Scheme & Syllabi
M.Tech. (Biomedical Engineering)
w.e.f. 2013-2014
Department of Biomedical Engineering
Guru Jambheshwar University of Science & Technology, Hisar
1
Scheme of M.Tech. (Biomedical Engineering)
M.Tech. (Semester 1)
Code
BME-711
BME-712
BME-713
BME-714
BME-715
BME-716
BME-717
Total
Subject
L
Anatomy and Physiology
Biomedical Sensors and Transducers
Biomedical Signal Conditioning
Biomedical Equipments
Biomaterials and Artificial Organs
Biomedical Sensors and Transducers
Lab.
Biomedical Equipments Lab.
T
P
Credit
Marks of evaluation
Internal
External
Total
3
4
4
4
3
-
2
0
0
0
2
-
4
4.0
4.0
4.0
4.0
4.0
2.0
30
30
30
30
30
30
70
70
70
70
70
70
100
100
100
100
100
100
18
4
4
8
2.0
24
30
210
70
490
100
700
L
T
P
Credit
M.Tech. (Semester 2)
Code
BME-721
BME-722
BME-723
BME-724
BME *
BME-725
BME-726
Total
Subject
Biomedical Image Processing
Biomedical Signal Processing
Biomechanics
Diagnostic Imaging and Radiation
Biology
Elective-I
Biomedical Signal and Image
Processing Lab.
Biomedical Signal Conditioning Lab.
Marks of evaluation
Internal
External
Total
4
4
3
3
0
0
2
2
-
4.0
4.0
4.0
4.0
30
30
30
30
70
70
70
70
100
100
100
100
4
-
0
-
4
4.0
2.0
30
30
70
70
100
100
18
4
4
8
2.0
24
30
210
70
490
100
700
M.Tech. (Semester 3)
Code
BME *
BME *
BME-731
BME-732
Subject
Elective-II
Elective-II
Seminar
Dissertation Phase-I
Total
L
T
P
Credit
Marks of evaluation
Internal
External
Total
4
4
-
0
0
-
4
6
4.0
4.0
2.0
3.0
30
30
100
100
70
70
---
100
100
100
100
8
0
10
13.0
260
140
400
L
T
P
Credit
Marks of evaluation
9.0
9.0
Internal
---
M.Tech. (Semester 4)
Code
BME-741
Total
Subject
Dissertation Phase-II
-
-
18
18
External
100
100
Total
100
100
2
Subject code for electives:
Sr. no.
Code
1
2
3
4
5
BME-761
BME-762
BME-763
BME-764
BME-765
1
2
3
4
BME-771
BME-772
BME-773
BME-774
1
2
3
4
5
BME-775
BME-776
BME-777
BME-778
BME-779
Semester 1
Semester 2
Semester 3
Semester 4
Total credit
Subject
Elective-I
Bioethics, IPR and Standards
Rehabilitation Engineering
Fiber Optics and LASER for Medical Applications
Design Principles for Medical Systems
Drug Delivery systems and Implantable Devices
Elective-II
Telemedicine
Embedded Systems in Medicine
MEMS and Medical Applications
Physiological Control Systems
Elective-III
Biomedical Waste Management
Artificial Intelligence and Expert Systems
Nanotechnology for Biomedical Applications
Tissue Engineering
Sports and Biomedical Engineering
24
24
13
09
70
Note: Teaching load of two hours will be assigned per week per student to the supervisor for
Dissertation phase-I and phase-II.
3
M.Tech. (Biomedical Engineering)
Semester -1
4
BME – 711: Anatomy and Physiology
M. Tech. (Semester – 1)
L
3
T
2
P
-
Credits
4
Internal Marks
30
External marks
70
Total
100
Cell, Tissue and Organs: Cell membrane and organelles, Membrane potential, Nernest equation,
GHK equation, Action Potential, Generation and Conduction, Blood Cells, Hematocrit, ESR and its
significance, blood coagulation, immunity and antibodies, Blood Groups and blood transfusion,
different type of tissues and organs.
Introduction to human body, Anatomical position: terminology, regions and planes, Homeostasis.
Muscular and Nervous System: Type of muscles, properties of muscles (excitability and
contractility, all or none law, refractory period, fatigue and elasticity), Structure and function of
neurons, Electrical potentials (Generator & receptor), Nerve conduction, motor unit, Neuromuscular
junction, receptors and reflex arc, Brain, spinal cord, physiology of vision, Physiology of middle and
internal ear, Endocrine glands.
Cardiac and Respiratory System: Structure and function of heart, blood vessels, Heart valves and
sounds, Cardiac cycle, Cardiac output, Coronary, systematic and pulmonary circulation, Blood
Pressure and feedback control, Respiratory pathways (upper and lower), Mechanism of respiration,
respiratory membrane and gaseous exchange, feedback control mechanism of respiration.
Digestive, Excretory and Skeletal System: Organization of GI System, Digestion and absorption,
Liver, Pancreas, Structure of Nephron, Mechanism of Urine formation, Urine Reflex, Integumentary
system, Temperature regulation. Skeletal System & Joints: Types of bones, classification, Structure
and composition of bone, cartilage, tendon, ligament, Classification of joints, structure of synovial
joint, major joints of the body.
Books Recommended:
1.
2.
3.
Ross and Wilson,”Anatomy and Physiology in Health and Illness”, ELBS pub, 2010.
Guyton and Hall,”Textbook of Medical Physiology, 12th ed.”, Saunders, 2011.
Tortora and Grabowski,”Principles of Anatomy and Physiology”, Wiley, 2011.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
5
BME – 712 : Biomedical Sensors and Transducers
M. Tech. (Semester – 1)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Transducers Principles: Classification, static and dynamic characteristic of transducers,
Temperature transducers: RTD, Thermistor, Thermocouple, Displacement transducers: Potentiometer,
resistive strain gauges, capacitive transducer, Pressure transducer: LVDT, semiconductor transducers,
catheter tip transducers, Piezoelectric transducer, Photoelectric transducers, Flow transducers:
magnetic, resistive and ultrasonic
Biochemical Transducers: Electrode theory, electrode impedance, metal-electrolyte interface and
electrode-tissue interface, Bio-potential electrodes: microelectrodes, body surface electrodes, needle
electrodes, electrodes for ECG, EEG, and EMG. Electrodes: hydrogen electrodes, Ag/AgCl
electrodes, Calomel electrodes, specific ion electrodes, pH electrode, O2 and CO2 electrode.
