2nd AEGEAN HEMATOLOGY ONCOLOGY SYMPOSIUM “AHOS 2015” 17-20 September 2015, CHIOS - Hotel Chandris ORGANIZING COMMITTEE Evangelos Terpos (Co-chair) Guray Saydam (Co-chair) Ridvan Ali Seckin Cagirgan John Meletis Ilectra Papadimitriou Fahri Sahin Eleftherios Thiraios Theodoros P. Vassilakopoulos SCIENTIFIC COMMITTEE Ridvan Ali Seckin Cagirgan Meletios A. Dimopoulos Efstathios Kastritis Kostas Konstantopoulos Hayri Ozsan Panagiotis Panagiotidis Fahri Sahin Guray Saydam Evangelos Terpos Eleftherios Thiraios Mehmet Yilmaz ABSTRACT REVIEWERS Olga Meltem Akay Stavroula Giannouli Kostas Konstantopoulos Mehmet Yilmaz 3 EDITORIAL Dear Colleagues, It’s a privilege to invite you to the 2nd Aegean Hematology Oncology Symposium which will be held on 17-20 September 2015 in Chios. The Symposium is co-organized by the University of Athens (School of Medicine) and the Athens Medical Society in collaboration with the Turkish Medical Association of EHOD (Aegean Hematology Oncology Society). This meeting is planned to share country perspectives on hematology oncology topics between Greek and Turkish clinicians, to exchange experiences and to create the basis for multi-center, multi- national studies. During the last years, there was a significant progress in the biology of hematological malignancies that led to the development of several novel drugs in the field. The scientific program includes all these data presented by experienced hematologists and it is organized in well-balanced interactive sessions and teaching programs focusing on the needs of hematology/oncology clinicians. We selected Chios Island for this meeting due to its mutual historical and cultural background and its unique nature. We hope that you enjoy both the scientific program and the beauties of Chios and we thank you in advance for your contribution in the development of this meeting in order to be even better than the first one which was held in Athens in September 2014. On behalf of the Organizing Committee Evangelos Terpos & Guray Saydam Co-Chairs 4 17 SEPTEMBER 2015, THURSDAY 15:30-16:00 Registrations - Coffee 16:00-16:30 Opening Remarks Summary of the first AHOS in Athens 2014 Guray Saydam, TR Agenda of the second AHOS Evangelos Terpos, GR 16:30-18:30 SESSION 1: CHRONIC MYELOID LEUKEMIA Moderators: Ridvan Ali, TR - Anargyros Symeonidis, GR Lecture: Speaker: What is the optimal first-line therapy for CML? Panagiotis Panagiotidis, GR Lecture: Speaker: Mechanisms of resistance in CML Yusuf Baran, TR Debate: Can the CML patient Safely Stop TKI Therapy? Yes: No: Flora Kontopidou, GR Gulsum Emel Pamuk, TR 18:30-20:00 SESSION 2: ACUTE MYELOID LEUKEMIA Moderators: Cengiz Beyan, TR - Nora-Athina Viniou, GR Lecture: Speaker: Risk adapted AML therapy Panagiotis Tsirigotis, GR Lecture: Speaker: 7+3 standard treatment vs biologically based therapy Mahmut Tobu, TR Special Condition: AML therapy in the elderly patients (2 interesting cases) 1st Case: Dimitrios Christoulas, GR 2nd Case: Ozan Salim, TR 20:00 Opening Ceremony & Welcome Reception 5 18 SEPTEMBER 2015, FRIDAY 09:00-10:00 SESSION 3: ACUTE LYMPHOBLASTIC LEUKEMIA Moderators: Maria Angelopoulou, GR - Ahmet Ifran, TR Lecture: Speaker: Optimal therapy strategies in Ph+ ALL Mehmet Ali Ozcan, TR 2 Case Presentations Speaker: Ioannis Asimakopoulos, GR Speaker: Serkan Ocakci, TR 10:00-11:30 SESSION 4: HODGKIN’S LYMPHOMA Moderators: Stavroula Giannouli, GR - Levent Undar, TR Lecture: Speaker: Difficulties in the diagnosis of HL; the pathologist point of view Anna Tasidou, GR Lecture: Speaker: The role of interim PET/CT for treatment decisions in Hodgkin’s Lymphoma Theodoros Vassilakopoulos, GR Didactic lecture with a case: How should a young patient with Hodgkins Lymphoma relapsing after Auto-SCT be managed? Speaker: Mehmet Yilmaz, TR 11:30-12:00 Coffee Break 12:00-12:30 Special Lecture: How I manage low tumor burden Follicular Lymphoma Moderators: Gulsum Ozet, TR - Panagiotis Tsirigotis, GR Speaker: Inci Alacacioglu, TR 12:30-13:15 Satellite Lecture (sponsored by ROCHE