FOUNDING TEAM JOSEF M. (JOE) MILLER Cofounder, Chief Scientist Joe is a neuroscientist and a world leader in the field of inner ear research. He’s the Lynn and Ruth Townsend Professor of Communication Disorders at the University of Michigan and an Adjunct Professor at the Karolinska Institutet, Sweden. He’s worked in the area of hearing sciences for more than 30 years, authoring more than 300 peer-reviewed papers. He is the author of the draft federal legislation that established the National Institute on Deafness and Other Communication Disorders (NIDCD) at the U.S. National Institutes of Health (NIH). His major area of research interest is in the neuroscience of the auditory system, including studies on the cochlear prosthesis, blood flow to the inner ear, prevention of noise-induced deafness, and prevention of degeneration and promotion of regrowth of the auditory nerve. He has led major research teams under the National Institutes of Health (NIH) Program Project support and for all of his career has held RO-1 funding for research on studies of the inner ear and CNS. He’s responsible for developing research laboratories and major collaborative research programs between the USA and Europe on studies of tissue engineering of the inner ear and training programs for graduate students and medical residents. Most recently Joe is the editor of the book, Free Radicals in ENT Pathology, Springer 2015. BARRY SEIFER Cofounder, CEO Barry is a former brand strategist, business architect, entrepreneur, consultant and executive in the USA and Europe. He has held design, strategy and management positions at large brand consultancies and ad agencies Landor Associates, Ogilvy & Mather, JWThompson, Omnicom and Interbrand, then operated as independent executive consultant for a dozen years. He holds a Bachelor of Humanities in Philosophy from the University of California at Berkeley, a Master in Fine Arts from Cranbrook Academy of Art, and is a Fellow of the Royal Society of Arts, London. PAUL AALBERTS After his studies at the Haarlem Business School, Paul joined as one of the early employees of IMG Holland, the first online trading brokerage company in the Netherlands, where he held positions in business development, manager of online customer service and wealth management adviser. After that he joined an Amsterdam commercial real estate company, where he closed many transactions and created a large network of high-net-worth clients and broad experience with many companies in different sectors. Team biographies | Revised August 30, 2015 | page 1 FATIH KAHYAOGLU After his economic study at Erasmus University Rotterdam and Michigan State University Fatih started his career as a management trainee at the Dutch Government, which was followed by positions within FMCG companies Red Bull, Diageo and British American Tobacco. In 2007 Fatih joined ID&T and became a shareholder, serving as Chief Commercial Officer for ID&T and Managing Director of Sensation International, one of the leading EDM brands owned by ID&T. During Fatih’s tenure, ID&T grew to be the world’s largest electronic dance music event producer, with events in 28 countries and annual ticket sales of more than 6 million. ID&T’s online music portal beatport.com has more than 50 million unique visitors and more than 15,000 DJs. ID&T is now owned by SFX Entertainment (Nasdaq: SFXE). TACO VAN DER FELTZ Following qualification as Medical Biologist with Honors (Cum Laude) and Medical Doctor (MSc MD) at the University of Utrecht, Taco joined Procter & Gamble Pharmaceuticals in Brand Management. In Holland and Belgium he launched the first in the world bisphosphonate treatment approved for osteoporosis, then moved to P&G Pharmaceuticals (P&GP) in the USA as Medical Director Bone to co-lead the North America product launch. As Global Brand Manager collaborating with R&D teams he was responsible for global commercial strategy on projects ranging from discovery stage to Phase III clinical development. He returned to Holland to lead P&GP’s national sales and marketing organization. In 1997 Taco was appointed as Director of Corporate Marketing for Royal Numico (acquired by Danone in 2007). He led the brand and product portfolios in Baby Food, Medical Nutrition, and Vitamins & Minerals, reporting the CEO and supervising international strategy formulation and implementation. When Royal Numico restructured Taco left to join SNS Reaal as Director Marketing & Communication, then joined Russell Reynolds Associates in Amsterdam as a member of the Global Healthcare Team. He consulted to pharmaceuticals, biotechnology, medical technology, product and platform companies, suppliers and services providers, venture capital companies and their portfolio companies. In 2006 he was elected Managing Director and Partner and set up a new office in Zurich, Switzerland. CECILIA SCOLARO Cecilia develops communication strategies with a focus on