Optical Sensor and Radiation Detectors: Principles of optical sensors and types of optical sensors,
Optical fibers, LASERs, Radiation detectors: Proportional counter, Gas-ionization chamber, Geiger
counters, Scintillation detectors.
Biological Sensors: Receptors in the human body, Ion exchange membrane electrodes, enzymatic
biosensors, Basic principles of MOSFET biosensors & BIOMEMS, basic idea about Smart sensors.
Biomedical Measurements: Body temperature measurement, endoscopes and biopsy, Catheters,
blood flow measurement, biomedical sensor for ionizing radiations, medial ultrasonic transducers,
infrared radiation measurement, flow sensor for respiration measurements, sensors for blood pH and
gases.
Books Recommended:
1.
S.C. Cobbold, “Transducers for Biomedical Instruments”, Wiley, 1974.
2.
3.
4.
John G. Webster, “Medical Instrumentation Application and Design” 4th Ed, Wiley, 2011.
Deric P. Jones, ”Biomedical Sensors”, Momentum press, 1St Ed, 2010.
Gabor Harsanyi, “Sensors in Biomedical Applications: Fundamental Technologies and
Applications” CRC Press, 1St Ed, 2000.
Shakti Chatterjee & Aubert Miller, “Biomedical Instrumentation Systems”, Delmer Cengage
Learning, 1St Ed, 2010.
5.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
6
BME – 713 : Biomedical Signal Conditioning
M. Tech. (Semester – 1)
L
4
T
0
P
0
Credits
4
Internal Marks
30
External marks
70
Total
100
Biomedical Signals and Artifacts: Nature of signal and noise, frequency domain analysis of signals,
types of noise, interfering and modifying signals, Review of the electrical characteristics of a variety
of physiological and biomechanical signal sources and sensors: EMG, ECG, EEG, blood pressure,
limb movement: inclination, strain, joint angle, acceleration, Acquisition of biomedical signals,
examples of biomedical noisy signals.
Amplifiers: Bioelectric amplifiers: Inverting and non-inverting amplifier, OP-Amp parameters, OpAmp transfer characteristics, equivalent circuit of Op-Amp, differential input – differential output
amplifier, general-purpose linear and non-linear electronic circuits typically found in industrial
applications, specification sheets for op amps, Instrumentation amplifiers and transfer characteristics,
Transducer bridge Amplifier.
Filters and circuits: Introduction, Frequency and time domain analysis of low pass, high pass, band
pass, and band stop filters. Filter class- Butterworth, Chebyshev, Bessel, Elliptic. Design of active
high-pass, low pass, band-stop, and all-pass filters. Frequency discriminators, oscillators, linear
voltage regulator, wheat stone bridge circuits, IC 555 Timer and circuits: Astable multivibrator,
Monostable multivibrator
Applications of Signal conditioning: Special features of Bioelectric amplifiers, Amplifier selection
for a variety of biomedical sensors, Wheatstone bridge design, Active filter design using standard
approaches, Front-end analogue circuit design for EMG, ECG, EEG ,Front-end analogue circuit
design for limb movement sensing, Power supply topologies for biomedical instruments
Books Recommended:
1.
2.
3.
R. B. Northrop, “Analysis and Application of Analog Electronic Circuits to Biomedical
Instrumentation”, 2nd ed., CRC Press, 2012.
J. D. Bronzino, “Biomedical Engineering Handbook”, 3rd ed.,CRC Press & IEEE Press, 2006.
Ramón Pallás-Areny, John G. Webster,”Sensors and Signal Conditioning”, 2nd ed., Wiley
publishers, 2000.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
7
BME – 714 : Biomedical Equipments
M. Tech. (Semester – 1)
L
4
T
0
P
0
Credits
4
Internal Marks
30
External marks
70
Total
100
Bioelectric Signals and Electrodes: Bio-potentials and their origin: ECG, EEG, EMG, ENG, ERG,
EOG, MEG. Bio-potential electrodes, generalized medical instrumentation system-Man machine
interface.
Diagnostic Equipments: ECG: normal and abnormal waveform, diagnosis interpretation, ECG leads
connections, Einthoven triangle, Plethysmography, Blood pressure measurement: direct and indirect
methods, Cardiac output measurements, Phonocardiography. Respiratory volume measurement,
Impedance pneumograph, Spirometers, Pneumotachometers. EEG: signal amplitudes and frequency
bands, EEG machine. Audiometers, Auto analyzer, Blood cell counter, Pulse oximeters, Endoscopes,
Laparoscopes and Camera pill.
Therapeutic Equipments: Heart lung machine, Dialyzers: basic principle of dialysis, different types
of dialyzer, membranes, portable type. Cardiac pacemakers: external and Implantable pacemaker.
Cardiac defibrillator: DC defibrillator, implantable defibrillator and defibrillator analyzer. Ventilators,
Anesthesia machine, Short wave diathermy, microwave diathermy, ultrasonic therapy unit,
electrotherapy
Patient Safety: Electric shock hazards, leakage currents, electrical safety analyzer, testing of
biomedical equipments. Calibration and testing of biomedical equipments.
Modern biomedical equipments and systems: Market scenario.
Books Recommended:
1.
2.
3.
4.
John G. Webster, “Medical Instrumentation Application and Design” 4th Ed, Wiley, 2011.
Joseph J Carr, John M Brown, “Introduction to Biomedical Equipment Technology”, Pearson
Education, NewDelhi, 2011.
L. J. Street, “Introduction to Biomedical Engineering Technology”, 2 nd Ed, CRC Press, 2011
Khandpur R S, “Medical Instrumentation: Application and Design”, 3Rd Ed, John Wiley &
Sons, 2009.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
8
BME – 715 : Biomaterials & Artificial Organs
M. Tech. (Semester – 1)
L
3
T
2
P
0
Credits
4
Internal Marks
30
Part – A
External marks
70
Total
100
BIOMATERIALS
Structure of Biomaterials and Bio-Compatibility: Historical developments, definition and
classification of biomaterials, impact of biomaterials, mechanical properties, wound healing process,
tissue response to implants, safety and efficiency testing, bio-compatibility.
Metallic and Ceramic Biomaterials: Stainless steel, cobalt chromium alloys, titanium based alloys,
nitinol, metallic corrosion, medical applications, biological tolerance of implant metals. Relatively
bioinert bioceramics, biodegradable ceramics, surface reactive or bioactive ceramics, composites,
analysis of ceramic surfaces, deterioration of ceramics, medical applications, Nano-composites.
Synthetic and Biopolymers: Polymers in biomedical use, biodegradable synthetic polymers, silicone
rubber, plasma polymerization, microorganism in polymeric implants, bio polymers, polymer
sterilization.
