3/19/2016
Evaluation for Optical Performance of
Extended Depth of Focus Lens
using Optical Bench System
No Commercial Interest/
Relationship!!!
Geunyoung Yoon, PhD
Flaum Eye Institute, The Institute of Optics,
Biomedical Engineering, Center for Visual Science
University of Rochester
Presbyopia Correcting IOLs
Acknowledgement
Zonal
Asymmetric
Refractive Refractive
Len Zheleznyak, PhD
Scott MacRae, MD
Flaum Eye Institute,
University of Rochester
Choun-Ki Joo, MD
Young-Sik Yoo, MD
Department of Ophthalmology,
The Catholic University of Korea, Seoul, Korea
Jorge L. Alió, MD
Ophthalmology, Universidad Miguel Hernández,
Alicante, Spain
Presbyopia Correcting IOLs
ReZoom,
AMO
Mplus,
Oculentis
Diffractive
Bifocal
ReSTOR,
Alcon
+2.50D
+2.75D
Tecnis,
AMO
Low add power
Symfony,
AMO
Precizon,
Ophtec
EDoF
Chromatic aberration
control
Asymmetric
FineVision,
PhysIOL
AT Lisa,
Carl Zeiss
distance focus
near focus
Far
Near
McAlinden et al. (2011)
Gatinel et al. (2011)
Adaptive Optics Optical Bench Testing
Pupil size
control
Simulating cornea
aberration profile
ReSTOR,
Alcon
Tecnis,
AMO
Diffractive
Trifocal
MTF or
Halo testing
Defocus
ANSI model eye
1
3/19/2016
Through-focus Images
Defocus [D] :
-0.5
0
0.5
AcrySof monofocal
1.0
1.5
2.0
2.5
3.0
3.5
Single Value Image Quality Metric
4.0
4.5
5.0
Image-based 2-dimensional cross-correlation coefficient (2CC)
Reference
Image
Collected
Image
Metric
(2CC)
ReSTOR: +3D
AT LISA: +3.50D
Mplus: +2.75D
Extended Depth of Focus (EDoF) Design
Quantitative Defocus Curve
Spherical Aberration
As add power increases, intermediate
image quality decreases
1
0.9
0.8
0.7
0.6
0.5
0
2
0.65
0.6
0.55
2.5
4
0.8
Image Quality
Image Quality, 2CC
Lowest Intermediate
Image Quality
3mm
1
3
SA(µm) = 1.2
0.8
1.0
0.6
0.4
No SA
0.2
0.6
0.4
3.5
0.2
Add Power [D]
Defocus [D]
0
-4
AcrySof monofocal
ReSTOR 3D
Atlisa
Oculentis
-3
-2
-1
0
1
Near
Defocus [D]
Optical bench testing of presbyopia-correcting IOLs provides
a reliable prediction of improving patients’ through-focus
vision after IOL implantation.
2
Extended Depth of Focus (EDoF) IOLs
0.7
J of Refract Surg (2015)
0.6
Optical Image Quality
Mplus
(Oculentis)
ReStor
(Alcon)
Contrast
0.5
0.4
0.3
0.2
0.1
R2= 0.85
Finevision
(Physiol)
0
Infinity
100
66
50
40
33
Object Distance [cm]
Visual Acuity (LogMAR)
2
3/19/2016
Impact of IOL Decentration on
Distance Image Quality
Pupil-dependent Distance Image Quality
0.6
3 mm
4 mm
5 mm
0.5
0.5
0.25 mm
0.5 mm
0.75 mm
1 mm
0.4
0.4
0.35
Contrast
Contrast
0 mm
0.45
0.3
0.2
0.3
0.25
0.2
0.15
0.1
0.1
0.05
0
ReSTOR +2.5D
Tecnis ZKB00
Tecnis ZM900
Symfony
0
ReSTOR +2.5D
Distance Halo (3.0 mm pupil)
10 cd/m2
50 cd/m2
100 cd/m2
200 cd/m2
400 cd/m2
Tecnis ZKB00
Tecnis ZM900
+2.75D
+4.0D
Symfony
Distance Halo (5.0 mm pupil)
800 cd/m2
10 cd/m2
50 cd/m2
100 cd/m2
200 cd/m2
300 cd/m2
400 cd/m2
800 cd/m2
TECNIS monofocal
PRECIZON
ReSTOR +2.5 D
Mplus
TECNIS +2.75D
AT LISA Bifocal
TECNIS +4.00D
AT LISA Trifocal
TECNIS Symfony
Take Home Message
http://www.cvs.rochester.edu/yoonlab/
Optical bench testing assisted by image quality metric
provides quantitative defocus curves, representing
through-focus visual performance.
Extended depth of focus designs improve distance and
intermediate quality at the cost of near quality.
Lab Members:
Collaborators:
Antoine Barbot, PhD
Atanu Ghosh, PhD
Len Zheleznyak, PhD
Subam Basuthkar, OD, PhD
Dongjun Lee, MD
Ranjini Kottaiyan, OD
Olga Pikul, BS
Mengchen Xu, BS
HaeWon Jung, BS
Changsik Yoon, MS
Robert Dowd, BS
Dominique Noriega
Caeli Quiter
Keith Parkins, MS
Scott MacRae, MD
James Aquavella, MD
James Zavislan, PhD
Krystel Huxlin, PhD
Duje Tadin, PhD
Tara Vaz, OD
David Williams, PhD
Holly Hindman, MD
Rick Libby, PhD
Amy Lerner, PhD
Mike Buckley, PhD
Seth Pantanelli, MD
Ramkumar Sabesan, PhD
Perry Rosenthal, MD
Lynette Johns, OD
Deborah Jacobs, MD
Martin Banks, PhD
Myoung Joon Kim, MD
Ashutosh Richhariya, PhD
Ian Cox, OD, PhD
Shizuka Koh, MD, PhD
Jens Büehren, MD
Steve Park, MD
Choun-Ki Joo, MD
3