Journal of Management Engineering and Information Technology (JMEIT) Volume -3, Issue- 1, Feb. 2016, ISSN: 2394 - 8124 Website: www.jmeit.com | E-mail: editorjmeit@outlook.com|jmeit@outlook.com Medical Monitoring: Empowered By Integrated Analog Technology Vijay Laxmi Kalyani, Surbhi Khandelwal, Vaishali Kalal Vijay Laxmi Kalyani, Assistant professer, ECE Department, Govt. Women Engineering College, Ajmer vijaylaxmikalyani@yahoo.com Surbhi Khandelwal, B.Tech. III year, ECE branch, Govt. Women Engineering College, Ajmer surbhik101@gmail.com Vaishali Kalal, B.Tech. III year, ECE branch, Govt. Women Engineering College, Ajmer vaishalikalal87@gmail.com Abstract: In developed and developing nations alike the demand for medical monitoring is growing. As the need for care grows, the technology plays an important role in patient care. In this paper, author emphasizes on the importance of integrated analog components in presently using medical monitoring devices. Analog devices technology and design solutions are helping to shape the future of healthcare diagnosis ,clinical monitoring equipment .Integrated analog components like, smart sensors, AD8232, ADAS1000, PPG (photoplethysmogram), LED’s, A/D Convertor ,are used in medical monitoring devices. These integrated analog components are playing critical role in rapidly evolving market like miniaturization, portability, material compliance (accuracy). Keywords: AD8232, ADAS1000, electronic pills, PPG, LED’S, smart sensors. I. INTRODUCTION As humans, we perceive the world in analog. Everything we see and hear is a continuous transmission of information to our senses. This continuous stream is what defines analog data. Analog devices are the combination of machines and components that work in a linear manner, often with an ability to make a continuous change .When all analog components are fabricated on a single chip, it is known as integrated analog device. In this paper, author(s) wants to describe the use of integrated analog components in medical monitoring devices. II. INTEGRATED ANALOG COMPONENTS Some integrated analog components are smart sensors, electronic pills, AD8232, PPG, LED’S, ADAS1000 etc. These integrated analog components are playing a critical role in rapidly evolving market like miniaturization, portability, accuracy. These integrated analog components are used in cardiac monitoring, respiratory monitoring ,hemodynamic monitoring ,neurological monitoring etc. II.I. SMART SENSORS: Sensors are used in electronicsbased medical equipments to detect and respond to input electrical signals. Sensors enable new types of monitoring to support more independent patient lifestyles. Smart sensors are the sensors, which are sophisticated, small, robust, and don't consume a lot of power. They are natural choice in medical equipment design, particularly in smaller, portable, noninvasive equipments. For long term care purpose, patients need to be monitored on the locations other than hospitals. Fig.1: Block diagram of Smart sensors II.I.I. Smart Sensors and its applications 1. Pressure sensors Pressure sensors is a device which generates electrical signals according to applied pressure, so it works as a pressure transducer. Pressure sensors are used in blood pressure cuffs, sleep apnea detection, respirometers, anesthetic control, air concentration, implanted cardiac measurement, gastrointestinal pressure sequencing etc[1]. Fig.2: Pressure sensor Source: https://www.google.co.in/search?q=pressure+sensors 2. Temperature sensors Temperature sensors provide safety against extreme heat, hazards, staying within certain range. It enhances the circuit stability in excess heat condition by reducing the temperature of the device or shut down the device to avoid disasters. Temperature sensors are used in blood temperature monitoring, ablation temperature monitoring, respiratory air temperature monitoring, humidified oxygen heater temperature monitoring and control, incubators, patient warming, endovascular cooling sensors, fast response USB digital thermometers, organ transplant system temperature monitor and control, thermography temperature probes and gas flow detection temperature sensors[2]. Fig 3: Temperature sensor Source: https://www.google.co.in/search?q=temperature+sensors 3. Flow Sensors All rights reserved © www.jmeit.com Journal of Management Engineering and Information Technology (JMEIT) Volume -3, Issue- 1, Feb. 2016, ISSN: 2394 - 8124 Website: www.jmeit.com | E-mail: editorjmeit@outlook.com|jmeit@outlook.com pressure as a disposable sensor, to measure intrauterine It is the device which senses and record the rate of fluid flow. pressure during birth, to monitor patient’s vital signs in It is used in anesthesia delivery machines, oxygen hospitals and ambulances, to monitor patient breathing, in concentrators, sleep apnea machines, ventilators, respiratory eye surgery to control