics Pre- and Post- Operatively in Subjects with Femoroacetabular Impingement During Stair Climbing Jonathan H Rylander, Beatrice Shu, Jessica Asay, Marc Safran, Thomas Andriacchi 11:15 AMPaper No. 0187 Computationally-optimized mechanical modeling of trabecular bone Ning Zhang, Jeremy Magland, Chamith Rajapakse, Alex Wright, Felix Wehrli Hip and Femoroacetabular Impingement Room # 2002 Moderators: Said T Gomaa, PhD and Nico Verdonschot, PhD 11:25 AMPaper No. 0182 Joint Degeneration Pattern in Severe Pincer Impingement and its Implications for Surgical Therapy Stephen J Ferguson, Emanuel F Liechti, Moritz Tannast Monday, February 6, 2012 54 11:15 AM - 12:15 PM 11:35 AMPaper No. 0183 Dynamic Femoral Head Translations in Dysplastic and Normal Hips Tatsuya Sato, Hiromasa Tanino, Yasuhiro Nishida, Yasuhiro Yamanaka, Toshiki Nakamura, Hiroshi Ito, Takeo Matsuno, Scott A Banks Knee and Hip Finite Element Modality Room # 2005 Moderators: Esther J Tanck, PhD and Jessica E Goetz, PhD 11:25 AMPaper No. 0188 Association between uptake in 18F-fluoride PET and mechanical load stress in the hip joint Yasuhide Hirata, Yutaka Inaba, Naomi Kobayashi, Hiroyuki Ike, Hyonmin Choe, Takashi Ishida, Youhei Yukizawa, Naoyuki Iwamoto, Hiroshi Fujimaki, Taro Tezuka, Tomoyuki Saito 11:35 AMPaper No. 0189 Finite Element Modeling of Proximal Femoral Load Capacity under Fall Loading Joyce H Keyak, Thomas Lang 11:45 AMPaper No. 0184 Effects of Corrective Surgery for Cam Femoroacetabular Impingement on Lower-Extremity Gait Biomechanics Mario Lamontagne, Nicholas Brisson, Matthew J Kennedy, Paul Beaulé 11:45 AMPaper No. 0190 Variation in Medial Meniscus Geometry: Size or Shape Based? Anne Vrancken, Gerjon Hannink, Tony G van Tienen, Marieke J Ploegmakers, Nico Verdonschot, Pieter Buma 11:55 AMPaper No. 0185 Does femoral retroversion affect outcomes for femoral acetabular impingement surgery? Paul Kuzyk, Michael Sellan, Young-Jo Kim, Michael B Millis 11:55 AMPaper No. 0191 Dynamic Finite Element Modeling of Knee Mechanics Daniel P Nicolella, Travis D Eliason, William L Francis, Barron J Bichon 12:05 PMPaper No. 0186 Accuracy of Robotic Assisted Femoral Osteochondroplasty for Treatment of FAI Anil S Ranawat, Hyosig Kang, Snehal Kasodekar, Scott D Nortman, Jennifer A Jones, Michael Conditt 12:05 PMPaper No. 0192 Finite Element Analysis and Computed Tomography Based Structural Rigidity Analysis of Rat Tibia with Simulated Lytic Defects John A Rennick, Ara Nazarian, Vahid Entezari, Hamid NayebHashemi, Ashkan Vaziri, Brian D Snyder 11:15 AM - 12:15 PM Session 33 Session 34 11:15 AMPaper No. 0193 Upregulation of CXCL10 in Synovium and Cartilage following Articular Fracture Bridgette D Furman, Collin L Kent, Adi Kanlic, Amy L McNulty, Farshid Guilak, Steven A Olson 11:15 AMPaper No. 0199 Tensile Poroelastic Material Properties of Whole and Sectioned Skeletal Muscle Adam C Abraham, John T Moyer, Duane A Morrow, Kenton R Kaufman, Tammy Haut Donahue 11:25 AMPaper No. 0194 Cartilage Degeneration and Subchondral Bone Changes due to In Vivo Cyclic Compression Depend on Load Level, Duration, and Anatomical Location in the Adult Mouse Tibia Frank Ko, Cecilia Dragomir, Darren Plumb, Steven Goldring, Timothy Wright, Mary Goldring, Marjolein van der Meulen 11:25 AMPaper No. 0200 A Variant in the Supervillin Gene is Associated with Lean Muscle and Adiposity Phenotypes Karin J Kuhn, Eric Rupe, Clare E Griffis, Mai Abdel-Ghani, Todd Spock, Eric Hoffman, Heather Gordish-Dressman, Pricilla Clarkson, Joseph Devaney, Laura L Tosi The Post-Traumatic Joint Experimental Models Room # 2014 Moderators: Peter van der Kraan, PhD and Liz Pluhar, DVM, PhD 11:35 AMPaper No. 0195 Autophagy Activation by Rapamycin Reduces Severity of Experimental Osteoarthritis Beatriz Carames, Akihiko Hasegawa, Noboru Taniguchi, Shigeru Miyaki, Francisco Javier Blanco, Martin K Lotz 11:45 AMPaper No. 0196 Diet-Induced Obesity Increases Post-traumatic Osteoarthritis Severity in a Mouse Model of Intra-articular Fracture Craig R Louer, Bridgette D Furman, Janet L Huebner, Virginia B Kraus, Steven A Olson, Farshid Guilak 11:55 AMPaper No. 0197 The role of CITED2 in the development and progression of osteoarthritis Daniel Leong, Takuya Ruike, Cecilia Dragomir, Michael J Bronson, Robert J Majeska, Mitchell B Schaffler, Luis Cardoso, Mary B Goldring, Herb B Sun 12:05 PMPaper No. 0198 Twist1 is differentially regulated in normal and osteoarthritic articular cartilage Rosa M Guzzo, Virk Mandeep, Alan Dang, Jay Lieberman, Douglas Spicer, Hicham Drissi Muscle and Nerve Room # 2024 Moderators: Ted S Gross, PhD and Christopher L Mendias, PhD 11:35 AMPaper No. 0201 Inhibition of TGF-b following contraction-induced muscle injury results in an initial improvement but long term deficit in force production Jonathan P Gumucio, Anthony C Phan, Michael D Flood, Susan V Brooks, Christopher L Mendias 11:45 AMPaper No. 0202 Low-Magnitude High-Frequency Vibration Improves Functional Outcomes in Disuse-Induced Atrophied Muscle in Rat Model Keng Ting Sun, Wing Hoi Cheung, Kwok Sui Leung Monday, February 6, 2012 Monday, February 6, 2012 11:55 AMPaper No. 0203 Effects of Vitamin D on rat skeletal muscle regeneration following open muscle injury Ioannis Stratos, Zhengdong Li, Philipp Herlyn, Robert Rotter, Thomas Mittlmeier, Brigitte Vollmar 12:05 PMPaper No. 0204 Combination Treatment of Platelet-Rich Plasma and Angiotensin II Receptor Blocker for Contusion Skeletal Muscle Injury in Mice Satoshi Terada, Shusuke Ota, Tetsuo Kobayashi, Yutaka Mifune, Koji Takayama, Sahnghoon Lee, Burhan Gharaibeh, Tkanobu Otuska, Freddie H Fu, Johnny Huard 55 Monday, February 6, 2012 Session 35 Session 36 1:30 PMPaper No. 0205 Optimization of Composite Scaffold for Osteochondral Interface Tissue Engineering Nora T Khanarian, Rachel A Burga, Nora M Haney, Helen Lu 1:30 PMPaper No. 0211 Modulation of Mesenchymal Stem Cell Chondrogenesis by Injectable and Tunable Hyaluronic Acid Hydrogels Wei Seong Toh, Teck Chuan Lim, Karen K Ng, Motoichi Kurisawa, Myron Spector Tissue Engineering I: Cartilage and Bone Room # 2002 Moderators: A Hadi Reddi, PhD and Steven B Nicoll, PhD 1:40 PMPaper No. 0206 Engineering Osteochondral Constructs through Spatial Regulation of Endochondral Ossification Eamon Sheehy, Tatiana Vinardell, Conor Buckley, Daniel Kelly Monday, February 6, 2012 1:50 PMPaper No. 0207 Mechanical Regulation of Vascular Growth and Bone Regeneration in Vivo Joel D Boerckel, Brent A Uhrig, Nick J Willett, Nathaniel Huebsch, Robert E Guldberg 2:00 PMPaper No. 0208 Applied Osmotic Loading for Promoting Development of Engineered Cartilage Using Synovium-Derived Stem Cells Sonal R Sampat, George P Ackerman, Matthew V Dermksian, Gerard A Ateshian, Clark T Hung 2:10 PMPaper No. 0209 Extracorporeal Shock Wave-Stimulated Periosteum for Orthotopic Bone Generation Cathal Kearney, Hu-ping Hsu, Myron Spector 2:20 PMPaper No. 0210 Development and Evaluation of Optimized Scaffolds Pre-seeded with Effective Progenitor Combination for Vascularized Bone Regeneration Ami R Amini, Cato T Laurencin, Syam Nukavarapu 56 1:30 PM - 2:30 PM Biomaterials Stem Cells and Growth Factors Room # 2005 Moderators: Yunzhi Yang, PhD Robert L Mauck 1:40 PMPaper No. 0212 Influence of Collagen-GAG Scaffold Anisotropy and Composition on Tenocyte and Mesenchymal Stem Cell Bioactivity for Tendon-Bone Repair Brendan A Harley, Steven R Caliari, Daniel W Weisgerber, Manuel A Ramirez, Douglas O Kelkhoff 1:50 PMPaper No. 0213 The Effects of Interactive Mechanical and Biochemical Niche Signaling on Osteogenic Differentiation of Adipose-derived Stem Cells Using Combinatorial Hydrogels Michelle Nii, Michael Keeney, Li-Hsin Han, Galym Imbanayez, Fan Yang 2:00 PMPaper No. 0214 Bioactive Composite Scaffolds for Osteochondral Interface Tissue Engineering Margaret K Boushell, Wendy W Sun, Helen Lu 2:10 PMPaper No. 0215 Bioactive Scaffolds for Vascularized Bone Tissue Engineering Nathaniel S Hwang, Patrick Wu, Haeshin Lee, Robert S Langer, Daniel G Anderson 2:20 PMPaper No. 0216 PLGA-Alendronate enhances bone repair in femoral bone defect in rats Yao-Hsien Wang, R. Eswaramoorthy, Tzu-Lin Tsai, CyongYue Liu, Je-Ken Chang, Mei-Lin Ho 1:30 PM - 2:30 PM Session 37 Session 38 1:30 PMPaper No. 0217 Injection Molded High Density Type I Collagen Gels for Meniscus Tissue Engineering Jennifer L Puetzer, Lawrence Bonassar 1:30 PMPaper No. 0223 Implant Placement Increases Bone Turnover in a Rat Model John M Irish, Amarjit S Virdi, Kotaro Sena, Dale R Sumner 1:40 PMPaper No. 0218 In Vivo Performance of A Silk Derived Scaffold (FibroFix™) For Partial Meniscal Replacement in An Ovine Model Lutz Dürselen, Katharina Gruchenberg, Benedikt Friemert, Falk von Lübken, Nick Skaer, Kris Gellynck, Oliver Kessler, Anita Ignatius 1:40 PMPaper No. 0224 Locally Delivered Alendronic Acid Enhances Net Bone Formation Around Porous Titanium Implants Rebecca E Thompson, Letitia Lim, Miekella Okyere, Kristian M Bobyn, Michael Tanzer, John D Bobyn Meniscus Room # 2014 Moderators: Suzanne A Maher, PhD and Mark Hurtig, DVM 1:50 PMPaper No. 0219 The Effect of Autologous Meniscal Fragment Implantation on Meniscus Regeneration Results from Synergic Effects of Meniscal Matrix and Living Chondrocyte Implantations Yasuyuki Kawaguchi, Eiji Kondo, Nobuto Kitamura, Yasukazu Kobayashi, Masashi Kimura, Shunji Yunoki, Kazunori Yasuda 2:00 PMPaper No. 0220 Intraarticular injection of synovial stem cells promotes meniscal regeneration in rabbit massive meniscal defect Daisuke Hatsushika, Ichiro Sekiya, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Takeshi Muneta 2:10 PMPaper No. 0221 Gene Signature of the Developing Meniscus Dorothy E Pazin, Laura W Gamer, Vicki Rosen 2:20 PMPaper No. 0222 Effect of Lateral Meniscus Tears and Partial Meniscectomy on Stress Concentrations in Knee Joint During Walking Mika E Mononen, Jukka S Jurvelin, Rami K Korhonen Osteolysis and Implant Fixation Room # 2024 Moderators: Roy D Bloebaum, PhD and TBD 1:50 PMPaper No. 0225 High Mobility Group Box-1 (HMGB-1) in Aseptic loose Total Hip Arthroplasty Yasunobu Tamaki, Tomoyuki Hirayama, Yuya Takakubo, Kan Sasaki, Stuart B Goodman, Yrjö T Konttinen, Michiaki Takagi 2:00 PMPaper No. 0226 Could Fluid FLow/Pressure Cause Trabecular Bone Resorption at the Implant-Bone Interface Kenneth Mann, Mark Miller 2:10 PMPaper No. 0227 Do Capsular Pressure and Implant Motion Interact to Cause High Pressure in the Periprosthetic Bone in Cementless Total Hip Replacement? Hamidreza Alidousti, Mark Taylor, Neil W Bressloff Monday, February 6, 2012 Monday, February 6, 2012 2:20 PMPaper No. 0228 Fluid Pressure Induced Osteoclast Activation and Bone Loss is Not Dependent on Fibrous Tissue in the Peri-Implant Zone Anna Fahlgren, Denis Nam, Aleksey Dvorzhinskiy, Mathias Bostrom 57 Monday, February 6, 2012 Session 39 Session 40 3:00 PMPaper No. 0229 Cellular organization in scaffold-free, tissue engineered single tendon fibers Nathan Schiele, Douglas B Chrisey, David T Corr 3:00 PMPaper No. 0235 Presence of Anti-Oxidant containing UHMWPE in an Accelerated Aging Environment Inhibits Oxidation in Neighboring Materials Dermott J McHugh, Steven D Reinitz, Samuel S Streeter, Barbara H Currier, Douglas W Van Citters, John P Collier Tissue Engineering II: Tendon Room # 2002 Moderators: Helen Lu, PhD and Catherine K Kuo, PhD 3:10 PMPaper No. 0230 Effect of MSCs and DBM on Tendon-Bone Healing in a Rabbit Supraspinatus Repair Model Jeffrey P Spalazzi, Renwen Zhang, Sue Coyle, Carlos Aponte, Lin Song, Raymond E Olsen, Layne Norlund, Jake Bair, Twana Davisson Monday, February 6, 2012 3:20 PMPaper No. 0231 CITED2 augments aged tendon stem/progenitor cells in tendon injury repair Takuya Ruike, Daniel Leong, Zhiyong He, Andrew Neviaser, Mia Thi, David Spray, Mitchell B Schaffler, Robert J Majeska, Evan L Flatow, Herb B Sun 3:30 PMPaper No. 0232 Surface Modification Combined Tissue Engineering Patch for Flexor Tendon Repair: A Short-Term In Vivo Chunfeng Zhao, Masanori Hayashi, Yu-Long Sun, Ramona Kirk, Gregory Jay, Steven Moran, Kai-Nan An, Peter Amadio 3:40 PMPaper No. 0233 Fabrication of 3-Dimensional Live Cell-Biomaterial Constructs using a Visible Light-Based Stereolithographic Printer Hang Lin, Dongning Zhang, Guang Yang, Jian Tan, Peter Alexander, Rocky S Tuan 3:50 PMPaper No. 0234 The Effect of Osteogenic Matrix Sheet on Tendon Graft to Bone Tunnel Healing in Rabbits Yusuke Inagaki, Kota Uematsu, Manabu Akahane, Munehiro Ogawa, Yasuaki Tohma, Tomohiko Kura, Yosuke Kayukawa, Yusuke Morita, Kenji Kawate, Yasuhito Tanaka 58 3:00 PM - 4:00 PM Polymeric and Nano-Biomaterials Room # 2005 Moderators: Jørgen Baas, MD, PhD, and Jack E Lemons, PhD 3:10 PMPaper No. 0236 Oxidative Stability of Vitamin E Blended and Subsequently Crosslinked UHMWPE Jordan Freedman, Dave Schroeder 3:20 PMPaper No. 0237 Development and Characterization of Surface Modified PEEK for Bone-Contacting Applications Helmut Thissen, Paul Pasic, Graham Johnson, Penny Bean, Keith McLean, Robert A Poggie 3:30 PMPaper No. 0238 Nanorod-Mediated Assembly of Nanofibrous Laminates through Focused Near-Infrared Exposure Amy M Silverstein, Kolin C Hribar, Jason Burdick, Robert L Mauck 3:40 PMPaper No. 0239 Lipid Microtubes Improve Nutrient Transport in Engineered Cartilage Grace D O’Connell, Clare Gollnick, Gerard A Ateshian, Ravi Bellamkonda, Clark T Hung 3:50 PMPaper No. 0240 Controlled Release of Multiple Growth Factors in 3D-Printed Scaffolds Michelle Poldervaart, Huanan Wang, Sander Leeuwenburgh, Cumhur Oner, Wouter Dhert, Jacqueline Alblas 3:00 PM - 4:00 PM Session 41 Session 42 3:00 PMPaper No. 0241 Correlation of Knee and Hindfoot Deformities in Patients with End-Stage Knee Arthritis Adam Norton, Annunziato Amendola, Phinit Phisitkul, Steve Liu, Siwadol Wongsak, Catherine Fruehling-Wall, John Callaghan 3:00 PMPaper No. 0247 Nell-1 Enhances Bone Formation in an Osteoporotic Sheep Model Michael Chiang, Ann Zhou, Aaron W James, Janette Zara, Raghav Goyal, Karina Covarrubias, Howard B Seim, John Adams, Xinli Zhang, Kang Ting, Chia Soo 3:10 PMPaper No. 0242 Tibiotalar Joint Space Analysis During In Vitro Simulated Gait Joel B Schwartz, Brad Blankenhorn, Megan M Dawson, Michael J Rainbow, Christopher W DiGiovanni, Douglas C Moore 3:10 PMPaper No. 0248 Perlecan/HSPG2 Deficiency Enhances BMP2 Effect on Bone Matrix Secretion and Mineralization Nadia Lepori-Bui, Padma P Srinivasan, Dylan A Lowe, Catherine Kirn-Safran Foot and Ankle Room # 2014 Moderators: James D Michelson, MD and Shepard R Hurwitz, MD 3:20 PMPaper No. 0243 The Relative and Absolute Bone Density at the TMT Joint in Hallux Valgus Muturi Muriuki, Richard F Owens, Darin Nye, Deborah Corson, Carmen Latona, Stephen F Conti, Mark Carl Miller 3:30 PMPaper No. 0244 Talonavicular Joint Coverage and Talar Morphology over Different Foot Types Philip Louie, William R Ledoux, Michael Fassbind, Bruce Sangeorzan 3:40 PMPaper No. 0245 Three-Dimensional Modeling of Screw Placement at the Tarsometatarsal Joint Domingo Molina, Vinod K Panchbhavi, Clark Andersen 3:50 PMPaper No. 0246 Ankle Joint Laxity Correlates with Self-Reported Function in Persons with Chronic Ankle Instability Phillip A Gribble, Brian Pietrosimone, Michelle McLeod Growth Factors and Bone Fixation Room # 2024 Moderators: David Rowe, MD and Julie Glowacki, PhD 3:20 PMPaper No. 0249 F-Spondin (Spondin-1) Null Mice Exhibit Increased Bone Formation Glyn Palmer, Qing Yang, James Liu, Daniel Rifkin, Frank Beier, Mukundan Attur, Steven B Abramson 3:30 PMPaper No. 0250 The role of the Notch signaling ligand Jagged1 in bone Michael Dishowitz, Christina Bales, Kathleen Loomes, Kurt Hankenson 3:40 PMPaper No. 0251 Progranulin Growth Factor Is an Important Mediator of Bone Regeneration Yunpeng Zhao, Qingyun Tian, Chuanju Liu Monday, February 6, 2012 Monday, February 6, 2012 3:50 PMPaper No. 0252 The Regulation of Osteogenesis by SHIP1 William G Kerr, Sonia Iyer, Bryan S Margulies 59 Daily Meeting Highlights Tuesday, February 7, 2012 Room 2002 6:30 AM 7:30 AM RIG: Graduate Student Women’s Group Room 2006 Room 2014 RIG: Bone Tissue: Hierarchical Simulations of Bone for Clinical Application RIG: The Orthopaedic Evidence and Outcomes Education Organization 7:00 AM 5:00 PM Registration Open 7:00 AM 11:45 AM Poster and Exhibit Hours 7:00 AM 8:00 AM Poster Walking Tours 8:00 AM 9:30 AM Workshop 11 Workshop 12 Design, Implementation, Statistical Analysis and Reporting of Clinical Trials in Orthopaedics: A How to for Clinical Trialists Recent Changes at the US Food and Drug Administration with Respect to Orthopaedic Devices Presented by the ORS Corporate Affairs Committee 10:45 AM 11:45 AM Tuesday, February 7, 2012 Knee, ACL, PatelloFemoral Joint Session 47 2:45 PM 4:15 PM 4:30PM 5:30 PM Metal-Metal Bearings: Facts, Fictions and Futures Workshop 14 Clinical Assessment of Acute Joint Injury and Early Joint Degeneration Presented by OARSI and the ORS Poster & Exhibit Session (Authors Available at Posters to Answer Questions) Session 43 1:00 PM 2:30 PM Workshop 13 Room 2024 Keynote Speaker and Incoming Presidential Address 9:45 AM 10:45 AM 60 Room 2005 Shoulder ORS/AAOS Combined Symposium I Adverse Reactions to Byproducts of Joint Replacements Session 44 Tumors and Diseases ORS/AAOS Combined Symposium II Basic and Clinical Science Advances in Understanding Femoracetabular Impingement (FAI) Session 45 Orthopaedic Infection Session 48 Spine Session 46 Cartilage Mechanics Session 49 Session 50 New Polyethylene Implant Wear Knee Arthroplasty Kappa Delta / OREF Paper Presentations RESEARCH INTEREST GROUPS (RIGs) Tuesday, February 7, 2012 6:30 AM - 7:30 AM Room 2002 GRADUATE STUDENT WOMEN’S GROUP Organizers: Tina Nagel and Amy Claeson Room 2006 BONE TISSUE: HIERARCHICAL SIMULATIONS OF BONE FOR CLINICAL APPLICATION Room 2014 THE ORTHOPAEDIC EVIDENCE AND OUTCOMES EDUCATION ORGANIZATION Organizer: Michael Dohm, MD, ABOS, FAAOS Organizer: Maria-Grazia Ascenzi, PhD Room 2002 Room 2006 WORKSHOP 11 WORKSHOP 12 DESIGN, IMPLEMENTATION, STATISTICAL ANALYSIS AND REPORTING OF CLINICAL TRIALS IN ORTHOPAEDICS: A HOW TO FOR CLINICAL TRIALISTS RECENT CHANGES AT THE US FOOD AND DRUG ADMINISTRATION WITH RESPECT TO ORTHOPAEDIC DEVICES Organizer: Joel J Gagnier, PhD (Presented by the ORS Corporate Affairs Committee) Organizers: James J Mason, PhD and Katy Georgiadis, PhD This workshop will provide attendees with a comprehensive overview of how to design, implement, analyze and report a clinical trial in orthopaedic surgery. This workshop will be 70% didactic and 30% practical. Attendees will work through several exercises in order to develop a clinical trial protocol of interest to them. On completion of this workshop, attendees will have an excellent understanding of clinical trials and will have developed a concrete idea of how to procede with their plans for clinical trials. We expect significant interaction amongst the speakers and attendees. Introduction to Clinical Trials, Randomization and Blinding, Recruitment, Assessing and Reporting Adverse Events, Participant Adherence, Reporting of Clinical Trials. Joel J Gagnier, PhD Sample Size Calculations and Power, Baseline Assessment, Data Collection and Quality Control, Monitoring Response Variables and Data Analysis Joseph Beyene, PhD As the US Food and Drug Administration seek to toughen regulation of medical devices under the Obama administration, the future of product innovation in orthopedics has become clouded. It is clear that policies should be consistent and predictable to help small and large companies innovate but at the same time they need to ensure product safety. In this workshop, three speakers, from the FDA, a small company and a large company, will discuss new FDA policies and their impact on orthopedic device development in the US now and in the future. Changes at the FDA: The Inside Perspective Aric D Kaiser, MS Changes at the FDA: A Small Company Perspective Floyd G Larson Changes at the FDA: A Big Company Perspective Laura Williams Tuesday, February 7, 2012 WORKSHOPS Tuesday, February 7, 2012 8:00 AM - 9:30 AM Ethical Issues, Study Population, Basic Sstudy Design, Trial Completion, Systematic Reviews and Meta-analyses Mohit Bhandari, MD 61 WORKSHOPS Tuesday, February 7, 2012 8:00 AM - 9:30 AM Room 2014 Room 2024 WORKSHOP 13 WORKSHOP 14 METAL-METAL BEARINGS: FACTS, FICTIONS AND FUTURES CLINICAL ASSESSMENT OF ACUTE JOINT INJURY AND EARLY JOINT DEGENERATION Organizers: A Seth Greenwald, DPhil(Oxon), Lynne C Jones, PhD, Warren O Haggard, PhD (Presented by the Osteoarthritis Research Society International OARSI and ORS) Organizers: Constance R Chu, MD and Linda J Sandell, PhD One step forward, two steps back is a concerning assessment of the currency of contemporary metal-metal total and surface replacement hip systems employed as a remedy in the treatment of degenerative arthritis. Recently they have received excessive press coverage, most of it of a decidedly negative slant, attributed to adverse local tissue reactions (ALTR). There are peer-reviewed reports in the clinical literature which describe these phenomena resulting in an increased rate of revision. More advanced research tools allow improved understandings of the material, tissue, and biological interactions and effects including hypersensitivity, metallosis and the development of pseudotumors. These are contributory to implant loosening leading to revision with reported decreased patient outcome. The purpose of this workshop is to summarize the current facts, fictions and specificity of future employment of metal-metal bearings. Tuesday, February 7, 2012 62 Bearing Surfaces for Joint Replacement: New Materials or New Problems? Stuart B Goodman, MD, PhD, FRCS(C) Benign Responses to Orthopaedic Implants: Really? Joshua J Jacobs, MD Metal Reactivity: It’s Influence on Primary & Revision Outcomes David W Murray, MD, FRCS What Does the Histology Tell Us? Knowns & Suppositions Thomas W Bauer, MD, PhD What do Retrievals Really Tell Us? Steven M Kurtz, PhD Early diagnosis and treatment of human joint degeneration is considered an important new strategy to delay the onset of disabling osteoarthritis. To evaluate this strategy, sensitive and quantitative clinical assessments of early joint degeneration are needed. This symposium presents expert discussion of human clinical use of novel joint assessment techniques to include high-field MRI of bone, cartilage, synovium and meniscus; optical coherence tomography, new MRI mapping techniques, quantification of inflammation and cytokine profiles; and integration of imaging and biochemical biomarkers. Morphological and Quantitative MRI Assessment of Joint Injury and Early Degeneration Hollis G Potter, MD Clinical Translation of Novel Technologies for Early Diagnosis and Staging of Joint Injury and Degeneration Constance R Chu, MD Novel Assessments of Inflammation in Joint Tissues and Synovial Fluid Carla R Scanzello, MD, PhD ORS/AAOS COMBINED SYMPOSIA Tuesday, February 7, 2012 1:00 PM - 2:30 PM AAOS/ORS COMBINED SYMPOSIUM I Room 2005-2011 ADVERSE REACTIONS TO BYPRODUCTS OF JOINT REPLACEMENT Moderators: Juan J Rodrigo, MD and Stuart B Goodman, MD, PhD This symposium describes antigen-specific (allergic) inflammatory responses to byproducts of joint replacements including histological findings, lymphocyte proliferative responses, radiological and clinical presentations, and methods of antigen testing. Clinical Manifestations of Metal Allergy Joshua J Jacobs, MD The Non-Specific Response to Byproducts of Total Joint Implants Stuart B Goodman, MD, PhD Histological Aspects of Metal Allergies Patricia A Campbell, PhD Basic Immunological Principles of Allergy for the Orthopaedic Surgeon Paul H Wooley, PhD Local Reactions to Metal-on-Metal Implants Young-Min Kwon, MD, PhD Tuesday, February 7, 2012 Testing for Patients for Immune Response/Allergy Nadim J Hallab, MD 63 Tuesday, February 7, 2012 Session 43 Session 44 1:00 PMPaper No. 0253 Effect of Graft Fixation Angles on Knee Kinematics in Double-bundle Anterior Cruciate Ligament Reconstruction Hideyuki Koga, Takeshi Muneta, Ichiro Sekiya 1:00 PMPaper No. 0262 A Novel Oncolytic Virotherapy Using Live-attenuated Poliovirus for Soft Tissue Sarcoma Satoru Atsumi, Akihiko Matsumine, Tomoki Nakamura, Rui Niimi, Takao Matsubara, Kunihiro Asanuma, Atsumasa Uchida, Akihiro Sudo Knee, ACL, Patello-Femoral Joint Room # 2002 Moderators: Scott J Hazelwood, PhD and Paul J Rullkoetter, PhD 1:10 PMPaper No. 0254 Anatomic Double Bundle Anterior Cruciate Ligament Reconstruction Restores Normal Dynamic In Vivo Knee Kinematics Sebastian Kopf, Gele Moloney, Kristin Freismuth, Freddie H Fu, Scott Tashman 1:20 PMPaper No. 0255 The effects of ACL graft placement on femoral cartilage thickness Eziamaka C Okafor, Gangadhar M Utturkar, Margaret R Widmyer, Ermias S Abebe, Dean C Taylor, Charles E Spritzer, Claude T Moorman, William E Garrett, Louis E DeFrate 1:30 PMPaper No. 0256 Contact Stress Patterns across the Tibial Plateau during Gait: Effect of Anterior Cruciate Ligament Injury Tony Chen, Natalie Kelly, Asheesh Bedi, Russell F Warren, Suzanne A Maher Tuesday, February 7, 2012 1:40 PMPaper No. 0257 Patellofemoral Kinematics Before and After Bone-Tendon-Bone Harvest for ACL Reconstruction Richard Peindl, Marshall Kuremsky, Robert Morgan, Michael Hoenig, James Fleischli 1:50 PMPaper No. 0258 In-Vivo Kinematics of Patellofemoral Joint during Dynamic Stair Ascending Takashi Suzuki, Ali Hosseini, Jing-Sheng Li, Thomas J Gill, Guoan Li 2:00 PMPaper No. 0259 Is Patella Alta More Prevalent among Maltracking Patellofemoral Pain Subjects? Saikat Pal, Thor Besier, Christine Draper, Michael Fredericson, Scott Delp, Gary S Beaupre, Garry Gold 2:10 PMPaper No. 0260 A robotic in vivo comparison of 3-dimensional patellar kinematics between healthy volunteers and those with patellofemoral pain syndrome using dynamic computed tomography Tommy J Cunningham, Thomas P Branch, Shaun K Stinton, Tim Mills, Adbulrahma Albahar, Cale Jacobs 2:20 PMPaper No. 0261 Cartilage Stress is not Elevated at 60° of Knee Flexion During Stair Climbing in Subjects with Patellofemoral Pain Thor Besier, Saikat Pal, Christine Draper, Michael Fredericson, Garry Gold, Scott Delp, Gary S Beaupre 64 1:00 PM - 2:30 PM Tumors and Diseases Room # 2006 Moderators: Francis Y Lee, MD and Bang Hoang, MD 1:10 PMPaper No. 0263 Analysis of tumor metastatic factor using low coagulation activity model in mice Kunihiro Asanuma, Akihiko Mtsumine, Yumiko Asanuma, Nobuyuki Akita, Tomoaki Yoshikawa, Kakunoshin Yoshida, Takao Matsubara, Tomoki Nakamura, Takayuki Okamoto, Tatsuya Hayashi, Atsumasa Uchida, Akihiro Sudo 1:20 PMPaper No. 0264 A potential target for the treatment of chordoma: CDC2L1 Xianzhe Liu, Wen Yang, Edwin Choy, Henry Mankin, Hornicek Francis, Zhenfeng Duan 1:30 PMPaper No. 0265 Loss of β-Catenin Induces Multifocal Ectopic Chondroma-like Masses in Adult Mice Motomi Enomoto-Iwamoto, Cheri Sunders, Yoichi Ohta, Mrata Guttenberg, Rika Yasuhara, Kengo Shimono, Naoki Kondo, Shuji Asai, Jacqueline Hecht, Susan Mackem, Di Chen, John P Dormans, Masahiro Iwamoto, Maurizio Pacifici 1:40 PMPaper No. 0266 Mitochondrial Proliferation Induces Apoptosis of Human Malignant Fibrous Histiocytoma Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Masahiro Kurosaka, Toshihiro Akisue 1:50 PMPaper No. 0267 Hedgehog Pathway as the Target in Rhabdomyosarcoma with Gli1 Gene Amplification Kimo Bachiashvili, Jason A Horton, Timothy A Damron 2:00 PMPaper No. 0268 ERK5 Regulates Invasiveness of Osteosarcoma by Inducing MMP-9 Expression Sung Wook Seo, Haewon Lee 2:10 PMPaper No. 0269 Raman Spectroscopy Reveals Strengths and Limitations of Amifostine Protection on Irradiated Bone Bo Gong, Catherine Tchanque-Fossuo, Behdod Poushanchi, Steven R Buchman, Steven A Goldstein, Michael D Morris 2:20 PMPaper No. 0270 Tumor Cells Outside of the Local Bone Marrow Contribute to Generalized Bone Loss James Edwards, Claire M Edwards, Jessica Fowler, Nazanin Ruppender, Julie Sterling, Seint Lwin, Josh Johnson, Andrew Hart, Greg Mundy 1:00 PM - 2:30 PM Session 45 Session 46 1:00 PMPaper No. 0271 A Reproducible Implant Infection Model in Rabbits Jim C Odekerken, Tim J Welting, Boudewijn T Brans, Jacobus J Arts, Geert H Walenkamp 1:00 PMPaper No. 0280 Effect of marrow stimulation on the microarchitecture of the subchondral bone - long-term analysis in a preclinical large animal model Patrick Orth, Lars Goebel, Uwe Wolfram, Mei F Ong, Stefan Gräber, Dieter Kohn, Anita Ignatius, Dietrich Pape, Henning Madry Orthopaedic Infection Room # 2014 Moderators: Amarjit S Virdi, PhD and Alexander C McLaren, MD 1:10 PMPaper No. 0272 Development of a Contaminated Musculoskeletal Wound Model Using a Bioluminescent Staphylococcus aureus Strain Mara L Schenker, Keith Baldwin, Shelley Rankin, Kurt D Hankenson, John L Esterhai, Jaimo Ahn, Samir Mehta 1:20 PMPaper No. 0273 Antimicrobial Properties of Platelet-Rich Plasma-in vitro and in vivo Studies Hongshuai Li, Therwa Hamza, Nina Clovis, Suzanne Smith, John Tidwell, Bingyun Li 1:30 PMPaper No. 0274 Cationic Steroidal Antimicrobial-13 for the Prevention of Perioperative Device Related Joint Infections Kristofer D Sinclair, Ryan Farnsworth, Theresa Pham, Roy D Bloebaum 1:40 PMPaper No. 0275 Evaluation of Anti-Glucosaminidase Monoclonal Antibodies as a Passive Immunization for MethicillinResistant Staphylococcus aureus (MRSA) Osteomyelitis John J Varrone, Erica J Dussmann, Yoon Suk Yi, John L Daiss, Hani Awad, Regis O’Keefe, Stephen Kates, Edward M Schwarz 1:50 PMPaper No. 0276 Contribution of Bacterial Lipopolysaccharide on the Corrosion Kinetics of CoCrMo alloy Mathew Mathew Thoppil, R. Radhakrishnan, C. Nagelli, Cortino Sukotjo, Joshua J Jacobs, Markus Wimmer 2:00 PMPaper No. 0277 Antibiotic and photo-porphyrin combination therapies against S. aureus Sana S Dastgheyb, Helen M Davidson, Brian Pepe-Mooney, Keith E Fitzgerald, Kathryn Gay, David M Eckmann, Russell J Composto, Noreen Hickok 2:10 PMPaper No. 0278 Functionalizing Orthopedic Implants with Silver Nanoparticles to Treat Infection Jae Sung Lee, William L Murphy 2:20 PMPaper No. 0279 Local Delivery of Cis-2 Decenoic Acid from Chitosan to Prevent Biofilm Infection Jessica A Jennings, Warren O Haggard, Harry S Courtney, Joel D Bumgardner Cartilage Mechanics Room # 2024 Moderators: Gerard A Ateshian, PHD, and Jack L Lewis, PhD 1:10 PMPaper No. 0281 High Body Mass Index Increases Diurnal Cartilage Strain in the Human Tibia Margaret R Widmyer, Gangadhar M Utturkar, Holly A Leddy, Jeremy L Coleman, Charles E Spritzer, Claude T Moorman, Louis E DeFrate, Farshid Guilak 1:20 PMPaper No. 0282 The effect of GAG depletion on cartilage nanoscale hydraulic permeability Hadi Tavakoli Nia, Iman Soltani, Yang Li, Eliot Frank, Kamal Yousef-Toumi, Alan J Grodzinsky, Christine Ortiz 1:30 PMPaper No. 0283 Lubricin Null Mouse Chondrocytes Undergo Apoptosis in the Presence of Increased Friction Kimberly A Waller, Ling X Zhang, Matthew L Warman, Gregory D Jay 1:40 PMPaper No. 0284 Validation of Subject-Specific Finite Element Models of the Human Hip Corinne R Henak, Ashley L Kapron, Benjamin J Ellis, Andrew E Anderson, Jeffrey A Weiss 1:50 PMPaper No. 0285 Anatomical Variation of Shear Energy Absorption in Articular Cartilage Jesse L Silverberg, Darvin Griffin, Lawrence Bonassar, Itai Cohen 2:00 PMPaper No. 0286 A Novel High-Throughput System for the Mechanical Analysis of Engineered Cartilage Constructs Brian D Cosgrove, Gary Lewis, Beverly Winarto, Joseph Wong, George R Dodge, Robert L Mauck Tuesday, February 7, 2012 Tuesday, February 7, 2012 2:10 PMPaper No. 0287 The Functional Assessment of Osteochondral Implants for Knee Articular Cartilage Defects: Effect of Implant Modulus John A Anderson, Tony Chen, Florian Wanivenhaus, Kirsten Stoner, Kenneth Ng, Hong Chang Hsu, Russell F Warren, Suzanne P Maher 2:20 PMPaper No. 0288 Structural Tissue Changes and Prolonged Clinical Improvement by Joint Distraction in Treatment of Endstage Knee Osteoarthritis; the Two Years Follow-up Karen Wiegant, Peter M van Roermund, Femke Intema, Anne Karien A Marijnissen, Sebastian Cotofana, Felix Eckstein, Simon C Mastbergen, Floris P Lafeber 65 ORS/AAOS COMBINED SYMPOSIA Tuesday, February 7, 2012 2:45 PM - 4:15 PM AAOS/ORS COMBINED SYMPOSIUM II Room 2005 BASIC AND CLINICAL SCIENCE ADVANCES IN UNDERSTANDING FEMOROACETABULAR IMPINGEMENT (FAI) Moderator: John C Clohisy, MD This combined AAOS and ORS symposium will address the current, contemporary understanding of FAI and will propose areas in need of future investigation. Specifically, the current evidence supporting the concept of FAI will be reviewed. The scientific information regarding hip pathomechanics, disease epidemiology, and prevalence of FAI will be presented. Contemporary strategies for disease stagings including radiography, imaging and biomarkers will be discussed. The current evidence regarding surgical treatment will be analyzed and presented with emphasis on identifying areas in need of investigation. Overall, this symposium will present the current basic and clinical science evidence regarding FAI, contemporary strategies of diagnosis, disease staging and treatment. An emphasis will also be placed on future areas of basic and clinical science investigation. Pathomechanics of FAI Christopher L Peters, MD Disease Epidemiology and Prevalence Michael Leunig, MD Tuesday, February 7, 2012 66 Disease Staging-Radiography and Advanced Imaging Paule Beaule, MD Disease Staging-Biomarkers of Osteoarthritis and Potential for FAI Disease Staging Linda J Sandell, PhD Open Surgical Treatment of Surgical Femoroacetabular Treatment-Current Evidence and Treatment Results Ernie Sink, MD Less-Invasive Surgical Treatment of FAI Current Evidence and Clinical Results Christopher Larson, MD 2:45 PM - 4:15 PM Session 47 Session 48 2:45 PMPaper No. 0289 Effect of Clavicle Shortening on In Vivo Rotations of the Shoulder Complex During Abduction J. Erik Giphart, Jake Hvidston, Michael Torry, Tom Hackett 2:45 PMPaper No. 0298 Combination Therapy with Bone Morphogenetic Protein 2 (BMP-2) and Zoledronic Acid (ZA) Improves Posterolateral Spinal Fusion in a Mouse Model of Neurofibromatosis Type 1 Justin D Bobyn, Anton Rasch, David G Little, Aaron Schindeler Shoulder Room # 2002 Moderators: Richard Debski and Louis J Soslowsky, PhD 2:55 PMPaper No. 0290 In vivo Kinematics of the Symptomatic Glenohumeral Joint in Throwers during a Simulated Cocking Motion Using a 3D-to-2D Registration Technique Hiroki Yamauchi, Masayuki Saka, Toru Yoshioka, Hidetoshi Hamada, Kazuyoshi Gamada 3:05 PMPaper No. 0291 Shoulder Strength Ratio Is Associated With Joint Mechanics And Clinical Outcome After Rotator Cuff Repair Michael J Bey, Jeffrey Haladik, Michael J McDonald, Nicole L Ramo, Patricia Kolowich, Terrence Lock, Vasilios Moutzouros 3:15 PMPaper No. 0292 Age-Related Changes in the Supraspinatus Tendon Richard J Murphy, Karolina Kliskey, Kim Wheway, David J Beard, Andrew J Carr 3:25 PMPaper No. 0293 Effect of Immobilization on a New, Two-Tendon Rat Rotator Cuff Repair Model Sarah Ilkhani-Pour, Lauren N Satchell, Joseph J Sarver, Jennica J Tucker, Chancellor F Gray, Lena Edelstein, ChangSoo Lee, Gerald R Williams, Louis J Soslowsky 3:35 PMPaper No. 0294 Reinforced Fascia Patch Limits Cyclic Gapping of Rotator Cuff Repairs in a Human Cadaver Model Jesse A McCarron, Ryan A Milks, Mena M Mesiha, Amit Aurora, Esteban Walker, Joseph P Iannotti, Kathleen A Derwin 3:45 PMPaper No. 0295 Quantitative analysis of the angle of the bone tunnel for bioabsorbable anchor in arthroscopic Bankart repair Masahito Yoshida, Hideyuki Goto, Masahiro Nozaki, Yasuhiro Nishimori, Masaaki Kobayashi, Yuko Nagaya, Noriyuki Watanabe, Hirotaka Iguchi, Yasuhiro Banno, Takanobu Otsuka 3:55 PMPaper No. 0296 Classic and Congruent Latarjet Techniques: An In-Vitro Biomechanical Comparison Joshua W Giles, Harm Boons, Ilia Elkinson, Kenneth Faber, Louis Ferreira, George Athwal, James Johnson 4:05 PMPaper No. 0297 Consequences of Concomitant Subscapularis Repair with Reverse Total Shoulder Arthroplasty Brian R Onstot, Adam G Suslak, Ryan Colley, Marc C Jacofsky, James C Otis, Matthew L Hansen Spine Room # 2006 Moderators: Adam H Hsieh, PhD and TBD 2:55 PMPaper No. 0299 The Effect of Aging on Posterior Intertransverse Lumbar Fusion: A New Zealand White Rabbit Model Michael D Daubs, Andy Tyser, Sarina K Sinclair, Brandon Lawrence, Alpesh A Patel, Jacob Adams, Darrel S Brodke 3:05 PMPaper No. 0300 Does the Cement Stiffness Affect Re-fracture of Vertebrae After Cement Augmentation in Osteoporotic Patients? Rebecca Kueny, Jan P Kolb, Klaus Püschel, Andreas Boger, Johannes M Rueger, Michael M Morlock, Wolfgang Lehmann, Gerd Huber 3:15 PMPaper No. 0301 Long-term effects of photodynamic therapy on healthy vertebrae alone and in combination with bisphosphonate or radiation therapy Victor C Lo, Margarete K Akens, Lisa Wise-Milestone, Albert J Yee, Brian C Wilson, Cari M Whyne 3:25 PMPaper No. 0302 Hyaluronan Nanoparticle-Mediated Delivery of Xylosyltransferase I and Glucuronyltransferase I for Stimulation of Glycosaminoglycans Production in Intervertebral Disc Estelle Collin, Sunil Mahor, Michelle Kilcoyne, Doris Hendig, Sibylle Grad, Mauro Alini, Abhay Pandit 3:35 PMPaper No. 0303 Potential of Parathyroid Hormone for Suppressing Calcification in Human Intervertebral Discs and Promoting Repair Fackson Mwale, Padma Madiraju, John Antoniou 3:45 PMPaper No. 0304 Tissue Engineered Disc Replacement. Long term outcome in a rat spinal model Andrew R James, Robby D Bowles, Harry Gebhard, Robert I Mozia, Hollis G Potter, Matthew Koff, Sarah Pownder, Lawrence Bonassar, Roger Hartl Tuesday, February 7, 2012 Tuesday, February 7, 2012 3:55 PMPaper No. 0305 A Force Sensor With No Electrical Connections For Orthopaedic Smart Implants Rebecca A Wachs, Keegan P Cole, David Ellstein, David B Fiorella, Kenneth A Connor, Eric H Ledet 4:05 PMPaper No. 0306 Quantitative Comparison of UHMWPE Wear Particles Generated from SB Charité III Total Disc Replacements Tested Under Different Input Kinematics Joanne L Tipper, Rachel Vicars, Polina Prokopovich, Thomas Brown, Eileen Ingham, John Fisher 67 Tuesday, February 7, 2012 Session 49 Session 50 2:45 PMPaper No. 0307 Early Indications of Oxidative Degradation in Retrieved Annealed UHMWPE Bearings Resembles Gamma Sterilized Materials Steven D Reinitz, Barbara H Currier, Katherine J Franklin, Meagan E Tibbo, Douglas W Van Citters, John P Collier 2:45 PMPaper No. 0316 Knee Kinematics in ACL Substituting Arthroplasty With or Without PCL Toshifumi Watanabe, Masafumi Ishizuki, Takeshi Muneta, Nicholas Dunbar, Alex Iorgulescu, Scott A Banks New Polyethylene Implant Wear Room # 2014 Moderators: Harry A McKellop, PhD and John M Martell, MD 2:55 PMPaper No. 0308 Squalene-initiated oxidation at low temperature displays the effect of free radicals in cross-linked UHMWPE Andrew Neils, Ebru Oral, Orhun K Muratoglu 3:05 PMPaper No. 0309 Can UHMWPE be Crosslinked without Radiation or Loss of Mechanical Properties? D.c. Sun, Anuj Bellare, David Brooks, Mark Allen, Steve Lin, Ruy Tsay 3:15 PMPaper No. 0310 Probabilistic assessment of fatigue failure data on ultra high molecular weight polyethylenes Francisco Javier Pascual Aranzana, M. López-Aenlle, L. Gracia, José Antonio Puértolas, A. Fernández-Canteli Tuesday, February 7, 2012 3:25 PMPaper No. 0311 Lipid Doping and Aging of Various UHMWPEs Zachary Konsin, Keith Wannomae, Orhun K Muratoglu 3:35 PMPaper No. 0312 Wear Performance of a Dual Mobility Hip under Abrasive Conditions LaQuawn Loving, Henry Mena, Reginald Lee, Lizeth Herrera, Aaron Essner 3:45 PMPaper No. 0313 Protein State Affects the Morphology UHMWPE Wear Debris Michel P Laurent, Shravan Sarvepalli, Yasha Dwivedi, George Michael, Tom Schmid, Markus A Wimmer 3:55 PMPaper No. 0314 14yrs Long-term Performance of Crosslinked PE: Sustained Wear Reduction and less Osteolysis? Bernd Grimm, Alfons Tonino, Ide C Heyligers 4:05 PMPaper No. 0315 A Prospective, Blinded, Double-Randomized Radiosteriometric Analysis (RSA) of Tantalum vs. Titanium Acetabular Shells and Highly Cross-linked vs. Conventional Polyethylene Liners in Young THA Patients David C Ayers, Benjamin M Snyder, Marie Walcott, Michelle Aubin, Jacob Drew, Payton Hays, Mark Eskander, Meridith Greene, Henrik Malchau, Charles R Bragdon 68 2:45 PM - 4:15 PM Knee Arthroplasty Room # 2024 Moderators: John D DesJardins, PhD and Shantanu Patil, MD 2:55 PMPaper No. 0317 Intra-Operative Assessment Of Mid-Flexion Instability In Total Knee Arthropalsty Yukihide Minoda, Shigeru Nakagawa, Yoshinori Kadoya, Akio Kobayashi, Kazuhide Tomari, Makoto Kondo, Hiroyoshi Iwaki, Mitsuhiko Ikebuchi, Taku Yoshida, Yoshio Matsui, Akira Sumitomo, Ryo Sugama, Shigekazu Mizokawa, Yasuo Higuma, Takahiro Noguchi, Masashi Hirakawa, Hiroaki Nakamura 3:05 PMPaper No. 0318 Utilization of High Flexion after Unicompartmental Knee Arthroplasty Donna M Scarborough, Nikhil R Thiruvengadam, Scott A Foster, Andrew A Freiberg, Henrik Malchau, James I Huddleston 3:15 PMPaper No. 0319 Newly Developed Navigation System for Minimally Invasive Total Knee Arthroplasty Yusuke Yokoyama, Nobuhiro Abe, Kazuo Fujiwara, Masahiko Suzuki, Yoshikazu Nakajima, Naohiko Sugita, Mamoru Mitsuishi, Koichi Kuramoto, Yoshio Nakashima 3:25 PMPaper No. 0320 Accuracy of the Reconstruction of 3D Human Knee Joint Surface Models Using Dual Fluoroscopic Images Zhonglin Zhu, Guangzhi Wang, Guoan Li 3:35 PMPaper No. 0321 Ethnic and Gender Differences in Proximal Tibial Plateau Morphology Yifei Dai, Mary Wentorf, Jeffrey E Bischoff 3:45 PMPaper No. 0322 The Influence of Malrotation and Material of the Femoral Component on Patellofemoral Contact Mechanics and Wear During Gait Jean-Philippe Luyckx, Luc Labey, Christophe Verlinden, Jens Vanbiervliet, Bernardo Innocenti, Johan Bellemans, Hilde Vandenneucker 3:55 PMPaper No. 0323 Relative Contributions of Design, Loading and Alignment Variability in TKR Clare Fitzpatrick, Chadd W Clary, Justin Hollenbeck, Peter J Laz, Paul Rullkoetter 4:05 PMPaper No. 0324 Comparison of Total Knee Arthroplasties with Oxidized Zirconium and Cobalt-Chromium Femoral Components in the Same Patients. -In Vivo Comparison of Wear Particles Young-Hoo Kim, Jang-Won Park, Jun-Shik Kim POSTERS 69 Posters POSTER SESSIONS The ORS will have two Poster Sessions in San Francisco, California. Posters will be located on Level Three of the Moscone West Convention Center. Poster Session 1 (PS1): Posters displayed Saturday and Sunday Poster Session 2 (PS2): Posters displayed Monday and Tuesday The 35 NIRA finalists will display their poster the entire meeting, Saturday – Tuesday. Dedicated poster and exhibit hours. The two evening poster sessions are mandatory for ALL authors to stand next to their poster to answer questions during their assigned poster session (PS1 or PS2). NEW: Authors will choose additional time they will be available to stand by their poster. A sheet will be posted on each poster board and completed by the author indicating the additional times they will be at the poster to answer questions. POSTER SESSION 1 Saturday, February 4 12:00 pm – 1:30 pm 4:15 pm – 6:00 pm MANDATORY FOR AUTHORS TO STAND BY POSTER Authors of Even numbered posters – 4:15 – 5:10 Authors of Odd numbered posters – 5:05 – 6:00 Sunday, February 5 12:00 pm – 1:30 pm 3:00 pm – 4:30 pm POSTER SESSION 2 Monday, February 6 12:15 pm – 1:30 pm 4:00 pm – 6:00 pm MANDATORY FOR AUTHORS TO STAND BY POSTER Authors of Even numbered posters – 4:00 – 5:00 Authors of Odd numbered posters – 5:00 – 6:00 Tuesday, February 7 7:00 am – 8:00 am 10:45 am – 11:45 am 70 Poster Session 1 #’s Poster Session 2 #’s AAOS Best Poster AAOS1 - AAOS7 AAOS1 - AAOS7 Arthroplasty 0932 -1090A 1921 - 2078 Biomaterials 0592 - 0643 1581 -1630 Bone 0360 - 0388, 0404 - 0428, 0496 - 0554 1347 - 1375, 1395 - 1419, 1488 - 1543 BOS Best Poster BOS1 - BOS10 BOS1 - BOS10 Cancer/Tumors 0466 - 0495 1458 - 1487 Cartilage/Meniscus/Synovium 0681 - 0833 1668 - 1830 Cell & Molecular Biomechanics 0391 - 0403 1380 - 1394 Disease Process Hip 0868 - 0881 1860 - 1876 Disease Process Knee 0834 - 0866 1831 - 1859 Foot & Ankle 0898 - 0907 1893 - 1901 Fracture Fixation 0429 - 0441 1420 - 1433 Gait and Kinematics 0883 - 0897 1877 - 1892 Imaging 0442 - 0465 1434 - 1457 Infection and Inflammation 0908 - 0925 1902 - 1920 Ligament and Tendon 1288 - 1346 2279 - 2336 Muscle Posters Poster Categories 2255 - 2278 Muscle/Nerve 1264 - 1287 NIRA Finalists 0325 - 0359 0325 - 0359 Progenitors & Stem Cells 0555 - 0591 1544 - 1580 Publications 1376 - 1379 Skeletal Growth and Development 0389 - 0390 Spine 1092 - 1207 2079 - 2200 Tissue Engineering 0644 - 0679 1631 - 1667 Trauma 0926 - 0931 Upper Extremity 1208 - 1263 2201 - 2254 71 Board of Specialty Societies American Academy of Orthopaedic Surgeons BEST POSTERS BEST POSTERS Posters BOS 1 American Association for Hand Surgery- AAHS Title TBD Authors TBD BOS 2 The American Orthopaedic Society for Sports Medicine-AOSSM Changes in Serum Biomarkers of Cartilage Turnover Following ACL Reconstruction Steven J Svoboda, Travis Harvey, William Brechue, Brett D Owens, Kenneth L Cameron BOS 3 American Society for Surgery of the Hand-ASSH The Effect of Collagen Nerve Conduits Filled with Collagen-GAG Matrix on Peripheral Motor Nerve Regeneration in a Rat Model Joo-Yup Lee, Guilherme Giusti, Patricia F Friedrich, Allen T Bishop, Alexander Y Shin BOS 4 Cervical Spine Research Society -CSRS Positive Cervical Sagittal Alignment Negatively Impacts Outcomes Following Adult Cervical Fusion Procedures Jessica A Tang, Justin K Scheer, Vedat Deviren, Shay Bess, Robert Hart, Virginie Lafage, Christopher Shaffrey, Frank Schwab, Christopher P Ames BOS 5Cervical Spine Research Society -CSRS Quantitative Tracing of Spared Tract Fibers after Contusive Spinal Cord Injury by in vivo Diffusion Tensor Tractography: Nonhuman Primates Study Tsunehiko Konomi, Kenehiro Fujiyoshi, Keigo Hikishima, Yuji Komaki, Osahiko Tsuji, Hideyuki Okano, Yoshiaki Toyama, Masaya Nakamura BOS 6 Musculoskeletal Tumor Society-MSTS Anti-Interleukin 8 Therapy Inhibits Tumor-Induced Osteolysis and Tumor Progression Corey O Montgomery, Richard Nicholas, Larry Suva BOS 7 North American Spine Society-NASS Augmentation of Spinal Fusion with Intermittent PTH (1-34) in an Ovariectomized Rat Posterolateral Spinal Fusion Model with Iliac Crest Bone Graft Huilin Yang, Qui Zhijie, Molly Ebraheim, Sohaib Hashmi, Miguel A Linares, Jr, Mustafa H Khan, Jiayong Liu BOS 8 Orthopaedic Trauma Association-OTA Mesenchymal Stem Cells (MSCs) Facilitate Fracture Repair in an Alcohol- Induced Impaired Healing Model Thomas S Obermeyer, Kristen Lauing, Stuart R Stock, David Yonick, Michael D Stover, John J Callaci BOS 9 Scoliosis Research Society-SRS Would CoCr Rods Provide Better Correctional Forces than Stainless Steel or Titanium for Rigis Scoliosis Curves? Devdatt Mhatre, Peter O Newton, Paul A Giorgio, Peter Sturm, Hassan Serhan BOS 10 The Pediatric Orthopaedic Society of North America-POSNA Referral Patterns To A Pediatric Orthopaedic Clinic: Pediatric Orthopaedic Surgeons Are Primary Care Musculoskeletal Medicine Physicians William Hennrikus, John Kobilis, Jane Hamp 72 AAOS 1 - Spine Staging Regimen in Adult Spinal Deformity Surgery Impacts Functional Outcome, Complications & Total Hospital Days Hamid Hassanzadeh AAOS 2 - Tumor and Metabolic Disease Loss Of The Fibrinolytic Protease, Plasminogen, Leads To Early Degeneration Of Appendicular And Axial Skeleton Jesse Bible, Heather Cole, Jeffry Nyman, Masato Yuasa, Dave Gailani, Clinton Devin, Jonathan Schoenecker AAOS 3 - Foot and Ankle Ankle Distraction Arthroplasty: How Much is Enough? Thomas H McCoy Jr, Austin Fragomen, Kate Meyers, S Robert Rozbruch AAOS 4 - Shoulder and Elbow Shoulder Glenoid Revision to Reverse Implant: Clinical and Radiological Results Using a Modular System Carlo F DiBiase, Stefano Gumina, Mario Borroni, Alessandro Castagna, Franco Postacchini AAOS 5 - Adult Reconstruction Hip A comparison of Metal on Metal to Metal on Highly Cross-linked Polyethylene Total Hip Replacements Monti Khatod AAOS 6 - Hand and Wrist The Prospective Analysis of Ultrasound in the Injection of DeQuervains Disease Asif Ilyas, James McDermott, Levon Nazarian, Charles Leinberry AAOS 7 - Adult Reconstruction Knee Early Survivorship of Fixed versus Mobile Bearing Unicompartmental Knee Arthroplasty Jason Masonis, Jeffrey Krempec, Walter Beaver The 35 NIRA finalists will display their poster the entire meeting, Saturday – Tuesday. NIRA 1: Cartilage and Spine Poster No. 0325 Human CD133 positive cells with a magnetic delivery system promote functional recovery in rat spinal cord injury Yuki Fujioka, Nobuhiro Tanaka, Kazuyoshi Nakanishi, Naosuke Kamei, Toshio Nakamae, Bunichiro Izumi, Ryo Ohta Poster No. 0326 Elevated Lysyl hydroxylase 2b expression during experimental OA; the potential cause of persistent synovial fibrosis Dennis Remst, Esmeralda Blaney Davidson, Elly L Vitters, Ruud A Bank, Wim B van den Berg, Peter M van der Kraan Poster No. 0327 Analysis of the Proliferative Response of Fibroblasts Obtained From Arthrofibrotic Tissue Chaoxu Liu, Roland Meister, Carl Haasper, Christian Krettek, Michael Jagodzinski Poster No. 0334 Development of siRNA Technology to Prevent Scarring and Adhesion Formation after Tendon Repair Sirish K Kondabolu, Kiminori Yukata, Shanshan Shi, Jennifer Jonason, TianFang Li, Hani A Awad, Regis J O’Keefe Poster No. 0335 Cellular and molecular interactions in flexor tendon repairs: Towards regenerative scarless healing Subhash C Juneja, Regis J O’Keefe, Edward M Schwarz, Hani A Awad Poster No. 0336 In Vivo ACL Length Change During High Demanding Activity Yuichi Hoshino, Gele Moloney, Freddie H Fu, Scott Tashman Poster No. 0337 PTHrP Regulates the Modeling of Entheses During Linear Growth Meina Wang, Joshua VanHouten, Randy L Johnson, Guoying Liang, Arthur E Broadus Poster No. 0338 The Role of Cellular Retinol Binding Protein 1 (CRBP1) in Regulating Function of Mesenchymal Stem Cells Liangliang Xu, Fanbiao Meng, Gang Li NIRA 3: Cartilage Biology and Osteoarthritis Poster No. 0328 A Critical Role of Parathyroid Hormone Type 1 Receptor in Postnatal Growth and Maintenance of Intervertebral Disc Fanjie Zeng, Mu Xiao, Ming Xue, Xinping Zhang Poster No. 0339 Regulation of Cartilage Homeostasis Genes by Matrilin-3: Dependency on Interleukin-1 Receptor Antagonist Chathuraka T Jayasuriya, Mary B Goldring, Richard M Terek, Qian Chen Poster No. 0329 Direct Cartilage Repair Using 3D Bioprinting Technology Xiaofeng Cui, Kurt Breitenkamp, M.g. Finn, Martin Lotz, Darryl D’Lima Poster No. 0340 Mmp13 is A Critical Target Gene during the Development of Osteoarthritis Jie Shen, Meina Wang, Hongting Jin, Erik Sampson, Hee-Jeong Im, Di Chen Poster No. 0330 The Viscoelastic Recovery of Chondrocytes In Situ after Static and Dynamic Compressions Sang Kuy Han, Ryan Madden, Walter Herzog Poster No. 0331 Signal Heterogeneity on Cartilage T2 Maps Predict Rapid Symptomatic Progression of OA Kenneth Urish, Matthew Keffalas, John Durkin, David Miller, Constance Chu, Timothy Mosher NIRA 2: Soft Tissue Poster No. 0332 Finite Element Analysis of Median Nerve Stresses in Carpal Tunnel Syndrome Patients and Matched Normals Jessica E Goetz, Thomas E Baer, Daniel R Thedens, Ericka A Lawler, Thomas Brown Poster No. 0333 Acceleration of Tendon-Bone Healing of Anterior Cruciate Ligament Graft Using Autologous Ruptured Tissue Tomoyuki Matsumoto, Seiji Kubo, Ken Sasaki, Yohei Kawakami, Shinya Oka, Koji Takayama, Hiroshi Sasaki, Katsumasa Tei, Takeshi Ueha, Takehiko Matsushita, Yutaka Mifune, Masahiro Kurosaka, Ryosuke Kuroda Posters New Investigator Recognition Award (NIRA) Posters The following posters will also be presented in the NIRA Presentations on Saturday, February 4 from 3:15 – 4:15 pm. See session schedule for date and time of each presentation. Poster No. 0341 Transcription Factor Erg Is Required for Long-term Articular Cartilage Maintenance Yoichi Ohta, Takahiro Okabe, Shuji Asai, Agnese Di Rocco, Colleen Larmour, Motomi Enomoto-Iwamoto, Maurizio Pacifici, Masahiro Iwamoto Poster No. 0342 A selective c-Fos/AP-1 inhibitor prevents cartilage destruction in a mouse model of osteoarthritis Hiraku Motomura, Yoshito Matsui, Shoji Seki, Shunichi Shiozawa, Tomoatsu Kimura Poster No. 0343 Annexin A6 Accelerates Osteoarthritis Progression by Stimulating NF-κB Activity Kirk Campbell, Takeshi Minashima, Scott Hadley, Martin Quirno, You Jin Lee, Thorsten Kirsch Poster No. 0344 Reduced Expression of Collagen type IX in Human Osteoarthritic Chondrocytes is Associated with Epigenetic Silencing by DNA Hypermethylation Kei Imagawa, Maria C de Andrés, Ko Hashimoto, Eiji Itoi, Mary B Goldring, Richard O Oreffo 73 Posters Poster No. 0345 Exosomes function in a novel communication pathway among joint tissue cells in OA pathogenesis Tsuyoshi Takada, Shigeru Miyaki, Yoshihiro Nakamura, Tomohiro Kato, Tomoyuki Nakasa, Yoshio Kato, Martin K Lotz, Mitsuo Ochi Poster No. 0355 Specific Biomimetic Hydroxyapatite Nanotopographies Enhance Bone Isograft Osteointegration Alayna Loiselle, Lai Wei, Gregory Lewis, Emmanuel Paul, Akhlesh Lakhtakia, Henry Donahue NIRA 4: Fracture Repair Poster No. 0356 In Vivo Evaluation of Biochemically and Mechanically Guided Implant Osseointegration Jason P Long, Steven A Goldstein Poster No. 0346 Cartilage Grafts: An improved mechanism to promote bone regeneration? Chelsea S Bahney, Diane Hu, Theodore Miclau, Ralph Marcucio Poster No. 0347 Erythropoietin improves bone repair in atrophic non-unions Joerg H Holstein, Marcel Orth, Claudia Scheuer, Andrea Tami, Patric Garcia, Tina Histing, Tim Pohlemann, Michael D Menger Poster No. 0348 T-Lymphocytes Enable Osteoblast Maturation During Early Phases of Fracture Repair Diane Nam, Elaine Mau, Yufa Wang, David Silkstone, Cari Whyne, Benjamin Alman Poster No. 0349 Intermittent Teriparatide (hPTH 1-34) Treatment Rescues an Impaired Fracture Healing in COX-2 Mutant Mice Kiminori Yukata, Chao Xie, Tian-Fang Li, Jennifer Jonason, Xinping Zhang, Hani A Awad, Edward M Schwarz, Regis J O’Keefe Poster No. 0350 Anti-Dkk1 Antibody Promotes Bone Fracture Healing through Activation of β-Catenin Signaling Hongting Jin, Meng Mi, Matthew Hilton, Hee-Jeong Im, Hua-Zhu Ke, Philip Babij, Di Chen Poster No. 0351 Suicide Gene Therapy Approach with a Dual Expression LV Vector Enhances the Safety of Ex Vivo Gene Therapy for Bone Repair Farhang Alaee, Osamu Sugiyama, Mandeep Virk, Amy Tang, Alex Lichtler, Jay Lieberman Poster No. 0352 Intravital Imaging Mesenchymal Stem Cell-Mediated Skeletal Repair in vivo Chunlan Huang, Vincent Ness, Edward Brown, Xinping Zhang NIRA 5: Bone Poster No. 0353 The Effect of Wnt on Bone Marrow Transplant in a Critical Size Calvarial Defect Jie Jiang, Stefanie D Monica, Johnathan J Urena, Andrew Liao, Jill A Helms Poster No. 0354 Role of donor and host cyclooxygenase-2 in muscle derived stem cell mediated bone healing in critical sized calvarial defect model Xueqin Gao, Arvydas Usas, Aiping Lu, Ying Tang, Minakshi Poddar, Jessica C Tebbets, Mathieu Huard, James H Cummins, Johnny Huard 74 Poster No. 0357 Low Intensity Vibrations Attenuate the Age-Related Bone Loss and Immune System Damage Induced by Obesity Meilin E Chan, Kim Kawatra, Michelle Cheung, Danielle Green, Ben Adler, Ada H Tsoi, Mario E Botros, Clinton T Rubin Poster No. 0358 A Mechanosensory Role for the Primary Cilium in Human Mesenchymal Stem Cells David A Hoey, Shane J Tormey, Fergal J O’Brien, Christopher R Jacobs Poster No. 0359 Evaluation of Spatial Variation in Tissue-level Mechanical Properties of Small Animal Cortical Bone under Diametral Compression Devendra Bajaj, Rohit Belman, James C Fritton POSTER SESSION 1 PS1 Bone Mechanics Poster No. 0360 In vivo fracture healing assessment using a novel biomicroelectromechanical system Kirk McGilvray, Hilmi Demir, Emre Unal, Kevin Troyer, Rohat Melik, Christian Puttlitz Poster No. 0361 A new method for measurement of bone bending stiffness noninvasively by echo tracking Kenji Tobita, Isao Ohnishi, Juntaro Matsuyama, Takuya Matsumoto, Satoru Ohashi, Masahiko Bessho, Masako Kaneko, Kozo Nakamura Poster No. 0362 Three point bending- vs torsion-testing of BMP-treated rat femora Per Bosemark, Hanna Isaksson, Magnus Tägil Poster No. 0363 CT-based Finite-Element Analysis and Structural Rigidity Analysis to assess Failure Load in Bones with Simulated Lytic Defects Lorenzo Anez-Bustillos, Ara Nazarian, Nico Verdonschot, L. Derykx, Brian Snyder, Esther Tanck Poster No. 0364 Anatomic Variations of the Plate-Rod Microstructure in Human Trabecular Bone Bin Zhou, Ji Wang, Xiutao T Shi, Xiaowei Sherry Liu, X.Edward Guo Poster No. 0365 Inter-Individual Variability of Bone Density and Morphology Distribution in the Proximal Femur Javad Hazrati Marangalou, Bert van Rietbergen, Lorenzo Grassi, Fulvia Taddei, Keita Ito Poster No. 0367 Effect of Osteoid on Trabecular Surface Strains in Human Cancellous Bone as Estimated from Microcomputed Tomography-Based Large Scale Finite Element Analysis Yener Yeni, Lily Huang, Tushar Shetty, Shuaib Raza, Srikant Nekkanty Poster No. 0368 Functional Interactions Among Morphological and Tissue-Quality Traits in the Proximal Femur Yan Epelboym, N. Remi Gendron, Jillian Mayer, Joseph Fusco, Philip Nasser, Gary Gross, Richard Ghillani, Karl J Jepsen Poster No. 0369 Correlation of Local Mechanical Environment to Induced Tissue Phenotype Gregory J Miller, Louis C Gerstenfeld, Elise F Morgan Poster No. 0370 Quantification of Microvasculature after Osteogenic Mechanical Loading using Magnetic Resonance Imaging Ryan E Tomlinson, Gary S Ye, James D Quirk, Matthew J Silva Poster No. 0371 Osteogenic Response to Damaging Mechanical Loading Is Diminished by Inhibition of Angiogenesis Ryan E Tomlinson, Anne H Schmieder, Gregory M Lanza, Matthew J Silva Poster No. 0372 Mice with Conditional Knockout of Connexin43 Have Greater Femoral Strength Than Wild Type Controls Following Three Weeks of Mechanical Unloading via Hindlimb Suspension Shane A Lloyd, Yue Zhang, Emmanuel M Paul, Shavona Burton, Henry J Donahue Poster No. 0373 The Mechanical Consequence of Acute Bone Loss Following Spinal Cord Injury William B Edwards, Danielle D Barkema, Thomas J Schnitzer, Karen L Troy Poster No. 0374 Bone Loading Estimation in the Human Distal Radius Patrik Christen, Bert V Rietbergen, Ingrid Knippels, Ralph Müller, Harry van Lenthe, Keita Ito Poster No. 0375 Effect of Partial Dehydration on the Toughness of Young and Old Cortical Bone Jeffry S Nyman, Lacey E Gorochow, Adam Horch, Matthew R Murry, Mark D Does Poster No. 0376 The Microstructure of the Human Calcaneus and its Effect on Anisotropic Poroelastic Ultrasound Mohammad F Souzanchi, Paolo E Palacio-Mancheno, Yuri Borisov, Luis Cardoso, Stephen C Cowin Poster No. 0377 Black bears with longer disuse (hibernation) periods have lower femoral osteon population density and greater mineralization Sarah Gray, David Weyland, Meghan McGee-Lawrence, Samantha Wojda, Seth Donahue Poster No. 0378 Microstructural, Material, Densitometric, Metabolic and Mechanical Variations in Cortical and Trabecular Bones from Normal, Ovariectomized and Vitamin D Deficient Rats Lorenzo Anez-Bustillos, Shima Aran, Andrew Luu, Francisco Araiza Arroyo, Vahid Entezari, Claudio Rosso, Brian D Snyder, Ara Nazarian Posters Poster No. 0366 Diagnosis of Cam-type Impingement Using Three-Dimensional HeadNeck Ratios Charles S Marquardt, Milad Masjedi, Isabella Drummond, Justin Cobb Poster No. 0379 Rats with High Intrinsic Aerobic Capacity Retain Increased Femoral Cortical Thickness with Aging Jacqueline H Cole, Joseph S Tramer, Logan E White, Lauren G Koch, Steven L Britton, Ronald F Zernicke, Kenneth M Kozloff Poster No. 0380 Plate-Rod Microstructural and Mechanical Differences between Hip Fracture and Non-Fracture Trabecular Bone Bin Zhou, Ian Parkinson, Ji Wang, Xiaowei Sherry Liu, C David L Thomas, John Clement, Nick Fazzalari, X.Edward Guo Poster No. 0381 Site-specific and anisotropic differences of bovine bone strength measured by reference point indentation Alexander M Proctor Poster No. 0382 In Situ Deformation of Bone Mineral Crystals Under Tensile and Compressive Loads Bijay Giri, Jonathan D Almer, Xuanliang N Dong, Xiaodu Wang Poster No. 0383 Development of Functional Interactions Among Cortical and Trabecular Traits in the Lumbar Vertebral Body Melissa Ramcharan, Meghan E Faillace, Zoe Guengerich, Valerie A Williams, Karl J Jepsen Poster No. 0384 Whitening occurs in Demineralized Bone Michael R Hardisty, Tanya Garcia-Nolen, Scott Choy, Justin Dahmubed, Susan Stover, David P Fyhrie Poster No. 0385 Boundary Conditions in Nonlinear µCT Image Based Finite Element Modeling Do Not Affect Predictions in Yield Strength of Human Trabecular Bone Xiutao T Shi, Bin Zhou, Mark F Adams, X. E Guo Poster No. 0386 A Novel Method Demonstrating That µFEA Can Successfully Identify Damage in Whole Vertebrae Ryan Herblum, Cari Whyne Poster No. 0387 In-vivo tibial loading in mice: The effect of loading history on cortical and trabecular bone formation Michael Brodt, Matthew J Silva, Michelle E Sanchez, Akhil Kotiya, Michelle Lynch 75 Posters Poster No. 0388 Direct 3-D Correlation of Strain to Damage Formation in Rat Femora Following Fatigue Loading Joshua A Gargac, Travis Turnbull, Ryan K Roeder, Glen L Niebur PS1 Skeletal Growth and Development Developmenal Biology Poster No. 0389 Developmental Dysplasia of the Hip (DDH)-like Phenotype in Immobilized Chick Embryos Niamh C Nowlan, James Sharpe Poster No. 0390 Growth and development of fetal trabecular micro-architecture Richard Abel, Dimitris Reissis PS1 Cell w Molecular Biomechanics - Physical Ef fects on Cells Poster No. 0391 Effects of Hypoxia on Human Mesenchymal Stem Cells Shun-Pei Hung, Jennifer H. Ho, Yu-Ru V Shih, Ting Lo, Oscar K. Lee Poster No. 0392 Comparative effects of hydrostatic compression and shear stress on early mechano responsive gene expression of human MSC: both induce