PART – B
ARTIFICIAL ORGANS
Introduction: Overview of organ replacement, design consideration, evaluation process.
Artificial Heart, Lung & Liver: Artificial heart: engineering design & concerns, circulatory assist
devices, cardiac valve prostheses. Cardiopulmonary bypass (heart-lung machine) - principle, block
diagram and working, artificial lung versus natural lung, lung replacement devices, tracheal
replacement devices, laryngeal replacement devices, artificial oesophagus, liver functions: hepatic
failure, liver support systems, general replacement of liver functions.
Artificial Blood, Pancreas and Skin: Artificial oxygen carriers, fluorocarbons, haemoglobin for
oxygen carrying plasma expanders, haemoglobin based artificial blood. Structure and functions of
pancreas, diabetes, insulin therapy, insulin administration systems. Vital functions of skin, current
treatment of massive skin loss, design principles for skin replacement, Cosmetic surgery.
Books Recommended:
1.
2.
3.
4.
Sujata V Bhat, “Biomaterials”, 2nd ed, Narosa Publishing House, New Delhi, 2010.
J. B. Park, J. D. Bronzino, “Biomaterials - Principles and Applications”, CRC press, 2002.
Larry L Hench, Julian R Jones,” Biomaterials, Artificial Organs and Tissue Engineering”,
Woodhead Publications, Cambridge, 2005.
Joon Park and R. S. Lakes, “Biomaterials: An Introduction”, 3rd ed, Springer, 2007.
Note: Examiner will set eight questions in total divided in Parts A and B. Each part should have four
questions. Students have to attempt five question covering at least two questions from each part.
9
BME – 716 : Biomedical Sensors and Transducers Lab
M. Tech. (Semester – 1)
L
--
T
--
P
4
Credits
2
Internal Marks
30
External marks
70
Total
100
LIST OF EXPERIMENTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Note:
Wheatstone Bridge Circuit and Measurement of Resistance using electronics kit.
Strain Gauge Application and Measurement of Unknown Load.
Linear Variable Differential Transformer Measurements.
Measurement of pressure using piezoelectric pick up.
Study of temperature transducers- thermistors, RTD, Thermocouple.
Study of pH electrode and measurement of blood pH.
Measurement of blood flow using electromagnetic flow transducer.
Study of ultrasonic transducers and their application.
Study of optical transducers and their application.
Study and design of electronic stethoscope.
At least seven experiments are to be performed by the students from the above topics. The
course coordinator may also design and set experiments in addition to above topics as per the
scope and requirement of the syllabus.
10
BME – 717 : Biomedical Equipments Lab
M. Tech. (Semester – 1)
L
--
T
--
P
4
Credits
2
Internal Marks
30
External marks
70
Total
100
LIST OF EXPERIMENTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Measurement of Blood Pressure & analysis.
Measurement of respiration rate & analysis.
ECG, EEG recording and analysis.
EMG recording and analysis.
Study of phonocardiography.
Study of surgical diathermy.
Study of pacemaker & simulator.
Study of defibrillator & simulator.
Measurements using patient monitoring systems(BIOPAC).
Calibration and troubleshooting of the biomedical instruments.
Note: At least seven experiments are to be performed by the students from the above topics. The
course coordinator may also design and set experiments in addition to above topics as per the scope
and requirement of the syllabus.
11
M.Tech. (Biomedical Engineering)
Semester -2
12
BME – 721 : Biomedical Image Processing
M. Tech. (Semester – 2)
L
4
T
0
P
0
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction: Overview of medical imaging technology, systems, and modalities. Medical Image
Formation Principles, Medical Image Storage, Archiving and Communication Systems and Formats:
PACS, DICOM, TIFF, RIS and HIS.
Medical Image Processing: Algorithms, Thresholding, Contrast Enhancement, SNR, Characteristics,
Filtering, Histogram Modeling, Medical Image Visualization, Image Compression Models - Variable
length coding, Huffman coding, Lossless predictive coding, Lossy predictive coding
Medical Image Segmentation: Histogram-based methods, Region growing and watersheds, Markov
Random Field models, active contours, model-based segmentation. Multi-scale segmentation, semiautomated methods, clustering-based methods, classification-based methods, atlas-guided approaches,
multi-model segmentation. Medical Image Registration
Applications of Medical Imaging: Validation, Image Guided Surgery, Image Guided Therapy,
Computer Aided Diagnosis/Diagnostic Support Systems
Books Recommended:
1. Rafel C Gonzalez, Richard E Woods, “Digital Image Processing”, 2nd ed, Addison - Wesley
Publishing Company, New Delhi, 2002.
2. William R Hendee, E. Russell Ritenour, “Medical Imaging Physics”, 4th ed., John Wiley & Sons, Inc.,
New York, 2002.
3. Paul Suetens, “Fundamentals of Medical Imaging”, 2nd ed., Cambridge University press, 2009.
4. J. Michael Fitzpatrick and Milan Sonka, “Handbook of Medical Imaging, Vol. 2, SPIE Press, 2000
5. Anil K Jain, “Fundamentals of Digital Image Processing”, Prentice Hall of India Pvt. Ltd., New
Delhi, 1988.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
13
BME – 722 : Biomedical Signal Processing
M. Tech. (Semester – 2)
L
4
T
0
P
0
Credits
4
Internal Marks
30
External marks
70
Total
100
Signals and Information: Definitions and properties of Laplace transform, continuous-time Fourier
series and transform, DFT, FFT, z-transform, Sampling theorem, Linear Time-Invariant (LTI)
Systems: definitions and properties; causality, stability, impulse response, convolution, poles and
zeros, parallel and cascade structure, frequency response, group delay, phase delay. Applications of
Digital Signal Processing.
Filters: LTI Digital Filters, Recursive and Non-Recursive Filters, Convolution and Correlation, Filter
Structures- Direct, Cascade and Parallel Forms, Design of digital FIR and IIR filters, Study and
application of Matlab signal processing toolbox.
Advanced Signal Processing: Wavelet Transforms – Continuous and discrete wavelet transform,
filter banks, Adaptive signal processing- adaptive noise cancellation, phase sensitive detection.
Bio-signals: Acquisition of physiological signal, characteristics, frequency domain representation;
stationary and non-stationary bio-signals, Waveform detection and Pattern Recognition, Computation
of diagnostic signal parameters.
Books Recommended:
1.
2.
3.
4.
5.
D. C. Reddy,”Biomedical Signal Processing Principles and Techniques”, Tata McGraw-Hill,
2005.