digital media. After her studies in Communication design and video making in Milan, she worked in different agencies in guerrilla marketing and digital communications. In 2008 she moved to Holland where she is still supporting startups and corporate companies in various roles that including strategy, branding, marketing, Team biographies | Revised August 30, 2015 | page 2 social media, online communications, campaigns and product management. In 2014 she became an independent consultant and founded Ensembls, the first Collective Social Media platform. MARIEKE HENDRIKSEN VAN DONGEN After her economy and management study she enriched her marketing skills with a Nima C degree. She started her career in the pharmaceutical industry in 2003 with Schering-Plough (MSD) as a hospital account manager. After two years in Sales she moved to Marketing and worked for Pfizer and Abbott Laboratories. As of April 2012 she became Management Team Member and served as Head of Marketing and Customer Relations for the Abbott Diabetes Care Division. In this position she managed 9 FTE and launched two medical devices. With 11 years experience and a proven track record of successful innovative strategies she became an independent consultant in 2013. For the European Head office of Omron Healthcare, she created and implemented the medical marketing campaign in 70 EMEA markets. Most recently she served as a Customer Solution Manager for Merck (MSD). ADVISERS HOWARD HU, M.D., M.P.H., M.S., SC.D. Dr. Hu is Dean and Professor, University of Toronto Dalla Lana School of Public Health. He is a physician-scientist, trained as an internist, occupational and environmental medicine specialist, and epidemiologist. Previous to his July 1, 2012 appointment at U Toronto, Dr. Hu had been Professor at the Harvard School of Public Health and the Channing Laboratory of the Brigham & Women's Hospital in Boston, Massachusetts (1988-2006) and the NSF International Chair of the Department of Environmental Health Sciences and Professor of Environmental Health, Epidemiology & Internal Medicine at the University of Michigan (2006-2012). Dr. Hu is the founder of an environmental epidemiology research group that, since 1990, has grown into a multi-institutional and international team of scientists devoted to gaining new insights into the impacts of exposure to potentially toxicants that are of critical importance to public health and medicine. The team applies multi-disciplinary and novel methods for assessing environmental exposures, genetics/genomics, epigenetics, nutrition, psychosocial factors and clinical measurements in epidemiologic studies of child development and adult chronic disease in populations around the world. With Principal Investigators and major collaborations based mainly at the Harvard School of Public Health, the University of Michigan, the National Institute of Mexico, Sri Ramachandra University (Chennai, India), the Mount Sinai School of Medicine and now the University of Toronto, Dr. Hu and colleagues have a number of on-going projects. Team biographies | Revised August 30, 2015 | page 3 Dr. Hu has published over 240 original papers in the scientific literature and served as the Founding and now Associate Medical Editor of Environmental Health Perspectives, the official journal of the U.S. National Institute of Environmental Health Sciences (NIEHS). His work has won a number of awards, such as the 1999 NIEHS Progress and Achievement Award, the 2006 Harriett Hardy Award, the 2009 Linus Pauling Lifetime Achievement Award, and the 2011 Award of Excellence from the American Public Health Association. Dr. Hu has also served on four factfinding missions and on the Board of Directors for Physicians for Human Rights, and he was the Chair of the Research Commission for the International Physicians for the Prevention of Nuclear War. He currently serves on the National Advisory Environmental Health Sciences Council for the U.S. National Institutes for Health. Dr. Hu received his Sc.B. from Brown University, his M.D. degree from the Albert Einstein College of Medicine and his M.P.H. and Sc.D. degrees (Epidemiology) from the Harvard School of Public Health. He trained in internal medicine at Boston City Hospital and in occupational/ environmental medicine at Harvard. JAMES MULLEN CEO, PATHEON PHARMACEUTICALS Mr. Mullen joined Patheon Inc. in 2011 as CEO and has continuously contributed to the company’s growth. Mr. Mullen led Patheon in 2012 as it acquired Banner Pharmacaps, a market leader in soft gelatin capsule technology. As a result of this acquisition, all of Banner’s manufacturing sites were structured under Patheon’s existing CMO business, aligning to the rest of its global network. In 2013, he led Patheon in a $2.6 billion transaction that merged Patheon with DSM Pharmaceutical Products, creating DPx. Mr. Mullen is also an Officer of DPx Holdings B.V. Prior to joining Patheon, he served