gene response Morad Bensidhoum, Laure Sudre, Thierry Hoc, Eric Perrin, Herve Petite Poster No. 0393 Cell fate regulation of human mesenchymal stem cells by threedimensional nano-topography of silicon nanowires Shu-Wen Kuo, Hsin-I Lin, Yu-Ru V. Shih, Ta-Jen Yen, Oscar K. Lee Poster No. 0394 Mesenchymal Stem Cell Fate is Regulated by the Mechanical Properties and Composition of CollagenGlycosaminoglycan Scaffolds Ciara M Murphy, Amos Matsiko, John P Gleeson, Fergal J O’Brien Poster No. 0395 A Study of Wnt and Notch Signaling in the Muscle Stem Cells of Accelerated-aging Mouse Model Xiaodong Mu, Koji Takayama, Kurt R Weiss, Johnny Huard Poster No. 0396 Proliferation and Differentiation Potential of Adipose-Derived Stem Cells Isolated from Dystrophin and Utrophin Knockout Mice Adam Kozemchak, Jihee Sohn, Nick Oyster, Seth Thompson, Aiping Lu, Ying Tang, Burhan Gharaibeh, Bing Wang, Johnny Huard Poster No. 0397 Effect of 3D Arrangement on Myogenic Differentiation Amy Powless, Laura Meszaros, Kimimasa Tobita, Anand Kumar 76 Poster No. 0398 Primary Cilia Exhibit 2D and 3D Sensitivity to Substrate Environment: Implications for Adipose Stem Cells in Musculoskeletal Tissue Engineering Josephine C Bodle, Candace D Rubenstein, Michelle E Phillips, Adisri Charoenpanich, Susan H Bernacki, Elizabeth G Loboa Poster No. 0399 Effects of Mechanical Stimulation on Differentiation of AdiposeDerived Stem Cells Kai Megerle, Whitney Cole, Ian Mahaffey, James Chang, Alesha B Castillo Poster No. 0400 Mechanical Loading Induces Loading-Intensity Dependent Effects on Aging Tendon Stem Cells Jianying Zhang, Sen Lin, James H Wang Poster No. 0401 TGFβ mediated mechanical regulation of matrix turnover in Human Tenocytes Eleanor R Jones, Gavin C Jones, Kirsten Legerlotz, Graham P Riley Poster No. 0402 The Adhesion Strengths of Epithelial Cells after TGF-β1 Inducing EMT by Micro-Mechanical Testing System Tsung-Hsien Wu, Chia-Huei Li, Jen-I Liang, Ming-Long Yeh Poster No. 0403 Changes in collagen orientation and proteoglycan content four weeks after anterior cruciate ligament transection modulate cell morphology in mechanically loaded rabbit cartilage Siru Turunen, S. Han, Walter Herzog, Rami K Korhonen PS1 Bone Fracture Poster No. 0404 A Small Interfering RNA Targeting Lnk Using Atelocolagen as a Scaffold is Effective in Treatment of Unhealing Bone Fracture via Early Neovascularization Yohei Kawakami, Tomoyuki Matsumoto, Masaaki Ii, Atsuhiko Kawamoto, Yutaka Mifune, Tomoaki Fukui, Taro Shoji, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara Poster No. 0405 Acceleration of Fracture Healing in Mouse with Deficiency of G-Protein Coupled Estrogen Receptor 1 James Phelps, Sagar Patel, Brigham Au, Rahul Banerjee, Joseph Borreli, Christopher T Chen Poster No. 0406 Optimal bone fracture resistance requires local remodeling of cortical bone matrix through a matrix metalloproteinase-13dependent mechanism Simon Tang, Ralf-Peter Herber, Sunita Ho, Tamara Alliston Poster No. 0407 Fgfr3 G374R mutation causes increased bone formation during fracture healing Shun Murakami, Ajay R Singh, Zhufeng Ouyang Poster No. 0409 Effects of Parathyroid Hormone Treatment on Osteogenic/ Chondrogenic Differentiation of Human Fracture Hematoma-Derived Cells in Vitro Yoshihiro Dogaki, Sang Yang Lee, Takahiro Niikura, Akihiro Koh, Takaaki Koga, Etsuko Okumachi, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 0410 Mice with Pten deleted in osteoblasts have more robust fracture healing assessed by 3D µCT analysis Travis Burgers, Martin A Alvarado, Martin F Hoffmann, Debra L Sietsema, Bart O Williams, Clifford B Jones, Jim Mason Poster No. 0411 Pharmacological Activation of Canonical Wnt Signaling Promotes MSC Differentiation into the Osteoblast Lineage for Improvement of Fracture Healing Tripti Gaur, John J Wixted, Sadiq Hussain, Ivo Kalajzic, Jennifer L Colby, MaryClare McCorry, Stacey Russell, Andre J van Wijnen, Janet L Stein, David W Rowe, Gary S Stein, Jane B Lian Poster No. 0412 Inhibition of Sclerostin by Monoclonal Antibody Enhances Bone Healing in Rat Osteotomy Model Yixin He, Zhong Liu, Chi-wai Man, Lizheng Zheng, Tao Tang, Ho-Kiu Chow, PK Suen, Chao-Yang Li, Hua Z Ke, Ge Zhang, Ling Qin Poster No. 0413 Pantoprazole, a proton pump inhibitor, delays bone remodeling during fracture healing in mice Tina Histing, David Stenger, Claudia Scheuer, Wolfgang Metzger, Patric Garcia, Joerg H Holstein, Moritz Klein, Tim Pohlemann, Michael Menger Poster No. 0414 Temporal Effects of Low Intensity Pulsed Ultrasound (LIPUS) on rhBMP-2 Induced Bone Formation in a Critical Sized Segmental Defect in the Rat Siddhesh R Angle, Kotaro Sena, Dale R Sumner, Walter W Virkus, Amarjit S Virdi Poster No. 0415 rhBMP-2 and Demineralized Bone Matrix Result in Similar Fracture Healing in Delayed- and Nonunion Treated with a Modified Hernigou’s Technique Saad M Hasan, Andre D Shaffer, Aasis Unnanuntana, Joseph M Lane Poster No. 0416 Comparative Evaluation of BMP-2 and FTY720 for Bone Regeneration in Critical Size Cranial Defects Anusuya Das, Dan Barker, Edward Botchwey Poster No. 0417 Evaluation of rhBMP-2/ACS/TCP-HA bone graft composite with addition of unprocessed Bone Marrow cells in a Canine Femoral Multi Defect Model Viviane Luangphakdy, Kentaro Shinohara, Hui Pan, Cynthia Boehm, Aneta Samaranska, Theresa Hefferan, George Muschler Poster No. 0418 Synergy between living bone particles and rhBMP-2 in the healing of large segmental defects in the rat femur Fangjun Liu, Elisabeth Ferreira, Ryan M Porter, Vaida Glatt, Alan Ivkovic, James Wells, Mark Vrahas, Christopher Evans Poster No. 0419 BMP-7 Induces Reproducible Healing in Rodent Critical Sized Defect Model Using a Novel Mini-Locking Plate Joel C Williams, Matthew J Anderson, Blaine A Christiansen, A Hari Reddi, Mark A Lee Posters Poster No. 0408 The Role of Nrf2 in fracture healing Rainer Beckmann, Sebastian Lippross, Stefan Brüggemann, Ferda Özdogru, Mersedeh Tohidnezhad, Nadine Steubesand, Philipp Lichte, Melanie Pufe, Deike Varoga, Graeme M Campbell, Claus C Glüer, Andreas Seekamp, Hans-Christoph Pape, Yuet Wai Kan, Thomas Pufe, Christoph Wruck Poster No. 0420 Effect of Low-Intensity Pulsed Ultrasound on BMP7-induced Osteogenic Differentiation of Human Nonunion Tissue-Derived Cells in Vitro Takaaki Koga, Sang Yang Lee, Takahiro Niikura, Akihiro Koh, Yoshihiro Dogaki, Etsuko Okumachi, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 0421 Effectiveness of OP-1 in the Treatment of Radiation-Induced Atrophic Non-Union in a Rat Femoral Fracture Model Fred H Nicholls, Katarina Janic, Thomas Willett, Marc Grynpas, Peter Ferguson Poster No. 0422 Adamts5 knockout mice exhibit a deficiency in callus formation after femoral fracture Rhima Coleman, Jun Li, Adele L Boskey, John Sandy, Anna Plaas Poster No. 0423 Gene Expression of RGK Family (Rad, Rem1, and Rem2) in the Experimental Nonunions and Standard Healing Fractures Yoshihiro Dogaki, Takahiro Niikura, Sang Yang Lee, Akihiro Koh, Takaaki Koga, Etsuko Okumachi, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 0424 Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture Healing Vikram Sathyendra, Hank J Donahue, Kent E Vrana, Arthur Berg, J Spence Reid Poster No. 0425 A biomechanical evaluation of the interprosthetic distance as a risk factor for periprosthetic fractures of the femur: Does the gap distance matter? Kristoff Corten, Olivier L Segal, Thomas Quirynen, Johan Bellemans, Jean-Pierre Simon Poster No. 0426 A Framework for Estimating Bone Strength Along the Distal Radius and the Effect of Eccentric Axial Load Position David W Wagner, Derek Lindsey, Gary S Beaupre Poster No. 0427 Quantification by micro-CT of the architectural changes in bone and callus in a rat closed fracture healing model Phil Salmon, Michelle M McDonald, Nicole Y Yu, Alyson Morse, David Little Poster No. 0428 Effect of Thresholding on μCT assessment of Fracture Repair in Mice Jeffry S Nyman, Timothy A Unger, Kevin O’Neill, Nicholas Mignemi, Matthew R Murry, Heather Cole, Daniel P Perrien, Christopher Stutz, Jonathon G Schoenecker 77 PS1 Fracture Fixation Posters Poster No. 0429 Mechanical Effects of Off-Axis Insertion of Locking Screws - Should we do it? Jacob L Cartner, Tim Petteys, Paul Tornetta Poster No. 0430 Angular stability of locking screws in intramedullary nails does not improve their mechanical performance Peter Augat, Florian Hoegel, Patrick Weninger, Stephanie Hoffmann Poster No. 0431 The Effect of Two Distal Interlocking Screw Configuration and Orientation on Intramedullary Nail Stability: A Biomechanical Study Preston S Jones, Alexander Chong, Bradley R Dart, Vinh Pham, Adam J Rogg, Joel White, Paul H Wooley Poster No. 0432 A Divergent Screw Orientation is Superior to a Parallel or Convergent Screw Orientation during the Fixation of Vertical Shear Fractures of the Medial Malleolus Derek F Amanatullah, Safdar Khan, Shane Curtiss, Philip Wolinsky Poster No. 0433 Optimal Fixation for Horizontal Medial Malleolus Fractures Derek F Amanatullah, Erik McDonald, Adam Shellito, Shain Lafazan, Alejandro Cortes, Shane Curtis, Philip Wolinsky Poster No. 0434 Does Number and Orientation of Locked Screws Matter for Unstable Intertrochanteric Fixation Andy Whitten, Jacob L Cartner, Zane M Hartsell, Toney Russell Poster No. 0435 Bone substitute reduces significantly the secondary loss of reduction: A biomechanical study of tibial depression fractures Stefanie T Doht, Teresa Lehnert, Torsten Blunk, Sönke Frey, Kai Fehske, Rainer H Meffert Poster No. 0436 WITHDRAWN Poster No. 0437 Augmentation of Trauma Hardware in a Proximal Femoral Osteotomy Model - Pilot Study and Proof of Concept Nicole Fawns, Suzanne Stewart, Thomas P Schaer 78 Poster No. 0441 Telemetric monitoring of bone healing in femoral nonunions treated by an internal fixator Klaus Seide, Nils Weinrich, Birgitt Kowald, Christian Juergens, Majed Aljudaibi, Joerg Mueller, Maximilian Faschingbauer PS1 Imaging Poster No. 0442 Rapid Dose-Dependant Degenerative Changes in Lumbar Intervertebral Discs after Chondroïtinase Injection Quantified by Biomechanical, MRI and Histological Parameters Cornelis P Paul, Gustav J Strijkers, Magda de Graaf, Arno Bisschop, Albert J van der Veen, Theo H Smit, Marco N Helder, Barend van Royen, Margriet G Mullender Poster No. 0443 Comparison of Regions of Interest Segmented from MRI and Histology in a Rabbit Model of Disc Degeneration Won C Bae, Jade He, Tomonori Yamaguchi, Nozomu Inoue, Koichi Masuda Poster No. 0444 Effects of Space Flight on T2 MR Properties of Mouse Intervertebral Discs Won C Bae, Nita Chen, Tomonori Yamaguchi, Graeme M Bydder, Alan R Hargens, Koichi Masuda Poster No. 0445 Quantitative assessment of early lumbar intervertebral disc degeneration using axial T2 mapping and delayed gadoliniumenhanced magnetic resonance imaging (dGEMRIC) Atsushi Sugawara, Hideki Murakami, Satoshi Yoshida, Toshiki Akasaka, Ken Yamazaki, Tadashi Shimamura Poster No. 0446 Magnetic resonance imaging of proximal femur predicts the marrow cellularity and the numbers of mesenchymal stem cells Kuen Tak Suh, Jae Min Ahn, Jung Sub Lee, Jung Yun Bae Poster No. 0447 Quantitative MRI Detects Regional Variation in Knee Articular Cartilage of Healthy and Osteoarthritic Subjects Melissa A Vogelsong, Ernesto Staroswiecki, George Pappas, Brian A Hargreaves, Eric Han, Anne L Friedlander, Marc R Safran, Garry E Gold Poster No. 0438 Maintaining Distal Femur Plate-Screw Stability - 7 years of Studies Jacob L Cartner, Paul Tornetta, Yanming Zheng, Ramona Soileau, Andy Whitten, Zane M Hartsell, Bob Jones, William Ricci Poster No. 0448 Direct Comparison of Intra-articular versus intra-venous delayed Gadolinium Enhanced Magnetic Resonance Imaging of Hip Joint Cartilage Christoph Zilkens, Falk Miese, Marcus Jäger, Harish S Hosalkar, YoungJo Kim, Tallal Mamisch, Gerald Antoch, Rüdiger Krauspe, Bernd Bittersohl Poster No. 0439 Locking plates versus long stem fixation to restore pre-fracture mechanics of a B1 periprosthetic femoral fracture Jonathan Mak, Lee Etchels, Mehran Moazen, Alison C Jones, Ruth K Wilcox, Zhongmin Jin, Eleftherios Tsiridis Poster No. 0449 Intra-articular Viscosupplementation Improves Proteoglycan Content in Superficial Knee Cartilage by T1 rho MRI Roshan P Shah, Jeffrey B Stambough, Matthew Fenty, Robert L Mauck, John D Kelly, Ravinder Reddy, Fotios P Tjoumakaris Poster No. 0440 Fracture Fixation Determines the Pathway of Osseous Repair: A bilateral femur fracture model in the rat David E Jaffe, David J Yoo, Gregory Gasbarro, Jason Blevins, Tyler Hughes, Benjamin Schultz, Joseph P Stains, Vincent D Pellegrini Poster No. 0450 Comparison of Three Methods to Quantify Repair Cartilage Collagen Orientation Lisa Fortier, Keir Ross, Hollis G Potter, Rebecca Williams, Lauren Schnabel, Gino Bradica, Emme Castiglione, Ryan Saska Poster No. 0452 Regional Variation of Short Echo Time T2 and T1rho Measurement in Menisci from Osteoarthritic Subjects Min-Sun Son, Stuart B Goodman, Brian Hargreaves, Weitian Chen, Garry Gold, Marc E Levenston Poster No. 0453 Correlation of ex-vivo T1rho MR imaging of osteo-arthritic cartilage with localized immuno-histochemical grading Keerthi Shet, Fei Liang, Eunice Fu, Tamara Alliston, Andrew Hovai, Michael Ries, Xiaojuan Li Poster No. 0454 A Comparison of T1ρ- and T2*-weighted MRI as diagnostic tools for assessing articular cartilage in impact vs. non-impact female collegiate athletes Sebastian Peers, Tristan Maerz, Erin Baker, Anil Shetty, Steffan Puwal, Yang Xia, Joseph Guettler Poster No. 0455 T1 and T2 Mapping of a Chondroitin Sulfate Gelatin Model Neil Mardis, Sri Alapati, Tammy Brown, Donna Pacicca Poster No. 0456 Quantifying Image Distortion of Orthopedic Materials in Magnetic Resonance Imaging Matthew Koff, Parina Shah, Kevin Koch, Hollis G Potter Poster No. 0457 Quantitative 3D Diffusion Musculoskeletal Imaging Bragi Sveinsson, Ernesto Staroswiecki, Garry E Gold, Brian A Hargreaves Poster No. 0458 Can x-ray morphometric parameters for the hip be assessed on magnetic resonance imaging? Andreas Hingsammer, David Stelzeneder, Jeffrey Tsang, Michael B Millis, Tallal C Mamisch, Young-Jo Kim Poster No. 0459 Abnormal joint kinematics may accelerate degeneration of ACL reconstructed knees: correlation of MR T1rho and motion analysis Abbas Kothari, Richard B Souza, Samuel J Wu, Deepak Kumar, Benjamin Ma, Xiaojuan Li Poster No. 0460 Quantitative Magnetic Resonance Imaging (MRI) Morphological Analysis for Knee Cartilages in Healthy and Anterior Cruciate Ligament-injured Knees Hong Li, Ali Hosseini, Jing-Sheng Li, Thomas J Gill, Guoan Li Poster No. 0461 Musculoskeletal MRI at 3.0T and 7.0T: Relaxation Times and Image Contrast Caroline Jordan, Manojkumar Saranathan, Neal K Bangerter, Brian A Hargreaves, Garry E Gold Poster No. 0462 Radiofrequency Induced Heating On or Near Passive Metallic Implants at 1.5T and 3.0T Uche D Monu, Pauline W Worters, Brian A Hargreaves, Garry E Gold Poster No. 0463 Quantification of Bone Marrow Water and Lipid Composition in OA and ACL-Injured Knees using 3D MR Spectroscopic Imaging Lauren S Tufts, Keerthi Shet Vishnudas, Sharmila Majumdar, Xiaojuan Li Posters Poster No. 0451 Age Related Changes in T1ρ and T2 relaxation Times of Knee Cartilage Samuel J Wu, Deepak Kumar, Subburaj Karupppasamy, Pia Jungmann, Lorenzo Nardo, Anthony Luke, Thomas Link, Sharmila Majumdar, Xiaojuan Li, Richard Souza Poster No. 0464 Estimation of 3D shape and internal density of proximal femur by combining DXA images with shape and density templates Sami P Väänänen, Jukka S Jurvelin, Hanna Isaksson Poster No. 0465 The Assessment of Biological Treatment in Patients with Rheumatoid Arthritis Using FDG-PET/CT Koichi Okamura, Yukio Yonemoto, Yukiko Arisaka, Kimihiko Takeuchi, Tetsuya Kaneko, Tsutomu Kobayashi, Kenji Takagishi PS1 Cancer/Tumors Poster No. 0466 High mobility group box chromosomal protein 1 increases migration and α5β1 integrin expression through PI3K, Akt, c-Jun-dependent pathway in human chondrosarcoma cells Yun-Ting Keng, Ju-Fang Liu, Chih-Hsin Tang Poster No. 0467 ETV5 is a Regulator of MMP2 and Bone Resorption in Human Chondrosarcoma Patricia Power, Shalini Singh, Isabella Mak, Michelle Ghert Poster No. 0468 CCL2 increases migration and MMP-9 expression via CCR2 receptor, Ras, Raf, MEK, ERK and NF-κB-dependent pathway in human chondrosarcoma cells Chia-Chun Tsai, Chin-Hsin Tang Poster No. 0469 Diagnostic and therapeutic implications of the oncogene LRF in chondrosarcoma Jasper Yik, Ratna Kumari, Huan Li, Cathy Carlson, Dominik R Haudenschild, Paul Di Cesare Poster No. 0470 AMD3100 Inhibits Angiogenesis and Metastasis in Chondrosarcoma In Vivo Richard M Terek, Cherie Charbonneau, Xiaojuan Sun Poster No. 0471 1-Benzyl-2-phenylbenzimidazole, a benzimidazole derivative, triggers chondrosarcoma cell apoptosis via caspase-dependent and independent pathways Chun-Han Hou, Ju-Fang Liu, Chih-Shin Tang, Chih-Shiang Chang, ShengMou Hou Poster No. 0472 Inhibitors of histone deacetylases (HDACs) induce cell death in Chondrosarcoma and Osteosarcoma cell lines in two and three dimensional cell cultures Marcus Tonak, Konstantin Horas, Andreas A Kurth 79 Posters Poster No. 0473 Infliximab suppresses the lung metastasis in osteosarcoma cell line Hiroaki Kato, Hiroki Wakabayashi, Akihiko Matsumine, Akihiro Sudo Poster No. 0474 Notch Inactivation Reduces Aldehyde Dehydrogenase (ALDH) Activity In Osteosarcoma Cells Xiaodong Mu, Christian Isaac, Riddhima Agarwal, Johnny Huard, Kurt R Weiss Poster No. 0475 Acridine Orange Inhibits Pulmonary Metastasis and Invasion on Mouse Oseteosarcoma Haruhiko Satonaka, Koji Akeda, Katsuyuki Kusuzaki, Masaya Tsujii, Takahiro Iino, Takeshi Uemura, Tomoki Nakamura, Takao Matsubara, Kunihiro Asanuma, Akihiko Matsumine, Akihiro Sudo Poster No. 0476 Role of HEY1 in osteosarcoma metastasis Arisa Tsuru, Yukihiro Matsunoshita, Satoshi Nagano, Setsuro Komiya, Takao Setoguchi Poster No. 0477 Gene Coexpression in Primary Sarcomas Transcends Tumor Histotype R. Lor Randall, Albert J Aboulafia, Timothy A Damron, Kevin B Jones, David E Joyner Poster No. 0478 Mouse Models for the Cellular Origin of Ewing’s Sarcoma Liu Yang, Howard A Chansky, Anna Zielinska-Kwiatkowska Poster No. 0479 EWS-CHOP Myxoid Liposarcoma Fusion Protein Represses Osteopontin and Col11a2 Collagen Gene Transcription in Pluripotent Mesenchymal C3H10T1/2 Cells Kayo Suzuki, Yoshito Matsui, Mami Higashimoto, Shoji Seki, Yasuhito Yahara, Tomoatsu Kimura Poster No. 0480 miR-125b is associated with doxorubicin resistance in Ewing sarcoma Keiichiro Iida, Jun-ichi Fukushi, Yoshihiro Matsumoto, Toshifumi Fujiwara, Yuko Okada, Mihoko Koga, Akira Nabeshima, Yukihide Iwamoto Poster No. 0481 Flavokawain B Induces Apoptosis in Synovial Sarcoma Cell Lines Toshinori Sakai, Ramez Eskander, Yi Guo, Kap Jung Kim, Jason Mefford, Justin Hopkins, Nitin N Bhatia, Xiaolin Zi, Bang H Hoang Poster No. 0482 Circulating Biomarkers-IgM Complexes in the Serum of Pediatric Patients with Osteosarcoma and Ewing Tumor Yulia A Savitskaya, Genaro Rico, Luis Linares, Rene Tellez, Elisa Martinez, Garly Gonzalez, Clemente Ibarra Poster No. 0483 Macrophage infiltration predicts a poor prognosis for the human Ewing sarcoma Toshifumi Fujiwara, Jun-ichi Fukushi, Shunsaku Yamamoto, Yoshihiro Matsumoto, Nokitaka Setsu, Yoshinao Oda, Hisakata Yamada, Seiji Okada, Satoshi Kamura, Keiichiro Iida, Yuko Okada, Mihoko Koga, Yukihide Iwamoto 80 Poster No. 0484 Oncolytic adenovirus-mediated p53 gene transfer induces antitumor effect in human bone and soft tissue sarcoma cells Jo Hasei, Tuyoshi Sasaki, Hiroshi Tazawa, Yuuri Hashimoto, Toshiyuki Kunisada, Yasuo Urata, Toshifumi Ozaki, Toshiyoshi Fujiwara Poster No. 0485 Acidic extracellular pH and V-ATPase activity modulate cancer survival and stemness of Ewing’s sarcoma Sofia Avnet, Gemma Di Pompo, Francesca Perut, Manuela Salerno, Nicoletta Zini, Stefano Ferrari, Nicola Baldini Poster No. 0486 Forced expression of EWS-ATF1 induces soft tissue sarcomas Kazunari Yamada, Takatoshi Ohno, Yasuhiro Yamada, Akihito Nagano, Lori Takigami, Aya Matsuhashi, Mitsuru Saitou, Noritsugu Tsugita, Akira Hara, Katsuji Shimizu Poster No. 0487 Immune regulation of bone metastases: Role of T cells and Myeloid Derived Suppressor Cells in the tumor/bone vicious cycle Roberta Faccio, Aude-Helene Capietto Poster No. 0488 Electrochemotherapy in Experimental Bone Metastases Milena Fini, Veronica Borsari, Francesca Salamanna, Annapaola Parrilli, Lucia Martini, Michela Battista Poster No. 0489 Nephroblastoma overexpressed (NOV/CCN3) promotes prostate cancer-induced bone resorptive lesions thorough osteoclast formation by up-regulation of receptor activator of NF-κB (RANK) expression in myeloid precursor cells Po Chun Chen, Chih Hsin Tang, Hsu Chen Cheng, Yung Cheng Chiu Poster No. 0490 Breast Tumor Cells Alter Mesenchymal Stem Cell Differentiation Bryan S Margulies, Min Jeong Kim Poster No. 0491 Quantifying the mechanical behavior of mixed osteolytic/osteoblastic spinal metastases: A comparison of µCT based image registration and multimodal finite element modeling Seyed-Parsa Hojjat, Maarten Beek, Lisa Wise-Milestone, Margarete K Akens, Cari Whyne Poster No. 0492 Transcutaneous Application of CO2 Induced Mitochondrial Apoptosis in Human Malignant Fibrous Histiocytoma Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Masahiro Kurosaka, Toshihiro Akisue Poster No. 0493 Transcutaneous Application of CO2 Enhanced Radiosensitivity in Human Malignant Histiocytoma Cells in vivo Yasuo Onishi, Teruya Kawamoto, Takeshi Ueha, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Ryohei Sasaki, Masahiro Kurosaka, Toshihiro Akisue Poster No. 0494 Silencing of Decoy Receptor 3 Enhances FasL Induced Apoptosis and Decreases Migration and Invasion Ability in Human MFH Cells Mitsunori Toda, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Yasuo Onishi, Risa Harada, Masahiro Kurosaka, Toshihiro Akisue PS1 Bone Biology Poster No. 0496 Norepinephrine Transporter Blockade Reduces Bone Mass Accrual Yun Ma, Jeffry Nyman, Preston Campbell, Daniel Perrien, Xiangli Yang, Florent Elefteriou Poster No. 0497 Cycloxygenase-2 contributes to osteogenic-differentiation on murine bone marrow mesenchymal stem cells SHu-Chun Chuang, Ching-Ju Li, I-Chun Tai, Gwo-Jaw Wang, Je-Ken Chang, Mei Ling Ho Poster No. 0498 Osteoblast-specific Transcription Factor Osterix Increases Vitamin D Receptor Gene Expression in Osteoblasts Chi Zhang, Wanjin Tang, Yang Li, Fan Yang, Diane Dowd, Paul MacDonald Poster No. 0499 COMP Enhances BMP2-dependent Osteogenesis in C2C12 Cells via Activating BMP2 signaling Kazunari Ishida, Chitrangada Acharya, Jasper Yik, Paul E Di Cesare, Dominik R Haudenschild Poster No. 0500 The Importance of Sodium-Phosphate Co-Transport for Proper Bone Mineral Composition and Structure Adele L Boskey, Lyudmilla Lukashova, Lyudmila Spevak, Saeed R Khan Poster No. 0501 Osteoclast Specific Connexin 43 Deletion Results in Decreased in vivo Osteoclastogenesis Yue Zhang, Mitchell Sternlieb, Emmanuel Paul, Henry J Donahue Poster No. 0502 A Member of Sialic Acid-Binding Immunoglobulin-Like lectin 15 (Siglec-15) Associates with DAP12-mediated Costimulatory Signal in Osteoclastogenesis Miki Komatsu, Masahiko Takahata, Norimasa Iwasaki, Yusuke Kameda, Akio Minami Poster No. 0503 Indeno[1,2-c]quinoline Derivatives as Inhibitors of Osteoclastogenesis via NFAT Ruwei Lin, Gwo-Jaw Wang Poster No. 0504 A comparison of two osteoclast inhibitors in the Oim/oim Growing Mouse Model of Osteogenesis Imperfecta Cathleen L Raggio, Adele L Boskey, Nancy Pleshko, Josephine Marino, Erin Carter, Maria Baldino, Renee Bargman Poster No. 0505 Zoledronic Acid not only Inhibits Osteoclast Activity but also Enhances Mineralisation Orlaith Brennan, Julia S Kuliwaba, Ian H Parkinson, Nicola L Fazzalari, Laoise M McNamara, Fergal J O’Brien Poster No. 0506 WITHDRAWN Poster No. 0507 NFκB Activity is Elevated in Aging Bone, Uncouples Osteoblasts and Osteoclasts In Vivo and Mediates SIRT1 Regulation of Bone Cells James Edwards, Dan S Perrien, Koichiro Ono, Linda Connelly, Megan Weivoda, Seint Lwin, Jeffrey Nyman, Florent Elefteriou, Greg R Mundy Posters Poster No. 0495 Inhibition of induced autophagy increases apoptosis in Nara-H cells Osamu Nakamura, Toshiaki Hitora, Yoshiki Yamagami, Masaki Mori, Tetsuji Yamamoto Poster No. 0508 OC-STAMP and DC-STAMP are both essential for cell-cell fusion in osteoclasts and foreign body giant cells Hiroya Miyamoto, Hideo Morioka, Kazuhiro Chiba, Yoshiaki Toyama, Takeshi Miyamoto Poster No. 0509 Impaired bone formation in osteoblast-specific miR-214 transgenic mice during postnatal bone development Baosheng Guo, Xiaogang Wang, Heng Wu, Zhijun Yang, Leungkim Hung, Yinhui Li, Ling Qin, Ge Zhang, Yingxian Li Poster No. 0510 The Synergistic Effect of Osteocytes and Osteoblasts on the Osteogenic Differentiation of MSCs Evelyn Birmingham, Glen L Niebur, Laoise M McNamara, Peter E McHugh Poster No. 0511 Gain and Loss of Liver X Receptor Function Studies Suggest a Potential but Complex Role in Bone Andrew R Berry, Karen B King, Shum C Laura, Yupanqui Caldas, Hector Giral, Richard M Ackerson, Allan L Bucknell, Arturo Orellana, Carolyn L Cummins, Moshe Levi Poster No. 0512 Protective Effects of Human Osteoblast-like Cells to Apoptotic Threat of PK 11195, a Synthetic Translocator Protein 18 kDa (TSPO) Ligand Nahum Rosenberg Poster No. 0513 Increase in murine calvaria bone structure during prolonged exposure to microgravity Bing Zhang, Esther Cory, Roshmi Bhattacharya, Robert L Sah, Alan Hargens Poster No. 0514 The effect of STAT5A RNA interference inhibit osteogenesis of human mesenchymal stem cells Jisuk Hwang, Ho Sun Jung, Woo Jin Choi, Sung Hwan Kim, Jin Woo Lee Poster No. 0515 Bone Morphology Regulates Mineralization in Mice during Growth and Development Meghan E Faillace, Melissa Ramcharan, Karl Jepsen Poster No. 0516 Degree of Bone Mineralization in the Ultra Distal Radius as a Function of Type and Location David W Wagner, Derek Lindsey, Gary S Beaupre 81 Posters Poster No. 0517 Regulation on osteoblast proliferation and function by calcium sulphate/basalt fiber structures Xi Chen, Zhao-Li Liu, Hui-Lin Yang, Zong-Ping Luo Poster No. 0528 SDF-1 Regulates BMP2-Induced Osteo/Chondrogenic Differentiation in a Dose-Dependent Manner Gang Liang, Adele L Boskey, Wei Zhu Poster No. 0518 Primary cilia act as mechanosensors during bone healing around an implant Philipp Leucht, Stefanie Monica, Jie Jiang, Christopher R Jacobs, Robert Spilker, John B Brunski, Jill A Helms Poster No. 0529 Growth Factor with New Features: Development of Collagen Binding Domain BMP4 Tetsuro Mazaki, Yasuyuki Shiozaki, Aki Yoshida, Mariko Nakamura, Yasuhiro Yoshida, Takashi Kitajima, Yoshihiro Ito, Masato Tanaka, Akihiro Matsukawa, Toshifumi Ozaki Poster No. 0519 Automatic Extraction and Analysis of Calcium Signaling in Bone Cell Network Da Jing, PuiLeng Leong, Victor Chiang, Paul Sajda, X. Edward Guo Poster No. 0520 Chronic Alcohol Consumption is Associated with Subtle Alterations in Femoral Transcriptomic, Compositional, and Morphometric Phenotype in Male Rhesus Macaques Mandi J Lopez, Clifford Les, P. Brommala, Carola L Pechey, M. Haque, N. LeCapitaine, S. Nelson, G. Bagby, J. Dufour, Patricia E Molina Poster No. 0531 BMP2-eNOS Axis Controls Normal Skeletal Development and StatinInduced Bone Formation James Edwards, Megan Weivoda, Ming Zhao, Seint T Lwin, I. R Garrett, Gloria Gutierrez, Greg Mundy Poster No. 0521 Revision Reasons and Bone Ingrowth in Retrieved Porous Tantalum Tibial Trays and Patellas Josa A Hanzlik, Judd S Day, Gregg Klein, Harlan Levine, Mark Hartzband, Javad Parvizi, Matthew J Kraay, Clare M Rimnac, Steven M Kurtz Poster No. 0532 p53 and ROS mediate the deleterious effects of TNFα on osteoblast differentiation and proliferation Nicole Fleming, Vanessa Bray, Decorian M Williams, Christine M Eischen, Daniel S Perrien Poster No. 0522 Seasonal and Anatomic Variation in Compact Bone Remodeling in the Adult Sheep Joseph C Calcagno, Scott Hazelwood, Carola L Pechey, Elisabeth M Steel, Jennifer M Macleay, Anthony S Turner, Clifford Les Poster No. 0533 A -238 Tumor Necrosis Factor Promoter Polymorphism that Associates with Periprosthetic Osteolysis Interacts with the Thyroid Hormone Receptor to Modulate TLR-Induced TNF Expression J. Mark Wilkinson, Edward Harlock, Endre Kiss-Toth Poster No. 0523 Mechanically-induced Signaling Events in the Skeleton After In-Vivo Bone Loading Jason A Bleedorn, Troy Hornberger, Zhengling Hao, Susannah J Sample, Peter Muir Poster No. 0534 Stromal derived factor-1 stimulates cell recruitment and vascularization in an ectopic bone forming model Rhandy M Eman, Cumhur F Oner, Wouter J Dhert, Jacqueline Alblas Poster No. 0524 Does Trabecular Bone Have the Capacity to Adapt at the Material/ Compositional Level? Alex N Knight, John G Skedros, Ryan W Farnsworth, Brooke S Kawaguchi, Roy D Bloebaum Poster No. 0525 Collagen Fiber Orientation (CFO) and CFO Heterogeneity (CFOHet) in the Human Femoral Neck Cortex: Do these Characteristics Demonstrate Age-Related Changes in Load-History? Kendra E Keenan, John G Skedros Poster No. 0526 Analysing the internal topography of bone via three dimensional study of bone island dimensions and Alan Parish, Graham Davis, Karin Hing PS1 Bone - Growth Factors Poster No. 0527 Deficiency of Growth Differentiation Factor 5 (GDF-5) Inhibits Bone Formation after Femoral Bone Marrow Ablation Vbenosawemwinghaye Orhue, Siddhesh R Angle, David G Karwo, Dale R Sumner, Amarjit S Virdi, Kotaro Sena 82 Poster No. 0530 Plasma Factor XIII Accelerates Bone Formation in the Treatment of Bone Defects Lutz Claes, Johanna Lieb, Anita Ignatius Poster No. 0535 Connective Tissue Growth Factor (CTGF/CCN2) is Required for Normal Intramembranous and Endochondral Ossification Alex G Lambi, Talia L Pankratz, Honey Hendesi, Robin A Pixley, Mary F Barbe, Joan T Richtsmeier, Steven N Popoff Poster No. 0536 The importance of the GH/IGF-I axis for macroscopic and microscopic murine bone morphometry Philipp Schneider, Romain Voide, Marco Stampanoni, Leah Rae Donahue, Ralph Müller PS1 Bone - Osteoporosis & Metabolic Bone Disease Poster No. 0537 Effects of Parathyroid Hormone Treatment in Ovariectomized Rats Lamya Karim, Julie Campbell, Steven Tommasini, Stefan Judex, Deepak Vashishth Poster No. 0538 Osteogenic effects of black bear PTH (1-84) in a mouse model of Duchenne muscular dystrophy Sarah Gray, Meghan McGee-Lawrence, Seth Donahue Poster No. 0550 Effects of gelatin-strontium substituted calcium phosphate unidirectional scaffold for osteoporosis application Shih-Ping Yang, Wan-Ching Chou, Wei-Yu Lin, Chih-Han Chang, Da-Jun Lin, Truan-Sheng Lui, Chyun-Yu Yang, Tzer-Min Lee Poster No. 0540 The Relationship Between Material Stiffness and Fracture Toughness in Ovine Compact Bone at High Displacement Rates is Lost with OVX and is Rescued with Estrogen Replacement Elisabeth M Steel, Carola L Pechey, Dana Ruehlman, Jennifer M MacLeay, Anthony S Turner, David P Fyhrie, Yener Yeni, Clifford Les Poster No. 0551 Site-Specific Changes in Bone Microarchitecture, Mineralization, and Stiffness during Lactation and after Weaning in Mice X. Sherry Liu, Laleh Ardeshirpour, Joshua VanHouten, Elizabeth Shane, John J Wysolmerski Poster No. 0541 Apoptosis and Mineralization of Osteocytes following Estrogen Withdrawal Meadhbh Brennan, Fergal J O’Brien, Laoise M McNamara Poster No. 0542 Correlations between elastic and viscoelastic properties of estrogen deficient bone tissue Do-Gyoon Kim, Sarandeep S Huja, Andrew D’Atri, Anand Navalgund, BoonChing Tee, Nari Kim Poster No. 0543 The Effects of Estrogen Loss on the Vascular Porosity in Rat Cortical Bone Jessica Levy, Divya Sharma, Stephen Doty, Susannah Fritton Poster No. 0544 Intraperitoneal injection of (-)-epigallocatechin-3-gallate (EGCG) increases osteogenesis in ovariectomized rats Jian-Chih Chen, Ru-Wei Lin, Rita Santos Wu, Yi-Shan Lin, Mei-Ling Ho, Je-ken Chang, Shao-Hung Hung, Yin-Chih Fu, Gwo-Jaw Wang, ChungHwan Chen Poster No. 0545 Preliminary Results: Initiation of Rank-Fc Treatment in PostAdolescent Oim/oim Mice Does Not Reduce Fracture Incidence Josephine Marino, Erin Carter, Maria Baldino, Adele L Boskey, Nancy Pleshko, Cathleen L Raggio Poster No. 0546 Elevated RANKL and Runx2 Expressions by Titanium-Debris Challenged Osteoblasts Are Associated with Osteoclast Maturation Shang-You Yang, Zheng Song, Tala Sandid, Minyan Fan, Paul H Wooley Posters Poster No. 0539 The Synergistic Effect of Teriparatide and Electrical Stimulation on Improving Vertebral Body Bone Mineral Density in Osteoporotic Rabbits Hallie Murray, Paul D’Antonio, Douglas C Fredericks, Joseph Smucker Poster No. 0552 Bone loss and structural changes in a sickle cell disease mouse model Richard Smith, Hannah Shackelford, T. Pestina, D. Persons, Kent Gartner Poster No. 0553 Significant Distal Phalangeal Bone Loss in Equine Laminitis Julie B Engiles, Hannah Galantino-Homer, Michael Dishowitz, Diane McDonald, Raymond Boston, Kurt D Hankenson Poster No. 0554 Prediction of Trabecular Structural Orientation by Noninvasive Quantitative Ultrasound with Correlation to µCT Liangjun Lin, Chris Lin, Jiqi Cheng, Yi-Xian Qin PS1 Progenitors & Stem Cells Poster No. 0555 Isolation and Characterization of Human Amniotic Mesenchymal Stem Cells and Their Chondrogenic Differentiation Makiko Nogami, Hiroaki Tsuno, Chika Koike, Motonori Okabe, Toshiko Yoshida, Shoji Seki, Yoshito Matsui, Toshio Nikaido, Tomoatsu Kimura Poster No. 0556 Regulation of Chondrogenesis in Mesenchymal Stem Cells Derived from Embryonic Stem Cells is Associated with Growth Factor Receptor Expression Patrick T Brown, Igor I Slukvin, Matthew W Squire, Wan-Ju Li Poster No. 0557 Inhibition of β-catenin Enhances Mesenchymal Stem Cell Chondrogenesis Lauren Y Statman, Juan M Taboas, Tamara Alliston, Rocky S Tuan Poster No. 0547 Effect of Zoledronic Acid on Trabecular Bone of an Ovine Model of Osteopenia at Multiple Skeletal Sites Ignacio J Garcia, Jayme C Burcket, Jennifer MacLeay, Ericka Calton, Marjolein van der Meulen, Adele L Boskey Poster No. 0558 Collagen Type I as Scaffold Biomaterial Decreases TGF-β-induced MMP-10 Synthesis of Human Mesenchymal Stromal Cells (MSC): Model of Cartilage Construct Degeneration Melanie L Hart, Katrin Warstat, Falk Mittag, Tino Felka, Torsten Kluba, Bernd Rolauffs, Wilhelm K Aicher Poster No. 0548 The Effects of Age on Changes in the Densitometric and Mechanical Properties in the Femur of the Hindlimb Unloaded Adult Rat Derrick S Morgan, Joshua Davis, Joshua Kupke, Yasaman Shirazi-fard, Susan Bloomfield, Harry Hogan Poster No. 0559 Characterization of a fluorescence/luminescence reporter construct for extended evaluation of chondrogenesis in vitro and in vivo Ryan M Porter, Fangjun Liu, Elizabete Ferreira, Christopher Evans Poster No. 0549 How Does Bone Augmentation Improve Primary Implant Stability? Juri A Steiner, Christoph Wenger, Thomas L Müller, Davide Ruffoni, Müller Ralph, Harry van Lenthe Poster No. 0560 Variations in Gene Expression of MSCs during Chondrogenic Differentiation in Fibrin/Alginate Blended Gels Kun Ma, Marc E Levenston 83 Posters Poster No. 0561 Co-culture with human mesenchymal stem cells protects juvenile chondrocytes against cytokine-induced upregulation of MMP-13 Margaret E Cooke, Jeffrey C Lotz, Tamara Alliston Poster No. 0562 Optimizing Human Adipose Stem Cells as Trophic Factor Sources for Cartilage Regeneration Christopher Lee, Elyse A Watkins, Olivia A Burnsed, Joseph K Williams, Zvi Schwartz, Barbara D Boyan Poster No. 0563 Response of Adipose-Derived Stem Cells to Dynamic Compression During In Vitro Chondrogenesis Chun hua Zheng, Melissa Stafford, Marc E Levenston Poster No. 0564 Phenol Red Inhibits Chondrogenic Differentiation of Human Mesenchymal Stem Cells In Vitro Helle Lysdahl, Anette Baatrup, Anna B Nielsen, Casper B Foldager, Cody E Bünger Poster No. 0565 Quantitative Comparison of Periosteum- and Bone Marrow-Derived Human Multipotent Cell Populations and Their Differentiation Potentials Hana Chang, Tzvetan Popov, Denitsa Docheva, Stefan Milz, Matthias Schieker, Melissa L Knothe Tate Poster No. 0566 Expression of Insulin-like Growth Factor Type 1 Receptor and Myosin Heavy Chain in Rabbit’s Rotator Cuff after Rotator Cuff Repair and Injection of Adipose-derived Stem Cell Sae Hoon Kim, Joo Han Oh, Jin Young Chung, Ws Lim, Seung Han Shin, Seok Won Chung, Yeun Ho Kim, Byung Wook Song, Ji Wook Choi Poster No. 0567 Single Pulsed Electromagnetic Field Rearrange the Cytoskeleton Organization of Human Bone Marrow Derived Mesenchymal Stem Cells Chih Chun Lin, Yang Kao Wang, Gwo Jaw Wang, Kao Chi Chung, Guo An Lai Poster No. 0568 A novel gravitational marrow separator to isolate bone marrow mesenchymal stem cells Akikazu Ishihara, Holly Helbig, Rebekah Sanchez-Hodge, Maxey Wellman, Alicia Bertone Poster No. 0569 Exogenous adiponectin increases proliferation and differentiation rate of tenocyte progenitor cells in serum free cell culture Tunku Kamarul, Hussain A Rothan, Murali Malliga Raman Poster No. 0570 Characterization of Tendon Stem/Progenitor Cells in Tendon Tissue in vivo Qi Tan, Yunfeng Rui, Pauline Po Yee Lui Poster No. 0571 Engineered Tendon Matrix Promotes the Stemness of Tendon Stem Cells Jianying Zhang, James H Wang 84 Poster No. 0572 Mesenchymal stem cell gene expression changes with exposure to tendon extracellular matrix and tenocytes but not towards a tenogenic or chondrogenic phenotype Margaret M Smith, Varshini Ravi, Stephen N Hunyer, Christopher Ward, Marie-Christine Morel-Kopp, Christopher B Little Poster No. 0573 Local Transplantation of Ex-vivo Expanded Bone Marrow-derived CD34 Positive Progenitor Cells Accelerate non-Union Fracture Healing Yohei Kawakami, Masaaki Ii, Tomoyuki Matsumoto, Atsuhiko Kawamoto, Taro Shoji, Yutaka Mifune, Tomoaki Fukui, Ryosuke Kuroda, Masahiro Kurosaka, Takayuki Asahara Poster No. 0574 Femoral Bone Marrow Ablation Induces Stem Cell Mobilization in the Mouse Margaret A McNulty, Kent W Christopherson, Kotaro Sena, Amarjit S Virdi, Dale R Sumner Poster No. 0575 Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing expression of osteogenetic markers in a cloned bone marrow mesenchymal stem cell Xinlin Yang, Hongjian Liu, Yi Zhang, Abhijit S Dighe, Xudong Li, Quanjun Cui Poster No. 0576 Osteogenesis- and Pluripotency-related Genes have Inverse Effects on Stemness of Human Bone Marrow-derived Mesenchymal Stem Cells Dong Suk Yoon, Yun Hee Kim, Sung Hwan Kim, Jin Woo Lee Poster No. 0577 The host immune response to allogeneic and syngeneic stem cells modulates osteogenesis Vedavathi Madhu, Scott Yang, Abhijit S Dighe, Gary Balian, Quanjun Cui Poster No. 0578 BMPs are ineffective in vitro but enhance MSCs-induced osteogenesis in vivo Vedavathi Madhu, Abhijit S Dighe, Ching Ju Li, Gary Balian, Quanjun Cui Poster No. 0579 Phosphoproteomic analysis of human mesenchymal stromal cells during osteogenic differentiation Ting Lo, Chia-Feng Tsai, YuRu V Shih, Yi-Ting Wang, Sheng-Chieh Lu, Ting-Yi Sung, Wen-Lian Hsu, Yu-Ju Chen, Oscar K Lee Poster No. 0580 Autophagy activity does not decline in accelerated-aging mice model as it does in normal aging mice Xiaodong Mu, Koji Takayama, Kurt R Weiss, Johnny Huard Poster No. 0581 BMP4 Induction of MSC Adipogenesis is Blocked by RA Downregulation of SMAD/P38 Jeong Soon Lee, Jin-Hee Park, Ligyeom Ha, Jung Yul Lim Poster No. 0582 The Regulation of Adipogenesis in the Visceral and Marrow Fat Compartments by SHIP1 Bryan S Margulies, Sean D DeBoyace, Connor G Policastro, Christopher E Storey, Sonia Iyer, William G Kerr Poster No. 0584 WITHDRAWN Poster No. 0585 Culture Condition Optimization of Human Anterior Cruciate Ligament- and Bone Marrow-Derived Stem Cells for Ligament Tissue Engineering Ming-Te Cheng, Chien-Lin Liu, Oscar Lee, Tain-Hsiung Chen Poster No. 0586 Optimization of bone regeneration and repair using human musclederived stem cells Xueqin Gao, Arvydas Usas, Aiping Lu, Ying Tang, Jessica C Tebbets, Bing Wang, James H Cummins, Johnny Huard Poster No. 0587 Muscle-Derived Stem Cells from a Murine Model of Accelerated Aging Shows Limited Osteogenic Potential Sahnghoon Lee, Mitra Lavasani, Hongshuai Li, Xueqin Gao, Satoshi Terada, Koji Takayama, Laura Niedernhofer, Freddie H Fu, Johnny Huard Poster No. 0588 mTOR Modulates Proliferation of Muscle-Derived Stem Cells from Progeroid (ERCC1-/Δ) mouse Koji Takayama, Xiaodong Mu, Mitra Lavasani, Satoshi Terada, Sahnghoon Lee, Arvydas Usas, Burhan Gharaibeh, Laura J Niedernhofer, Freddie H Fu, Johnny Huard Poster No. 0594 Environmental sensitivity of Fibronectin adsorption to Stoichiometric and Silicate Substituted Hydroxyapatite bone graft substitutes Viviana Castagna Poster No. 0595 A New Evaluation System of Beta-Tricalcium Phosphate Resorbability in Opening Wedge High Tibial Osteotomy Takaaki Tanaka, Yoshio Kumagae, Masaaki Chazono, Seiichiro Kitasato, Atsuhito Kakuta, Keishi Marumo Poster No. 0596 In vitro Evaluation of Sequential Delivery of BMP-2 and IGF-1 for Osteoblastic Differentiation using a Chitosan Gel with Gelatin Microspheres Sungwoo Kim, Yunqing Kang, Won-Shik Chu, Yunzhi Yang Poster No. 0597 Is Bone Formation by Silicon-Substituted Calcium Phosphates Affected by Materials Rate of Resorption? Sorousheh Samizadeh, Karin Hing, Tom Buckland, Melanie Coathup, Gordon W Blunn Poster No. 0598 Solid-Freeform-Fabricated Porous Calcium Polyphosphate Structures for Bone Substitute Uses Yaser Shanjani, Youxin Hu, Robert M Pilliar, Marc Grynpas, Rita Kandel, Ehsan Toyserkani Poster No. 0599 Osteoblast Function is improved on a Phosphonic Acid Containing Synthetic Bone Graft Substitute Anita K Bassi, Julie E Gough, Sandra Downes Poster No. 0589 Defective Proliferation and Myogenic Differentiation potential of Muscle-Derived Stem Cells Isolated from Dystrophin/Utrophin-/- mice Aiping Lu, Jonatnan Proto, Ying Tang, Minakshi Poddar, Bing Wang, Johnny Huard Poster No. 0600 In vivo evaluation of calcium phosphate bone void fillers in a rabbit single-level posterolateral fusion model William R Walsh, William Lloyd, Brian M Schlossberg, Yan Yu, Rema Oliver, Chris Cristou, Edward S Ahn Poster No. 0590 Contribution of endogenous endothelial progenitor cells to neovascularization and astrogliosis in spinal cord injury Naosuke Kamei, Masakazu Ishikawa, Takayuki Asahara, Mitsuo Ochi Poster No. 0601 Evaluations of a Novel Hemiporous Hydroxyapatite Scaffold as a Cell-mediated Bone Substitute Sang-Min Seo, Dong-Min Kim, Tai-Joo Chung, Kyung-Sik Oh, Ha Na Kim, Jinwoo Nam, Hee Joong Kim, Jeong Joon Yoo Poster No. 0591 Annulus Fibrosus-derived Stem Cells: Isolation and Characterization Qianping Guo, Xuebin Tang, Huilin Yang, Bin Li PS1 Biomaterials - Bioactive Poster No. 0592 Novel Surface Modified PLGA Microspheres to Modulate Drug Release Kinetics Jun Wu, Michael To, Kelvin Yeung Poster No. 0593 Enhanced Bone Formation using a Phosphonic Acid Containing Synthetic Bone Graft Substitute Anita K Bassi, Julie E Gough, Sandra Downes Posters Poster No. 0583 Myogenic Differentiation Dysfunctions on Muscle-derived Stem Cells Isolated from Mouse Model of Progeria Minjung Song, Mitra Lavasani, Seth, David Thompson, Aiping Lu, Johnny Huard Poster No. 0602 Effect of Fiber Diameter on a Porous Bioactive Glass Scaffold Janet L Krevolin, James J Liu, Vincent Valant Poster No. 0603 In vitro evaluation of novel magnetic Fe-Hydroxyapatite nanoparticles for bone applications Silvia Panseri, Teresa D’Alessandro, Monica Sandri, Nora Khanarian, Helen Lu, Maurilio Marcacci, Anna Tampieri, Clark T Hung Poster No. 0604 In-Vivo Evaluation of Human Mesenchymal Stem Cells Survival in a Large Segmental Bone Defect in Mice Mathieu Manassero, Véronique Viateau, Jose Retortillo, Mickael Deschepper, Morad Bensidhoum, Delphine Logeart-Avramoglou, Hervé Petite 85 Posters Poster No. 0605 Osteointegration enhancement by human BMSCs and biofactor enriched hydrogels in Trabecular Titanium implants Silvia Lopa, Arianna Barbara Lovati, Giuseppe Talò, David Mercuri, Francesco Segatti, Luigi Zagra, Matteo Moretti Poster No. 0606 Scaffold Mechanical Properties Influence the Hypertrophic Differentiation of Chondrogenically-induced Human Mesenchymal Stem Cells Liming Bian, Emily C Zhang, Robert L Mauck, Jason Burdick Poster No. 0607 Efficient Optimization of Orthopedic Device Coatings for Non-viral Stem Cell Transfection Siyoung Choi, William Murphy Poster No. 0608 Crosslinking of Scaffolds Produced from Cartilage-Derived Matrix Prevents Cell-Mediated Contraction and Alters the Chondrogenic Induction of Mesenchymal Stem Cells Christopher R Rowland, Donald P Lennon, Arnold I Caplan, Farshid Guilak Poster No. 0609 Mesenchymal Stem Cells and Extracellular Cartilage Matrix-derived Scaffolds for Cartilage Defect Repair Kim Benders, Willemijn Boot, Rene Van Weeren, Daniel Saris, Wouter Dhert, Jos Malda Poster No. 0610 Human Mesenchymal Stem Cells Upregulate Gene Expression of Cartilaginous ECM when Encapsulated in Desulfated Chondroitin Hydrogels in the Presence of TGF-β1 Jeremy J Lim, Rachel H Van Stelle, Johnna S Temenoff Poster No. 0611 Attenuated BMP-2 Mediated Bone Regeneration in a Rat Model of Composite Bone and Muscle Injury Nick J Willett, Mon-Tzu A Li, Brent A Uhrig, Joel D Boerckel, Gordon Warren, Robert E Guldberg Poster No. 0612 Competitive Assessment of Polymer-based Bone Scaffolds and Mineralized Cancellous Allograft in the Canine Femoral Multi-Defect model Kentaro Shinohara, Viviane Luanghakdy, Hui Pan, Theresa Hefferan, Linda Griffith, Michael Yaszemski, Jachim Kohn, George Muschler Poster No. 0613 Regeneration of a Critical-Size Femur Defect using Keratin Biomaterial Carrier with BMP-2 Roche de Guzman, Michelle Merrill, Justin Saul, Mary Ellenburg, Thomas Smith, Mark Van Dyke Poster No. 0614 Increased Bone Formation in a Porcine Critical Size Defect when using Hyaluronic Acid and TCP Coated Polycaprolactone Scaffolds Seeded with Autologous Dental Pulp Stem Cells Jonas Jensen, Claus Tvedesøe, Muwan Chen, David C Kraft, Jens V Nygaard, Asger A Kristiansen, Jørgen Baas, Cody Bünger 86 Poster No. 0615 Developmental of Collagen Binding Domain BMP4 in Rabbits Bone Defects Aki Yoshida, Yasuyuki Shiozaki, Tetsuro Mazaki, Akihiro Matsukawa, Yasuhiro Yoshida, Mariko Nakamura, Takashi Kitajima, Toshifumi Ozaki Poster No. 0616 Injectable Recombinant Human Lactoferrin Gel as a Bioactive Material for Bone Regeneration Ashley Amini, Lakshmi Nair Poster No. 0617 Creation of Core-Sheath PLA Nanofibers Doped With Tricalcium Phosphate as a Controlled Release System for Bone Tissue Engineering Applications Mahsa Mohiti Asli, Behnam Pourdeyhimi, Elizabeth G Loboa Poster No. 0618 Optimizing In Vivo Bone Tissue Engineering: Local Co-Delivery of rhBMP-2/Zoledronic Acid Nicole Y Yu, Aaron Schindeler, Kathy Mikulec, Lauren Peacock, Jane Fitzpatrick, Justin J Cooper-White, Andrew Ruys, David G Little Poster No. 0619 Nanofibrous Synthetic/Biologic Composites as Multifunctional and Dynamic Growth Factor Delivery Systems Jonathan A Kluge, Rudra A Pampati, Daniel J Zhou, Mara L Schenker, Feini Qu, John Esterhai, David L Kaplan, Robert L Mauck Poster No. 0620 Activation of Polyurethane Scaffolds by Surface Treatment with Diamines and Heparin Eric de Mulder, Dennis Löwik, Martin Koens, Gerjon Hannink, Nico Verdonschot, Pieter Buma Poster No. 0621 Synthesis, Characterization of Calcium Phosphates/Polyurethane Composites for Weight Bearing Implants Toshitaka Yoshii, Jerald E Dumas, Shinichi Sotome, Atsushi Okawa, Scott A Guelcher Poster No. 0622 Species-Specific Collagen Deposition in Tissue-engineered Bone and Cartilage: A Xenograft Model of the Human Digit Russell J Fernandes, MaryAnn Weis, Yoshitaka Wada, Robin Jacquet, Elizabeth Lowder, Noritaka Isogai, David R Eyre, William Landis Poster No. 0623 Mechanical changes and hydrogen release of Mg-Sr, Mg-Sr-Ca and Mg-Sr-Zn during degradation in vitro and in vivo Xinhui Xie, Xuenan Gu, Jian Tang, Yufeng Zheng, Ling Qin Poster No. 0624 Biodegradable magnesium implants for pediatric trauma surgery Karin Pichler, Tanja Kraus, Stefan F Fischerauer, Isabell Gerber, Eva E Fischerauer, Elisabeth Martinelli, Peter J Uggowitzer, Annelie M Weinberg Poster No. 0635 Enhanced osteogenic activity in osteoblasts on a “bone-like” nanofibrous (PVA-Col-HA) matrix Wei Song, David Markel, Guangzhao Mao, Weiping Ren Poster No. 0626 Biological study of novel biodegradable polycaprolactonemagnesium hybrid scaffold for orthopaedic applications Hoi Man Wong, Kelvin Yeung, Paul Chu, Keith Luk, Kenneth Cheung Poster No. 0636 Substrate Thickness Modulates Electric Field-induced Ligament Fibroblast Migration Yu-Chen Cheng, Chia-Hsiang Feng, Pen-hsiu Grace Chao Poster No. 0627 Wrapped and Coated Cylindrical Mg Alloy Successfully Repaired Critical Size Bone Defect Xingguo Cheng, Todd L Bredbenner, Sapna Desai Poster No. 0637 Electrospun Wavy Fibers Modulate Loading-Induced Cell Alignment Hsiang-Yi Hsu, Chun-Yuan Liu, Pen-hsiu Grace Chao Poster No. 0628 Physiochemical Dual Action Bone-like Scaffold - Pilot Study in Canine Model Daniel S Oh, Francis Y Lee, Anny Hsu, Hanying Bai, Saqib Nizami, Hana Goto, Hesham Tawfeek, Jongmin Kim, Seokhwa Choi Poster No. 0629 The Effect of Processing Conditions of the Osteoinductivity of Sheep Demineralized Bone Matrix in an Ectopic Nude Rat Model: A Pilot Study Nicholas Russell, Vedran Lovric, Rema Oliver, Matthew Pelletier, Yan Yu, William R Walsh Poster No. 0630 PLGA/TCP scaffolds incorporating phytoestrogenic molecule icaritin developed for bone defect repair Shihui chen, Ming Lei, Ge Zhang, Lizhen Zheng, Wei Li, Zhe Zhao, Xinluan Wang, Xinhui Xie, Xiaohong Wang, Deming Xiao, Daping Wang, Ling Qin Poster No. 0631 A Natural Granular Resorbable Scaffold for Bone Regeneration in Sheep Mathieu Manassero, Véronique Viateau, Rosario Vallefuoco, Karim Oudina, Myrtil Valentin, Hervé Petite, Morad Bensidhoum Poster No. 0632 Osteochondral Repair using Bioabsorbable Cotton-Like Polymer Scaffold Ryosuke Sakata, Takeshi Kokubu, Issei Nagura, Yutaka Mifune, Hanako Nishimoto, Tomoyuki Muto, Hiroaki Kaneko, Makoto Satake, Hiroyuki Fujioka, Masahiro Kurosaka Poster No. 0633 The effectiveness of UV-irradiation for osteoblast-like cell adhesion to poly-ether-ether-ketone surfaces Yukimasa Okada, Nobuhiro Abe, Takayuki Furumatsu, Shinichi Miyazawa, Yusuke Yokoyama, Naoki Takada, Reina Tanaka, Hiroyuki Takahashi, Kunihiko Fujiwara, Hiroomi Kimura, Toshifumi Ozaki Poster No. 0634 VEGF Delivery from Electrospun Composites Increases Vascular Density In Vivo Lara Ionescu, Matthew Fisher, Mara L Schenker, John Esterhai, Robert L Mauck Posters Poster No. 0625 A Core/Shell Controlled Growth Factor Release System Potentiated the Osteoinductive Bioactivity of rhBMP-2 Sunny-Akogwu Abbah, James Goh, Hee-Kit Wong Poster No. 0638 A Comparison of Fibronectin and RGD Peptide Coatings for Improving Dermal Fibroblast Attachment to Intraosseous Transcutaneous Amputation Prostheses In Vitro Robert Dowling, Catherine Pendegrass, Gordon Blunn Poster No. 0639 Efficacy of Salicylic Acid-Based Poly(Anhydride-Ester) Scaffolds in a Rabbit Trephine Defect Model Ashley Mitchell, Sabrina Snyder, Kathryn E Uhrich, Patrick O’Connor Poster No. 0640 The variability of commercially available scaffolds in promoting osteogenesis in vitro Wellington K Hsu, Jason H Ghodasra, Michael Nickoli, David Nelson, Samuel I Stupp, Erin L Hsu Poster No. 0641 Immuno-Protective and Immuno-Suppressive Behavior Displayed by a Novel Viable Cell Bone Matrix Hallie Murray, Shyam Patel, Carl Javier, Paul D’Antonio, Michael Ponticiello, Pranela Rameshwar Poster No. 0642 Tunable Protein Delivery from Biodegradable Nanolayer Assemblies for Orthopaedic Applications Michael Keeney, Fan Yang Poster No. 0643 Effect of Addition of high Dose Antibiotics on the Mechanical Properties of Bone Cement: A Preliminary Study Mrinal Musib, Westley Hayes, Kirti Chakote, Vijay Rasquinha, Subrata Saha PS1 Tissue Engineering - Soft Tissue Poster No. 0644 Modification of PLGA Mesh Scaffold using Platelet-rich Plasma Pretreatment Techniques Jeong Joon Yoo, Ha Na Kim, Jinwoo Nam, Hee Joong Kim Poster No. 0645 Magnetic Alignment of Type I Collagen as a Method for Altering Compressive Mechanical Properties Tyler A Novak, Sherry Voytik-Harbin, Corey P Neu Poster No. 0646 The Degradation of Electrospun Polydioxanone Scaffold Patches Simon Hislop, Osnat Hakimi, Kalin Dragnevski, Stan Ng, Andrew Carr 87 Posters Poster No. 0647 Designing Electrospun Scaffolds with Architectures Suitable for Tendon Repair Lucy A Bosworth, Sandra Downes Poster No. 0648 Fabrication of rhCollagen Scaffold and Modulating its Elasticity for Soft and Hard Tissue Repair Racheli Gueta, Sigal Roth, Tamar Harel Adar, Shani Shilo, Shani Shilo, Oded Shoseyov Poster No. 0649 Multilayered Electrospun Scaffolds Produced from Cartilage-Derived Matrix for Cartilage Tissue Engineering N. W Garrigues, Dianne Little, Farshid Guilak Poster No. 0650 Using 3D Electrospun Nanofibrous Scaffolds to Repair Tendons Lucy A Bosworth, Jason Wong, Sarah H Cartmell, Duncan A McGrouther, Sandra Downes Poster No. 0651 Effect of Polymeric Nanofiber Scaffold Composition on ACL Fibroblast Response Siddarth D Subramony, Amanda Su, William N Levine, Helen Lu Poster No. 0652 Regeneration of ligamentous tissue by using a stent like shaped poly-L-lactide scaffold Hanako Nishimoto, Takeshi Kokubu, Atsuyuki Inui, Issei Nagura, Yutaka Mifune, Ryosuke Sakata, Tomoyuki Muto, Masahiro Kurosaka, Chiaki Hiwa, Kumiko Yokota, Hiroyuki Fujioka Poster No. 0653 Intra-Operative Patient Specific Functional Scaffold Fabrication Michael Liebschner, Kwonsoo Chun, Bruce Ehni Poster No. 0654 Dynamic Nanofibrous Scaffolds Improve In Vivo Colonization and Implant Fixation in a Meniscus Defect Model Mara L Schenker, Kevin Huang, Alvaro Bonilla, Matthew Fisher, Roshan P Shah, Lara Ionescu, Feini Qu, John L Esterhai, Thomas P Schaer, Robert L Mauck 88 Poster No. 0657 A Model for Testing the Effects of Injury and Repair Using Engineered Cartilage Tissue Analogs: The Effects of Impact Loading on Chondrocyte Gene Expression Wyatt C Strutz, Bhavana Mohanraj, Robert L Mauck, George R Dodge Poster No. 0658 Importance of composition and collagen organization for postimplantation mechanical performance in tissue-engineered cartilage implants Mehdi Khoshgoftar, Corrinus C van Donkelaar, Wouter Wilson, Keita Ito Poster No. 0659 Strategies for Enhancing Engineered Cartilage Properties using Adult Cells: Cell Seeding Density and Coculture with SynoviumDerived Stem Cells Elena Alegre-Aguarón, Andrea R Tan, Amy X Mei, James L Cook, Gerard A Athesian, Clark T Hung Poster No. 0660 Verification of a Novel Technique for Online Characterization of Cartilaginous Tissue in Bioreactor Christopher M Scanlon, Tai-Yi Yuan, Christina Echagarruga, Chun-Yuh C Huang, Wei Yong Gu Poster No. 0661 The Role of Environmental Factors in Regulating the Development of Cartilaginous Tissues Engineered using Osteoarthritic Human Infrapatellar Fat Pad Derived Stem Cells Yurong Liu, Conor T Buckley, Richard Downey, Kevin Mulhall, Daniel J Kelly Poster No. 0662 PLCL Scaffolds Enhanced with PHBV Microspheres as Novel Functional Biomaterials for Cartilage Regeneration Zigang Ge, Chao Li Poster No. 0663 Human Chondrocyte Response Cultured on Pre-treated PLGA Mesh Scaffold using Platelet-rich Plasma Jeong Joon Yoo, Ha Na Kim, Jinwoo Nam, Hee Joong Kim Poster No. 0664 Matrix-Associated Autologous Chondrocyte Transplantation in an Osteoarthritic Stifle Joint Martina Schinhan, Martina Gruber, Ronald Dorotka, Nicole Roessler, Stefan Nehrer Poster No. 0655 Effects of Mechanical Stimulation on Tenocyte Morphology and Gene Expression in Electrospun Collagen Scaffolds Alice Chou, Subhash Juneja, Tony Chen, Gino Bradica, Yiquan Wu, Robert Clark, Danielle Benoit, Hani A Awad Poster No. 0665 Engineering Cartilage Grafts using Fibrin Hydrogels Seeded with Diseased Human Infrapatellar Fat Pad Derived Stem Cells Conor T Buckley, Mark Ahearne, Richard Downey, Kevin J Mulhall, Daniel J Kelly Poster No. 0656 Controlled multiple growth factor delivery from bone tissue engineering scaffolds Darilis Suarez-Gonzalez, Alisha Diggs, Jae Sung Lee, Scott J Hollister, William L Murphy Poster No. 0666 Effects of One-sided Nutrient Supply and Air Exposure on MSC Chondrogenesis Kun Ma, Christopher L Lin, Clarissa S Gutierrez, Marc E Levenston Poster No. 0678 Effects of suture choice on biomechanics and physeal status after bio-enhanced ACL repair in skeletally immature patients - a large animal study Patrick Vavken, Braden C Fleming, Jason T Machan, Martha M Murray Poster No. 0668 Effect of Polyethlene Glycol Dimethacrylate Hydrogel Storage Modulus on Osteoarthitic Primary Human Chondrocyte Extracellular Matrix Production Laura Smith, Scott Weiner, Matthew Becker Poster No. 0679 Can a Fibrin Clot Enhance Healing in Double Bundle ACL Reconstruction in a Caprine Model? Daniel Hensler, Kenneth Illingworth, Zachary M Working, Volker Musahl, Tetsuo Kobayashi, Johnny Huard, Freddie H Fu Poster No. 0669 Tissue engineering under inflammatory conditions: the effect of scaffold material on cartilage stability Li Zeng, Heenam Kwon, David Kaplan, Dana Cairns, Li Sun PS1 Cartilage/Meniscus/ Synovium - Genetics/Genomics Poster No. 0670 Engineered Cartilage Retains a Much Greater Fraction of Synthesized GAG and Collagen than COMP Robert Nims, Alexander D Cigan, Michael Albro, Katherine C Wood, Clark T Hung, Gerard A Ateshian Poster No. 0671 Decellularized Stem Cell Matrix Rejuvenates Synovium-Derived Stem Cells for Cartilage Regeneration and Repair of Partial-Thickness Cartilage Defects Ming Pei, Fan He, Jingting Li Poster No. 0672 Co-culture of Chondrocytes and Adipose-Derived Stem Cells in Three-dimensional Biomimetic Hydrogels Promotes Stem Cell Chondrogenesis and Maintains Chondrocyte Phenotype Janice Lai, Glen Kajiyama, Fan Yang Poster No. 0673 Multi-Scale Analysis of Heterogeneity in Mesenchymal Stem Cell Chondrogenesis Megan J Farrell, Brian D Cosgrove, Stefan de Vries, Arjun Raj, Robert L Mauck Poster No. 0674 Biological Response of Cartilage Articulating Against Pyrolytic Carbon in Comparison to Cobalt-Chromium Alloy Carol Pacione, Susanna Chubinskaya, Markus A Wimmer Poster No. 0675 Development of injectable hyaluronan modified thermo-responsive hydrogel for adipose-derived stem cell based articular cartilage tissue engineering Chau-Zen Wang, Tzu Hsiang Lin, Rajalashmanan Eswaramoorthy, ShunCheng Wu, Je-Ken Chang, Gwo-Jaw Wang, Mei Ling Ho Poster No. 0676 Comparison of Efficacy of IGF-I Transfection in Adult and Juvenile Chondrocytes Izath N Aguilar, Stephen Trippel, Lawrence Bonassar Poster No. 0677 Synthesis and Incorporation of Latent TGF-β into the Extracellular Matrix of Engineered Cartilage Constructs Michael Albro, Alex Cigan, Robert Nims, Brenda Chen, Clark T Hung, Gerard A Ateshian Posters Poster No. 0667 Effect of Polyethlene Glycol Dimethacrylate Hydrogel Storage Modulus on Osteoarthitic Primary Human Chondrocyte Cytoskeletal Structure and Proliferation Laura Smith, Scott Weiner, Matthew Becker Poster No. 0680 The Varus Knee Reveals Differential Expression Patterns of miRNAs in Spared vs. Non-spared Compartments Paul J Fanning, Brian C Ayers, Marie E Walcott, Gary S Stein, David C Ayers, Jane B Lian Poster No. 0681 Human articular cartilage zone specific gene expression profiling Chantal Pauli, Shawn P Grogan, Stuart Duffy, Darryl D D’Lima, Martin K Lotz Poster No. 0682 A Proteomic Approach for Identification and Localization of the Pericellular Components of Chondrocytes in Osteoarthritic Cartilage Zijun Zhang, Wu Jin, Jeffrey Buckett, Thomas Otto, Berton Moed Poster No. 0683 Overexpression of PTHrP-related miRNA Enhances Chondrogenesis and Inhibits Hypertrophy in Human Bone Marrow Derived Stem Cells Jong Min Lee, Kyung-Il Kim, Jung Min Ahn, Gun-Il Im Poster No. 0684 GWAS of Osteoarthritis Biomarkers Serum Hyaluronic Acid and Cartilage Oligomeric Matrix Protein Implicates FOXN4, ETV6, KIAA1217, ZNF521, and CSGALNACT1 Heather B Coan, Ahsan Choudary, Dan P Nicolella, Tom D Dyer, Joanne E Curran, Melanie C Carless, Satish Kumar, Jack W Kent Jr, Laura A Almasy, Harald H Goring, John Blangero, Michael C Mahaney, Lorena M Havill Poster No. 0685 Increased Methylation Status of SOX-9 promoter in Human Osteoarthritic Cartilage Chang-Nim Im, Gun-il Im, HyunJi Oh, Go-Woon Kim Poster No. 0686 Genetic contributions to murine models of articular cartilage regeneration and ear-wound healing Muhammad Farooq Rai, Shingo Hashimoto, Eric E Johnson, Jamie Fitzgerald, Ellen Heber-Katz, James M Cheverud, Linda J Sandell Poster No. 0687 Effects of Joint Contracture on the Contralateral Unoperated Limb in a Rabbit Knee Contracture Model: A Biomechanical and Genetic Study Matthew P Abdel, Mark E Morrey, Diane Grill, Christopher Kolbert, Scott P Steinmann, Kai-Nan An, Joaquin Sanchez-Sotelo, Bernard Morrey 89 Posters Poster No. 0688 Analysis of functions of miR-199a-3p and miR-320c in chondrocytes Taku Ukai, Masato Sato, Hidenori Akutsu, Akihiro Umezawa, Toshihiro Nagai, Mami Kokubo, Joji Mochida Poster No. 0689 Identification of miRNA which regulates chondrogenic differentiation of MSC through direct targeting of Lymphoid Enhancer binding Factor 1 (LEF-1) Suel Ki Lee, Seungil Paik, Sung Hwan Kim, Woo Jin Choi, Jin Woo Lee Poster No. 0690 HDAC inhibitors decrease gene expression in chondrocytes cultured under high tensile strain Veronica Ulici, Juan Taboas, Peter Alexander, Rocky Tuan PS1 Cartilage/Meniscus/Synovium Cartilage & Matrix Proteins Poster No. 0691 Potential Role of 3-Hydroxyproline in Type X Collagen Network Assembly Jiann-Jiu Wu, MaryAnn Weis, Lammy Kim, David R Eyre Poster No. 0692 Molecular Adhesion between Cartilage Extracellular Matrix Constituents Fredrick P Rojas, C. Alexander Lindburg, Delphine Dean, Alan J Grodzinsky, Christine Ortiz, Lin Han Poster No. 0693 Determining the Mechanical Function of Type VI Collagen and Decorin in hMSCs undergoing Chondrogenesis Julianne D