R. M. Rangayyan,”Biomedical Signal Analysis A Case Study Approach” John Wiley, 2002.
Willis J. Tompkins,”Biomedical Digital Signal Processing”, Prentice Hall of India
Publications, 1995.
Proakis, “Digital Signal Processing”, PHI Publications, 2007.
John L. Semmlow, “Bio-signal and Biomedical Image Processing”, Marcel Deccar
Publications, 2004.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
14
BME – 723 : Biomechanics
M. Tech. (Semester – 2)
L
3
T
2
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Mechanics: Review of the principles of mechanics, Vector mechanics-resultant
forces of coplanar & non-coplanar, concurrent & non-concurrent forces, parallel force in space,
equilibrium of coplanar forces, Newton’s laws of motion, work and energy, moment of inertia.
Biofluid & Tissue Mechanics: Stress – strain, elasticity, Hooke’s law – viscosity, Newtonian fluid
and non-Newtonian fluid, viscoelastic fluids, vascular tree, relationship among diameter, velocity and
pressure of blood flow.
Bone: Mechanical properties, viscoelastic properties, Maxwell & Vought models - anisotropy,
electrical properties of bone, fracture mechanisms, pseudo elasticity - nonlinear stress strain
relationship
Biomechanics of Joints: Skeletal joints, forces and stresses in human joints, analysis of rigid bodies
in equilibrium, free body diagrams, biomechanical analysis of elbow, shoulder, spinal column, hip
knee and ankle.
Locomotion: Human locomotion - gait analysis, goniometry, ergonomics, foot pressure
measurements – pedobarograph, force platform - mechanics of foot, total hip prosthesis: requirements,
different types of components, stress analysis, instrumentation - knee prosthesis.
Books Recommended:
1.
2.
3.
4.
Nihat Ozkaya, Margareta Nordin, David Goldsheyder, Dawn Leger, “Fundamentals of
Biomechanics: Equilibrium, Motion, and Deformation”, 3rd ed., Springer, New York, 2012.
Susan J Hall, “Basic Biomechanics”, Tata McGraw Hill, New York, 2004.
Y C Fung, “Biomechanics: Mechanical Properties of Living Tissues”, Springer, 2nd ed., 1993
D. J. Schneck, J. D. Bronzino, “Biomechanics-Principles and Applications”, CRC Press, 2003
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
15
BME – 724 : Diagnostic Imaging and Radiation Biology
M. Tech. (Semester – 2)
L
3
T
2
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Imaging with Ionizing Radiation: Digital X-Rays: Principles and production of soft and hard xrays, Scattered radiation, Angiography, Fluoroscopy, Image intensifier, Multi section radiography,
Radiation detectors, X-ray Computerized Tomography (X-ray CT) - imaging modes and types, Single
Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET).
Magnetic Resonance Imaging (MRI): Physics of nuclear magnetic resonance, T1 and T2 relaxation
time, spin-echo sequences, electronics and instrumentation of MRI, mathematics and algorithms,
methods and techniques of MRI, Functional MRI (f-MRI), clinical applications, fluid flow imaging,
chemical-shift and spectroscopic imaging.
Ultrasound and other Techniques: Propagation of ultrasound waves in fluids, solids and tissue.
Doppler effect, Ultrasonic transducers and instrumentation, modes of ultrasonic imaging, thermal
imaging techniques, fluoroscopy, endoscopy-surgery navigation.
Radiation Biology: Interaction of radiation with matter, Application of Radioisotopes: Alpha, Beta
and Gamma emission, Principle of radiation detectors, dot scanners, Nuclear angiogram, Principles of
Radiation therapy. Introduction to Radiation safety, Hazardous effect of Radiation, Radiation
Protection Techniques, Safety limits, Radiation monitoring.
Books Recommended:
1. Steve Webb, “The Physics of Medical Imaging”, Taylor & Francis, New York, 2010.
2. William R Hendee, Russell Ritenour E, “Medical Imaging Physics” John Wiley, New York, 2002.
3. Khandpur R S, “Handbook of Biomedical Instrumentation”, Tata McGraw Hill, New Delhi, 2011.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
16
BME – 725 : Biomedical Signal and Image Processing Lab
M. Tech. (Semester – 2)
L
--
T
--
P
4
Credits
2
Internal Marks
30
External marks
70
Total
100
LIST OF EXPERIMENTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Note:
Signal acquisition and analysis- Temporal averaging and template matching.
Noise removal in ECG signal using Chebychev filter.
Noise removal in ECG signal using Butterworth filter
Designing an FIR filter using window techniques in MATLAB.
Design of Notch filter for elimination of 50Hz from ECG signal.
Data Compression Techniques
Arithmetic and logical operations on images.
Image compression, segmentation and enhancement using MATLAB.
Algebric Reconstruction Techniques (A.R.T.)
Real time Bio-signal /image acquisition and processing.
At least seven experiments are to be performed by the students from the above topics. The
course coordinator may also design and set experiments in addition to above topics as per the
scope and requirement of the syllabus.
17
BME – 726 : Biomedical Signal Conditioning Lab
M. Tech. (Semester – 2)
L
--
T
--
P
4
Credits
2
Internal Marks
30
External marks
70
Total
100
LIST OF EXPERIMENTS
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
Note:
Study of linear applications of op-amp.
Study and design of active filters using op-amp
To study A/D and D/A converter using op-amps.
Characteristics of bio-potential amplifier for ECG& EMG signals
Isolation of bio-signal (EMG / ECG)
ECG processing and analysis.
EEG processing and analysis.
Detection of QRS component from ECG signals.
Study of nonlinear application of op-amp.
Noise removal from ECG/EMG/EEG signals.
At least seven experiments are to be performed by the students from the above topics. The
course coordinator may also design and set experiments in addition to above topics as per the
scope and requirement of the syllabus.
18
Elective-I
Semester -2
19
BME – 761 : Bioethics, IPR and Standards
M. Tech. (Semester – 2)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Biomedical Ethics: Principles, rules and moral decisions of biomedical ethics, respect for autonomy,
voluntariness information and informed consent, competency, non-maleficence, the rule of the double
effect, befecience, paternalism, justice.
Ethical Issues in Design and Manufacture of Medical Devices: - Cost benefit analysis, professional
restrictions and responsibility, rights of engineers, conflict of interest, codes of ethics for biomedical
engineers, ethics of implant use and marketing.