the vaccum level, in kidney dialysis to monitoring, gas mixing, and electro-surgery. dessication, or monitor the inlet and outlet pressures of the blood, in drug destroy tissue such as tumors. infusion pumps to monitor the flow rate. Fig 4: Flow sensor Source: https://www.google.co.in/search?q=flow+sensors Fig 7: MEMS Sensors Source: https://www.google.co.in/search?q=MEMS+sensors 4.IMAGE SENSORS Image sensors are used to see image of entire small intestine which can help in colon cancer detection. Image sensor applications include radiography, fluoroscopy, cardiology, mammography, dental imaging, endoscopy, external observation, minimally invasive surgery, laboratory equipment, ocular surgery and observation, and artificial retinas. II.II. ELECTRONIC PILL Fig 5: Image sensor using retina’s image Fig 8: Microelectronic pill Source: https://www.google.co.in/search?q=image+sensors Source:https://www.google.co.in/search?q=electronic+pills+in+me dical+monitoring 5. BIOSENSORS Biological sensor is made up of biological elements. The biological element (may be enzyme, antibody or nucleic acid) interacts with analyte (a substance, whose constituents are to be measured) and the biological signal is converted into electrical signal. It is used in blood glucose, cholesterol testing, testing for drug misuse. Also it is used in general healthcare monitoring, screening for diseases, clinical analysis and diagnosis of disease, veterinary and agricultural applications, industrial processing and monitoring, environmental pollution control [3]. Fig 6: Bio sensors measuring blood glucose Source: https://www.google.co.in/search?q=bio+sensors When electronic pills travel through the body, it captures the information like acidity, pressure, temperature levels, images of esophagus through its tiny camera. II.II. AD8232 It is an integrated signal conditioning block for ECG use to extract, amplify and filter small biopotential signals in presence of noisy conditions, created by motion of electrode’s placement. The AD8232 is an analogue ECG amplifier used for low power and body worn applications [4].The measurement of electrical activity of heart can be done by ECG (electrocardiogram) also, but in some conditions, ECG may be extremely noisy. The AD8232 Single Lead Heart Rate Monitor acts as an op amp to help obtain a clear signals without noise. Operating voltage of AD8232 is -3.3V. AD8232 is used in remote health monitoring, biological signal collection, fitness and exercise heart rate monitoring ,portable ECG. 6. MEMS sensors The intelligent devices which are connected with MEMS sensors alert medical professionals when elderly patients suffer serious injuries from unobserved fall and if the GPS system is connected with the device, then it will provide location information also. MEMS sensors collect the information from the body such as temperature, dissolved oxygen level and ph level by sampling the body fluid. MEMS sensors are used in ICU (intensive care unit) to monitor blood All rights reserved © www.jmeit.com Journal of Management Engineering and Information Technology (JMEIT) Volume -3, Issue- 1, Feb. 2016, ISSN: 2394 - 8124 Website: www.jmeit.com | E-mail: editorjmeit@outlook.com|jmeit@outlook.com Fig 9: AD8232 single lead heart rate monitor II.IV. LED’S Another technique for ECG measurement is ADAS1000, which is also used for respiration. The ADAS1000 is designed to simplify the task of acquiring and ensuring quality ECG signals. Its low power and small size make it suitable for portable, battery powered applications. The high performance also makes it suitable for higher end diagnostic machines. It is used in respiration measurement, pace detection, measurement of ECG signals, bed side patient monitoring, cardiac defibrillators, patient transport stress testing, to measure thoracic impedence. Fig 10: circuit operation of PPG There are various benefits of using LEDs for medical applications including longer life, less heat, dynamic control, lower energy consumption, and in many cases, lower cost. LED’S are used in surgical lighting, exam lights, photodynamic therapy, and endoscopy in current integrated analog devices. II.IV.I. Applications of LED’S 1.Photodynamic therapy is a cancer treatment method ,that recently has been improved using LED’S. The photosensitiser is inserted into the patient’s veins, it accumulates into tumor cell and then it is activated through light source and tumor is destroyed which results in free radical generation followed by cell death. Fig 12: Photodynamic therapy source:https://www.google.co.in/search?q=CIRCUIT+OPERATIO N+OF+ADAS1000 2. Endoscopy It is used to examine the interior of a hollow organ or cavity of the body. In endoscopy surgical instruments are inserted into the body through a cut. The area of interest within the body is illuminated using a small diameter fiber bundle that is inserted along with