Twomey, Pratiksha I Thakore, Emmarie G Myers, Adam H Hsieh Poster No. 0694 A Recombinant Protein Expression System for the Study of Collagen VI Assembly: Does the New Chain α6(VI) Assemble into a Heterotrimer with α1(VI) and α2(VI)? What is its Function? Paul Holden, Cathleen Moscibrocki, Jamie Fitzgerald Poster No. 0695 Estrogen receptor does not regulate type X collagen gene expression on early differentiation of ATDC5 chondrogenic progenitor cells Yosuke Hattori, Toshihisa Kojima, Daizo Kato, Hiroyuki Matsubara, Naoki Ishiguro Poster No. 0696 Effect of Arendronate on Proteoglycan Production and Cell Metabolism in Bovine Articular Chondrocytes in Alginate Culture Shigeru Kobayashi, Tsuyoshi Miyazaki, Adam Meir, Hisatoshi Baba Poster No. 0697 Effect of collagen hydrolysates on human osteoarthritic cartilage explants Juergen Steinmeyer, Saskia Schadow, Jens Kordelle, Guenter Lochnit Poster No. 0698 Fibronectin Splice Variation in Human Knee Cartilage, Meniscus and Synovial Membrane: Association with Cartilage Degeneration Carla R Scanzello, Dessislava Z Markova, Sherrill L Adams, David G Anderson, Howard An, Yejia Zhang 90 PS1 Cartilage/Meniscus/Synovium Cartilage Matrix Degradation Poster No. 0699 Effects of the Number, Not the Length, of Chondroitin Sulfate Chains on Aggrecan Metabolism and Endochondral Ossification Hiroyasu Ogawa, Takashi Sato, Sonoko Hatano, Hisashi Narimatsu, Koji Kimata, Katsuji Shimizu, Hideto Watanabe Poster No. 0700 Knee Loading Reduces mRNA Expression of MMP-1 and MMP-13 in the Articular Cartilage and Synovium Liming Zhao, Andrew Rophie, Amin M Hagyousif, Stanley Chien, Hui B Sun, Hiroki Yokota Poster No. 0701 Accumulation of Advanced Glycation Endproducts Induces Cartilage Degradation via Activation of Syndecan-4-ADAMTS-5 Pathway Takuya Ruike, Daniel Leong, Fabrizio Grosjean, Vittoria Esposito, Robert J Majeska, James Iatridis, Helen Vlassara, Gary E Striker, Herb B Sun Poster No. 0702 Versican Proteolysis by ADAMTS Proteases Modulates Chondrogenesis In Vitro Jason C Ho, Suneel S Apte Poster No. 0703 CCAAT enhancer binding protein beta(C/EBPβ) regulates expression of matrix metalloproteinase-3(MMP-3) and aggrecanase-2 (ADAMTS-5) in arthritis Hidetoshi Tsushima, Ken Okazaki, Mitsumasa Hayashida, Takahiro Ushijima, Yukihide Iwamoto Poster No. 0704 Hyaluronan Oligosaccarides Induce Matrix Metalloproteinase-1 and 3 via Transcriptional Activation of NF-κB and p38 MAP kinase in rheumatoid synovial fibroblasts Masahiro Hanabayashi, Toshihisa Kojima, Nobunori Takahashi, Shinya Hirabara, Naoki Ishiguro Poster No. 0705 Local Anesthetics Activate Fibroblast-like Synoviocytes and Induce Matrix Metalloproteinase Production Hillary J Braun, Benjamin T Busfield, Hyeon Joo Kim, Gaetano Scuderi, Jason Dragoo Poster No. 0706 Severe articular cartilage aggrecan depletion by inducible ADAMTS5 does not lead to OA in young mice under laboratory conditions P. van der Kraan, F. Kolb, E. Vitters, S. Barbieri, U. Bodendorf, N. Gerwin, W. van den Berg Poster No. 0707 Sources of Nutrition and Articular Cartilage Degeneration: An Experimental Study Lei Wei, Yuze Wang, Yuzhi Wei, Xiaochun Wei Poster No. 0708 Exosome derived from osteoarthritis cartilage induces catabolic factor gene expressions in synovium Tomoyuki Nakasa, Shigeru Miyaki, Tomohiro Kato, Tsuyoshi Takada, Yoshihiro Nakamura, Mitsuo Ochi Poster No. 0710 An In Vitro Model of the Pathological Degradation in Osteoarthritis Stephanie Grenier, Peter A Torzilli, Madhu M Bhargava PS1 Cartilage/Meniscus/Synovium Cytokines Poster No. 0711 Inhibition of Interleukin-1 Prevents Post-Traumatic Arthritis Following Articular Fracture in the Mouse Knee Daniel S Mangiapani, Evan Zeitler, Bridgette D Furman, Janet L Huebner, Virginia B Kraus, Farshid Guilak, Steven A Olson Poster No. 0712 IL-1 alpha is a More Potent Inducer of Cartilage and Meniscus Degradation than IL-1 beta at Physiologic Levels Amy L McNulty, Holly Leddy, Farshid Guilak Poster No. 0713 Preexposure of Engineered Cartilage to Interleukin-1α Affords Protection against Subsequent Cytokine Exposure Andrea R Tan, Curtis D VandenBerg, Gerard A Ateshian, Clark T Hung Poster No. 0714 Inhibition of PARP-1 Mediated Cell Death Induced by Oxidative Damage in Bovine Chondrocytes Borami Shin, Conrad Alano, Haufei Lu, Alfred Kuo, Hubert Kim Poster No. 0715 24R,25dihydroxyvitmin D3 Prevents Articular Cartilage Degradation Induced by IL-1b Qingfen Pan, Rene Olivares-Navarrete, Sharon L Hyzy, Zvi Schwartz, Barbara D Boyan Poster No. 0716 Role of NF-κB and MAPK in IL-1β induced Proteoglycan Degradation in Articular Cartilage Jeomi Maduka, Joseph Kilianski, Vino Urity, Christopher T Chen Poster No. 0717 Integrin α1β1 is Necessary for Chondrocyte Response to Interleukin-1α Melissa K Lorenzo, Ambra Pozzi, Andrea Clark Poster No. 0718 ERCC1 Regulation of Human Chondrocytes Senescence Koji Takayama, Satoshi Terada, Sahnghoon Lee, Xiaodong Mu, Arvydas Usas, Burhan Gharaibeh, Freddie H Fu, Johnny Huard Poster No. 0719 Expression of angiotensin II receptor-1 (AT1R) in human articular chondrocytes Kosuke Matsuo, Yuki Kawakami, Yutaka Inaba, Minako Murata, Kazuo Yudoh, Hiroshi Nakamura, Tomohiro Kato, Kayo Masuko, Tomoyuki Saito PS1 Cartilage/Meniscus/Synovium - Growth Factors & Aging Posters Poster No. 0709 An Autologous Anti-Inflammatory Solution Inhibits IL-1α-induced GAG Release from Bovine Cartilage Explants Jennifer Woodell-May, Andrea Matuska, Krista O’Shaughnessey Poster No. 0720 Chondrocyte-intrinsic Smad3 is Required for Normal Articular Cartilage Maintenance Carol Chen, Daniel Thuillier, Tamara Alliston Poster No. 0721 Enhanced Binding of COMP to TGF-beta1: Effect of Deletions in the TSP-type 3 domain Chitrangada Acharya, Jasper Yik, Paul E Di Cesare, Dominik R Haudenschild Poster No. 0722 Increased Subchondral Bone Mass with No Histological Changes in Articular Cartilage in Sclerostin Knockout Mice and Rats Treated with Sclerostin Monoclonal Antibody Hua Z Ke, Qing-Tian Niu, Xiaodong Li Poster No. 0723 FGF2 and TGFβ1 induce precocious maturation of articular cartilage Ilyas M Khan, Lewis Francis, Peter Theobald, Steve Conlan, Charles W Archer Poster No. 0724 C/EBPβ regulates GADD45β gene expression in osteoarthritic chondrocytes Hirofumi Shimada, Kaneyuki Tsuchimochi, Harutoshi Sakakima, Fumiyo Matsuda, Megumi Sakasegawa, Yefu Li, Setsuro Komiya, Mary B Goldring, Kosei Ijiri Poster No. 0725 PTHrP modulates thyroid hormone signaling through PP2A/HDAC4 pathway in growth plate chondrocytes Lai Wang, Yvonne Shao, R. Tracy Ballock Poster No. 0726 Calcium Calmodulin Protein Kinase II Regulates 1α,25(OH)2D3 Membrane-Mediated Rapid Signaling in Chondrocytes and Osteoblasts Maryam Doroudi, Zvi Schwartz, Barbara D Boyan Poster No. 0727 WISP-1 induces VCAM-1 expression in human synovial fibroblasts through Syk, PKC delta, JNK and AP-1 pathway Ju-Fang Liu, Chih-Shin Tang, Sheng-Mou Hou, Chun-Han Hou Poster No. 0728 Human chitinase 3-like protein 2 (YKL39) is a novel secreted protein which supports cell proliferation and chondrocytic differentiation of ATDC5 Kazumasa Miyatake, Mika Yamaga, Ichiro Sekiya, Takeshi Muneta, Kunikazu Tsuji 91 Posters Poster No. 0729 Synovial-derived mesenchymal stromal cells transduced to secrete BMP2, BMP14, or FGF18 promote chondrogenesis in an autogeneic co-culture model Seth Jump, Vincent Y Ng, Eric Skinner, David Flanigan, Alicia Bertone Poster No. 0739 The Effect of Osteochondral Autograft on Articular Cartilage Structure at 6 and 12 Months in the Goat Christopher B Raub, Ssu-Chieh Hsu, Elaine F Chan, Albert Chen, Evangelia Chnari, Eric J Semler, Robert L Sah PS1 Cartilage/Meniscus/ Synovium - Cartilage Repair Poster No. 0740 Cell cycle exit marks the initiation of cartilage formation in biomaterial scaffolds Elina Järvinen, Virpi Muhonen, Ville Ellä, Anne-Marie Haaparanta, AnnaMarja Säämänen, Ilkka Kiviranta Poster No. 0730 Aggrecan mimic enhances mechanical properties of aligned collagen gels Shaili Sharma, Jonathan Bernhard, Alyssa Panitch Poster No. 0731 Effects of Hydroxyapatite and T3-Stimulation on Deep Zone Chondrocyte Growth and Biosynthesis on a Nanofiber Scaffold Philip J Chuang, Nora T Khanarian, Kristen L Moffat, Neha Paralkar, Helen Lu Poster No. 0741 Double-network Hydrogel Implantation Induces Spontaneous Hyaline Cartilage Regeneration In Vivo in a Large Osteochondral Defect Created at the Patellofemoral and Tibiofemoral Joints in a Sheep Model Masashi Yokota, Nobuto Kitamura, Eiji Kondo, Takayuki Kurokawa, Takaaki Fukui, Katsuhisa Yoshikawa, Jian Ping Gong, Kazunori Yasuda Poster No. 0732 Early and Sustained Response of chondrocytes to Biomaterials; a Comparative Study of Four Different Biomaterials Anika Tsuchida, Joris Bekkers, Lucienne Vonk, Daniel Saris, Wouter Dhert, Laura Creemers Poster No. 0742 The In Vivo Performance of Osteochondral Allografts in the Goat is Diminished with Extended Storage and Decreased Cartilage Cellularity Andrea L Pallante, Simon Gortz, Albert C Chen, David Amiel, Koichi Masuda, Robert L Sah, William D Bugbee Poster No. 0733 Improved Function of Scaffold-Free Engineered Cartilage Under Combined Compressive and Shear Loads G Adam Whitney, Joseph M Mansour, James E Dennis Poster No. 0743 The Positive Effects of Osteochondral Repair Using Continuous Passive Motion and Cell-free Scaffold Nai-Jen Chang, Nontapot Issariyaku, Chih-Chan Lin, Chien-Feng Lin, Ming-Long Yeh Poster No. 0734 A Surface Replacement Scaffold Can Regenerate Cartilage and Measure In Vivo Shear Loads John A Szivek, Gregory J Heden, Nick H Diggins, John T Ruth Poster No. 0744 PGE2 signal through EP2 agonist promotes regeneration of injured articular cartilage Seiji Otsuka, Tomoki Aoyama, Mritoshi Furu, KInya Ito, Takayuki Maruyama, Toshiya Kanaji, Akio Nishiura, Hikaru Sugihara, Shinsei Fujimura, Takanobu Otsuka, Junya Toguchida Poster No. 0735 Porous Cartilage-Derived Matrix Scaffolds for Repair of Articular Cartilage Defects Nipun Chadha, Alexis Dang, Erik Sampson, Subhash Juneja, Tony Chen, Bradley Estes, Farshid Guilak, Michael Zuscik, Randy Rosier, Edward M Schwarz, Michael Maloney, Hani A Awad Poster No. 0736 Micellar and Liposomal Pharmaceutical Nanocarrier Association with Articular Cartilage Using an In-Vitro Model Khaled A Elsaid, Lisa Ferreira, Anna Liang, Gerard D’Souza Poster No. 0737 Repair of Rabbit Osteochondral Defects by an Acellular Technique with an Ultrapurified Alginate Gel Containing Stromal Cell-Derived Factor-1 Atsushi Sukegawa, Norimasa Iwasaki, Yasuhiko Kasahara, Tomohiro Onodera, Tatsuya Igarashi, Akio Minami Poster No. 0738 Implantation of a Crosslinked Salmon Collagen Sponge Disc with Osteogenic Protein-1 (BMP-7) Induces Spontaneous Hyaline Cartilage Regeneration in a Large Osteochondral Defect Hiroyuki Mori, Eiji Kondo, Yasuyuki Kawaguchi, Nobuto Kitamura, Nobuhiro Nagai, Masanobu Munekata, Hirokazu Iida, Kazunori Yasuda 92 Poster No. 0745 Effect of Tenascin-C on the repair of full-thickness osteochondral defects of articular cartilage in rabbits Shigeto Ikemura, Masahiro Hasegawa, Takahiro Iino, Koji Akeda, Keiichi Miyamoto, Kyoko Imanaka-Yoshida, Toshimichi Yoshida, Akihiro Sudo Poster No. 0746 Regeneration of Bone and Cartilage Tissue in an Osteochondral Defect following treatment with a Novel Multi-Layered CollagenBased Scaffold Tanya J Levingstone, Alexander Schepens, Emmet Thompson, Fergal J O’Brien, John P Gleeson Poster No. 0747 Comparison of Histological Grading to Fourier Transform Infrared Imaging Analysis of Cartilage Repair Tissue Megan P O’Brien, Nancy Pleshko Poster No. 0758 Culture of Primary Bovine Chondrocytes on a Continuously Expanding Surface Inhibits Dedifferentiation Derek H Rosenzweig, Mourad Matmati, Ghazaleh Khayat, Sidharth Chaudhry, Boris Hinz, Thomas M Quinn Poster No. 0749 Comparison of Fresh and Decellularized Osteochondral Graft in a Rabbit Trochlear Groove Model Eran Rosines, Qian K Kang, Yuehuei H An, Ashley M Bowman, Jingsong Chen, Silvia Chen Poster No. 0759 Cocultures of human infrapatellar fat pad derived MSCs and articular chondrocytes from OA patients: an alternative to BMSCs for cartilage tissue engineering applications Silvia Lopa, Alessandra Colombini, Laura de Girolamo, Valerio Sansone, Luigi Zagra, Matteo Moretti Poster No. 0750 The effect of atelocollagen membrane coverage combined with subchondral drilling on cartilage regeneration Michio Hamanishi, Tomoyuki Nakasa, Naosuke Kamei, Goki Kamei, Hiromi Kazusa, Mitsuo Ochi PS1 Cartilage/Meniscus/Synovium Cartilage Repair - Cell Based Approaches Poster No. 0751 Removal from Defined Media Reduces Properties of MSC-Laden HA Hydrogels after Transient TGF-beta3 Exposure Minwook Kim, Sean Garrity, Marwa Choudhury, Isaac Erickson, Robert L Mauck Poster No. 0752 P15 Peptide Enhances Chondrogenesis and Endochondral Ossification Gursukhman Deep S Sidhu, Jun Zhang, Christine Macolino, Alexander R Vaccaro, Theresa A Freeman Poster No. 0753 Properties and effectiveness of aggregated synovial mesenchymal stem cells for cartilage regeneration Shiro Suzuki, Ichiro Sekiya, Kunikazu Tsuji, Takeshi Muneta Poster No. 0754 IL-6 signaling enhances the BMP-responsiveness of human MPCs in chondrogenic culture Ryan M Porter, Elizabete Ferreira, Lennart Brown, Christopher Evans Poster No. 0755 Chondrogenic potential of dedifferentiated human osteoarthritic chondrocytes and their phenotypic alterations during de- and re-differentiation process in vitro Yohei Ohno, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Motoshige Nakashima, Shinya Ishizuka, Tetsuya Matsukawa, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita, Naoki Ishiguro Poster No. 0756 Low Glucose Conditions Enhance Phenotypic Stability During Chondrocyte Expansion in Monolayer Hannah K Heywood, David A Lee, Francesco Dell’Accio Posters Poster No. 0748 Implantation of a 1-mm Thick Double-network Gel Sheet Can Induce Spontaneous Articular Cartilage Regeneration In Vivo in a Large Osteochondral Defect Hidetoshi Matsuda, Nobuto Kitamura, Eiji Kondo, Takayuki Kurokawa, Kazunobu Arakaki, Jian P Gong, Fuminori Kanaya, Kazunori Yasuda Poster No. 0760 Repair Effects of an Injectable Platelet-Rich Plasma Gel Encapsulated with Synovium-Derived Mesenchymal Stem Cells on Articular Cartilage Defects in a Rabbit Model Jae-Chul Lee, Hyun Jin Min, Jak Jang, Sahnghoon Lee, Sang Cheol Seong, Myung chul Lee Poster No. 0761 Adhesive Effects of Recombinant Transglutaminase 4 on Human Synovium-Derived Mesenchymal Stem Cells to Fibronectin Hyun Jin Min, Jae-Chul Lee, Jak Jang, Shanghoon Lee, Sang Cheol Seong, Myung chul Lee Poster No. 0762 The Role of TGF-beta/BMP Signaling in Terminal Differentiation in in vitro Chondrogenesis of Mesenchymal Stem Cells Alexandra Karl, Richard Kujat, Johannes Zellner, Michael Nerlich, Peter Angele, Michael B Mueller PS1 Cartilage/Meniscus/ Synovium - Meniscus Poster No. 0763 The Effect of Arthroscopic Partial Meniscectomy on Tibiofemoral Stability Sally Arno, Scott Hadley, Kirk A Campbell, Christopher P Bell, Michael Hall, Luis S Beltran, Michael P Recht, Orrin H Sherman, Peter S Walker Poster No. 0764 Comparison of All-Inside Meniscal Repair Devices with Matched Inside-Out Suture Repair Brett McKenzie, Claudio Rosso, Konstantin Kovtun, William Dow, Marc A Mueller, Ara Nazarian, Joseph P DeAngelis, Arun J Ramappa Poster No. 0765 Variance in gene expression of human meniscal tears by patient age, sex and ACL status Robert H Brophy, Mohammed F Rai, Zhiqi Zhang, Adelina Torgomyan, Linda J Sandell Poster No. 0766 Effects of 17beta-estradiol on IL-1 alpha-mediated matrix degradation in the meniscus Bodo Kurz, Kristian Ewald, Hendrik Naujokat, Michael Schuenke Poster No. 0757 Clusterin in Biopsies of Repair Tissue following Autologous Chondrocyte Implantation Helen S McCarthy, Jos Malda, Sally Roberts 93 Posters Poster No. 0767 Measurement of Meniscal Surface Layer Thickness Using Optical Coherence Tomography Carrie Hang-yin Ling, Marc E Levenston Poster No. 0768 Cationic Contrast Enhanced CT Imaging Can Predict the GAG Distribution of Bovine Meniscus Ben Lakin, Dan Grasso, Rachel C Stewart, Brian D Snyder, Mark W Grinstaff Poster No. 0769 The Influence of Interleukin-1 and Transforming Growth Factor-β1 on Cell Proliferation and Repair in the Meniscus Amy L McNulty, Katherine Riera, Nicole Rothfusz, Rebecca E Wilusz, Joe B Weinberg, Farshid Guilak Poster No. 0770 Biomechanical Properties of Murine Meniscus via Nanoindentation Lin Han, Dorothy E Pazin, Vicki Rosen, Michael Batista, Christine Ortiz, Alan J Grodzinsky Poster No. 0771 Relationship between cartilage wear and meniscal contact in medial osteoarthritis of the knee Sally Arno, Peter S Walker, Christopher Bell, Svetlana Krasnokutsky, Jonathan Samuels, Stephen Abramson, Ravinder Regatte, Michael Recht, Sherry Liang, Gokce Yildirim Poster No. 0772 Increased expression of Hypoxia-inducible factor-2α in osteoarthritic meniscus cells Shinya Ishizuka, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Motoshige Nakashima, Youhei Ohno, Tetsuya Matsukawa, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita, Naoki Ishiguro Poster No. 0773 Non-invasive Assessment of Meniscus Subsurface Integrity with Ultrashort TE-Enhanced T2* Mapping Ashley Williams, Yongxian Qian, Constance R Chu Poster No. 0774 Effect of Partial Meniscectomy at The Medial Posterior Horn After A Radial Tear on Tibiofemoral Contact Mechanics and Meniscal Hoop Strains in Human Knees Andreas M Seitz, Anja Lubomierski, Bendikt Friemert, Anita Ignatius, Lutz Dürselen Poster No. 0775 Regional Comparisons of Nano-mechanical Properties on Human Meniscal Surfaces John T Moyer, Adam C Abraham, Tammy Haut Donahue Poster No. 0776 Modulation of the Meniscus Repair Interface via Collagenase Delivery from Nanofibrous Composites Feini Qu, John L Esterhai, Robert L Mauck 94 PS1 Cell & Molecular Imaging of Cartilage Poster No. 0777 Ultra-high Resolution μ-Arthrography Approach to Accessing Cartilage Thickness in a Murine Model Xiang I Gu, Paolo Palacio, Daniel J Leong, Damien Laudier, Robert J Majeska, Mitchell B Schaffler, Herb B Sun, Luis Cardoso Poster No. 0778 Localization of Articular Cartilage Damage in the Rat Medial Meniscus Tear Model for Osteoarthritis Using Contrast Based MicroCT Imaging Tanushree Thote, Nick Willett, Angela Lin, Shamus Moran, Robert Guldberg Poster No. 0779 In Vivo Imaging of Inflammation, Bone Formation, and Bone Resorption In A Mouse Model of Post-Traumatic Osteoarthritis Nicole De Jesus, Matthew J Anderson, Dominik R Haudenschild, Crystal M Ripplinger, Blaine A Christiansen Poster No. 0780 Contrast-Based Micro-CT Imaging of Murine Articular Cartilage Morphology and Damage Angela Lin, Tanushree Thote, Nick J Willett, Robert E Guldberg Poster No. 0781 In Situ Intracellular Calcium Imaging of Chondrocytes in Intact Cartilage Wen Li, Xin Lu, Liyun Wang Poster No. 0782 Contrast Enhanced CT Imaging Can Detect Wear of Bovine Articular Cartilage Using a Cationic Contrast Agent Ben Lakin, Dan Grasso, Mark W Grinstaff, Brian D Snyder Poster No. 0783 Cluster analysis of infrared spectra of repaired articular cartilage Yevgeniya Kobrina, Lassi Rieppo, Simo Saarakkala, Ilka Kiviranta, Jukka S Jurvelin, Hanna Isaksson Poster No. 0784 Macromolecular Concentrations in Articular Cartilage by Fourier Transform Infrared Imaging Yang Xia, Jianhua Yin Poster No. 0785 A Cationic Computed Tomography Contrast Agent Partitions in Articular Cartilage According to Donnan Equilibrium Rachel C Stewart, Jonathan Freedman, Hrvoje Lusic, Brian D Snyder, Mark W Grinstaff Poster No. 0786 Early Cartilage Degenerative Change in Patients with ACL Rupture - 3D reconstructed T2 mapping study Satoru Tamura, Takashi Nishii, Ken Nakata, Toshiyuki Shiomi, Youichi Yamazaki, Kenya Murase, Hisashi Tanaka, Keisuke Kita, Tatsuo Mae, Hideki Yoshikawa, Nobuhiko Sugano Poster No. 0787 Effect of Neurotropin® on Dorsal Root Ganglion Cytokine and Pain Marker Expression in the Thrombin-induced Facet Joint Arthritis Model Rajeswari Pichika, Tomonori Yamaguchi, Mary E Lenz, M. Naiki, Koichi Masuda Poster No. 0788 Spontaneous Osteoarthritis Develops Earlier and Begins in the Subchondral Bone of the Integrin α1-null Mouse Knee Sung Yong Shin, Andrea Clark, Ambra Pozzi Poster No. 0789 T-2 toxin and low selenium alters the expression of chondroitin sulphate sulphation motifs in articular cartilage in an animal model of Kashin-Beck disease Bruce Caterson, Siyuan Li, Jinghong Chen, Clare E Hughes Poster No. 0790 Transcription Factor Nfat1 Deficiency: A Risk Factor for Progression of Posttraumatic Osteoarthritis in Mice William C Kramer, Qinghua Lu, Jinxi Wang Poster No. 0791 ACL transection decreases the residence time of high-molecular weight hyaluronan in synovial fluid William J McCarty, Justin C Cheng, Bradley C Hansen, Tomonori Yamaguchi, Koichi Masuda, Robert L Sah Poster No. 0792 Joint Distraction in Treatment of Canine Experimentally Induced Osteoarthritis leads to Cartilage Repair accompanied by Sustained Relieve of Pain Karen Wiegant, Simon C Mastbergen, Femke Intema, Peter M van Roermund, Herman A Hazewinkel, Floris P Lafeber Poster No. 0793 Prevention of osteoarthritis by administration of anti-VEGF antibody Bevacizumab Toshihiro Nagai, Masato Sato, Taku Ukai, Miyuki Kobayashi, Joji Mochida Poster No. 0794 Characterization of Cartilage Boundary Lubricant Composition and Function of Ovine Synovial Fluid Following Knee Surgery Kristen I Barton, Taryn Ludwig, Yamini Archari, Nigel Shrive, Cyril Frank, Tannin Schmidt Poster No. 0795 Interruption of Glycosphingolipid Synthesis Enhances Osteoarthritis Development in Mice Naoki Seito, Norimasa Iwasaki, Tadashi Yamashita, Yukinori Tsukuda, Yuichiro Matsui, Atsushi Urita, Tomohiro Onodera, Naoki Fujitani, Yasuro Shinohara, Akio Minami Poster No. 0796 A single injection of adipose-derived stem cells (ASCs) protects against cartilage damage and lowers synovial activation in experimental osteoarthritis Menno ter Huurne, Peter L van Lent, Arjen B Blom, Roxane Blattes, Yannick Jeanson, Christian Jorgensen, Louis Casteilla, Wim B van den Berg Poster No. 0797 Perlecan HS Ablation Reduces Cartilage Degradation and Osteophytosis in Post-Traumatic Osteoarthritis Cindy C Shu, Christopher B Little, James Melrose Poster No. 0798 In vivo reduction or blockade of interleukin-1β in primary osteoarthritis influences expression of mediators implicated in pathogenesis Kelly S Santangelo, Gerard Nuovo, Alicia Bertone Posters PS1 Cartilage/Meniscus/ Synovium - Osteoarthritis Poster No. 0799 Prophylactic injection of hyaluronan activates chondrogenic genes and induces periarticular cartilage deposition in murine knee osteoarthritis Jun Li, Jennifer Velasco, Daniel Gorski, Jun Takeuchi, John Sandy, Anna Plaas Poster No. 0800 The role of activated macrophages in the progression of osteoarthritis Michiel Siebelt, Harald Groen, Marjan Sandker, Erwin Waarsing, Marion de Jong, Jan Verhaar, Holger Jahr, Harrie Weinans Poster No. 0801 The Effect of Mutations in Low-Density Lipoprotein Receptor Related Protein 6 (LRP6) on Osteoarthritis Progression in a Murine Injury Model Danese M Joiner, Donald J Scholten, Kennen D Less, Michael Morris, Jim Mason Poster No. 0802 Loading Rate-Dependent Subchondral Bone Changes in a Mouse Model of Post-Traumatic Osteoarthritis Matthew J Anderson, Dominik R Haudenschild, Blaine A Christiansen Poster No. 0803 Alterations to the Subchondral Bone Structure during Osteoarthritis: Bone Adaptation versus Endochondral Bone Formation Lieke G Cox, Corrinus C van Donkelaar, Bert van Rietbergen, Pieter J Emans, Keita Ito Poster No. 0804 The Role of the Progressive Ankylosis Protein (ANK) in Osteoarthritis Takeshi Minashima, Kirk Campbell, Ying Zhang, Martin Quirno, Thorsten Kirsch Poster No. 0805 Osteoarthritis Severity is Reduced in MIF Knockout Mice Laura Pritzker, Margaret A McNulty, Richard F Loeser, Richard Miller, Cathy S Carlson Poster No. 0806 Gait Analysis of Model Mouse of Knee Osteoarthritis Induced by Surgical Destabilization of Medial Meniscus using Catwalk System Masahiko Saito, Takahisa Sasho, Satoshi Yamaguchi, Naoshi Ikegawa, Ryuichiro Akagi, Yuuta Muramatsu, Shunsuke Mukouyama, Kazuhisa Takahashi 95 Posters Poster No. 0807 Analgesic effect of intra-articular ASIC3 blocker injection in a rat model of osteoarthritis Masashi Izumi, Masahiko Ikeuchi, Ji Qinghui, Natsuki Sugimura, Toshikazu Tani Poster No. 0808 A Canine Model of Medial Compartment Gonarthrosis James L Cook, Keiichi Kuroki, Aaron M Stoker, Cristi Cook PS1 Cartilage/Meniscus/ Synovium - Cartilage Mechanics Poster No. 0809 Ionic environment affects the aggregation and lubrication behavior of recombinant human lubricin Natalie Galley, Jenny Lin, Carl Flannery, Lawrence Bonassar Poster No. 0810 The Effects of Enzymatic Treatments on the Viscoelastic Shear Properties of Articular Cartilage Darvin Griffin, Jesse Silverburg, Itai Cohen, Lawrence Bonassar Poster No. 0811 Internal and Regional Strains in Human OA Articular Cartilage as Measured by Displacement-Encoded MRI Adam J Griebel, Steve B Trippel, Corey P Neu Poster No. 0812 Multiscale assessment of the osteochondral interface width in the femoral head Sara E Campbell, Donna C Hurley, Virginia Ferguson Poster No. 0813 Cartilage-on-Cartilage Articulating System as a Wear Benchmark for Artificial Replacement Materials Jonathan Stoia, Carol Pacione, Susanna Chubinskaya, Markus A Wimmer Poster No. 0814 Non-invasive Investigation of Contact Mechanics of the Natural Hip Joint through Finite Element Modelling Sainath S Pawaskar, Zhongmin Jin, Eileen Ingham, John Fisher Poster No. 0815 Glenoid Cartilage Mechanical Properties Decrease after Rotator Cuff Tendon Tears in a Rat Model Katherine E Reuther, Joseph J Sarver, Chancellor F Gray, Chang S Lee, LeAnn Dourte, Susan M Schultz, Chandra M Sehgal, David L Glaser, Louis J Soslowsky Poster No. 0816 Finite Element Analysis Predicts Focal Defect Effects on Articular Cartilage Contact Mechanics Reza Shirazi, Robert L Sah, Stephen M Klisch Poster No. 0817 Model-based Analysis to Predict Biomechanics of Articular Cartilage Using Infrared Spectroscopy Lassi Rieppo, Simo Saarakkala, Jukka S Jurvelin, Jarno Rieppo 96 Poster No. 0818 In Vivo Stress Distribution Patterns at Osteochondral Donor Sites in the Patellofemoral Joint among Baseball Players Assessed by Computed Tomography Osteoabsorptiometry Kinya Nishida, Norimasa Iwasaki, Kazuhiro Fujisaki, Tadanao Funakoshi, Tamotsu Kamishima, Shigeru Tadano, Akio Minami Poster No. 0819 Depth-Dependent Anisotropy of the Micromechanical Properties of Porcine Articular Cartilage Measured via Atomic Force Microscopy Morgan A McLeod, Rebecca E Wilusz, Farshid Guilak Poster No. 0820 Role of Construct Size and Mechanical Properties on Failure of Adhesive Bond between Native and Tissue-Engineered Cartilage Ali Vahdati, Diane R Wagner Poster No. 0821 Investigation of Required Mechanical Properties of Adhesive Bond between Native and Tissue-Engineered Cartilage Ali Vahdati, Diane R Wagner Poster No. 0822 Damage Initiation and Progression in Articular Cartilage by Repeated Impact Loading Sayyed Mohsen Hosseini, Mariska B Veldink, Wouter Wilson, Keita Ito, Corrinus C van Donkelaar Poster No. 0823 Alterations in Fluid Pressurization in the Femoral Cartilage Following Partial Meniscectomy Mojtaba Kazemi Miraki, LePing Li Poster No. 0824 Biomechanical Consequences of Surgical Destabilization of the Medial Meniscus in the Rabbit Knee Marut Arunakul, Yuki Tochigi, Bryce Diestelmeier, Anneliese Heiner, Jessica E Goetz, Melvin J Rudert, Thomas Brown, Todd McKinley Poster No. 0825 A Novel Technique to Measure Rabbit Activity Using an Ambulatory Acceleration Monitor Bryce Diestelmeier, Yuki Tochigi PS1 Cartilage/Meniscus/Synovium Mechanobiology Poster No. 0826 Relating Stem Cell Shape Change to Fate Commitment by Mapping Cell Surface Strains In Situ Min Jae Song, Susann M Brady-Kalnay, David Dean, Melissa L Knothe Tate Poster No. 0827 Applied Dynamic Loading Following chABC Digestion Increases Collagen Production in Engineered Cartilage Grace D O’Connell, Michael A Carapezza, Isabella B Newman, Gerard A Ateshian, Clark T Hung Poster No. 0829 Biological Effects of Impact Maximum Compression on Osteochondral Explants Nicole Waters, Aaron M Stoker, William Carson, James L Cook Poster No. 0830 Spatial and Temporal Apoptotic Activity in Acutely Injured Cartilage Explants Derek H Rosenzweig, Hooi Chuan Chin, Thomas M Quinn Poster No. 0831 Expression of p53R2 in chondrocytes is regulated by mechanical stress Kohei Kawakita, Shinya Hayashi, Kenjiro Iwasa, Takayuki Nishiyama, Ken Takebe, Takaaki Fujishiro, Noriyuki Kanzaki, Masahiro Kurosaka Poster No. 0832 Shear is a requirement for mechanically induced chondrogenesis of human bone marrow derived stem cells Oliver Schätti, Sibylle Grad, Jürg Goldhahn, Mauro Alini, Martin J Stoddart Poster No. 0833 Osmolality Challenge Affects the Cell and Nuclear Deformation of Chondrocytes Seeded in Agarose and Subjected to Static Compression Loading Jerome Irianto, Martin M Knight, Rui P Martins, David A Lee PS1 Disease Process Knee - Joint Mechanics Poster No. 0834 Knee laxity after staircase exercise predicts radiographic disease progression in medial compartment knee osteoarthritis: an eightyear prospective observation Tsuyoshi Miyazaki, Kenzo Uchida, MItsuhiko Sato, Takafumi Yayama, Daisuke Sugita, Ai Yoshida, Hisatoshi Baba Poster No. 0838 Do Age and Sex-Related Variations in Material Properties Predict Prevalence of Knee Osteoarthritis? Andrea Morrell, Jason A Inzana, Paul D Funkenbusch, Amy L Lerner Poster No. 0839 Quantification of High-Flexion Stability in Natural Knees Amitkumar Mane, Iris Sauerberg, Eik Siggelkow, Marc BandiMuenchinger, Fred Wentorf Posters Poster No. 0828 Distortional Stress Inhibits Upregulation of ECMs and TGF-beta Genes by Hydrostatic Pressure in Human Articular Chondrocytes Shuichi Mizuno, Rei Ogawa, Tom Minas Poster No. 0840 A Comparison of In Vivo Knee Kinematics During Wide-Based Squatting Between ACL Deficient and Contralateral Intact Knees Takeshi Miyaji, Kazuyoshi Gamada, Kenichi Kidera, Akihiko Yonekura, Kei Yoneta, Futoshi Ikuta, Hiroyuki Shindo, Makoto Osaki Poster No. 0841 What is the Rate of Subsequent Surgery Following ACL Reconstruction? Short and Mid-term Follow-up from the MOON Cohort Carolyn M Hettrich, Warren R Dunn, Emily Reinke, Group Moon, Kurt P Spindler Poster No. 0842 The Relationship between Femoral Tunnels Created by Transtibial, Anteromedial Portal, and Outside-In Techniques and Anatomical Anterior Cruciate Ligament Footprint Hemanth R Gadikota, Jae-Ang Sim, Ali Hosseini, Thomas J Gill, Guoan Li Poster No. 0843 Grafts Fixation Angles for Anatomical Single Tunnel Double Bundle ACL Reconstruction Jae-Ang Sim, Hemanth R Gadikota, Thomas J Gill, Guoan Li Poster No. 0844 Single bundle ACL reconstruction in medial portal technique: Knee kinematics after femoral tunnel drilling with conventional over the top aimer in comparison to the new medial portal aimer, “MPA” Mirco Herbort, Christoph Domnick, Simon Lenschow, Wolf Petersen, Michael J Raschke, Thore Zantop Poster No. 0835 Factors Affecting the Change of Coronal Knee Alignment between Standing and Supine Position in Medial Advanced Osteoarthritis Masato Aratake, Yasushi Akamatsu, Naoto Mitsugi, Naoya Taki, Hirohiko Ota, Hideo Kobayashi, Taichi Ideno, Tomoyuki Saito Poster No. 0845 The effect of knee position in intraoperative lateral x-rays on the evaluation of intercondylar roof impingement Atsunori Murase, Masahiro Nozaki, Masaaki Kobayashi, Hideyuki Goto, Kaneaki Tawada, Yasuhiro Nishimori, Masato Yoshida, Yuko Nagaya, Hirotaka Iguchi, Noriyuki Watanabe, Takanobu Otuka Poster No. 0836 Femoral and Tibial Condyle Bone Mineral Density in Women with Symptomatic Knee Osteoarthritis Yasushi Akamatsu, Naoto Mitsugi, Masato Aratake, Hideo Kobayashi, Ken Kumagai, Yutaka Fujiwara, Yoshihiro Kusayama, Tomoyuki Saito Poster No. 0846 Evaluation of arthroscopic image distortion between different scopes and viewing portals Yuichi Hoshino, Daniel Hensler, Scott Tashman, Volker Musahl, Freddie H Fu Poster No. 0837 Investigation of Potential Causes of Knee Osteoarthritis using Functional Activity Tibiofemoral Loading Patterns Jennifer Boyd, Amy B Zavatsky, Harinderjit S Gill Poster No. 0847 Structural Properties of 5 Different Fixation Strategies in MPFL Reconstruction Simon Lenschow, Jens Gestring, Benedikt Schliemann, Mike Schroeglmann, Michael J Raschke, Thore Zantop 97 Posters Poster No. 0848 Anteriorization of the quadriceps tendon. A biomechanical study on a new technique for unloading the patellofemoral joint Jeremy Bruce, Michael Tew, Timothy B Ervin Poster No. 0849 Patellofemoral Pain: Classification by Physical Exam and WeightBearing MRI Kathleen Jacobs, Christie E Draper, Gary S Beaupre, Thor F Besier, Garry E Gold, Michael Fredericson Poster No. 0850 Validation of an MRI-based Method to Assess Patellofemoral Joint Contact Areas in Loaded Knee Flexion In Vivo Emily J McWalter, Colm M O’Kane, David R Wilson Poster No. 0851 Patellofemoral Contact Mechanics After Quadriceps Tendon Graft Harvest John R West, Geoffrey Bernas Poster No. 0852 What is the important factor related to the knee pain during the postoperative rehabilitation after the surgery for the fracture of the proximal femur? Kengo Harato, Toshiro Otani, Hiroki Yoshida Poster No. 0853 A Leg Press Exercise Restoring Screw-Home Movement Improves Short-Term Clinical Outcomes After Opening Wedge High Tibial Osteotomy Kenji Hanada, Michiya Hara, Akira Fujiwara, Hirofumi Hanada, Kazuyoshi Gamada Poster No. 0854 Reliability and Validity of Isometric Knee Flexion and Extension Measurement Using Three Methods of Assessing Muscle Strength Jenny Toonstra, Carl G Mattacola, Christian Lattermann Poster No. 0855 Application of a Clinic-Based Algorithm as a Tool to Identify Female Athletes at Risk for Anterior Cruciate Ligament Injury Helen C Smith, Bruce Beynnon, John Goetschius, Leigh Ann Holterman, Pamela Vacek, Shultz Sandra, Timothy Tourville, Ira Bernstein, James Slauterbeck, Robert Johnson Poster No. 0856 Dominant and non-dominant single-leg landings at different heights: which one is safer among females? Implications for ACL injuries Hossein Mokhtarzadeh, Katie A Ewing, Ina Janssen, Nicholas A Brown, Peter V Lee Poster No. 0857 Effects of Single- and Multi-axis Loading Conditions on ACL Strain: an Indication of ACL Injury Mechanism Ata Kiapour, Constantine K Demetropoulos, Carmen E Quatman, Jason W Levine, Sam Wordeman, Vijay K Goel, Timothy E Hewett Poster No. 0858 A Novel Technique to Simulate Landing Biomechanics: a Cadaveric Model of ACL Injury Ata Kiapour, Carmen E Quatman, Vijay K Goel, Jason W Levine, Sam Wordeman, Timothy Hewett, Constantine K Demetropoulos 98 Poster No. 0859 Representing Intersubject Variability with a Statistical Shape and Alignment Model of the Knee Chandreshwar Rao, James Deacy, Steven Kaschinske, Clare Fitzpatrick, Lorin Maletsky, Paul Rullkoetter, Peter J Laz Poster No. 0860 The Relationship of Joint Line and Flexion/Extension Axes of the Knee to the Mechanical Axis in the Coronal Plane David J Jacofsky, Jerry D’Alessio, Amisha Patel, Mark Kester Poster No. 0861 Posterior Tibial Slopes Measurements Are Not All Alike David B Lipps, Annie M Wilson, James A Ashton-Miller, Edward M Wojtys Poster No. 0862 Tibiofemoral Contact in Landing using Biplane Fluoroscopy-Driven Finite Element Modeling Kevin Shelburne, Azhar Ali, Chadd W Clary, Erik Giphart, Michael Torry, Paul Rullkoetter Poster No. 0863 Elastic Contact and Finite Element Analysis Compared to Experimental Patellofemoral Pressure Measurements Kushal S Shah, Archana Saranathan, Juay Tan, John J Elias Poster No. 0864 Biphasic Finite Element Analysis of the Human Knee joint Hongqiang Guo, Suzanne A Maher, Robert Spilker Poster No. 0865 Computational Biodynamics of Human Knee Joint in Gait Cycle: From Muscle Forces to Cartilage Stresses A. Shirazi-Adl, M. Adouni, R. Shirazi Poster No. 0866 Robot-Based Test Method to Determine Specimen-Specific and JointPosition-Dependent Knee Ligament Kinetics Iris Sauerberg, Eik Siggelkow, Marc Bandi-Muenchinger PS1 Disease Process Hip Poster No. 0867 Dynamic Clinical Assessment of Femoral Acetabular Impingement Preliminary Data Andrew Kraszewski, Anil S Ranawat, Travis Maak, Howard J Hillstrom, Sherry Backus, Bryan Kelly Poster No. 0868 Recruitment and Activity of the Pectineus and Piriformis Muscles During Hip Rehabilitation Exercises: An EMG study Justin Stull, Marc J Philippon, Erik Giphart, Michael Wahoff, Robert LaPrade Poster No. 0869 WITHDRAWN Poster No. 0880 A Japanese family with a novel COL2a1 mutation (c1838G>A) differentiated from idiopathic osteonecrosis of the femoral head Kishiya Masaki, Nakamura Yoshihide, Ohishi Hirotaka, Furukawa KenIchi, Toh Satoshi Poster No. 0871 Radiographic evidence of pincer-type femoroacetabular impingement in patients with end stage hip osteoarthritis Paul Kuzyk, Michael Sellan, Zac Morison, James Waddell, Emil Schemitsch Poster No. 0881 Regulation of Vascular Endothelial Growth Factor (VEGF) Expression by Hypoxia-inducible Factor-1 in the Femoral Head Cartilage Following Ischemia Osteonecrosis Chi Zhang, Yang Li, Reuel Cornelia, Susanne Swisher, Harry Kim Poster No. 0872 Radiographic evidence of cam type femoroacetabular impingement in young patients with end stage hip osteoarthritis Paul Kuzyk, Michael Sellan, Zac Morison, Emil Schemitsch, James Waddell PS1 Gait & Kinematics Poster No. 0873 An Enhanced Discrete Element Analysis Method for Predicting Hip Contact Stresses Christine L Abraham, Steve Maas, Ben J Ellis, Jeff A Weiss, Andrew E Anderson Poster No. 0874 Prognostic Factors Associated with a Subchondral Insufficiency Fracture of the Femoral Head Kenyu Iwasaki, Takuaki Yamamoto, Goro Motomura, Satoshi Ikemura, Ryosuke Yamaguchi, Yukihide Iwamoto Poster No. 0875 Radiological factors affecting joint space narrowing after transtrochanteric anterior rotational osteotomy for stage3 osteonecrosis of the femoral head Garida Zhao, Takuaki Yamamoto, Satoshi Ikemura, Goro Motomura, Kenyu Iwasaki, Ryosuke Yamaguchi, Yukihide Iwamoto Poster No. 0876 The cross over sign is not a reliable diagnostic measure for the assessment of acetabular retroversion Markus O Heller, Georgi I Wassilew, Gerd Diederichs, V. Janz, M. Wenzel, Carsten Perka Poster No. 0877 The Lesion Site and Morphological Characteristics of Transient Osteoporosis of the Hip Ryosuke Yamaguchi, Takuaki Yamamoto, Goro Motomura, Yasuharu Nakashima, Taro Mawatari, Satoshi Ikemura, Kenyu Iwasaki, Garida Zhao, Yukihide Iwamoto Poster No. 0878 The locality of female morphological acetabular disorders Susannah G Clarke, Justin P Cobb, Andrew T Phillips Poster No. 0879 Frequency and Location of Bone Cysts in Hip Osteoarthritis Patients Hiroshi Fujimaki, Yutaka Inaba, Naomi Kobayashi, Yohei Yukizawa, Takashi Ishida, Naoyuki Iwamoto, Hyonmin Choe, Hiroyuki Ike, Taro Tezuka, Yasuhide Hirata, Tomoyuki Saito Posters Poster No. 0870 Finite Element Model of Cam FAI: Examining the Stress Distributions on the Subchondral Bone Geoffrey Ng, Gholamreza Rouhi, Mario Lamontagne, Paul Beaulé Poster No. 0882 Effects of Lower Body Positive-Pressure Exercise on the Lower Extremity Activities, Foot Pressure and Foot Contact Area during Running Natsuka Inoue, Yurie Musya, Toru Fukubayashi Poster No. 0883 Effect of simulated trunk flexion posture on standing and gait Naoki Takeda, Yasuaki Kawamura, Ryouhei Niki, Takumi Kobayashi, Masaki Yamanaka, Tokihumi Majima, Hajime Kamada Poster No. 0884 Quantitative Assessment of Knee Joint Position Sense Takuma Hoshiba, Noritaka Kawashima, Toru Ogata, Toru Fukubayashi Poster No. 0885 The Relationship of the Vector of Quadriceps function to the Femur Osamu Tanifuji, John D Blaha, Shin Kai, Brian J Sabb Poster No. 0886 Effects of Sampling Rates on Knee Kinematics and Kinetics during Single-leg landing Seunghoon Lee, Choongsoo Shin, Yeojeong Kim Poster No. 0887 Kinematic Errors due to Soft Tissue Artifact during a Jump-Cut Maneuver: A Comparison between Optical Motion Capture and Biplanar X-ray Technologies Daniel L Miranda, Michael J Rainbow, Joseph Crisco, Braden C Fleming Poster No. 0888 Quantitative evaluation of dynamic patellar tracking using a digital video system Yuki Fujita, Yasuyuki Ishibashi, Eiichi Tsuda, Yuji Yamamoto, Yuka Kimura, Satoshi Toh Poster No. 0889 Bilateral Transtibial 3D Forces and Moments Monitored During Prolonged Strenuous Activities of Daily Living Christos Mitrogiannis, George Nianios, George Papaioannou Poster No. 0890 The Potential of Accelerometers in the Evaluation of Stability of Total Knee Arthroplasty Humera Khan, Joseph D Zuckerman, James Slover, Frederick F Jaffe, Peter S Walker, Raj J Karia, Joo H Kim 99 Posters Poster No. 0891 A Novel Technique for Knee Kinematics Tracking Using A-Mode Ultrasound: Simulation and Feasibility Study Rimon Tadross, Mohamed Mahfouz Poster No. 0892 Balance Assessment in Joint Hypermobility Syndrome Ian McCarthy, Xiaoyang Hu, Roger Wolman, Helan Cohen, Pria Krishnasamy Poster No. 0893 Stability During Single Limb Squat in Adolescent Females with Patellofemoral Pain Raj Gala, Patrick Carry, Kate Worster, Susan Kanai, Aaron Provance, Nancy Hadley-Miller, James Carollo Poster No. 0894 ACL-deficiency Induces Quadriceps Avoidance in the Uninjured Contralateral Leg During Ambulation Takumi Ino, Yasumitsu Ohkoshi, Yuhei Ohsumi, Tatsunori Maeda, Kou Suzuki, Satoshi Kotake, Hisano Uehara, Toshinori Yoshida, Kensaku Kawakami, Shouzi Suzuki, Kouzi Katou, Masanori Yamanaka, Harukazu Tohyama Poster No. 0895 Novel Intervention Improves Contralateral Knee Function Post-Total Knee Arthroplasty Portia Flowers, Joseph Zeni, Jodie McClelland, David Logerstedt, Lynn Snyder-Mackler Poster No. 0896 Gait Mechanics after Resurfacing Hip Arthroplasty Julien Wegrzyn, Christophe Chevillotte, Rafael Sierra, Robert Trousdale, Kenton Kaufman Poster No. 0897 The influence of gait abnormalities on minimum foot clearance during level walking before and after total hip replacement Andreea Mihai, Markus A Wimmer, Kharma Foucher Poster No. 0901 In Vivo Kinematics of the Talocrural and Subtalar Joints: Comparison of Dorsiflexion and Plantar Flexion in Response to Passive Ankle Rotation Takumi Kobayashi, Masayuki Saka, Hiroki Yamauchi, Eiichi Suzuki, Yoshiharu Kikuchi, Naoto Yamazaki, Kazuyoshi Gamada Poster No. 0902 The Effect of Foot Rotation on Ankle Kinematics and Kinetics during Single Leg Drop Landing Yuuta Koshino, Masanori Yamanaka, Tomoya Ishida, Takumi Kobayashi, Naoki Takeda Poster No. 0903 Ankle Impairment Reductions Post-Stroke with Robotic Rehabilitation Therapy Genna Waldman, Li-Qun Zhang, Richard Harvey, Elliot Roth, YuPeng Ren Poster No. 0904 Validation of Dynamic Pedorthosis in the Treatment of Clubfoot Robert Rizza, XueCheng Liu, John Thometz, Roger Lyon, Channing Tassone, Scott Van Valin Poster No. 0905 The Prevalence and Risk Factors of Radiographic Hallux Valgus Akinobu Nishimura, Ko Kato, Akihiro Sudo Poster No. 0906 Lower Limb Alignment Compensation of Knee Deformity Occurs Through the Subtalar Joint Adam Norton, Annunziato Amendola, Phinit Phisitkul, Steve Liu, Siwadol Wongsak, Catherine Fruehling-Wall, John Callaghan Poster No. 0907 Biplanar Fluoroscopic Measurement of Transverse Tarsal Kinematics In Static Cadaveric Simulated Gait Brad Blankenhorn, Joel Schwartz, Megan Dawson, Jason T Bariteau, Douglas Moore, Christopher DiGiovanni PS1 Foot & Ankle Poster No. 0898 When is the Child’s Foot Matured? Longitudinal Investigation of Foot Loading Patterns between 1 and 10 Years Dieter Rosenbaum, Kerstin Bosch, Todd Pataky Poster No. 0899 Anatomical Landmarks of the Center of the Ankle - An Ultrasonography Study Natsuki Sugimura, Masahiko Ikeuchi, Masashi Izumi, Toshikazu Tani Poster No. 0900 Spinal Reflexive and Corticomotor Fibularis Longus Excitability Predict Self-Reported Function in Patients with Chronic Ankle Instability Brian Pietrosimone, Phillip A Gribble, Michelle McLeod 100 PS1 Infection & Inflammation Poster No. 0908 A Quantitative Analytical Method to Measure Tobramycin in Bone Tissue Elizabeth Novak, Teresa Pekol, Lawrence Andrade, Adam Grenier, Kevor TenHuisen, Joseph Zitelli, Twana Davisson Poster No. 0909 Assessing Pathological Bone Mineralization for Early Detection of Osteomyelitis Karen A Esmonde-White, Francis W Esmonde-White, Crystal Holmes, Michael D Morris, Blake Roessler Poster No. 0910 LL-37: An Effective Cationic Antimicrobial Peptide against Intra- and Extra-Cellular Bacteria Bingyun Li, Jabeen Noore, Sara Kurian, Adly Noore Poster No. 0912 Measuring the Bacterial Adherence to Silver Composite PEEK Materials David Jaekel, Helen Davidson, Noreen Hickok, Steven M Kurtz Poster No. 0913 Antibacterial and Osteogenic Properties of Silver Incorporated Bioactive Glass Kristi L Reuss, Sonny Sheth, Marissa Darmoc, Theodore Clineff Poster No. 0914 Intraoperative surveillance of contamination does not predict deep prosthetic infection Nobuyuki Miyazaki, Shinji Minami, Ryosuke Sakata, Takaya Taniguchi, Naoya Mine, Wataru Taniguchi, Yusuke Miyake, Munehito Yoshida Poster No. 0915 Clinical Performance of Retrieved Dynamic and Static Knee Antibiotic Cement Spacers David Jaekel, Gregg Klein, Judd Day, Harlan Levine, Javad Parvizi, Mathew Austin, Steven M Kurtz Poster No. 0916 Hydrophobic Polycationic Coatings that Inhibit Biofilm Formation on Orthopedic Implants and Support Bone Healing During Infection in Sheep Thomas P Schaer, Suzanne Stewart Poster No. 0917 Prevention of Pin Tract Infection in External Fixation using Bactericidal Sol-Gel Thin Films in vivo Haibo Qu, Christin Knabe, Shula Radin, Jonathan P Garino, Paul Ducheyne Poster No. 0918 In vitro Testing of Adult Mesenchymal Stem Cells as an Adjunct Therapy for Treating Periprosthetic Joint Infections Antonia F Chen, Rocky S Tuan Poster No. 0919 Staphylococcus aureus Internalization and Associated Osteoblast Responses Therwa Hamza, Bingyun Li Poster No. 0920 Different sensitivity and specificity of real-time polymerase chain reaction and histopathological evaluation in diagnosing periprosthetic infection Yushi Miyamae, Yutaka Inaba, Naomi Kobayashi, Hyonmin Choe, Hiroyuki Ike, Takako Momose, Shusuke Fujiwara, Tomoyuki Saito Poster No. 0921 Al and O Ion Implantation to Suppress Bacterial Adhesion on Biodegradable Mg-Y-Re Alloy Ying Zhao, Mark T. L. Li, Guosong Wu, Paul K. Chu, Kelvin W.K. Yeung Poster No. 0922 Limited Value of Sonication & Molecular Methods to Diagnose Infection at Revision Hip & Knee Arthroplasty Riku Hayashi, Marion J Tuohy, Viktor Krebs, Robert Molloy, Geraldine Hall, Gary W Procop, Thomas W Bauer Poster No. 0923 Increasing the Elution of Vancomycin from High Dose Antibiotic Loaded Bone Cement: A Novel Preparation Technique Tanay J Amin, Kelly J Hendricks, Terence E McIff Posters Poster No. 0911 A Novel Method of Quantifying Internalized Staphylococcus aureus Helen M Davidson, Ryan A Shenck, Alexander R Horswill, Noreen Hickok Poster No. 0924 The Development of a Broad Spectrum Antimicrobial Device Coating for the Prevention of Resistant Strain Bacterial Infections Kristofer D Sinclair, Ryan Farnsworth, Theresa Pham, Dustin Williams, Catherine Loc-Carrillo, Roy D Bloebaum Poster No. 0925 MRI can be used to detect Antimicrobials in Orthopaedic Wounds Morgan Boresi, Alex McLaren, Michael Caplan, Chris Estes, Ryan McLemore PS1 Trauma Poster No. 0926 Non-Invasive NIRS Versus Invasive Direct Pressure Monitoring of Acute Compartmental Syndrome in a Porcine Model Curtis Cathcart, Michael Shuler, Brett Freedman, Lisa Reynolds, Amy Cole, Steven Budsberg Poster No. 0927 A Canine Model for Measuring Tissue Oxygenation as a Diagnosis of Compartment Syndrome Heejae Kang, James Mok, Erik Hansen, Utku Kandemir, Mark Rollins, Givenchy Manzano, Xuhui Liu, Hubert Kim Poster No. 0928 Examination of Genetic Variants for Skeletal Muscle Damage: A Functional Genetic Variant in the PAC1 Gene may predict Physical Stress Clare E Griffis, Heather Gordish-Dressman, Eric P Hoffman, Priscilla M Clarkson, Joseph M Devaney, Laura L Tosi Poster No. 0929 A Novel Trauma Induced Mouse Heterotopic Ossification Model Xuhui Liu, Bernard Halloran, Robert Nissenson, Olle Larm, Lars Adolfsson, Hubert Kim Poster No. 0930 Reduction of Fracture Risks and Fall Incidences in Community Elderly by Low-Magnitude, High-Frequency Vibration Treatment --- A Prospective Randomized Clinical Trial Kwok Sui Leung, Chi Yu Li, Som Yu Chan, Lin Qin, Wing Hoi Cheung Poster No. 0931 The Incidence of Compartment Syndrome after Flexible Nailing of Pediatric Tibial Shaft Fractures Nirav K Pandya, Eric W Edmonds 101 PS1 Total Hip Replacement - General Posters Poster No. 0932 Low Vitamin D Status Does Not Adversely Affect Short-Term Functional Outcome After Total Hip Arthroplasty Aasis Unnanuntana, Anas Saleh, Jeffery E Mait, Andre D Shaffer, Joseph T Nguyen, Charles N Cornell, Thomas P Sculco, Carol A Mancuso, Joseph M Lane Poster No. 0933 Wearable Sensor for Inpatient Activity Monitoring to Improve Arthroplasty Recovery Programs Simon van Laarhoven, Matthijs Lipperts, Rachel Senden, Wim van Asten, Ide C Heyligers, Bernd Grimm Poster No. 0934 Factors that Influence Patient Selection of an Orthopaedic Surgeon and Hospital Kevin Bozic, Vanessa Chiu, David Kaufman, Stephanie Caminiti, Courtland Lewis Poster No. 0935 Performance-Based Tests and Self-reported Questionnaires Provide Distinct Information on Functional Recovery after Total Hip Arthroplasty Aasis Unnanuntana, Anas Saleh, Jeffrey Mait, Andre D Shaffer, Charles N Cornell, Thomas P Sculco, Carol A Mancuso, Joseph M Lane Poster No. 0936 Major And Minor Complications Following Minimally Invasive Anterior Approach With Fracture Table For Total Hip Arthroplasty Stefan Kreuzer, Azim Karim Poster No. 0937 Predicting Difficulty of Femoral Exposure Through Radiographic Analysis in the Direct Anterior Approach for Total Hip Arthroplasty Azim Karim, Kevin Leffers, Stefan Kreuzer Poster No. 0938 Spinal Balance in the Coronal Plane after Total Hip Arthroplasty Takashi Ishida, Yutaka Inaba, Naomi Kobayashi, Kyohei Murakami, Naoyuki Iwamoto, Yohei Yukizawa, Hyonmin Choe, Chie Aoki, Hiroyuki Ike, Hiroshi Fujimaki, Taro Tezuka, Yasuhide Hirata, Takako Momose, Yushi Miyamae, Haruka Suzuki, Masamitsu Tomioka, Tomoyuki Saito Poster No. 0939 Genetic Variation in Inflammasome and Bone Turnover Pathways and Risk of Heterotopic Ossification following Total Hip Arthroplasty Scott J MacInnes, Elena Del Vescovo, Andrew Gordon, J. Mark Wilkinson 102 Poster No. 0942 Component positions affect in vivo stability of Total Hip Arthroplasty Hiromasa Tanino, Hiroshi Ito, Yasuhiro Nishida, Yasuhiro Yamanaka, Toshiki Nakamura, Takeo Matsuno Poster No. 0943 Comparison of continuous femoral nerve block with and without combined sciatic nerve block after total hip arthroplasty: a prospective randomized study Shoji Nishio, Juichi Miura, Yuki Fujihara, Shigeo Fukunishi, Tomokazu Fukui, Shinichi Yoshiya Poster No. 0944 Is 2D Cup Coverage Measurement in Total Hip Arthroplasty with Developmental Dysplasia of the Hip Accurate? A. Thoreson, L. Wang, R. Trousdale, K. Dai, K. An, B. Morrey Poster No. 0945 Is dislocation rate increasing after bipolar hemiarthroplasty in patients with neuromuscular diseases? Kuen Tak Suh, Dae Woong Kim, Hong Seok Lee, Jung Sub Lee Poster No. 0946 Does the Use of Antidepressants Predict Outcomes Following Total Hip Replacement Surgery? Meridith Greene, Ola Rolfson, Max Gordon, Henrik Malchau, Göran Garellick Poster No. 0947 Lower preoperative hip adduction moments are associated with greater clinical and biomechanical recovery after total hip replacement Kharma Foucher, Markus Wimmer Poster No. 0948 Changes in pelvic tilt after total hip arthroplasty : three-dimensional analysis Haruka Suzuki, Yutaka Inaba, Naomi Kobayashi, Kyohei Murakami, Yohei Yukizawa, Takashi Ishida, Hyonmin Choe, Hiroyuki Ike, Shusuke Fujiwara, Masamitsu Tomioka, Tomoyuki Saito Poster No. 0949 The Validity of Using Administratively Coded Comorbidity and Complication Data in TJA Kevin Bozic, Ravi Bashyal, Shawn Anthony, Vanessa Chiu, Brandon Shulman, Harry Rubash Poster No. 0940 Long Term Follow-Up of Cementless THR for the Treatment of Osteonecrosis: Have We Improved Compared to Cemented THR? John Callaghan, Nicholas Bedard, Steve Liu, Richard Johnston Poster No. 0950 Measuring impact loads by surgical hammers: A study involving insertion of smooth pins into polyurethane Stacey R Hildebrand, Shawn K Wiebe, Jason Morrison, Colin J Burnell, Thomas R Turgeon, Martin J Petrak Poster No. 0941 Perceived Leg Length Discrepancy after Total Hip Arthroplasty Takako Momose, Yutaka Inaba, Naomi Kobayashi, Taro Tezuka, Hyonmin Choe, Hiroyuki Ike, Yushi Miyamae, Shusuke Fujiwara, Tomoyuki Saito Poster No. 0951 Experimental Analysis of the Thermal Effects of Surgical Bone Cutting Eimear Dolan, Conor Casey, Laoise M McNamara Poster No. 0952 Intermittent Bolus Administration of Intra-articular Analgesics after Total Knee Arthroplasty Masahiko Ikeuchi, Yuko Kamimoto, Masashi Izumi, Natsuki Sugimura, Mizue Takemura, Kayo Fukunaga, Masataka Yokoyama, Toshikazu Tani Poster No. 0953 Outcome of Total Knee Arthroplasty in Obese Patients Chin Tat Lim, Puang Huh Bernard Lau, Heng Hee Li, Lingaraj Krishna Poster No. 0954 Predicting Need for Allogeneic Transfusion Following Total Knee Arthroplasty William Macaulay, Manish Noticewala, Wenbao Wang, Jonathan Nyce, Jeffrey Geller Poster No. 0955 WITHDRAWN Poster No. 0956 Multi-ADL Profiles in TKR Wear Testing Help Discriminate Between Wear Theories Anthony M Strickland, Mark Taylor Poster No. 0957 Tibial spines of retrieved PS knees show paradoxical height increase John H Currier, Alissa Santa Maria, Meagan Tibbo, Evan Carlson, Douglas W Van Citters Poster No. 0958 The Effect of Insert Conformity on The Wear of Total Knee Replacements Abdellatif Abdelgaied, Claire Brockett, Feng Liu, Louise Jennings, John Fisher, Zhongmin Jin Poster No. 0959 Wear of a Total Knee Replacement with Antioxidant UHMWPE and Gradually Varying Sagittal Curvature Matt Dressler, Steve Swope, Jennifer Tikka, Catherine Hardaker, Mark Heldreth, Todd D Render Poster No. 0960 Crossing the 8-mm Threshold: Can Sequentially Cross-Linked Tibial Inserts Cross the Barrier? Laryssa A Korduba-Rodriguez, Siraj A Sayeed, Aaron Essner, Aaron J Johnson, Ronald E Delanois, Michael A Mont Poster No. 0961 Effect of Simulated Intraoperative Damage of Oxidized Zirconium Knee Femoral Components on Polyethylene Wear Ramprasad Papannagari, Ray Bond, Jeff Sprague PS1 Arthroplasty - Osteolysis Wear Debris Poster No. 0962 Progression of Periacetabular Osteolytic Lesions Donald W Howie, Susan Neale, Roumen Stamenkov, David M Findlay Poster No. 0963 Immunophenotypic Changes in Peripheral Blood Lymphocytes from Patients with Failed Hip Implants Ian Hurda, Paul Beaulé, Isabelle Catelas Poster No. 0964 Speciation and Distribution of Cobalt and Chromium in Osteoblasts and Osteoclasts using Microfocus X-ray fluorescence & X-ray Absorption Near-Edge Structure Karan Shah, Paul Quinn, J. Mark Wilkinson, Alison Gartland Posters PS1 Total Knee Replacement - General/ Wear Poster No. 0965 Statins may reduce femoral osteolysis in patients with total hip arthroplasty Anne Lübbeke, Guido Garavaglia, Christophe Barea, Alexis Bonvin, Constantinos Roussos, Pierre Hoffmeyer Poster No. 0966 Genetic Variation in Inflammasome Signaling and Bone Turnover Pathways and Risk of Osteolysis after Total Hip Arthroplasty Elena Del Vescovo, Scott J MacInnes, William E Ollier, Peter R Kay, Edward M Greenfield, J. Mark Wilkinson Poster No. 0967 Metal Ions Upregulate Vascular Activation, Lymphocyte Trafficking, and Angiogenesis: Potential Non-Allergic Mechanisms for the Tissue Responses to Metal on Metal Articulations in Total Joint Arthoplasty James T Ninomiya, Scott A Kuzma, T. J Schnettler, J. G Krolikowski, Janine A Struve, Dorothee Weihrauch Poster No. 0968 Exogenous MC3T3 Pre-osteoblasts Migrate Systemically and Mitigate Wear Particle-induced Bone Loss Kate Fritton, Pei-Gen Ren, Ting Ma, Emmanuel Gibon, Sandip Biswal, Sanjiv Gambhir, Stuart B Goodman Poster No. 0969 Metal-Activated Primary Human Lymphocytes Can Induce Osteoclastogenesis In Vitro Phil Glivar, Jessica Yadav, Kyron McAllister, Marco Caicedo, Nadim J Hallab Poster No. 0970 Diacylglycerol Kinase (DGK) Signal-Pathway in Periprosthetic Aseptic Loosened Total Hip Arthroplasty Yasunobu Tamaki, Tomoyuki Hirayama, Yuya Takakubo, Kan Sasaki, Hiroshi Hasegawa, Kiyoshi Iwazaki, Yasushi Naganuma, Kaoru Goto, Michiaki Takagi Poster No. 0971 Zirconium-Alloy and Zirconium-Oxide Particles Produce less Toxicity and Inflammatory Cytokines than Cobalt-Alloy and TitaniumAlloy Particles In Vitro, in Human Osteoblasts, Fibroblasts and Macrophages Nadim J Hallab, Kyron McAllister, Joshua J Jacobs, Vivek Pawar Poster No. 0972 TRAP 5b is a bone marker for early detection of implant loosening in an osteopenic animal model Andreas A Kurth, David Steindl, Panos Diaremes, Björn Habermann, Konstantinos Kafchitsas 103 PS1 Arthroplasty - Implant Fixation Posters Poster No. 0973 Detection of Sound Vibrations for Monitoring Aseptic and Septic Loosening of Total Hip Stems Catherine Ruther, Ulrich Timm, Hartmut Ewald, Wolfram Mittelmeier, Rainer Bader, Daniel Kluess Poster No. 0974 Towards a more realistic prediction of peri-prosthetic micro-motions Nico Verdonschot, Bas van der Ploeg, Maria Tarala, Jasper Homminga, Dennis Janssen Poster No. 0975 The Influence of Coating Length on Osseointegration of Uncemented Implants: A Computational Study Pramod Kumar Puthumanapully, Martin Browne Poster No. 0976 Revision Reasons and Bone Ingrowth in Retrieved Porous Tantalum Acetabular Shells and Femoral Stems Judd S Day, Josa A Hanzlik, Gregg R Klein, Harlan Levine, Mark A Hartzband, Javad Parvizi, Matthew J Kraay, Clare M Rimnac, Steven M Kurtz Poster No. 0977 Lubricin and α-Smooth Muscle Actin-Containing Myofibroblasts in the Pseudomembrane Around Loose Hip and Knee Prostheses Thomas Cheriyan, John E Ready, Greogory W Brick, Scott D Martin, Thomas M Schmid, Robert F Padera, Myron Spector Poster No. 0978 Dynamic implant cut-out is governed by peri-implant bone microstructure Samuel E Basler, John Traxler, Ralph Müller, Harry van Lenthe Poster No. 0979 Calcium Based Fillers Promote Bone Defect Healing Around Porous Titanium Implants Letitia Lim, John D Bobyn, Miekella J Okyere, Jake E Barralet, Kristian M Bobyn, Michael Tanzer Poster No. 0980 Adherent Lipopolysaccharide Inhibits Osseointegration In Vivo Lindsay Bonsignore, Joscelyn Tatro, Victor Goldberg, Edward Greenfield Poster No. 0981 Why is Titanium Biocompatible? Fereydoon Namavar, Renat F Sabirianov, Denes Marton, Alexander Rubinstein, Kevin Garvin Poster No. 0982 Comparison of Bone Ingrowth into Two Different Porous Metals in a Canine Implantable Chamber Scott Hadley, Ronald D Howell, Sean Thompson, Eric Eisemon, John L Ricci, Renwen Zhang, William Jaffe, Sally Frenkel Poster No. 0983 BoneMaster HA coating shows short term in vivo resorption and may assist with early implant fixation Gautam Gupta 104 Poster No. 0984 Zolendronate impregnated allograft improves the biomechanical fixation of experimental revision-implants Mette Sorensen, Jørgen Baas, Jeppe Barckman, Joan E Bechtold, Kjeld Soballe Poster No. 0985 Impregnation of bone chips with alendronate and cefazolin, combined with demineralized bone matrix: a bone chamber study in goats Nina Mathijssen, Gerjon Hannink, Peter Pilot, Willem Schreurs, Rolf Bloem, Pieter Buma Poster No. 0986 A model of microvasculature in periprosthetic healing Georges Khalil, Pierre Mansat, Pascal Swider Poster No. 0987 A New Approach to Quantify Trabecular Resorption Adjacent to Cemented Knee Arthroplasty Kenneth Mann, Mark A Miller, Caitlin Pray, Nico Verdonschot, Dennis Janssen Poster No. 0988 Implant Migration and Peri-prosthetic Bone Quality of Uncemented Tibial Base Plates with or without Screw Fixation Elise Laende, Allan Hennigar, Michael Gross, John Amirault, Michael Dunbar PS1 Total Knee Replacement - Kinematics Poster No. 0989 Potential risk for excising the popliteus tendon femoral footprint in primary total knee arthroplasty Atsushi Takahashi, Mitsuhiro Kashiwaba, Daisuke Chiba, Takashi Aki, Takehiko Sugita, Eiji Itoi Poster No. 0990 Intraoperative Passive Flexion Kinematics of Osteoarthritic Knees before and after Mobile Bearing PCR-TKA Daisuke Seino, Fumiaki Imamura, Hiroshi Nakayama, Takatoshi Morooka, Shinichi Yoshiya Poster No. 0991 Anatomical Landmarks of the Distal Tibia and the Flexion-Extension Axis of the Knee M. Griffin, S. K Ismaily, W. Tri, A. Suarez, P. C Noble Poster No. 0992 Posterior-stabilized knee could improve kinematics by mimicking convexly lateral tibial plateau Yu-Liang Liu, Wen-Lin Yeh, Wen-Chuan Chen, Kun-Jhih Lin, Cheng-Kung Cheng Poster No. 0993 A Novel and Reproducible Reference Axis that Indicates Axial Rotation of Distal Tibia Hiroyuki Enomoto, Takayuki Nakamura, Hiroshi Shimosawa, Akeo Waseda, Yoshiaki Toyama, Yasunori Suda Poster No. 0995 Operative Technique Affected The Intra-operative Joint Kinematics Of Total Knee Arhtroplasty Yukihide Minoda, Shigeru Nakagawa, Yoshinori Kadoya, Akio Kobayashi, Kazuhide Tomari, Makoto Kondo, Iwaki Hiroyoshi, Mitsuhiko Ikebuchi, Taku Yoshida, Yoshio Matsui, A. Sumitomo, Ryo Sugama, Shigekazu Mizokawa, Y. Higuma, T. Noguchi, M. Hirakawa, Hiroaki Nakamura Poster No. 0996 Does Patellar Resurfacing Affect Patello-Femoral Kinematics in Total Knee Replacement? An in-vitro study Claudio Belvedere, Andrea Ensini, Alberto Leardini, Alessandro Feliciangeli, Harald Boschert, Sandro Giannini Poster No. 0997 Initial Results Of A Modified Flexion/Extension Gap Balancing Technique Using Soft Tissue Force Measurements In Total Knee Arthroplasty Azim Karim, Stefan Kreuzer Poster No. 0998 Tibio-Femoral Kinematics in Several TKA Designs During a Loaded Squat Silvia Pianigiani, Luc Labey, Walter Pascale, Bernardo Innocenti Poster No. 0999 Shape Analysis