Basic Principles of IPR Laws: History of IPR-GATT,WTO,WIPO & TRIPs, Role of IPR in
Research & Development, Concept of property, Different forms of IPR – copyright, trade mark,
Industrial Designs, Layout designs of Integrated circuits, Patents, Geographical Indications,
Traditional Knowledge, Plant varieties, Trade secrets
Safety and Standards: Regulatory Authorities for medical device regulation in India (CDSCO),
Global Harmonization Task Force for device regulation abroad, Quality management system for
medical devices (ISO 9001 and ISO13485), safety and standardization for risk management (ISO
14971), European standard conformity (CE marking), FDA guidelines for medical devices approval
and classification based on risk assessment.
Books Recommended:
1.
2.
3.
4.
5.
Daniel A Vallero,”Biomedical ethics for Engineers”, Academic Press, New York, 2007.
Ronald Munson, “Intervention and Reflection: Basic Issues in Medical Ethics”, Wadsworth
Pub. Co., 1992.
Prabuddgha Ganguli, “Intellectual Property Rights”, TMH Publishing Co. Ltd., 2001.
Patents by N.R. Subbaram, Pharma Book Syndicate, Hyderabad, India, 2006.
World Intellectual Property Organizations (WIPO) Handbook/ Notes, WIPO Copyright
treaty, 1996.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
20
BME – 762 : Rehabilitation Engineering
M. Tech. (Semester – 2)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Rehabilitation Engineering: Engineering concepts in sensory rehabilitation, motor
rehabilitation, communication disorders, fundamental principles (structure, function, performance and
behavior), measurement objectives and approaches (characterizing human system and its subsystems,
characterizing tasks, characterizing systems in high-level-task situations), decision making processes,
quality of measurements, quality assurance.
Orthopedic Prosthetics and Orthotics in Rehabilitation: Prosthetic knee, prosthetic hand, orthotic
knee joint, FES systems (restoration of hand functions, restoration of standing and walking), hybrid
assistive systems, active prostheses (active above-knee prosthesis, myoelectric hand and arm
prosthesis)
Wheeled Mobility: Wheelchairs and Personalized Transportation: Introduction, wheelchair
structure and component design (materials, frame design), ergonomics of wheelchair propulsion
(kinematics, kinetics, net joint forces and moments), power wheelchair electrical systems (integrated
controls, power system, electromagnetic compatibility), personal transportation (lift mechanisms,
wheelchair restraint mechanisms, hand controls)
Sensory Augmentation and Alternative Communication: Introduction, visual system, visual
augmentation (tactual vision substitution, auditory visual substitution), auditory system (visual
auditory substitution, tactual auditory substitution), tactual system (tactual augmentation and tactual
substitution), language representation methods and acceleration techniques, user interface, outputs,
outcomes, intervention and training.
Books Recommended:
1.
2.
3.
4.
5.
6.
J. D. Bronzino, “Biomedical Engineering Handbook”, 3rd ed.,CRC Press, 2006.
R. A Cooper, H. Ohnabe, and D. A. Hobson, “An Introduction to Rehabilitation Engineering”,
Taylor & Francis, 2007.
R.V. Smith and J. H. Leslie, “Rehabilitation Engineering”, CRC Press, USA, 1990.
Fuher, “Rehabilitation Outcomes: Analysis and Measurement”, Brookes, 1987.
S. L. Michlovitz, “Modalities for Therapeutic Intervention”, 4th ed., F A Davis Co., 2005.
S. Kumar, Perspectives in Rehabilitation Ergonomics, Taylor and Francis, CRC Press, 2009.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
21
BME – 763 : Fiber Optics and Laser for Medical Applications
M. Tech. (Semester – 2)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Basics of LASER: Principle and operation of LASER, LASER materials, major types of LASER,
medical LASER, basic component of LASER equipments, different types of LASER( He-Ne LASER,
CO2 LASER, Nd-Yag LASER, Krypton LASER), The application of LASER in medicine, LASER
Safety.
LASER Effects on Biological Tissue: LASER tissue interactions, thermal responses of tissues, effect
of UV for Photo-biological Studies, spectroscopic diagnostics of malignant tumors and plaque,
clinical applications of Low-Power LASER- Photodynamic therapy, plaque removal, lithotripsy etc.
Optical Fiber: Fundamentals, propagation of light in optical fibers (NA, TIR, angle of acceptance),
attenuation , bending losses, scattering , absorption, dispersion, power transmission through optical
fibers, power budgeting in optical, medical application of optical fibers.
Endoscopy: Introduction and fundamentals, different types of endoscope; flexible and rigid
endoscopy, construction and operation, endoscopic ultrasound imaging-principles, endoscopy for
diagnosis and therapy.
Books Recommended:
1.
2.
3.
4.
R. W. Waynant, LASER in Medicine,1st ed., CRC Press, 2001.
Abraham Katzir, LASER and optical fibres in medicine, Academic press, 1998.
M Niemz, “LASER-tissue interactions”, Springer, New York, USA, 1996.
JA Buck, “Fundamentals of optical fibers”, Wiley and Sons, New York, USA, 1995.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
22
BME – 764 : Design Principles for Medical Systems
M. Tech. (Semester – 2)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Biomedical Engineering Design: Essentials of Design, Idea generation, Design
management, Product definition, Product documentation, Product development, structured and
unstructured design techniques.
Product design and material selection: Computer aided design process, rapid prototyping, industrial
design, Biocompatibility, international regulatory efforts, biological control tests, Safety analysis in
design.
Product testing and Quality Control: Prototyping and testing, premarket testing and validation,
drug development and clinical trials, system testing, regulation and standards, manufacturing and
quality control
Design Case Studies: Multi-detector brain scanning system, testing of anesthetists, apnea detection
system, cancer clinic charting, EKG analysis techniques, choosing the correct plastic material.
Books Recommended:
1.
2.
3.
4.
P. H. King, R. C. Fries, “Design of biomedical devices and systems”, CRC Press, 2003.
Richard C. Fries, “Reliable Design of Medical Devices”, CRC Press, 2013.
Carl T. DeMarco, “Medical Device Design and Regulation”, ASQ Quality Press, 2011.
Richard C. Fries, “Handbook of Medical Device Design”, CRC Press, 2000.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
23
BME – 765 : Drug Delivery Systems and Implantable Devices
M. Tech. (Semester – 2)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Fundamental Concepts of Drug Release: Drug release, controlled drug release, sustained release
time, drug delivery systems. Pre requisites of drug candidates, various approaches and
classification, dose calculation for controlled release. Brief introduction to polymers parameters
affecting selection of polymers for modified release systems.