as CEO and President at Biogen Idec Inc. from 2003 to 2010, one of the world's largest biotechnology companies. Mr. Mullen was responsible for the merger of Biogen and Idec Pharmaceuticals, serving as CEO and President of Biogen from 2000 to 2002, and Chairman, CEO and President of Biogen until the merger was complete in 2003. Additionally, Mr. Mullen held various operating positions at Biogen prior to becoming CEO, including Vice President, Operations, and several manufacturing and engineering positions over a nine-year period at SmithKline Beecham. Mr. Mullen possesses over 30 years of industry experience, ranging from biotechnology, pharmaceuticals to specialty chemicals, as well as extensive expertise in pharmaceutical and biotech manufacturing, engineering, sales, marketing, mergers and acquisitions. Currently, he serves on the Board of Directors for Perkins Elmer Inc. and as a trustee of The Rivers School. He previously served as Chairman of the Biotechnology Industry Organization. Mr. Mullen holds a Bachelor of Team biographies | Revised August 30, 2015 | page 4 Science in chemical engineering from Rensselaer Polytechnic Institute and a Master of Business Administration from Villanova University. RICHARD ZIJLMA Richard Zijlma is CEO, Amsterdam Dance Event (ADE). ADE is the world’s leading electronic dance music conference and the biggest club festival for electronic music. Founded sixteen years ago, ADE first came to light in 1996 as a small conference with a few hundred music professionals and a festival program in 3 clubs with 30 DJs. ADE has grown to become the ultimate platform to meet international business partners, introduce businesses to a worldwide audience and get in touch with new people, new music and new trends. The annual 5-day ADE Festival in Amsterdam attracts more than 350,000 visitors, 5,000 professionals, 2,500 artists and 460 journalists. The digital reach is in the billions. HERMAN VAN DER ZWAN Herman is an accomplished Dutch music industry executive, starting in 1970 as a marketing manager for the music labels Telefunken (Germany) Barclay (France) and CNR (Dutch). In 1980 he joined WEA (Warner/Elektra/Atlantic joint venture) as A&R Director to build their national artist roster. In 1984 he joined John de Mol Produkties as Managing Director of the artist management company Total Management. From 1987 through 1993 he was Head of the National A&R Department at Phonogram (Universal), heading a team of 8 promotion and marketing people signing and building acts such as De Dijk, The Scene, Laura Fygi, Valensia, BZN, Gerard Joling and the world famous Andre Rieu. RESEARCH COLLABORATORS COLLEEN GARBE LE PRELL PH.D. Dr. Le Prell is Professor and Program Head at University of Texas at Dallas Dr. Le Prell is principal collaborator with Dr. Miller and others in NIH-funded research translating potential therapies from animal models to human trials directed at prevention of noise-induced hearing loss, to identify and prevent the progression of biochemical processes that lead to inner ear cell death. In her role as Dr. Miller’s principal translational research collaborator, Dr. Le Prell was the lead scientist of the initial clinical trials of the technology that became Soundbites. Dr. Le Prell earned her BA in Psychology from the University of Minnesota, and her M.A. and Ph.D. in Psychology from the University of Michigan. She was Research Investigator at University of Michigan, Ann Arbor, Michigan (Department of Otolaryngology, Kresge Hearing Research Institute) after completing her postdoctoral training there. She is author of more than two dozen peer reviewed scholarly journal articles, contributor to six book chapters, and co-inventor on four patents. Team biographies | Revised August 30, 2015 | page 5 GLENN E. GREEN M.D. Medical Supervisor Dr. Green is Clinical Associate Professor of Otolaryngology – Head and Neck Surgery, Division of Pediatric Otolaryngology, University of Michigan. He is co-investigator on NIH-NIDCD U01 DC008423-01A2, “Micronutrient Intervention to Reduce Noise-Induced Hearing Loss", with Principal Investigator Dr. Miller. He collaborates with Dr. Miller on ongoing laboratory and epidemiological studies involving Soundbites. SOPHIA E. KRAMER, PHD Hearing Research Dr. Sophia E. Kramer is Professor in the department of Otolaryngology-Head and Neck Surgery, section Audiology, EMGO+ Institute at the VU University Medical Center Amsterdam, and full professor on the University Research Chair (URC) Auditory Functioning and Participation, after her studies in Neuropsychology and her PhD in Audiology from the VU University in Amsterdam. Her major research interests are in the psychosocial and cognitive aspects related to hearing and hearing impairment in adults, the innovation and evaluation of aural rehabilitation services and the development of methods to measure listening effort. Sophia Kramer is mainly involved in research