of the Tibiofemoral Joint Pat Courtis, Stephanie Quinn, Mark Heldreth, David FitzPatrick Poster No. 1000 Influence of intraoperative soft tissue balance on knee kinematics in cruciate-retaining total knee arthroplasty Tokio Matsuzaki, Tomoyuki Matsumoto, Seiji Kubo, Hirotsugu Muratsu, Takehiko Matsushita, Hiroshi Sasaki, Shinya Oka, Yuichiro Nishizawa, Masahiro Kurosaka, Ryosuke Kuroda Poster No. 1004 Quantitative Investigation of Implant Placement Using a Portable CMM Nick Oblizajek, Amitkumar Mane, Fred Wentorf Poster No. 1005 Intra-specimen and Surgical Technique Variations and the Morphology of the Tibial Resection Plane Henry Ran, Alexander Suarez, Sabir K Ismaily, Philip C Noble Posters Poster No. 0994 Tibio-femoral Kinematics Change with Distraction and Release of the Cruciate Ligaments J. M DePasse, S. Sharma, D. Daylamani, J. E Gold, S. Ismaily, P. C Noble Poster No. 1006 Chronologic Changes in Flexion Gap Asymmetry after TKA - Comparison between Intra-operative Measurement and Postoperative Radiographic Assessment of Flexion Gap Ryuichi Gejo, Hiraku Motomura, Isao Matsushita, Kazuhito Sugimori, Hiroki Watanabe, Yoshiaki Ito, Tomoatsu Kimura Poster No. 1007 Asymmetric Femoral Component Design is Preferable for the Patellofemoral Contact Configuration in Total Knee Arthroplasty Shinya Kawahara, Shuichi Matsuda, Ken Okazaki, Yasutaka Tashiro, Hiroyuki Nakahara, Shigetoshi Okamoto, Kazutaka Nishikawa, Yukihide Iwamoto Poster No. 1008 Kinematic comparison of fixed-and mobile-bearing total knee arthroplasty in vivo Toshifumi Watanabe, Masafumi Ishizuki, Takeshi Muneta, Nicholas Dunbar, Alex Iorgulescu, Scott A Banks Poster No. 1009 What We Can and What We Can’t Learn from Minimum Twenty-Year Follow-Up Studies of Total Knee Replacement John Callaghan, David Hennessy, Mitchell Beckert, Steve Liu, Devon Goetz, Scott Kelley, Richard Johnston Poster No. 1010 Numerical Analysis of Stem Length and Fixation Technique in a Hinged Total Knee Arthroplasty Susanne Fuchs-Winkelmann, Bilal El-Zayat, Thomas J Heyse, Nelson Fanciullacci, Yan Chevalier, Bernardo Innocenti Poster No. 1001 Soft Tissue Balancing of TKA Post Mortem Retrievals William M Mihalko, Jason A Lindsey, Devin Conner, David Knox, John L Williams Poster No. 1011 ISO Knee Testing Fails to Reproduce the Loads and Moments Imposed on the Knee by Active Patients T. C Borden, H. L Jones, P. C Noble Poster No. 1002 Sequential-Biplane Radiography for Measuring Pre and Post Total Knee Arthroplasty Kinematics Gulshan B Sharma, Stefan K Saevarsson, Shahram Amiri, Spencer Montgomery, Heiko Ramm, Derek Lichti, Stefan Zachow, Carolyn Anglin Poster No. 1012 A newly post-cam mechanism of PS TKA designed to improve knee kinematics Kun-Jhih Lin, Chia-Che Lee, Chang-Hung Huang, Yu-Liang Liu, WenChuan Chen, Cheng-Kung Cheng Poster No. 1003 Is Cruciate-Ligament Functionality Retained in Partial and Multicompartmental Knee Arthroplasty? Toshifumi Watanabe, Stefan Kreuzer, Kevin Leffers, Michael Conditt, Jennifer Jones, Nicholas Dunbar, Alex Iorgulescu, Scott A Banks Poster No. 1013 Knee Pose and Geometry Pre- and Post-Total Knee Arthroplasty Using Computed Tomography Gulshan B Sharma, Karen C Ho, Stefan K Saevarsson, Heiko Ramm, Robert Lieck, Stefan Zachow, Carolyn Anglin 105 Posters Poster No. 1014 InVivo Kinematics after the ADVANCE Medial Pivot TKA -7years results Takaaki Tanaka, Yoshio Kumagae, Masaaki Chazono, Tomoaki Sai Poster No. 1015 Malpositioning of Tibial Trays in TKR: The Effect of Implant Asymmetry P. N Ramkumar, C. Cookston, S. K Ismaily, J. E Gold, C. Lawrie, K. Mathis, P. C Noble PS1 Arthroplasty - Finite Element Analysis/Hip Poster No. 1016 An xFEM Approach to fracture of Compact Bone with Intracortical Porosity Silke Besdo, Deepak Vashishth Poster No. 1017 Clinical Estimation of Proximal Femur Stiffness and Strength using Finite Element Analysis Rachel Entwistle, Sean McEligot, Kevin Bennet, L. Joseph Melton, Sundeep Khosla, Shreyasee Amin, Dan Dragomir-Daescu Poster No. 1018 Nonlinear Finite Element Analysis of the Human Proximal Femur Shashank Nawathe, Ben Roberts, Mary Bouxsein, Panayiotis Papadopoulos, Tony M Keaveny Poster No. 1019 Accuracy of in vivo μMRI-based biomechanics of the proximal femur: a simulation study Maite Aznarez-Sanado, Chamith S Rajapakse, Ning Zhang, Wenli Sun, Jeremy F Magland, Alex C Wright, Felix W Wehrli Poster No. 1020 Hexahedral vs. Tetrahedral Finite Element Models of the Proximal Femur Vishwas Mathur, Dan Dragomir-Daescu Poster No. 1021 Finite Element Models of the Proximal Femur: Changing CT Settings and Meshing Strategy Christina Salas, Dan Dragomir-Daescu Poster No. 1022 Effect of Image Resolution on the Accuracy of Trabecular Morphology and the Convergence Behavior of Micro-CT Finite Element Models of Mouse Bone Varun Bhatia, W. B Edwards, Karen Troy Poster No. 1023 Changes in Bone Mineral Density and Equivalent Stress after Total Hip Arthroplasty Hiroyuki Ike, Yutaka Inaba, Naomi Kobayashi, Yasuhide Hirata, Kyohei Murakami, Yohei Yukizawa, Hyonmin Choe, Haruka Suzuki, Masamitsu Tomioka, Tomoyuki Saito Poster No. 1024 Bone Remodeling after Total Hip Arthroplasty with a Metaphyseal Loading Implant. Finite Element Analysis and Validation by DualEnergy X-ray Absorptiometry Matthias Lerch, Agnes Kurtz, Christina Stukenborg-Colsman, Ingo Nolte, Nelly Weigel, Bernd Behrens, Anas Bouguecha 106 Poster No. 1025 Bone-on-Bone vs. Implant Impingement in Large Diameter Total Hips Jacob Elkins, Douglas R Pedersen, John J Callaghan, Thomas Brown PS1 Polyethylene Wear - UHMWPE Poster No. 1026 WITHDRAWN Poster No. 1027 Cross-shear and Rolling/Sliding Wear of Ultra-High Molecular Weight Polyethylene Eli W Patten, Michael D Ries, Lisa A Pruitt Poster No. 1028 WITHDRAWN Poster No. 1029 Biological Effects of different polyethylene wear particles on articular cartilage in vivo Sandra Utzschneider, Verena Lorber, Birte Sievers, Alexander Paulus, Christian Schröder, Volkmar Jansson Poster No. 1030 Quantification of Rim Notching from Micromotion in Retrieved Polyethylene Acetabular Liners Matthew Teeter, Nicholas Paterson, Steven MacDonald, James Howard, Richard McCalden, Douglas Naudie Poster No. 1031 Wear of highly cross-linked polyethylene in large articulations: A randomised trial using RSA Donald W Howie, Stuart A Callary, Oksana T Holubowycz Poster No. 1032 Effect of Contact Geometry and Contact Area on Wear of UHMWPE Elizabeth Hippensteel, Matt Dressler, Todd Render, Cath Hardaker Poster No. 1033 In Vivo Performance of Second Generation Highly Cross-linked UHMWPE Shannon Rowell, Brad Micheli, Keith Wannomae, Henrik Malchau, Orhun K Muratoglu, Jiaqing Yi Poster No. 1034 Network Parameters of UHMWPE before and after γ-Irradiation Eduardo Abreu, Anuj Bellare Poster No. 1035 Squalene Oxidizes Polyethylene through the Generation of Hydroperoxides Mitchell Fung, Orhun K Muratoglu, Ebru Oral Poster No. 1036 Load Dependent Tribochemical Reactions Minimize Wear from CoCrMo Alloy Markus A Wimmer, Mathew T Mathew, Michel P Laurent, Chris Nagelli, Yifeng Liao, Laurie Marks, Alfons Fischer, Joshua J Jacobs Poster No. 1037 A New Process to Increase the Ultimate Tensile Properties of Radiation Crosslinked Polyethylene Hung Ngo, Anuj Bellare Poster No. 1039 Properties of Highly Crosslinked UHMW Polyethylene with Annealing after Five-Year-Shelf-Storage in N2 gas Kenji Kawate, Ikuo Kawahara, Mitsuru Munemoto, Katsuya Tamai, Tomoyuki Ueha, Yoshinobu Uchihara, Kazuya Takemura, Seiichi Ono, Yasuhito Tanaka Poster No. 1040 Comparison of the In Vivo Performance of Two Highly Crosslinked Ultra High Molecular Weight Polyethylene Materials in the Hip and Knee Steven D Reinitz, Katherine J Franklin, Laura T Gray, Harold S Dansu, Barbara H Currier, Douglas W Van Citters Poster No. 1041 Experimental Investigation and Numerical Modeling of Nonmonotonic Creep Behavior of UHPWPE Used in Orthopedic Implants Fazeel Khan, Colin Yeakle, Said Gomaa PS1 Arthroplasty - Finite Element Analysis Knee Poster No. 1042 Optimizing Knee Femoral Component Strength and Bone Preservation with Finite Element Analysis John E Slamin, Ray Bojarski, Bob Ketelhohn, Brian Parsley Poster No. 1043 Investigation of a Reversed Materials Early Intervention Implant for Medial Osteoarthritis of the Knee Miriam Chaudhary, Peter S Walker, Joseph Bosco, Ivan J FernandezMadrid Poster No. 1044 Improving Dynamic Mid-stance Stability: An Experimental and Finite Element Study Chadd W Clary, Clare K Fitzpatrick, Lorin P Maletsky, Paul J Rullkoetter Poster No. 1045 Population based finite element study of the effect of under sizing a cementless tibial tray on primary stability Francis Galloway, Prasanth B Nair, Mark Taylor PS1 Total Hip Replacement - Implant Poster No. 1046 Taper junction metal ion release in large diameter metal on metal modular devices Amir Kamali, Joseph Pamu, Jasper Daniel, Chenxi Li, Roger Ashton, Azad Hussain Poster No. 1047 Angular mismatch influences micromotion at the stem-neck taper of a bimodular hip prosthesis during activities of daily living Sabrina Y Jauch, Gerd Huber, Henning Haschke, Kay Sellenschloh, Thomas M Grupp, Michael M Morlock Poster No. 1048 Strength of the taper lock at the stem-neck junction in hip replacement Annelie Rehmer, Nicholas E Bishop, Kay Sellenschloh, Michael M Morlock Poster No. 1049 A taper interface examination of sixty large diameter metal-on-metal modular hip retrievals Amir Kamali, Chenxi Li Poster No. 1050 Are Fretting and Corrosion Reduced in Contemporary Head/Neck Modular Junctions? Robert M Urban, Deborah J Hall, Jeremy L Gilbert, Erica L Dahlmeier, Jennifer L Wright, Craig J Della Valle, Jorge O Galante, Joshua J Jacobs Posters Poster No. 1038 WITHDRAWN Poster No. 1051 Comparison of the immediate post-operative stability of a novel tapered hip stem to a predicate design Amos Race, Thies Wuestemann, Dermot Collopy Poster No. 1052 Postoperative Evaluation of Load Transfer on the Cementless Hip Stem Using Patient-specific Finite Element Analysis Go Yamako, Etsuo Chosa, Xin Zhao, Koji Totoribe, Shinji Watanabe, Takako Ishii, Nobutake Nakane Poster No. 1053 A Novel Test Method to Characterize Intraoperative Impacts during Femoral Broaching and Stem Insertion Laura Yanoso-Scholl, Mayur Thakore, Gregg Schmidig, Robert Truppner, Meg Smith Poster No. 1054 Medium and long term results of cemented double tapered polished stems in patients younger than 40 Lucian B Solomon, Kerry Costi, Andrew MacDonald, Margaret A McGee, Susan Pannach, Donald W Howie Poster No. 1055 Native Anatomy in Primary Hip Osteoarthritis Does it Match Recommendations for “Safe” Component Orientation in THA? Christian Merle, George Grammatopoulos, Elise C Pegg, Hemant Pandit, Peter R Aldinger, David W Murray, Harinderjit S Gill Poster No. 1056 Measuring acetabular component anteversion after total hip arthroplasty: CT or Plain Radiographs? Benjamin McArthur, Michael B Cross, Christina Geatrakas, Joseph Nguyen, Bernard Ghelman, David J Mayman Poster No. 1057 Torsional Forces Generated in Press-Fit Acetabular Shells with Fixed and Dual Mobility Bearing Insert Designs Lokesh Kumar Raja, Laura Scholl, Gregg Schmidig, Christopher Heffernan, Mayur Thakore, Jim Nevelos, Paul Perona Poster No. 1058 Kinematics and Coronal Plane Stability Between a Posterior Stabilized vs Bicruciate Stabilized vs Ultracongruent Total Knee Arthroplasty Michael B Cross, Christopher Plaskos, Denis Nam, Claus Egidy, Joseph Nguyen, Xiaowei A Li, Stephen Lyman, Andrew Pearle, David J Mayman 107 PS1 Implant - Uni-Knee Replacement Posters Poster No. 1059 Unicomparmental Knee Arthroplasty Relieves Pain and Improves Function More Than Total Knee Arthroplasty William Macaulay, Manish Noticewala, Jeffrey Geller, Jonathan Lee Poster No. 1060 An Active Shape Modeling Based Tool for Semi-automated Xray Assessment Elise C Pegg, Hemant Pandit, Christopher A F Dodd, David W Murray, Harinderjit S Gill Poster No. 1061 Does Anterior Cruciate Ligament Deficiency Preclude Unicompartmental Knee Replacement? Adam Boissonneault, Hemant Pandit, Elise Pegg, Cathy Jenkins, Christopher Dodd, David Murray, Max Gibbons Poster No. 1062 Comparison of Natural and Unresurfaced Patellofemoral Mechanics James Deacy, Clare Fitzpatrick, Peter J Laz, Paul Rullkoetter Poster No. 1063 Regional Variation In Lateral Compartment Articular Cartilage to Augment Guidelines For Unicompartmental Knee Replacement Susannah Gilbert, Suzanne A Maher, Michelle Perna, Jad Bou Monsef, Friedrich Boettner PS1 Hip/Knee Arthroplasty - Surgical Navigation & Robotics Poster No. 1064 Validation of the Femoral Component Placement during Hip Resurfacing between the Conventional Jigs, Custom-made Template, and CT-based Navigation Makoto Kitada, Takashi Sakai, Toshihisa Hanada, Tsuyoshi Murase, Nobuo Nakamura, Nobuhiko Sugano Poster No. 1065 A Comparison between 2D and 3D Digital Templating for Resurfacing Hip Arthroplasty Satoshi Nakasone, Masaki Takao, Takashi Nishii, Takashi Sakai, Nobuo Nakamura, Nobuhiko Sugano Poster No. 1066 Analysis of Risk factors affecting the accuracy of the image-free THA navigation system in determination of acetabular cup orientation Tomokazu Fukui, Shigeo Fukunishi, Shoji Nishio, Yuki Fujihara, Shohei Okahisa, Shinichi Yoshiya Poster No. 1067 Leg Extension Length is Not Affected by Initial Position with Imageless Navigation System in Total Hip Arthroplasty Naoya Taki, Naoto Mitsugi, Yuichi Mochida, Masato Aratake, Hirohiko Ota, Hideo Kobayashi, Taichi Ideno, Tomoyuki Saito Poster No. 1068 Kinematic Evaluation of the MAKO Multi Compartmental Knee in a Knee Simulating Machine Peter S Walker, Gokce Yildirim, Michael Conditt, Sharon Branch, Ivan Madrid 108 Poster No. 1069 Cadaveric Analysis of an Accelerometer Based, Hand-held Navigation System for Distal Femoral Cutting Block Alignment in Total Knee Arthroplasty Denis Nam, Seth A Jerabek, Michael B Cross, David J Mayman Poster No. 1070 The Relationship between Morphology and Knee Kinematics in Total Knee Arthroplasty David A Wilson, Janie L Astephen Wilson, Richard Roda, Michael J Dunbar PS1 Implant Wear - Vitamin E Polyethylene Poster No. 1071 Three Year RSA Evaluation of the Wear of Vitamin E Stabilized Highly Cross-linked Polyethylene, the Stability of Regenerex™ Acetabular Shells and Femoral Components with 32mm Heads Meridith Greene, Charles R Bragdon, Young-Min Kwon, Harry Rubash, Henrik Malchau Poster No. 1072 Warm Irradiation of Vitamin E Stabilized UHMWPE Improves Strength and Oxidation Resistance Andrew Neils, Ebru Oral, Orhun K Muratoglu Poster No. 1073 Simultaneous improvement in the mechanical strength and oxidative resistance of Vitamin E blended UHMWPE Keita Uetsuki, Tomohiro Sugimoto, Alexander Turner, Soung-Hyu Hyon, Naohide Tomita Poster No. 1074 Controversial effects of blending Vitamin-E with UHMWPE on the wear resistance of Hip and Knee prostheses Keita Uetsuki, Tomohiro Sugimoto, Alexander Turner, Naohide Tomita Poster No. 1075 How does thermal treatment affect the wear characteristics of radiation-crosslinked UHMWPE with and without vitamin E? Lizeth Herrera, Kim-Phuong Le, Jason A Longaray, Lin Song, Twana Davisson, Shi-Shen Yau, Aiguo Wang PS1 Implant Wear - Metal on Metal & Ceramic Bearings Poster No. 1076 Metal ion results and clinico-radiological assessment of a conservative ceramic-on-metal hip device Joseph Daniel, Hena Ziaee, Chandra Pradhan, Derek J McMinn Poster No. 1077 Impact of Hard Phases within CoCrMo Cast Alloy on MoM Hip Wear Robin Pourzal, Shanshan Li, Richard J Underwood, Alister J Hart, Philippa M Cann, Alfons Fischer Poster No. 1078 Bearing-Foreign Material Deposition on Damaged Co-Cr Femoral Heads Nishant M Tikekar, Anneliese Heiner, Karen Kruger, Tom Baer, John Lannutti, Tom Brown Poster No. 1090A Artificial joint lubrication: Effect of Patient Synovial Fluid Properties on Implant Wear Philippa M Cann, Connor Myant, Ricgard Underwood Poster No. 1080 High Speed Wear Performance of Modern Hip Bearings Reginald Lee, Gaurav Khanna, Jason A Longaray, Henry Mena, Richard Walker PS1 Spine Poster No. 1081 Fluid-Film-Lubrication in Hard-on-Hard Bearings in Total Hip Arthroplasty J.Philippe Kretzer, Robert Sonntag, Johannes S Rieger, Sebastian Jaeger, Rudi G. Bitsch, Jan Nadorf, Joern Reinders Poster No. 1082 Friction in large diameter hip bearings in compromised lubrication conditions Nicholas E Bishop, Arne Hothan, Michael M Morlock Poster No. 1083 Wear Performance Comparison of 28mm MOM Explants to Largediameter MOM Ian Clarke, Jean Lazennec, Michelle Burgett, Dan Sufficool, Thomas Donaldson Poster No. 1084 Metal Ion Levels after Metal-on-Metal Hip Resurfacing are Correlated to Asymmetrical Loading during Functional Activity Stephen J Mellon, George Grammatopoulos, David W Murray, Harinderjit S Gill Poster No. 1091 Nationwide Trends in the Surgical Management of Lumbar Spinal Stenosis in all Age Groups Hyun W Bae, Sean S Rajaee, Linda E Kanim Poster No. 1092 Correlation Between Significant Cortical Signal Changes on Intraoperative Spinal Cord Monitoring and Blood Pressure During Lumbar Surgery Hrishikesh Gogineni, Ernie Young, Nicholas Ahn Poster No. 1093 Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Posterolateral Spinal Fusion: What’s the Right Dose? Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1094 Development of a Quantitative Method to Evaluate Lumbar Spinal Stenosis Nathaniel R Ordway, Yushek Pun, Kenneth Mann, William Lavelle Poster No. 1095 Wound Management by Local Hypothermia During Lumbar Spine Surgery John M Dawson, Gina J Konz, Terrance O Thomson, John K Hsiang Poster No. 1085 Serum Metal Ion Levels in Patients with a Large-diameter Metal-onmetal Total Hip Arthroplasty Masahiro Hasegawa, Takahiro Iino, Kakunoshin Yoshida, Shigeto Ikemura, Hiroki Wakabayashi, Akihiro Sudo Poster No. 1096 Long Term Corrosion Potential of Three Posterior Spinal Implant Materials Vaneet Singh, Jacob P Shorez, Kenny Sitton, Jeremy L Gilbert, Nadim Hallab Poster No. 1086 Wear and Wear Debris Generated from Ceramic-on-Carbon Fibre Reinforced PEEK Hip Replacements Christopher Brown, Claire L Brockett, Joanne L Tipper, Gemma John, Sophie Williams, John Fisher Poster No. 1097 Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) in Posterolateral Lumbar Spine Fusion: Complications in the Elderly Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1087 Tribological performance of 38mm ceramic-on-metal at various inclination angles Amir Kamali, Jasper Daniel, Joseph Pamu, Azad Hussain, Ruth Cameron Poster No. 1088 Wear Testing of Diffusion Hardened Oxidized Zirconium Hard-onHard Bearings after Inducing Liner Deformation Amit Parikh, Patrick Hill, Jeff Sprague, Vivek Pawar Poster No. 1089 Tribological performance of large diameter ceramic-on-metal mid head resection hip replacements Amir Kamali, Jasper Daniel, Joseph Pamu Poster No. 1090 Retrieval Analysis of Thirty Contemporary Ceramic-on-Ceramic Hip Replacements Trevor C Gascoyne, Thomas R Turgeon, Jan M Brandt Posters Poster No. 1079 Degraded Protein Deposits Identified on Ceramic and Metal-on-Metal Bearings Michelle Burgett, Ian Clarke, Thomas Donaldson Poster No. 1098 Adjuncts in Posterolateral Lumbar Spine Fusion: Comparison of Complications and Efficacy Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1099 Anatomical analysis of cervical posterior fusion (Roy-Camille lateral mass screw) with enhanced cervical CT scan Hirofumi Kosaka, Kosaku Higashino, Nori Satoh, Yuichiro Goda, Shinsuke Katoh, Natsuo Yasui Poster No. 1100 Difference in the Spinal Cord Posterior Shifting between C3-6 laminoplasty and C3-7 laminoplasty on Magnetic Resonance Imaging at 24 Hours after Cervical Laminoplasty Hitoshi Kudo, Kazunari Takeuchi, Hironori Otsuka, Yoshihito Yamasaki, Atsushi Ono, Toru Yokoyama, Satoshi Toh 109 Posters Poster No. 1101 Morphologic analysis of cervical spine using reconstructive computed tomography: a study of female cervical spondylotic myelopathy patients vs normal controls Shunichi Toki, Kosaku Higashino, Hirofumi Kosaka, Shinsuke Katoh, Natsuo Yasui Poster No. 1102 Analysis of Anterior Cervical Discectomy and Fusion Kinematics when Supplemented with Facet Screw Instrumentation Patrick D Leahy, Kirk McGilvray, Jonathan Sherman, Vincent Traynelis, Eric Nottmeier, Vaneet Singh, Brian Murrell, Vikas Patel, Christian Puttlitz Poster No. 1103 The Effect of Nitinol Staples on Spinal Growth Modulation Joe Carreau, Christine L Farnsworth, Diana A Glaser, Peter O Newton Poster No. 1104 Three Dimensional Visualization of the Intervertebral Disc: the Effects of Growth Modulation Diana A Glaser, Christine L Farnsworth, Joshua Doan, Peter O Newton Poster No. 1105 Does bipedality effect the morphology of the lumbar vertebrae and IVDs in mice? Nadir M Yalcin, O. Dede, I. Akel, G. Demirkiran, Emre Acaraglu, Ralph Marcucio Poster No. 1106 Pinealectomy impairs endochondral ossification and induces rapid cancellous bone loss Yoichi Aota, Hayato Terayama, Tomoyuki Saito, Masahiro Ito Poster No. 1107 How do Tamoxifene and Raloxifene effect bipedal scoliotic mice? Nadir M Yalcin, I. Akel, G. Demirkiran, O. Dede, D. Olgun, Ralph Marcucio, E. Acaroglu Poster No. 1108 Composition of Demineralized Bone Matrix-Based Products on Spinal Fusion Rate L. E Kanim, Justin Houman, Li Zhao, Yalda S Safai, Hyun Bae, Michael A Kropf,, Rick Delamarter Poster No. 1109 Spine Fusion by Non-viral Gene Transfer with BMP-2 in Null Mice Ruwei Lin, Gwo-Jaw Wang Poster No. 1110 Anti-Sclerostin (Scl-Ab) Increases Bone Mass and Fusion Volume in a Rat Posterolateral Spinal Fusion Model Andre D Shaffer, Owolabi A Shonuga, Joseph M Lane, Matthew Cunningham, Brandon P Hirsch, Hua Z Ke, Chaoyang Li Poster No. 1111 Bone Marrow Aspirate with a subeffective dose of rhBMP-2 in Spinal Fusion: A Quantitative Analysis Deborah C Marshall, Melodie F Metzger, Hyun W Bae, Li Zhao, Linda E Kanim, Pamela Wong, Rick B Delamarter 110 Poster No. 1112 Assessment of Silicate-Substituted Calcium Phosphate Bone Graft in a Rabbit Posterolateral Fusion Model with Concurrent Chemotherapy Douglas C Fredericks, Emily B Petersen, Ali Al-Hilli, James Nepola, Anup Gandhi, Swathi Kode, Nicole Grosland, Joseph Smucker Poster No. 1113 Dose-Dependent Enhancement of Spinal Fusion in Rats with Teriparatide [PTH (1-34)] Gang Li, Ming Ni, Jimmy Tin-Yan Cheng, Yunfeng Rui, Kai-Ming Chan, Stuart Kuhstoss, Yanfei L Ma, Masahiko Sato, Yan Wang Poster No. 1114 The Effect of Noggin Interference in a Rabbit Posterolateral Spinal Fusion Model Kaylene D Snow, Eric O Klineberg, Dominik R Haudenschild, Blaine A Christiansen, Tomasz Antkowiak, Chitrangada Acharya, Sukanta Maitra, Munish C Gupta Poster No. 1115 Elastin-derived Peptides Induce Human Ligamentum Flavum Cells Inflammation Through NF-Kappa-B Pathway YH Chao, YF Chiang, YH Tsuang, JS Sun, MH Chen, CK Cheng Poster No. 1116 Mineral composition and nanomechanical properties at the osteochondral interface within the developing vertebral endplate Rachel C Paietta, Evalina Burger, Virginia Ferguson Poster No. 1117 Retrieval Analysis of PEEK Rods for Posterior Lumbar Stabilization and Fusion Genymphas B Higgs, Daniel MacDonald, David Jaekel, Madhuri K Penmatsa, Christine M Ho, Todd H Lanman, Sigurd H Berven, Jorge E Isaza, Marla J Steinbeck, Steven M Kurtz Poster No. 1118 Histology of Periprosthetic Tissues and Analysis of Retrieved PEEK Spherical Nucleus Pulposus Replacements Christine M Ho, Madhuri K Penmatsa, Daniel MacDonald, Genymphas B Higgs, Jorge E Isaza, Steven M Kurtz, Marla J Steinbeck Poster No. 1119 Epidemiologic analysis of ossification of the posterior longitudinal ligament in cervical spine using reconstructive computed tomography Tetsuya Hirano, Kosaku Higashino, Shunichi Toki, Hirofumi Kosaka, Sinsuke Katoh, Natsuo Yasui Poster No. 1120 Characterization of Human Spinal Calcified Fibrocartilage Before and After Intervertebral Fusion Preparation Sarina K Sinclair, Jessica Grey, Michael Daubs, Darrel Brodke, Brandon Lawrence, Alpesh Patel Poster No. 1121 DensiProbe Spine: First Clinical Experience with Intraoperative Measurement of Bone Quality Lorin M Benneker, Albrecht Popp, Paul F Heini, Damiano Schiuma, Ronald Schwyn Poster No. 1123 Age-related Changes in Pedicle Morphology: Correlation with Lumbar Canal Diameter Yohei Ishihara, Alejandro A Espinoza Orías, Howard An, Gunnar B Andersson, Keizo Sugisaki, Peter Simon, Nozomu Inoue Poster No. 1124 Human Cervical Vertebral Endplate Morphometry: Variation by Gender and Age Rebecca A Wachs, Victoria M Michna, Eric H Ledet PS1 Spine Biomechanics Poster No. 1125 Comparisions of the In Vivo Flexibility Characteristics of Cervical Spine in Young Subjects with/without Chronic Neck Pain Chih-Hsiu Cheng, Jaw-Lin Wang, Carl P.C. Chen, Yu-Lin Chang Poster No. 1126 Single-Level Fusion Does Not Affect Cervical Spine Segmental Percentage Contributions to Head Rotation During Flexion-Extension William J Anderst, Michelle Schafman, William Donaldson, Joon Lee, James Kang Poster No. 1127 The Translation to Rotation Ratio of Cervical Vertebrae During Flexion-Extension William J Anderst, Nicolina DiNardi, William Donaldson, Joon Lee, James Kang Poster No. 1128 Cervical Spine Facet Joint Motion in Single-Level Anterior Fusion Patients and Age-Matched Asymptomatic Controls William J Anderst, Jon Foster, William Donaldson, Joon Lee, James D Kang Poster No. 1129 Cervical Disc Arthroplasty versus Disc Fusion: A Finite Element Study Anup Gandhi, Swathi Kode, Kiran Shivanna, Douglas Fredericks, Joseph Smucker, Nicole Grosland Poster No. 1130 Differentiating between Load and Displacement Controlled Wear Testing in an Artificial Cervical Disc - A Computational Comparison Sanghita Bhattacharya, Vijay K Goel, Alan S Greenwald Poster No. 1131 Neuromuscular Control of the Head and Neck Throughout Growth and Development Hitesh Mehta, Mandy Lai Chuck Choo, David Nuckley Poster No. 1132 A comparison of a Normal versus Unilateral Cervical Fixation Plate following a C5 Corpectomy Mageswaran Prasath, Elijah Hothem, Robb Colbrunn, Tara F Bonner, Adam Bartsch, Robert F Mclain Poster No. 1133 Biomechanical Evaluation of Unilateral and Bilateral C1 Lateral Mass - C2 Intralaminar Screw and Rod Fixation Nitin Bhatia, Asheen Rama, Brandon Sievers, Ryan Quigley, Thay Q Lee Poster No. 1134 Bailout Screw Placement Option for the Subaxial Cervical Spine (C3 to C6): A Biomechanical Study of Posterior Cervical Spinolaminar Screw Placement Ferris M Pfeiffer, Craig Kuhns, Tyler Jenkins, Joel Jeffries, Theodore J Choma Posters Poster No. 1122 Effects of Age and Spinal Level on the Dimensions of the Lumbar Spinal Canal Measured in vivo J. S An, A. A Espinoza Orías, Howard An, Gunnar B Andersson, Nozomu Inoue Poster No. 1135 Measurement of Cervical Intervertebral Disc Bulge Farid Amirouche, Krzystov Siemionow, Steven Mardjetko, Giovanni Solitro, David Drucker, Michael Hutchinson Poster No. 1136 The Influence of the Intervertebral Discs on Vertebral Mechanics and Fracture Patterns Amira Hussein, Zachary Mason, Elise Morgan Poster No. 1137 Evaluation of the Ability of µCT-based Structural Rigidity and ImageBased Strain Measurement in Predicting Yield Loads in Healthy and Metastatically Involved Rat Vertebrae Seyed-Parsa Hojjat, Lisa Wise-Milestone, Margarete K Akens, Cari Whyne Poster No. 1138 Predicting Rate-dependent Lumbar Spine Biomechanics: Range of Motion, Neutral Zone, Stiffness, and Hysteresis Dean K Stolworthy, Shannon A Zirbel, Larry L Howell, Anton E Bowden Poster No. 1139 Effects of Age and Level on the Lumbar Facet Joint Position Yohei Ishihara, Alejandro A Espinoza Orías, Howard An, Gunnar B Andersson, Nozomu Inoue Poster No. 1140 Non-intuitive Changes in Spine Biomechanical Response with Testing Temperature and Compressive Load Dean K Stolworthy, Shannon A Zirbel, Anton E Bowden, Larry L Howell Poster No. 1141 Is Microstructural Heterogeneity Accounted for by Plate/Rod-Likeness of Trabeculae in Vertebral Cancellous Bone? Yener Yeni, Daniel Oravec Poster No. 1142 The role of endplates in strain distributions and microstructural organization within the vertebral shell and cancellous centrum of a rat T5 vertebra during loading Daniel Oravec, Roger Zauel, Yener Yeni Poster No. 1143 Regional Strain Variation in the Human Cadaveric Lumbar Facet Capsular Ligament Amy A Claeson, Victor H Barocas, David Nuckley 111 Posters Poster No. 1144 Effect of intra-abdominal pressure on lumbar spinal joint forces, muscle forces and centers of vertebral rotation Won Man Park, Shaobai Wang, Kirkham B Wood, Yoon Hyuk Kim, Guoan Li Poster No. 1145 Computationally Efficient Rigid/Deformable Finite Element Model of the Lumbar Spine Sean Smith, Milind Rao, Dana Coombs, Randy Ching, Mike Bushelow, Peter J Laz, Paul Rullkoetter Poster No. 1146 Regression Equations for Spinal Loads in Asymmetric Lifting Tasks Using a Finite Element Biomechanical Model A. Shirazi-Adl, N. Arjmand, A. Plamondon, C. Larivière, M. Parnianpour Poster No. 1147 Vertebral Micromechanics for Forward Flexion Loading Haisheng Yang, Shashank Nawathe, Aaron J Fields, Tony M Keaveny Poster No. 1156 Quantitative Comparison of UHMWPE Wear Particles Generated from ProDisc-L and Charité Total Disc Replacements Tested Under ISO and ISO plus AP Shear Inputs Joanne L Tipper, Rachel Vicars, Philip Hyde, Thomas Brown, Eileen Ingham, John Fisher, Richard M Hall Poster No. 1157 The Influence of ProDisc-L Positioning on Mechanics of the Lumbar Spine Milind Rao, Christopher Cain, Paul Rullkoetter Poster No. 1148 In-vivo loads on the lumbar intervertebral discs during weight lifting Shaobai Wang, Won Man Park, Jun Miao, Yoon Hyuk Kim, Kirkham B Wood, Guoan Li Poster No. 1158 Parametric and Cadaveric Models of Lumbar Flexion Instability and Flexion Restricting Implant Louie Fielding, Todd F Alamin, Leonard Voronov, Gerard Carandang, Robert M Havey, Manish Kothari, Avinash G Patwardhan Poster No. 1149 The Impact of Low Back Pain or Degeneration on the Coupled Outof-Plane Rotations in the Lumbar Spine Christopher B Carr, Joseph Cheng, Adrija Sharma, Richard D Komistek, Mohamed Mahfouz Poster No. 1159 Short Segment Fixation of an L1 Compression Fracture - 4 vs. 6 Screws Robert Norton, Edward Milne, David Kaimrajh, Seth Williams, Frank Eismont, Loren Latta Poster No. 1150 Motion Characteristics of the Vertebral Segments with Lumbar Degenerative Spondylolisthesis Jun Miao, Shaobai Wang, Won Man Park, Qun Xia, Kirkham B Wood, Guoan Li Poster No. 1160 Motion Compensation and Correspondent Intradiscal Pressure of Flexible Spinal Screw-Rod Fixation Implant Chun-Ming Tu, Wen-Kai Chou, Chun Hsien Liu, Been Der Yang, ShanChang Chueh, Yu-Shi Weng, Jaw-Lin Wang Poster No. 1151 Biomechanics of an Allograft Threaded Facet Dowel: Evaluation by a Multi-Axis and Multi-Parameter Test Strategy C.K. Demetropoulos, A. Kiapour, B.J. Evanson, H. Elgafy, V.K. Goel, D.J. Svach, D. Chow, B.Z. Roitberg Poster No. 1161 Biomechanical Analysis of Rods of Lumbar Spinal Implant on Intradiscal Pressure Wen-Kai Chou, Ying-Sian Chen, Wan-Ju Lin, Been Der Yang, ShanChang Chueh, Yu-Shi Weng, Jaw-Lin Wang Poster No. 1152 Experimental Evaluations of Intervertebral Disc Mechanics Following Posterolateral Fusion are Dependent on Testing Protocol Ben Gadomski, Christian Puttlitz Poster No. 1153 Prophylactic Implantation of Interspinous Spacer in Rigid Lumbar Fusion Surgery Prevent Hyper Extension, but Has Less Affect on Intradiscal Pressure Hsi Ching Hsu, Wen-Kai Chou, Been Der Yang, Shan-Chang Chueh, YuShi Weng, Jaw-Lin Wang Poster No. 1154 Biomechanical Evaluation of Interbody Fusion Construct Stability: Contribution of Lateral-Approach Cage Footprint Size and Comparison with TLIF Constructs Luiz Pimenta, Alexander W Turner, Zachary Dooley, Rachit Parikh, Mark Peterson 112 Poster No. 1155 Dynamic Biomechanical Examination of the Lumbar Spine with Implanted Total Spinal Segment Replacement (TSSR) Utilizing a Pendulum System Alan H Daniels, Sarath Koruprolu, David Paller, Matthew McDonnell, Joseph Crisco Poster No. 1162 The Role of Soft Tissue Restraints Following Type II Odontoid Fractures in the Elderly - A Biomechanical Study C. Maxwell J McCabe, Stewart D McLachlin, Kevin R Gurr, Stewart I Bailey, Chris S Bailey, Cynthia E Dunning Poster No. 1163 The Structural Response of Human spines with Osteolytic Defect under complex loading: FEA study Ron N Alkalay Poster No. 1164 Validation of a Non-invasive Automated Hierarchical Method to Precisely Measure Lumbar Spine Movement Abedul Haque, William J Anderst, Scott Tashman, Elisabeta Marai Poster No. 1165 Response of the Intervertebral Disc and Subchondral Bone to In-Vivo Dynamic and Static Loading Sarah Linley, Glenn Sanders, Elizabeth Leimer, Jeffrey Lotz, Gwendolyn Sowa, Jackie Vanderzanden, Joseph Glennon, Darryl DiRisio, James Lawrence, Eric Ledet Poster No. 1166 Influence of Disc Degeneration on Endplate Concavity Alejandro A Espinoza Orías, Howard An, Gunnar B Andersson, Nozomu Inoue Poster No. 1167 The Effect of Repeated Impacts on Intervertebral Disc Mechanics During a Diurnal Cycle David Jamison, Eric C Pierce, Michele Marcolongo Poster No. 1168 The Stress and Strain State of the Annulus under Damaging Loading Conditions Diane R Wagner, Nathaniel T Hollingsworth Poster No. 1169 The Effect of Dynamic Loading on Intervertebral Disc Matrix Integrity and Cell Viability Lisbet Haglund, Janet Moir, Lorne Beckman, Kyle Mulligan, Bernice Jim, Jean Ouellet, Peter Roughley, Thomas Steffen Poster No. 1170 Comparison of Intervertebral Disc Water Content And Dynamic Properties Degradation Due to Trypsin and Glycation Induced Degeneration - An Ex Vivo Porcine Disc Model I-Ting Chuang, Yu-Chun Hsu, Ya-Ching Chang, Jian-Hong Lin, Ya-Wen Kuo, Mohammad Nikkhoo, Jaw-Lin Wang Poster No. 1171 Changes in the Matrix Composition of the Degenerating Human Intervertebral Disc and their Relative Influence Towards Annulus Fibrosus and Nucleus Pulposus Tissue Mechanical Behavior Lee-Jae Morse, Alok Sharan, Louis Chen, Simon Tang Poster No. 1172 Micromechanics of Annulus Fibrosus: Role of Macromolecules Jessica L Isaacs, Edward Vresilovic, Michele Marcolongo Poster No. 1173 Collagen Fibers Contribute to the Compressive Stiffness of the Intervertebral Disc Corrinus C van Donkelaar, Anne M Römgens, Keita Ito Poster No. 1174 Static and Dynamic Compressive Characterization of Lumbar Intervertebral Discs of the Adult New Zealand White Rabbit Alex P Taborek, Albert Chen, Tomonori Yamaguchi, Quynhhoa T Nguyen, Nozomu Inoue, Koichi Masuda, Robert L Sah Poster No. 1175 Biphasic Material Properties of Biochemical and Biomechanical Degenerated Intervertebral Disc - An Ex Vivo Porcine Disc Creep Test with Optimization of Finite Element Simulation Mohammad Nikkhoo, Yu-Chun Hsu, Ya-Ching Chang, Mohammad Haghpanahi, Mohamad Parnianpour, Jaw-Lin Wang Posters PS1 Spine - Intervertebral Disc Biomechanics PS1 Spine - Intervertebral Disc Biology Poster No. 1176 WITHDRAWN Poster No. 1177 Nutrient Metabolic Rates of Normal Human Intervertebral Disc Cells Sarah Cisewski, Yongren Wu, John Baatz, Barton Sachs, John Glaser, Hai Yao Poster No. 1178 WITHDRAWN Poster No. 1179 Direct chronic exposure to tobacco smoke induced spinal degeneration Nam Vo, Dong Wang, Luigi A Nasto, Qing Dong, Gwendolyn A Sowa, Arvydas Usas, Joon Lee, Adriana Leme, Steven Shapiro, Peter Roughley, James D Kang Poster No. 1180 Glutathione Protects human nucleus pulposus cells from hydrogen peroxide-induced cell death and impaired extracellular matrix metabolism Xinlin Yang, Daidong Wang, Dazhi Yang, Francis Shen, Xudong Li Poster No. 1181 Substance P Stimulates Production of Inflammatory Cytokines in Human Disc Cells Christopher Kepler, Dessislava Z Markova, Alan S Hilibrand, Ravi K Ponnappan, James Dowdell, Alexander R Vaccaro, Todd J Albert, Makarand Risbud, D. G Anderson Poster No. 1182 Fibronectin Fragments in Human Intervertebral Disc Tissue and their Effects on Disc Cells Yejia Zhang, Dessislava Z Markova, Nancy Ruel, Sherrill L Adams, Howard An, Eugene Thonar, Mark Zack, Carla R Scanzello, David G Anderson Poster No. 1183 Regulation of CCN2 by Hypoxia in the Nucleus Pulposus Cells of the Intervertebral Disc Cassie M Tran, Irving Shapiro, Makarand Risbud Poster No. 1184 Investigating the Roles of Neurotrophins on Nucleus Pulposus (NP) Cells and NP Cell-Neural Cell Interactions Stephen M Richardson, Devina Purmessur, Ben Probyn, Judith Hoyland Poster No. 1185 Fas-Ligand Plays an Important Role in the Production of Proinflammatory Cytokines in the Human Nucleus Pulposus Cells Junya Yamamoto, Koichiro Maeno, Toru Takada, Kenichiro Kakutani, Takashi Yurube, Zhongying Zhang, Hiroaki Hirata, Takuto Kurakawa, Daisuke Sakai, Joji Mochida, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida 113 Posters Poster No. 1186 HIF-1α and HIF-2α Degradation Is Differentially Regulated in Nucleus Pulposus Cells of the Intervertebral Disc Nobuyuki Fujita, Kazuhiro Chiba, Irving Shapiro, Makarand Risbud Poster No. 1187 Pathophyological Role of PKC delta-Runx2 axis in Spondylosis: in vitro and in vivo studies Michael Ellman, Jae-sung Kim, Xin Li, Jeffrey S Kroin, Qiping Zheng, Gabriella Cs-Szabo, Howard An, Di Chen, Ming Ding, Jitesh Pratap, Andre J. van Wijnen, Hee-Jeong Im Poster No. 1188 Optimization of the Enzyme-induced Disc Degeneration Model for the in-vitro study of Nucleus Pulposus Tissue Engineering Benjamin Gantenbein, Lorin M Benneker, Klaus Siebenrock, Samantha C Chan Poster No. 1189 Rat Tail Static Compression Model with Loading Removal Mimics Differential Early to Late Stages of Intervertebral Disc Degeneration Hiroaki Hirata, Takashi Yurube, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Zhongying Zhang, Junya Yamamoto, Takuto Kurakawa, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Poster No. 1190 Rat Tail Static Compression Model Mimics Extracellular Matrix Metabolism Related to Apoptosis Relative to Autophagy in Interverbral Disc Degeneration Takashi Yurube, Hiroaki Hirata, Kenichiro Kakutani, Koichiro Maeno, Toru Takada, Zhongying Zhang, Junya Yamamoto, Takuto Kurakawa, Hiroshi Sasaki, Koji Takayama, Takehiko Matsushita, Ryosuke Kuroda, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Poster No. 1191 A Pain Related Behavior and Intervertebral Disc Degeneration After Lumbar Facetectomy in the Rat - A New Animal Model for Degenerative Disc Disease Daisuke Fukui, Mamoru Kawakami, Shin-ichi Nakao Poster No. 1192 Intervertebral disc whole organ culture model to investigate the effect of TGFβ3 after discectomy Svenja Illien-Junger, Jillian E Mayer, Benjamin C Walter, Qureshi Sheeraz, Andrew hECHT, James Iatridis Poster No. 1193 Comparison of the Response of Nucleus Pulposus Cells and Articular Chondrocytes to Treatment with Hyaluronan Oligosaccharides Joseph A Chiaro, George R Dodge, Nader M Hebela, Robert L Mauck, Dawn M Elliott, Lachlan J Smith Poster No. 1194 A Whole Organ Culture Model for Intervertebral Disc Using Rat Tail Explants in a Rotating Bioreactor Kazuya Edamura, James T Stannard, Aaron M Stoker, Grace O’Connell, Keiichi Kuroki, Clark T Hung, Theodore Choma, Joel Jeffries, James L Cook 114 Poster No. 1195 Variations in the Phenotypic Profile of Adult Degenerate NP Cells According to Spinal Region Francesca E Ludwinski, Kanna Gnanalingham, Stephen M Richardson, Anthony J Freemont, Judith Hoyland Poster No. 1196 Notochordal Cell Marker Expression in The Adult Human Nucleus Pulposus Francesca E Ludwinski, Kanna Gnanalingham, Stephen M Richardson, Anthony J Freemont, Judith Hoyland Poster No. 1197 Phenotypic Uniqueness of Notochordal Cells and Similarities to Chondrocytes Victor Leung, Foonlian Lim, Danny Chan, Rocky Tuan, Kenneth Cheung Poster No. 1198 Cell models for the human intervertebral disc: nucleus pulposus and annulus fibrosis Guus Van den Akker, Tim Welting, Don Surtel, Andy Cremers, Willem Voncken, Lodewijk Van Rhijn PS1 Spinal Therapeutics Poster No. 1199 Sustained Delivery of IL-1ra from PLGA Microspheres Attenuates IL-1β Mediated Degradation of Engineered Nucleus Pulposus Deborah J Gorth, Joseph A Chiaro, George R Dodge, Nader M Hebela, Robert L Mauck, Dawn M Elliott, Lachlan J Smith Poster No. 1200 In Vivo Bilateral Compressive Stresses in Disc Annulus: Effect of Hemiepiphyseal Implant in Quadruped Donita Bylski-Austrow, David L Glos, Frank E Sauser, Eric J Wall, Viral Jain, Alvin Crawford Poster No. 1201 A Novel Therapeutic for Rescuing the Adverse Effects of Advanced Glycation End-products in the Intervertebral Disc Simon Tang, Lee-Jae Morse, Louis Chen, Alok Sharan Poster No. 1202 Differential Responses of Human Nucleus Pulposus Cells with Varying Degenerative Levels to TGFβ3, CTGF, and Link-N Rosalyn D Abbott, Devina Purmessur, David R Brigstock, James Iatridis Poster No. 1203 Notochordal-rich tissue inhibits neurite extension and maintains neural cell viability Devina Purmessur, Javier Guzman, Samuel K Cho, James Iatridis Poster No. 1204 Allogeneic Articular Chondrocyte Survived in the Degenerating Rabbit Intervertebral Disc In Vivo: Implications for Cell Therapy with Allogeneic Cells Yejia Zhang, Ana Chee, Peng Shi, Er-Yun Chen, Isaac Moss, Tong-Chuan He, Eugene Thonar, Howard An Poster No. 1206 Particle Diffusion of Denatured and Crosslinked Anulus Fibrosus and Nucleus Pulposus Jian-Hong Lin, Te-Chun Liu, Yu-Chun Hsu, I-Ting Chuang, Ya-Wen Kuo, Jaw-Lin Wang Poster No. 1207 Influence of Oxygen Saturation on Phenotypic Behavior of Human Nucleus Pulposus Cells Shu-Hua Yang, Ming-Hsiao Hu, Feng-Huei Lin PS1 Upper Extremity - Shoulder & Elbow Poster No. 1208 Bone Wafer Thickness in Lesser Tuberosity Osteotomy Repairs during Total Shoulder Arthroplasty Mark Carl Miller, Claudius Jarrett, David M Weir, Brandon Brown, Carmen Latona, Christopher C Schmidt Poster No. 1209 Novel Damage Scoring Method for Evaluation of CoCr Humeral Head Surfaces Farzana Ansari, Eli Patten, Cynthia Cruz, Jihye Lee, Steve Gunther, Tom Norris, Michael Ries, Lisa Pruitt Poster No. 1210 Classification of Scratches on Retrieved Cobalt Chrome Humeral Heads Using 3D Profilometry Eli W Patten, Erin Beitel, Amelia Swan, Farzana Ansari, Cynthia Cruz, Steve Gunther, Tom Norris, Michael Ries, Lisa Pruitt Poster No. 1211 A Correlation of Five Commonly Used Clinical Metrics to Measure Outcomes in Shoulder Arthroplasty Christopher P Roche, Pierre Flurin, Thomas Wright, Joseph Zuckerman, Diane Johnson, Matt Christensen Poster No. 1212 Glenohumeral Kinematics for Healthy, Osteoarthritic, and Post Total Shoulder Arthroplasty Shoulders Bradley A Meccia, Edwin Spencer, Sumesh M Zingde, Filip Leszko, Mohamed Mahfouz, Richard D Komistek Poster No. 1213 Optimizing Surgical Outcomes in Shoulder Arthroplasty: Importance of Accurate Implantation and Pre-Operative planning Andreas Kontaxis, Garth R Johnson, Angus W Wallace Poster No. 1214 Effect of Incomplete Reaming on Glenoid Loosening in Total Shoulder Arthroplasty: A Finite Element Analysis Charlie Yongpravat, Thomas R Gardner, Louis U Bigliani, William N Levine, Christopher S Ahmad Poster No. 1215 Fixation Micromechanics of Cemented Glenoid Replacements Gregory S Lewis, Jacob B Brenza, Emmanuel M Paul, April D Armstrong Poster No. 1216 Validation of a Reverse Shoulder Impingement Model: Influence of Glenoid Plate Positioning on Scapular Notching Christopher P Roche, Brian Martin, Thomas Wright, Pierre Flurin, Sean Grey, Richard Jones, Howard Routman, Greg Gilot, Joseph Zuckerman Poster No. 1217 Scapular Notching Radiographic Analysis: Recommendations for Glenoid Plate Positioning and Glenosphere Overhang in Male and Female Patients Christopher P Roche, Thomas Wright, Pierre Flurin, Sean Grey, Richard Jones, Howard Routman, Greg Gilot, Joseph Zuckerman Posters Poster No. 1205 Exogenous Crosslinker Assists Disc Structural and Functional Recovery from Biochemical and Mechanical Induced Degeneration An ex vivo Study Using Whole Disc Culture System Yu-Chun Hsu, Ya-Ching Chang, Jian-Hong Lin, I-Ting Chuang, Ya-Wen Kuo, Mohammad Nikkhoo, Jaw-Lin Wang Poster No. 1218 Deltoid Force and Excursion Demands of the Reverse Total Shoulder Prosthesis Compared to Massive Rotator Cuff Tear Brian R Onstot, Nathan D Richardson, Ryan A Neeley, Marc C Jacofsky, James C Otis, Matthew L Hansen Poster No. 1219 Technique to Quantify the Morphology of the Lateral Border of the Scapula and Scapular Notching Heath Henninger, Michael Harris, Kristen Petersen, Robert Burks, Robert Tashjian, Andrew E Anderson Poster No. 1220 Eccentric Joint Contact Loading Occurs after Total Shoulder Arthroplasty Radhika J Patel, Daniel Choi, Timothy Wright, Yingxin Gao Poster No. 1221 Effects of Humeral Head Shape in Shoulder Hemiarthroplasty: A Comparison of Semi-elliptical and Spherical Heads in Cadavers Bong Jae Jun, Joseph P Iannotti, Michelle McGarry, Jae Chul Yoo, Ryan Quigley, Thay Q Lee Poster No. 1222 Stress Distribution Pattern of Glenoid in Asymptomatic Baseball Players Assessed by Computed Tomography Osteoabsorptiometry by Computed Tomography Osteoabsorptiometry Tomohiro Shimizu, Tadanao Funakoshi, Norimasa Iwasaki, Makoto Motomiya, Kinya Nishida, Naomi Oizumi, Akio Minami Poster No. 1223 Comparison of Rotator Cuff Muscle Architecture between Humans and Selected Vertebrate Species Margie Mathewson, Alan Kwan, Carolyn Eng, Richard Lieber, Samuel Ward Poster No. 1224 Effect of Return to Overuse Activity Following an Isolated Supraspinatus Tendon Tear On Adjacent Intact Tendons and Glenoid Cartilage in a Rat Model Katherine E Reuther, Joseph J Sarver, Stephen J Thomas, Chang S Lee, Chancellor F Gray, Jennica J Tucker, David L Glaser, Louis J Soslowsky Poster No. 1225 High Cholesterol Increases Supraspinatus Tendon Mechanical Properties Across Multiple Species David P Beason, Jason E Hsu, Lena Edelstein, Chang S Lee, Brian C Lee, Stephanie M Marshall, Allison L McDaniel, Ryan E Temel, Joseph A Abboud, Louis J Soslowsky 115 Posters Poster No. 1226 Subscapularis Partial Tear Pattern Characteristics, Strain Pattern, and Implications for Repair Jae Chul Yoo, Nickul S Jain, Sang Jin Shin, Bong Jae Jun, Michelle McGarry, Christopher N Bui, Thay Q Lee Poster No. 1227 Skeletal Muscle Passive Mechanical Properties Change after Rotator Cuff Injury in a Rat Model Ki S Lee, Anthony J Choi, Evie Lin, Chanteak Lim, Megan L Killian, Leesa M Galatz, Stavros Thomopoulos, Sam Ward Poster No. 1228 Additional Half Hitch is Necessary for Knot Tying in Arthroscopic Shoulder Surgery: A mechanical testing Study Yasuo Itami, Teruhisa Mihata, Chisato Watanabe, Mitsuo Kinoshita Poster No. 1229 The Influence of Suturing Techniques on Rotator Cuff Repairs: A Finite Element Study Dane Dabirrahmani, Michael C Hogg, Richard C Appleyard, Mark Haber, Ronald M Gillies Poster No. 1230 Effect of Pretension and Suture Needle Type on Mechanical Properties of Acellular Human Dermis Patches for Rotator Cuff Repair Sambit Sahoo, Clay B Greeson, Jesse A McCarron, Ryan A Milks, Amit Aurora, Esteban Walker, Joseph P Iannotti, Kathleen A Derwin Poster No. 1231 The influence of bio-implant augmentation of massive rotator cuff repair; a biomechanical analysis Olivier A Van der Meijden, Coen A Wijdicks, Kyle S Jansson, Trevor R Gaskill, Peter J Millett Poster No. 1232 Stress Distribution within the Rotator Cuff Tendon with a Crescentshaped and an L-shaped Tears Hirotaka Sano, Atsushi Takahashi, Daisuke Chiba, Taku Hatta, Kei Imagawa, Koshi N Kishimoto, Nobuyuki Yamamoto, Eiji Itoi Poster No. 1233 Propagation of a Traumatic Rotator Cuff Tear During Increasing Levels of Cyclic Loading Brian DeWillie, Yuichi Hoshino, Paulo Araujo, Satoshi Terada, Yoshimasa Fujimaki, Volker Musahl, Richard E Debski Poster No. 1234 Ultrasound changes after rotator cuff repair - is supraspinatus tendon thickness related to pain? Liz Tham, Lisa Briggs, George A Murrell Poster No. 1235 Does subacromial injection of a local anesthetic influence strength in healthy shoulders? - A double blinded, placebo-controlled study Mazda Farshad, Michele Ecker, Reto Sutter, Martin Schubert, Christian Gerber Poster No. 1236 Inflammatory Cytokines Are Overexpressed in Subacromial Bursa of the Frozen Shoulder Chul-Hyun Cho, Eun-young Ha, Kyung-Jae Lee 116 Poster No. 1237 Platelet Rich Plasma Stimulation in Human Subacromial Bursal Cells Byung J Lee, Benjamin G Bruce, Mindy A Cote, Theodore A Blaine Poster No. 1238 CXCR4 Inhibitor (AMD 3100) Does Not Impede Rotator Cuff Tendon Healing in an Animal Model Daniel L Aaron, Benjamin G Bruce, Mindy A Cote, David J Paller, Lee Kaback, Douglas Scott, Francis Y Lee, Louis Bigliani, Theodore A Blaine Poster No. 1239 Biomechanical and Histological Analysis after Tenotomy of the Long Head of the Biceps in the Rabbit Shoulder Model Sae Hoon Kim, Joo Han Oh, Goo Hyun Baek, Seung Han Shin, Ji Wook Choi Poster No. 1240 Restoration of Anterior-Posterior Rotator Cuff Force Balance Alters Glenoid Properties in a Chronic Cuff Tear Rat Model Chancellor F Gray, Katherine E Reuther, Jason E Hsu, Chang Soo Lee, Joseph J Sarver, Susan M Schultz, Chandra M Sehgal, David L Glaser, Louis J Soslowsky Poster No. 1241 The Effect Of Rotator Cuff Integrity On Dynamic, In-Vivo Glenohumeral Joint Motion Michael J Bey, Jeffrey Haladik, Michael J McDonald, Nicole L Ramo, Patricia A Kolowich, Terrence R Lock, Vasilios Moutzouros Poster No. 1242 Biomechanical Factors Predisposing to Propagation of Fullthickness Rotator Cuff Tears: Tear Size, Shoulder Elevation and Rotation, and Rotator Cuff Muscle Strength Teruhisha Mihata, Bong Jae Jun, Ryan Quigley, Michelle McGarry, Mitsuo Kinoshita, Thay Q Lee Poster No. 1243 Evaluation of subscapularis tendon tear on preoperative MRI Kazuhito Sugimori, Ryuichi Gejo, Hayato Mine, Tomoatsu Kimura Poster No. 1244 Radiocapitellar Correlation: Implications for Hemiarthroplasty Dave R Shukla, Matthias Vanhees, Kai-Nan An, Shawn W O’Driscoll Poster No. 1245 Effect of Stem Length on Prosthetic Radial Head Micromotion Dave R Shukla, James S Fitzsimmons, Kai-Nan An, Shawn W O’Driscoll Poster No. 1246 Quantitative UHMWPE Wear Maps from Retrieved Total Elbow Arthroplasty Judd S Day, Daniel MacDonald, Matthew Ramsey, Bernard Morrey, Patrick M Connor, Steven M Kurtz Poster No. 1247 Development of a Laboratory Wear Test Methodology for the Evaluation of Total Elbow Prostheses Brian Kincaid, Kimberly Mimnaugh, Judd W Day, Matthew L Ramsey, Bernard F Morrey Poster No. 1259 A Gender Study of Computer Generated Cartilage at the Thumb Carpometacarpal (CMC) Joint Eni Halilaj, Michael J Rainbow, Christopher Got, Douglas C Moore, Joseph Crisco Poster No. 1249 Comparing Two Constitutive Material Models of Cartilage for Hemiarthroplasty Articular Contact Mechanics using Computational Analyses Ryan Willing, Emily A Lalone, Graham King, James J Johnson Poster No. 1260 Coupling of Thumb CMC Joint Motion During the Initiation of Jar Grasp, Key Pinch, and Jar Twist Tasks Eni Halilaj, Michael J Rainbow, Joel B Schwartz, Christopher Got, ArnoldPeter C Weiss, Amy Ladd, Douglas C Moore, Joseph Crisco Poster No. 1250 Application of a Strain-Adaptive Model to Assess the Influence of Stem Material on Bone Density Distribution in the Distal Ulna Mark A Neuert, Cynthia E Dunning Poster No. 1261 In Vivo Joint Contact Patterns within the Thumb Carpometacarpal Joint using Dynamic CT Imaging A. Goto, Shuai Leng, K. Sugamoto, S. Kakar, C. McCollough, K. An, K. Zhao Poster No. 1251 Axial Length and Overstuffing Affects Radiocapitellar Pressures, a Cadaveric Study Prasad J Sawardeker, Check C Kam, Winston Elliott, Edward Milne, Loren Latta, Ouellette A Elizabeth Poster No. 1262 Contributions of Cartilage and Ligaments to the Scaphoid Flexion Moment during the Dart Thrower’s Motion Michael J Rainbow, Eni Halilaj, Joel B Schwartz, Robin Kamal, Joseph Crisco PS1 Upper Extremity - Hand & Wrist Poster No. 1263 Peripheral TFCC tears Cause Ulnocarpal Instability: a Biomechanical Study Christopher J Dy, Anna-Lena Makowski, Edward Milne, Loren Latta, Elizabeth A Ouellette Poster No. 1252 Triqutral Rotational Index: A Measure of Ulnocarpal Instability Christopher J Dy, Arianna Trionfo, Anna-Lena Makowski, Edward L Milne, Loren Latta, Elizabeth A Ouellette PS1 Muscle/Nerve Poster No. 1253 Wrist and Forearm Motions to Reach Targets Cannot be Modeled by Simple, Uncoupled Motions Bethany Wilcox, Michael J Rainbow, Albert C Lo, Elizabeth Drewniak, Susan E D’Andrea, Scott Wolfe, Joseph Crisco Poster No. 1264 Matrix Metalloproteinase 3 knock-out mice Resist Degradation of the Neuromuscular Junction following Nerve Transection Injury Tom Chao, Derek Frump, Nima Nassiri, James Jung, Tahseen Mozaffar, Ranjan Gupta Poster No. 1254 Comparing Finite Element and Contact Modeling Techniques to Evaluate Radiocarpal Joint Mechanics Joshua E Johnson, Phil Lee, Terence E McIff, E Bruce Toby, Kenneth J Fischer Poster No. 1265 Neuroprotective effect of the anti Tumor necrosis factor-α therapy in an experimental model of the rat sciatic nerve injury Katsuyuki Iwatsuki, Michiro Yamamoto, Toshikazu Kurahashi, Tetsuro Ohnishi, Hitoshi Hirata Poster No. 1255 Evaluation of an Examination Maneuver for Ulnocarpal Instability: a Biomechanical Study Christopher J Dy, Anna-Lena Makowski, Edward Milne, David Kaimrajh, Loren Latta, Elizabeth A Ouellette Poster No. 1266 Effects of multiple nerve crushes on functional recovery of the sciatic nerve Toshiro Itsubo, Nanae Fukushima, Koichi Nakamura, Masanori Hayashi, Shigeharu Uchiyama, Tetsuji Moriizumi, Hiroyuki Kato Poster No. 1256 Movement of the Distal Carpal Row During Narrowing and Widening of Carpal Arch Width Joseph N Gabra, Mathieu F Domalain, Zong-Ming Li Poster No. 1267 Evaluation of sciatic nerve function after ultrasonic and electrocautery dissection -An electromyographic study Katsumasa Tanimoto, Basma Khoury, Ke Feng, John M Cavanaugh Poster No. 1257 Wrist Tendon Forces are Least in Forearm Supination Leela D Farr, Frederick W Werner, Michael L McGrattan, Sierra R Zwerling, Brian J Harley Poster No. 1268 Acute and Sub-acute Effects of Electrosurgery and Harmonic Devices on Sciatic Nerve Function and Structure Chaoyang Chen, Anuja Vedpathak, Srinivasu Kallakuri, Katsumasa Tanimoto, Prasanna Malaviya, John M Cavanaugh Poster No. 1258 WITHDRAWN Posters Poster No. 1248 The Effect of Implant Design of Linked Total Elbow Replacements on Stability and Stress: A Finite Element Analysis Ryan Willing, James J Johnson, Graham King 117 Posters Poster No. 1269 Motoneuron Integrated Striated Muscle Restores Motor Function in Denervated Rats Shigeru Kurimoto, Masahiro Tatebe, Michiro Yamamoto, Nobuyuki Okui, Natsume Tadahiro, Tetsuya Arai, Katsuyuki Iwatsuki, Shuichi Kato, Hideyuki Ota, Hitoshi Hirata Poster No. 1279 Transcutaneous Carbon Dioxide Application after Endurance Exercise in Rat Keisuke Oe, Masahiko Miwa, Yoshitada Sakai, Takahiro Niikura, Sang Yang Lee, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Takeshi Ueha, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 1270 Percutaneous Electrical Stimulation to Motoneuron Integrated Striated Muscles (MISM) Shuichi Kato, Hitoshi Hirata, Masahiro Tatebe, Michiro Yamamoto, Nobuyuki Okui, Shigeru Kurimoto, Tetsuya Arai, Tadahiro Natsume, Katsuyuki Iwatsuki Poster No. 1280 Histopathology highlights spatial heterogeneity in injured muscle in a compartment syndrome athymic rat model Burhan Gharaibeh, Nick Oyster, Aaron Boyer, Minakshi Poddar, Michelle Witt, Johnny Huard Poster No. 1271 Do Ruffini Mechanoreceptors Have a Preferred Sensing Direction? Gwen E Palmer, Mark Taylor, Tiina Roose Poster No. 1281 The Effect of Ischaemic Preconditioning in Total Knee Arthroplasty Patients Pauline Walsh, James Broderick, Kevin J Mulhall Poster No. 1272 Effect of Prostaglandin E1 on entrapment neuropathy of diabetic rats Tadahiro Natsume, Takanobu Nishizuka, Hideyuki Oota, Michiro Yamamoto, Hitoshi Hirata Poster No. 1282 Intracellular Activation of Matrix Metalloproteinase-2 in Skeletal Muscle Ischemia-Reperfusion Injury Heejae Kang, Hubert Kim, David Lovett, Xuhui Liu Poster No. 1273 Clinical Translation of a Keratin Biomaterial Hydrogel for Nerve Repair Lauren Pace, Paulina S Hill, Jeffrey Garrett, Jianjun Ma, Peter J Apel, Sandeep Mannava, Jonathan Barnwell, Beth Smith, Zhongyu Li, L. Andrew Koman, Thomas Smith, Mark Van Dyke Poster No. 1274 The Effects of Strain and Displacement Rate on Spinal Nerve Injury and Recovery Chaoyang Chen, Gurjiwan Virk, Joseph Yaldo, Deepti Guruprakash, Katsumasa Tanimoto, Srinivasu Kallakuri, John M Cavanaugh Poster No. 1275 A Novel Flexible Nerve Guidance Conduit with micro-channels in Animal Models Josephine Wing Yuk Ip, Wai Man Choy, Kelvin Wai Kwok Yeung, Jian Yang Poster No. 1276 Diverse Skeletal Muscle Adaptation to Limb Lengthening between Adult and Young Animals Mitsuhiko Takahashi, Daisuke Seto, Yasushi Goto, Hiroki Sakamoto, Kohei Nishioka, Tetsuya Enishi, Natsuo Yasui Poster No. 1277 Whole Body Vibration Restores Skeletal Muscle Remodeling and protects against disuse atrophy in Rats Chia-Hsin Chen, Chau-Zen Wang, Me-Lin Ho, Mao-Hsiung Huang, YanHsiung Wang Poster No. 1278 The Effect of Transcutaneous Carbon Dioxide Application on the Recovery from Muscle Fatigue Yoshitada Sakai, Masahiko Miwa, Keisuke Oe, Takeshi Ueha, Sang Yang Lee, Akihiro Koh, Takahiro Niikura, Ryosuke Kuroda, Masahiro Kurosaka 118 Poster No. 1283 Inhibitory Effect of NF-ΚB Using Technique of Synthetic DoubleStranded Oligodeoxynucleotide for Tissue Necrosis Following Ischemia-Reperfusion Injury Takeshi Uemura, Masaya Tsujii, Koji Akeda, Haruhiko Satonaka, Kazuichiro Hori, Takahiro Iino, Kozo Fujisawa, Akihiro Sudo Poster No. 1284 Notch signaling correlates with the regeneration potential of dystrophic muscle - a comparison study of muscle cells isolated from DMD patients and mdx mice Xiaodong Mu, Koji Takayama, Ying Tang, Bing Wang, Kurt R Weiss, Johnny Huard Poster No. 1285 Biochemical Diversity of Human Skeletal Muscle Timothy F Tirrell, Mark S Cook, John A Carr, Anthony J Choi, Evie Lin, Mary C Esparza, Sam Ward, Richard L Lieber Poster No. 1286 Distinctive expression patterns of collagen VI chains in human skeletal muscle Cathleen Moscibrocki, Aurelie Snyder, Jamie Fitzgerald Poster No. 1287 Dysregulated Wnt and Notch signaling plays a role in the low muscle regeneration observed in Dystrophin/Utrophin double knockout (dko) mice Xiaodong Mu, Koji Takayama, Ying Tang, Bing Wang, Kurt R Weiss, Johnny Huard PS1 Ligament & Tendon Mechanics Poster No. 1288 Ultrasound analysis quantifies mechanical compromise in collagenase model for tendinopathy Sarah Duenwald-Kuehl, Connie Chamberlain, Hirohito Kobayashi, Roderic Lakes, Ray Vanderby Poster No. 1290 Local Differences in Collagen Fiber Crimp Throughout Mechanical Testing in a Mouse Supraspinatus Tendon Model Kristin S Miller, Brianne K Connizzo, Jennica J Tucker, Elizabeth Feeney, Nicholas R Trasolini, Louis J Soslowsky Poster No. 1291 Material Properties Vary Anterior to Posterior in the Human Supraspinous Ligament Daniel J Robertson, Rachel J Willardson, Aaron Cannon, Ashutosh Parajuli, Anton E Bowden Poster No. 1292 Subscapularis Footprint Anatomy Revisited with a 3-Dimensional Perspective and its Relationship with the Supraspinatus Jae Chul Yoo, Bong Jae Jun, Sang Jin Shin, Michelle H McGarry, KyungChil Chung, Thay Q Lee Poster No. 1293 The Biomechanical Relevance of Rotator Cable Tears in a Cadaveric Shoulder Model Mena M Mesiha, Scott C Sibole, Ahmet Erdemir, Kathleen A Derwin, Jesse A McCarron Poster No. 1294 The Effect of Cyclic Axial Loading on Bone Remodeling at the Bone-Tendon Interface in an In-Vivo Animal Model: a Micro-Computed Tomographic and Histological Analysis Clifford Voigt, Michael C Ciccotti, Saif Alzoobaee, John Solic, Carl Imhauser, Joseph Nguyen, Liang Ying, Mark Stasiak, Alice Fox, XiangHua Deng, Saadiq El-Amin, Scott Rodeo Poster No. 1295 Biomechanical Characteristics of the Horizontal Mattress Stitch:Implication for Double-row and Suture-bridge Rotator Cuff Repair Teruhisa Mihata, James Hwang, Mallika Tamboli, Mitsuo Kinoshita, Thay Q Lee Poster No. 1296 Dorsal/Volar Compressive Stiffness of the Transverse Carpal Ligament Erin K Main, Jessica E Goetz, Thomas E Baer, Thomas Brown Poster No. 1297 Measurement of Robotically Applied Strain in the Medial Ulnar Collateral Ligament Muturi Muriuki, Daniel J Petersen, Amin M Motlagh, Patrick J DeMeo, Sam Akhavan, Patrick Smolinski, Mark Carl Miller Poster No. 1298 Does Loading Velocity Affect Failure Strength after Tendon Repair? Manoj Parimi, Chunfeng Zhao, Andrew Thoreson, Kai-Nan An, Peter Amadio Poster No. 1299 Changes in Core Suture Geometry within Repaired Flexor Tendons: an X-ray Evaluation Tim S Peltz, Roger Haddad, Peter Scougall, Sean Nicklin, Jeremy Hunt, MArk Gianoutsos, Matt Pelletier, Nicki Bertollo, William Walsh Poster No. 1300 Effects of Different Temperatures, Velocities and Loads on the Gliding Resistance of Flexor Digitorum Profundus Tendons in a Human Cadaver Model Tamami Moriya, Takako Chikenji, Andrew Thoreson, Chunfeng Zhao, KaiNan An, Peter Amadio Posters Poster No. 1289 Collagen Fiber Re-Alignment in a Neonatal Developmental Mouse Supraspinatus Tendon Model Kristin S Miller, Brianne K Connizzo, Jennica J Tucker, Louis J Soslowsky Poster No. 1301 Suture Preloading Reduces Gap Formation after Flexor Tendon Repair Matthias Vanhees, Andrew Thoreson, Peter Amadio, Kai-Nan An, Chunfeng Zhao Poster No. 1302 Ultrasound Assessment of Motion Patterns of Human Flexor Digitorum Superficialis and Profundus Tendons with Speckle Tracking Y. Yoshii, J. Henderson, H. Villarraga, C. Zhao, K. An, P. Amadio Poster No. 1303 The Role of Lubricin in Intrasynovial Tendon Gliding Masanori Hayashi, Andrew Thoreson, Chunfeng Zhao, Kai-Nan An, Gregory Jay, Matthew Warman, Takako Chikenji, Peter Amadio Poster No. 1304 Modeling to Evaluate the Mechanical Properties of Scapholunate Ligament by Using Canine Model Yi-Hung Ho, Yuan-Kun Tu, Chih-Kun Hsiao, I-Hsien Chen, Chih-Han Chang Poster No. 1305 Age-Related Changes Influence the In Vivo Biomechanical Properties of the Rat Gastrocnemius-Achilles Muscle-Tendon Unit Johannes F Plate, Patrick Haubruck, Walter F Wiggins, Joel D Stitzel, Zhongyu Li, Thomas