Novel Drug Delivery Systems(DDS): Diffusion Controlled DDS (Reservoir and Monolithic
Systems), Water Penetration Controlled DDS (Osmotic and Swelling Controlled System), Chemically
Controlled DDS (Biodegradable Reservoir and Monolithic Systems, Responsive Smart Systems
(Physically and Chemically Responsive Systems, Mechanical, Magnetic or Ultrasound Responsive
Systems, Biochemically Responsive and Self-Regulated Systems), Particulate DDS (Microparticulates, The Enhanced Permeability and Retention Effect, Polymer-Drug conjugates, PolymericMicelle Systems, Liposome Systems)
Microencapsulation: Introduction, concept of microencapsulation, merits, demerits and application,
Types of microencapsulation: chemical encapsulation processes, complex, polymer-polymer
incompatibility, interfacial polymerization, and in-situ polymerization, mechanical encapsulation
process.
Implantable Devices: Implantable Cardiovascular Assist Devices, Artificial RBC Substitutes,
Orthopedic Applications, Dental Implants, Adhesives and Sealants, Ophthalmological Applications
(Various types of contact lenses, Intra Ocular Lens Implant), Cochlear Prostheses.
Books Recommended:
1.
2.
3.
4.
Ratner-Hoffman, “Biomaterial Science: An Introduction to Materials in Medicine”, Elsevier
Academic Press, 2004.
J.D. Bronzino, “The Biomedical Engineering Handbook”, CRC Press, 2000.
N.K. Jain, “Advances in Controlled and Novel Drug Delivery”, CBS Publication, 2001.
Peter J. Tarcha, “Polymers for Controlled Drug Delivery”, CRC Press, 1991.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
24
M.Tech. (Biomedical Engineering)
Semester -3
25
Elective Subjects-II & III
26
BME – 771 : Telemedicine
M. Tech.(Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Telemedicine: History of telemetry and telemedicine, definition of telemedicine,
Tele-health, Tele-care, benefits & limitations of telemedicine. Type of Information: Audio, video, still
images, text, data and fax. Type of communications and network: Network architecture, PSTN,
POTS, ANT, ISDN, internet, air/ wireless communications.
Ethical and Legal Aspects of Telemedicine: Confidentiality, patient rights and consent:
confidentiality and the law, the patient-doctor relationship, access to medical records, consent
treatment - data protection & security, jurisdictional issues. Data security and Privacy.
Picture Archiving and Communication System: Introduction to radiology information system,
ACS, PACS strategic plan, needs assessment, technical issues, PACS architecture.
Applications of Telemedicine: Tele-radiology, Tele-pathology, Tele-cardiology, Tele-cytology,
Tele-oncology, Tele-dermatology, Tele-surgery, Telephonic medicine.
Books Recommended:
1.
2.
3.
Norris A C, “Essentials of Telemedicine and Telecare”, John Wiley, 2001.
Olga Ferrer-Roca & Marcelo Sosa, “Handbook of Telemedicine” IOS Press, 2002.
H K Huang, “PACS and Imaging Informatics: Basic Principles and Applications” WileyBlackwell, 2010.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
27
BME – 772 : Embedded Systems in Medicine
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Embedded System: Introduction, design challenge, processor technology, IC
technology, Design technology, Trade-offs, Single purpose processors, RT-level combinational logic,
sequential logic (RT-level), custom single purpose processor design (RT-level) and optimization
techniques.
General Purpose Processors, State Machine and Concurrent Process Models: Basic architecture,
operation, Pipelining, Programmer’s view, development environment, Application Specific
Instruction-Set Processors (ASIPs) – Micro Controllers and Digital Signal Processors, models Vs.
languages, finite state machines with data path model (FSMD), using state machines, program state
machine model (PSM), concurrent process model, concurrent processes, communication among
processes, synchronization among processes, implementation, data flow model, real-time systems
Communication Interfaces: Need for communication interfaces, RS232 / UART, RS422 / RS485,
USB, Infrared, IEEE 1394 Firmwire, Ethernet, IEEE 802.11, Blue tooth.
Basic Concepts of Real Time Operating System: Architecture of the Kernel, Tasks and Task
scheduler, Interrupt service routines, Semaphores, Mailboxes , Message Queues, Event Registers,
Pipes, Signals, Timers, Memory Management, Priority inversion problem, Embedded operating
systems Embedded Linux, Real-time operating systems, RT Linux, Handheld operating systems
Books Recommended:
1.
2.
3.
4.
Frank Vahid, Tony D. Givargis, “Embedded System Design – A Unified Hardware/Software
Introduction”, John Wiley, 2002.
K.V.K.K. Prasad, “Embedded / Real Time Systems”, Dreamtech Press, 2005.
Sri Ram V Iyer - Pankaj Gupta, “Embedded Real Time Systems Programming”, Tata McGraw
Hill, 2005.
Steve Heath, “Embedded System Design”, Elsevier, Second Ed., 2004.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
28
BME – 773 : MEMS and Medical Applications
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Microsystems: Historical background, Smart materials and structures, Microsystems
and their advantages, Materials used: substrates and wafers - silicon and silicon compounds in MEMS
- packaging materials, Current scenario of MEMS for health care.
Microsystem Fabrication & Packaging: Photolithography, Chemical Vapor Deposition, Physical
vapor deposition, Etching, Bulk and Surface Micromachining. Microsystem packaging and essential
packaging technologies.
Working Principles of Microsystems: General principles of pressure sensors: micro-actuators,
electrostatic forces, piezoelectric crystals, intelligent materials & structures. General principle of
biomedical sensors, optical sensors and thermal sensors.
Microsystems Application in Medicine (BioMEMS): Special features/requirements for medical
applications, Drug delivery systems and MEMS, Application models - Blood pressure sensors,
Biochips, Micro needles, Microelectrodes, Neural prosthesis, Catheter end sensors.
Books Recommended:
1.
2.
3.
4.
Tai-Ran Hsu, “MEMS and Microsystems: Design and Manufacture”, Tata McGraw Hill, 2003.
Steven S Saliterman, “Fundamentals of BioMEMS and Medical Microdevices”, SPIE, 2006.
Mohamed Gad-el-Hale, “MEMS Applications”, CRC Press, 2006.
Gerald A. Urban, “BioMEMS”, Springer, 2010.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
29
BME – 774 : Physiological Control Systems
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Physiological Control System: Fundamental concepts, physiological control system
analysis, difference between engineering and physiological control system, mathematical modelling
Time and Frequency Domain Analysis of Linear Control System: linearized respiratory
mechanics (open loop versus close loop), transient response of first and second order systems, steadystate response to sinusoidal inputs. Graphical representation of frequency response (Bode plot and
Nyquist plot), frequency response of circulatory control system.
