CNS Drugs
The Role of Antidepressants in the
Management of Fibromyalgia Syndrome
A Systematic Review and Meta-Analysis
Winfried Häuser et al.
Supplemental Digital Content
This Supplemental Digital Content contains the list of studies referred to in the full
version of this article, which can be found at http://adisonline.com/cnsdrugs
© 2012 Adis Data Information BV. All rights reserved.
Supplementary digital content 5: Included and excluded RCTs with SSRIs
Included:
1. Anderberg UM, Marteinsdottir I, von Knorring L. Citalopram in patients with
fibromyalgia--a randomized, double-blind, placebo-controlled study. Eur J Pain.
2000;4:27-35
2. Arnold LM, Hess EV, Hudson JI, Welge JA, Berno SE, Keck PE Jr. A randomized,
placebo-controlled, double-blind, flexible-dose study of fluoxetine in the
treatment of women with fibromyalgia. Am J Med 2002 15;112:191-7
3. Glaxo Study No 29060/433. Treatment of fibromyalgia: a randomized, doubleblind, placebo-controlled study of paroxetine, a selective serotonin re-uptake inhibitor.
Accessed at www.clinicalstudyresults.org/documents/company-study_5748_0.pdf,
accessed August 9,2010
4. Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C. A randomized,
double-blind crossover trial of fluoxetine and amitriptyline in the treatment of
fibromyalgia. Arthritis Rheum 1996;39:1852-9
5. Nørregaard J, Volkmann H, Danneskiold-Samsøe B. A randomized controlled trial
of citalopram in the treatment of fibromyalgia. Pain 1995;61:445-9
6. Patkar AA, Masand PS, Krulewicz S, Mannelli P, Peindl K, Beebe KL, Jiang W. A
randomized, controlled, trial of controlled release paroxetine in fibromyalgia.
Am J Med. 2007;120:448-54
7. Wolfe F, Cathey MA, Hawley DJ. A double-blind placebo controlled trial of
fluoxetine in fibromyalgia. Scand J Rheumatol 1994;23:255-9.
Excluded, reason for exclusion
1. Cantini F, Bellandi F, Niccoli L, Di Munno O. [Fluoxetin combined with
cyclobenzaprine in the treatment of fibromyalgia]. Minerva Med 1994
;85:97-100. Italian. Fluoxetine combined with cyclobenzaprine
2. Chow, K.M., Szeto, C.C., Hui, A.C.-F., Li, P.K.-T., Santamaria, J., MartínezRodríguez, J.E., Iranzo, A.A randomized, placebo-controlled, double-blind, flexibledose study of fluoxetine in the treatment of women with fibromyalgia. Am J Med
2002; 112: 191-197. Double publication
3. Giordano N, Geraci S, Santacroce C, Mattii G, Battisti E, Gennari C. Efficacy and
tolerability of paroxetine in patients with fibromyalgia syndrome: A single-blind study.
Curr Ther Res 1999;60:696-702. Outcomes not suited for analysis
4. Gonzalez-Viejo MA, Avellanet M, Hernandez-Morcuende MI. [A comparative study
of fibromyalgia treatment: ultrasonography and physiotherapy versus sertraline
treatment]Ann Readapt Med Phys 2005;48:610-5. French. Comparison with active
physical therapy
5. Hussain SA, Al-Khalifa II, Jasim NA, Gorial FI. Adjuvant use of melatonin for
treatment of fibromyalgia. J Pineal Res. 2011;50:267-71 Comparison and
combination with melatonin, no placebo control.
6. Ozerbil O, Okudan N, Gokbel H, Levendoglu F. Comparison of the effects of two
antidepressants on exercise performance of the female patients with fibromyalgia.
Clin Rheumatol 25:495-7. No predefined outcomes
7. Sencan S, Karan A, Muslumanoglu L, Ozcan E, Berker E. A study to compare the
therapeutic efficacy of aerobic exercise and paroxetine in fibromyalgia syndrome J
Back Musculoskeletal Rehabil 2004;17:57-61. Comparison with active physical
therapy