L Smith, Christopher J Tuohy, Sandeep Mannava Poster No. 1306 Regular interval mechanical characterization tests at physiological amplitude can affect tissue response to mechanobiological stimuli Yoan Lemieux-LaNeuville, Leila Jafari, Denis Gagnon, Eve Langelier Poster No. 1307 Microlevel Ligamentous Insertions Into Bone Lei Zhao, Ashvin Thambyah, Kelly Vince, Broom Neil Poster No. 1308 Age-Related Changes in Tendon Mechanical Properties are Not Enhanced by the Absence of Biglycan and Decorin Mark R Buckley, Lydia Pathmanathan, Michael J Mienaltowski, Andrew A Dunkman, Akash Kumar, David P Beason, Renato V Iozzo, David E Birk, Louis J Soslowsky 119 Posters Poster No. 1309 A New Experimental System for the Study of Tenocyte Mechanobiology Eijiro Maeda, Yasuhumi Hagiwara, James H Wang, Toshiro Ohashi Poster No. 1310 Nonlinear Viscoelasticity is Requisite to Simultaneously Describe Static and Dynamic Ligament Mechanics Kevin Troyer, Christian Puttlitz Poster No. 1311 A Tendon Fascicle Model of Fatigue Injury for the Investigation of Matrix Damage Mechanisms and Intrinsic Cellular Responses to Cyclic Loading Stephen J Ros, Nelly Andarawis-Puri, Evan L Flatow Poster No. 1312 Effects of Hydration on Nanoscale Structural Morphology and Mechanics of Individual Type I Collagen Fibrils Joseph M Wallace, Chad Harding, Arika Kemp Poster No. 1313 Blockade of Substance P signaling does not impair recovery of injured ligament biomechanical properties in rabbits Christopher J DeSutter, Kelsie Court, Catherine Leonard, Gail Thornton, Ryan Martin, Robert C Bray, Paul Ackermann, Paul Salo Poster No. 1314 Stem Cell Loaded Sutures Improve Tendon Healing and Repair Strength in a Rat Model Samuel B Adams, Margaret Thorpe, Brent Parks, Gary Aghazarian, Elizabeth Allen, Lew C Schon PS1 Ligament & Tendon Biology Poster No. 1315 Expression Patterns of Tenogenic Markers Following Full-Length Patellar Tendon Injury Nathaniel Dyment, Namdar Kazemi, Chia-Feng Liu, Lindsey AschbacherSmith, Keith Kenter, Andrew Breidenbach, Jason Shearn, Christopher Wylie, David Butler Poster No. 1316 Distribution of ADAMTS5 and Tenascin-C in the Synovial Tissues around the tendon in the Rotator Cuff Injury Takahiro Iino, Toru Wakabayashi, Masaya Tsujii, Takeshi Uemura, Haruhiko Satonaka, Masahiro Hasegawa, Akihiro Sudo Poster No. 1317 Dysregulation of prostanoid synthesis with injury in flexor tendons Stephanie G Dakin, Jayesh Dudhia, Natalie J Young, Dilkush R Abayasekara, Peter Clegg, Roger K Smith Poster No. 1318 The Influence of VEGF-Releasing Sutures on Blood Vessel Formation by the Healing Ligament Connie S Chamberlain, Ellen M Leiferman, Jae Sung Lee, Ray Vanderby, William L Murphy 120 Poster No. 1319 Effect of Injury and Resultant Mechanical Environment on Matrix Gene Expression in the Human Anterior Cruciate Ligament: Is Ligament Repair Biologically Feasible? Erik Attia, Haydee Brown, Jo Hannafin Poster No. 1320 Mechanisms of Tendon Healing and Matrix Metabolism Induced by Low-Level Laser Therapy YH Chao, YC Huang, YH Tsuang, Jui-Sheng Sun, MH Chen, Cheng Kung Cheng Poster No. 1321 The Effect of Bone Morphogenetic Protein 2 on Tendon-to-Bone Healing in a Canine Flexor Tendon Model Stavros Thomopoulos, H. M Kim, Matthew J Silva, Eleni Ntouvali, Cionne N Manning, Ryan Potter, Howard Seeherman, Richard H Gelberman Poster No. 1322 Effect of local administration of low dose simvastatin-conjugated gelatin hydrogel on tendon-bone healing in anterior cruciate ligament reconstruction using a rabbit model Shinya Oka, Tomoyuki Matsumoto, Seiji Kubo, Takehiko Matsushita, Hiroshi Sasaki, Nishizawa Yuichiro, Tokio Matsuzaki, Yasuhiko Tabata, Masahiro Kurosaka, Ryosuke Kuroda Poster No. 1323 Elution of Growth Factor from Platelet-Rich Plasma-Coated Sutures Delivery for Augmentation of Zone II Flexor Tendon Repairs Duretti Fufa, Michael Gott, Andrew Greenberg, Pasquale Razzano, Nadeen O Chahine, Ashley Olson, Scott Wolfe, John Schwartz, Marisa Gianfortune, Daniel A Grande Poster No. 1324 In vivo response of a biodegradable ACL screw out to 104 weeks William R Walsh, Yan Yu, Rema Oliver, Arthur Galea, Karen Bovid, Warwick Bruce, Tithi DuttaRoy Poster No. 1325 Effect of Timing and Magnitude of Mechanical Loading on TendonBone Tunnel Healing in a Rat Model Clifford Voigt, John Solic, Saif Alzoobaee, Michael C Ciccotti, Carl Imhauser, Joseph Nguyen, Mark Stasiak, Alice Fox, Xiaodong Ju, XiangHua Deng, Saadiq El-Amin, Scott A Rodeo Poster No. 1326 The effects of alendronate on tibial bone tunnel enlargement: an experimental rabbit model Takeshi Kamiya, Hirotaka Shinjo, Ichiro Owan, Fuminori Kanaya, Masako Ito, Akemi Ito Poster No. 1327 Peri-tunnel Bone Loss did not Critically Affect the Early Stage of Tendon Graft to Bone Tunnel Healing Yuk Wa Lee, Pauline Po Yee Lui, Tsui Yu Mok, Yau Chuk Cheuk, Kai Ming Chan Poster No. 1328 Cell Migration after Synovial Graft Interposition at Tendon Repair Site Masanori Hayashi, Chunfeng Zhao, Kai-Nan An, Peter Amadio Poster No. 1340 Tendon-derived Stem Cells (TDSCs) Isolated from the Collagenaseinduced Failed Healing Model of Tendinopathy Exhibited Higher Sensitivity to the BMP/Smad Signaling Pathway Yin Mei Wong, Pauline Po Yee Lui, Yunfeng Rui, Kai-ming Cavor Chan Poster No. 1330 Platelet-Rich Plasma Enhances Proliferation, Matrix Gene Expression, and Synthesis of Degenerative Tenocytes from Torn Human Rotator Cuff Tendon Chris H Jo, Ji Eun Kim, Sue Shin, Kang Sup Yoon Poster No. 1341 Histological analysis on the tendon-to-bone healing utilizing bone marrow-derived MSCs in ACL Reconstruction model without a bone tunnel Tomonoshin Kanazawa, Takashi Soejima, Koji Noguchi, Kousuke Tabuchi, Megumi Noyama, Kensei Nagata Poster No. 1331 Effect of low- intensity resistance training combined with restricted venous blood flow on semitendinosus tendon maturation after reconstruction of the ACL Rieko Kuramochi, Shota Katsumata, Chu C Hung, Maiko Kudo, Hisako Itakura, Toru Fukubayashi Poster No. 1332 Role of MMP-13 in Muscle Fibrosis after Massive Rotator Cuff Tears Nai Chen Chang, Erik J Kramer, Sanjum P Samagh, Dominique Laron, Givenchy Manzano, Hubert T Kim, Brian T Feeley, Xuhui Liu Poster No. 1342 Role of Bone Marrow-Derived Cells after Rotator Cuff Repair - GFP bone marrow chimeric rat model Yoshikazu Kida, Toru Morihara, Ken-Ichi Matsuda, Hisakazu Tachiiri, Yoshio Iwata, Atsuhiko Yoshida, Kazuhide Sawamura, Hiroyoshi Fujiwara, Mitsuhiro Kawata, Toshikazu Kubo Poster No. 1343 Prevention of Peritendinous Adhesions using Peritoneal Membrane Allograft in Flexor Tendon Repair Egleide Y Elenes, Shawn A Hunter, Greg P Boivin, Richard T Laughlin Poster No. 1333 The Influence of Interleukin-1 Receptor Antagonist on Ligament Healing Connie S Chamberlain, Ellen M Leiferman, William L Murphy, Ray Vanderby Poster No. 1344 Comparison of Regional Biomechanical and BMD Properties Within Human Patellar Tendon Allografts and Effect of Low-Dose Irradiation Rebecca Bell, Adam Yanke, Andrew Lee, Richard Kang, Chad Mather, Elizabeth Shewman, Vincent Wang, Bernard Bach Poster No. 1334 Dosing Effect of Extracorporeal Shockwave on Delayed TendonBone Junction Healing Dick Ho Kiu Chow, Margaret Wan Nar Wong, Pui Kit Suen, Lai Hong Fu, Wing Hoi Cheung, Ling Qin Poster No. 1345 Age Related Changes in the Contractile Properties of Rat Tail Tendons Michael Lavagnino, Keri L Gardner, Brian J Cummings, Steven P Arnoczky Poster No. 1335 Characterization of Tenocytes and their Relationship with Mesenchymal Stem Cells Benjamin Davies, Osnat Hakimi, Lynn Quek, Paresh Vyas, Andrew Price, Andrew Carr Poster No. 1346 Cellular and Extracellular Matrix Changes in Human ACL Aging and Degeneration Akihiko Hasegawa, Hiroyuki Nakahara, Hiroshi Asahara, Mitsuo Kinoshita, James Koziol, Darryl D D’Lima, Martin Lotz Poster No. 1336 Differentiating Between Progenitor Cells of Mouse Achilles Tendon Proper and Epi/Paratenon Michael J Mienaltowski, David E Birk PS2 Bone Mechanics Poster No. 1337 Adipose-Derived Mesenchymal Stem Cells Protect Tendon Fibroblasts from IL-1beta Cionne N Manning, Richard H Gelberman, Shelly Sakiyama-Elbert, Matthew J Silva, Stavros Thomopoulos Poster No. 1338 The Effects of Aging on Mouse Tendon Stem Cells Jianying Zhang, Sen Lin, James H Wang Poster No. 1339 Multilineage differentiation potential of the cells derived from torn human rotator cuff Issei Nagura, Takeshi Kokubu, Yutaka Mifune, Tomoyuki Muto, Hanako Nishimoto, Ryosuke Sakata, Masahiro Kurosaka Posters Poster No. 1329 The Inflammatory Effect of Leukocyte-poor Versus Leukocyte-rich Platelet-Rich Plasma Jason Dragoo, Hillary J Braun, Jennah L Durham, Bethany A Ridley, Steven Arnoczky Poster No. 1347 Microdamage-induced Compositional Changes in Brtl/+ and Wildtype Mice: A Raman Imaging Study Mekhala Raghavan, Mathieu S Davis, Francis W Esmonde-White, Joan C Marini, Albert Shih, Michael D Morris, Kenneth Kozloff Poster No. 1348 Diffuse Microdamage Induced in Cortical Bone in vivo Decreases with Time in the Absence of Bone Remodeling Zeynep Seref-Ferlengez, Oran D Kennedy, Mitchell B Schaffler Poster No. 1349 In Vivo Mesenchymal Stem Cell Proliferation Promoted by Dynamic Fluid Flow Stimulation Minyi Hu, Robbin Yeh, Michelle Lien, Yi-Xian Qin 121 Posters Poster No. 1350 Does matrix-damage influence solute transport in osteocyte lacunarcanalicular system? Bin Wang, Xuanhao Sun, Wen Li, Ozan Akkus, Liyun Wang Poster No. 1351 Anatomical Variability in the Ultrastructure of the Osteocyte Lacunar Canalicular System Christopher Price, William Thompson, Peter Fomin, Samuel Jacobs, Shannon Modla, Kirk Cyzmmek, Catherine B Kirn-Safran, Liyun Wang Poster No. 1352 Acute Focal Microdamage Induces Intracortical Bone Remodeling in Mouse Long Bones Without Evoking a Periosteal Woven Bone Response Oran Kennedy, Anaya Philip, Matin Lendhey, Peter Mauer, Jelena BastaPljakic, MItch B Schaffler Poster No. 1353 Microscopic Tissue Damage Forms Preferentially Near Resorption Cavities in Human Vertebral Cancellous Bone Craig R Slyfield, Evgeniy V Tkachenko, Samuel E Fischer, Katherine M Ehlert, Michael G Jekir, Ivana H Yi, Ralph G O’Brien, Tony M Keaveny, Christopher J Hernandez Poster No. 1354 Determination of the Bone Lacunar Canalicular Permeability by Harmonic Loading Mohammed Benalla, Luis Cardoso, Stephen C Cowin Poster No. 1355 Periosteum Permeability Exhibits Mechanically Responsive and Direction Dependent Behavior Sarah F Evans, Jonathan Parent, Melissa L Knothe Tate Poster No. 1356 Remodeling in Periosteum Denuded Bone Abigail Erinc, Favia Merritt, Ulf Knothe, Melissa L Knothe Tate Poster No. 1357 Gender Difference in the Cytochrome P4503A Activity and its Correlation with the Development of Osteonecrosis in Steroid-treated Rabbits Satoshi Ikemura, Takuaki Yamamoto, Goro Motomura, Ryosuke Yamaguchi, Garida Zhao, Kenyu Iwasaki, Yukihide Iwamoto 122 Poster No. 1361 Elastic Anisotropy of Human Cortical Bone Predicted Using a Multiscale Micromechanical and Finite Element Model Andrew Baumann, Justin Deuerling, David Rudy, Glen L Niebur, Ryan Roeder Poster No. 1362 Effects of HIV Infection on the Biomechanical Properties of Bone Jason Wang, Yazdan Raji, Xian Fan, David M Guidot, M. Neale Weitzmann, Tamim Diab, Robert E Guldberg Poster No. 1363 The morphologic factors affecting the BMD of proximal femur in hemi-lateral osteoarthritis of the hip Naoyuki Iwamoto, Yutaka Inaba, Naomi Kobayashi, Takashi Ishida, Yohei Yukizawa, Hyonmin Choe, Hiroyuki Ike, Tomoyuki Saito Poster No. 1364 Cortical and Trabecular Bone Composition: A Hierarchical Analysis Lorenzo Anez-Bustillos, H. Krigman, Shima Aran, G. Spoerri, Brian D Snyder, Ara Nazarian Poster No. 1365 The Effects of Crystallinity on Whole Bone and Tissue Level Mechanical Properties and Composition Grace Kim, Shefford Baker, Adele L Boskey, Marjolein van der Meulen Poster No. 1366 Pre-strain Status and Structural Integrity of Bone Mineral Crystals in Different Loading Modes Bijay Giri, Jonathan D Almer, Xuanliang N Dong, Xiaodu Wang Poster No. 1367 Assessment of osteonal and interstitial bone quality using a novel custom-made microscope-indenter assembly Atharva Poundarik, Alexander Proctor, Deepak Vashishth Poster No. 1368 Development of a Trabecular Bone Stress Relaxation Algorithm Dane Dabirrahmani, Michael C Hogg, Walter Schmidt, Joseph L Racanelli, Ronald M Gillies Poster No. 1369 Hansen’s Hydrogen Bonding Potential of Bathing Solution Modifies Elastic Modulus and Whitening of Demineralized Bone Matrix Matthew Soicher, Michael R Hardisty, Tanya Garcia-Nolen, Susan Stover, David P Fyhrie Poster No. 1358 Sexual Dimorphism Leads to Variation in Mechanical Functionality in the Vertebral Body of Adult Recombinant Inbred Mice Meghan E Faillace, Melissa Ramcharan, Valerie Williams, Steven Tommasini, Karl Jepsen Poster No. 1370 Independent effects of mean and standard deviation of Young’s modulus on cracking of bone Crystal Tjhia, Roger R Zauel, Susan M Stover, Clarita V Odvina, D. Sudhaker Rao, David P Fyhrie Poster No. 1359 Bone Volume is Not Altered with Unloading in the Homozygous Sclerostin Knockout Mouse Alyson Morse, Michelle M McDonald, Ina Kramer, Michaela Kneissel, Natalie Kelly, Katherine Melville, Marjolein van der Meulen, David G Little Poster No. 1371 Trabecular Mineralization in Response to Dynamic Hydraulic Stimulation Using Static and Dynamic Histomorphometry Minyi Hu, Jiqi Cheng, Yi-Xian Qin Poster No. 1360 Morphology-elasticity relationships of human trabecular bone in three major anatomical locations Thomas Gross, Dieter H Pahr, Philippe K Zysset Poster No. 1372 Microdamage in Human Femoral Trabecular Bone Depends on Loading Mode and Pre-existing Damage Ziheng Wu, Glen L Niebur Poster No. 1384 WITHDRAWN Poster No. 1374 Calcium- and Phosphorus-Supplemented Diet Increases Bone Mass and Structural Strength in Exercising Mice Michael A Friedman, Matthew J Rondon, Alyssa M Bailey, David H Kohn Poster No. 1385 The Effect of Mechanical Stimulation on Osteocyte ChemoSensitivity Jia Ning Zhang, Chao Liu, Lidan You Poster No. 1375 Mechanical Loading Causes Detectable Changes in Microstructural Heterogeneity of Cancellous Bone Yener Yeni, Brenda Wu, Lily Huang, Daniel Oravec Poster No. 1386 Multi-scale Computational Modelling of Physiological Loading on Bone Cells Stefaan Verbruggen, Laoise M McNamara PS2 Publications Poster No. 1387 Is Shear Stress the Anabolic Signal in Bone Marrow During LowMagnitude High-Frequency Vibration? Thomas R Coughlin, Evelyn Birmingham, Peter E McHugh, Glen L Niebur Poster No. 1376 An Increase of Foreign Contributions to the Journal of Bone & Joint Surgery over the Last 30 Years Michael S Reich, Jeremy Shaw, Ian Barrett, Victor M Goldberg, Erik Schnaser Poster No. 1377 Reporting and Methodological Quality of Systematic Reviews in the Orthopaedic Literature Patrick Kellam, Joel Gagnier Poster No. 1378 Residents Can Determine the Level of Evidence of Orthopaedic Papers Brian Cunningham, Jason Patterson, Alex McLaren, Ryan McLemore Poster No. 1379 Methodological Quality of Randomized Control Trials in Recent Orthopaedic Literature Laura Chess, Joel Gagnier PS2 Cell & Molecular Biomechanics - Physical Ef fects on Cells Poster No. 1380 Oscillatory Fluid Flow Influences the Number of Microtubules Attached to the Base of Primary Cilia Lina C Espinha, Christopher R Jacobs, David A Hoey Poster No. 1381 Cyclosporin A Synergistically Enhances Acute Gene Expression and Differentiation in MC3T3-E1 Cells Subjected to Dynamic Fluid Flow Leah Worton, Ron Y Kwon, Edith M Gardiner, Ted S Gross, Sundar Srinivasan Poster No. 1382 PTH Enhances Fluid Flow Induced-ERK1/2 Activation in Osteoblastic Cells Yanghui Xing, Jun You Poster No. 1383 Biologic Response of Rat Intervertebral Disc to Dynamic Compression -Analysis of Mechanoreceptors in Dynamic Organ Culture System Takuto Kurakawa, Kenichiro Kakutani, Yusuke Morita, Toru Takada, Koichiro Maeno, Takashi Yurube, Zhongying Zhang, Junya Yamamoto, Hiroaki Hirata, Minoru Doita, Masahiro Kurosaka, Kotaro Nishida Posters Poster No. 1373 WITHDRAWN Poster No. 1388 Shear Injury of Subsynovial Connective Tissue Affects Its Cell Activity Yu-Long Sun, Matthias Vanhees, Chunfeng Zhao, Kai-Nan An, Peter Amadio Poster No. 1389 The Relationship between Temperature and Lubricin Expression Akira Sekiguchi, Koshi N Kishimoto, Taku Hatta, Hiroshi Okuno, Taku Oyanagi, Hiroshi Ozawa, Eiji Itoi Poster No. 1390 Oscillatory Fluid Flow Increases Expression of Inversin in Mesenchymal Stem Cells An M Nguyen, Christopher R Jacobs Poster No. 1391 Hydrostatic pressure plays a role in both the induction and maintenance of a chondrogenic phenotype in joint tissue derived stem cells Tatiana Vinardell, Rebecca A Rolfe, Conor T Buckley, Eric Meyer, Paula Murphy, Daniel Kelly Poster No. 1392 Validation of Fluctuation Correlation Spectroscopy-Based Methods for the Study of Interstitial Flow in Musculoskeletal Tissues Christopher Price, Xiaozhou Zhou, Kirk Cyzmmek, Liyun Wang Poster No. 1393 In Vivo Quantification and Mathematical Description of Osteogenesis in Tissue Engineering Scaffold Alireza Roshan-Ghias, Arne Vogel, Lalao Rakotomanana, Dominique P Pioletti Poster No. 1394 Bone Functional Adaptation Stimuli under Direct Deformation using a Reverse Engineering Approach Michael Liebschner, Matthew Wettergreen, Brandon Bucklen 123 PS2 Bone Fracture Posters Poster No. 1395 The Role of the Progressive Ankylosis Protein (ANK) in Bone Fracture Healing Martin Quirno, Scott Hadley, Takeshi Minashima, Joseph Giovinazzo, Kirk Campbell, Thorsten Kirsch Poster No. 1396 Prefabrication of a vascularized allograft bone in a recipient rat The combined administration of basic fibroblast growth factor and bone marrow-derived mesenchymal stromal cells to stimulate bone formation in the transplanted bone Yoshio Kaji, Osamu Nakamura, Yasuhiko Imaizumi, Tetsuji Yamamoto Poster No. 1397 Effects of 11kGy Gamma Irradiation on Osteoinductivity of Demineralized Bone Matrix Yan Yu, May Wong, Jia-Lin Yang, Tracey A Woolford, David A Morgan, William R Walsh Poster No. 1398 Toward the Characterization of Altered Signaling Pathways in an Aged Mouse Model of Fracture Healing Nicole S Belkin, Chancellor F Gray, Michael R Karp, Derek Dopkin, Michael Dishowitz, Kurt D Hankenson, Jaimo Ahn Poster No. 1399 Contrasting Sub-critical and Critical Murine Femoral Defects: Injury of a Non-union model Brian M Grawe, Aditya Chaubey, Nat Dyment, Jason A Inzana, Xi Jiang, Camille Connolley, Steven A Goldstein, Hani A Awad, David W Rowe, Keith Kenter, David L Butler Poster No. 1406 The Effect of Low-intensity Pulsed Ultrasound (LIPUS) Fields on Osteocyte-Osteoblast Interactions Chak Hei Fung, Kwok Sui Leung, Wing Hoi Cheung Poster No. 1407 The Effect of Photodynamic Therapy (PDT) on Long Bone Fracture Healing Margarete K Akens, David Wright, Sadiya Yousef, Diane Nam, Albert J Yee, Brian C Wilson, Cari M Whyne Poster No. 1408 A Novel In Vitro Model of Chondrocyte Response to Impact with or without Articular Fracture Josef A Stolberg-Stolberg, Bridgette D Furman, Louis E DeFrate, N. W Garrigues, Farshid Guilak, Steven A Olson Poster No. 1409 The Effect of Addition of Unprocessed Bone Marrow clot in the Bone Healing Response in a Canine Multi Femoral Defect Animal Model Viviane Luangpphakdy, Kentaro Shinohara, Hui Pan, Cynthia Boehm, George F Muschler Poster No. 1410 Functional Outcome of Surgically Treated Lateral Compression Pelvic Injuries Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1400 Evaluation of Fracture Healing and Osseointegration: a Rat Tibia Model for Non-invasive Raman Spectroscopy Paul I Okagbare, Francis W Esmonde-White, Dana L Begun, Steven A Goldstein, Michael D Morris Poster No. 1411 Cortical Porosity in Type-2 Diabetic Postmenopausal women with and without fragility fractures Samuel P Yap, Janina Patsch, Andrew Burghardt, Ann Schwartz, Thomas Link Poster No. 1401 Functional Roles of Macrophages during Fracture Repair Yan Yiu Yu, Theodore Miclau, Ralph Marcucio Poster No. 1412 The Assessment of Cervical Hip Fracture Risk from Radiographs: a Prospective Study Jukka Hirvasniemi, Pasi Pulkkinen, Mikko Määttä, Jerome Thevenot, Raija Korpelainen, Simo Saarakkala, Timo Jämsä Poster No. 1402 Transcutaneous application of CO2 accelerates fracture repair in Rat Takaaki Koga, Takahiro Niikura, Sang Yang Lee, Akihiro Koh, Yoshihiro Dogaki, Estuko Okumachi, Takeshi Ueha, Yoshitada Sakai, Keisuke Oe, Ryosuke Kuroda, Masahiko Miwa, Masahiro Kurosaka Poster No. 1403 Negative Pressure Wound Therapy for the Repair of Critical-Sized Segmental Bone Defects Asya Bakhtina, Peter Michael, Marieme Dembele, Timothy Buirkle, Saariga Uma, Treena Arinzeh Poster No. 1404 Gene Expression of Osteoporotic Fracture Healing Augmented by Low-Magnitude High-Frequency Vibration Treatment Shu-lu Chung, Wing Hoi Cheung, Kwok Sui Leung 124 Poster No. 1405 Low Intensity Pulsed Ultrasound Accelerates Fracture Healing through SDF-1/CXCR4 pathway Fang Yuan Wei, Kwok Sui Leung, Gang Li, Ling Qin, Ming Hui Sun, Simon K Chow, Wing Hoi Cheung Poster No. 1413 Clinical Outcome of Tibial Plateau Fractures Related to Meniscal Injuries Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1414 Population-based Incidence of Fractures of the Proximal Radius and Ulna among Adults in a Canadian Urban Centre David M Sheps, Kyle A Kemp, Kevin A Hildebrand Poster No. 1415 Clinical Outcome of Tibial Plateau Fractures Related to Slope of the Tibial Plateau Martin F Hoffmann, Clifford B Jones, Debra L Sietsema Poster No. 1417 Low Physical Activity and Impaired Mobility Are Risk Factors of Hip Fracture in Elderly Women - A 13-year Prospective Population Based Cohort Study Mikko Määttä, Erkki Terho, Heikki Jokinen, Pasi Pulkkinen, Juha Korpelainen, Jorma Heikkinen, Sirkka Keinänen-Kiukaanniemi, Timo Jämsä, Raija Korpelainen Poster No. 1418 Fascia iliaca compartment block for patients with proximal femoral fracture -Prospective evaluation of the efficacy and safety Yuki Fujihara, Juichi Miura, Shoji Nishio, Sahoko Koyanagi, Shigeo Fukunishi, Tomokazu Fukui, Shinichi Yoshiya Poster No. 1419 Subchondral bone remodelling during repetitive, high magnitude stress: Evidence from a thoroughbred racehorse model of articular fatigue fracture Chris Whitton, Michiko Mirams, Ego Seeman, Garry Anderson, Eleanor Mackie PS2 Fracture Fixation Poster No. 1420 Conversion from External Fixator to Intramedullary Nail Impairs Fracture Healing Particularly After a Severe Trauma Stefan Recknagel, Ronny B Bindl, Tim Wehner, Christian Ehrnthaller, Florian Gebhard, Markus Huber-Lang, Lutz Claes, Anita Ignatius Poster No. 1421 Stability of the Proximal Humeral Fracture Treated with Compression, Locking Plating and Inlay Allograft Struts Chih-Kun Hsiao, Cheng-Hong Lee, Feng-Te Tsai, Yi-Jung Tsai Poster No. 1422 Locked Plate Fixation of Proximal Humerus Fractures: Biomechanical Evaluation of Screw to Subchondral Distance and Medial Calcar Support Geoff Abrams, Derek P Lindsey, Nicholas J Giori, Emilie V Cheung, Marc R Safran Poster No. 1423 Biomechanical Analysis of Proximal Radial Shaft Fracture Fixation Greg Gaski, Steven Quinnan, Edward Milne, David Kaimrajh, Loren Latta Poster No. 1424 Volar locking plate versus k-wiring fixation of distal radius fractures in 20-65 year olds Christine Kiernan, Stephen A Brennan, Niall McInerney, Mutaz Jadzan, Stephen Kearns, Michael O’ Sullivan Poster No. 1425 Mechanical advantages of truss-structure-based fracture fixation system Tetsuya Arai, Hitoshi Hirata Poster No. 1426 Viscoplasticity Drives Crack Initiation and Propagation in Crosslinked UHMWPE at Clinically Relevant Notches Pavana A Sirimamilla, Clare Rimnac, Jevan Furmanski Poster No. 1427 Minimally Invasive Posterior Pelvic Bridging Osteosynthesis for Type C Injuries: Biomechanical Evaluation Chris L Anderson, Alexander Chong, Douglas C Pence, Bradley R Dart, Paul H Wooley Posters Poster No. 1416 Effect of Initial Post-operative Visit X-rays on Treatment Plans and Costs Timothy N Ghattas, Bradley R Dart, Anthony Pollock G Pollock, Anh Pham, Stephen Hinkin, Teresa L Jones Poster No. 1428 Biomechanical Study on Internal Fixation of Talar Neck Fractures Jonathan H Capelle, C. G Couch, K. M Wells, R. P Morris, W. L Buford, D. J Merriman, V. K Panchbhavi Poster No. 1429 Dynamization of the Taylor Spatial Frame with Modified Shoulder Bolts Christopher Iobst, Anthony Khoury, Zackery Ingwer, David Kaimrajh, Edward Milne, Loren Latta Poster No. 1430 Can MEMS Accelerometers be used to Directly Monitor Relative Fracture Movement? Sarah Junaid, David Cheneler, Sarvenaz Ghaffari, David W Hukins, Carl J Anthony, Duncan Shepherd Poster No. 1431 Arthroscopic Suture Bridge Fixation of T ibial Eminence Fractures: A New Surgical Technique and Biomechanical Analysis Gregory Sawyer, Brett C Anderson, David J Paller, Jonathan Schiller, Michael J Hulstyn Poster No. 1432 A Biomechanical Evaluation of Locking versus Conventional Fibula Plating for Supination External Rotation Fibula Fractures Jason T Bariteau, Brad Blankenhorn, David Paller, Craig Lareau, Christopher DiGiovanni Poster No. 1433 Comparison of Crossed K-Wire and Mini-Hoffmann Fixation to Small pin, Non-Bridging External Fixation for Distal Metacarpal Fractures Peter J Evans, Ryan Flook, Mohammad Hajianpour, David Kaimrajh, Edward Milne, Loren Latta PS2 Imaging Poster No. 1434 Cone-beam CT in the assessment of tibial bone defect healing: an animal study Marcel Betsch, Mohssen Hakimi, Pascal Jungbluth, Michael Wild, Joachim Windolf Poster No. 1435 Longitudinal Morphometric Analysis of the Hip in Cerebral Palsy using Computed Tomography Shinichi Gose, Takashi Sakai, Toru Shibata, Hideki Yoshikawa, Kazuomi Sugamoto 125 Posters Poster No. 1436 Measurement of Amputee Loaded Stump Volume Using a Novel Turntable-Based Cone-Beam Low-Exposure Computed Tomography Method George Papaioannou Poster No. 1437 Quantifying Amputee Socket Fit Using Computed Tomography Data Justo J Torres, Christopher Papadopoulos, George Papaioannou Poster No. 1438 Accuracy and reproducibility of in-vivo bone morphology and strength assessment at the distal radius with a cast Sandrine Bours, Jacobus J Arts, Paul Willems, Martijn de Kooter, Tineke van Geel, Piet Geusens, Keita Ito, Joop van den Bergh, Bert van Rietbergen Poster No. 1439 Validation of Contrast-Enhanced Computed Tomography for Imaging of Cartilage in Fracture Healing Lauren N Hayward, Chantal M de Bakker, Louis C Gerstenfeld, Mark W Grinstaff, Elise F Morgan Poster No. 1440 Assessment of Axial Bone Rigidity in Rats with Metabolic Diseases using CT-based Structural Rigidity Analysis Vahid Entezari, Michael D Smith, Stephen Baldassarri, Alen Tseng, David Zurakowski, Brian D Snyder, Ara Nazarian Poster No. 1441 Contrast Enhanced Computed Tomography of Human Cartilage in vivo Harri Kokkonen, Antti Aula, Heikki Kröger, Juha-Sampo Suomalainen, Eveliina Lammentausta, Esa Mervaala, Jukka S Jurvelin, Juha Töyräs Poster No. 1442 CT arthrography of the knee to measure cartilage quality with low radiation exposure Jasper V Tiel, Michiel Siebelt, Erwin Waarsing, Marcel V Straten, Jan Verhaar, Gabriel Krestin, Harrie Weinans, Edwin Oei Poster No. 1443 Simultaneous Quantitative Ultrasound Assessment of Cartilage and Subchondral Bone Jukka Liukkonen, Jukka Hirvasniemi, Antti Joukainen, Pekko Penttilä, Tuomas Viren, Jukka S Jurvelin, Juha Töyräs Poster No. 1444 A linear-array based quantitative ultrasound imaging system for bone quality assessment Jiqi Cheng, Frederick Serra-Hsu, Wei Lin, Yi-Xian Qin Poster No. 1445 Clinical Ultrashort TE-Enhanced T2* Mapping of Knee Cartilage at 3T Ashley A Williams, Yongxian Qian, Robin West, Freddie H Fu, Constance R Chu Poster No. 1446 Albumin as a Substrate for Focused Ultrasound Sealing of Engineered Cartilage Adam B Nover, Matthew V Dermksian, Gary Y Hou, Elisa E Konofagou, Gerard A Ateshian, Clark T Hung 126 Poster No. 1447 Ultrasonic evaluation of acute impact injury of articular cartilage Tuomas Viren, Matti Timonen, Hannu Tyrväinen, Virpi Tiitu, Jukka S Jurvelin, Juha Töyräs Poster No. 1448 Quantitative Ultrasound Image Analysis of Femoral Subchondral Bone in Knee Osteoarthritis Jana Podlipská, Juhani Koski, Pasi Pulkkinen, Simo Saarakkala Poster No. 1449 Age-Dependent Changes in Matrix Composition and Organization of the Osteochondral Interface Nora T Khanarian, Adele L Boskey, Helen Lu Poster No. 1450 Semi-Quantitative Analysis of Type II Collagen Distribution in Normal and Repair Cartilage Using Multivariate Analysis of FT-IR Spectra Arash Hanifi, Sally Roberts, Helen S McCarthy, Nancy Pleshko Poster No. 1451 Intraoperative Near-infrared Fluorescence Imaging for Spinal Metastasis Using a Novel Indocyanine Green-Loaded Nanocarrier Toru Funayama, Masataka Sakane, Toshinori Tsukanishi, Tetsuya Abe, Isao Hara, Eiichi Ozeki, Naoyuki Ochiai Poster No. 1452 PTH effects on Calvaria Bone Allograft Healing Process Monitored by In-Vivo Functional Fluorescence Imaging Gadi Pelled, Ilan Kallai, Dmitriy Sheyn, Doron Cohn Yakubovich, Shabtai Or, Susan Su, Anthony Oh, Wafa Tawackoli, Edward Schwarz, Zulma Gazit, Dan Gazit Poster No. 1453 The Role of Tomosynthesis in Evaluating Bone Changes in Rapid Onset Focal Osteoarthritis Fred Nelson, Catherine Lumley Poster No. 1454 Hip Measurements Distinguish Early Hip Subchondral Insufficiency Fractures from Osteonecrosis Fred Nelson, Woods Tammy, Varun Bhandarkar Poster No. 1455 How Does a Mal-positioned X-Ray Affect ACL Insertion Site Identification? Robert E Carey, Jonathan R Bumstead, Gele Moloney, Snehal Shetye, Paulo Araujo, Christopher D Harner, Xudong Zhang Poster No. 1456 Morphological Measurement on Anteroposterior Pelvic Radiographs - The Effect of Tilt and Rotation Huw Williams, Geraint Thomas, Stephen J Mellon, Sion Glyn-Jones, M. K Javaid, Nigel K Arden, Simon Ostlere, H. S Gill Poster No. 1457 Raman Spectroscopy: a novel method for the detection of molecular changes in osteoarthritis Jemma Kerns, Panagiotis Gikas, Jonathan Perera, Kevin Buckley, Adam Shepperd, Helen Birch, Ian McCarthy, Jonathan Miles, Tim Briggs, Anthony W Parker, Pavel Matousek, Allen Goodship Poster No. 1459 Macrophage migration inhibitory factor up-regulates αVβ3 integrin expression and cell migration via PI3K, Akt and NF-kappa-Bdependent pathway in human chondrosarcoma cells Mei-Ju Su, Chih-Hsin Tang Poster No. 1470 Inhibition of Osteosarcoma metastasis by Insulin-like Growth Factor Binding Protein 5 (IGFBP5) Gaurav Luther, Richard Rames, Eric R Wagner, Rex Haydon, Tong-Chuan He, Hue Luu Poster No. 1460 Runx2 Regulates p16 Expression in Chondrosarcoma Cells Richard M Terek, Xiaojuan Sun Poster No. 1471 Hsp90 inhibitor induced autophagy and apoptosis in osteosarcoma cells Masaki Mori, Toshiaki Hitora, Osamu Nakamura, Yoshiki Yamagami, Tetsuji Yamamoto Poster No. 1461 BDNF increases human chondrosarcoma cells migration and β5 integrin expression via TrkB, PI3K/Akt and NF-κB dependent pathways Chih-Yang Lin, Chih-Hsin Tang Poster No. 1462 CTGF confers drug resistance in human osteosarcoma cells through ERK1/2-dependent Bcl-xL/survivin up-regulation Hsiao-Chi TSAI, Hong-Lin Su, Chun-Yin Huang, Chih-Hsin Tang Poster No. 1463 Protein Kinase D1 Negatively Regulates Invasion and Migration Ability of Human Osteosarcoma Cells Yasuo Onishi, Teruya Kawamoto, Hitomi Hara, Naomasa Fukase, Mitsunori Toda, Risa Harada, Masahiro Kurosaka, Toshihiro Akisue Poster No. 1464 Vancomycin Inhibits Proliferation of Osteosarcoma Cells In vitro Ryan P Dunlay, Shanshan Wang, Terence E McIff, Rama Garimella, Kimberly J Templeton Poster No. 1465 Pharmacological inhibition of Hedgehog pathway prevents human osteosarcoma growth Shunsuke Nakamura, Hiroko Nagao, Setsuro Komiya, Takao Setoguchi Poster No. 1466 Expression of Extracellular Matrix Metalloproteinase Inducer is Correlated with Prognosis of Patients with High Grade Extremity Osteosarcoma Naohisa Futamura, Yoshihiro Nishida, Hiroatsu Nakashima, Hiroshi Urakawa, Eisuke Arai, Eiji Kozawa, Satoshi Tsukushi, Naoki Ishiguro Poster No. 1467 mTOR Inactivation Reduces Motility and Proliferation In Murine Osteosarcoma Cells Xiaodong Mu, Christian Isaac, Riddhima Agarwal, Johnny Huard, Kurt R Weiss Poster No. 1468 SAMD9L Promotes Proliferation and Tumor Initiating Cell Population in Osteosarcoma Elaine Mau, Qingxia Wei, Kandel Rita, Wunder Jay, Benjamin Alman Posters Poster No. 1458 HGF increases migration and MMP-2 expression via PI3K, AKT and NF-kappaB dependent pathway in human chondrosarcoma cells Ya-Hui Hung, Tzu-Wei Tan, Chih-Hsin Tang Poster No. 1469 Molecular Mechanisms Regulating the Phenotype of Cancer StemLike Cells of Osteosarcoma Tomohiro Fujiwara, Nobuyoshi Kosaka, Ryou-u Takahashi, Fumitaka Takeshita, Akira Kawai, Toshifumi Ozaki, Takahiro Ochiya PS2 Cancer/Tumors Poster No. 1472 Mechanism of Osteosarcoma Tumorigenesis by S100A4 Gaurav Luther, Eric R Wagner, Richard Rames, Rex Haydon, Tong-Chuan He, Hue Luu Poster No. 1473 Cytotoxicity Testing using an In Vitro Three-Dimensional Osteosarcoma Model Pamela H Tan, Khin Z Aung, Siew Lok Toh, James C Goh, Saminathan Suresh Nathan Poster No. 1474 The Synergistic Tumor Micro-environmental Effect of Extracellular pH, pO2, and Pressure controlled Invasiveness and Survival on Human Osteosarcoma Cells Takao Matsubara, Gene R DiResta, John H Healey Poster No. 1475 Targeting Neuropilin, A VEGF Receptor, Reduces Angiogenesis and Tumor Growth in Osteosarcoma Kap Jung Kim, Toshinori Sakai, Ramez Eskander, Yi Guo, Peter McQueen, Samia Ghaffar, Kevin Rooney, Carol H Lin, Xiaolin Zi, Bang H Hoang Poster No. 1476 Y-box binding protein-1 regulates tumor growth and associates with clinical prognosis of osteosarcoma Yuko Okada, Yoshihiro Matsumoto, Jyunichi Fkushi, Toshifumi Fujiwara, Keiichirou Iida, Mihoko Koga, Yoshinao Oda, Hisakata Yamada, Yukihide Iwamoto Poster No. 1477 Surface proteomic analysis of osteosarcoma identifies EPHA2 as receptor for targeted drug delivery Jantine PosthumaDeBoer, Sander R Piersma, Thang V Pham, Victor W van Beusechem, Connie R Jimenez, GertJan L Kaspers, Marco N Helder, Barend J van Royen Poster No. 1478 Transcriptomic & Proteomic Microarray Analyses in Giant Cell Tumor of Bone: Revelation of anti-PTHrP Induced Apoptosis via Cell Cycle Regulation Isabella Mak, Robert Turcotte, Michelle Ghert 127 Posters Poster No. 1479 Fibroblast growth factor receptor-2 induces osteoblast survival and stromal cell differentiation in Giant Cell Tumor of bone Shalini Singh, Isabella Mak, Nadia Khyzha, Robert Turcotte, Michelle Ghert Poster No. 1489 Neonatal Exposure to High Dose Diethylstilbesterol Affects Bone and Articular Cartilage in Adult Male and Female Progeny Sora Al Rowas, Rahul Gawri, Abdul Aziz Al Maawi, John Antoniou, Lorainne E Chalifour, Fackson Mwale Poster No. 1480 Synthesis and Evaluation of NSC23925 Isomers to Reverse Multidrug Resistance in Sarcomas Zhenfeng Duan, Wen Yang, Xianzhe Liu, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek Poster No. 1490 Hrpt2 deletion in osteoblasts improves bone density, geometry and strength in mice Cassie R Zylstra-Diegel, Travis Burgers, Jacob J Baker, Cassie A Schumacher, Pengfei Wang, Bin Teh, Jim Mason, Bart O Williams Poster No. 1481 Novel Bipolar Cooled Radiofrequency (BCRF) Probe Application in a Preclinical Bone Metastatic Model; MR Imaging Implications Padina Pezeshki, Margarete K Akens, Jason Woo, Emily Won, Albert Yee, Cari Whyne Poster No. 1491 Connexin 43 Deficiency in Osteoblasts/Osteocytes Influences Murine Postnatal Shoulder Development Hua Shen, Susan K Grimston, Roberto Civitelli, Stavros Thomopoulos Poster No. 1482 Development of hyperthermia treatment using novel nanoparticle Hidenobu Fukumura, Takeo Hori, Haruki Eguchi, Yoshihiro Ishikawa, Tomoyuki Saito Poster No. 1483 Persistent Disruption of Bone Vascularity Following Localized Bone Irradiation Megan E Oest, Joseph A Spadaro, Timothy A Damron Poster No. 1484 3D planning and navigation accuracy in bone tumor resection Lucas E Ritacco, Federico E Milano, German Farfalli, Fernán Gonzalez Bernaldo de Quirós, Marcelo Risk, Luis Aponte-Tinao Poster No. 1485 CT-Based Structural Rigidity Analysis Improves Specificity Over Mirels Scoring for Fracture Prediction T. A Damron, C. Brown, V. Entezari, A. Nazarian, Brian D Snyder, J. A Hipp, N. Calderon, R. M Terek, E. Y Cheng, A. J Aboulafia, M. A Anderson, M. C Gebhardt Poster No. 1486 Osteoclast Activity Increases Early Following Localized Bone Irradiation Megan E Oest, Brendan Rogers, Joseph A Spadaro, Judith Strauss, Timothy A Damron Poster No. 1487 Cooled Bipolar Radiofrequency Yields Large Contained Areas of Ablation in the Porcine Spine Padina Pezeshki, Jason Woo, Emily Won, Margarete K Akens, Cari Whyne, Albert Yee PS2 Bone Biology Poster No. 1488 Cellular Dysregulation of Gene Expression May Contribute to Matrix Hypermineralization in Osteogenesis Imperfecta Joan C Marini, Wayne A Cabral, Nadja Fratzl-Zelman, Paul Roschger, Klaus Klaushofer, Adele Boskey 128 Poster No. 1492 Putative function of TAP63α during endochondral bone formation Qiping Zheng, Feifei Li, Sam Abbassi, Yaojuan Lu, Ming Ding, Guojun Wu, Siying Wang Poster No. 1493 Disrupted collagen sensing in Integrin α2 deficient mice results in abnormal bone development in aging bone Daniel Kronenberg, Beate Eckes, Melanie Timmen, Heriburg Hidding, Jens Everding, Marvin Peters, Thomas Pap, Michael J Raschke, Richard Stange Poster No. 1494 Osteogenic Potential of an Algorithmically Designed Peptide Anupam Sharma, David Komatsu, Srinivas Pentyala, Michael Hadjiargyrou Poster No. 1495 Changes in Collagen Structure in Bone and Tail Tendon From Diabetic Rats Revealed By Atomic Force Microscopy Joseph M Wallace, Max Hammond, Max Gallant, David B Burr Poster No. 1496 Calcium Isotopes Used as Markers of Bone Formation and Bone Turnover Nicole Collette, Darren Hillegonds, Kenneth Turteltaub, Gabriela Loots Poster No. 1497 Osteocyte Lacunae and Canaliculi in Cortical and Trabecular Bones Xiaohan Lai, Christopher Price, Liyun Wang Poster No. 1498 Stimulation of Sclerostin Expression by Glucocorticoid Hormones: A Mechanism to Explain Steroid-Induced Inhibition of Bone Formation J. Edward Puzas, Emily Resseguie, Eric Beier Poster No. 1499 Sclerostin Antibody Enhances Bone-Implant Contact by Increasing Bone Formation and Inhibiting Bone Resorption John M Irish, Amarjit S Virdi, Kotaro Sena, Min Liu, Hua Z Ke, Dale R Sumner Poster No. 1501 Estrogen receptor and GRP30 contribute to simvastatin-stimulated osteogenic effects on murine bone marrow mesenchymal stem cells SHu-Chun Chuang, Li Fu Chang, Gwo-Jaw Wang, Mei Ling Ho, Je-Ken Chang Poster No. 1502 Icaritin, an Exogenous Phytomolecule, Promotes Osteogenic and Inhibits Adipogenic Differentiation of Mesenchymal Stem Cells Dong Yao, Xinhui Xie, Xinluan Wang, Ling Qin Poster No. 1503 Drug screening for activating the Runx2 promoter and osteoblastic differentiation of mesenchymal stem cells Kenichi Mishima, Hiroshi Kitoh, Naoki Ishiguro, Kinji Ohno Poster No. 1504 The Study of Molecular Mechanisms of Alendronate on Enhancing Osteogenesis in Human Mesenchymal Stem Cells Yu-Fang Chang, Mei-Ling Ho, Je-Ken Chang, Gwo-Jaw Wang Poster No. 1505 The ERK Pathway Links Actin Remodeling for Phagocytosis of Metal Particle and Inflammatory Gene Expression in Osteoprogenitor Cells Heon Goo Lee, Hiroshi Minematsu, Hana Goto, Anny C Hsu, Alan Y Chou, Saqib Nizami, Francis Y Lee Poster No. 1506 The relationship between periprosthetic bone mineral density and bone marrow mesenchymal stromal cell response to osteogenic drugs in patients with total hip arthroplasty Weiping Ren, Nancy M Jackson, Susan Birli, Jeffrey C Flynn, David Markel Poster No. 1507 Non-Enzymatic Glycation is Associated with Markers of Bone Quality in Human Cortical and Cancellous Bone Lamya Karim, Deepak Vashishth Poster No. 1508 A New In Vacuo Glycation Process for Generation of Fluorescent Crosslinks Using Less Reactive Glucose Instead of Ribose Grazyna Sroga, Robert Davignon, Krista Parran, Deepak Vashishth Poster No. 1509 Heterotopic Ossification Following Blast Amputation in Forelimbs and Hindlimbs of a Sprague-Dawley Rat David E Jaffe, David J Yoo, Jason Blevins, Gregory Gasbarro, Tyler Hughes, Ebrahim Paryavi, Vincent D Pellegrini Poster No. 1510 Fast Fourier Transform (FFT) Analysis of Lamellations within Trabecular Bone Packets: Relationships with Animal Maturity, Strain Mode, and Mean Tissue Age John G Skedros, Alex N Knight, Alex J Drew, Alex M Millet, Kent N Bachus, Roy D Bloebaum Posters Poster No. 1500 Adenylyl Cyclase 6 Mediates Bone Adaptation In Vivo Kristen L Lee, David A Hoey, Tong Tang, Kirk Hammond, Christopher R Jacobs Poster No. 1511 An Analysis of Femoral Head Diameters as related to Coxa Magna and Symmetry in a Normal Population of 160 Cadaver Specimens Ernest Young, Daniel R Cooperman, Nicholas U Ahn Poster No. 1512 Osteon Morphotypes and Predominant Collagen Fiber Orientation are Adaptations for Habitual Medial-Lateral Bending in the Human Proximal Diaphysis: Implications for Understanding the Etiology of Atypical Fractures John G Skedros, Kendra E Keenan, Jason A Halley, Alex N Knight, Roy D Bloebaum Poster No. 1513 Healing pattern of reamed bone following bone harvesting by a RIA device Declan M Devine, Daniel Arens, Martin Thalhauser, Damiano Schiuma, Stephan Zeiter, Dirk Nehrbass Poster No. 1514 Altered Bone Marrow Adiposity Following Localized Irradiation Differs in Juvenile and Mature Mice Lihini S Keenawinna, Megan E Oest, Timothy A Damron Poster No. 1515 Micro-Computed Tomography Characterization of the Trabecular Bone Architecture of the Deer Calcaneus: A Potential “Control Bone” for Interpreting Femoral Neck Adaptation and Loading Kristofer D Sinclair, Ryan W Farnsworth, Teresa X Pham, Alex N Knight, Roy D Bloebaum, John G Skedros Poster No. 1516 Multi-planar Visualization of Tibial Bone Density Distribution from a Tibial CAT Scan Dataset Nick Wong, Chih-Shing Wei, Peter S Walker Poster No. 1517 Deriving Ash Fraction from microCT Bone Scans David W Wagner, Derek Lindsey, Gary S Beaupre PS2 Bone - Growth Factors Poster No. 1518 Process of Bone Fusion Using the Combination of Platelet-Rich Plasma and a Gelatin beta-Tricalcium Phosphate Sponge in Posterolateral Fusion Model: Comparison with Autogenous Bone Grafting Shinichi Okamoto, Takumi Ikeda, Kazuhide Sawamura, Masateru Nagae, Yasuo Mikami, Hitoshi Hase, Yasuhiko Tabata, Ken Ichi Matsuda, Mitsuhiro Kawata, Toshikazu Kubo 129 Posters Poster No. 1519 Enhancement of bone regeneration in a rabbit ulnar defect model using a gelatin β-tricalcium phosphate sponge impregnated plateletrich plasma Naotake Yamada, Wook-Cheol Kim, Takashi Yoshida, Yoshinobu Oka, Masahi Nakase, Atsushi Nishida, Shinichi Okamoto, Takumi Ikeda, KenIchi Matsuda, Yasuhiko Tabata, Mitsuhiro Kawata, Toshikazu Kubo Poster No. 1520 Lumbar posterolateral fusion using heparin-conjugated fibrin for sustained delivery of BMP-2 in rabbit model Ki Hyoung Koo, Do Hyun Yeo, Gun-il Im, Byoung-Soo Kim Poster No. 1521 A Promising BMP Delivery System for Muscle Cell-Based Bone Regeneration Hongshuai Li, Noah Johnson, Yadong Wang, Johnny Huard Poster No. 1522 Lower dose of vancomycin in combination with BMP-2 maintains functionality in a S. aureus and bone cell co-culture Sungwoo Kim, Andre Nguyen, Joseph C. Wenke, Yunzhi Yang Poster No. 1523 BMP-2 Induces Bone Formation of Hierarchical Tumor Cell Population in OS99-1 Human Osteosarcoma Cell Line Lin Wang, Huina Zhang, Paul Park, Frank La Marca, Chia-Ying Lin Poster No. 1524 Growth Hormone and IGF-1 Treatment Increase Skeletal Integrity of ALS-null Mice Oran Kennedy, Hayden W Courtland, YingJie Wu, Mordechay Betho-On, Hui Sun, MItch B Schaffler, Shoshana Yakar Poster No. 1525 Effect of Thrombin Source and Dose on the Osteoinductivity of DBM Combined with PRP Jennifer Woodell-May, Trenton Walker, Bo Han Poster No. 1526 Polyelectrolyte multilayer film as bioactive BMP-2 carrier for bone tissue application Delphine Logeart-Avramoglou, Thomas Crouzier, Frédéric Sailhan, Pierre Becquart, Raphael Guillot, Catherine Picart PS2 Bone - Osteoporosis Poster No. 1527 The Measurement of Bone Mineral Density of Bilateral Proximal Humerus - Using DXA in Korean Patients with Unilateral Rotator Cuff Tear Joo Han Oh, Byung Wook Song, Sae Hoon Kim, Seok Won Chung, Yeun Ho Kim, Hye Ran Kim, Shang Mi Shim, Sun Mi Kim, Yun A Oh, Ji Wook Choi Poster No. 1528 The Measurement of 3-Dimensional Block Bone Mineral Density of Bilateral Proximal Humerus - Using Quantitative Computed Tomography in Patients with Unilateral Rotator Cuff Tear Joo Han Oh, Yeon Soo Lee, Byung Wook Song, Kwan Su Kang 130 Poster No. 1529 Parathyroid Hormone Treatment Improves Cortical Bone MicroStructure In Postmenopausal Osteoporosis Maria-Grazia Ascenzi, Vivian Liao, Brittany Lee, Fabrizio Billi, Hua Zhou, Robert Lindsay, Felicia Consman, Jeri Nieves, John Bilezikian, David Dempster Poster No. 1530 Premenopausal Women with Distal Radius Fractures Have Deteriorated Trabecular Bone Density and Morphology Compared to Non-Fracture Controls Mary Bouxsein, Laura Deschamps, Brandon Earp, Alexander Taylor, Charles Day, Tamara Rozental Poster No. 1531 Prediction of Hip Fracture: Combination of WHO Absolute Fracture Risk Model (FRAX) and Proximal Femoral Geometry Hyung-min Ji, Ye-Yeon Won, Jean Kyung Bak, Kyung-Hoi Koo Poster No. 1532 BMD T-score as a predictor for vertebral fracture severity in postmenopausal women Eual Phillips, Chamith Rajapakse, Michael Wald, Felix Wehrli Poster No. 1533 Decreased cortical mineral heterogeneity in patients with fragility fractures compared to those without fractures Dennis S Meredith, Eve Donnelly, Brandon Hirsch, Joseph Nguyen, Joseph M Lane, Adele L Boskey Poster No. 1534 Site-specific Quantification of Bone Mechanical Properties using Highly Nonlinear Solitary Waves Sean L Borkowski, Sophia N Sangiorgio, J. K Yang, Claudio Silvestro, Luigi De Nardo, Chiara Daraio, Edward Ebramzadeh Poster No. 1535 Altered Bone Cell Mechanosensitivity Can Explain the Substantially Increased Bone Mass in Hypoparathyroidism Patrik Christen, Bert V Rietbergen, Ralph Müller, Mishaela R Rubin, David W Dempster, John P Bilezikian, Keita Ito Poster No. 1536 Identification of TGFβ Signaling Pathway Genes Expression in Peripheral Blood and Bone Segments of Osteoporotic Postmenopausal Women Theodora Koromila, Zoe Dailiana, Stavroula Samara, Chris Chassanidis, Panagiotis Georgoulias, Vassiliki Aleporou-Marinou, Panagoula Kollia Poster No. 1537 Cross-Sectional Properties of the Tibial Diaphysis in Ambulatory Children with Myelomeningocele Tishya A Wren, Nicole M Mueske, Vicente Gilsanz, Linda S Chan, Deirdre D Ryan Poster No. 1538 Osteoblast Cultures from the Stapes of Patients with Otosclerosis Demonstrate Hypermineralization, which is Corrected by Alendronate Gloria Gronowicz, Yvonne Richardson, John Flynn, Gerald Leonard, Kourosh Parham Poster No. 1540 Effects of the Inter-Individual Variation in Femoral Neck Width on Age-Related Bone Loss and Strength Yan Epelboym, N. Remi Gendron, Jillian Mayer, Joseph Fusco, Philip Nasser, Gary Gross, Richard Ghillani, Karl J Jepsen Poster No. 1541 Is Bone Quality Altered with Alendronate Treatment in Osteoporotic Patients? David Pienkowski, Daniel Porter, Marie-Claude Monier-Faugere, Hartmut Malluche Poster No. 1542 Treatment of spontaneous osteonecrosis of the knee (SPONK) by a bisphosphonate; a pilot series in 17 patients Jan Juréus, Anders Lindstrand, Mats Geijer, David Roberts, Magnus Tägil Poster No. 1543 A Modified Sagittal Spine Postural Classification and its Relationship to Deformities and Spinal Mobility in a Chinese Postmenopausal Osteoporotic Population H. Wang, H. Giambini, W. Zhang, C. Zhao, K. An, Y. Li, W. Lan, J. Li, X. Jiang, Chao Chen PS2 Progenitors and Stem Cells Poster No. 1544 Property of Mesenchymal Stem Cells in Oral Tissues Koji Otabe, Ichiro Sekiya, Nobuyuki Kawashima, Kunikazu Tuji, Takeshi Muneta Poster No. 1545 Identification of unique mesenchymal stem cell populations from mouse bone marrow using multicolor FACS Eric Veien, Jie Song Poster No. 1546 Efficient Differentiation and Characterization of Murine Induced Pluripotent Stem Cell-Derived Osteoprogenitor Cells without Embryoid Body Formation Yoshihiro Dogaki, Sang Yang Lee, Takahiro Niikura, Akihiro Koh, Takaaki Koga, Etsuko Okumachi, Kenichiro Kakutani, Hiroaki Hirata, Kotaro Nishida, Ryosuke Kuroda, Masahiro Kurosaka Poster No. 1547 Induction of induced pluripotent stem cells (iPSC) to Multipotent mesenchymal stem cells and in vivo bone formation Feng Li, Christopher Niyibizi Poster No. 1548 Genetic Background affects Induced Pluripotent Stem (iPS) Cell Generation Lauren Schnabel, Christopher Abratte, John Schimenti, Lisa Fortier Poster No. 1549 The Use of Bone Marrow Supernatant in 2D and 3D Mesenchymal Stem Cell Culture Fergus N Bostock, Gordon W Blunn, Melanie Coathup Poster No. 1550 Evaluation of Platelet-rich Plasma on Stem Cell Proliferation and Migration Lin Song, Marc Long, Sue Coyle, Jeffrey Spalazzi, Twana Davisson Posters Poster No. 1539 Three-Year Follow-up on Changes in Bone Micro-architecture and Bone Strength at the Distal Radius Ingrid Knippels, L. Joseph Melton, Shreyasee Amin, Sundeep Khosla, Harry van Lenthe Poster No. 1551 Safety and Complications Reporting Update on the Re-Implantation of Culture-Expanded Mesenchymal Stem Cells Using Autologous Platelet Lysate Technique Stephen Faulkner, Christopher J Centeno, John R Schultz, Michael Freeman, Brent Robinson, Ron Hanson Poster No. 1552 Enhanced chondrogenic potential of induced pluripotent stem cells derived from human articular cartilage Rosa M Guzzo, Ren-He Xu, Hicham Drissi Poster No. 1553 Comparative Chondrogenic Capacities of Equine Mesenchymal Stem Cells Derived from Synovium, Bone Marrow and Adipose Tissue Yu-Wen Chen, Allison Stewart, Matthew Stewart Poster No. 1554 Human MSCs exert anti-inflammatory effect in cartilage and synovium explants Lin Song, Renwen Zhang, Carlos Aponte, Sue Coyle, Twana Davisson Poster No. 1555 Human mesenchymal stem cells in synovial fluid increase in the knee with osteoarthritis Miyoko Ojima, Ichiro Sekiya, Mika Yamaga, Hideyuki Koga, Masafumi Horie, Kunikazu Tsuji, Takeshi Muneta Poster No. 1556 Origin of Anomalous Gene Expression in Mesenchymal Stem Cells from Osteoarthritic Patients Abdulaziz M Almaawi, Hong Tian Wang, John Antoniou, Fackson Mwale Poster No. 1557 Prevention of Post-Traumatic Arthritis by Mesenchymal Stem Cell Therapy Brian O Diekman, Chia-Lung Wu, Craig R Louer, Bridgette D Furman, Steven A Olson, Farshid Guilak Poster No. 1558 Distribution and homing of stem cells after intra-articular injection to normal and arthritic joints Ashlee E Watts, Alan Nixon Poster No. 1559 Human Mesenchymal Stem Cells Generate a Distinct Pericellular Zone of MMP Activities via Binding of MMPs and Secretion of High Levels of TIMPs Thomas Lozito, Wesley Jackson, Peter Alexander, Leon Nesti, Rocky Tuan 131 Posters Poster No. 1560 In Vitro Expansion Rates and Multi-Potentiality of Canine Adult Intraarticular Adipose, Synovium, and Ligament Multipotent Stromal Cells Mandi Lopez, Nan Zhang, Jeffrey Gimble Poster No. 1561 Analysis of Gene-Specific DNA Methylation Patterns in Cells Derived from Equine Adult and Fetal Tissues Lisa Fortier, Catherine Hackett, Line Greve, Kira Novakofski Poster No. 1562 Low-Power Laser Irradiation Inhibits LPS-Induced Inflammation of Human Adipose Derived Stem Cells Jyun-Yi Wu, Yan-Hsiung Wang, Chia-Hsin Chen, Ming-Long Yeh Poster No. 1563 Tendon-Bone Healing in a Rat Cannulation Model David M Levy, Comron Saifi, Jennifer L Perri, Sue Coyle, Carlos Aponte, Renwen Zhang, Thomas R Gardner, Christopher S Ahmad Poster No. 1564 Hypoxia Mediated Efficient Expansion of Human Tendon-Derived Stem Cells (hTDSCs) in vitro Pauline Po Yee Lui, Yuk Wai Lee, Yun Feng Rui Poster No. 1565 Tendons of CITED2-haploinsufficient (+/-) mice exhibit deficiencies seen in aging: Diminished stem cell self-renewal and impaired wound healing Zhiyong He, Takuya Ruike, Daniel Leong, Zhengzhe Li, Damien Laudier, Mitchell B Schaffler, Robert J Majeska, Yu-Chung Yang, Evan L Flatow, Herb B Sun Poster No. 1566 Genetically Engineered Adipose-derived Stem Cells for Therapeutic Angiogenesis Using Biodegradable Nanoparticles Lorenzo R Deveza, Jerry Lee, Jeffrey Choi, Galym Imanbayev, John Cooke, Fan Yang Poster No. 1572 Purified Human Perivascular Stem Cells Induce More Bone Formation in Comparison with Unsorted Adipose Stromal Cells in Response to rhBMP2 Raghav Goyal, Aaron W James, Janette Zara, Michael Chiang, Wei Yuan, Asal Askarinam, Shen Pang, Mirko Corselli, David Stoker, Xinli Zhang, Bruno Peault, Kang Ting, Chia Soo Poster No. 1573 Synergism between VEGF and BMP-6 signaling enhances Collagen I and Osterix gene expression in hADSCs Vedavathi Madhu, Yi Zang, Abhijit S Dighe, Ching Ju Li, Gary Balian, Quanjun Cui Poster No. 1574 Primary Cilia: Dynamic Chemosensors Controlling Adipose Stem Cell Osteogenesis Josephine C Bodle, Michelle E Phillips, Candace D Rubenstein, Jie Qi, Albert J Banes, Susan H Bernacki, Elizabeth G Loboa Poster No. 1575 Obesity Alters the Multilineage Potential of Bone Marrow-Derived Mesenchymal Stem Cells and Infrapatellar Fat Pad-Derived Stem Cells Chia-Lung Wu, Brian O Diekman, Farshid Guilak, Deeptee Jain Poster No. 1576 Genetic Variant on PLIN4 is Associated with Obesity Mai Abdel-Ghani, Todd Spock, Karin Kuhn, Eric Rupe, Clare E Griffis, Heather Gordish Dressman, Joseph Devaney, Eric Hoffman, Priscilla Clarkson, Laura Tosi Poster No. 1567 Assessing Survival of Delivered Cells in Bone Tissue Engineering Ashley Allen, Zulma Gazit, Susan Su, Hazel Stevens, Robert E Guldberg Poster No. 1577 Transplantation to Control Type 1 Diabetes in a Mouse Model by Stem Cell-Like Cells Derived from Human Skeletal Muscles Shing-Hwa Liu, Chen-Yuan Chiu, Yuan-Peng Yen, Rong-Sen Yang Poster No. 1568 Gene Delivery of BMP2, Noggin, and GNAS to a Human Osteoblast Cell Line Induces Apoptosis in a Dose-Dependent Manner Shaheen Jeeawoody, Anusuya Ramasubramanian, Fan Yang Poster No. 1578 A Red-nucleus Retro-vector for Rat Muscle-derived Stem Cell Modification Ying Tang, Hongshuai Li, Kara Imbrogno, Zeyu Xiao, Freddie H Fu, Johnny Huard, Bing Wang Poster No. 1569 Adipose-Derived Purified PSCs Heal Critical-Size Mouse Calvarial Defects Asal Askarinam, Janette Zara, Aaron W James, Wei Yuan, Michael Chiang, Alan Nguyen, David Stoker, Shen Pang, Mirko Corselli, Xinli Zhang, Bruno Peault, Kang Ting, Chia Soo Poster No. 1579 Recreating the Traumatized Muscle Microenvironment: Effects of TGB1 and Topography in Progenitor Cell Culture Gregory T Christopherson, Emily H Shin, Leon J Nesti, Wesley Jackson, Youngmi Ji Poster No. 1570 Periosteum Regenerates on Periosteum-Denuded, Transported Bone Segment Favia Merritt, Abigail Erinc, Melissa L Knothe Tate 132 Poster No. 1571 Bone Forming Peptide 1 (BFP1), Derived from Full BMP-7 Protein, Enhances Bone and Blood Vessel Formation via Smad and ERK Signal Proteins Hyung Keun Kim, Ji Hyun Kim, Dae Sung Park, Taek Rim Yoon Poster No. 1580 BMP-4 Promotes Fibro-Regulatory Gene Expression Following Traumatic Muscle Injury Matther Kluk, Wesley Jackson, Emily H Shin, Youngmi Ji, Leon J Nesti Poster No. 1581 Development of Injectable Octacalcium Phosphate-Hyarulonan Complex as a bone substitute material Kentaro Suzuki, Yoshitomo Honda, Takahisa Anada, Koshi N Kishimoto, Naohisa Miyatake, Masami Hosaka, Hideki Imaizumi, Eiji Itoi, Osamu Suzuki Poster No. 1582 WITHDRAWN Poster No. 1583 Enhanced effects of electrical polarization to form new bone on hydroxyapatite micro-granules and availability of platelet-rich plasma as a carrier Soichiro Itoh, Seiko Ohba, Wei Wang, Kimihiro Yamashita Poster No. 1584 Sulfated and HA-mineralized electrospun fibrous meshes for use as tissue engineering scaffolds Tera Filion, Artem Kutikov, Jie Song Poster No. 1585 Effects of bisphosphonate on osteoconductivity after implantation of beta tricalcium phosphate in rat adjuvant induced arthritis Takahiro Netsu, Naoki Kondo, Katsumitsu Arai, Akira Ogose, Naoto Endo Poster No. 1586 Biomechanical and Histological Evaluation of an Injectable Calcium Phosphate Based Biomaterial Brian M Schlossberg, William R Walsh, Edward S Ahn, Nick Hancock, Andrew Spalding, Gladys Chan, Anthony Jacobson Poster No. 1587 New Porous bioceramic material formed via thermo-responsive hydrogel template Yin-Chih Fu, Chih-Kuang Wang, Je-Ken Chang, Chung-Hwan Chen, GwoJaw Wang, Mei-Ling Ho Poster No. 1588 Quantitative MicroCT Analysis of a Calcium Polyphosphate Gradient Scaffold Basma M Khoury, David Markel, Wei Song, Paul Skelton, Aliya Jawad, Weiping Ren Poster No. 1589 Enhanced Mechanical Properties, Osteogenesis and Bone Healing of Collagen Nanohydroxyapatite Scaffolds Occurs in a Nanohydroxyapatite Dependent Manner: An In Vitro and In Vivo Study Caroline M Curtin, Gráinne Cunniffe, Emmet Thompson, Glenn Dickson, Fergal J O’Brien Poster No. 1590 Micropatterning Bone Formation Using Mother of Pearl Ronke M Olabisi, Maude L Rowland, Christy L Franco, Joseph C Hoffmann, Jennifer L West Poster No. 1591 Biomimetic HA enhances the biological fluid uptake of 3-Dimensional Porous Metal Coatings Joseph Zitelli, Elizabeth Novak, Kevor TenHuisen Poster No. 1592 An Osteogenic and Angiogenic Collagen GlycosaminoglycanBioactive Glass Scaffold for Bone Tissue Engineering Elaine Quinlan, Sonia Partap, John Gibbons, Maria M Azevedo, Molly M Stevens, Fergal O’Brien Poster No. 1593 Development of Scaffolds with Tethered Epidermal Growth Factor to Improve Performance of Human Adult Stem and Progenitor Cells for Orthopaedic Tissue Engineering Vivek P Raut, Luis A Alvarez, Jaime Rivera, Linda Stockdale, Cynthia Boehm, Thomas Patterson, Linda Griffith, George F Muschler Posters PS2 Biomaterials - Bioactive Poster No. 1594 Effects of proliferation and differentiation of mesenchymal stem cells on the mechanical characteristic of collagen/β-TCP composite scaffold Takaaki Arahira, Mitsugu Todo Poster No. 1595 Generation of Cartilage and Bone Tissue Constructs via ScaffoldMediated Gene Delivery to MSCs Jonathan M Brunger, Franklin T Moutos, Pablo Perez-Pinera, Donald P Lennon, Arnold I Caplan, Charles A Gersbach, Farshid Guilak Poster No. 1596 100 mol % Substitution of Strontium into Bioglass® Enhances Human Mesenchymal Stem Cell Differentiation in vitro Pelin L Candarlioglu, Eileen Gentleman, Molly M Stevens Poster No. 1597 “Clickable” Cytocompatible PEG-co-polycarbonate Hydrogels for Encapsulation of Bone Marrow Stromal Cells Jianwen Xu, Fioleda Prifti, Jie Song Poster No. 1598 Induced Osteogenic Differentiation of Human Mesenchymal Stem Cells By Polyester Nanofiber Scaffolds In Combination With Melatonin Aja Aravamudhan, Meng Deng, Udaya Toti, Daisy Ramos, Matthew Harmon, Cato T Laurencin, Sangamesh Kumbar Poster No. 1599 The effect of pore size on the chondrogenesis of the adipose stem cells seeded in PCL scaffold using a pore size gradient: an in vitro and in vivo investigation Ji-Yun Ko, You-Jeong Choi, Jai-Sun Lee, Jin-Ho Lee, Gun-Il Im Poster No. 1600 Analysis of Spatial Regeneration of Tissue Following Treatment with Artificial Periosteum Shannon R Moore, Ulf Knothe, Stefan Milz, Melissa L Knothe Tate Poster No. 1601 Junctional Adhesion Markers of Periosteum Cells as a Basis for Functionalization of Solid Supported Lipid Bilayers Sarah F Evans, Anja Bernecker, Denitsa Docheva, Ralf P Richter, Melissa L Knothe Tate 133 Posters Poster No. 1602 Exposure-related effects of nano-silver to peripheral blood mononuclear cells: cellular uptake and biological responses Christina Greulich, Jörg Diendorf, Matthias Epple, Thomas A Schildhauer, Manfred Köller Poster No. 1612 Temporal Control of the Glass Transition Temperature and the Mechanical Properties of Biodegradable Polymer Networks for LoadBearing Soft-Tissue Scaffolds David L Safranski, Daiana Weiss, J. B Clark, W. R Taylor, Ken Gall Poster No. 1603 Selective Fibronectin Chemistry Mediates Contractility and Modulates Expression of Focal Adhesion Elements to Enhance Osteogenic Differentiation of Bone Marrow Stromal Cells Ram Sharma, Guido Bartalena, Jess G Snedeker Poster No. 1613 The Effect of Hydrothermal Treatment on the Biocompatibility of Biodegradable Magnesium Alloy Da-Jun Lin, Wan-Ching Chou, Shih-Ping Yang, Ming-Long Yeh, Tzer-Min Lee Poster No. 1604 Fabrication and Evaluation of a Novel Scaffold System with HighDensity Cell Seeding for Bone Regeneration: An Investigation of Cell Density Enhanced Osteogenic Expression John Igwe, Syam Nukavarapu Poster No. 1614 Investigating the Usefulness of the Small Punch Test in Retrieval Analysis Steven D Reinitz, Katherine J Franklin, Laura T Gray, Heather L Kluk, John H Currier, Douglas W Van Citters Poster No. 1605 In vivo study of enhanced bioactivity of titanium alloy by plasma surface modification Sze-Man Wong, Shuilin Wu, Paul K Chu, Kevin H K Yip, Kenneth M C Cheung, Keith D K Luk, Wai-Pan Yau, Guan-Ming Kuang, Kelvin W K Yeung Poster No. 1615 Injectable Microspheres for Localized Cytokine Delivery and Tracking Travelle Franklin-Ford, William L Murphy Poster No. 1606 The Effect of Adherens Junction Components on Keratinocyte Adhesion In Vitro: Potential Implications for Sealing the Skin-Implant Interface of ITAP Catherine Pendegrass, Bethan Tucker, Shelain Patel, David Garrod, Gordon Blunn Poster No. 1607 Exogenous BMP2 Increases Pro-Inflammatory Cytokine Production by Osteoblasts on Microtextured Titanium through TAB/TAK Pathway Sharon L Hyzy, Rene Olivares-Navarrete, Christian Tan, Barbara D Boyan, Zvi Schwartz Poster No. 1608 Nanofibrous microspheres promote osteogenic differentiation of rat bone marrow stem cells and bone regeneration Xiaobing Jin, Xiaohua Liu, Jing Wang, Jeremy M Holzwarth, Peter X Ma Poster No. 1609 Effects of Low Temperature Hydrogen Peroxide Gas Plasma Sterilization on In Vitro Cytotoxicity of Poly-ε-Caprolactone (PCL) Samuel Franklin, Ferris M Pfeiffer, Mary K Cockrell, Aaron M Stoker, Sonny Bal, James L Cook Poster No. 1610 Characterization of a Novel