activities, but is also engaged in clinical work (patient care) at the University Audiology Center of VU Medical Center Amsterdam. She is the principal investigator of the National Longitudinal Study on Hearing (NL-SH). Dr. Kramer has published papers, a book and book chapters on psychosocial, occupational and cognitive aspects of hearing impairment and self-reported outcome measures. She is editorial board member of Trends in Amplification, the International Journal of Qualitative Studies of Health and Wellbeing and Audiology Research and a past-president of the International Collegium of Rehabilitative Audiology (ICRA). RICHARD (RICK) NEITZEL, PHD, CIH Noise Exposure Scientist Rick Neitzel is an exposure scientist and Assistant Professor in the University of Michigan Department of Environmental Health Sciences and its Risk Science Center. His research focuses on the characterization of exposures to noise, heavy metals and other ototoxins, psychosocial stressors, and injury risk factors, as well as a range of adverse health effects associated with these exposures. His work, and the work of his lab team takes place in occupational and community settings both domestically and abroad. He is particularly interested in incorporating new methodologies and exposure sensing technologies into research, and also has a strong interest in translating his Team biographies | Revised August 30, 2015 | page 6 research findings into occupational and public health practice. He has been a Certified Industrial Hygienist (CIH) since 2003 and was named a Fellow of the American Industrial Hygiene Association in 2015. MICHAEL SANTUCCI, AUD Dr. Santucci is founder and president of Sensaphonics; audiologist to many top music performers; and former trustee of American Academy of Audiology Foundation (AAAF). As an ardent music lover, Michael’s life’s work is helping preserve hearing for those whose professions involve exposure to high sound pressure levels. Dr. Santucci invented the in-ear monitor and provides audiological consultation and customized hearing protection to many of today’s top music performers. Dr. Santucci’s in-ear monitors are also used by NASA and the Secret Service, racing drivers and commodities traders. His articles on hearing health have been published in over 40 periodicals. Dr. Santucci has given talks at Columbia School of Audio Engineering, Northwestern University, University of Chicago, the American Academy of Audiology, the Audio Engineering Society, the US Air Force, the GRAMMY® organization (NARAS), American Academy of Dispensing Audiologists, and others. In 1999, his fellow Audiologists voted him to be the first recipient of the Larry Mauldin Award for Excellence in the Hearing Healthcare Field for “exemplifying the highest standards and commitment to the hearing care profession and for pioneering new ideas that change peoples lives.” In 2006, Dr. Santucci was awarded the Natalie Stukas Hearing Conservation Award by the Illinois Academy of Audiology (ILAA) for his untiring dedication to the cause of hearing conservation. He is the past Director of Membership and executive board member of the National Hearing Conservation Association (NHCA). He was a trustee of American Academy of Audiology Foundation (AAAF) from 2008 - May, 2011. MARISKA STAM, PHD Hearing Research Mariska Stam started working as a PhD student at the department of Otolaryngology-Head and Neck surgery, section Ear & Hearing of VU University Medical Center Amsterdam/EMGO+ Institute in September 2010 on the second wave of the National Longitudinal Study on Hearing (NL-SH). The aim of the NL-SH prospective cohort study is to examine the longitudinal relationship between hearing impairment and various aspects of life, such as work, psychosocial health, quality of life and use of health care. Dr. Stam was awarded her PhD in June 2015 on the dissertation entitled "How hearing impairment may impact adult life: Baseline and 5-year followup results of the NL-SH study.” The thesis covers a series of studies each providing news insights into how hearing impairment may impact the lives of adults, and into the determinants and Team biographies | Revised August 30, 2015 | page 7 consequences of a deterioration in speech recognition ability over time. It is the first time that deterioration of speech intelligibility in noise over years was investigated at such a large scale. Currently, Mariska continues her scientific work at the department of Otolaryngology-Head and Neck Surgery, section Ear & Hearing of VU University Medical Center as a post-doctoral researcher co-supervising the NL-SH study and as a Soundbites epidemiological studies co-investigator. ProHearing Consortium Principal Investigators ProHearing is funded by a €5 million grant from the European Commission Public Health Programme. The objective of the grant is to launch an EU SME that successfully commercializes the Soundbites