HELLAS) Moderator: Evangelos Terpos, GR Lecture: Speaker: Anti-CD20 Αntibodies Continue to Improve Outlook in CLL and NHL Maria Angelopoulou, GR 6 18 SEPTEMBER 2015, FRIDAY 13:15-14:00 Satellite Lectures (sponsored by NOVARTIS) Treating Multiple Myeloma beyond IMiDs & Proteasome Inhibitors Moderator: Evangelos Terpos, GR Lecture: Speaker: Game of clones: The importance of epigenetics in treating a clonal disease Eleftheria Hatzimichael, GR Lecture: Speaker: Clinical importance of epigenetic targeting in MM Eirini Katodritou, GR 14:00-15:30 Lunch Break 15:30-17:00 Poster Session: Poster View and Discussion Moderators: Guchan Alanoglu, TR - Volkan Karakus, TR - Anil Tombak, TR 17:00-18:30 SESSION 5: MYELOPROLIFERATIVE NEOPLASMS Moderators: Osman Ilhan, TR - Panagiotis Panagiotidis, GR Lecture: Speaker: MPN classification and diagnosis Damianos Sotiropoulos, GR Lecture: Speaker: JAK2 inhibitors Era: Optimization of MPN Treatment Hayri Ozsan, TR 2 Case Presentations Speaker: Filiz Vural, TR Speaker: Konstantina Papaioannou, GR 18:30-20:00 Satellite Symposium: Hematological Malignancies: Old diseases, new targets (sponsored by JANSSEN CILAG) Moderator: Evangelos Terpos, GR Lecture: Speaker: Multiple Myeloma (ΜΜ) Sosanna Delimpasi, GR Lecture: Speaker: Chronic Lymphocytic Leukemia (CLL) Sotirios Sachanas, GR Lecture: Speaker: Mantle Cell Lymphoma (ΜCL) Maria Dimou, GR 7 19 SEPTEMBER 2015, SATURDAY 09:00-10:30 SESSION 6: B-CELL LYMPHOMAS Moderators: Zahit Bolaman, TR - Gerassimos A. Pangalis, GR Debate: Should an asymptomatic patient with low-tumor-burden nonfollicular indolent lymphomas be observed or have immediate treatment? Observation only until disease progression Marie-Christine Kyrtsonis, GR Immediate treatment Olga Meltem Akay, TR Lecture: Speaker: Is R-CHOP the standard treatment for high-risk diffuse large B-cell lymphoma? Burhan Ferhanoglu, TR 10:30-11:00 Special Lecture: MDS/MPN Syndromes Moderators: Vasiliki Pappa, GR - Ali Unal, TR Speaker: Nora - Athina Viniou, GR 11:00-11:30 Coffee Break 11:30-14:30 Poster Session: Poster View and Discussion Moderators: Cengiz Ceylan, TR - Oktay Bilgir, TR 14:30-17:00 Lunch Break 17:00-17:45 Satellite Lecture (sponsored by AMGEN HELLAS) Moderator: Evangelos Briasoulis, GR Lecture: Speaker: New Proteasome Inhibitors in the Treatment of Relapsed Multiple Myeloma Anargyros Symeonidis, GR 17:45-18:30 Invited speaker by the co-chairs Moderators: Evangelos Terpos, GR - Guray Saydam, TR Lecture: Speaker: 8 Novel Therapies for Multiple Myeloma Meletios - Athanasios Dimopoulos, GR 19 SEPTEMBER 2015, SATURDAY 18:30-20:00 Satellite Symposium: Changing the treatment paradigm in MM & MDS with disease modifying agents (sponsored by GENESIS PHARMA) Moderator: Nikolaos Anagnostopoulos, GR Lecture: Speaker: Maximizing the benefits of Lenalidomide in Multiple Myeloma Athanasios Zomas, GR Lecture: Speaker: The role of Lenalidomide in the treatment of MDS Alexandra Kourakli, GR Lecture: Speaker: Therapeutic options in High risk MDS Vasiliki Pappa, GR 20 SEPTEMBER 2015, SUNDAY 08:30-10:00 SESSION 7: MULTIPLE MYELOMA AND OTHER PLASMA CELL NEOPLASMS Moderators: Seckin Cagirgan, TR - Kostas Konstantopoulos, GR Lecture: Speaker: Lecture: The novel criteria for the definition of Symptomatic multiple Myeloma; Do we need more? Eirini Katodritou, GR Speaker: Management of Newly Diagnosed Myeloma Patients who Are Eligible for Autologous Transplantation Tulin Firatli Tuglular, TR Lecture: Speaker: Systemic AL-amyloidosis Efstathios Kastritis, GR 10:00-12:00 INTERESTING CASES IN LYMPHOPROLIFERATIVE AND PLASMA CELL NEOPLASMS Moderators: Birol Guvenc, TR - Marie-Christine Kyrtsonis, GR Case Presentation Speaker: Anil Tombak, TR Case Presentation: Patient with relapsed AL amyloidosis and renal impairment Speaker: Maria Gavriatopoulou, GR Case Presentation Speaker: Ahmet Ifran, TR Case Presentation: Patient with relapsed Waldenstrom’s Macroglobulinemia after 3 prior lines of therapy Speaker: Eftychia Kafantari, GR 12:00 Closing Remarks and Best Poster Awards Fahri Sahin, TR - Evangelos Terpos, GR 9 THANKS TO OUR SPONSORS 10 FACULTY Alacacioglu Inci Associate Professor of Hematology, Dokuz Eylül University, School of Medicine, Izmir-Turkey Assistant Professor of Hematology, Suleyman Demirel University, School Alanoglu Guchan of Medicine, Isparta-Turkey Professor of Hematology, Uludag Unıversity, School of Medicine, Bursa-Turkey Ali Ridvan Assistant Professor of Hematology, National and Kapodistrian University Angelopoulou Maria of Athens, School of Medicine, Athens-Greece Anagnostopoulos Nikolaos Director, Department of Hematology, ”Georgios Gennimatas” General Hospital, Athens-Greece Department of Hematology, Laikon General Hospital, Athens-Greece Asimakopoulos Ioannis Professor of Molecular Biology, Abdullah Gül University, Kayseri-Turkey Baran Yusuf Professor of Hematology, Gülhane Military Medical Academy, Ankara-Turkey Beyan Cengiz Associate Professor of Hematology, Bozyaka Education and Research Bilgir Oktay Hospital, Izmir-Turkey Professor of Hematology, Adnan Menderes University, School of Bolaman Zahit Medicine, Aydin-Turkey Professor of Oncology, Director, Department of Hematology, University Briasoulis Evangelos Hospital of Ioannina, Ioannina-Greece Professor of Hematology, Izmir University, Medicalpark Hospital, IzmirCagirgan Seckin Turkey Associate Professor of Hematology, Tepecik Education and Research Ceylan Cengiz Hospital, Izmir-Turkey Consultant Hematologist, Department of Hematology, 251 General AirChristoulas Dimitrios Force Hospital, Athens-Greece Consultant Hematologist, Department of Hematology & Bone Marrow Delimpasi Sosanna Transplantation Unit,‘Evangelismos’ General Hospital, Athens - Greece Minister of Health; Rector of the National and Kapodistrian University of Dimopoulos Meletios Athens; Professor of Hematology Oncology, National and Kapodistrian Athanasios University of Athens, School of Medicine, Athens-Greece Consultant Hematologist, First Department of Propedeutic Internal Dimou Maria Medicine, ‘Laiko’ General Hospital, Athens-Greece Professor of Hematology, Koc University, School of Medicine, IstanbulFerhanoglu Burhan Turkey Hematology Oncology Unit, Department of Clinical Therapeutics, Gavriatopoulou Maria National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Professor of Hematology, Cukurova University, School of Medicine, Guvenc Birol Adana-Turkey Assistant Professor of Hematology, National and Kapodistrian University Giannouli Stavroula of Athens, School of Medicine, Athens-Greece Consultant Hematologist, Department of Hematology, University Hospital of Hatzimichael Eleftheria Ioannina, Ioannina-Greece Associate Professor of Hematology, Bayindir Hospital, Ankara-Turkey Ifran Ahmet 11 FACULTY Ilhan Osman Kafantari Eftychia Karakus Volkan Kastritis Efstathios Katodritou Eirini Konstantopoulos Kostas Kontopidou Flora Professor of Hematology, Ankara University, School of Medicine, AnkaraTurkey Hematology Oncology Unit, Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Specialist in Hematology, Mugla Sitki Kocman University, School of Medicine, Mugla-Turkey Assistant Professor of Medical Oncology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Director, Department of Hematology, Theageneio Cancer Hospital, Thessaloniki-Greece Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Assistant Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Kourakli Alexandra Director, Hematology Division, Department of Internal Medicine, University Hospital of Patras, Patras-Greece Kyrtsonis Marie-Christine Assistant Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Professor of Hematology, Osmangazi University, Eskisehir-Turkey Assistant Professor of Hematology, Izmir University, Medicalpark Hospital, Izmir-Turkey Professor of Hematology, Dokuz Eylül University, School of Medicine, Izmir-Turkey Professor of Hematology, Yildirim Beyazit University, Ankara-Turkey Professor of Hematology, Dokuz Eylül University, School of Medicine, Izmir-Turkey Professor of Hematology, Trakya University, School of Medicine, EdirneTurkey