Porous Titanium Scaffold for Orthopedic Applications Janet Krevolin, James J Liu, Amy M Silverstein Poster No. 1611 Porous titanium as treatment for large segmental bone defects Johan Van der Stok, Mirthe de Haas, Olav P van der Jagt, Esther van Lieshout, Peter Patka, Jan Verhaar, Harrie Weinans 134 Poster No. 1616 Carrier Properties Similar to Subchondral Bone Enhance the Mechanical Cartilage Properties of Tissue-Engineered Osteochondral Constructs Elisa Hoenig, Uta Leicht, Thomas Winkler, Gabriela Mielke, Fabian Peters, Micheal M Morlock, Arndt F Schilling Poster No. 1617 Engineering an osteochondral composite for the Total Joint Resurfacing Hisashi Mera, James E Dennis Poster No. 1618 Characterization of a Novel Non-Degradable PVA/Chitosan Scaffold Cross-linked with Genepin to Protein-Loaded Alginate/Chitosan Microparticles for Articular Cartilage Repair Neel Patel, Tony Chen, Florian Wanivenhaus, Suzanne A Maher Poster No. 1619 Type I Collage-Alginate Composite Hydrogel Promotes Chondrogenesis of Murine Adipose-Derived Stromal Cells Diane R Wagner, Yongxing Liu Poster No. 1620 WITHDRAWN Poster No. 1621 Sulfated and Sulfonated PEGDMA Hydrogels for the Encapsulation and Chondrogenic Differentiation of Rabbit Bone Marrow Stromal Cells Jeffrey Lange, Pingsheng Liu, Henry Huang, David Ayers, Jie Song Poster No. 1622 Microgel-based Delivery of Soluble Factors for Articular Cartilage Engineering Sathish Ponnurangam, Grace D O’Connell, Ponisseril Somasundaran, Clark T Hung Poster No. 1624 Subchondral Pre-solidified Chitosan-Blood Implants Degrade In Situ and Elicit PMNs, Osteoclasts, Subchondral Plate Remodeling, and Delayed Chondroinduction at 3 weeks in a Rabbit Model of Marrow Stimulation Charles-Hubert Lafantaisie Favreau, Jessica Guzmàn-Morales, Jun Sun, Gaoping Chen, Adam Harris, Duncan Smith, Alberto Carli, Janet E Henderson, William D Stanish, Caroline D Hoemann Poster No. 1625 Cell-type Specific Migration Response to Substrate Thickness/ Stiffness Gradient Shou-Chien Shen, Wei-Ren Chang, Pen-hsiu Grace Chao Poster No. 1626 Enhancing Osteogenic Differentiation of Mouse Induced Pluripotent Stem Cells (iPSC) in vitro by Nanofiber Matrices Feng Li, Justin L Brown, Christopher Niyibizi Poster No. 1627 In vivo Osteogenic Differentiation of Adipose and Bone Marrow Derived Stem Cells in a Functionalized Hydrogel Christopher R Dosier, Ted T Lee, Edward A Phelps, Andres J Garcia, Robert E Guldberg Poster No. 1628 Engineering Upscaled Endochondral Bone with Human Adult Mesenchymal Stromal Cells Celeste Scotti, Beatrice Tonnarelli, Adam Papadimitropoulos, Francine Wolf, Stefan Schaeren, Ivan Martin, Andrea Barbero Poster No. 1629 Enhanced Cellular Responses of Human Bone Marrow Stromal Cells Cultured on Pre-treated Surface with Allogenic Platelet-rich Plasma Seung Han Shin, Jeong Joon Yoo, Ha Na Kim, Jin Woo Nam, Hee Joong Kim Poster No. 1630 Bioactive Polysaccharide Bone Grafts: In Vitro Evaluation Using Human Mesnchymal Stem Cells (hMSCs) Aja Aravamudhan, Daisy Ramos, Reuben Mathew, Matthew Harmon, Udaya Toti, Meng Deng, Cato T Laurencin, Sangamesh Kumbar PS2 Tissue Engineering - Soft Tissue Poster No. 1631 Mechanically Induced Stem Cell Alignment Throughout a 3D Collagen Matrix for Anisotropic Engineered Tissue Matthew T Harris, Kristopher M Ragger, Rohan Thakkar, Eda D Yildirim Poster No. 1632 High concentration of PRP enhanced growth of synovial fluid mesenchymal stem cells in alginate beads Chih-Hwa Chen, Shu Wen Whu, Kun-Chung Wang, Chun-I Su, Hsien-Tao Liu, Chung-Ming Yu, Chak-Bor Wong, I-Chun Wang, Hsia-Wei Liu, Shi-Hui Chen, Ching-Lin Tsai Posters Poster No. 1623 Development of Novel Chondroprotective Matrilin-3 Hybrid Nanotubes that Enhance Chondrocyte Adhesion, Increase Matrix Synthesis, and Reduce Catabolic Gene Expression Yupeng Chen, Kevin Koopman, Chathuraka Jayasuriya, Jack Cossman, Thomas Webster, Hicham Fenniri, Qian Chen Poster No. 1633 In Vitro Tissue Generation by Adult Equine Multipotent Stromal Cells on Collagen Scaffolds Mandi J Lopez, Lin Xie, Jeffrey Gimble, Gordana Vunjak-Novakovic, Anna Marsano, Yanru Zhang Poster No. 1634 A Dual Delivery Vector Gene-activated Matrix Enables Multiple Gene Delivery for Enhanced Bone Tissue Regeneration Caroline M Curtin, Erica G Tierney, Sally Ann Cryan, Garry P Duffy, Fergal J O’Brien Poster No. 1635 Effects of Deferoxamine Preconditioning on Vascular Endothelial Growth Factor Expression and Osteogenic Differentiation of Human Mesenchymal Stem Cells Tamim Diab, Hazel Stevens, Robert E Guldberg Poster No. 1636 Comparative Evaluation of in vitro Osteogenic Differentiation of Adult and Fetal Mesenchymal Stem Cells on Three-Dimensional HA/β-TCP Scaffolds Chris H Jo, Hyang. Kim, Qiu Yu Jiang, Ji Eun Kim, Young Gil Lee, Pil Hwan Yoon, Kang Sup Yoon Poster No. 1637 Human disc cells and mesenchymal stem cells differentiation in a thermoreversible hydrogel: an in vitro and ex-vivo study Britta Striegl, Sibylle Grad, David Eglin, Lorin M Benneker, Epifania Bono, Mauro Alini, Ursula Graf-Hausner, Marianna Peroglio Poster No. 1638 WITHDRAWN Poster No. 1639 A comparison of the functionality and in vivo phenotypic stability of cartilaginous tissues engineered from different stem cells sources Tatiana Vinardell, Eamon J Sheehy, Conor T Buckley, Daniel J Kelly Poster No. 1640 Fate of hMSC in tissue engineered constructs in vivo Delphine Logeart-Avramoglou, Adeline Cambon-Binder, Pierre Becquart, Marianne Bourguignon, Laurent-Emmanuel Monfoulet, Morad Bensidhoum, Hervé Petite Poster No. 1641 Articular Chondrocyte Differentiation from Human Mesenchymal Stem Cells through the Sequential Administration of Growth Factors Andrew M Handorf, Wan-Ju Li Poster No. 1642 The Influence of BMP-13 on Chondroinduction of Human Bone Marrow Mesenchymal Stem Cells Hilary Zelenka, Steven Elder 135 Posters Poster No. 1643 Osteoprotegerin (OPG) Preconditions Human Mesenchymal Stem Cells for Enhanced Osteogenic Differentiation SunMi Palumbo, Matthew W Squire, Wan-Ju Li Poster No. 1644 Response of Human Mesenchymal Stem Cells Regulated by Demineralized Bone Matrix Zachary Pflum, SunMi Palumbo, M. W Squire, R. S Tuan, Wan-Ju Li Poster No. 1645 Performance of E.coli expressed rhBMP-2 on rabbit ulna segmental defect repair Hiroyuki Irie, Masahiro Nagaya, Kazushige Sugama, Hiroaki Nakamura, Kunio Takaoka Poster No. 1646 Sequential Delivery of Growth Factors Stimulates Tendon Cell Metabolism Brian Kincaid, Rachel Greenberg, Lewis Lane, Pasquale Razzano, Daniel A Grande Poster No. 1647 Distribution of Platelet Concentration in Whole Blood and PlateletRich Plasma William S Johnson, Theerawit Hongnaparak, Joan E Bechtold, Dean T Tsukayama Poster No. 1648 Heparan Sulfate is Retained in Peptide Hydrogel Scaffold via Ionic Interactions: Potential for Delivery of HB-IGF-1 Emily Florine, Rachel Miller, Richard T Lee, Parth Patwan, Alan J Grodzinsky Poster No. 1649 Small Molecule Cyclic Adenosine Monophosphate Analogues for Bone Regenerative Engineering Kevin W Lo, Ho Man Kan, Cato T Laurencin Poster No. 1650 Effect of platelet-rich plasma injection on systemic concentrations of performance-enhancing growth factors Amy Wasterlain, Hillary J Braun, HyeonJoo Kim, Jason Dragoo Poster No. 1651 BMP-7 Enhances hMSC Chondrogenesis and Osteogenesis in an Osteochondral Plug John G Barber, Matthew Squire, Wan-Ju Li Poster No. 1652 Effects of Riboflavin Crosslinking on Tissue Engineered Intervertebral Discs Development in vivo Robert I Mozia, Andrew R James, Matthew Koff, Sarah Pownder, Hollis G Potter, Roger Hartl, Lawrence Bonassar Poster No. 1653 Bone Marrow Derived Mesenchymal Stem Cell Cell-Sheets and Silk Scaffolds For Inner Annulus Fibrosus Regeneration Eugene See, Siew Lok Toh, James C Goh 136 Poster No. 1654 Macromer Concentration Influences the Differentiation of Human MSCs Towards a Nucleus Pulposus-like Phenotype in Photocrosslinked Carboxymethylcellulose Hydrogels Michelle S Gupta, Steven Nicoll Poster No. 1655 Biaxial Mechanics and Inter-lamellar Shearing of Electrospun Bilayers for Annulus Fibrosus Tissue Engineering Tristan P Driscoll, Ryan H Nakasone, Spencer E Szczesny, Dawn M Elliott, Robert L Mauck Poster No. 1656 Effects of Cyclic Dynamic Loading on Tissue Engineered Intervertebral Discs Robert I Mozia, Lawrence Bonassar Poster No. 1657 Repair of Defects in the Rat Tail Annulus Fibrosus Using Injectable High Density Collagen Gels Brandon Borde, Andrew R James, Roger Härtl, Lawrence Bonassar Poster No. 1658 Engineered Decellularized Intervertebral Disc ECM Gels for Nucleus Pulposus Repair Philippe Abdel-Sayed, Patrizia Spoerri, Alizée Grimm, Dominique P Pioletti Poster No. 1659 Tendon-Derived Matrix Coated Multi-Layered Electrospun Scaffolds for Tendon Tissue Engineering Kirk J Hippensteel, Abby Chainani, Alysha Kishan, N. W Garrigues, David S Ruch, Farshid Guilak, Dianne Little Poster No. 1660 Bulk Mineralization Stiffens Collagen Scaffolds Lester Smith, John Boyle, Zhen Li, Jill D Pasteris, Guy Genin, Stavros Thomopoulos Poster No. 1661 Evaluation of Tissue Engineering Repairs for Achilles Tendon Rupture in Rat Model Ming-Long Yeh, Meng-Yi Chen, Ping-Chia Lin, Wen-Ling Chen Poster No. 1662 Engineered Tendon Matrix Promotes the Formation of Tendon-Like Tissues In Vivo Jianying Zhang, James H Wang Poster No. 1663 Controlled Delivery of Mesenchymal Stem Cells and Growth Factors Using a Tendon-Specific Nanofiber Scaffold Cionne C Manning, W. Liu, Andrea G Schwartz, Jingwei Xie, Shelly Sakiyama-Elbert, Matthew J Silva, David Amiel, Younan Xia, Stavros Thomopoulos, Richard H Gelberman Poster No. 1665 A Novel Electrospun Polydioxanone Patch for the Biological Enhancement of Rotator Cuff Repairs Osnat Hakimi, Richard J Murphy, Urszula Stachewicz, Andrew J Carr Poster No. 1666 Novel Design of Organized Nanofibrous Scaffolds to Mimic the Macroscopic Curvature of Native Meniscus Matthew B Fisher, Elizabeth Henning, Robert L Mauck Poster No. 1667 Effect of Dynamic Culture on the Proliferation of Bone Marrow Stromal Cells Seeded in Polyurethane Meniscus Scaffolds Chaoxu Liu, Roland Meister, Carl Haasper, Christian Krettek, Henning Windhagen, Gabriela von Lewinski, Michael Jagodzinski PS2 Cartilage/Meniscus/ Synovium - Gene Therapy Poster No. 1668 Localization and Doxycycline Control of In Vivo Transgene Expression in Injured Joints Hannah H Lee, Michael J O’Malley, Karin A Payne, Nicole A Friel, Xiao Xiao, Constance R Chu Poster No. 1669 Ex-vivo gene therapy-induced cartilage regeneration: comparison of different subpopulations of primary muscle-derived cells Hongshuai Li, Minakshi Poddar, Arvydas Usas, Johnny Huard Poster No. 1670 SOX trio-co-transduced Adipose Stem Cells Enhance Cartilage Repair and Delay the Progression of Osteoarthritis in the Rat Jong Min Lee, Kyung-Il Kim, Jung Min Ahn, Gun-Il Im Poster No. 1671 Transduction of siRNA Targeting TNF-a to Rat Knee Joint via Sonoporation Hiroaki Inoue, Yuji Arai, Ryu Terauchi, Masazumi Saito, Shinji Tsuchida, Osam Mazda, Toshikazu Kubo Poster No. 1672 Delivery of siRNA and protein to articular chondrocytes by the TAT protein transduction domain Ron June, Akiko Eguchi, Diana C Brinson, Martin K Lotz, Steven F Dowdy Poster No. 1673 A Novel Ionizable Cationic Lipid Nanoparticle - based Delivery System for Potential RNAi Therapy in Age-related Cartilage Degeneration Heng Wu, Zhijun Yang, Doris, W.T. Au, Baosheng Guo, Zihong Lin, Zhong Liu, Fangyuan Wei, Gang Li, Weimin Liao, Ling Qin, Leungkim Hung, Lei Wei, Ge Zhang Poster No. 1674 A dual expression long hairpin for IL-1 beta and TNF-alpha knockdown in chondrocytes improves aggrecan and collagen type IIb expression Alan Nixon, Michael Scimeca Poster No. 1675 Arthroscopic Implantation of Autologous Chondrocytes Transduced with rAAV5-IGF-I Improves Articular Cartilage Repair at 8 Weeks Kyla Ortved, Laila Begum, Alan Nixon Posters Poster No. 1664 Fiber-Aligned Polymer Scaffolds for Rotator Cuff Repair in a Rat Model David P Beason, Brianne K Connizzo, LeAnn M Dourte, Lena Edelstein, Jennica J Tucker, Stephen S Liu, Robert L Mauck, Louis J Soslowsky, David R Steinberg, Joseph Bernstein Poster No. 1676 Remodelling of Human Osteoarthritic Articular Cartilage in Situ Over Time by rAAV-Mediated Overexpression of TGF-β Magali Cucchiarini, Gertrud Schmitt, Myriam Ekici, Anna Wezel, Dieter Kohn, Henning Madry Poster No. 1677 WITHDRAWN PS2 Cartilage/Meniscus/Synovium Cartilage & Matrix Proteins Poster No. 1678 Superficial zone chondrocytes from bovine articular cartilage respond predominately to HA oligosaccharides Nobunori Takahashi, Wataru Ariyoshi, Cheryl B Knudson, Warren Knudson Poster No. 1679 Heparan Sulfate-Dependent Mechanisms of Pathological Skeletogenesis Julianne Huegel, Christina Mundy, Eiki Koyama, Maurizio Pacifici Poster No. 1680 Modulation of SZP Synthesis in Superficial Zone Articular Chondrocytes by Wnt Signaling Takashi Iwakura, Atsuyuki Inui, A. Hari Reddi Poster No. 1681 Lubricin Expression is Suppressed by Hypoxia through HIF-1 Mediated Pathway Taku Hatta, Koshi N Kishimoto, Hiroshi Okuno, Akira Sekiguchi, Yoshiaki Itoigawa, Eiji Itoi Poster No. 1682 Molecular Weight Characterization of PRG4 Species using MultiAngle Laser Light Scattering (MALLS) Bridgett L Steele, Tannin A Schmidt Poster No. 1683 Muscular loading of joints and its effect on synovial fluid composition Ziad Abusara, Bridgett L Steele, Tannin A Schmidt, Walter Herzog Poster No. 1684 CD44 knock-down in bovine chondrocytes results in increased release of bound HYAL2 Daisuke Hida, Cheryl B Knudson, Emily B Askew, Yohei Ohno, Warren Knudson 137 Posters Poster No. 1685 Comparison of Depth-dependent Characteristics of Equine and Human Articular Cartilage from the Knee Joint Kim Benders, Jos Malda, Travis Klein, Janny De Grauw, Marja Kik, Dietmar Hutmacher, Daniel Saris, Rene Van Weeren, Wouter Dhert PS2 Cartilage/Meniscus/ Synovium - Immune-Mediated Arthritis Poster No. 1686 The effects of interleuikin-32 alpha on development of inflammatory arthritis and endotoxin shock in mice Masanori Nakayama, Yasuo Niki, Toshiki Kawasaki, Hiroya Kanagawa, Yuuki Takeda, Eri Katsuyama, Hiroyasu Ikegami, Yoshiaki Toyama, Takeshi Miyamoto Poster No. 1687 A crucial role for lectin-like oxidized LDL receptor-1 signal on cartilage destruction in inflammatory arthritis Ishikawa Masahiro, Ito Hiromu, Yoshitmi Hiroyuki, Akiyoshi Miki, Tanida Shimei, Murata Kouichi, Kume Noriaki, Sawamura Tatuya Poster No. 1688 IL-27-producing CD14+ cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration Shimei Tanida, Hiromu Ito, Masahiro Ishikawa Poster No. 1689 Silencing the Expression of Connexin 43 Decreases Inflammation in Rat Synovium Shinji Tsuchida, Yuji Arai, Ryu Terauchi, Kuniaki Honjo, Shuji Nakagawa, Hiroaki Inoue, Ryo Oda, Daisaku Tokunaga, Osam Mazda, Toshikazu Kubo Poster No. 1695 Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on TLR4 Rik Schelbergen, Arjen Blom, Martijn H van den Bosch, Annet Sloetjes, Wim Schreurs, Thomas Vogl, Johannes Roth, Wim van den Berg, Peter van Lent Poster No. 1696 The effects of S100A12 protein for OA chondrocytes Motoshige Nakashima, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Takaaki Ohmachi, Yohei Ohno, Shinya Ishiduka, Tetsuya Matsukawa, Tomoyuki Oda, Akira Takamatsu, Satoshi Yamashita, Naoki Ishiguro Poster No. 1697 The Role of Connexin43 in Osteoarthritis Atum Buo, Corinne Niger, Danielle Cassagrande, Joseph P Stains Poster No. 1698 Co-culture of Meniscus and Cartilage Explants with Infrapatellar Fat Pad Tissue Stimulates Elevated Proteoglycan Release Monica Bendernagel, James Nishimuta, Marc E Levenston Poster No. 1699 Adipokines Elicit Dose-Dependent Catabolic Responses in Cartilage and Meniscus Tissues James Nishimuta, Monica Bendernagel, Marc E Levenston Poster No. 1690 Decresed Semaphorin3A expression correlates with disease activity of Rheumatoid Arthritis S. Takagawa, Fumio Nakamura, Ken Kumagai, Yoji Nagashima, Yoshio Goshima, Tomoyuki Saito Poster No. 1700 Bovine lactoferricin induces TIMP-3 via the ERK1/2-Sp1 axis in human articular chondrocytes Dongyao Yan, Di Chen, Gabriella Cs-Szabo, Hee-jeong Sampen Poster No. 1691 Isoprostane Levels are Altered in Rheumatoid Arthritis and Suppress NFκB Activity to Inhibit Osteoclast Formation James Edwards, Seint T Lwin, Joshua Brooks, Lynett Danks, Karin Lundberg, Ginger Milne, Jason Morrow Poster No. 1701 The Inhibition of Bradykinins Results in Down Regulation of MMPs and IL-1β in Human OA Synovial Fibroblasts and Osteoarthritic Chondrocytes William Wu, Magdalena Pasierb Poster No. 1692 Radiological Analysis on Hands and Large joints in Systemic Juvenile Idiopathic Arthritis Treated with Tocilizumab, an Anti-IL6 Receptor Monoclonal Antibody Chie Aoki, Yutaka Inaba, Tomoyuki Imagawa, Takako Miyamae, Masaaki Mori, Tomoyuki Saito, Shumpei Yokota Poster No. 1702 Interleukin-1β-induced changes in osteoarthritic human chondrocytes are inhibited by HYMOVIS™, a hexadecylamide hyaluronan derivative (HYADD®4-G) Margaret M Smith, Amy Russell, Antonella Schiavinato, Christopher B Little PS2 Cartilage/Meniscus/Synovium Cartilage Matrix Degradation Poster No. 1703 A-2-Macroglobulin Inhibits Inflammatory Cytokines and MMPs in Osteoarthritis Lei Wei, Xiaochun Wei, Yuzhi Wei, Xiaowei Wang, Braden C Fleming, Richard Terek, Qian Chen, Ge Zhang Poster No. 1693 CD44 cleavage provides insight into the endogenous protease activity of chondrocytes in human cartilage Daisuke Hida, Cheryl B Knudson, Yohei Ohno, Nobunori Takahashi, Warren Knudson 138 Poster No. 1694 Bovine lactoferricin utilizes extracellular and intracellular mechanisms to regulate gene expression in human articular chondrocytes Dongyao Yan, Di Chen, Hee-jeong Sampen Poster No. 1704 Follistatin alleviates articular cartilage degradation induced by carrageenan Jun Yamada, Kazumasa Miyatake, Mika Yamaga, Ichirou Sekiya, Takeshi Muneta, Kunikazu Tuji PS2 Cartilage/Meniscus/ Synovium - Cytokines Poster No. 1706 Characterization of Role of the Plant-derived Polyphenol Resveratrol in Human Articular Cartilage and Chondrosarcoma Hee-Jeong Im, Xin Li, Jae-sung Kim, Di Chen, Dongyao Yan, Brian Cole, Andre J van Wijnen Poster No. 1707 The Chondroprotective Properties of Curcumin (Curcuma longa) and Curcumin Derived Polyenolic Zinc Binding Inhibitors against IL-1β and OsM-induced Chondrolysis Elena Katzap, Matthew Golstein, Neil V Shah, John Schwartz, Pasquale Razzano, Lorne Golub, Francis Johnson, Robert Greenwald, Daniel A Grande Poster No. 1708 The Metabolic Effect of Resveratrol on Juvenile and Osteoarthritic Chondrocytes Jason Dragoo, Hyeon Joo Kim, Hillary J Braun, Huy D Phan, Eun Seok Gil, David Kaplan Poster No. 1709 The Role of IL-6 in Osteoarthritis and Cartilage Regeneration Anika Tsuchida, Michiel Beekhuizen, Arjan Bot, Bernd Geurts, Joris Bekkers, Daniel Saris, Wouter Dhert, Laura Creemers Poster No. 1710 Connective tissue growth factor enhances IL-6 production in human synovial fibroblasts through αvβ5 integrin, apoptosis signalregulating kinase-1, p38 and JNK dependent pathways Hsuan-Chih Liu, Show-Mei Chuang, Chih-Hsin Tang Poster No. 1711 WISP-1 induces IL-6 production in human synovial fibroblasts through PI3K, AKT and NF-κB pathways Ju-Fang Liu, Chih-Hsin Tang, Sheng-Mou Hou, Chun-Han Hou Poster No. 1712 Inhibition of geranylgeranylation reduces MCP-1 production in IL-1βstimulated human synoviocytes Yukio Akasaki, Shuichi Matsuda, Shinya Kawahara, Yukihide Iwamoto Poster No. 1713 Synergistic Role of Oncostatin M and IL-1β in an Arthritic Induced Cell Culture Model System Liliana Mellor, Julie T Oxford, Cheryl L Jorcyk Poster No. 1714 IGF-1 Reduced Matrix Degradation and Enhanced Biosynthesis in IL-1α-Treated Injuriously Compressed Cartilage Yang Li, Paul Kopesky, Birgit Schoeberl, Alan J Grodzinsky PS2 Cartilage/Meniscus/ Synovium - Growth Factors & Aging Poster No. 1715 Activation of SMAD2/3 Pathway by Transforming Growth Factor beta down Regulates MMP13 Expression in Human End-stage Cartilage Explants Arjan van Caam, Esmeralda Blaney Davidson, Elly Vitters, Wim B van den Berg, Peter M van der Kraan Posters Poster No. 1705 Overexpression of cathepsin K in human osteoarthritic cartilage Eiji Kozawa, Yoshihiro Nishida, Xianwu Cheng, Hiroshi Urakawa, Naohisa Futamura, Yoshihisa Yamada, Shinji Kitamura, Koji Sato, Masafumi Kuzuya, Naoki Ishiguro Poster No. 1716 SnoN prevents BMP-induced hypertrophic conversion of chondrocytes Ichiro Kawamura, Yasuhiro Ishidou, Katsuyuki Imamura, Masahiro Yokouchi, Setsuro Komiya, Shingo Maeda Poster No. 1717 The involvement of endoplasmic reticulum stress in FGFR3-related chondrodysplasias Ryosuke Sato Poster No. 1718 FGF-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis and PKC delta pathway in articular chondrocytes Dongyao Yan, Michael B Ellman, Prasuna Muddasani, Gabriella CsSzabo, Hee-jeong Sampen Poster No. 1719 FGFR1 Is Responsible For FGF-2-Induced Catabolic Activities In Human Articular Chondrocytes Dongyao Yan, Michael B Ellman, Prasuna Muddasani, Di Chen, Heejeong Sampen Poster No. 1720 Common and Early Cartilage Degradation Patterns in Aging and Osteoarthritic Human Knees Chantal Pauli, Stuart Duffy, Akihiko Hasegawa, Shawn P Grogan, Martin K Lotz, Darryl D D’Lima Poster No. 1721 Degeneration of human femoral condyle articular cartilage involves changes in collagen network orientation and anisotropy Christopher B Raub, Ssu-Chieh Hsu, Iliya Goldberg, Emily K Schoenhoff, Michele M Temple-Wong, Albert Chen, Chantal Pauli, Darryl D D’Lima, Martin Lotz, Robert L Sah Poster No. 1722 A Decrease of the Cytoskeleton Components is associated with an alteration of Viscoelastic Properties in Aged Chondrocytes Lei Wei, Wangping Duan, Yuzhi Wei, Xiaochun Wei Poster No. 1723 Hyaluronan Concentration and Size Distribution in Human Knee Synovial Fluid: Variations with Age and Cartilage Degeneration Michele M Temple-Wong, Phu Quach, Brian J Archer, Bradley C Hansen, Albert Chen, Akihiko Hasegawa, Darryl D D’Lima, William D Bugbee, Martin K Lotz, Robert L Sah Poster No. 1724 TIMP2 Deficient mice Enhanced Osteoarthritis-like Phenotype after Destabilization of the medial meniscus (DMM) Meng Mi, ShanShan Shi, Tianfang Li, Jonathan Holz, Jennifer Jonason, Lin Gao, Tzong-jen Sheu, Regis J O’Keefe, J. Edward Puzas 139 PS2 Cartilage/Meniscus/ Synovium - Cartilage Repair Posters Poster No. 1725 Fiber-Reinforced Interpenetrating Network Hydrogels for Articular Cartilage Repair I-Chien Liao, Frank Moutos, Brad Estes, Xuanhe Zhao, Farshid Guilak Poster No. 1726 Fibroblast Growth Factor 2 Incorporating Biodegradable Gelatin Hydrogels Promote Healing of Horizontal Tears in Rabbit Meniscus: Histology and Immunohistochemistry Atsushi Narita, Masatoshi Takahara, Daisuke Sato, Tamon Asano, Toshihiko Ogino, Shigenobu Fukushima, Yasuhiko Tabata Poster No. 1727 Non-Degradable Porous Poly(Vinyl Alcohol) Hydrogels for Cartilage Tissue Engineering Hatice Bodugoz-Senturk, David Bichara, Doris Ling, Chhavi Gupta, Mark Randolph, Orhun K Muratoglu Poster No. 1728 Hyaluronic Acid Enhances the Effect of the PAMPS/PDMAAm Double-network Hydrogel on Chondrogenic Differentiation of ATDC5 Cells Nobuto Kitamura, Takayuki Kurokawa, Hyuck J Kwon, Takaaki Fukui, Yoshihiro Ohmiya, Jian P Gong, Kazunori Yasuda Poster No. 1729 A Novel Method to quantify Wear of Hydrogels using Submerged Measurements Doruk Baykal, Judd W Day, Jay Katta, Kevin Mansmann, Steven M Kurtz Poster No. 1730 Co-encapsulation of TGF-β1 into Negatively Charged Oligo(polyethylene glycol) Fumarate (OPF) Hydrogels to Enhance Chondrogenesis Michelle Casper, Michael J Yaszemski, Mahrokh Dadsetan Poster No. 1731 The Effects of Hyaluronic acid using the Combination Treatment of Ultrasound Sonophoresis and Microbubbles Cavitation in a Monolayer Culture Model of Rabbit Chondrocyte Akio Eguchi, Tomoyuki Nakasa, Nobuo Adachi, Masataka Deie, Katsuro Tachibana, Toshiyuki Kikuchi, Mitsuo Ochi Poster No. 1732 Effect of Irradiation on the Strength and Lubricity of PVA-PAA Hydrogels for Cartilage Repair Doris Ling, Hatice Bodugoz-Senturk, Heather Lynn Kluk, Orhun K Muratoglu Poster No. 1733 Development of the intra-articular injectable controlled-release PTH(1-34)/HA-MA hydrogel for osteoarthritis treatment Yao-Hsien Wang, Hsueh Chun Wang, Rajalashmanan Eswaramoorthy, Je-ken Chang, Gwo-Jaw Wang, Mei Ling Ho 140 Poster No. 1734 Investigation of PLGA Nanoparticle Transport into Cartilage Relevant to Osteoarthritis Drug Delivery Systems Ambika Goel, Pedro Valenica, Rohit Karnik, Alan J Grodzinsky Poster No. 1735 In Vivo Repair of Critical-Sized Cartilage Defects Using Large-Sized, Scaffold-Free Constructs Jillian Brenner, Yat Tse, Judy Pang, Andrew Winterborn, Davide Bardana, Steve Pang, Stephen D Waldman Poster No. 1736 The Influence of Dynamic Loading on Bio-Titanium Hybrid Osteochondral Tissue Engineered Constructs Adam B Nover, Mary T Ye, Stefania K Samojlik, Grace D O’Connell, Gerard A Ateshian, Eric G Lima, Clark T Hung Poster No. 1737 Hyaluronic acid increases proliferation and improves redifferentiation of isolated osteoarthritic chondrocytes Karolina A Wijnands, Edwin J Jansen, Tim M Welting, Don A Surtel, Lodewijk W van Rhijn, Pieter J Emans Poster No. 1738 Culture of Primary Bovine Chondrocytes on Silicone Rubber Modified with Crude Collagen Type II Extract Derek H Rosenzweig, Sofia S Cafaggi, Thomas M Quinn Poster No. 1739 Repair of Focal Chondral Defects in Porcine Model Using Fresh or Fresh-Frozen Multiply Incised Pure Cartilage Allograft Jozsef Vancsodi, Adam Fazekas, Orsolya Boda, Arpad Bellyei, Tamas Illes, Tamas Bardos Poster No. 1740 Correlation of histological and functional results following ACI-c / MACI for osteochondral defects of the knee Andreas S Shekkeris, Jonathan P Perera, George Bentley, Jonathan Miles, Richard W Carrington, John A Skinner, Tim W Briggs Poster No. 1741 Chondrocyte genetic typing of massive fresh osteochondral allografts at 18 months after transplantation: are the cells still from the donor? Simona Neri, Francesca Vannini, Roberto Buda, Alberto Ruffilli, Marco Cavallo, Giovanna Desando, Brunella Grigolo, Andrea Facchini, Sandro Giannini Poster No. 1742 Combination of Osteotomy with Autologous Chondrocyte Implantation for treatment of early Osteoarthritis of Knee A. Bhattacharjee, L. Goebel, A. Quereshi, J. H Kuiper, N. Duggard, M. Henning, J. B Richardson Poster No. 1743 A Comparison of Photosensitizers to Promote Photochemical Bonding of Articular Cartilage Defects Ivan J Wong, Francisco De La Paz, Marc E Levenston Poster No. 1745 Cartilage Allograft Stabilization with Glutaraldehyde as a Potential Resurfacing Material for Joint Hemiarthroplasty Sevan R Oungoulian, Orian Bortz, Steven Xu, Stephany Chang, Christopher S Ahmad, Clark T Hung, Gerard A Ateshian PS2 Cartilage/Meniscus/Synovium Cartilage Repair - Cell-Based Approaches Poster No. 1746 Use of Homing Molecules as an Adjunct in Articular Cartilage Repair Noah Chitnitz, Daniel A Grande, Pasquale Razzano, Anthony Catanzano, Zev Klapholz, Neil V Shah, John Schwartz, Nadine Chahine Poster No. 1747 Extracellular matrix rescues human synovium-derived stem cells from oxidative stress and enhances expanded stem cell chondrogenesis Ying Zhang, Jingting Li, Ming Pei Poster No. 1748 Young microenvironment rejuvenates aged human synovium-derived stem cells toward chondrogenesis Jingting Li, Ying Zhang, Ming Pei Poster No. 1749 True or false: a tissue-specific microenvironment favors human synovium-derived stem cell chondrogenesis Jingting Li, Fan He, Vincent L Kish, Ming Pei Poster No. 1750 Low seeding density favors human synovium-derived stem cell proliferation and multi-lineage differentiation capacity Jingting Li, Brendan Jones, Ying Zhang, Ming Pei Poster No. 1751 In situ recruitment of human bone marrow-derived mesenchymal stem cells for articular cartilage regeneration Min Sung Park, Yun Hee Kim, Jin Woo Lee Poster No. 1752 Adipose-Tissue Derived Mesenchymal Stem Cells Affect Metabolism of Chondrocytes Derived from Patients with Osteoarthritis Chris H Jo, Hyang. Kim, Qiu Yu Jiang, Ji Eun Kim, Young Gil Lee, Pil Hwan Yoon, Kang Sup Yoon Poster No. 1753 Durable In Vitro Cartilage Repair and Functional Load Transmission with MSC-Seeded Hyaluronic Acid Hydrogels Isaac Erickson, Kilief H Zellars, Brian D Cosgrove, Jason Burdick, Robert L Mauck Poster No. 1754 Regenerative Capacity of Synovium-Derived Mesenchymal Stem Cells into Rabbit Partial-Thickness Chondral Defect through Intraarticular Injection Jae-Chul Lee, Hyun Jin Min, Sung Young Wang, Jak Jang, Sanghoon Lee, Sang Chul Seong, Myung chul Lee Posters Poster No. 1744 Analysis of Osteochondral Allograft Metabolism Using Various Preservation Protocols at 25°C Aaron M Stoker, James L Cook Poster No. 1755 Co-Culture of Synovium Derived Stem Cells Induces Cell Migration into Adjacent Wound Sites within Chondrocyte-Seeded Engineered Cartilage Andrea R Tan, Elena Alegre Aguarón, J. C Bulinski, Gerard A Ateshian, Clark T Hung Poster No. 1756 Mesenchymal Stem Cells Transplantation to the Knee Joint of Hartley Strain Guinea Pig with Spontaneous Osteoarthritis MItsuhiko Sato, Kenzo Uchida, Hideaki Nakajima, Tsuyoshi Miyazaki, Alexander R Guerrero, Shuji Watanabe, Sally Roberts, Hisatoshi Baba Poster No. 1757 Improved expansion of human chondrocytes Thomas J Kean, James E Dennis Poster No. 1758 Radiation Induced Proliferation of Growth Plate Chondrocytes Embedded in the Alginate 3D Matrix Kimo Bachiashvili, Lihini S Keenawinna, Daniela A Marshall, Timothy A Damron PS2 Cartilage/Meniscus/ Synovium - Meniscus Poster No. 1759 Mechanial stretch enhances COL2A1 expression on chromatin by inducing SOX9 nuclear translocalization in inner meniscus cells Tomoko Kanazawa, Takayuki Furumatsu, Nobuhiro Abe, Yusuke Yokoyama, Naoki Takata, Toshifumi Ozaki Poster No. 1760 Syngeneic, minor mismatched, and major mismatched transplantation of synovial mesenchymal stem cells in a rat massive meniscal defect model Makiko Okuno, Ichiro Sekiya, Koji Otabe, Hiroki Katagiri, Nobutake Ozeki, Masafumi Horie, Hideyuki Koga, Kunikazu Tsuji, Shinichi Yoshiya, Takeshi Muneta Poster No. 1761 Quantitative Insertion Morphology of the Posterior Meniscal Root in Relation to the Posterior Cruciate Ligament Verena M Schreiber, Snehal Shetye, Gele Moloney, Paulo Araujo, Robert Carey, Xudong Zhang, Christopher D Harner Poster No. 1762 A potential biological mechanism for meniscus involvement in osteoarthritis Austin V Stone, Richard F Loeser, David L Long, Cristin M Ferguson Poster No. 1763 A Novel Fiber-Reinforced Scaffold for Reconstruction of the Meniscus Aaron Merriam 141 Posters Poster No. 1764 Chondromodulin-I regulates avascularity and healing potential of human meniscus Yusuke Yokoyama, Takayuki Furumatsu, Tomoko Kanazawa, Naoki Takata, Nobuhiro Abe, Toshifumi Ozaki Poster No. 1765 Inner meniscus cells maintain higher chondrogenic phenotype compared with outer meniscus cells Takayuki Furumatsu, Tomoko Kanazawa, Yusuke Yokoyama, Naoki Takata, Nobuhiro Abe, Toshifumi Ozaki Poster No. 1766 In Vivo Meniscus Kinematics and Deformation Using MR Image 3D Modeling Jaehun Ro, Hui-jeong Lee, Choongsoo S Shin Poster No. 1767 Widening after cyclic load and fixation strength of three techniques of trans-capsular meniscal repair based on clinical situation Iuchi Ryo, Mae Tatsuo, Shino Konsei, Matsuo Tomohiko, Matsumura Nobumasa, Kita Keisuke, Yoneda Minoru, Yoshikawa Hideki, Nakata Ken Poster No. 1768 Relative Contacts between the Medial Meniscus and Exposed Cartilage in the Knee Christopher Bell, Sally Arno, Scott Hadley, Kirk Campbell, Michael Hall, Luis Beltran, Michael Recht, Orrin Sherman, Peter S Walker Poster No. 1769 Cell/Biomaterial Strategies for Meniscus Repair Eli Chen, Matthew Goldstein, Steven Sheng, Nadeen O Chahine, Pasquale Razzano, Ashley Olson, Sohum A Patwa, Nicholas A Sgaglione, Daniel A Grande Poster No. 1770 Specific Candidate for Meniscus Tissue Engineering Based on Laminated Green Materials and Simple Method Melika Sarem, Fathollah Moztarzadeh, Masoud Mozafari Poster No. 1771 New Suture Method for the Radial Tears of the Meniscus: Biomechanical Analysis of Cross Suture Technique and Double Horizontal Suture Technique Using Cyclic Load Testing Hirokazu Matsubara, Ken Okazaki, Toshiaki Izawa, Yasutaka Tashiro, Shuichi Matsuda, Takuya Nishimura, Yoshitaka Nakanishi, Yukihide Iwamoto PS2 Cartilage/Meniscus/ Synovium - Cell and Molecular Imaging of Cartilage Poster No. 1772 Depth and Orientational Dependencies of MRI T2 and T1ρ towards Trypsin Degradation and Gd-DPTA2- Presence in Articular Cartilage at Microscopic Resolution Yang Xia, Nian Wang Poster No. 1773 WITHDRAWN 142 Poster No. 1774 Quantifying the Effect of Injury on Cartilage Viability using a Novel Multiphoton Microscopy Tool Kira Novakofski, Rebecca Williams, Lisa Fortier, Lawrence Bonassar Poster No. 1775 WITHDRAWN Poster No. 1776 T2 relaxation time mapping of articular cartilage of radiocarpal joint : Comparison between healthy subjects and patients with rheumatoid arthritis Atsushi Kitagawa, Tomoko Nakamura, Tetsuhiro Iguchi Poster No. 1777 Quantitative Analysis of the Depth−Dependent Ultrastructure of Articular Cartilage Robert Stefani, Roy K Aaron, Bahar Bilgen Poster No. 1778 Repeatability and Correlation with Clinical Measures of Articular Cartilage Thickness Measurement by B-mode Ultrasonography with Mechanical 3D Scanning Satoru Ohashi, Isao Ohnishi, Kenji Tobita, Masako Kaneko, Takuya Matsumoto, Masahiko Bessho, Kozo Nakamura Poster No. 1779 Ultrasound arthroscopy of articular cartilage in human shoulder joint in vivo Jani Puhakka, Teemu Paatela, Markus Sormaala, Matti Timonen, Tuomas Viren, Jukka S Jurvelin, Juha Töyräs, Ilkka Kiviranta Poster No. 1780 Could Whole-Organ Magnetic Resonance Imaging Score (WORMS) Components Predict Pain in Knee Osteoarthritis? Julien Wegrzyn, Michele D’Apuzzo, Kimberly Amrami, Dirk Larson, Kenton Kaufman Poster No. 1781 Solute Adsorption to Articular Cartilage Surfaces: Apparent Versus Actual Equilibrium Partition Coefficients Mohammad Moeini, Thomas M Quinn Poster No. 1782 Solute Transport Across the Articular Surface of Mechanically Injured Cartilage Hooi C Chin, Mohammad Moeini, Thomas M Quinn PS2 Cartilage/Meniscus/ Synovium - Osteoarthritis Poster No. 1783 Mechanically Induced Changes in COMP Concentrations Predict Changes in Cartilage Thickness after 5 Years Jennifer Erhart Hledik, Anne Mundermann, Julien Favre, Lane Smith, Thomas Andriacchi Poster No. 1784 Initial Analysis and Comparison of Synovial Fluid Biomarker Concentrationsin Juvenile and Adult Canines Aaron M Stoker, Sarah Timmerman, Keiichi Kuroki, James L Cook Poster No. 1795 Characterization of the Spatial Cartilage Thickness Distribution on the Distal Femur in Healthy Knees Julien Favre, Katerina Blazek, Jennifer Erhart Hledik, Thomas Andriacchi Poster No. 1786 Therapeutic Interventions to Inhibit Cartilage Degeneration, Promote Cartilage Repair, and Prevent the Development of Post-Traumatic OA Rylee Olewinski, Markus A Wimmer, Arnavaz A Hakimiyan, Lev Rappoport, Carol Pacione, Susanna Chubinskaya Poster No. 1796 Genome-wide Transcriptional Profiling Implicates Inflammatory Genes LRP8, IL10RA, LDLR, and PLA2G2A in Osteoarthritis Ahsan Choudary, Heather B Coan, Daniel P Nicolella, Joanne E Curran, Melanie C Carless, Satish Kumar, John W Kent, Laura A Almasy, Harald H Goring, John Blangero, Michael C Mahaney, Lorena M Havill Poster No. 1787 Markers of Type-II Collagen Metabolism and Kellgren & Lawrence Grade in Early Post Traumatic Osteoarthritis Timothy W Tourville, Robert J Johnson, Shelly Naud, Maria Roemhildt, James R Slauterbeck, Bruce Beynnon Poster No. 1797 The Incidence and Structure of the Fabella in Japanese Population.Anatomical Study, Radiographic Study, and Clinical CasesYuki Kato, Midori Oshida, Keinosuke Ryu, Takashi Horaguchi, Masayuki Seki, Yasuaki Tokuhashi Poster No. 1788 Inflammatory Cytokine Composition and Metabolic Profile of PostTraumatic Ankle Joint Arthritis Samuel B Adams, Elizabeth Kensicki, Lynne Jones, Azeb Haile, Stuart D Miller, Gregory P Gutyon, Lew C Schon Poster No. 1798 Relationship of Vascular Endothelial Growth Factor Expression and Knee Osteoarthritis Severity Natthaphon Saetan, Sittisak Honsawek, Aree Tanavalee, Pongsak Yuktanandana Poster No. 1789 Soluble CD14 in Synovial Fluid from Patients with Early-Stage Osteoarthritis Augments Fibroblast-like Synoviocyte Responses to Lipopolysaccharide (LPS) Carla R Scanzello, Anjali Nair, Veero Kanda, Charles Bush-Joseph, Nikhil Verma, Susanna Chubinskaya, Katalin Mikecz, Tibor T Glant, Anne-Marie Malfait, Mary K Crow, Alison Finnegan Poster No. 1799 Improving frontal-plane neuromuscular control and stability in medial knee OA through subject-specific multi-axis neuromuscular training Song Joo Lee, Alison Chang, Yupeng Ren, Joel Press, Li-Qun Zhang Poster No. 1790 A Biomarker Panel for Evaluating the Outcome of Rehabilitation in Patients with Osteoarthritis Prakash Jayabalan, Aaron M Stoker, Stephen Sayers, James L Cook Poster No. 1791 Clinical Significance of Cartilage Biomarkers for Monitoring Structural Joint Damage in Rheumatoid Arthritis Patients Treated with Anti-TNF Therapy Yasuo Niki, Tsutomu Takeuchi, Masanori Nakayama, Hiroya Kanagawa, Eri Katsuyama, Yoshiaki Toyama, Takeshi Miyamoto Poster No. 1792 Detection of Natural Antibodies Reactive with Inflammatory Pain Agents is a Key to Study and Follow Patients with Osteoarthritis Yulia A Savitskaya, Alfonso Alfaro, Norma Marin, Rene Tellez, Carolina Duarte, Clemente Ibarra Poster No. 1793 Can intra-articular cytokine profiling predict the development of knee pain? Four-year follow-up of asymptomatic controls Jason M Cuellar, S. Raymond Golish, Vanessa G Cuellar, Yohan Song, Lewis S Hanna, Gaetano Scuderi Poster No. 1794 Comparison of Cartilage Histopathology Assessment Systems on Human Knee Joints at All Stages of Osteoarthritis Development Chantal Pauli, Robert Whiteside, Facundo Lasheras, Dobrila Nesic, James Koziol, Shawn P Grogan, John Matyas, Kenneth Pritzker, Darryl D D’Lima, Martin K Lotz Posters Poster No. 1785 Osteopontin level in synovial fluid is transiently upregulated after joint injury and associated with the severity of knee joint pain Mika Yamaga, Kazumasa Miyatake, Ichiro Sekiya, Takeshi Muneta, Kunikazu Tsuji Poster No. 1800 Structure-Function Relationships in Osteoarthritic Articular Cartilage of Human Hip Joint Janne T Mäkelä, Mari R Huttu, Rami K Korhonen Poster No. 1801 Hip Synovial Fluid Cytokine Profiling In Osteoarthritis Versus Labral Pathology Patient Populations Geoff Abrams, Raymond Golish, Wayne J Olan, Marc J Philippon, Jodie A Stone, Lewis S Hanna, Gaetano Scuderi Poster No. 1802 Two-year post-surgical outcomes in patients undergoing arthroscopic partial meniscectomy: The influence of synovitis Carla R Scanzello, Anthony Albert, Edward DiCarlo, Kumar B Rajan, Eva U Asomugha, Veero Kanda, Bryan Swaim, Paul Weitzel, John C Richmond, Steven R Goldring, Brian McKeon Poster No. 1803 Predicting Symptomatic Progression of Osteoarthritis Anish Ghodadra, Flavia Sakamoto, Prabhakar Rajiah, Carl Winalski, Anthony Miniaci, Morgan H Jones Poster No. 1804 WITHDRAWN Poster No. 1805 Relationship Between Arthroscopic Findings at the Time of ACL Reconstruction and Tibiofemoral Joint Space Width Timothy W Tourville, Robert J Johnson, Shelly Naud, James R Slauterbeck, Bruce Beynnon 143 PS2 Cartilage/Meniscus/ Synovium - Cartilage Mechanics Posters Poster No. 1806 Application of Chemical and Dynamic Mechanical Stimuli to the Surface of Immature Articular Cartilage Induces Functional and Structural Maturation of the Superficial Zone Quynhhoa T Nguyen, Daniel J Crawford, Christopher B Raub, Albert C Chen, Stephen M Klisch, Robert L Sah Poster No. 1807 Rest Period after Cyclic Loading Enhances Mechanical Stimulation of Osteogenic Factors Bone Morphogenetic Protein 2 and Type X Collagen Gene Expression in Chondrocytes Edward Cheung, Xu Yang, Qian Chen Poster No. 1808 Dietary Vitamin D Deficiency Disrupts Periodic Pattern of Growth Plate Mechanical Properties Derin Sevenler, Mark R Buckley, Grace Kim, Marjolein van der Meulen, Itai Cohen, Lawrence Bonassar Poster No. 1809 Surface Proteoglycan Depletion Controls Lubrication Mode Transition of Articular Cartilage Natalie Galley, Darvin Griffin, Lawrence Bonassar Poster No. 1810 Spatial and Temporal Distributions of ERK Activity in Mechanically Injured Cartilage Explants Derek H Rosenzweig, Melissa Djap, Thomas M Quinn Poster No. 1811 Cartilage-on-Cartilage Impacts Induce Differing Chondrocyte Injury Characteristics When Compared to Metal-on-Cartilage Impacts Kyle Judd, Anneliese Heiner, Abigail Lehman, Todd McKinley Poster No. 1812 Load-Induced Alteration of Bone and Cartilage Properties in the Rat Tibia Plateau Maria Roemhildt, Mack Gardner-Morse, Bruce Beynnon, Kiley Anderson Poster No. 1813 WITHDRAWN Poster No. 1814 Effect of X-Ray Irradiation on Porcine Articular Cartilage Using an Explant Model Alex Lindburg, Jeff S Willey, Shea A Bielby, John D DesJardins, Delphine Dean Poster No. 1815 The 3D microenvironment modulates chondrocyte mechanics - an inverse finite element approach David A Lee, Jinju Chen, Dan L Bader, Martin M Knight Poster No. 1816 The Role of the Superficial Tangential Zone in Determining the Dynamic Properties of Articular Cartilage Alanna R Gannon, Daniel J Kelly 144 Poster No. 1817 Subchondral bone density affects cartilage tissue stresses Andrew Speirs, Paul Beaulé, Stephen J Ferguson, Hanspeter Frei Poster No. 1818 Mechanical Evaluation of the Mechanism of Load Transfer in Articular Cartilage Sayyed Mohsen Hosseini, Yabin Wu, Keita Ito, Corrinus C van Donkelaar Poster No. 1819 Effects of Indentation Rate and Contact Radius on the Local Response of Cartilage Edward D Bonnevie, Vincent Baro, Liyun Wang, David L Burris Poster No. 1820 Location dependent properties of cartilage measured by ultrasound and indentation: Two case studies of ovine and minipig knee articular cartilage Reza Abedian Dehaghani, Nils Maennicke, Martin Schoene, Kay Raum, Christof Hurschler Poster No. 1821 Magnesium Alloys for the Temporomandibular Joint: What are acceptable ion levels? Catherine K Hagandora, Alejandro J Almarza Poster No. 1822 Mechanical Loading and Sliding Speed Dependent Frictional Coefficient of TMJ Cartilage and Disc X. Lucas Lu, Edward D Bonnevie, Laura Barito, Vincent Baro, Miri Park, Liyun Wang, David L Burris Poster No. 1823 Relationships between cell volume, structure, composition and mechanical properties of osteoarthritic human hip articular cartilage Mari R Huttu, Jani Puhakka, Janne Mäkelä, Yuya Takakubo, Virpi Tiitu, Simo Saarakkala, Yrjö Konttinen, Ilkka Kiviranta, Rami Korhonen PS2 Cartilage/Meniscus/ Synovium - Mechanobiology Poster No. 1824 Prostaglandin E2 upregulation by cyclic compressive loading on 3-D tissue of human synovial fibroblasts via COX-2 and IL-1 receptor signal pathway Kazunori Shimomura, Keisuke Kita, Takashi Kanamoto, Norimasa Nakamura, Tatsuo Mae, Hideki Yoshikawa, Ken Nakata Poster No. 1825 Chondrocyte Migration is Modulated by Osmotic Environment Shin-Min Wen, Andrea R Tan, Clark T Hung, Pen-hsiu Grace Chao Poster No. 1826 Response of Synovium Derived Stem Cells to an Applied DC Electric Field After Passage with Growth Factors Andrea R Tan, George P Ackerman, Curtis D Vandenberg, Matthew V Dermksian, J. C Bulinski, Clark T Hung Poster No. 1827 Electromagnetic Fields counteract IL-1beta Activity during Chondrogenesis Setti Stefania, Alessia Ongaro, Agnese Pellati, Angelo Caruso, Michela Battista, Ruggero Cadossi, Leo Massari, Monica De Mattei Poster No. 1839 In-Vivo Patellofemoral Articular Contact Kinematics During WeightBearing Deep Knee Flexion Koichi Kobayashi, Makoto Sakamoto, Harry Rubash, Guoan Li Poster No. 1829 Local Anesthetics and Corticosteroids: A Chondrotoxic Combination Hillary J Braun, Nathaniel Wilcox-Fogel, Hyeon Joo Kim, Michael A Pouliot, Alex H Sox-Harris, Jason Dragoo Poster No. 1840 Reliability and Predictability of Static MR Joint Alignment Surrogates for Predicting 3D Patellofemoral Kinematics Benjamin R Freedman, Frances T Sheehan Poster No. 1830 The Chondrotoxicity of Single-Dose Local Anesthetics Jason Dragoo, Hillary J Braun, Hyeon Joo Kim, Raymond Golish PS2 Disease Process Knee - Joint Mechanics Poster No. 1831 Three-dimensional knee kinematics in patients with lateral discoid meniscus during gait Kengo Harato, Aiko Sakurai, Yutaka Kudo, Tomoe Iida, Naoka Sunada, Takeo Nagura, Yoshimori Kiriyama, Kou Masumoto, Toshiro Otani Poster No. 1832 The Effects of Toe Directions on Knee Kinematics and Kinetics during Drop Vertical Jump Tomoya Ishida, Masanori Yamanaka, Kentaro Homan, Naoki Takeda, Yoshimitsu Aoki Poster No. 1833 ACL Injury Combined with Medial or Lateral Meniscus Tear Altered the Knee Joint Kinematics Differently Jing-Sheng Li, Ali Hosseini, Ryan Finn, Lucile J Cancre, Thomas J Gill, Guoan Li Poster No. 1834 Relationship between MRI intensity of ACL graft and anteroposterior stability of the knee after anatomical double-bundle ACL reconstruction Akihiro Hakozaki, Yasuo Niki, Wataru Iwamoto, Hiroya Kanagawa, Yuuki Takeda, Eri Katsuyama, Hedeo Matsumoto, Fumihiro Yashimine, Toshiro Ohtani, Hiroyuki Enomoto, Yoshiaki Toyama, Yasunori Suda Poster No. 1835 Articular and meniscal cartilage respond differently to functional loading Deepak Kumar, K. Subburaj, Hamza Alizai, Samuel Wu, Nishant Neel, Kelly Bauer, Anthony Luke, Xiaojuan Li, Thomas Link, Richard Souza Poster No. 1836 The Significance of Knee Pain on Stair Ascent and Descent Fred Nelson, Anthony Galinato Poster No. 1837 Analysis of tibiofemoral center of pressures indicates high variability with ACL reconstruction Saad Sheikh, Craig Mauro, Dan Choi, Thomas Wickiewicz, Carl Imhauser Poster No. 1838 Does the Side of Meniscus Injury Affect the Tibiofemoral Cartilage Contact in ACL-deficient Patients? Ali Hosseini, Jing-Sheng Li, Sowmya Varada, Kamal Patal, Thomas J Gill, Guoan Li Posters Poster No. 1828 Electromagnetic Fields modulate HLA-G Molecules in Osteoarthritic Synovial Fibroblasts Stefania Setti, Alessia Ongaro, Agnese Pellati, Angelo Caruso, Michela Battista, Ruggero Cadossi, Leo Massari, Roberta Rizzo, Monica De Mattei Poster No. 1841 A Vasti Medialis Nerve Block Alters In Vivo Knee Joint Kinematics: Implications for Patellofemoral Pain Syndrome Frances T Sheehan, Bhushan S Borotikar, Abrahm Behnam, Katharine Alter Poster No. 1842 In Vivo Application of Novel and Commercially Available Bioabsorbable Implants for Tibial Fixation of Anterior Cruciate Ligament Reconstruction Grafts Mandi J Lopez, Prakash Bommala, Laura Kelly, Nan Zhang, William T Monroe Poster No. 1843 The Potential Risk of Anterior Tibial Cortex Damage in Transtibial Technique for Anatomical Double Bundle Anterior Cruciate Ligament Reconstruction Yasuhiro Nishimori, Masahiro Nozaki, Masaaki Kobayashi, Hideyuki Goto, Masahito Yoshida, Kaneaki Tawada, Atsunori Murase, Nobuyuki Watanabe, Hirotaka Iguchi Poster No. 1844 A robotic in vivo evaluation of loading characteristics of different anterior cruciate ligament reconstructions Cale Jacobs, Thomas P Branch, Tommy J Cunningham, Shaun K Stinton, Howard I Freedberg, Jon E Browne, Todd M Wente Poster No. 1845 Biomechanical Evaluation of Knee Joint Laxities and Graft Forces following Anterior Cruciate Ligament Reconstruction by Anteromedial Portal, Outside-In, and Transtibial Techniques Jae-Ang Sim, Hemanth R Gadikota, Jing-Sheng Li, Guoan Li, Thomas J Gill Poster No. 1846 Primary Stability of a New Technique for Tibial Fixation of a Free Tendon Graft in ACL Reconstruction: The Retrograde Shim Technique Simon Lenschow, Füterer Jana, Mirco Herbort, Mike Schroeglmann, Michael J Raschke, Benedikt Schliemann Poster No. 1847 Double Bundle ACL Reconstruction Limits Side-to-Side Extension in Knees with Hyperextension Capacity Max Ettinger, Carl Haasper, Christian Krettek, Urs-Vito Albrecht, Michael Jagodzinski 145 Posters Poster No. 1848 Gait Symmetries in ACL Non-Copers who Receive Perturbation After Surgery, Compared to Pre-Operative Perturbation Training Kathleen White, Stephanie Di Stasi, Lynn Snyder-Mackler Poster No. 1859 A Robust Physiologically Relevant In-Vitro Testing Method for the Tibiofemoral Joint Fred Wentorf, Charles Praduhn, Nick Oblizajek, Amitkumar Mane Poster No. 1849 Muscle activation as a function of graft type in ACL reconstruction Chelsea A Marsh, Scott Tashman PS2 Disease Process Hip Poster No. 1850 Loading Asymmetries in Athletes Who Do and Do Not Meet Returnto-Sport Criteria Emily S Gardinier, Stephanie L Di Stasi, Kurt Manal, Thomas S Buchanan, Lynn Snyder-Mackler Poster No. 1851 Limited Benefit of Hamstrings Forces for the ACL Deficient Knee John J Elias, Marcus S Kirkpatrick, Matthew J Stonestreet, Kushal S Shah, Caroline E Frampton, Melanie A Morscher, Kerwyn C Jones Poster No. 1852 Intercondylar Notch Width and ACL Cross-Sectional Area Predict Peak ACL Strain Christopher J Bush, David B Lipps, James A Ashton-Miller, Edward M Wojtys Poster No. 1853 Relation of Knee Extensor Moment Arm and Patellar Tendon Angles to Anterior Cruciate Ligament Injury Risk in Females Joshua L Carter, Helen Smith, Dan Sturnick, Aaron Scheinman, Mack Gardner-Morse, James Slauterbeck, Robert Johnson, Bruce Beynnon Poster No. 1854 Knee Joint Geometry Characterization: Local Curvature in Relationship with ACL Injury Risk Bruce D Beynnon, Daniel R Sturnick, Yves Dubief, Helen C Smith, Aaron Scheinman, Pamela Vacek, Leigh Anne Holterman, Mack Gardner-Morse, Timothy W Tourville, James Slauterbeck, Ira Burnsteing, Sandra Shultz, Javad Hashemi, Robert Johnson Poster No. 1861 A Radiographic Assessment of CAM-Type Femoroacetabular Impingement Morphology in the Developing Hip Paul Beaulé, Sasha Carsen, Baxter Willis, Leanne Ward, Hal Dunlap, Kawan Rakhra, Paul Moroz Poster No. 1862 T2* Mapping of Acetabular and Femoral Hip Joint Cartilage at 3 T: A Prospective Controlled Study Bernd Bittersohl, Falk Miese, Harish S Hosalkar, Tallal C Mamisch, Gerald Antoch, Rüdiger Krauspe, Christoph Zilkens Poster No. 1863 Femoroacetabular Impingement, is Cartilage Degeneration a Continuum? Arturo Cárdenas-Blanco, Mark Schweitzer, Kawan Rakhra, Paul Beaulé Poster No. 1864 Proximal Femoral Shape Variations of Legg-Calvé-Perthes Disease and Slipped Capital Femoral Epiphysis Elaine F Chan, Christine L Farnsworth, Ricky Harjanto, Harish S Hosalkar, Robert L Sah Poster No. 1865 A 3-D Alpha angle: an improved method to quantify and plan cam hip surgery Milad Masjedi, David Azimi, Craig Nightingale, Kinner Davda, Justin Cobb Poster No. 1855 The Relationship between Ambulatory Load and Cartilage is Influenced by Age and Gender Katerina Blazek, Julien Favre, Jessica Asay, Jennifer Erhart, Thomas Andriacchi Poster No. 1866 Comparing EOS with Plain Radiography for Pelvis Imaging: Does it Matter Which I Choose? Joana M Freitas, James D Bomar, Abd Razak Muhamad, Christine L Farnsworth, Harish S Hosalkar Poster No. 1856 The Anterior Cruciate Ligament Changes in Human Joint in Aging and Osteoarthritis Akihiko Hasegawa, Shuhei Otsuki, Chantal Pauli, Shigeru Miyaki, Mitsuo Kinoshita, James Koziol, Darryl D D’Lima, Martin Lotz Poster No. 1867 A Novel Method for Determining Acetabular Orientation from 3-D Scans Sean Higgins, Richard Boe, William Jiranek, Jennifer Wayne Poster No. 1857 Friction Properties of Synovial Joint Lubrication by Precise Tracking Pendulum Tester Masahiro Todoh, Shigeru Tadano, Norimasa Iwasaki Poster No. 1858 Localized Strain Elevation in the Lateral Retinaculum of the Knee during Flexion S. Durrani, S. Ismaily, D. Daylamani, P. Ramkumar, J. Gold, P. Noble 146 Poster No. 1860 Femoral and Acetabular Version in Hip Impingement Andrew Speirs, Hanspeter Frei, Kawan Rakhra, Paul Beaulé Poster No. 1868 Measurement of Antero-Posterior Instability of Femoral Head on MRI in Reference to the Progress of Hip Osteoarthritis Hirotsugu Ohashi, Fumiaki Inori, Hirotake Yo, Yoshiaki Okajima, Yoshio Matsui, Kousuke Shintani, Mutsumi Morinishi Poster No. 1869 Evaluation of Hip Translation using Three-Dimensional Magnetic Resonance Imaging Keisuke Akiyama, Takashi Sakai, Junichiro Koyanagi, Hideki Yoshikawa, Kazuomi Sugamoto Poster No. 1871 Incidence Rate of Non-Traumatic Osteonecrosis of the Femoral Head in the Japanese Population Ryosuke Yamaguchi, Takuaki Yamamoto, Goro Motomura, Satoshi Ikemura, Kenyu Iwasaki, Garida Zhao, Yukihide Iwamoto Poster No. 1872 Acetabular retroversion after Pemberton Osteotomy Mio Akiyama, Yasuharu Nakashima, Taishi Sato, Masanobu Hirata, Yukihide Iwamoto Poster No. 1873 High IL-8 Level of Synovial Joint Fluid in Hips with Rapidly Destructive Coxopathy Hirohito Abe, Takashi Sakai, Wataru Ando, Masaki Takao, Takashi Nishii, Nobuo Nakamura, Hideki Yoshikawa, Nobuhiko Sugano Poster No. 1874 A study of the incoming low-intensity pulsed ultrasound (LIPUS) to the inside of the femoral head -The possibility of treating femoral head osteonecrosis with LIPUSHisashi Sugaya, Hajime Mishima, Meihua Li, Takeshi Ogawa, Jun Takeda, Naoko Kamada, Takamitsu Okayama, Koji Tomimori, Masataka Sakane, Naoyuki Ochiai Poster No. 1875 Clinical Effectiveness of Continuous Passive Motion (CPM) Following Hip Surgery in Children Harish S Hosalkar, James D Bomar Poster No. 1876 Reproducibility and Reliability of Plain Radiographic Parameters of DDH in Children James D Bomar, Vidyadhar Upasani, Gaurav Parikh, Harish S Hosalkar PS2 Gait and Kinematics, Kinesiology Poster No. 1877 Wearing athletic footwear alters sagittal plane knee mechanics in walking and running Hidenori Tanikawa, Kengo Harato, Hideo Matsumoto, Yoshimori Kiriyama, Yoshiaki Toyama, Takeo Nagura Poster No. 1878 Differences in Dynamic Joint Stability Between Dominant and Contralateral Knees in Healthy Individuals Emily Bishop, Diane Kukulski, Craig Mathison, William Enns-Bray, Cy Frank, Janet Ronsky Poster No. 1879 Side-to-side comparison of knee kinematics and kinetics during a single-leg drop landing from two heights in female athletes Katie A Ewing, Hossein Mokhtarzadeh, Ina Janssen, Nicholas A Brown, Peter V Lee Poster No. 1880 Robot Validation of a Specimen Specific Numerical Human Knee Model that Predicts Both Kinematics and Laxity Eik Siggelkow, Iris Sauerberg, Francesco Benazzo, Marc BandiMuenchinger Posters Poster No. 1870 Open Surgical Dislocation for Hip Preservation Surgery in Adolescents: Outcomes from a Tertiary Pediatric Hip Center Harish S Hosalkar, James D Bomar Poster No. 1881 Implementation of a Gait Cycle in a 3D Fibril Reinforced Finite Element Model of a Knee Joint Mika E Mononen, Jukka S Jurvelin, Rami K Korhonen Poster No. 1882 A Motion Analysis Framework for Non-Invasive In-Vivo Evaluation of Knee Joint Performance Lennart Scheys, Pius Wong, Barbara Callewaert, Joerg Leffler, Alois Franz, Hilde Vandenneucker, Luc Labey, Alberto Leardini, Kaat Desloovere Poster No. 1883 Symmetry in Kinetics Variables in Total Hip Arthroplasty Patients during Unilateral vs. Bilateral Tasks Daniel Varin, Mario Lamontagne, Sarah Reynolds, Paul Beaulé Poster No. 1884 Hip Function after Total Hip Arthroplasty: Surgical Approach versus Reconstruction Parameters Mario Lamontagne, Daniel Varin, Stephanie Nowak, Paul Beaulé Poster No. 1885 An Instrumented Treadmill enables measurement of gait at high speeds, suggesting hip resurfacing almost matches normal controls, while hip replacement does not Anatole Wiik, Sara Tankard, Rachel Carten, Angus Lewis, Andrew A Amis, Justin Cobb Poster No. 1886 Transtibial Amputee Prolonged-Gait Characteristics Assessed Using an Intelligent Prosthetic Endoskeletal Component System-iPecsTM Dimitrios Kikidis, Dimitrios Tsiokos, George Papaioannou Poster No. 1887 Fitness to Return to Driving after Lower Limb Functional Impairment: Determining Peak Braking Ability in the Healthy Cohort and Standardizing Measurement Methods Aranghan Lingham, Ian McCarthy, Simon Grange, James R Lewis, Peter Smitham Poster No. 1888 Fitness to Return to Driving after Lower Limb Functional Impairment: Determining Minimum Braking Abilities Required to Perform an Emergency Stop Aranghan Lingham, Ian McCarthy, Simon Grange, James R Lewis, Peter Smitham Poster No. 1889 Differences in Posture and Segment Movements in Gait of Knee OA Patients and Matched Controls Katherine A Boyer, Peter A Federolf, Thomas P Andriacchi 147 Posters Poster No. 1890 Knee Kinematics and Kinetics during Step up and down in Patients with Knee Osteoarthritis Yasuaki Saho, Takuma Hoshiba, Noritaka Kawashima, Toru Ogata, Masami Akai, Toru Fukubayashi Poster No. 1891 Some Individuals with Knee Arthritis Prefer Elevated Heel Shoes Fred Nelson, Ralph Zade Poster No. 1892 Objective and Subjective Outcome Measures for the Surgical Treatment of Proximal Hamstring Avulsion Injuries Jonathan H Rylander, Don Heitman, Sean Scanlan, Michael Dillingham, Thomas Andriacchi PS2 Foot and Ankle Poster No. 1893 Biomechanical Pullout Strength of Medial Malleolar Screw Fixation Joseph M Schwab, Mei Wang, Kenneth Lin, Linda M McGrady, Gregory J Schmeling Poster No. 1894 Comparison of Transfer Sites for Flexor Digitorum Longus in Treatment of Posterior Tibialis Tendon Dysfunction Nicholas J Vaudreuil, William R Ledoux, Grant Roush, Eric Whittaker, Bruce Sangeorzan Poster No. 1895 Biomechanical Comparison of the Achillon vs. the Percutaneous Achilles Repair System (PARS) for Achilles Tendon Repair Constantine Demetracopoulos, Elizabeth Young, Susannah Gilbert, Jonathan T Deland Poster No. 1896 Comparison of Achilles Tendon Suture Repair Techniques: Krackow vs. Modified Mason-Allen Under Cyclic Loading in an In-Vitro Bovine Model Jong Kim, Roy Rusly, Kara Fruscello, Thierry Bacro, William Barfield, William McKibbin, John D DesJardins Poster No. 1897 Plantar Forces in Flexor Hallucis Longus vs. Flexor Digitorum Longus Transfer in Adult Acquired Flatfoot Deformity John M Arnold, Edward M Spratley, John R Owen, Chris D Glezos, Robert S Adelaar, Jennifer S Wayne PS2 Infection and Inflammation Poster No. 1902 Persistence of Bacterial DNA in Orthopaedic Infections Catherine Ambrose, Justin Miranda, Gloria R Gogola, Karen Gomez, Heidi Kaplan Poster No. 1903 Atsttrin β, an Engineered Protein Derived from Progranulin Growth Factor, binds to TNF receptors and exhibits potent anti-inflammatory activity in mice Yunpeng Zhao, Qingyun Tian, Haicheng Song, Fanhua Wei, Chuanju Liu Poster No. 1904 Arthritic Flare in TNF-Transgenic Mice is Caused by B-cell Clogging of the Draining Lymphatic Vessels and is Ameliorated by Anti-CD20 Therapy Jie Li, Edward M Schwarz Poster No. 1905 Persistent low-grade inflammation and degenerative tendon changes parallel grip strength declines in rats performing a moderate demand repetitive task for 18 weeks Helen Gao, Alex G Lambi, Paul W Fisher, Mamta Amin, Ann E Barr, Mary F Barbe Poster No. 1906 Constitutive activity of Nuclear Factor of Activated T Cells (NFAT) facilitates LPS-induced mRNA elongation of TNF in Monocyte/ Macrophage-lineage cells Hiroshi Minematsu, Mike J Shin, Ayse B Celil-Aydemir, Kyung-Ok Kim, Saqib A Nizami, Francis Y Lee Poster No. 1907 Effects of Tick Saliva on Musculoskeletal Inflammatory Molecules Richard Smith, Brittany Chavez, Kaylea Brewer, Nina Poole, Lewis Coons, Judy Cole Poster No. 1908 PGE2 Exerts Biphasic Effects on Human Tendon Stem Cells Jianying Zhang, James H Wang Poster No. 1898 Patient Specific Computational Modeling of Adult Acquired Flatfoot Deformity Edward M Spratley, Erika Matheis, Robert S Adelaar, Curtis W Hayes, Jennifer S Wayne Poster No. 1909 Thrombin Enhances the Production of Monocyte Chemoattractant Protein-2 in Human Osteoblast Cells via PAR1, PKC-delta c-Src Dependent Pathway Chun-Yin Huang, Hsiao-Chi TSAI, Chih-Hsin Tang Poster No. 1899 Pathogenic Mechanism of Acquired Flatfoot -Influence of Obesity Yuichi Takata, Tomoaki Kamiya, Kota Watanabe, Daisuke Suzuki, Mineko Fujimiya, Toshihiko Yamashita, Eiichi Uchiyama Poster No. 1910 Risk factors for radiographic progression in Japanese rheumatoid arthritis patients in the first five years from onset of disease: results from the IORRA cohort Taku Suzuki, Katsunori Ikari, Koichiro Yano, Eisuke Inoue, So Tsukahara, Kazumasa Nishimoto, Takuji Iwamoto, Yoshiaki Toyama, Atsuo Taniguchi, Hisashi Yamanaka, Shigeki Momohara Poster No. 1900 The shear mechanical properties of diabetic and non-diabetic plantar soft tissue William R Ledoux, Shruti Pai 148 Poster No. 1901 In Vivo Kinematics of Three-Component Mobile-Bearing Total Ankle Arthroplasty. A 3D-Evaluation Using Fluoroscopic Imaging Keiji Iwamoto, Tetsuya Tomita, Takaharu Yamazaki, Takahiko Fukumoto, Norimasa Shimizu, Masahiro Kurita, Kazuma Futai, Yasuo Kunugiza, Kenrin Shi, Hideki Yoshikawa, Kazuomi Sugamoto Poster No. 1912 CD64 expression on eosinophil is useful for distinguishing drug fever from infection-related fever Narutaka Katoh, Chisato Kawabata, Yuko Hotta, Jinju Nishino, Keita Nishimura, Takashi Matsushita Poster No. 1913 Immunohistochemical assessment of subchondral bone after biological therapy in patients with rheumatoid arthritis Masamitsu Tomioka, Ken Kumagai, Yutaka Inaba, Yutaka Fujiwara, Kosuke Matsuo, Yohei Yukizawa, Yoshihiro Kusayama, Haruka Suzuki, Akiko Nagaoka, Mari Fujisaki, Tomoyuki Saito Poster No. 1914 Mixing Method Affects the Release and Compressive Strength of High Dose ALBC Ryan Miller, Alex McLaren, Christine Leon, Francis Calara, Ryan McLemore Poster No. 1915 The in vitro Antimicrobial Properties of nano-Magnesium oxide (nMgO) Duane A Robinson, Michael G Conzemius Poster No. 1916 Evaluation of Sterilization Methods Following Contamination of ACL Hamstring Autografts Xinning Li, Matthew Plante, Michael Brown, Brian Busconi, Nicola DeAngelis Poster No. 1917 M1 and M2 Macrophage Polarization in vitro with exposure to LPS and IL-4 Allison Rao, Emmanuel Gibon, Ting Ma, Zhenyu Yao, R Lane Smith, Stuart B Goodman Poster No. 1918 PLGA Encapsulating Antibiotic Loaded Titanium Prosthesis in Osteomyelitis Prevention in Rats Chien Te Lee, Chen Wei Lee, Chiung Wen Hu, Guo An Lai, Ming Long Yeh Poster No. 1919 Voriconazole Is Delivered From ALBC Ryan Miller, Alex McLaren, Christine Pauken, Henry Clarke, Ryan McLemore Poster No. 1920 Increased Controlled Release of Vancomycin From Injectable Degradable Hydrogels In Comparison To Acrylic Bone Cement Keith Jarbo, Derek Overstreet, Richard Huynh, Brent Vernon, Alex McLaren, Ryan McLemore PS2 Total Hip Replacement - Resurfacing and Metal on Metal Poster No. 1921 BMD changes the acetabulum, femoral neck and proximal femur following total and resurfacing hip arthroplasty. 