Puros Demineralized Bone Matrix (DBM)
®
DBM with Reverse Phase Medium (RPM) – Putty, Putty with Chips, Gel and Paste
DBM – Block and Strip
Puros DBM Block
Puros DBM Strip
Puros DBM with RPM Putty
Puros DBM with RPM Putty with Chips
Puros DBM with RPM Gel
Puros DBM with RPM Paste
Safe and effective bone graft substitutes to
stimulate natural bone formation processes
Used alone or as a bone graft extender, Puros DBM allografts provide
osteoconductive and osteoinductive properties, superior handling and
excellent graft containment in a ready to use application.
Puros
®
Demineralized Bone Matrix
Block and Strip
Puros Demineralized Bone Matrix (DBM)
Block and Strip are unique bone graft substitutes
composed of 100% demineralized cancellous bone.
Puros DBM Block and Strip cancellous bone allografts
are ideal natural scaffolds for new bone growth because
they are processed to retain osteoinductive properties
by preserving endogenous growth factors including
BMP 2, BMP 4 and BMP 7 to help support new
bone formation.1
Puros DBM Block and Strip are available in a variety of
configurations to minimize the need for shaping during
the surgical procedure, and are conveniently provided
sterile with up to five year shelf life at room temperature.
Puros DBM Block and Strip
Product Attributes:
• Osteoconductive
• O
steoinductive properties including endogenous
growth factors BMP 2, BMP 4 and BMP 7 to help
stimulate new bone formation1
• D
emineralized cancellous bone – no carrier or
binding agent
Puros DBM Strip used with Trabecular Metal™
Material, TM-400 Device
• A
vailable in a variety of sizes and shapes to
reduce transplant preparation
• Flexible and compressible once wetted
Excellent blood wicking capabilities (after minimal preparation)
1. Shi Y., Dittman B., Atkinson B. (2011) Bone Morphogenic Protein (BMP) Content in Cancellous Bone: A Suitable Substrate For Allograft Stem Cells. AlloSource Scientific Data Series 4, 3.
Puros
®
Demineralized Bone Matrix with Reverse Phase Medium
Putty and Putty with Chips
Puros Demineralized Bone Matrix with Reverse
Phase Medium (DBM with RPM) Putty, Putty with
Chips, Gel and Paste are unique bone graft substitutes
composed of demineralized bone matrix in a reverse phase
medium. Puros DBM with RPM products are designed to
stimulate natural bone formation processes, in which
mesenchymal cells differentiate into bone-forming cells.
Because the reverse phase medium becomes more
viscous at warm temperatures, it allows the allograft to
be malleable at operating room temperatures, but causes
the product to stiffen when placed in the operative site.
Thus, the DBM is contained at the surgical site with
minimal loss through irrigation and suction.
Variability in allograft tissue is always a concern as no
two donors are alike, which is why Zimmer utilizes
a highly regarded in-vivo test to confirm osteoinductive
potential of every lot ensuring the ability to grow new
bone. Additionally, all lots are tested for osteoinductive
potential after sterilization.
Puros DBM with RPM Putty and
Putty with Chips Product Attributes:
• Provides excellent source of OI material for fusions
• Safe and regulated
• Superior handling and graft containment
• More viscous at body temperature
• Resists irrigation
• Lot tested for OI potential after sterilization
Resists irrigation
Puros DBM with RPM Putty with Chips contains
(850 microns to 4mm) cancellous bone chips.
Puros
®
Demineralized Bone Matrix with Reverse Phase Medium
Gel and Paste with Cancellous Bone
Puros DBM with RPM Gel and
Paste Product Attributes:
• E
nhances flow through carrier syringe
to fusion site
• Easily molded to desired shape
• Will not stick to surgical gloves
• Hardens at body temperature
• Remains in surgical site
• Resists irrigation
Puros DBM with RPM Paste contains added ground
cancellous bone (<500 microns) to provide additional
structural properties for bone growth.
Autograft
Why Use Puros DBM with RPM?
Pre-clinical evidence suggests that Puros DBM
with RPM Gel may provide a suitable alternative
to autograft for routine bone grafting procedures,
and facilitate fusion with normal bone.2, 3
6 weeks
12 weeks
26 weeks
AlloFuse®*
Radiographs show bone formation at
the 12 and 26 week time points for both
the autograft and DBM specimen 2
6 weeks
12 weeks
26 weeks
* Puros DBM with RPM is a product that is comprised of the same components and formulation as AlloFuse.
2. Russel, N., Walsh, W.R., Oliver, Y., Bell, D.J., and Pak, P. Demineralized Bone Matrix Provides Equivalent Results to Autograft in Standard
Posterolateral Fusion Model in Adult Rabbits. Zimmer Spine white paper, ZS-SA0799 Rev. A (11/13).
3. Coetzee, J., Use of Demineralized Bone Matrix Gel in Foot Surgery: A Prospective Randomized Controlled Study Comparing Demineralized Bone
Matrix to Autologous Bone Graft. Zimmer Spine white paper, ZS-SA0800 Rev. A (11/13).
Puros DBM Block and Strip
Puros DBM with RPM Putty
and Putty with Chips
Puros DBM with RPM Gel and
Paste with Cancellous Bone
Item Number
Description
Item Number
Description
Item Number
Description
61515012
Block, 12mm x 12mm x 12mm
84038001
Putty, 1.0cc
84138001
Gel, 1.0cc
61515014
Block, 14mm x 14mm x 14mm
84038002
Putty, 2.5cc
84138005
Gel, 5.0cc
61615154
Strip, 15mm x 40mm x 3 - 6mm
84038005
Putty, 5.0cc
84138010
Gel, 10.0cc
61615251
Strip, 20mm x 50mm x 3 - 6mm
84038010
Putty, 10.0cc
84238001
Paste with Cancellous, 1.0cc
61615205
Strip, 20mm x 50mm x 3 - 6mm (2 pack)
84338005
Putty with Chips, 5.0cc
84238003
Paste with Cancellous, 3.0cc
84338010
Putty with Chips, 10.0cc
84238008
Paste with Cancellous, 8.0cc
Disclaimer:
This documentation is intended exclusively for physicians and is not intended for laypersons.
Information on the products and procedures contained in this document is of a general nature and does not represent and
does not constitute medical advice or recommendations. Because this information does not purport to constitute any diagnostic
or therapeutic statement with regard to any individual medical case, each patient must be examined and advised individually,
and this document does not replace the need for such examination and/or advice in whole or in part.
Please refer to the package inserts for important product information, including, but not limited to, indications,
contraindications, warnings, precautions and adverse effects.
Caution: Federal (USA) law restricts this device to sale by or on the order of a physician. Please see the product Instructions
for Use for a complete listing of the indications, contraindications, warnings, precautions and adverse effects.
Printed in U.S.A. Subject to change without notice.
Contact your Zimmer Spine representative or visit us at www.zimmerspine.com
Distributed by:
Zimmer Spine
7375 Bush Lake Road
Minneapolis, MN 55439
800.655.2614
Manufactured by:
AlloSource
6278 South Troy Circle
Centennial, CO 80111
800.557.35870559
zimmerspine.com
AlloFuse is a registered trademark of AlloSource.
ZS-SA0796 Rev. B (851S-1007-00)
© 2014 Zimmer Spine, Inc. (01/14)