Vice President of the Hellenic Society of Hematology, Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Professor of Hematology, Department of Hematology, Athens Medical Center, Psychicon Branch, Athens-Greece Hematology Laboratory, Alexandra General Hospital, Athens-Greece Assistant Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Consultant Hematologist, Department of Hematology, Athens Medical Center, Psychicon Branch, Athens-Greece Associate Professor of Hematology, Ege University, School of Medicine, Izmir-Turkey Akay Olga Meltem Ocakci Serkan Ozcan Mehmet Ali Ozet Gulsum Ozsan Hayri Pamuk Gulsum Emel Panagiotidis Panagiotis Pangalis Gerassimos A. Papaioannou Konstantina Pappa Vasiliki Sachanas Sotirios Sahin Fahri 12 FACULTY Salim Ozan Assistant Professor of Hematology, Akdeniz University, School of Medicine, Antalya-Turkey Professor of Medicine and Chair Dept. of Hematology Ege Saydam Guray University Hospital, Izmir-Turkey Director Hematologist, Department of Hematology & Bone Marrow Sotiropoulos Damianos Transplantation Unit, “Papanikolaou” General Hospital, ThessalonikiGreece Professor of Hematology, University of Patras, School of Medicine, Symeonidis Anargyros Patras-Greece Director, Hemopathology Laboratory, Evangelismos Hospital, AthensTasidou Anna Greece Associate Professor of Hematology, National and Kapodistrian University Terpos Evangelos of Athens, School of Medicine, Athens-Greece Professor of Hematology, Ege University, School of Medicine, IzmirTobu Mahmut Turkey Assistant Professor of Hematology, Mersin University, School of Tombak Anil Medicine, Mersin-Turkey Assistant Professor of Hematology, National and Kapodistrian University Tsirigotis Panagiotis of Athens, School of Medicine, Athens-Greece Professor of Hematology, Marmara University, Istanbul-Turkey Tuglular Tulin Firatli Professor of Hematology, Erciyes University, School of Medicine, KayseriUnal Ali Turkey Professor of Hematology, Akdeniz University, School of Medicine, Undar Levent Antalya-Turkey Vassilakopoulos Theodoros Assistant Professor of Hematology, National and Kapodistrian University of Athens, School of Medicine, Athens-Greece Professor of Hematology, Ege University, School of Medicine, IzmirVural Filiz Turkey Assistant Professor of Hematology, National and Kapodistrian University Viniou Nora - Athina of Athens, School of Medicine, Athens-Greece Professor of Hematology, Gaziantep University, School of Medicine, Yilmaz Mehmet Gaziantep-Turkey Zomas Athanasios Director, Department of Hematology, ”Agioi Anargyroi” General Cancer Hospital, Kifisia-Greece 13 GENERAL INFORMATION 2nd AEGEAN HEMATOLOGY ONCOLOGY SYMPOSIUM (AHOS 2015) VENUE LOCATION & DATES The 2nd AHOS 2015 will be held from Thursday, September 17th to Sunday, September 20th 2015 in Chios, at Hotel Chios Chandris, www.chandris.gr REGISTRATION - CERTIFICATE OF ATTENDANCE - CREDITS All registered participants are entitled to receive a Certificate of Attendance. The Certificate will be issued only upon display of participant badge, which will be issued by the Symposium secretariat and only upon satisfactory attendance. The Symposium is accredited with 18 CME credits by the Panhellenic Medical Association. OFFICIAL LANGUAGE The official language of the course is English. EXHIBITION The Symposium will be accompanied by a major exhibition where pharmaceutical and/or equipment/device industries will display relevant products and therapeutic developments. ORGANIZING SECRETARIAT Congress World Event - Travel 14 Congress World, Event - Travel L.O.V.I., Tourism & Organization 23 Meandrou str., 115 28 Athens, + 30 210 7222 518, +30 210 7210 069 www.congressworld.gr, ap@congressworld.gr Ali Çetinkaya Bulvarı No:68 Doktorlar Sitesi D:202 Alsancak - Konak / İzmir 0090 232 465 18 88 www.loviturizm.com onur@loviturizm.com 15 REV/MM/HEMA/KTX/07.2014 Περαιτέρω πληροφορίες διατίθενται από τη Γένεσις Φάρμα Λ. Κηφισίας 274, 152 32 Χαλάνδρι Τηλ.: 210 8771500, Fax: 210 6896619 e-mail: info@genesispharma.com, www.genesispharma.com