technology throughout the EU and beyond so as to measurably reduce the social and economic burdens associated with hearing loss in the general population. Joe Miller is chief scientist of the ProHearing Steering Committee. Hearing Health Science is the ProHearing SME. JOSE M. (PEPE) JUIZ GOMEZ M.D., PH.D. Dr. Juiz is Professor, Medical Faculty, UCLM, and Director, Neurological Disability Research Institute. Dr. Juiz holds an MD degree from the University of Madrid (Universidad Complutense) and further pursued research training, earning a Ph.D. in Medicine from the University of Alicante in 1987, with a doctoral dissertation on toxic excitatory neuronal death in the cochlea. He has been involved in hearing health research for more than 20 years and has authored more than 50 publications, including journal articles, book chapters and books in the field of auditory neuroscience. THOMAS LENARZ, MD, PH.D. Dr. Lenarz is the director of the ENT clinic at Hannover Medical School, Hannover, Germany, with about 150 employees in the clinic and/or in the corresponding research department. His major research area is the auditory system with focus on auditory prosthesis, hearing preservation, auditory nerve regeneration, and the pharmacology of the auditory system. He is a member of national/international societies of otolaryngology, audiology and skull base surgery and of the Editorial Board of the American Journal of Otology, Otology & Neurotology, Laryngo-RhinoOtology. Prof Lenarz has more than 200 publications in national and international journals. HEIKO VON DER LEYEN, M.D., PH.D. Dr. von der Leyen is Professor of Internal Medicine, managing director and co-founder of HCTC. From 1998 to 2005 Prof. von der Leyen had several Team biographies | Revised August 30, 2015 | page 8 top management positions in the biotechnology industry with focus on the clinical development of advanced therapy medicinal products (tissue engineering, gene therapy, DNA medicine). MATS ULFENDAHL, PH.D. Dr. Ulfendahl is Professor of Experimental Audiology and Otology at Karolinska Institutet. Has published >120 scientific reports on inner ear function, the last decade primarily related to mechanisms underlying deafness and novel therapeutic approaches. Director of the Center for Hearing and Communication Research at Karolinska Institutet 2002-2010. Since 2010 Secretary-General for Medicine and Health at the Swedish Research Council. PARTNERS PATHEON PHARMACEUTICALS | Partner since 2010 Patheon is the world’s leading provider of contract drug development and manufacturing services with an integrated network of facilities across North America, Europe and Australia. To date, Patheon’s labs in Cincinnati, Ohio USA, Milton Park UK, Bourgoin (Lyon) France and Tilburg, Holland have developed and produced four dosage formats and enabled the company to register two dosage forms as clinical medicines in the USA and Germany. IAN BICKERTON HUIJSKENSBICKERTON | Partner since 2013 Ian Bickerton is partner and co-owner at HuijskensBickerton, an independent, specialist communications consultancy in Amsterdam. Ian joined the agency in 2007 from the Financial Times, where he was Netherlands’ correspondent for eight years. Ian and has more than 25 years’ experience as a reporter, including with the Sunday Correspondent and Observer. Ian was a contributing editor to Drapers Record, the international retail fashion trade magazine, and before that a songwriter and recording artist with BMG/RCA records, releasing critically acclaimed works in the UK and US. He currently provides strategic advice to Boards and senior executives at public and private international corporations, including those active in healthcare, retail, financial services and technology. EDWIN SCHMIDHEINY/ACCENT BRANDS | Partner since 2013 Edwin Schmidheiny is a brand designer with international experience developing and managing corporate design systems in the USA, Europe, Middle East, and Asia. He has served as Creative Director at Interbrand and Landor Associates, lived and worked in San Francisco, Moscow, Dubai and Zurich. He has had major roles in brand programs for Nespresso, Esso/Exxon, Fuji, Intel, Team biographies | Revised August 30, 2015 | page 9 BMW, UBS, BASF, Lufthansa, Japan Airlines, Swissair, Korean Air and Thai Airways. He foundedAccent Brand Consultants AG in 2012. The Hearing Health Science and Soundbites brands were developed by Accent. KESSELSKRAMER Partner since 2014 Established in 1996, KesselsKramer is an independent communications agency in Amsterdam, London and now in Los Angeles with about 50 people of 10 different nationalities. They produce some of the most original and engaging work in cross-border business and culture, taking measured risks to make relevant yet irreverent communications that helps drive business, build loyal communities and reshape minds. Seriously. Team biographies | Revised August 30, 2015 | page 10