the surgical tools. II.III. PPG By illuminating the light on body using LED (light emitting diode), PPG measures the heart rate with light absorption, which is either transmitted or reflected using pulse oximeter. The waveforms of PPG varies with location and also with the orientation of pulse oximeter. It is used to monitor breathing, to measure hypovolemia, to measure circulatory conditions, to measure oxygen saturation in blood(spo2), also used for volumetric measurement of an organ. Fig 13: Endoscopy Source: http://www.wisegeekhealth.com/ 3. Surgical light It is also known as an operating light or surgical lighthead. It is a medical device intended to assist medical staff during a surgical procedure by illuminating a local area or cavity of the patient. A combination of several surgical lights is known Fig 11: Block diagram of PPG wristband device All rights reserved © www.jmeit.com Journal of Management Engineering and Information Technology (JMEIT) as a Volume -3, Issue- 1, Feb. 2016, ISSN: 2394 - 8124 Website: www.jmeit.com | E-mail: editorjmeit@outlook.com|jmeit@outlook.com electrons, but also to photons and convert either from “surgical light system” optical to electrical, or electrical to optical, or indeed both. Phototherapeutic or light therapy innovation is the latest application of optoelectronics. The field of phototherapeutics, or light therapy, involves exposure to light of different wavelengths. This may be very specific in some cases, or full spectrum in others. Fig 16: optoelectronic device III.II. Phototherapy Fig 14: LED light is integrated into surgical light Source: https://www.google.co.in/search?q=SURGICAL+LIGHT 4. Exam lights Exam lights are used for careful examination of patients. A well illuminated environment improves visibility. All patient exam room lights are finely crafted and durable to withstand repeated use. Depending on specific needs, these patients exam room lights can be used in dermatology, plastic surgery or general practice. It is used to treat acne, sleep problems, seasonal affective disorder (SAD) and minor bacterial and viral conditions. Phototherapeutic techniques are now being used in an increasing number of cosmetic procedures, such as wrinkles, warts, skin rejuvenation and tightening. III.III. Portal technology Portal technology allows physicians and patients to access medical records and interact online. Through this technology patients become more closely involved and better educated about their care. III.IV. In medical monitoring, ultra thin sheets of LED’S and photodetectors are inserted into the body to activate photosensitive drugs. IV. CONCLUSION Fig 15: exam light Source: http://www.amico.com/products/lightning-solutions III. ADVANCEMENTS IN MEDICAL MONITORING DEVICES USING INTEGRATED ANALOG COMPONENTS This paper provided a brief introduction to MEDICAL MONITORING DEVICES like LED’S,ADC Convertors, Smart sensors,AD8232 Etc and its advancement in future direction .It has also described about leading technologies, identify no. of the opportunities ,as well as some of the associated challenges. We have reached a point where wearable medical devices can be designed, built and sold cheaply enough to improve our quality of life. One of the reasons this is possible is sensor technology. It is not a new concept, people in the country are using this technologies. The purpose of this study is to make people aware about the leading technologies and advancement in technologies. III.I. Optoelectronic devices Applications of optoelectronics are continuously increasing. The partnership of technology and light inspired the creation of optoelectronics. It is used for the emission, manipulation and detection of light. It make use of effect of light on semiconducting materials. They respond not only to V. REFERENCES 1. By Robert guzlak “The role of pressure sensors in medical devices”, sr. Engineering Manager and Lori Appel-Manager, Marketing Communications, kavilo All rights reserved © www.jmeit.com Journal of Management Engineering and Information Technology (JMEIT) Volume -3, Issue- 1, Feb. 2016, ISSN: 2394 - 8124 Website: www.jmeit.com | E-mail: editorjmeit@outlook.com|jmeit@outlook.com 2. https://www.thermistor.com/medical-temperature-sensors 3.http://www.news-medical.net/health/biosensorapplications.aspx 4. www.mouser.in/..adi-ad8232-amplifier/ VI. Author’s Details Vijay Laxmi Kalyani is currently working as assistant professor in the department of ECE in GWECA, Ajmer. She has attended various workshops, conferences, FDP,STC and also published various research papers in various international journals and conferences, Member-IAENG. Surbhi Khandelwal is pursuing B.Tech.(3rd year) in Electrical AND Electronics Engineering in GWEC, Ajmer. Vaishali Kalal is pursuing B.Tech.(3rd year) in Electronics and communication Engineering in GWEC, Ajmer. All rights reserved © www.jmeit.com