Stability Analysis: Stability and transient response, root locus plots, Routh-Hurwitz and Nyquist
criteria for stability, stability analysis of pupillary light reflex by Routh-Hurwitz analysis and Nyquist
analysis.
Optimization in Physiological Control Systems: Optimization in systems with negative feedback,
control of respiratory frequency, airflow pattern regulation, control of aortic flow pulse, adaptive
control of physiological variables, nonlinear analysis of physiological control systems.
Books Recommended:
1.
2.
3.
Michael C.K.Khoo, “Physiological control systems” Prentice Hall of India, 2001.
B.C. Kuo, “Automatic Control System” Prentice Hall of India 2004.
D.O. Cooney, “Biological Engineering Principles” Marcel Dekker, Inc. 2002.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
30
BME – 775 : Biomedical Waste Management
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction: Definition of general and hazardous health care waste, Infectious waste, geno-toxic
waste, waste sharps, categorization and composition of Biomedical waste, major and minor sources of
biomedical waste, Segregation of waste, Color coding, waste handling and disposal
Hazard of Biomedical Waste: Need for disposal of biomedical waste, Specifically Communicable
diseases, Diseases epidemiology and mode of transmission of disease, Environmental pollution by
biomedical waste - causes, consequences, mitigation and remedies.
Treatment Technologies for Wastes: Mechanical Treatment & Chemical Disinfections,
Conventional
Treatment Technologies : Wet thermal technology, Incineration, Microwave
Technology, Autoclave system, Hydro clave system, Electro Thermal Reactivation(ETP), Treatment
Process Electron beam Technology, Plasma Pyrolysis/Gasificaton systems
Laws of Biomedical Waste Handling: Legislation, policies and law regarding environment on
Health care waste management, Biomedical waste management and handling rules 1998 and its
amendment. CPCB guidelines. World Health Organization guidelines on Management of wastes
from Hospital wastes
Books Recommended:
1.
2.
3.
Anantpreet Singh, Sukhjit Kaur, “Biomedical Waste Disposal”, 1st ed., Jaypee Publishers (P)
Ltd, India, 2012.
Sushma Sahai, “Bio-Medical Waste Management”, APH Publishing Corporation, India, 2009.
Sanskriti Sharma, “ Hospital Waste Management and Its Monitoring”, Jaypee Publishers (P)
Ltd, India, 2002.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
31
BME – 776 : Artificial Intelligence and Expert Systems
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Artificial Intelligence: History and applications, Components of AI Structures and
Strategies for state space search- Data driven and goal driven search , Depth First and Breadth First
Search, DFS with Iterative Deepening ,Heuristic Search- Best First Search, A* Algorithm, Constraint
Satisfaction, Knowledge representation - Propositional calculus
Introduction to Fuzzy Logic: Introduction to fuzzy sets, Membership functions (γ function, sfunction, L-function, Triangular Membership function, Gaussian Membership function), Operations
on Fuzzy Sets (Fuzzy T Norm, Fuzzy S Norm, Fuzzy Complement), Extension of Fuzzy Sets, Fuzzy
Relations, Projection of Fuzzy Relations, Cylindrical Extension of Fuzzy Relations, Fuzzy Max-Min
and Max Product Composition.
Introduction to Artificial Neural Networks: Artificial Neural Networks, Principles of Learning in a
Neural Network, Stability and Convergence (Theorems and Examples), McCulloch-Pitts Model,
Perceptron Learning Model and its application in linear classification, Widrow-Hoff’s ADALINE
Model, Multilayer Perceptrons, Back-propagation Learning Algorithm, Application of Artificial
Neural Network as a classifier
Latest Trends and Applications of Artificial Intelligence: Linear Discriminant Analysis, Quadratic
Discriminant Analysis, Independent Component Analysis, Principal Component Analysis,
Performance Analysis of Classifiers, Introduction to Genetic Algorithm based on Schemata Theory,
Convergence Analysis, Application of GA in Optimization Problems and Machine Learning, Particle
Swarm Optimization.
Books Recommended:
1.
2.
3.
4.
5.
Amit Konar, “Artificial Intelligence and Soft Computing: Behavioral and Cognitive Modeling
of Human Brain”, vol.1, CRC Press, 1999.
B Yuan, G.J. Klir, “Fuzzy Sets and Fuzzy Logic: Theory and Applications”,Prentice-Hall, 1995.
Simon Haykin, “Neural Networks: A Comprehensive Foundation”, 2nd ed., Pearson
Education, NJ, USA, 1999.
Li - Fu, “Neural Networks in Computational Intelligence”, McGraw-Hill, 1994.
David E. Goldberg, “Genetic Algorithms in Search, Optimization and Machine Learning”,
Addison Wesley Longman Publishing, New York, USA, 1989.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
32
BME – 777 : Nanotechnology for Biomedical Applications
M. Tech.(Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Nanomaterials Properties: Introduction to Nanotechnology and Nanomaterials, Nanoscale
architecture, effect of nanoscale dimensions on various properties such as structural, thermal,
chemical, mechanical, magnetic, optical and electronic properties.
Nanomaterials Fabrication and Characterization: Top- down processes, lithography, etching bottom-up process, vapor phase deposition methods, molecular beam epitaxy, self-assembly and selforganization. Characterization methods: scanning electron microscopy, transmission electron
microscopy, scanning tunneling microscopy, atomic force microscopy, Raman spectroscopy.
Nanodevices: Magnetic Nanoparticles, Carbon Nanotubes (CNT), Organic field effect transistor,
Organic light emitting diodes. Micro and Nano immunosensors, Bio-Barcode Assay - use of magnets,
gold, DNA and antibodies.
Applications in Medicine: In vivo imaging for the detection of tumors, plaque, genetic defects and
other disease states. Nanorobot medical devices, Artificial scaffolds and Biosynthetic coatings,
Retinal, cochlear and neural implants, PCR, DNA Profiling, Cantilever Sensors, Targeted Drug
Delivery.
Books Recommended:
1.
2.
3.
4.
Pradeep T, “Nano: The essentials, understanding nanoscience and nanotechnology”, Tata
McGraw Hill, New Delhi, 2007.
Chris Binns, “Introduction to nanoscience and nanotechnology,” John Wiley & Sons, New
Jersey, 2010.
Sami Franssila, “Introduction to microfabrication”, John Wiley & Sons, UK, 2010.