2 year results from a RCT Jeannette O Penny, Ole Ovesen, Jens-Erik Varmarken, Kim Brixen, Soren Overgaard Posters Poster No. 1911 Oxidative Stress is more Associated with the Pathogenesis of Rheumatoid Arthritis than Osteoarthritis and Pseudogout Toshihide Fujii, Naoki Kondo, Takahiro Netsu, Keiichi Maniwa, Hiroshi Yamagiwa, Naoto Endo Poster No. 1922 Soft Tissue Role in Total Hip Arthroplasty Versus Femoral Head Resurfacing: A Robotic Model of Hip Dislocation Potential Robb Colbrunn, John Bottros, Tara F Bonner, Sam Butler, Antonie van den Bogert, Wael Barsoum Poster No. 1923 Cement Penetration into Femoral Head with Longitudinal Slot Following Hip Resurfacing Arthroplasty Scott Hazelwood, Scott Snyder, Amir Jamali Poster No. 1924 Optimized Cementing Technique for Birmingham Hip Resurfacing Arthroplasty Rudi G Bitsch, Johannes S Rieger, J. Philippe Kretzer, Sebastian Jaeger Poster No. 1925 A Comparison in Clinical Outcomes between Posterior and Anterolateral Approaches of Hip Resurfacing Yohei Yukizawa, Yutaka Inaba, Naomi Kobayashi, Kyohei Murakami, Takashi Ishida, Naoyuki Iwamoto, Hyonmin Choe, Hiroyuki Ike, Haruka Suzuki, Masamitsu Tomioka, Tomoyuki Saito Poster No. 1926 Migration Analysis of a Monoblock Resurfacing Acetabular Component for Hip Resurfacing. The fate of the unseated cup Paul Beaulé, Josh K Lee, Nima Soudi, Craig White, Jaime Lopez Casterallo, Paul Kim Poster No. 1927 Mal-positioning Alone Does Not Necessarily Lead to Increased Wear in Metal-on-Metal Hip Resurfacing Stephen J Mellon, Michael S Andersen, George Grammatopoulos, Harinderjit S Gill Poster No. 1928 Effect of Analysis Laboratory on Metal Levels After MoMHR and Potential Impact on Patient Management and Interpretation of Research Datasets Matthew Clark, Jennifer Prentice, Nigel Hoggard, Ian Stockley, Josh Jacobs, J. Mark Wilkinson Poster No. 1929 Spinal and Pelvic Motion after Hip Resurfacing Arthroplasty and Metal on Metal Total Hip Arthroplasty Eugene T Stone, P. C Noble, V. Kannan, D. Daylamani, U. Osadebe, A. Brekke, S. Incavo, K. B Mathis, R. Patel 149 Posters Poster No. 1930 Clinical Outcome, Metal Ions and Oxidative Stress Markers Comparison of 36mm, 40mm and 44mm Metal-on-Metal Total Hip Arthroplasty Nayla M Gosselin-Papadopoulos, Sarantis Abatzoglou, Laura M Epure, Alain Petit, Olga Huk, David J Zukor, John Antoniou Poster No. 1940 A Randomized Trial Comparing Bone Mass Density after Total Hip Arthroplasty with a Monoblock metal on metal acetabular component vs. a modular titantium Metal-on Polyethylene Paul Beaulé, Luke Gauthier, Paul Kim, Robert Feibel, Peter Thurston, Laurent Dinh Poster No. 1931 Friction coefficients of large diameter metal-on-metal hip arthroplasty couples are inversely proportional to diametric clearance Amir Kamali, H. S Gill, Joseph Pamu, S. J Mellon PS2 Total Knee Reconstruction General/Wear Poster No. 1932 Clinical Outcome and Metal Ion Levels in Patients with Ceramic on Metal versus Metal on Metal Bearings John Antoniou, Laura M Epure, Pierre Philippe Zaharia, Avishai Reuven, Olga Huk, David J Zukor Poster No. 1933 Geometric Wear Measurement of Metal-on-Metal Hip Replacements Tested Under Adverse In Vitro Simulator Conditions Mazen Al-Hajjar, Ling Wang, Sophie Williams, Joanne L Tipper, John Fisher, Louise M Jennings Poster No. 1934 Metal Ion Levels and Oxidative Stress Markers in Blood of Patients Following Articular Surface Replacement (ASR™): Three to Five Years of Follow-Up Abdallah Husseini, Laura M Epure, Alain Petit, Olga Huk, David J Zukor, John Antoniou Poster No. 1935 Systemic Health Effects of Chronic Metal Exposure after Metal-onMetal Hip Resurfacing Jennifer Prentice, Matthew Clark, Nigel Hoggard, Ian Stockley, Alison Morton, Claire Tooth, Marios Hadjivassiliou, J. Mark Wilkinson 150 Poster No. 1941 Medical costs, mortality and, downstream disease in osteoarthritis patients with and without Total Knee Arthroplasty Scott Lovald, Kevin Ong, Edmund Lau, Jordana Schmier, Steve Kurtz, Kevin Bozic, Javad Parvizi Poster No. 1942 Limitations of patient reported functional outcome following Total Knee Arthroplasty David Hamilton, Paul Gaston, Hamish Simpson Poster No. 1943 Biomechanical and Neuromuscular Changes after Total Knee Arthroplasty are Sex-Specific Janie L Astephen Wilson, Cheryl L Hubley-Kozey, Michael Dunbar Poster No. 1944 Relationship between Surface Roughness and Articular Wear for Cobalt-Chrome on Polyethylene Bearing Couples: Evaluation of Retrieved Unicondylar Knee Replacements Estefania Alvarez, John D DesJardins, Sabine Schmitt, Melinda K Harman Poster No. 1945 Malalignment: Can Thin Sequentially Cross-Linked Tibial Inserts Pass The Test? Laryssa A Korduba-Rodriguez, Siraj A Sayeed, Aaron Essner, Ronald E Delanois, Michael A Mont Poster No. 1936 An Investigation of Metal Ion Release in Total Hips, Hip Resurfacing and Total Knee Replacements Elie Khoury, Ronald M Gillies, Jenny Burke Poster No. 1946 Comparing the Kinematics of In Vitro Wear Simulations to Fluoroscopic Outcomes in Total Knee Replacement Matt Dressler, Filip Leszko, Sumesh M Zingde, Catherine Hardaker, Richard D Komistek Poster No. 1937 A Randomized Controlled Trial of a Cemented vs. Cementless Femoral Component for Metal-on-Metal Hip Resurfacing: A Bone Mineral Density Study Paul Beaulé, Paul Kim, Laurent Dinh Poster No. 1947 Prediction of Wear in Crosslinked Polyethylene Unicompartmental Knee Arthroplasty Darryl D D’Lima, Jonathan Netter, Juan Hermida, Cesar Flores, Nikolai Steklov, Clifford Colwell, Mark Kester Poster No. 1938 Changes in Blood Ion Levels after Removal of Metal-On-Metal Hip Replacements S. Durrani, B. Sampson, P. C Noble, T. Panetta, A. D Liddle, S. A Sabah, J. Skinner, A. J Hart Poster No. 1948 A Retrieval Analysis of Matched High Flexion and Posterior Stabilized Tibial Inserts Matthew Teeter, Nicholas Paterson, Steven MacDonald, Richard McCalden, Robert Bourne, Douglas Naudie Poster No. 1939 Lymphocyte Reactivity but Not Patch Testing, Flow Cytometry or Cytokine Analysis Correlates with Metal Ion Levels in Early Results (4yrs) of Patients with Metal-On-Metal Hip Arthroplasty Nadim J Hallab, Marco S Caicedo, Pat Campbell, Harlan Amstutz, Joshua J Jacobs Poster No. 1949 Development and Assessment of Knee Femoral Component Surface Damage Classification and Training Method Estefania Alvarez, Melinda K Harman, John D DesJardins Poster No. 1950 Volume Loss of Retrieved Tibial Inserts Correlates to Visual Damage Score Christopher B Knowlton, Michel P Laurent, Markus A Wimmer Poster No. 1951 Effects of Anti-Oxidation Treatments During the Manufacturing of Ultra High Molecular Weight Polyethylene Prosthetic Components on Their Osteolytic and Osteogenic Properties as Wear Debris Particles in a Murine Calvaria Model Justin M Green, Nadim J Hallab, Askim Senyurt, Yen-Shuo P Liao, Regis J O’Keefe, Edward M Schwarz, Chao Xie Poster No. 1952 M1 and M2 Macrophages, Wear Particles and Joint Replacement Allison Rao, Emmanuel Gibon, Ting Ma, Zhenyu Yao, R Lane Smith, Stuart B Goodman Poster No. 1953 Elevation of Metal Ions in the Blood of Rabbits Receiving Orthopaedic Materials Wear Debris in the Knee Joint Vivek Pawar, Stanley Tsai, Carolyn Weaver Poster No. 1954 The Effects of Polyethylene Particles at a Weight-Bearing Rat Tibia Bone-Implant Interface Kerellos Nasr, Nancy M Jackson, Basma M Khoury, Amanda O Esquivel, Weiping Ren, David Markel Poster No. 1955 Titanium-Alloy Particle Lymphocyte Reactivity is Associated with a Higher Degree of Lymphocyte Stimulation to Aluminum and Vanadium Ions Marco S Caicedo, Lauryn Samelko, Stacie Ott, Nadim J Hallab Poster No. 1956 Effective Particle Size not individual Particle Size Determines UHMWPE Inflammatory Reactivity In Vitro: Increasing Particle Agglomeration Decreases Bioreactivity Nadim J Hallab, Kyron McAllister, Anastasia A Hallab Poster No. 1957 Increasing Size and Surface Roughness of Co-alloy particles Induces increased Lysosomal Destabilization Resulting in more Inflammasome Activation (IL-1beta) and Inflammation Lauryn Samelko, Marco S Caicedo, Kyron McAllister, Nadim J Hallab Poster No. 1958 Selective inhibition of the MCP-1-CCR2 ligand-receptor axis decreases systemic trafficking of macrophages in the presence of UHMWPE particles Emmanuel Gibon, Ting Ma, Pei-Gen Ren, Kate Fritton, Sandip Biswal, Zhenyu Yao, Robert L Smith, Stuart B Goodman Poster No. 1959 Lymphocyte Reactivity to Implant Metals Correlates with Reported High Pain Levels in Patients with Total Joint Arthroplasties: Implications for Pain-Related Hypersensitivity Responses Marco S Caicedo, Lauryn Samelko, Stacy Ott, Nadim J Hallab Poster No. 1960 Phenotypic Differentiation of Primary Human Macrophages (M1 vs M2) indicates M1 Response to Cobalt-alloy Particles and M2 response to Particles with Endotoxin Seung-Jae Lim, Kyron McAllister, Joshua J Jacobs, Lauryn Samelko, Nadim J Hallab Posters PS2 Arthroplasty - Osteolysis Wear Debris Poster No. 1961 Increased expression of proinflammatory cytokines and suppression of Toll-like receptor (TLR)4 and their adaptor molecules in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles Tomoyuki Hirayama, Yasunobu Tamaki, Yuya Takakubo, Kan Sasaki, Kiyoshi Iwazaki, Yasushi Naganuma, Stuart B Goodman, Yrjö T Konttinen, Michiaki Takagi PS2 Arthroplasty - Implant Fixation Poster No. 1962 A vibrational technique to detect loosened hip implants - an experimental study Johannes S Rieger, Sebastian Jaeger, Christian Schuld, Rudi G Bitsch Poster No. 1963 Three-dimensional primary stability analysis of the cementless Fitmore® hip stem Jan Nadorf, Wojciech Pepke, Markus Streit, Jörn Reinders, Robert Sonntag, J.Philippe Kretzer Poster No. 1964 Standardized biomechanical testing materials - 2nd- vs. 4thgeneration synthetic femurs Jan Nadorf, Christian Heisel, Eike Jakubowitz, Robert Sonntag, Jörn Reinders, J.Philippe Kretzer Poster No. 1965 Measurement of Micromotion in Anatomical and Straight Femoral Stems Alexandre Terrier, Miguel Gortchacow, Michael Wettstein, Magdalena Müller-Gerbl, Dominique P Pioletti Poster No. 1966 The Effect of Geometry and Surface Condition on the Extraction Force of Cementless Femoral Pegs Shouchen Dun, David Wolfson, Kori Rivard Poster No. 1967 Nanomaterial-Coated Implants for Joint Replacement in Elderly Patients A. Dusad, D. Chakkalakal, F. Namavar, H. Haider, G. Thiele, B. Hanisch, M. Duryee, A. Diaz, A. Rensch, Y. Zhang, R. Hess, E. Fehringer Poster No. 1968 Topical Bisphosphonate Increases Fixation in the Bone-Cement Interface In Vivo Andreas West, Kasra Zainali, Jørgen Baas, Kjeld Søballe Poster No. 1969 Stimulation of Bone Healing in Sheep with a Reinforced Bone Substitute and Colloss®E Ming Ding, Jesper Røjskjær, Naseem Theilgaard, Søren Overgaard 151 Posters Poster No. 1970 Comparison of Osseointegration and Implant-Bone Interface Fixation in vivo Between Tissue-Engineered and Non Tissue-Engineered Constructs Elena Garcia, Jia Hua, Gordon W Blunn Poster No. 1981 Changes in Lower Extremity Three-Dimensional Load-Bearing Axes before and after Total Knee Arthroplasty: Comparison between Meniscal-Bearing and Rotating-Platform Design Yoshinori Ishii, Hideo Noguchi, Mitsuhiro Takeda, Junko Sato Poster No. 1971 Local Application of Alendronate Controls Bone Formation Induced by Bone Morphogenetic Protein-2 Seiichiro Kitasato, Takaaki Tanaka, Masaaki Chazono, Atsuhito Kakuta, Keishi Marumo Poster No. 1982 In vivo movement of femoral flexion axis of a single-radius total knee arthroplasty Norimasa Shimizu, Tetsuya Tomita, Takaharu Yamazaki, Keiji Iwamoto, Masahiro Kurita, Kazuma Futai, Yasuo Kunugiza, Kazuomi Sugamoto Poster No. 1972 Interfacial Shear Strength of Bioactive Coated Carbon Fiber Reinforced Polyetheretherketone After In Vivo Implantation Ichiro Nakahara, Masaki Takao, Shunichi Bandoh, Shigeru Hibino, Takashi Sakai, Takashi Nishii, Nobuhiko Sugano Poster No. 1983 The Extension Gap Becomes Tight and Valgus After Implantation of Mobile-bearing Total Knee Prosthesis Yukihide Minoda, Shigeru Nakagawa, Yoshinori Kadoya, Akio Kobayashi, Hidekazu Tomari, Makoto Kondo, Hiroyoshi Iwaki, Mitsuhiko Ikebuchi, Taku Yoshida, Yoshio Matsui, Akira Sumitomo, Ryo Sugama, Shigekazu Mizokawa, Yasuo Higuma, Takahiro Noguchi, Masashi Hirakawa, Hiroaki Nakamura Poster No. 1973 Dip-coating with a Modular Pro-Osteogenic Peptide Promotes Healing of a Bone-Implant Gap in an Ovine Model Yan Lu, Jae-Sung Lee, Brett Nemke, Ben K Graf, Richard Illgen III, Vanderby Ray, Kevin Royaly, Mark D Markel, William L Murphy Poster No. 1974 Pre-clinical development of a new osseointegrated fixation implant for amputated patients designed to reduce bone failure risk and periprosthetic bone loss Pawel K Tomaszewski, Nico Verdonschot, Mike van Diest, Bastien Lasnier, Sjoerd K Bulstra, Bart Verkerke Poster No. 1975 Evidence of Loss of Fixation Strength Following In Vivo Service with Cemented Total Knee Replacements Mark A Miller, Caitlin Pray, Kenneth Mann Poster No. 1976 Dynamic Fatigue Testing of Cement Mantle Integrity Around a Tibial Tray Gregg Schmidig, Mayur Thakore, Laura Yanoso-Scholl Poster No. 1977 The Effect of Fixation Design on Micromotion of Cementless Tibial Baseplates Vincent Alipit, Safia Bhimji PS2 Total Knee Replacement - Kinematics Poster No. 1978 Influence of Kinematics on the Wear Rate of the Artificial Patella Femoral Joint Raman Maiti, John Fisher, Zhongmin Jin, Liam Rowley, Louise M Jennings Poster No. 1979 Feature-Based Bi-Planar Registration for Kinematic Analysis of Total Knee Arthroplasty Shahram Amiri, Carolyn Anglin, Kenard Agbanlog, Bassam A Masri, David R Wilson Poster No. 1980 The Effect of Anatomical Variation on TKR Contact Forces during the Stance Phase of Gait Patrick Whelan, Markus A Wimmer, Hannah Lundberg 152 Poster No. 1984 The design of the total knee prosthesis changed the intra-operative joint gap Takahiro Noguchi, Makoto Kondo, Kazuhide Tomari, Yasuo Higuma, Shigeru Nakagawa, Yukihide Minoda, Msashi Hirakawa Poster No. 1985 Validation of a MRI Based Protocol to Measure Knee Alignment Angles for use in Total Knee Arthroplasty Jerry D’Alessio, Mayur Thakore, Michael Santarella, Kyle Kuznik, Oleg Mishin, Rama Ramakrishnan, Kevin Song, Amisha Patel, Mohammed Soliman Poster No. 1986 TKA Fingerprinting: Patellar tendon wrapping during joint line elevation Nicholas Dunbar, Silvia Pianigiani, Bernardo Innocenti, Luc Labey, Scott A Banks Poster No. 1987 In Vivo Kinematics of Bi-Surface Total Knee System Shinichiro Nakamura, Takashi Nakamura, Masahiko Kobayashi, Hiromu Ito, Noboru Ikeda, Kenji Nakamura, Sumesh M Zingde, Richard D Komistek Poster No. 1988 Probabilistic Modeling of Femoral Component Overhang Pat Courtis, Mark Heldreth, David FitzPatrick Poster No. 1989 The effect of distal femoral bone cut on flexion gap in cruciate retaining total knee arthroplasty -A cadaveric study Masahiro Nozaki, Masaaki Kobayashi, Yuko Nagaya, Hideyuki Goto, Hirohito Mitsui, Hirhito Iguchi, Nobuyuki Watanabe, Takanobu Otsuka Poster No. 1990 Management of MCL Tension in Deep Flexion: Influence of Implant Shape Chadd W Clary, Joe G Wyss, Abe P Wright, Travis D Bennett, Daniel D Auger, Mark A Heldreth Poster No. 1992 Complete gap control in total knee arthroplasty: component gap estimation before final bone resection of the femur Ryutaku Kaneyama, Hideaki Shiratsuchi, Kazuhiro Oinuma, Youko Miura Poster No. 1993 Posterior Cruciate Mechanoreceptor Comparison in Osteoarthritic and CR TKA Retrievals William M Mihalko, Kelly Zhang Poster No. 1994 Mobile-bearing Total Knee Prostheses Reduce Axial Rotational Constraint Torque Shouchen Dun Poster No. 1995 The effect of the remaining cartilage of the posterior condyle for femoral component rotational alignment in total knee arthroplasty Daisuke Hamada, Hiroshi Mikami, Hitoshi Goto, Tomoya Takasago, Tomohiro Goto, Koichi Oba, Hideaki Miyoshi, Hiroshi Egawa, Natsuo Yasui Poster No. 1996 Effect of Medial and Lateral Posterior Condylar Offset on Knee Flexion after Mobile-bearing Total Knee Arthroplasty Yoshinori Ishii, Hideo Noguchi, Mitsuhiro Takeda, Junko Sato Poster No. 1997 Improving Tibial Preparation in TKR Through Computerized Bioskills Training S. K Ismaily, L. Turns, J. Gold, D. Stal, A. Brekke, J. Alexander, K. B Mathis, P. C Noble Poster No. 1998 TKR Contact Forces for Normal and Abnormal Gait Patterns Hannah Lundberg, Kharma Foucher, Thomas Andriacchi, Markus A Wimmer Poster No. 1999 Material and Clinical Performance of Remelted Highly Crosslinked Polyethylene Used in Total Knee Arthroplasty Daniel MacDonald, Genymphas B Higgs, Javad Parvizi, Gregg Klein, Mark Hartzband, Harlan Levine, Matthew Kraay, Clare Rimnac, Steven M Kurtz Poster No. 2000 Reliability of TT-TG measurements - standardizing the frame of reference Simon J Harris, Justin P Cobb Poster No. 2001 In Vivo Determination of Cam-Post Engagement in PS, BCS and BiSurface TKA Sumesh M Zingde, Filip Leszko, Shinichiro Nakamura, John Mueller, Mohamed Mahfouz, Douglas Dennis, Richard D Komistek Poster No. 2002 Femoral Intercondylar Notch Resection Volume for Posterior Stabilized Knee Arthroplasty - Effects of Implant Alignment and Design Bo Gao, Laurent D Angibaud, Joe D Lipman, Michael Mauldin Poster No. 2003 Intraoperative measurement of Femoral anterior tangent (FAT) line for determining rotational alignment of the femoral component in Total knee arthroplasty Hiroki Watanabe, Ryuichi Gejo, Ayano Tokunaga, Norikazu Hirano, Tomoatsu Kimura Posters Poster No. 1991 The Medial Wall of the Intercondylar Notch is Useful for Tibial Rotational Reference in Unicompartmental Knee Arthroplasty Shinya Kawahara, Shuichi Matsuda, Ken Okazaki, Yasutaka Tashiro, Hiroyuki Nakahara, Shigetoshi Okamoto, Kazutaka Nishikawa, Yukihide Iwamoto Poster No. 2004 The Effect of the Characteristics of Soft Tissue in Cases When a Balanced Gap Technique is Used in a Posterior-Stabilized Total Knee Arthroplasty Hitoshi Nochi, Satomi Abe, Takuya Ruike, Yuusuke Sasaki, Takeo Matsuno PS2 Arthroplasty - Finite Element Analysis Hip Poster No. 2005 The Influence of Head Diameter and Wall Thickness on Deformations of Press-fit Cups and UHMWPE Liners Paul Goebel, Daniel Kluess, Jan Wieding, Robert Souffrant, Horst Heyer, Manuela Sander, Rainer Bader Poster No. 2006 Computational Fracture Analysis of Ceramic-on-Ceramic Total Hip Liners Jacob Elkins, Xiangyi Liu, Douglas Pedersen, John J Callaghan, Thomas Brown Poster No. 2007 Bone Ingrowth Surface Region Influences Remodeling Around a Noncemented Hip Resurfacing Implant Andrew D Speirs, Tim Elgin, Ifaz T Haider, Hanspeter Frei Poster No. 2008 Edge-Scraping Wear in Metal-on-Metal Total Hips Jacob Elkins, Douglas Pedersen, John Callaghan, Thomas Brown Poster No. 2009 Toward Optimizing Orientation in Metal-on-Metal Total Hips: Balancing Competing Considerations Jacob Elkins, Douglas R Pedersen, John J Callaghan, Thomas Brown Poster No. 2010 The Influence of Cement Modulus on the Fatigue Performance of Hip Implants Tested to ISO and ASTM Standards Leona E Morton, David S Simpson, Simon N Collins Poster No. 2011 Deformation of Press-Fit Metal Acetabular Components following Impaction into Physiologically Relevant Models Harry Hothi, James Busfield, Julia Shelton Poster No. 2012 WITHDRAWN 153 Posters Poster No. 2013 A Patient Specific Finite Element Model of the Residual BoneStump-Socket Interaction Validated with High Accuracy Dynamic Radiography Kinematics George Papaioannou, Ilya Avdeev, George Nianios, Christos Mitrogiannis Poster No. 2014 Validity of Local Coordinate Systems Embedded to the Distal Femur and Proximal Tibia Futoshi Ikuta, Kei Yoneta, Kazuyoshi Gamada PS2 Polyethylene Wear - UHMWPE Poster No. 2015 Wear Evaluation of Sequentially Crosslinked UHMWPE when subjected to Metal Debris Jason A Longaray, Lizeth Herrera, Reginald Lee, Aiguo Wang, Aaron Essner Poster No. 2016 Cross Linked Polyethylene in THA over 10 years: Wear, Activity and Aging Jeffrey Hopkins, Andrew Battenberg, Andrew Kupiec, Thomas Schmalzried Poster No. 2017 Wear of Highly Cross-linked Polyethylene is not influenced by Material of Femoral Head in THA Taishi Sato, Yasuharu Nakashima, Takuaki Yamamoto, Taro Mawatari, Takashi Itokawa, Masanobu Oishi, Goro Motomura, Mio Akiyama, Masanobu Hirata, Yukihide Iwamoto Poster No. 2018 A Clinically Relevant In Vitro Aging Model for Polyethylene Joints Mitchell Fung, Ebru Oral, Orhun K Muratoglu Poster No. 2019 Accelerated Aging of Highly Cross-linked UHMWPE after In Vivo Service Shannon Rowell, Orhun K Muratoglu Poster No. 2020 In Vivo Wear Particles of Annealed Highly Cross-Linked Polyethylene in Total Hip Arthropalsty Kanako Hata, Yukihide Minoda, Hiroyoshi Iwaki, Mitsuhiko Ikebuchi, Taku Yoshida, Nobuyuki Miyazaki, Yusuke Miyake, Hiroaki Nakamura Poster No. 2021 In Vivo Wear Particles of Remelted Highly Cross-Linked Polyethylene in Total Hip Arthropalsty Yukihide Minoda, Kanako Hata, Hiroyoshi Iwaki, Mitsuhiko Ikebuchi, Taku Yoshida, Nobuyuki Miyazaki, Yusuke Miyake, Hiroaki Nakamura Poster No. 2022 Do Large Diameter Femoral Heads and Ceramic Bearing Surfaces Impact the Revision and Wear of HXLPE? Steven M Kurtz, Dan W MacDonald, Javad Parvizi, Gregg Klein, Mark Hartzband, Gwo-Chin Lee, Amanda Marshall, Michael Mont, Harlan Levine, Matthew Kraay, Bernie Stulberg, Clare Rimnac 154 Poster No. 2023 Multi-center Minimum 5-year Wear Analysis of Large Femoral Heads on Highly-Crosslinked Polyethylene Charles R Bragdon, Micheal Doerner, John Martell, Young-Min Kwon, Paul F Lachiewicz, Kim Bertin, Henrik Malchau Poster No. 2024 Material Performance and Reasons for Revision of 1st and 2nd Generation Highly Crosslinked Polyethylenes Used in Total Hip Arthroplasty Steven M Kurtz, Daniel MacDonald, Javad Parvizi, Gregg Klein, Mark Hartzband, Gwo-Chin Lee, Amanda Marshall, Michael Mont, Harlan Levine, Matthew Kraay, Bernie Stulberg, Clare Rimnac Poster No. 2025 Comparison of Kinematic Analysis between 28, 32, 36 mm Femoral Heads during Squatting after Total Hip Arthroplasty Junichiro Koyanagi, Takashi Sakai, Takaharu Yamazaki, Tetsu Watanabe, Keisuke Akiyama, Nobuhiko Sugano, Hideki Yoshikawa, Kazuomi Sugamoto Poster No. 2026 Minimum Ten Year Follow-Up of Highly Cross-linked Polyethylene Liners in Total Hip Arthroplasty Charles R Bragdon, Brian Jarrett, Micheal Doerner, Dennis Burke, Andrew Frieberg, Harry E Rubash, Henrik Malchau Poster No. 2027 Evaluation of oxidation in virgin UHMWPE knee components after retrieval and shelf aging Mark L Morrison Poster No. 2028 Correlation between anteversion of the cup, pelvic inclination angle and polyethylene wear after total hip arthroplasty Taro Tezuka, Yutaka Inaba, Naomi Kobayashi, Naoyuki Iwamoto, Takashi Ishida, Yohei Yukizawa, Choe Hyonmin, Hiroshi Fujimaki, Hiroyuki Ike, Yasuhide Hirata, Tomoyuki Saito Poster No. 2029 Do RSA measurements of acetabular cup stability and polyethylene wear improve by adding tantalum beads to the liner? Meridith Greene, Audrey K Nebergall, Henrik Palm, Charles R Bragdon, Henrik Malchau Poster No. 2030 The Effect of Squalene on Environmental Stress Cracking of Highly Crosslinked UHMWPE Zachary Konsin, Keith Wannomae, Orhun K Muratoglu PS2 Arthroplasty - Finite Element Anlysis Knee Poster No. 2031 How the distal femoral resection angle influences stresses in ceramic total knee components Daniel Kluess, Philipp Bergschmidt, Iris Muller, Wolfram Mittelmeier, Rainer Bader Poster No. 2032 Evaluating Knee Replacement Mechanics during ADL with PIDControlled Dynamic Finite Element Analysis Clare Fitzpatrick, Mark Baldwin, Chadd Clary, Lorin Maletsky, Paul Rullkoetter Poster No. 2043 Can a Dual-tapered Press-fit Stem be used in Cases with Severe Proximal Femoral Defects Sophia N Sangiorgio, Ashleen R Knutsen, Jeremy J Kalma, Edward Ebramzadeh, Benjamin C Bengs Poster No. 2034 The Influence of Design on TKR Mechanics during Activities of Daily Living Clare Fitzpatrick, Chadd W Clary, Paul Rullkoetter Poster No. 2044 Press-fit Stability of Cementless Acetabular Shells with Two and Three Dimensional Fixation Surfaces Lokesh Kumar Raja, Gregg Schmidig, Christopher Heffernan Poster No. 2034A The Influence of Bone Resection Depth on Tibial Loading Renee Rogge, Susumu Tokunaga, Scott Small, Michael E Berend, Merrill A Ritter Poster No. 2045 Intraoperative Fluoroscopy Optimizes Limb Length Discrepancy But Not Cup Position: A Comparison Of Anterior Supine And Posterolateral Approaches In Primary THA Philipp Leucht, Heather Huddleston, Michael Bellino, James Huddleston PS2 Total Hip Replacement Implant Poster No. 2046 Continuous Monitoring of the Migration of Cemented Cup Fixed with Impaction Bone Grafting with Different Bone/HA ratio Shunji Kishida, Satoshi Iida, Hirotsugu Ohashi, Tomoyuki Yamazawa, Yuji Tanabe Poster No. 2035 Head Diameter is Positively Correlated with Taper Corrosion in Retrieved Large Diameter Metal-on-Metal Total Hip Replacements Alister Hart, Adam Hexter, Ashley Matthies, Gordon Blunn, E. Kew, Johann Henckel, John Skinner Poster No. 2036 Head Size Affects Corrosion Behavior in Artificial Hip Joints Richard M Dyrkacz, Urs P Wyss, Jan M Brandt, Olanrewaju Ojo, Tom Turgeon Poster No. 2037 Enhanced Wear and Corrosion in Modular Tapers in Total Hip Replacement - An in-vitro biomechanical study Gordon W Blunn, Jay Meswania, Jia Hua Poster No. 2038 A Protocol to Measure the Wear of Large Head Metal-on-Metal Total Hip Replacement Head Neck Taper Junctions Richard J Underwood, Ritchie S Sayles, Philippa Cann Poster No. 2039 Evaluating the impedance response of Ti-6Al-4V alloys under fretting conditions Viswanathan Swaminathan, Jeremy L Gilbert Poster No. 2040 How many different types of femora are there in primary hip osteoarthritis? An Active Shape Modelling study Christian Merle, Wenzel Waldstein, Jennifer S Gregory, Simon R Goodyear, Richard M Aspden, Peter R Aldinger, David W Murray, Harinderjit S Gill Poster No. 2041 Variation in Contact Areas in the Proximal Femur Depending on Implant Design Alejandro Marquez, Ronak M Patel, S. David Stulberg Poster No. 2042 Short-Stem Cementless Femoral Prostheses: Effect of Length on Torsional Stability, Proximal Femoral Strain, and Bone Prosthesis Contact Douglas Robertson, Gulshan B Sharma, Patrick McMahon, Riyaz Jinnah, William J Maloney Posters Poster No. 2033 Dynamic Finite Element Knee Simulator for Evaluation of Knee Replacement Mechanics Mark Baldwin, Chadd Clary, Clare Fitzpatrick, James Deacy, Lorin Maletsky, Paul Rullkoetter PS2 Implant - Uni-Knee Replacement Poster No. 2047 Effect of Polyethylene Crosslinking And Bearing Design on Wear Of Unicompartmental Arthroplasty Darryl D D’Lima, Jonathan Netter, Juan Hermida, Nikolai Steklov, Cesar Flores, Clifford Colwell, Jerry D’Alessio, Mark Kester Poster No. 2048 Strain measurements of proximal tibial following unicompartmental knee arthroplasty Andy Yew, Siaw Meng Chou, Pak Lin Chin, Shi-Lu Chia, Ngai Nung Lo, Seng Jin Yeo Poster No. 2049 Tibial Component Overhang Greater than 2 mm Should Be Avoided in Unicompartmental Knee Replacements: An In Vitro Robotic Study Mohammad Atarod Pilambaraei, Ravindra Gudena, Jason R Werle, Nigel G Shrive, Cyril B Frank Poster No. 2050 Effect of Resection Depth on UKA Fixation Mahmut Tuncer, Justin Cobb, Ulrich Hansen, Andrew A Amis PS2 Arthroplasty Hip & Knee - Surgical Navigation and Robotics Poster No. 2051 Cup Placement Accuracy with Robot-Assisted Total Hip Arthroplasty Nicholas Dunbar, Douglas E Padgett, Jennifer A Jones, Michael Conditt, Scott A Banks Poster No. 2052 Imageless Navigation as a Learning Device for Hip Resurfacing Arthroplasty Zachary Morison, Michael Olsen, Emil Schemitsch 155 Posters Poster No. 2053 Effectiveness of THA image-free navigation system for the leg length and the offset correction Fumiaki Inori, Hirotsugu Ohashi Poster No. 2054 Use of a Tensor with a Navigation to Assess the Accuracy of the Soft- Tissue Balance in Total Knee Arthroplasty Hideo Kobayashi, Naoto Mitsugi, Naoya Taki, Yasushi Akamatsu, Masato Aratake, Hirohiko Ota, Taichi Ideno, Tomoyuki Saito Poster No. 2055 Impact of Reaming Depth on Establishing the Tibial Intramedullary Canal Axis Yifei Dai, Mary Wentorf, Giles Scuderi, Kim Bertin, Jeffrey E Bischoff Poster No. 2056 An Accelerometer Based, Hand-Held Navigation System: The Future of Computer Navigation in Total Knee Arthroplasty? Denis Nam, Michael B Cross, David J Mayman Poster No. 2057 The effects of preoperative digital three-dimensional planning on the accuracy of implant positioning in total knee arthroplasty Yuki Takeda, Yasuo Niki, Wataru Iwamoto, Akihiro Hakozaki, Hiroya Kanagawa, Eri Katsuyama, Hideo Matsumoto, Toshiro Otani, Hiroyuki Enomoto, Yoshiaki Toyama, Yasunori Suda Poster No. 2064 Direct relationship between chromium or cobalt blood levels and the percentage of peripheral CD14+CD16+ monocytes in patients with recalled MoM hip implants David Markel, Nancy M Jackson, Basma M Khoury, Jeffrey C Flynn, Weiping Ren Poster No. 2065 Cobalt and Chrome Concentration and Histological Appearance in the Postoperative Pseudotumor, and Elemental Analysis of Metal Debris-Like Deposit from the Metal on Metal Total Hip Prosthesis Tomoaki Yoshikawa, Toru Yamakawa, Matsumoto Mamoru, Joji Morikawa, Shigeto Nakazora, Satoshi Hosoi, Akihiro Sudo Poster No. 2066 Cobalt and Chromium Ion Level Analysis from Metal-on-Metal Hip Replacements Tested under Adverse In Vitro Conditions Mazen Al-Hajjar, Sophie Williams, Joanne L Tipper, John Fisher, Louise M Jennings PS2 Implant Wear - Vitamin E Polyethylene Poster No. 2067 Wear-Corrosion Synergism Influences the Performance of HighCarbon and Low-Carbon CoCrMo Mathew Mathew Thoppil, C. Nagelli, M. Laurent, Joshua J Jacobs, Markus Wimmer Poster No. 2058 Thermo-oxidation of Irradiated Vitamin E Blended Polyethylenes Mariá José Martínez, José Antonio Medel, Francisco Javier Medel, Orhun K Muratoglu, Ebru Oral Poster No. 2068 Corrosion Behavior of Solution-Annealed CoCrMo Alloy for Metal-onMetal (MoM) Hip Joint Application Pooja Panigrahi, Yifeng Liao, Mathew T Mathew, Chris Nagelli, Alfons Fischer, Markus Wimmer, Laurence D Marks Poster No. 2059 The role of Vitamin E and Hindered Amine Light Stabilizers in suppressing crosslinks in irradiated Polyethylene Hung Ngo, Julia Hufen, Rainer Walkenhorst, Anuj Bellare Poster No. 2069 Magnetic Resonance Imaging of Metal on Metal Hip Resurfacing Implants Hollis G Potter, Catherine L Hayter, Matthew F Koff, Parina Shah, Kevin M Koch, Edwin P Su Poster No. 2060 Radiation Cross-linked, High Temperature Melted Vitamin E blended UHMWPE is Stable against Oxidation Brinda Doshi, Jun Fu, Ebru Oral, Orhun K Muratoglu Poster No. 2061 High Temperature Melting of UHMWPE/Vitamin E Blends does not lead to Grafting/Cross-linking without Irradiation Brinda Doshi, Ebru Oral, Orhun K Muratoglu Poster No. 2062 Impingement Wear Testing of a Dual Mobility Hip LaQuawn Loving, Reginald Lee, Lizeth Herrera, Aaron Essner Poster No. 2063 Wear Comparison of a Two Modular Hip Bearings: Mobile vs. Fixed LaQuawn Loving, Lizeth Herrera, Aaron Essner 156 PS2 Implant Wear - Metal on Metal and Ceramic Bearings Poster No. 2070 Scaled Surrogate Hertzian Bearing Pairs for Contact and Wear Testing Anthony P Sanders, Rebecca M Brannon Poster No. 2071 The Characterization of Damage Modes in Retrieved Metal-on-Metal Hip Implants Kirsten E Stoner, Simon L Greenbaum, Stefan Kinkel, Timothy Wright, Douglas E Padgett Poster No. 2072 The Evaluation of Tribological Properties of CyborGel for Replacing Articular Cartilage Doruk Baykal, Jay Katta, Kevin Mansmann, Steven M Kurtz Poster No. 2073 Using Micro-CT to Determine the Wear of PEEK in Pin-on-Plate Testing G Daniel G Langohr, Matthew Teeter, David Holdsworth, John B Medley, Nupur Maheswari, Micky Agarwal Poster No. 2084 Cross-talk between Discs and Adjacent Bone, Implication for Vertebrogenic Pain Ellen Liebenberg, Alex Giampaoli, Jeffrey Lotz Poster No. 2075 Hip Simulator Wear Testing of Diffusion Hardened Oxidized Zirconium Modular Couples Amit Parikh, Patrick Hill, Jeff Sprague, Vivek Pawar Poster No. 2085 Changes in Blood Flow, Oxygen Tension, Action Potentials And Vascular Permeability Induced by Arterial Ischemia or Venous Congestion on the Lumbar Spinal Cord in Canine Model Shigeru Kobayashi, Masafumi Kubota, Tsuyoshi Miyazaki, Hisatoshi Baba Poster No. 2076 Modeling, Testing, and Analysis of Impulse Response of Femoral Head Reduction in Ceramic Hip Prostheses Deepika Kakarla, Anthony P Sanders, Stephanie Siskey, Kevin Ong, Nicoli Ames, Jorge Ochoa, Rebecca M Brannon Poster No. 2077 Hip Simulator Wear Testing of Diffusion Hardened Oxidized Zirconium Hard-on-Hard Bearings in the Presence of Third-body Debris Amit Parikh, Patrick Hill, Jeff Sprague, Vivek Pawar Poster No. 2078 Radiostereometric analysis of in vivo micromotion in a total shoulder replacement - Two-year pilot study Trevor C Gascoyne, Martin Petrak, Peter MacDonald, Sheila McRae, Jeff Leiter, Eric Bohm PS2 Spine Poster No. 2079 Analysis of Staphylococcus aureus vertebral osteomyelitis Comparison of methicillin resistant and sensitive strains Shinichi Inoue, Tokuhide Moriyama, Toshiya Tachibana, Fumiaki Okada, Keishi Maruo, Yutaka Horinouchi, Shinichi Yoshiya Poster No. 2080 Intraosseous Transcutaneous Amputation Prostheses vs Dental Implants: A Comparative Study of Keratinocyte and Gingival Epithelial Cell Adhesion In Vitro Catherine Pendegrass, Gareth Chen, Pooria Hosseini, Christina Fontaine, Gordon Blunn Poster No. 2081 Patient walking distance - a measuring instrument following posterior spinal decompression with spinous process osteotomy S. C Budhiti, Rohit Dhawan, Birender Balain, J. Trivedi, David C Jaffery Poster No. 2082 Anatomic Considerations of Entrapment of the Superior Cluneal Nerves as a Cause of Low Back Pain Hiroshi Kuniya, Yoichi Aota, Tomoyuki Saito, Hayato Terayama, Masahiro Itoh, Yoshinori Kamiya, Kengo Funakoshi Poster No. 2083 Involvement of the Back Muscle in Gait Disturbance of Elderly Patients with Sagittal Spinal Deformity Takeshi Nakamura, Hiroshi Ozawa, Koshi N Kishimoto, Toshimi Aizawa, Tomoaki Koakutsu, Akira Sekiguchi, Kohei Takahashi, Eiji Itoi Posters Poster No. 2074 Friction of a variety of Total Hip Replacements Joel N Weisenburger, Hani Haider, Malcolm G Naylor, David W Schroeder, Bruce F White, Anthony Unsworth, Kevin Garvin Poster No. 2086 Three-dimensionaThree-dimensional Visualization of Microvasculature using Synchrotron Radiation-based In-line Phase Contrast Imaging in Rat’s Spinal Cord HongBin Lu, TianDing Wu, JianZhong Hu, Lei Zeng Poster No. 2087 Experimental Syringo-Hydromyelia Induced by Adhesive Arachnoiditis in Rabbit Ultrastructural Changes by Cerebro-Spinal Fluid (CSF) Flow Disturbance and Syrinx Formation Shigeru Kobayashi Poster No. 2088 Accumulation of p62 promotes spinal cord neurodegeneration under chronic mechanical compression Fumito Tanabe, Kazunori Yone, Naoya Kawabata, Setsuro Komiya, Takao Setoguchi Poster No. 2089 Quantitative Assessment of Posterolateral Lumbar Spinal Fusion in the Rat using a Dynamic µCT Technique Tomonori Yamaguchi, Won C Bae, Nozomu Inoue, Rajeswari Pichika, Mary E Lenz, Gregory M Williams, Timothy A Moseley, Koichi Masuda Poster No. 2090 FTY720 Improves Functional Recovery after Spinal Cord Injury via Non-Immunomodulatory Actions Yusuke Norimatsu, Tsukasa Ohmori, Atsushi Kimura, Seiji Madoiwa, Jun Mimuro, Atsushi Seichi, Yutaka Yatomi, Yuichi Hoshino, Yoichi Sakata Poster No. 2091 Effect of Low-Energy Extracorporeal Spinal Shock Wave Therapy on Spinal Cord Injury Seiji Yamaya, Hiroshi Ozawa, Haruo Kanno, Akira Sekiguchi, Koshi N Kishimoto, Kenta Ito, Eiji Itoi Poster No. 2092 Systemic treatment of SUN13837, a novel small molecular compound mimicking the pharmacological actions of bFGF, enhances functional recovery after spinal cord injury in rats Shiro Imagama, Norihito Murayama, Ryoji Tauchi, Ito Zenya, Kei Ando, Kenichi Hirano, Akio Muramoto, Ryouko Ogino, Yoshiari Shimmyo, Taishuke Kadoshima, Mariko Kuroda, Naohiro Takemoto, Shinya Ueno, Yasuhiro Morita, Daichi Ijiri, Teruyoshi Inoue, Joe Gertner, Naoki Ishiguro Poster No. 2093 WITHDRAWN Poster No. 2094 The fate of transplanted bone marrow derived mesenchymal stem cells following spinal cord injury in rats; according to the transplantation methods Young-Hoon Kim, Kee-Yong Ha, Eun-Sun Kang 157 Posters Poster No. 2095 Mapping Severities of Primary Spinal Cord Injury due to Cervical Spine Dislocation in Rats Zhun Xu, Zhiping Huang, Xiuhua Wu, Jianting Chen, Qingan Zhu Poster No. 2096 ADAMTS-13 of the central nervous system is produced by glial cells and up-regulated after spinal cord injury Ryoji Tauchi, Shiro Imagama, Kenji Kadomatsu, Zenya Ito, Kei Ando, Kenichi Hirano, Akio Muramoto, Hiroki Matsui, Tomohiro Matsumoto, Naoki Ishiguro Poster No. 2106 Osmotic Loading Effects on Juvenile Intervertebral Disc Cell Biosynthesis is Dependent on Cell Type and TGF-β3 Grace D O’Connell, Isabella B Newman, Michael A Carapezza, Jill P Urban, Clark T Hung Poster No. 2097 The analysis of CD44 in spinal cord of ALS model mice Tomohiro Matsumoto, Shirou Imagama, Zenya Itoh, Kei Andou, Kenichi Hirano, Ryoji Tauchi, Akio Muramoto, Hiroki Matsui, Yoshikazu Kobayashi, Naoki Ishiguro Poster No. 2107 Combined Anti-Inflammatory and Anti-AGE Drug Treatments have a Protective Effect on Intervertebral Discs in Mice with Type 1 Diabetes Svenja Illien-Junger, Frabrizio Grosjean, Damien Laudier, Helen Vlassara, Herb B Sun, Gary Striker, James Iatridis Poster No. 2098 Hyaluronan Oligosaccharides Promote Functional Recovery after Spinal Cord Injury in Rats Norimitsu Wakao, Kenji Kadomatsu, Shiro Imagama, Kei Ando, Kenichi Hirano, Ryoji Tauchi, Akio Muramoto, Hiroki Matsui, Tomohiro Matsumoto, Naoki Ishiguro Poster No. 2108 3D Facet Joint Space Width Distribution: Comparison with Age, Level and Lower Back Pain Symptom Peter Simon, Alejandro A Espinoza Orías, Howard An, Gunnar B Andersson, Nozomu Inoue Poster No. 2099 The role of keratan sulfate in experimental autoimmune neuritis Hiroki Matsui, Tomohiro Ogomori, Takamitsu Natori, Shiro Imagama, Zenya Ito, Kei Ando, Kenichi Hirano, Ryoji Tauchi, Akio Muramoto, Tomohiro Matsumoto, Kenji Kadomatsu, Naoki Ishiguro Poster No. 2100 Internalisation of micron and nano-particles by cells of the dura mater Iraklis Papageorgiou, Joanne L Tipper, Richard M Hall, John Fisher, Eileen Ingham Poster No. 2101 Modulation of an in vitro tissue-specific microenvironment to facilitate nucleus pulposus tissue regeneration Ming Pei, Mark Shoukry, Jingting Li Poster No. 2102 Hyaluronic Acid Hydrogel enhances Neuronal Survival in Organotypic Spinal Cord Slice Cultures Nikos Schizas, Ramiro Rojas, Sujit Kootala, Brittmarie Andersson, Jons Hillborn, Nils P Hailer Poster No. 2103 Isolation of osteogenic cell populations from bone fragments harvested during lumbar spine fusion procedures Shawn P Grogan, Michael Hennessy, Xian Chen, Sujata Sovani, Darryl D D’Lima, Robert K Eastlack Poster No. 2104 Acid-Etched Titanium Alloy Surfaces Induce Stem Cell Osteogenesis and Create an Osteogenic and Angiogenic Environment Rene Olivares-Navarrete, Sharon L Hyzy, Rolando Gittens, David A Haithcock, Jennifer Schneider, Peter F Ullrich, Zvi Schwartz, Barbara D Boyan 158 Poster No. 2105 Biological Effects of Prosthetic Cobalt-Chromium Nanoparticles on Cells of the Dural Membrane Bharat Behl, Iraklis Papageorgiou, Christopher Brown, Richard Hall, Joanne L Tipper, John Fisher, Eileen Ingham Poster No. 2109 Can images of preserved bone be used to model the behaviour of fresh bone? Sarrawat Rehman, Philippa E Garner, Jean E Aaron, Ruth K Wilcox Poster No. 2110 Surgical Anatomy of Nuchal Ligament in the Lower Cervical Spine; Cadaver and Clinical Study Atsushi Ono, Takuya Numasawa, Kanichiro Wada, Yoshihito Yamasaki, Toshihiro Tanaka, Yoshikazu Tonosaki, Satoshi Toh Poster No. 2111 Analysis of the Neurocentral Junction in the Normal Infantile, Juvenile and Adolescent Spine Tom P Schlösser, Koen L Vincken, Hamid Attrach, Michiel M Janssen, Max A Viergever, René M Castelein Poster No. 2112 Cortical Shell Thickness and Curvature Approximation for Computational Assessment of Human Vertebrae Alison C Jones, Holly Thornton, Sarrawat Rehman, Ruth K Wilcox PS2 Spine Biomechanics Poster No. 2113 Posture and Motion Technique Modulate Interbody Forces in the Cervical Spine:Direct In Vivo Measurements Using a Force-Sensing Implant in the Goat Mary Beth M Grabowsky, Rebecca A Wachs, Cory W Helder, Andrew Dubin, Joseph C Glennon, Elizabeth Leimer, Keegan Cole, Richard Uhl, Eric H Ledet Poster No. 2114 Cervical Spine Helical Axes of Motion and Facet Joint Loading: A Cadaveric Biomechanics Study Hitesh Mehta, Arin Ellingson, David Nuckley Poster No. 2116 Cyclic Testing of a Growing Rod System for Scoliosis Reconstructions David Kaimrajh, Harry Shufflebarger, Guillaume Leger, Hassan Serhan, Edward Milne, Loren Latta Poster No. 2117 In Vivo Screw Forces in Posterior Dual-Rod Spinal Fusion Instrumentation for Scoliosis Correction Diana A Glaser, Russell Hui, Krishna Cidambi, Peter O Newton Poster No. 2118 Biomechanical Analysis of a Less Invasive Destabilization Procedure for Corrective Surgery in Adolescent Idiopathic Scoliosis Sophia N Sangiorgio, Sean L Borkowski, Richard E Bowen, Anthony Scaduto, Nathan Frost, Edward Ebramzadeh Poster No. 2119 Familial Idiopathic Scoliosis in Males: Localization to Chromosome 22q Nancy H Miller, Kandice Swindle, Shane Cook, Jeffrey Dunn, Cristina M Justice Poster No. 2126 Sublaminar wires made with Dyneema Purity® fiber for fusionless scoliosis correction Laura Voss, Rob Bogie, Arno Lataster, Paul Willems, Jacobus J Arts, Lodewijk W Van Rhijn, Tim J Welting Poster No. 2127 Does the magnitude of curvature influence physical activity in patients with idiopathic scoliosis? Corinna C Winter, Carolin Schmidt, Carsten Müller, Katharina Fuchs, Tobias Schulte, Viola Bullmann, Dieter Rosenbaum Poster No. 2128 Influence of the Intramedullary Stress Distribution on Pathogenesis of Cervical Spondylotic Myelopathy: Biomechanical Study Using a Finite Element Method Kohei Takahashi, Hiroshi Ozawa, Naoya Sakamoto, Yuka Minegishi, Masaaki Sato, Eiji Itoi Poster No. 2129 Alleviation of Klippel Feil Syndrome Related Fusion - A Finite Element Analysis Enoch Leung, Nesrin Sarigul-Klijn, Rolando Roberto Poster No. 2120 Corrective forces in rods during scoliosis treatment Remel A Salmingo, Shigeru Tadano, Kazuhiro Fujisaki, Yuichiro Abe, Manabu Ito Poster No. 2130 Post Cervical Laminectomy Fusion Decision over Rod Materials and Screw Placement: A Stability and Stress Analysis Using Finite Element Simulation Ya-Wen Kuo, Chia-Chieh Chang, Dar-Ming Lai, Shan-Chang Chueh, YuShi Weng, Te-Chun Liu, Szusien Chen, Jaw-Lin Wang Poster No. 2121 Correlation and Reproducibility of 2D and 3D Spinal Measurements in Experimentally Created Scoliosis Diana A Glaser, Joshua Doan, Vidyadhar Upasani, Christine L Farnsworth, Peter O Newton Poster No. 2131 Multilevel Cervical Laminectomy Increases Upper Segmental Motions but Decreases Lower Segmental Motions Ya-Wen Kuo, Chia-Chieh Chang, Szusien Chen, Dar-Ming Lai, ShanChang Chueh, Jaw-Lin Wang Poster No. 2122 Improved Rabbit Model of Scoliosis and Thoracic Insufficiency Syndrome Casey Olson, Michael Glotzbecker, Vahid Entezari, Hemal Mehta, Brian D Snyder Poster No. 2132 Comparison of the global convergence optimization and the follower load concept in estimation of physiological loads in the human lumbar spine Won Man Park, Shaobai Wang, Kirkham B Wood, Yoon Hyuk Kim, Guoan Li Poster No. 2123 Validation of EOS 3D Reconstruction Accuracy Against CT Diana A Glaser, Joshua Doan, Peter O Newton Poster No. 2124 Development of a New 3D Topographic Device for Monitoring Scoliosis Progression in Children XueCheng Liu, Channing Tassone, John Thometz, Roger Lyon, Carlos Marquez-Barrientos, Sergey Tarima, Paul Johnson, Chi Lim, Laura Paulsen Poster No. 2125 A Possible Role for Posteriorly Directed Shear Loads in the Etiology of Degenerative Scoliosis Jasper Homminga, Mechteld M Lehr, Michiel M A Janssen, Tom P C Schlosser, Bart J Verkerke, Rene Castelein Posters Poster No. 2115 Time-Dependent Behaviors of the Cervical Spinal Segment under Sustained Loading Mei Wang, Ashish Taneja, Arnav Agarwal, Linda McGrady, Raj D Rao Poster No. 2133 Optimal Position of Follower Load Path to Improve Spinal Stability and Muscle Coordination Kyungsoo Kim, Yoon Hyuk Kim Poster No. 2134 Semi-Automatic segmentation of the lumbar muscles and gender specific cross-sectional areas Nicholas Battaglia, Mohamed Mahfouz, Michael Johnson Poster No. 2135 Specimen-Specific Model for Kinematic Assessment of Cervical Facet Joints Robert Havey, Jeremy Goodsitt, Tejaswy Potluri, Sean Hannon, Braden McIntosh, Parmenion Tsitsopoulos, Frank Phillips, Leonard Voronov, Avinash Patwardhan 159 Posters Poster No. 2136 A Method for Quantifying In Vivo Kinematics of the Lumbar Spine for Differentiating Patients Exhibiting Low Back Pain Michael Johnson, Mohamed Mahfouz, Joseph S Cheng, Adrija Sharma, Christy Hagewood, Richard D Komistek Poster No. 2137 Mimicking the Mechanical Behavior of Intervertebral Disc Degeneration Jeremy Alsup, Rebecca A Fullwood, Anton E Bowden Poster No. 2138 Optimization of an Automated Mesh Morphing Algorithm for Lumbar Vertebrae J Quinn Campbell, Luming Liang, Andrzej Szymczak, Anthony J Petrella Poster No. 2139 Stepwise Development of a Finite Element Model of the Lumbar Spine Milind Rao, Dana Coombs, Randy Ching, Mike Bushelow, Peter J Laz, Paul Rullkoetter Poster No. 2140 Influence of Various Experimental Conditions in Standard Test Protocols on In Vivo Compressive Stiffness of Spinal Cages by Finite Element Analysis Yoon Hyuk Kim, Dae Kyung Choi, Kyungsoo Kim Poster No. 2141 Influence of Endplate Morphology on Biomechanical Behavior in Double-Layer Endplates Aaron J Fields, Francisco Sahli, Azucena G Rodriguez, Jorge Ramos, Tony M Keaveny, Jeffrey C Lotz Poster No. 2142 Biomechanical Implications of Spinal Ligament Transection Gregory Von Forell, Anton E Bowden Poster No. 2143 Transforaminal Lumbar Interbody Fusion: Which Construct Configuration Provides the Optimal Biomechanical Stability? Divya V Ambati, Anton E Dmitriev, Ronald A Lehman Poster No. 2144 Comparing the Biomechanics of an Expandable Interbody Fusion Device versus Traditional Cage Designs Ali Kiapour, Ata Kiapour, Manoj Kodigudla, Sourbah Mishra, Vijay K Goel Poster No. 2145 Effect of Interbody Cage’s Footprint on the Endplate Stresses Immediately after TLIF Surgery: A Finite Element Based Study Faizan Ahmad, Ali Kiapour, Ata Kiapour, Vijay K Goel Poster No. 2146 Biomechanical Assessment of a Polyaxial Interspinous Plating System as an Adjunct to Interbody Fusion Leonard Voronov, Parmenion Tsitsopoulos, Robert Havey, Tejaswy Potluri, Julia Zelenakova, Gerard Carandang, Nikhil Kulkarni, Doug Schmierer, Mark Yap, Avinash Patwardhan 160 Poster No. 2147 The Effect of Posterior Spinal Instrumentation on the Stability of Inter-Body Fusion Cages under Cyclic Loading Robert Adamson, Ron N Alkalay, Michael Groff, Fred C Lam Poster No. 2148 Modified Compressive-Shearing Test for Determining Contact Behaviors of PE Component in Lumbar TDR - Advantage of the Concave PE Articulating Surface Wen-Chuan Chen, Hsiang-Ho Chen, Chang-Hung Huang, Kun-Jhih Lin, Yu-Liang Liu, Tsung-Wei Chang, Cheng-Kung Cheng Poster No. 2149 Diagnostic Parameters that Predict Spinal Shear Strength and Stiffness following Lumbar Laminectomy: A Human Cadaver Study Arno Bisschop, Barend J van Royen, Margriet G Mullender, Cornelis P Paul, Albert J van der Veen, Timothy U Jiya, Idsart Kingma, Jaap H van Dieën Poster No. 2150 Point Impedance Methods to Evaluate Spinal Stability After Dynamic Stabilization Surgery Michael Liebschner, Kwonsoo Chun, Inchul Yang, Bruce Ehni, Daniel Kim Poster No. 2151 Range of Motion of Lumbar Pedicle Screw Entrance Point Under PhysiologicalWeight Bearing Jianqiang Bai, Jun Miao, Qun Xia Poster No. 2152 Bone Mineral Density and Disc Degeneration influence Torsion Strength and Stiffness of the Human Lumbar Spine following Laminectomy Arno Bisschop, Jaap H van Dieën, Margriet G Mullender, Cornelis P Paul, Albert J van der Veen, Timothy U Jiya, Idsart Kingma, Barend J van Royen Poster No. 2153 Does tapping prior to bioactive cement augmentation of pedicle screws make a difference to screw stability in the osteoporotic spine? Ferris M Pfeiffer, Theodore Choma, Michael Reiter, Jesse Hirner Poster No. 2154 A Loose Constraint of Spinal Fixation May Be at The Risk of Intervertebral Foramen Stenosis Ying-Sian Chen, Chun-Ming Tu, Wan-Ju Lin, Wen-Kai Chou, Been Der Yang, Shan-Chang Chueh, Yu-Shi Weng, Jaw-Lin Wang Poster No. 2155 Biomechanical Analysis of Short Segment Fixation in an Unstable Thoracolumbar Flexion-Distraction Injury Model: 6-Screw Construct with and without Facet Compression Robert Norton, Edward Milne, David Kaimrajh, Seth Williams, Frank Eismont, Loren Latta Poster No. 2156 A Robot-Based System for Testing Rabbit Functional Spinal Units Robert A Hartman, Kevin M Bell, Yiguo Yan, James D Kang, Richard E Debski, Gwendolyn A Sowa Poster No. 2167 Change in Disc Material Property (from Grade II to Grade V) Has Larger Effect on Lumbar Disc Biomechanics Than Effect Due to Change in Disc Geometry Raghu Natarajan, Howard S An, Gunnar B Andersson Poster No. 2158 Calcium Triglyceride versus Polymethylmethacrylate Augmentation: A Biomechanical Analysis in Intact and Revision Models Lindsay E Hickerson, John R Owen, Jennifer S Wayne, H. R Tuten Poster No. 2168 Effect of Cartilage Endplate on Cell Based Disc Regeneration: A Finite Element Analysis Yongren Wu, Sarah Cisewski, Alaa Ahmad, Richard Gross, Hai Yao Posters Poster No. 2157 Correlations between mineral density and vertebral trabecular bone architecture of an ovariectomized rat Do-Gyoon Kim, Anand Navalgund, BoonChing Tee, Garrett J Noble, Richard T Hart, Hye Ri Lee PS2 Spine - Intervertebral Disc Biology PS2 Spine - Intervertebral Disc Biomechanics Poster No. 2159 In Vivo Administration of an Inflammatory Stimulant Can Trigger Loss of Biomechanical and Biochemical Properties of the Intervertebral Disc Nadeen Chahine, Ona Bloom, Neena Rajan, Nate Stetson, Daniel A Grande, Barbara Sherry, Mitchell Levine Poster No. 2160 Regional Variations in Sensitivity of Cells and Matrix to Mechanical Overloading of Lumbar Intervertebral Discs Cornelis P Paul, Magda de Graaf, Arno Bisschop, Albert J van der Veen, Theo H Smit, Marco N Helder, Barend J van Royen, Margriet G Mullender Poster No. 2161 The Involvement of RGD Integrins in the Response of Human Annulus Fibrosus Cells to Cyclic Tensile Strain: An Altered Mechanotransduction Pathway with Intervertbral Disc Degeneration Hamish T Gilbert, Judith Hoyland, Jane S Millward-Sadler Poster No. 2162 Intradiscal IGF-1 Administration May Not Improve Malnutrition in Intervertebral Disc Chun-Yuh C Huang, Wei Yong Gu Poster No. 2163 Effect of Dynamic Compression on ATP Production in Intervertebral Disc Chong Wang, Silvia Gonzales, Sebastian Verne, Wei Yong Gu, Chun-Yuh C Huang Poster No. 2164 Investigating the Mechanical Role of Cross-Bridging in the Annulus Fibrosus using Finite Element Analysis Bethany Luxmoore, Vithanage N Wijayathunga, Sarrawat Rehman, Kelly Wade, Samantha Rodrigues, Neil Broom, Ruth K Wilcox Poster No. 2165 Numerical Simulations Relate The Functional Direction-Dependence Of Fluid Flow Through The Vertebral Cartilage Endplate With Tissue Composition Gradients Jerome Noailly, Damien Lacroix Poster No. 2166 Repetitive Bending in Concert with Dynamic Compressive Loading in a Lumbar Motion Segment Lead to Decreased Number of Load Cycles to Failure Muhammad Qasim, Raghu Natarajan, Gunnar Andersson Poster No. 2169 Role of Shh and Sox9 during postnatal intervertebral disc growth and development Chitra L Dahia, Eric Mahoney, Christopher Wylie Poster No. 2170 Regulation of major cell signaling pathways by Shh in neonatal intervertebral disc Chitra L Dahia, Eric Mahoney, Christopher Wylie Poster No. 2171 TNF-α and IL-1β Promote ADAMTS-5 Mediated Aggrecan Degradation Through Transcriptional Upregulation of Syndecan-4 Jianru Wang, Dessislava Z Markova, David G Anderson, Zhaomin Zheng, Irving Shapiro, Makarand Risbud Poster No. 2172 Link-N Peptide: A Potential Agent for Biological Repair of Human Intervertebral Disc Rahul Gawri, Fackson Mwale, Jean Ouellet, Thomas Steffen, Peter Roughley, Lisbet Haglund, John Antoniou Poster No. 2173 TNFα exposure in an intervertebral disc organ culture model induces cellular senescence and persistent degenerative changes that do not recover following TNFα removal Ben Walter, Devina Purmessur, Peter J Roughley, Damien Laudier, Andrew C Hecht, James Iatridis Poster No. 2174 End Plate Transition from Cartilage to Bone in the Ageing Murine Intervertebral Disc: Role for BMP2 Esmeralda Blaney Davidson, Elly Vitters, Wim van den Berg, Peter M van der Kraan Poster No. 2175 Rapid decrease in Smad2/3 Signaling in the Annulus Fibrosus co-incides with loss of lamellar structure in the Ageing Murine Intervertebral Discs, while Smad1/58P stays stable until 16 months Esmeralda Blaney Davidson, Elly Vitters, Wim van den Berg, Peter van der Kraan Poster No. 2176 The Effect of Bone Morphogenetic Proten-7 under Low Osmotic Conditions As Seen in Degenerated Discs: The Rate of Glycosaminoglycan Accumulation by Disc Cells in Vitro Shigeru Kobayashi, Kenichi Takeno, Tsuyoshi Miyazaki, Adam Meir, Hisatoshi Baba 161 Posters Poster No. 2177 Age-related of MCP-1 and MMP-3 expression in intervertebral disc in relation to inflammatory cytokine stimulation Koji Fujita, Takashi Ando, Tetsuro Ohba, Masanori Wako, Ryohei Kato, Atuhito Nakao, Hirotaka Haro Poster No. 2178 Toll-Like Receptor 4 (TLR-4) Expression and Stimulation in an Inflammatory Model of the Intervertebral Disc Neena Rajan, Robert Mancino, Daniel A Grande, Ona Bloom, Nadeen Chahine Poster No. 2179 Inhibition of TLR adaptor signaling molecule, MyD88 on intervertebral disc homeostasis: in vitro, ex vivo studies Jae-sung Kim, Xin Li, Howard An, Jennifer An, Tejaswi Dittakavi, Gabriella Cs-Szabo, Steve An, Andre J van Wijnen, Hee-Jeong Im Poster No. 2180 Computational Pharmacokinetics of Antibiotics Transport in the Human Intervertebral Disc Saeed Shirazi-Adl, S. Motaghinasab, J. Urban, M. Parnianpour Poster No. 2181 The Autoimmunogenicity of Nucleus Pulposus Cells and Extracellular Matrix Stefan Dudli, Stephen J Ferguson, Daniel Haschtmann Poster No. 2182 Optimization of Percutaneous Needle Puncture to Induce Gradual Degeneration in the Intervertebral Disc of Rat Tail Ming-Hsiao Hu, Shu-Hua Yang, Yung-Chang Chen Poster No. 2183 Non-Notochordal Origin in Chondrocyte-like Cells of the Nucleus Pulposus Appearing in Early Stage Disc Degeneration in the Mouse Model Masahiro Tanaka, Daisuke Sakai, Akihiko Hiyama, Fumiyuki Arai, Daisuke Nakajima, Joji Mochida Poster No. 2184 Neonatal Exposure to High Dose Diethystilbesterol Affects Intervertebral Disc in Male and Female Adult Progeny Sora Al Rowas, Rahul Gawri, Abdul Aziz Almaawi, John Antoniou, Lorraine E Chalifour, Fackson Mwale Poster No. 2185 CHAD Fragmentation in Intervertebral Disc Degeneration Bashar Al Khatib, Richard Garfinkle, Rahul Gawri, Janet Moir, Peter Roughley, Jean Ouellet, Lisbet Haglund Poster No. 2186 The Degenerate IVD “Niche” and its Effect on the Discogenic Differentiation of Mesenchymal Stem Cells Francesca E Ludwinski, Stephen M Richardson, Judith Hoyland Poster No. 2187 Homing of IGF-1 transduced mesenchymal stem cells (MSCs) in degenerative intervertebral discs accelerates proteoglycan synthesis Girish Pattappa, Svenja Illien-Jünger, Marianna Peroglio, Martin J Stoddart, Lorin M Benneker, Daisuke Sakai, Joji Mochida, Sibylle Grad, Mauro Alini 162 Poster No. 2188 Proteoglycan metabolism modulation by small molecules for intervertebral disc regeneration Yi Sun, Victor Leung, Kiki Tusi, Koichi Masuda, Richard Kao, Danny Chan, Kenneth Cheung Poster No. 2189 Umbilical Cord Derived Mesenchymal Stem Cells Impose Better Paracrine Effect Than Bone Marrow Mesenchyma Stem Cells in Nucleus Pulposus Regeneration Fengjuan Lv, Yu-Leong Victor Leung, Guangqian Zhou, Kenneth M C Cheung Poster No. 2190 Optimizing Oxygen tension and Serum Concentration in ex vivo Culture of Mouse Nucleus Pulposus Cells Derived from the Notochord Daisuke Nakajima, Daisuke Sakai, Masahiro Tanaka, Katsuya Yokoyama, Tomoko Nakai, Joji Mochida Poster No. 2191 Interactions Between Mesenchymal Stem Cells and Nucleus Pulposus Cells: Implications for Intervertebral Disc Regeneration Shahnaz Khan, Stephen M Richardson, Judith Hoyland PS2 Spine - Spinal Therapeutics Poster No. 2192 Radiographic Measurement of Cervical Disc Height and the InterSurgeon Variability in its Application Hitesh Mehta, Edward R Santos, Jonathan Sembrano, Matthew Hunt, Ann Parr, David Polly, David Nuckley Poster No. 2193 Comparison of Natural Crosslinking Reagent and Platelet-Rich Plasma Therapy on Recovering Disc Dynamic Property - An Ex Vivo Study Using Whole Organ Culture System Yu-Chun Hsu, Ya-Ching Chang, I-Ting Chuang, Jian-Hong Lin, Ya-Wen Kuo, Mohammad Nikkhoo, Jaw-Lin Wang Poster No. 2194 Intradiscal Injection of Autologous Platelet-Rich-Plasma for the Treatment of Lumbar Disc Degeneration -Preliminary Prospective Clinical Trial for Discogenic Low Back Pain Patients Koji Akeda, Takao Imanishi, Kohshi Ohishi, Koichi Masuda, Atsumasa Uchida, Toshihiko Sakakibara, Yuichi Kasai, Akihiro Sudo Poster No. 2195 Glucosamine Supplementation Has a Negative Effect on Intervertebral Disc Matrix Lloydine J Jacobs, Joao P Coelho, Qing Dong, Bernard P Bechara, Eric Hempen, Nam Vo, James D Kang, Judith L Balk, Harry G Preuss, Gwendolyn A Sowa Poster No. 2196 The Effects of Trunk Stabilization Exercise for the Individuals with Chronic Low Back Pain - A Randomized Controlled Trial Takuya Miura, Masanori Yamanaka, Naoki Takeda Poster No. 2198 Augment® Bone Graft Products Compare Favorably to Autologous Bone Graft in an Ovine Model of Lumbar Interbody Spine Fusion Luis A Solchaga, Christopher K Hee, Dean J Aguiar, Jack Ratliff, A Simon Turner, Howard B Seim, Jeffrey O Hollinger, Leo B Snel, Samuel E Lynch Poster No. 2199 The Performance of a Sterile Demineralized Bone Matrix Putty in a Rabbit Posterolateral Fusion Model Amy Warren, Katrina Gonzales, Andrew Cotter, Thomas Sander Poster No. 2200 Evaluation of processed human amnion membrane to prevent postoperative adhesions in an ovine laminectomy model Adrian C Samaniego, Chad J Ronholdt, Stewart D Ryan, Ej Ehrhart, Simon A Turner, Howard B Seim, Simon Bogdansky, Brent L Atkinson PS2 Upper Extremity - Shoulder and Elbow Poster No. 2201 Effect of Bankart Lesion Combined with Rotator Cuff Tear on Glenohumeral Stability: A Biomechanical Study Sang-Jin Shin, Jae-Chul Yoo, Michelle McGarry, Bong-Jae Jun, Thay Q Lee Poster No. 2202 Quantitative analysis in angle and placement of the bone tunnel for suture anchor in arthroscopic Bankart repair Masahito Yoshida, Hidyuki Goto, Masahiro Nozaki, Yasuhiro Nishimori, Hirotaka Iguchi, Yasuhiro Banno, Takanobu Otsuka Poster No. 2203 A 3D Measure of Glenoid Version and Humerus Subuxation Alexandre Terrier, Xabier Larrea, Dominique P Pioletti, Alain Farron Poster No. 2204 Biomechanical Testing of Glenohumeral Stability in an Animal Model of Acute Anterior Shoulder Instability Mary K Mulcahey, Mindy A Cote, Stacey G Jaumot, Lee Kaback, Douglas Scott, Theodore A Blaine Poster No. 2205 Factors Expressed in the Glenoid Labrum in an Animal Model of Glenohumeral Instability Mary K Mulcahey, Mindy A Cote, Stacey G Jaumot, Lee Kaback, Theodore A Blaine Poster No. 2206 A Theoretical Model of the Effect of Bone Defects on Anterior Shoulder Instability Piyush Walia, Anthony Miniaci, Stephen D Fening Poster No. 2207 Does the Dynamic Sling Effect of the Latarjet Procedure Improve Shoulder Stability? A Biomechanical Evaluation Joshua W Giles, Harm W Boons, Kenneth Faber, Ilia Elkinson, Louis Ferreira, George Athwal, James Johnson Poster No. 2208 The Biomechanical Effectiveness of Classic and Congruent Arc Latarjet Procedures Joshua W Giles, Gabor Puskas, Mark Welsh, George Athwal, James Johnson Posters Poster No. 2197 A retrospective matched pair analysis on the long-term outcomes of the use of the DIAM inter-spinous spacer as an augment in single level unilateral Lumbar 4/5 decompression hemi-laminectomy for treatment of lumbar spinal stenosis Justin Boey, Benjamin Tow, Edwin Tan, William Yeo, Andy Yew, Wai Mun Yue, Chang Ming Guo, Seang Beng Tan Poster No. 2209 The Incidence of a Large Hill-Sachs Lesion Which Needs to Be Treated Daisuke Kurokawa, Nobuyuki Yamamoto, Yasushi Omori, Hirotaka Sano, Eiji Itoi Poster No. 2210 The Shoulder Remplissage Procedure for Hill-Sachs Lesions: Does Technique Matter? Joshua W Giles, Ilia Elkinson, Harm Boons, Kenneth Faber, Louis Ferreira, George Athwal, James Johnson Poster No. 2211 Percutaneous Balloon Humeroplasty for Hill-Sachs Lesions: A Novel Technique Rafal Stachowicz, James Romanowski, Robert Wissman, Keith Kenter Poster No. 2212 The Role of the Biceps Brachii in Overhead Throwing: A Biomechanical Study Michael Nguyen, Ryan Quigley, Michelle McGarry, Bryan Hanypsiak, Craig Morgan, Ranjan Gupta, Thay Q Lee Poster No. 2213 Automatic 2D-3D Image Matching Method for the Shoulder Joint Using Single or Dual Fluoroscopic Images Zhonglin Zhu, Daniel Massimini, Guangzhi Wang, Guoan Li Poster No. 2214 Evaluation of a Robotic Apparatus for the Analysis of Passive Glenohumeral Joint Kinematics Andreas M Mueller, Claudio Rosso, Brett McKenzie, Vahid Entezari, Joseph P DeAngelis, Arun J Ramappa, Ara Nazarian, Ugo M Della Croce Poster No. 2215 Design and Manufacture of A Novel System to Simulate the Real Time Biomechanics of Basic and Pitching Shoulder Motion using a Cadaveric Model Vahid Entezari, Benjamin L Trechsel, William A Dow, Stacey K Stanton, Claudio Rosso, Marc A Mueller, Brett McKenzie, Daniel Li, Vartan Vartanians, Joseph P DeAngelis, Arun J Ramappa, Ara Nazarian Poster No. 2216 Automatic and Manually Generated CT Models of the Glenohumeral Joint Produce Different Joint Kinematics Zachary F Merrill, Richard E Debski, Omar Jameel, Jon Sekiya 163 Posters Poster No. 2217 Coupled Scapulohumeral Motion During In-Vivo Dynamic Shoulder Abduction Daniel F Massimini, Zhonglin Zhu, Jon P Warner, Guoan Li Poster No. 2218 Relationships Between Glenoid Morphology And In-Vivo Glenohumeral Joint Motion Cathryn D Peltz, Jeffrey Haladik, Roger Zauel, Mike McDonald, Nicole Ramo, Patricia Kolowich, Terrence Lock, Vasilios Moutzouros, Michael J Bey Poster No. 2219 Scapular Position and Orientation In Symptomatic Throwing Shoulders: A Cross-Sectional Study Using 3D-TO-2D Registration Technique Masayuki Saka, Hiroki Yamauchi, Toru Yoshioka, Kazuyoshi Gamada Poster No. 2220 The Influence of Wrist Weight on the Humeral Rotation and the Scapular Posterior Tilting during Arm Elevation Yuji Takahashi, Hiroaki Tsutsui, Kazuhide Suzuki, Naoya Nishinaka, Takayuki Matsuhisa, Taishi Uehara, Keisuke Matsuki, Scott Banks Poster No. 2221 An Electromyography Analysis and Motion Analysis of the range of movement within a MRI scanner Anthony Howard, David H Hawkes, Omid Alizadehkhaiyat, Anthony Fisher, Graham Kemp, Bill Brimson, Dave Groves, Jim Richards, Simon P Frostick Poster No. 2222 Glenoid Version Measurement when the Medial Scapula Is Not in the Cross-Sectional Imaging Field of View Douglas D Robertson, Gulshan B Sharma, Melissa D Kang, David A Stone, Patrick J McMahon 164 Poster No. 2227 A Biomechanical Analysis of Long Head Biceps Tenodesis Techniques in the Bicipital Groove Lee Kaback, David J Paller, Andrew Green, Theodore A Blaine Poster No. 2228 Quantitative Assessment of Muscle Strength in Adult Brachial Plexus Reconstruction Yi-Jung Tsai, Yuan-Kun Tu, Chih-Kun Hsiao, Sheng-Wen Shih, Fong-Chin Su Poster No. 2229 A Novel Technique to Evaluate Coracoid Impingement: An MRI Study John S Blankenship, Saadiq F El-Amin, Matthew C Mai, Ryan T Beck Poster No. 2230 Degenerative Musculoskeletal Changes in Non-Human Primates Johannes F Plate, Christopher M Bates, Sandeep Mannava, Thomas L Smith, Katherine R Saul, Matthew J Jorgensen, Thomas C Register, Jay R Kaplan, Christopher J Tuohy Poster No. 2231 Elbow Helical Axes of Motion: A Comparison between an Elbow Simulator and a Robotic System Muturi Muriuki, Amin M Motlagh, Damian Davis, Patrick Smolinski, Mark Carl Miller Poster No. 2232 Axial Migration of the Radius through a Full Arc of Elbow Flexion/ Extension and Forearm Supination/Pronation Grant Robicheaux, Ryan Quigley, Michelle McGarry, Thay Q Lee Poster No. 2233 Three-Dimensional Specimen Specific Modeling Analysis of the Medial Collateral Ligaments of the Elbow William L Buford, Joris Snijders, Vikas Patel, Cody M Curry, Brian A Smith Poster No. 2223 The Effects of Arm Elevation on Acromiohumeral Distances: A Biplane Fluoroscopy Study with Normative Data J. Erik Giphart, Olivier van de Meijden, Peter Millett Poster No. 2234 The Influence of Shoulder Rotational Laxity on Elbow Joint Loading during Throwing Nigel Zheng, Hongsheng Wang, Koco Eaton Poster No. 2224 Effect of sectioning the Acromioclavicular and Coracoclavicular Ligaments in the Shoulder Complex Motion: A Whole Cadaver Study Satoshi Oki, Noboru Matsumura, Wataru Iwamoto, Hiroyasu Ikegami, Yoshimori Kiriyama, Toshiyasu Nakamura, Nobuaki Imanishi, Sadakazu Aiso, Yoshiaki Toyama, Takeo Nagura Poster No. 2235 Biomechanical Analysis of Pin Placement for Pediatric Supracondylar Humerus Fractures: Does starting point, pin size, and number matter? Diana A Glaser, Hilton P Gottschalk, Daljeet Sagoo, Joshua Doan, Eric W Edmonds, John Schlechter Poster No. 2225 Biomechanical Evaluation of Hole Diameter for Coracoclavicular Ligament Reconstruction on Coracoid Strength Sean Campbell, Mallika Tamboli, Jessica Hoeffner, Sang Jin Shin, Joel Murachovsky, Roberto Y Ikemoto, Luis G Nascimento, James E Tibone, Thay Q Lee Poster No. 2236 In Vivo 3-Dimensional Evaluation of Elbow Instability of Non-Union of the Lateral Humeral Condyle During Flexion-Extension Motion: Using 3D Images Matching Technique Akira Goto, Tsuyoshi Murase, Kunihiro Oka, Hisao Moritomo, Hideki Yoshikawa, Kazuomi Sugamoto Poster No. 2226 Locked Plating for Proximal Humerus Fractures: Do Long Subchondral Screws Provide a Significant Biomechanical Advantage Over Shorter Screws? Jason E Hsu, Eric T Ricchetti, David J Svach, Zhixu Guan, Joseph A Abboud, G. R Huffman Poster No. 2237 Effect of Radial Head Malunion on Radiocapitellar Stability Dave R Shukla, James S Fitzsimmons, Kai-Nan An, Shawn W O’Driscoll Poster No. 2239 Distal Biceps Tendon Rupture: An In Vitro Study Dave R Shukla, Bernard F Morrey, Andrew R Thoreson, Kai-Nan An, Shawn W O’Driscoll Poster No. 2240 Capitellum Surface Digitizations: Effects on Locating the Spherical Centre for Minimally Invasive Surgery Jennifer Ng, Emily Lalone, Colin McDonald, Louis Ferreira, Graham J King, James A Johnson Poster No. 2241 WITHDRAWN Poster No. 2242 Evaluation of Distal Forearm Fracture Risk Using HR-pQCT Imaging and Cohesive Finite Element Modeling Ani Ural, Bin Zhou, Xiutao Shi, Elizabeth Shane, X Edward Guo PS2 Upper Extremity - Hand and Wrist Poster No. 2243 Identifying the Mechanical Damage Limit of the Rabbit Subsynovial Connective Tissue Yutaka Morizaki, Matthias Vanhees, Andrew Thoreson, Dirk Larson, Chunfeng Zhao, Kai-Nan An, Peter Amadio Poster No. 2244 Diagnosing Autonomic Dysfunction in Carpal Tunnel Syndrome: Measuring Skin Capacitance Inji W Ibrahim, Wasim Khan, Sujay Dheerendra, Nicholas Goddard, Peter Smitham Poster No. 2245 Threshold for Mechanical Damage of the Subsynovial Connective Tissue within the Human Carpal Tunnel Matthias Vanhees, Yutaka Morizaki, Andrew Thoreson, Chunfeng Zhao, Kai-Nan An, Peter Amadio Poster No. 2246 Fibroblast-Specific Protein 1 is Increased in Subsynovial Connective Tissues in Idiopathic Carpal Tunnel Syndrome Takako Chikenji, Chunfeng Zhao, Anke Ettema, Yu-Long Sun, Masanori Hayashi, Kai-Nan An, Peter Amadio Poster No. 2247 Absence of Myofibroblasts in Subsynovial Connective Tissues in Human and Rabbit Models of Carpal Tunnel Syndrome Takako Chikenji, Matthias Vanhees, Tamami Moriya, Chunfeng Zhao, KaiNan An, Peter Amadio Poster No. 2248 The Effect of Time, after Shear Injury, on the Subsynovial Connective Tissue and Median Nerve within the Rabbit Carpal Tunnel Matthias Vanhees, Takako Chikenji, Andrew Thoreson, Chunfeng Zhao, James Schmelzer, Phillip Low, Kai-Nan An, Peter Amadio Poster No. 2249 Ultrasound Assessment of the Transverse Carpal Ligament Thickness: A Reliability and Validity Study Zhilei L Shen, Joshua L Gordon, John Cheng, Zong-Ming Li Poster No. 2250 Intrasynovial Flexor Tendon Repair: A Biomechanical Study of Variations in Suture Application in Human Cadavera Gregory N Nelson, Eleni Ntouvali, Ryan Potter, Matthew Silva, Martin I Boyer, Richard H Gelberman, Stavros Thomopoulos Posters Poster No. 2238 Biomechanical evaluation of three different fixation methods of the Chevron osteotomy of the olecranon: An analysis with RSA Marc Wagener, Nico Verdonschot, Denise Eygendaal, Marco Driesprong, Petra Heesterbeek Poster No. 2251 Evaluation of Flexor Tendon, Volar plate and A1 Pulley using Ultrasonography in Trigger Finger Junko Sato, Yoshinori Ishii, Hideo Noguchi, Mitsuhiro Takeda Poster No. 2252 Motion analysis of fingertip trajectory under different levels of lumbrical muscle activation Yusaku Kamata, Toshiyasu Nakamura, Shinjiro Sueda, Mitsunori Tada, Dinesh K Pai, Takeo Nagura, Yoshiaki Toyama Poster No. 2253 Squeaking in Pyrolytic Carbon Arthroplasty of the Proximal Interphalangeal Joint Caleb Davis, Lawrence J Berglund, Andrew R Thoreson, Steven L Moran, Kai-Nan An, Peter C Amadio Poster No. 2254 Bone remodeling after PIP joint arthroplasty using pyrocarbon, a material isoelastic to bone Magnus Tagil, Mats Geijer, Philippe Kopylov PS2 Muscle Poster No. 2255 Transcutaneous Carbon Dioxide Application for Muscle Atrophy after Femoral Shaft Fracture in Rat Keisuke Oe, Takahiro Niikura, Yoshitada Sakai, Sang Yang Lee, Akihiro Koh, Takaaki Koga, Yoshihiro Dogaki, Takeshi Ueha, Ryosuke Kuroda, Masahiko Miwa, Masahiro Kurosaka Poster No. 2256 In vivo imaging of magnetic targeted bone marrow mesenchymal stem cells in skeletal muscle injury Akihiro Nakabayashi, Naosuke Kamei, Akira Kodama, Shingo Ohkawa, Toru Sunagawa, Osami Suzuki, Mitsuo Ochi Poster No. 2257 Does Muscle Fibrosis Contribute to Contracture Formation Following Neonatal Brachial Plexus Injury? Sia Nikolaou, Liangjun Hu, Holly Weekley, Christopher Wylie, Roger Cornwall Poster No. 2258 Alterations in the Mechanical Properties of the Multifidus Muscle in Response to Pain Mark A Chapman, Margie Mathewson, Tomonori Yamaguchi, Mitsuru Naiki, Koichi Masuda, Richard L Lieber 165 Posters Poster No. 2259 Acupuncture Ameliorated Skeletal Muscle Atrophy Induced by Hindlimb Suspension in Mice Akiko Onda, Qibin Jiao, Yasuharu Nagano, Takayuki Akimoto, Toshikazu Miyamoto, Susumu Minamisawa, Toru Fukubayashi Poster No. 2260 Role of MMP-2 in Skeletal Muscle Atrophy after Hindlimb Suspension Sunil K Joshi, Qia Zhang, Xuhui Liu, Marissa Maimone, Hubert Kim Poster No. 2261 A comparison of Atrophic Muscle Biomechanics Following Tendon Rupture and Hindlimb Suspension Qia Zhang, Xuhui Liu, Givenchy Manzano, Hubert Kim Poster No. 2262 Functional Analysis of Limb Recovery with Autograft Treatment following Volumetric Muscle Loss in the Quadriceps Femoris Mon-Tzu A Li, Nick J Willett, Taran S Lundgren, Brent A Uhrig, Robert E Guldberg, Gordon L Warren Poster No. 2271 Enhanced Myoblast Attachment in Co-culture with Fibroblasts on Chitosan-coated Polypropylene Mesh for Skeletal Muscle Tissue Engineering Natasha Udpa, Bryan N Brown, Helen Valentine, Bhupinder Singh, Lawrence Bonassar, Yingxin Gao Poster No. 2272 Magnetic targeting of human peripheral blood CD133+ cells promotes skeletal muscle regeneration Shingo Ohkawa, Naosuke Kamei, Goki Kamei, Ming Shi, Nobuo Adachi, Masataka Deie, Mitsuo Ochi Poster No. 2263 Does a previous meniscus injury alter activity of the knee musculature during balance tasks? Lynsey Duffell, Alison McGregor Poster No. 2273 Transplantation of adipose tissue-derived regenerative cells for skeletal muscle regeneration Ryo Mori, Naosuke Kamei, Shingo Ohkawa, Akihiro Nakabayashi, Kazunori Yokota, Yuji Yasunaga, Mitsuo Ochi Poster No. 2264 Elevation of Systemic Myostatin Levels in Patients Recovering From Anterior Cruciate Ligament Reconstruction Christopher L Mendias, Evan B Lynch, Max E Davis, Julie A Harning, Christopher P Walsh, Elizabeth R Sibilsky Enselman, Asheesh Bedi Poster No. 2274 A Rat Tail Model for Fatty Degeneration of Back Muscle in Kyphotic Spine Ryao Fou, Koshi N Kishimoto, Yoshiaki Itoigawa, Hiroshi Okuno, Hideo Saito, Eiji Itoi Poster No. 2265 A Method for Creating a Clinically Relevant Standardized Single Stretch Injury in Mice Adam W Pala, Ray Vanderby, Ron McCabe, Stacey Brickson Poster No. 2275 Analysis of Molecular Mechanisms And Changes in Muscle Architecture Involved in Age-Related Muscle Mass Decrease: A Study on Patients of Different Age Giovanni Trisolino, Maria Conte, Catia Lanzarini, Laura Bucci, Giovanni Bracci, Ermanno Martucci, Olivier Seynnes, Miriam Capri, Stefano Salvioli, Marco Narici, Gillian Butler-Browne, Claudio Franceschi Poster No. 2266 Improvement in the contractility and muscle stem cell density of the supraspinatus following surgical repair Max E Davis, Patrick L Stafford, Joshua R Bradley, Evan B Lynch, Jonathan P Gumucio, Asheesh Bedi, Christopher L Mendias Poster No. 2267 Muscle-Derived Cells Isolated from a Murine Model of Accelerated Aging have a Limited Differentiation and Impaired Tissue Regeneration Potential Mitra Lavasani, Andria Robinson, Aiping Lu, Minjung Song, Joseph M Feduska, Bahar Ahani, Jeremy Tilstra, Chelsea H Feldman, Paul D Robbins, Laura Niedernhofer, Johnny Huard Poster No. 2268 Relationship Between Muscle Cells with Elevated Aldehyde Dehydrogenase Activity and Muscle Derived Stem Cells Seth D Thompson, Johnny Huard, Joe Vella Poster No. 2269 Muscle-derived Cells with High Levels of Aldehyde Dehydrogenase Activity Increase Force and Reduce Fibrosis in Compartment Syndrome Injured Skeletal Muscle Nick Oyster, Burhan Gharaibeh, Aoron Boyer, Adam Wright, Michelle Witt, Xiaodong Mu, Johnny Huard 166 Poster No. 2270 The Use of Thrombin-activated Platelet-Rich Plasma as a Medium Supplement for Human Muscle Derived Progenitor Cells Expansion and Pre-condition Hongshuai Li, Arvydas Usas, Chienwen Chen, Minakshi Poddar, Xueqin Gao, Johnny Huard Poster No. 2276 Do Mouse Arm Muscles Serve as a Good Model of Human Arm Muscles? Margie Mathewson, Mark Chapman, Richard Lieber Poster No. 2277 laceration-induced expression of rspondin-1 and galectin-1 in skeletal muscle regeneration Han Hwanchour, Barry Pereira, Suresh Nathan Poster No. 2278 Inhibition in Skeletal Myogenic Differentiation and Myotube Formation by a Cigarette Smoke-Associated Hydrocarbon Rong-Sen Yang, Chen-Yuan Chiu, Yuan-Peng Yen, Shing-Hwa Liu PS2 Ligament and Tendon Mechanics Poster No. 2279 Anterior Cruciate Ligament: An Anatomic Exploration in Different Species Gof Tantisricharoenkul, Monica A Linde-Rosen, Paulo Araujo, Jingbin Zhou, Freddie H Fu Poster No. 2291 Biomechanical Comparison of ACL Reconstruction Femoral Anchors Using a Novel Test Method Mark Ehrensberger, Donald W Hohman, Leslie Bisson Poster No. 2281 The femoral insertion of the anterior cruciate ligament: discrepancy between macroscopic and microscopic anatomical observations Norihiro Sasaki, Yasuyuki Ishibashi, Eiichi Tsuda, Yuji Yamamoto, Shugo Maeda, Satoshi Toh Poster No. 2292 Tibiofemoral Relationship before and after Anatomic Anterior Cruciate Ligament Reconstruction Tomohiko Matsuo, Tatsuo Mae, Konsei Shino, Keisuke Kita, Kazuomi Sugamoto, Hideki Yoshikawa, Ken Nakata Poster No. 2282 Accurate Length Measurements of ACL and PCL of a Healthy Patient during Weight-Bearing Deep Knee Bend Joseph W Mitchell, Mohamed Mahfouz, Nicholas V Battaglia Poster No. 2293 The Effects of Anatomic and Non-Anatomic Anterior Cruciate Ligament Augmentation on Knee Rotational Stability: A Biomechanical Study in Porcine Knees Can Yapici, Kenan Keklikci, Donghwi Kim, Dongliang Shi, Monica A LindeRosen, Patrick Smolinski, Freddie H Fu Poster No. 2283 The Anteromedial and Posterolateral Bundles of the Ovine ACL Demonstrate Physical Interaction and Distinct Patterns of Load Sharing Under Increasing Anterior Tibial Loads Mohammad Atarod Pilambaraei, Etienne O’Brien, Cyril B Frank, Nigel G Shrive Poster No. 2284 The Effect of Intraoperative Patient Position in Anterior Cruciate Ligament Reconstruction Yasuhiro Nishimori, Masahiro Nozaki, Masaaki Kobayashi, Hideyuki Goto, Masahito Yoshida, Kaneaki Tawada, Takanobu Otsuka Poster No. 2285 The Effect of Knee Flexion Angle on Appearance of the “Clock Face Position” in ACL Reconstruction Jonathan T Bravman, Ali Hosseini, Guoan Li, Thomas J Gill Poster No. 2286 Location of Tibial Tunnel Exit Hole in Transtibial ACL Reconstruction Genevra L Stone, Ali Hosseini, Thomas J Gill, Guoan Li Poster No. 2287 The relationship between ACL femoral insertion site and bony landmark of lateral femoral condyle Masahiro Nozaki, Masaaki Kobayashi, Hideyuki Goto, Yasuhiro Nishimori, Atsunori Murase, Masahito Yoshida, Kaneaki Tawada, Yuko WaguriNagaya, Hirotaka Iguchi, Nobuyuki Watanabe, Takanobu Otsuka Poster No. 2288 Isometric Placement of a Synthetic ACL Graft Dane Dabirrahmani, Michael C Hogg, Daniel Biggs, Peter Walker, Jacques Philippe Laboureau, Ronald M Gillies Poster No. 2289 Finite Element Analysis of Various Graft Positions for ACL Reconstruction Scott Kramer, Patrick Smolinski, Freddie H Fu Poster No. 2290 Predicting the Pullout Strength of Interference Devices for Anterior Cruciate Ligament Reconstruction: A Comparative Study Kathryn E Smith, Mateo Garcia, Kadija McAnuff, Robert Lamell, Christopher M Yakacki, Jack N Griffis, Ken Gall Posters Poster No. 2280 The Femoral insertion area of anterior cruciate ligament Yoshimasa Fujimaki, Shugo Maeda, Motoko Miyawaki, Paulo Araujo, James Irrgang, Scott Tashman, Freddie H Fu Poster No. 2294 Differences in Active Torsional Stiffness of ACL Reconstructed versus Healthy Contralateral Knees Michael Zabala, Sean Scanlan, Joseph Donahue, Thomas P Andriacchi Poster No. 2295 Biomechanical Comparisons of Knee Stability after Anatomic Double-bundle ACL Reconstruction between 2 Clinically Available Surgical Techniques: Trans-tibial versus Trans-portal Procedures Eiji Kondo, Azhar Merican, Kazunori Yasuda, Andrew A Amis Poster No. 2296 Ultrastructure of the two anterior cruciate ligament bundles Daisuke Suzuki, Hidenori Otubo, Miki Kudo, Mineko Fujimiya, Konsei Shino Poster No. 2297 The function of the two bundles of the posterior cruciate ligament an in-vivo study using dynamic stereo X-ray system (DSX) Daniel Hensler, Volker Musahl, Kenneth D Illingworth, Eric D Thorhauer, Scott Tashman Poster No. 2298 Arthroscopically Pertinent Anatomy of the Anterolateral and Posteromedial Bundles of the Posterior Cruciate Ligament Daniel J Westcott, Colin J Anderson, Connor G Ziegler, Coen A Wijdicks, Lars Engebretsen, Robert F LaPrade Poster No. 2299 Radiographic Landmarks for Tunnel Positioning in PCL Reconstructions Adam M Johannsen, Daniel J Westcott, Robert F LaPrade, Coen A Wijdicks, Lars Engebretsen Poster No. 2300 The Fixation Strength of Femoral PCL Reconstructions: A cadaveric study Stefan Budde, Max Ettinger, Carl Haasper, Emmanouil Liodakis, Urs-Vito Albrecht, Christian Krettek, Christof Hurschler, Michael Jagodzinski Poster No. 2301 Characterization of the Orientation and Isometry of Humphrey’s Ligament Michael B Cross, Bradley Raphael, Travis Maak, Christopher Plaskos, Claus Egidy, Andrew Pearle 167 Posters Poster No. 2302 Mechanical and biochemical effects of inhibiting collagen crosslinking in developing embryonic tendon Joseph E Marturano, Catherine K Kuo Poster No. 2303 Low Magnitude, High Frequency Vibration to Accelerate Ligament Healing Matthew L Davis, Benjamin Keller, Laurence E Dahners, Paul S Weinhold Poster No. 2304 Intratendinous TGF-β1 Injection with Treadmill Running Causes A Major Loss In Tensile Properties of the Achilles Tendon of Adamts5 Knockout but not Wild Type Mice Rebecca Bell, Anne Bartels, Hari Vigneswaran, Jun Li, Jorge Galante, John Sandy, Anna Plaas, Vincent M Wang Poster No. 2305 Biomechanical Properties of Achilles Tendons in db/db Mice Treated with Spironolactone or Rosiglitazone Greg P Boivin, Andrew Schultze, Egleide Elenes, Harshita Chodavarapu, Shawn Hunter, Khalid Elased PS2 Ligament and Tendon Biology Poster No. 2306 The Role of Smad3 in Tendon Development and Maintenance Ellora B Berthet, Carol Chen, Tamara Alliston, Mohana Amirtharajah Poster No. 2307 The Effects of TGF-β1 on the Expression of Extracellular Matrix Proteins and Their Regulators in Flexor Tendon Fibroblasts Cultured in Pinned 3-D Collagen Matrices Youssef Farhat, Tony Chen, Alaa Al-Maliki, Subhash Juneja, Regis J O’Keefe, Edward M Schwarz, Hani A Awad Poster No. 2308 Enhancement of transforming growth factor beta 1 and type I collagen expressions in tenocytes through low-magnitude vertical vibration stimulation Chau-Zen Wang, Gwo-Jaw Wang, Mei Ling Ho, Chia-Hsin Chen Poster No. 2309 Rac1 and RhoA activity cooperate to induce a tenocyte-like phenotype Rowena McBeath, Linda Sandell Poster No. 2310 A system dynamic approach to understand tendon response to mechanical stimuli Mathieu Viens, Denis Rancourt, Eve Langelier Poster No. 2311 Alterations in Cell Traction Forces Induce Changes in Metabolic State in Isolated Tenocytes Eijiro Maeda, Megumi Sugimoto, Toshiro Ohashi Poster No. 2312 Cyclic tensile strain stimulates CCN2/CTGF expression in human anterior cruciate ligament-derived cells Yoshiaki Miyake, Takayuki Furumatsu, Satoshi Kubota, Kazumi Kawata, Toshifumi Ozaki, Masaharu Takigawa 168 Poster No. 2313 Effect of cyclic tensile strain on anterior cruciate ligament cells cultured in three-dimensional scaffold Naoki Takata, Takayuki Furumatsu, Nobuhiro Abe, Yusuke Yokoyama, Keiji Naruse, Toshifumi Ozaki Poster No. 2314 The Proteomic Difference between Male and Female Anterior Cruciate Ligament and Patellar Tendon Dianne Little, J. Will Thompson, Laura G Dubois, Martin A Moseley, David S Ruch, Farshid Guilak Poster No. 2315 The Effects of Lidocaine, Ropivicaine, and Dexamethasone on Cultured Bovine Tenocytes Givenchy Manzano, Samantha Piper, Dominique Laron, Tanaya Pattnaik, Alfred Kuo, Hubert Kim, Brian Feeley Poster No. 2316 Diabetes Mellitus Compromises Expression of Tendon Repair Molecules Paul W Ackermann, Aisha Ahmed, Nicos Schizas, Lian Li, Mahmood Ahmed, Robert C Bray, Paul Salo, Carol Hewitt, David Hart Poster No. 2317 Influence of Age on the Cell Biological Characteristics and the Stimulation Potential of Human Tenocyte-like Cells Franka Klatte, Stephan Pauly, Markus Scheibel, Stefan Greiner, Christian Gerhardt, Gerhard Schmidmaier, Britt Wildemann Poster No. 2318 Enhancement of Cell Proliferation by Irradiation Using Xenon Flash Light in Tenocytes Derived Rat Achilles Tendon Haruhiko Satonaka, Masaya Tsujii, Takahiro Iino, Takeshi Uemura, Kazuichiro Hori, Katsuyuki Kusuzaki, Akihiro Sudo Poster No. 2319 Histopathologic Changes in the Posterior Cruciate Ligament During Aging and Osteoarthritis Yadin D Levy, Akihiko Hasegawa, Shantanu Patil, Martin Lotz, Darryl D D’Lima Poster No. 2320 Characterization of Age-Dependent Changes at the Anterior Cruciate Ligament (ACL) to Bone Enthesis Sagaw Prateepchinda, Philip J Chuang, Joshua Heisler, Helen Lu, Stephen B Doty Poster No. 2321 Quantitative Morphological Classification of Spinal Ligament Degeneration Aaron Cannon, Ashutosh Parajuli, Anton E Bowden Poster No. 2322 Analysis of Vascularity of the Interosseous Ligament Complex Prasad J Sawardeker, Robert A Duerr, Check C Kam, Elizabeth A Ouellette Poster No. 2323 Development and characterization of two experimental tendinosis models for bioreactor studies Yoan Lemieux-LaNeuville, Paule Cousineau-Pelletier, Denis Gagnon, Eve Langelier Poster No. 2325 Increased expression of IL6 family members in tendon pathology Kirsten Legerlotz, Eleanor Jones, Hazel R Screen, Graham P Riley Poster No. 2326 Platelet-Rich Plasma Prevents from Impairing Tenocytes by Triamcinolone Acetonide Tomoyuki Muto, Yutaka Mifune, Hanako Nishimoto, Ryosuke Sakata, Issei Nagura, Takeshi Kokubu, Masahiro Kurosaka Poster No. 2335 A comparative study of calcium phosphate bone cement enriched with strontium on enhancing tendon-bone osteointegration in a rabbit anterior cruciate ligament reconstruction model Guan-Ming Kuang, Wai-Pan Yau, William W Lu, Kwong-Yuen Chiu Posters Poster No. 2324 Reduction in Scleraxis and FSP-1 Expression in the Epitenon of Patients with Tendinosis Christopher L Mendias, Max E Davis, Patrick L Stafford, Evan B Lynch, Jonathan P Gumucio, Asheesh Bedi Poster No. 2336 Quantitative Proteomic Analysis of Human Tendon and Ligament Nori Sato, Takako Taniguchi, Yuichiro Goda, Hirofumi Kosaka, Kosaku Higashino, Toshinori Sakai, Koichi Sairyo, Shinsuke Katoh, Hisaaki Taniguchi, Natsuo Yasui Poster No. 2327 Macrophage populations and the Lipoxin A4 receptor in tendinopathy Stephanie G Dakin, Dirk Werling, Andrew Hibbert, Dilkush R Abayasekara, Natalie J Young, Roger K Smith, Jayesh Dudhia Poster No. 2328 WITHDRAWN Poster No. 2329 Relationship between Apoptotic Response in the Tendon and Initial Mechanical Parameters after Fatigue Loading Nelly Andarawis-Puri, Damien Laudier, Jedd B Sereysky, MItch B Schaffler, Evan L Flatow Poster No. 2330 Platelet-Rich Plasma as a Treatment For Patellar Tendinopathy: A Double-Blind Randomized Controlled Trial Jason Dragoo, Amy Wasterlain, Hillary J Braun Poster No. 2331 Platelet-Rich Plasma Stimulates Proliferation of Human Tenocytes by Activating both ERK and Akt Pathways and Potently Up-Regulates Growth Factor Production by Tenocytes Sarah Franklin, Mark Thompson, Andrew Carr, Keith Willett, Philippa Hulley Poster No. 2332 Short Term Tissue Response to Current Treatments for Rotator Cuff Tendinopathy Richard J Murphy, Karolina Kliskey, Kim Wheway, David J Beard, Andrew J Carr Poster No. 2333 Ectopic Ossification in the Regenerated Tissue at the Tendon Defect Site Takaaki Ohmachi, Tadahiro Sakai, Hideki Hiraiwa, Takashi Hamada, Motoshige Nakashima, Yohei Ohno, Shinya Ishizuka, Tetsuya Matsukawa, Akira Takamatsu, Tomoyuki Oda, Satoshi Yamashita, Naoki Ishiguro Poster No. 2334 Cyclic Tensile Stress Upregulates the Expression of Β-Catenin Signaling in Cultured Cells Harvested from Human Ossified Ligamentum Flavum Takafumi Yayama, Kenzo Uchida, Daisuke Sugita, Hideaki Nakajima, Guerrero R Alexander, Ai Yoshida, Naoto Takeura, Hisatoshi Baba 169 170 2012 Exhibitors 171 2012 Exhibitors AccelLAB 1635 Lionel-Bertrand Blvd Boisbriand, Quebec J7H 1N8, Canada Phone: (450) 435-9482 Fax: (450) 435-4795 WEB: www.accellab.com AccelLAB is a preclinical CRO that conducts product safety/efficacy studies for medical devices under GLP conditions. On-site surgeries are performed in a hybrid OR equipped with CT. Implantation is followed by histology, histomorphometry, histopathology, blood cell count and biochemistry. Imaging modalities include radiography, MRI, Micro CT and whole-body CT. AccelLAB is fully accredited by AAALAC International. Active Life Scientific, Inc 460 Ward Drive Ste. E1 Santa Barbara, CA 93111 Phone: (805) 770-2600 Fax: (805) 770-2606 WEB: www.activelifescientific.com Active Life Scientific, Inc. develops and markets BioDentTM, the world’s first Reference Point Indenter (RPI). RPI enables scientists to easily include tissue level strength, quality, and mechanical property data in their research. The in situ and in vivo testing modes enable first of its kind translational research. AGINKO Research AG Route de l’ancienne Papeterie 1723 Marly Switzerland Phone: (41) 31 331 7679 Fax: (41) 41 560-8053 WEB: www.aginko.com AGINKO Research: From concept to the patient. We are a full service contract research organization (CRO), experienced in performing preclinical, clinical and proof of concept studies in bone and joint diseases. We offer states of the art training suites for manufacturers. Aginko Research is a proven and committed partner to drug developers and medical device manufacturers looking to bring innovative new products to the market worlwide. 172 ALL-HEX 5201 Great America Pkwy Ste. 320 Santa Clara, CA 95054 Phone: (408) 562-6120 Fax: (408) 878-6001 WEB: www.all-hex.com ArthroCare Sports Medicine 7000 W. William Cannon, Bldg One Austin, TX 78735 Phone: (512) 391-3900 Fax: (512) 391-3901 WEB: www.arthrocare.com SPC TeleEngineering Corporation provides ALL-HEX, an automatic hex meshing tool for dynamic and nonlinear simulation. ALL-HEX generates its best meshes for smooth and bulky shapes like bones. ALL-HEX also automatically generates meshes for multiple materials, e.g. a combination of soft tissue and bones. The plug-in is available only for Altair HyperMesh. ArthroCare Sports Medicine develops innovative products for arthroscopy. ArthroCare’s industry leading Coblation platform now features the Ambient Arthrowand Collection, the first and only line of RF wands to provide real-time visual and audio feedback of the joint space fluid temperature. ArthroCare also offers a full range of innovative fixation solutions, including knotless and knotted repairs for rotator cuff and labrum. AMTI 176 Waltham St Watertown, MA 02672 Phone: (617) 926-6700 Fax: (617) 926-5045 WEB: www.amti.biz Articular Engineering 1818 Skokie Blvd Northbrook, IL 60062 Phone: (847) 498-9634 Fax: (847) 498-9638 WEB: www.articular.com AMTI is the world leader in biotribology and true-to-life joint simulation. We have designed our simulators to go far beyond gait alone and given them the range of motion associated with activities of daily living (ADLs), like getting out of a bathtub, walking up or down stairs, squatting to pick something up, and even swinging a golf club. Our ADL simulators offer the capability of both force and displacement control and incorporate a host of advanced features. Our iterative learning control achieves new levels of tracking performance and ease of use, and our Virtual Soft Tissue control uses software to apply the influence of the knee’s constraining tissues to the simulation. We offer multiple-station hip, knee, and spine simulators, as well as a single-station joint simulator and a multidirectional pin-on-disc machine with six stations. AE specializes in production of high-quality, standardized orthopaedic cell and tissue cultures. We provide a consistent platform on which early to mid-stage researchers can rely. Our products include human and animal source cultures, tissues for research (live, preserved for molecular biology and histology, bodily fluids), certified media and cryopreserved cells. ATI Industrial Automation 1031 Goodworth Drive Apex, NC 27539 Phone: (919) 772-0115 Fax: (919) 772-8259 WEB: www.ati-ia.com ATI Industrial Automation’s Multi-Axis Force/Torque Sensors measure all components of force and torque (Fx, Fy, Fz, Tx, Ty, and Tz) and are used in a wide variety of applications including; robotic surgery, haptics, rehabilitation, and neurology. Key features include: High overload protection, high-speed output, span temperature compensation, and high signal-to-noise ratio. Biomomentum develops, manufactures, and sells biomechanical products and provides specialized testing services in biomechanics. The Mach-1™ is a laboratory instrument designed for the evaluation of the mechanical properties of soft biological samples and the ArthroBST™ is a medical device developed for precise, non-destructive evaluation of articular cartilage during arthroscopic surgery. BioSpherix, Ltd P.O. Box 89 Lacona, NY 13083 Phone: (315) 387-3414 Fax: (315) 387-3415 WEB: www.biospherix.com Research: Wide range of hypoxia systems for In Vitro/In Vivo. Advanced features include multiple simultaneous levels, timed and intermittent exposures, uninterruptible hypoxia, dissolved oxygen cell culture, etc. Cell Therapy: Xvivo System, first and only barrier isolator optimized for cells. Economical and practical alternative to cleanrooms for cGMP cell production. BioTime, Inc. 1301 Harbor Bay Pkwy Alameda, CA 94502 Phone: (510) 521-3390 Fax: (510) 521-3389 WEB: www.biotimeinc.com BioTime, a biotechnology company headquartered in the San Francisco Bay Area, is committed to biomedical research and product development in regenerative medicine. We also market and sell human embryonic stem and progenitor cell products and research reagents. Our ACTCellerate collection of human embryonic progenitor (hEP) cell lines comprises a total of over 140 clonally-purified cell lines that display many features consistent with an embryonic state. Visit booth 220 to learn more! Bone & Joint Research (from the publishers of JBJS Br) 22 Buckingham Street London, WC2N 6ET United Kingdom Phone: (44) 207-782-0010 Fax: (44) 207-782-0995 WEB: www.bjr.boneandjoint.org.uk Cleveland Clinic Lerner Research Institute 9500 Euclid Ave Mail Stop ND20 Cleveland, OH 44195 Phone: (216) 444-2701 Fax: (216) 444-9198 WEB: www.lerner.cff.org/services We are delighted to announce the launch of Bone & Joint Research, a major new open access journal from the publishers of JBJS (Br) focusing on research in the musculoskeletal sciences. Cleveland Clinic Lerner Research Institute: Computational Biomodeling Core offers advanced computational modeling for simulation-based medicine; utilizing stateof-the-art approaches among a variety of disciplines: engineering, physiology, and computer science. Visit booth #229 to pick up your free 2G flash drive with instructions for authors and meet Editor-in-Chief Professor Andy Carr. BOSE Corporation-ElectroForce Systems Group 10250 Valley View Road Suite 113 Eden Prairie, MN 55344 Phone: (952) 278-3070 Fax: (952) 278-3071 WEB: www.bose-electroforce.com Bose Corporation’s ElectroForce Systems Group introduces the ElectroForce® 3200 and 3330 Series II test instruments which incorporate a new high accuracy displacement sensor for the characterization of orthopaedic tissues and biomaterials. Our BioDynamic® test instruments advance tissue engineering by providing a novel approach to specimen stimulation and characterization. Visit our booth for a demonstration! Cambridge Polymer Group, Inc. 56 Roland Str Boston, MA 02129 Phone: (617) 629-4400 Fax: (617) 629-9100 WEB: www.campoly.com 2012 Exhibitors Biomomentum Inc. 970, rue Michelin, Ste. 200 Laval, H7V 5C1, Canada Phone: (450) 667-2299 Fax: (450) 686-8952 WEB: www.biomomentum.com BioRobotics and Mechanical Testing Core provides services for biomechanical modalities including robotic testing of cadaveric knees, hips, shoulders, foot/ ankle, and spines. C-Motion 20030 Century Blvd Ste. 104A Germantown, MD 20874 Phone: (301) 540-5611 Fax: (301) 540-5613 WEB: www.c-motion.com C-Motion has a passion for making the world’s leading research tools for understanding the mathematically complex nature of movements in 3D. Our software Visual3D, is hardware independent, marker set independent, functionally extensible, and has the most capable modelling capabilities available. It provides clinically validated, consistent results from motion capture data. Its analytical power and object architecture make it a compelling product for clinical assessments, visualizing 3D data, rehabilitation assessments, animal research, sports related motion, virtual reality activities, and many other applications. Email: info@c-motion.com Cambridge Polymer Group, Inc. is a contract research organization specializing in materials. We partner with our clients to solve problems utilizing our multidisciplinary research team and full service laboratory. We provide materials, testing and engineering solutions for clients worldwide. 173 2012 Exhibitors CSM Instruments 197 1st Ave Ste. 120 Needham, MA 02494 Phone: (781) 444-2250 Fax: (781) 444-2251 WEB: www.csm-instruments.com CSM Instruments offers a wide range of instruments and testing services for surface mechanical properties characterization, including: nano and micro indentation (for hardness and modulus); nano and micro scratch (thin film adhesion, fracture and deformation); tribometers (also high temperature and linear reciprocating options); and Calotest. 3D-imaging options are available with the ConScan or AFM objective. DaVINCI Biomedical Research 113 Morning Mist Drive Garner, NC 27529 Phone: (919) 661-8443 Fax: (919) 550-6318 WEB: www.davincibiomed.com DaVINCI Biomedical Research is a CRO performing preclinical animal studies, GLP & Non-GLP. We have extensive experience in long & small bone, maxillofacial, and cranial applications as well as scaffold, joint, spinal and more. We offer high level surgical skills, mechanical engineering & testing via Instron Unit, CT imaging and more. We work with a large array of animal models (rats,swine,canine,sheep,goats, up to non-human primates). Our main facility, AAALAC accredited, is located just outside of Boston, MA. Contact Tony Nazal 919661-8443 or tnazal@davincibiomed.com GCTM Preclinical Division Clavadelestrasse 8 Davos, 7270, Switzerland Phone: (41) 81-414-2321 Fax: (41) 81-414-2288 WEB: www.gctm.com GCTM PreClinical Division is linked to the AO Research Institute Davos, Switzerland and offers preclinical services in collaborative research with both industry and universities. We provide a wide variety of animal models (mouse, rat, rabbit, sheep, minipig) for osteoarticular research. Further services include biomechanical testing, histological analysis, medical imaging, tissue engineering solutions and models for musculoskeletal infections. Innovative Sports Training is proud to provide The MotionMonitor, a totally integrated 3D motion analysis system for use in biomechanical, orthopaedic, and clinical applications involving the analysis of complex movements. Data from magnetic trackers, active markers, passive markers, EMG, forceplates, video, and other analog devices are collected through one platform, synchronized, and presented in real-time. Glycosan 1301 Harbor Bay Pkwy Alameda, CA 94502 Phone: (510) 521-3390 Fax: (510) 521-3389 WEB: www.glycosan.com Instron® 825 University Avenue Norwood, MA 02062 Phone: (800) 877-6674 Fax: (781) 575-5725 WEB: www.instron.com Glycosan is headquartered in the San Francisco Bay Area. Our biocompatible hydrogel matrices connect cell culture with cell therapy. Hystem® hydrogels are made from naturally occurring hyaluronan. They are also customizable and injectable, providing a lifelike cellular microenvironment for orthopedic applications. Please visit us at booth #218 to learn more! The ElectroPuls™ E1000, Instron’s nonhydraulic testing system, performs both static and dynamic testing for numerous orthopaedic applications including spine, dental, joints, and native and bio-engineered tissues. Instron systems are used extensively in the orthopaedic industry, providing customers with comprehensive solutions for material and device characterization. Instron offers a range of systems to satisfy development, quality and service-life testing requirements. Histion 2615 W. Casino Rd, Ste. 6G Everett, WA 98204 Phone: (425) 347-0439 Fax: (425) 353-3604 WEB: www.histion.com Histion specializes in analysis of medical devices (including drug/device and biologic/ device combinations) with a proven track record of success providing data to support regulatory submissions. Services include consulting, design and execution of preclinical studies, soft and hard tissue histology, precision cutting/grinding, immunohistochemistry, histopathology, histomorphometry, micro-CT analysis and mechanical testing. 174 Innovative Sports Training 3711 N. Ravenswood Ave Suite 150 Chicago, IL 60613 Phone: (773)244-6470 Fax: (773)244-6473 WEB: www.innsport.com IOP Publishing 150 S. Independence Mall W Philadelphia, PA 19106 Phone: (215) 627-0880 Fax: (215) 627-0879 WEB: www.iopscience.org/bmm IOP Publishing is an international, not-forprofit, learned society publisher. We are a world leader in scientific publishing and the electronic dissemination of peer-reviewed scientific research. Stop by our table for a sample copy of one of our renowned journals, such as Biomedical Materials (www.iopscience.iop.org/bmm) and Biofabrication (www.iopscience.iop.org/bf). ISIS Services, LLC is an AAALAC-accredited Contract Research Organization located in San Carlos, California. With over 25 years of working with medical device companies moving towards orthopedic innovation, ISIS has been an integral part of successful device development and has conducted preclinical GLP and non-GLP studies in a wide variety of species (rodents, rabbits, sheep, dogs, goats, and pigs) in various stages of orthopedic research. Our surgical teams have extensive experience in biocompatibility, bone grafts, bone defects and synthetic bone substitutes, joint reconstructions, prosthetics, ACL and MCL reconstruction, TKR, THR, spine, etc. We also conduct human cadaver studies for physician and sales force training. Our state-of-the-art facility has multiple ORs with various imaging modalities, as well as audio-visual conferencing capabilities. Lifecore Biomedical LLC 3515 Lyman Blvd Chaska, MN 55318 Phone: (952) 368-6321 Fax: (952) 368-4278 WEB: www.lifecore.com Lifecore Biomedical, LLC, specializes in aseptic filling and manufacturing of hyaluronan by fermentation and recently introduced Corgel™ BioHydrogel kits to the research community. Hyaluronan is used and Corgel is being evaluated in applications that range from ophthalmology and tissue engineering to orthopedics, wound healing and aesthetics, along with several others. Lippincott Williams & Wilkins 11636 Andasol Ave Granada Hills, CA 91344 Phone: (818) 363-0477 WEB: www.lww.com Lippincott Williams and Wilkins/ WK Health publishes the best selling, 4-volume, “Orthopaedic Surgery”, by Dr. Sam W. Wiesel, as well as Dr. Steven Burkhart’s just-published book, “Cowboy’s Companion: A Trail Guide for the Arthroscopic Shoulder Surgeon”. Come by and see these, and other exciting new titles. Materialise USA 44650 Helm Court Plymouth, MI 48170 Phone: (734)5853400 Fax: (734)662-7891 WEB: www.materialise.com Materialise has extensive experience in medical image processing with the Mimics Innovation Suite, which provides engineers, researchers and surgeons with the most detailed and precise anatomical models available. Mimics is a powerful, user friendly image processing software that translates medical images to CAD models, STL files or FEA meshes within minutes. Micro Photonics Inc. / Kubtec 4972 Medical Center Circle Allentown, PA 18106 Phone: (866) 334-4674 Fax: (610) 366-7105 WEB: www.microphotonics.com Micro Photonics, and partners Kubtec and SkyScan, are leading the advance in MicroCT and digital X-ray imaging solutions for biomaterials and life science research with a focus on bone morphology, BMD, and regenerative medicine. The Kubtec and SkyScan product lines meet the highresolution and versatility required for any demanding research laboratory. Motion Analysis Corporation 3617 Westwind Blvd Santa Rosa, CA 95403 Phone: (707) 579-6500 Fax: (707) 578-8473 WEB: www.motionanalysis.com Motion Analysis Corporation is the world’s largest manufacturer of high performance motion capture systems that test, measure, analyze and display the movement of humans, animals and objects. We supply a wide range of camera models to suit any application and budget. Our motion capture software, Cortex, comprises tracking, editing, scripting and modeling functions in a single integrated package. For our biomechanics customers, the fully integrated KinTools RT software adds realtime kinetics and kinematics analysis capabilities. 2012 Exhibitors ISIS Services, LLC 1031 Bing Street San Carlos, CA 94070 Phone: (510) 704-0140 Fax: (510) 704-0258 WEB: www.isis-services.com MTS Systems Corporation 1400 Technology Drive. Eden Prairie, MN 55344 Phone: (952) 937-4000 Fax: (952) 937-4515 WEB: www.mts.com Biomedical device manufacturers look to MTS for intelligent domain expertise and an extensive portfolio of testing solutions to meet research objectives. MTS offers a versatile array of highly accurate and reliable systems for biomaterial, medical device, medical packaging and consumables, and orthopaedic device testing applications. National Institutes of Health (NIH) 9000 Rockville Pike Bethesda, MD 20892 Phone: (301) 496-4000 WEB: www.nih.gov The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases is to support research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases. 175 2012 Exhibitors NIAMS 11300 Rockville Pike, Ste. 901 Bethesda MD 20892 Phone: (877) 226-4267 Fax: (301) 594-6047 WEB: www.niams.nih.gov NIAMS disseminates information about the causes, treatment, and prevention of diseases of bone muscles, joints, and skin. Northern Digital Inc 103 Randall Drive Waterloo, ON N2V 1C5 Phone: (519) 884-5142 Fax: (519) 884-5184 WEB: www.ndigital.com For almost 30 years, Northern Digital Inc. (NDI) has been providing researchers with the tools they need for research-grade motion capture. Today the company is a world leader in advanced 3D measurement technology, with over 14,000 installations in more than 30 countries. novel electronics inc 964 Grand Ave St. Paul, MN 55105 Phone: (651) 221-0505 Fax: (651) 221-0404 WEB: www.novelusa.com novel is quality in pressure distribution measurement and manufactures pressure measurement systems that are accurate and reliable for all testing requirements. novel offers three different systems; the emed platform, the pedar in-shoe, and the pliance system, which measures intraarticular pressure at the patella and tibia, hand/gripping pressures, and much more. Please visit www.novelusa.com for more detailed information. 176 Osteometrics, Inc 1240 Clairmont Rd Ste. 100 Decatur, GA 30030 Phone: (404) 876-1004 Fax: (404) 876-6004 WEB: www.osteometrics.com Redefining Bone Histomorphometry worldwide since 1989. Now available with outstanding live digital camera support, on-screen pen measurement, thresholding, complete set of Cortical Bone measurements, greatly expanded set of non-specific measurements, and comprehensive GLP validation package. Pacific Research Labs 10221 SW 188th Street Vashon, WA 98070 Phone: (206) 463-5551 Fax: (206) 463-0060 WEB: www.sawbones.com PACIFIC RESEARCH - SAWBONES WORLDWIDE offers a complete range of biomechanical composite analogue bones and blocks for mechanical testing. Designed to simulate the physical properties of human bone; these materials offer a more reliable test bed for biomechanical studies than cadaveric specimens. PharmaLegacy Laboratories Building 7, 388 Jialilue Road Zhangjiang High-Tech Park Shanghai Phone: +86-021-6100-2280 Ext. 2686 Fax: +86-021-6100-2270 WEB: www.pharmalegacy.com PharmaLegacy is a preclinical specialty CRO that has strong track records in services to worldwide companies committing R & D in therapeutics for Bone Metabolism/Orthopaedics and Tissue Engineering, besides Immune Diseases/ Inflammation and Tumor. We provide quality, timely and cost saving execution for experiments under GLP operation and AAALAC certification. Pre-Clinical Research Services, Inc. 1512 Webster Court Ft. Collins, CO 80524 Phone: (970) 232-1122 Fax: (970) 232-1126 WEB: www.preclinicalresearch.com Pre-Clinical Research Services, Inc., located in Ft. Collins, Colorado, provides pre-clinical services including: osteoarthritis models, antigen-induced arthritis, experimental surgery (surgical/medical device development, biomaterial implants, biocompatibility, selective catheterization and angiography), medical imaging: MRI, ultrasound, echocardiography and intra-operative fluoroscopy, toxicology and pharmacokinetics. Species include swine, small ruminants, rodents, rabbits, dogs, cats. Preclinical Surgical Services Piedmont Triad Research Park Winston Salem, NC 27157 Phone: (336) 713-7399 Fax: (336) 713-1404 WEB: www.preclinicalsurgicalservices.com Preclinical Surgical Services is a fullservice CRO focusing on proof-ofprinciple, method development, and efficacy testing in the preclinical medical technology research arena. Pre-surgical bench analysis, ex-vivo modeling, dynamic imaging and surgical models in all specialties. From concept to clinical applications, PSS is your innovation partner. Qualisys North America 500 Lake Cook Rd Deerfield, IL 60015 Phone: (847) 945-1411 Fax: (847) 282-5001 WEB: www.qualisys.com Qualisys Motion Systems is a global 3D motion capture leader that provides integrated mocap tools for: active and/ or passive markers; utilizing optical and/ or video 2D and 3D technology; whether in water and/or out of water assessments; performing indoors and or outdoor for recording real-time orthopedics, neurology, physical and sports medicine, performance enhancement, virtual reality, engineering, animal, fMRI, movement analysis, research and or clinical medicine activities. Sinclair Research Center LLC P.O. Box 658 Columbia, MO 65205 Phone: (573) 387-4400 Fax: (573) 387-4404 WEB: www.spirebiomedica.com TestResources, Inc. 701 Canterbury Rd. S Shakopee MN 55379 Phone: (952) 944-6534 Fax: (952) 516-5391 WEB: www.testresources.com Scanco Medical (www.microCT.com) is the leading global provider of mCT systems. Scanco also provides contract based scanning services for academic and industrial groups. The range of scanners offer capabilities of obtaining 3-dimensional images under 1 micron resolution. All systems are bundled with image analyses, 3D visualization and archiving solutions. Sinclair Research Center offers pre-clinical surgical services supporting orthopedic device/therapeutic development: Animal models of joint/articular cartilage/tendon repair, spinal disc replacement, spinal fusion, critical/non-critical segmental defects, long bone osteotomy, bone grafts, osteopenia, trabecular plate perforation. ISO 10993 Biocompatibility testing. AAALAC accredited, GLP compliant, PHS Assurance Statement. Minipig production (Sinclair, Hanford, & Yucatan), DMPK, toxicology, efficacy. TestResources is a manufacturer of modular all-electric dynamic and static test systems for biomedical/orthopedic testing applications. New products include an all-electric axial/torsion testing system for orthopedic research, a micro-force test system for tissue research, and a variety of new products for biomaterials engineering. Simpleware Ltd Innovation Centre Rennes Drive Exeter, UK EX4 4RN Phone: (44) 845-508-7240 Fax: (44) 139-224-7949 WEB: www.simpleware.com Simpleware provides world-leading mesh generation software and services converting 3D scan data into high-quality computer models used for CAD, Finite Element, CFD, and Rapid Prototyping. Simpleware software can be used to reconstruct models of human anatomy from MRI/CT, integrate implant data, and generate accurate computational models for orthopaedic research. SIMULIA 166 Valley Street Providence, RI 02909 Phone: (401) 276-8423 WEB: www.simulia.com SIMULIA is the Dassault Systèmes brand that delivers an extensive portfolio of Realistic Simulation solutions including the Abaqus product suite. By building on established technology, respected quality, and superior customer service, SIMULIA makes realistic simulation an integral business practice that improves product performance, reduces physical prototypes, and drives innovation. www.simulia.com SkyScan US / Microphotonics 5941 Optical Court San Jose, CA 95138 Phone: (408) 960-7453 Fax: (408) 960-3822 WEB: www.skyscan-us.com SkyScan is a fast growing company and one of the world’s leading producers of micro-ct systems for a wide range of applications. Skyscan aims to bring to customers the newest technology, the best instrument quality and the highest level of support. Responding to the demand from the growing community of micro-CT users, we are continually active in research and development into new methods for non-destructive 3D microscopy Tekscan 307 W. First Str. S. Boston, MA 02127 Phone: (617) 464-4500 Fax: (617) 464-4266 WEB: www.tekscan.com Tekscan, Inc. manufactures a broad range of pressure assessment and research evaluation tools. Orthopedic implant facilities and research institutions use Tekscan’s K-Scan™ System to study implant design and joint articulation. Other applications include determining orthotic/ wheelchair cushion efficacy, identifying potential ulceration areas, screening diabetic/neuropathic patients, and observing gait abnormalities. 2012 Exhibitors Scanco Medical P.O. Box 646 Southeastern, PA 19399 Phone: (610) 688-1440 Fax: (610) 688-4976 WEB: www.scanco.ch Tissue Growth Technologies 5929 Baker Rd Ste. 430 Minnetonka, MN 55345 Phone: (952) 933-1179 Fax: (952) 933-1186 WEB: www.tissuegrowth.com Tissue Growth Technologies, a leading supplier of bioreactors for mechanicallystimulated 3D tissue growth, offers products ranging from modular components to fully integrated systems. Chambers impart computer controlled mechanical forces to developing tissues in a real-time monitored, incubator friendly, sterile environment. TGT products allow researchers to design experiments, not instruments. Wiley-Blackwell 111 River Street Hoboken, NJ 07030 Phone: (201) 748-8893 Fax: (201) 748-6617 WEB: www.wiley.com Wiley-Blackwell is the international scientific, technical, medical and scholarly publishing business of John Wiley & Sons, with strengths in every major academic and professional field and partnerships with many of the world’s leading societies. For more information, please visit www.wileyblackwell.com or http://onlinelibrary.wiley.com. 177 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS MOSCONE WEST CONVENTION CENTER San Francisco, California N 820 15 72" TABLE W/10 CHAIRS Posters ORS TRANSACTION 72" TABLE W/10 CHAIRS INTERNET CAFE Bar 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS Innovative Sports Training 333 Cleveland Clinic-Lerner Research Institute 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 331 Aginko 329 72" TABLE W/10 CHAIRS 327 72" TABLE W/10 CHAIRS Biomomentum 325 Sinclair 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS Research Center 323 Simplaware 321 AcelLAB OREF 233 332 231 330 DaVinci Biomedical Research ORS 317 72" TABLE W/10 CHAIRS 315 Novel AMTI 223 322 NDI LWW 221 320 219 IOP Publishing 217 ISIS 215 Preclinical Surgical Services 130 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 228 226 Simulia ORS 127 126 Wiley 224 125 MTS ATI 123 222 Micro Photonics/ Kubtec BioTime, Inc 220 121 ArthroCare Sports Glycosan Medicine 318 314 TestResources 225 324 Qualisys Scanco Pacific Research Lab 131 Lifecore Biomedical ORS 316 Active Life Scientific, Inc 227 326 230 Bone & Joint Research 229 328 Articular PharmaEngineering Legacy 72" TABLE W/10 CHAIRS Motion Analysis Osteometrics Materialise BioSpherix Tissue Pre-Clinical Growth Research Technologies Services 319 72" TABLE W/10 CHAIRS 232 SkyScan 119 218 Histion 216 BOSE 214 72" TABLE W/10 CHAIRS ALL-HEX 72" TABLE W/10 CHAIRS 124 Posters Cambridge Polymer Group CSM Instruments 15' AISLE 72" TABLE W/10 CHAIRS 20' AISLE 72" TABLE W/10 CHAIRS Posters 72" TABLE W/10 CHAIRS Food & Bev. 72" TABLE W/10 CHAIRS C-Motion 72" TABLE W/10 CHAIRS 122 NIAMS 72" TABLE W/10 CHAIRS 120 NIH 72" TABLE W/10 CHAIRS 20' Instron 117 Tekscan 115 116 72" TABLE W/10 CHAIRS GCTM Preclinical Division 114 72" TABLE W/10 CHAIRS * Floor plan subject to change without notice. Exhibitor Registration Lead Retrieval/ ExpoBadge Freeman Service Desk ENTRANCE 6' TABLE 6' TABLE 6' TABLE NOTES 179 NOTES 180 NOTES 181 NOTES 182 H/RIGS TRY H/RIGS TRY 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS REGISTRATION 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 18'-11" AISLE 72" TABLE W/10 CHAIRS Posters 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 15 N 820 CSM 328 318 319 316 232 222 220 215 ISIS 217 Publishing IOP 219 214 BOSE 216 Histion 218 ArthroCare Sports Glycosan Medicine 221 BioTime, Inc MTS AMTI 223 LWW 224 225 Lifecore Biomedical 226 TestResources Pacific Research Lab 227 Active Life Scientific, Inc 228 230 Bone & Joint Research 229 231 Osteometrics Materialise 233 126 115 Tekscan 117 Instron 119 SkyScan 121 Micro Photonics/ Kubtec 123 ATI 125 72" TABLE W/8 CHAIRS ENTRANCE 114 GCTM Preclinical Division 116 20' NIH 120 NIAMS 122 C-Motion 124 ALL-HEX ORS Simulia 127 Wiley 130 131 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS Preclinical Surgical Services 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS Motion Analysis * Floor plan subject to change without notice. 72" TABLE W/8 CHAIRS 314 INTERNET CAFE AcelLAB OREF ORS TRANSACTION 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 6' TABLE 6' TABLE CHECK IN 6' TABLE 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS Posters 72" TABLE W/8 CHAIRS Freeman Service Desk Lead Retrieval/ ExpoBadge Exhibitor Registration 315 Qualisys Scanco 317 Articular PharmaEngineering Legacy Tissue Pre-Clinical Growth Research Technologies Services 320 NDI 322 Novel 324 ORS 326 ORS DaVinci Biomedical Research 330 BioSpherix 332 Instruments 321 Simplaware 323 Research Center Sinclair 325 Biomomentum 327 Cambridge Polymer Group 329 Aginko 331 Cleveland Clinic-Lerner Research Institute Innovative Sports Training 333 72" TABLE W/10 CHAIRS Posters 72" TABLE W/10 CHAIRS Bar 72" TABLE W/10 CHAIRS 20' AISLE 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS 72" TABLE W/10 CHAIRS CAREER CENTER Food & Bev. LEVEL 3 72" TABLE W/10 CHAIRS 15' AISLE Food & Bev. 2014 Session Room 2024 Session Room 2001 Ready Room 2006 2005 2002 Session Room Session Room Session Room LEVEL 2 12'-1" AISLE MOSCONE WEST CONVENTION CENTER San Francisco, California Meeting At-A-Glance Friday, February 3, 2012 2:00 PM - 5:00 PM Room 2002 Registration Open / Set Up Posters Session 1 Room 2005 Room 2006 Room 2014-2018 Saturday, February 4, 2012 7:00 AM - 6:00 PM Registration Open 8:00 - 9:30 AM 9:45 - 10:45 AM 11:00 AM 12:00 PM PAS I: Deciding what Journals to Publish in? Advantages and Disadvantages of Different Journals W1: Biomaterial Based Approaches Towards Minimally Invasive Treatment of IVD Degeneration W2: Personalized Fracture Risk Assessment and Treatment in Osteoporosis from PopulationBased to Patient-Specific Medicine W3: Current Insights on the Regenerative Potential for the Periosteum: S1: Stem Cells and Progenitors S2: Tendon & Ligament: Biology & Development S3: Molecular Influences on Cartilage Biomechanics S4: Inflammation in OA & ImmuneMedicated Arthritis S5: Cell and Molecular Biomechanics: Osteocytes S6: Intervertebral Disc: Stem Cells & Cell Line S7: Tendon and Ligament: Regeneration S8: Cell and Molecular Biomechanics: Physical Effects S9: Experimental OA Models: Lubrication and Pain S10: Fracture Healing - Quality SP11: Spine SP12: ACL Reconstruction SP13: Non-Coding RNA and Postranscriptional Regulation in OA SP14: Tissue Reactions to Wear SP15: Osteoporosis NIRA 1: Cartilage and Spine NIRA 2: Soft Tissue NIRA 3: Cartilage Biology & OA NIRA 4: Fracture Repair NIRA 5: Bone 12:00 - 1:30 PM 1:30 - 3:00 PM 3:15 - 4:15 PM View Posters & Visit Exhibitors 4:15 - 6:00 PM Poster & Exhibit (Authors Available at Posters to Answer Questions) RIG An Update on Research Topics and Future Directions in Intervertebral Disc Research 6:30 - 7:30 AM RIG Growth Factors Sunday, February 5, 2012 7:00 AM - 6:00 PM Registration Open 8:00 - 9:30 AM 9:45 - 10:45 AM 11:00 AM 12:00 PM 8:00 AM - 4:30 PM Poster and Exhibit Hours PAS II: Optimizing Skills for a Successful Research Career W4: New Insights into the Effects of Spaceflight in Musculoskeletal Tissues W5: Bone Infection: An Unresolved Problem W6: CT and MRI Metal Artifact Reduction Update W7: Translational Animal Models in Orthopaedic Research S16: Intervertebral Disc S17: ACL Injury Mechanics S18: Cartilage and Meniscus Repair S19: Cell Signaling S20: Bone - Aging S21: Bone and Spine Biomechanics S22: Tendon Biomechanics S23: Bone Mechanics S24: Cartilage Degradation Biomarkers and Imaging S25: Fracture Healing Modulation 12:00 - 1:30 PM 1:30 - 3:00 PM Poster & Exhibit (Authors Available at Posters to Answer Questions) / Meet the Mentors Luncheon (pre-registration required) SP26: Current Trends in Joint Replacement SP27: Tendon & Ligament: Translational Research SP28: microRNA 3:00 PM - 4:30 PM View Posters & Visit Exhibits / Poster Walking Tours 7:00 AM - 6:00 PM Registration Open 8:00 - 9:30 AM PAS III: Entrepreneurship for Academics in Orthopaedics: How to Get an Idea Out of the University Monday, February 6, 2012 4:30 PM - 5:00 PM Remove Posters Session 1 / 5:00-5:30 Set Up Posters Session 2 7:00 - 8:00 AM Business Meeting 9:00 AM - 6:00 PM Poster and Exhibit Hours ORS Awards Presentation / Presidential Address CRF 10:00 - 11:20 am The Story of Atypical Proximal Femur Fractures S31: Hip and Femoroacetabular Impingement S32: Knee and Hip Finite Element Modality CRF 11:35 am - 12:55 pm MOM: Were the Studies Strong Enough Before Implementation? S35: Tissue Engineering I: Cartilage and Bone S36: Biomaterials Stem Cells and Growth Factors CRF 2:00 - 3:50 pm: BMPs: How do we Detect Adverse Events that we weren’t Even Thinking About? S37: Meniscus S38: Osteolysis and Implant Fixation S39: Tissue Engineering II: Tendon S40: Polymeric and NanoBiomaterials CRF 3:55 - 4:30 pm: Closing the Loop: Changing Surgeons’ Minds when Confronted with New Information S41: Foot and Ankle S42: Growth Factors and Bone Fixation 4:00 - 6:00 PM Tuesday, February 7, 2012 W10: Building a Successful Research Program: Decisions, Victories and Pitfalls S33: The Post-Traumatic Joint Experimental Models S34: Muscle and Nerve Poster & Exhibit (Authors Available at Posters to Answer Questions) RIG Graduate Student Women’s Group RIG Bone Tissue: Hierarchical Simulations of Bone for Clinical Application 7:00 AM - 11:45 AM Poster and Exhibit Hour 8:00 - 9:30 AM W9: Focus Areas for Future Research in Total Knee and Total Hip Replacements View Posters & Visit Exhibits / Meet the Industry Members Luncheon (pre-registration required) 3:00 - 4:00 PM 6:30 - 7:30 AM SP30: Muscle/Bone CRF 8:00 - 9:45 am A Framework for Taking Innovation into Clinical Practice 12:15 - 1:30 PM 1:30 - 2:30 PM SP29: Regenerative Approaches to OA W8: Heterotopic Ossification in Orthopaedic Trauma 9:45 - 11:00 AM 11:15 AM 12:15 PM Room 2024 9:00 AM - 6:00 PM Poster and Exhibit Hours W11: Design, Implementation, Statistical Analysis and Reporting of Clinical Trials in Orthopaedics: RIG The Orthopaedic Evidence and Outcomes Education Organization 7:00 AM - 5:00 PM Registration Open W12: Recent Changes at the US Food & Drug Administration with Respect to Orthopaedic Devices W13: Metal-Metal Bearings: Facts, Fictions and Futures W14: Clinical Assessment of Acute Joint Injury and Early Joint Degeneration Keynote Speaker and Incoming Presidential Address 9:45 - 10:45 AM 10:45 - 11:45 AM Poster & Exhibit Session (Authors Available at Posters to Answer Questions) 11:45 AM - 1:00 PM Remove Posters Session 2 S43: Knee, ACL, Patello-Femoral Joint ORS/AAOS I: Adverse Reactions to Byproducts of Joint Replacements S44: Tumors and Diseases S45: Orthopaedic Infection S46: Cartilage Mechanics S47: Shoulder ORS/AAOS II: Basic & Clinical Science Advances in Understanding FAI S48: Spine S49: New Polyethylene Implant Wear S50: Knee Arthroplasty 2:45 - 4:15 PM 4:30 - 5:30 PM Kappa Delta / OREF Paper Presentations 1:00 - 2:30 PM