Neelina Malsh, “Biomedical Nanotechnology”, Taylor and Francis, CRC Press, UK, 2005.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
33
BME – 778 : Tissue Engineering
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction: Introduction to Tissue engineering, challenges in Tissue Engg, Cellular Therapies,
Grafts, and Extracorporeal Bio-artificial Organs, Human Cells and Grafts as Therapeutic Agents,
Mechanisms Governing Tissues, Clinical Considerations.
Biological & Physical Considerations: Stem Cells, Models for Stem Cell Proliferative Behaviour,
Stem Cell Aging, Tissue Dynamics, Cell Differentiation, Organization of Tissues into Functional
Subunits, Estimating Tissue Function from Spec Sheets, Mass Transfer in 3-D Configurations.
Scaling Up: Fundamental Concept, Key Design Challenges, Time Scales of Mass Transfer, Fluid
Flow and Uniformity, Delivering Cellular Therapies in a Clinical Setting
Future Directions: Functional tissue engineering, Cellular Aspects, Bio-artificial Liver Specifics,
Case study and regulatory issues-cell transplantation for liver, musculoskeletal, cardiovascular,
neural, visceral tissue engineering. Ethics and Regulatory issues
Books Recommended:
1.
2.
3.
John D. Enderle, Susan M. Blanchard, Joseph D. Bronzino, “Introduction to Biomedical
Engineering”, 2nd ed., Elsevier Academic Press, USA, 2005.
Robert P lanza, Robert Langer and Joseph Vacanti, “Principles of tissue engineering”,
Academic Press, California, 2007.
Joseph D. Bronzino, “Tissue Engineering and Organs”, 3rd ed., Taylor and Francis, CRC
Press, Florida, USA, 2006.
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
34
BME – 779 : Sports and Biomedical Engineering
M. Tech. (Semester –3)
L
4
T
0
P
--
Credits
4
Internal Marks
30
External marks
70
Total
100
Introduction to Biomechanics: Fundamentals of Soft Tissue Mechanics (Muscle Architecture, Max
Muscle Stress, Max Muscle Contraction Velocity, Muscle Force-Length Relationship, Muscle ForceVelocity Relationship, Tendon Biomechanics), Mechanics of Head and Neck (Injury Mechanisms,
Mechanical Response, Regional Tolerance), Biomechanics of Chest and Abdominal Impact,
Biomechanical Responses During Impact, Injury Risk Assessment.
Biomechanics of Different Joints of Human Body: Geometry of Articulating Surfaces, Joint
Contact, Axes of Rotation of (Ankle, Knee, Hip, Shoulder, Elbow, Wrist, Hand), Tribology (Friction,
Wear and Surface Damage), Hydrodynamic Lubrication Theories, Boundary Lubrication, Synovial
Joints,
Gait Analysis: Clinical Gait Analysis Information, Data Collection Protocol, Measurement
Approaches and Systems (Stride and Temporal Parameters, Motion Measurement, Ground Reaction
Measurement, Dynamic Electromyography)
Physiology in Sports and Exercise: Muscle Energetic, Cardiovascular Adjustments, Maximum
Oxygen Uptake, Respiratory Responses, Optimization Techniques, Thermal Response, Applications.
Books Recommended:
1.
2.
J. D. Bronzino, “Biomedical Engineering Handbook”, 3rd ed,CRC Press, 2006.
Nordine-Frankel, “Basic Biomechanics of the Musculoskeletal System”, Lea & Febiger, 1989.
3. Arthur T. Johnson, “Biomechanics and Exercise Physiology”, John Wiley and Sons, 1991.
4. Cappozzo-Berne, “Biomechanics of Human Movement: Applications in Rehabilitation, Sports
and Ergonomics”, Bertec Corporation, 1990
Note: Examiner will set eight questions fairly distributed and covering the whole syllabus. Students
have to attempt any five questions in the duration of three hours.
35
BME – 731 : Seminar
M. Tech. (Semester – 3)
L
T
P
Credits
Internal Marks
-
-
4
2
100
External
marks
--
Total
100
Students will select a topic of seminar in emerging areas of Biomedical Engineering and study the
same independently. The topic of the seminar may not be the part of the curriculum. Each student is
required to give a seminar/talk on the same before the committee constituted by Chairman of the
department as per the guidelines decided by the department from time to time.
36
BME – 732 : Dissertation Phase-I
M. Tech. (Semester – 3)
L
-
T
-
P
6
Credits
3
Internal Marks
100
External marks
--
Total
100
The primary objective of this course is to develop in student the capacity for analysis & judgment and
the ability to carry out independent investigation in design/development through a Dissertation work
involving creativity, innovation and ingenuity. The topic of the proposed Dissertation work along with
brief summary shall have to be approved by the Department. The work must start with comprehensive
literature survey and critical appreciation thereof so as to select the research problem.
Around 40% of the Dissertation work should be completed in this semester. The remaining 60% work
will be carried out in the fourth semester. Each student is required to submit a detailed report about
the work done on the topic of Dissertation as per the guidelines decided by the department. The report
shall be evaluated internally through presentations and viva-voce during the semester end as per the
guidelines decided by the department from time to time.
The Dissertation work shall be carried out in GJUS&T, Hisar. If a candidate choses any co-supervisor
from outside the university then prior permission from the Chairman is required on the
recommendation of internal supervisor(s). The external co-supervisor, if any, must be an eminent
person from the reputed institution/organization/industry etc. and also to be approved by the
department.
37
M.Tech. (Biomedical Engineering)
Semester -4
38
BME – 741 : Dissertation Phase-II
M. Tech. (Semester – 4)
L
-
T
-
P
18
Credits
9
External marks
100
Total
100
Around 40% of the Dissertation work should be completed in third semester. The remaining 60%
work will be carried out in the 4th semester. Each student is required to submit a Dissertation on
research work carried out by him/her as per guidelines decided by the department which will be
evaluated by the external examiner. The student is also required to submit progress reports during the
semester and will deliver pre-submission seminar before final submission of Dissertation as per
guidelines decided by the department from time to time. In case of unsatisfactory performance of the
candidate as evaluated Internally/Externally, the candidate have to repeat and improve his
performance. Publication or communication of at least one paper in conference/journal on the
Dissertation work of candidate is must before final submission of Dissertation.
The Dissertation work shall be carried out in GJUS&T, Hisar. However a candidate may carry out
his/her Dissertation work outside the University with prior permission from the Chairman with
recommendation of the internal supervisor(s). The external co-supervisor, if any, must be an eminent
person from the reputed institution/organization/industry etc. and also to be approved by the
department.
39