CURRICULUM VITAE
NAME:
Fulton T. Crews
ADDRESS:
Director, Bowles Center for Alcohol Studies
John Andrews Distinguished Professor
Professor of Pharmacology & Psychiatry
Skipper Bowles Center for Alcohol Studies
CB# 7178, Thurston-Bowles Building
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27599-7178
919•966•5678 or FAX: 919•966•5679
Email: ftcrews@med.unc.edu
Internet: http://www.med.unc.edu/alcohol
EDUCATION:
1971 B.S., N.Y. State Regents Scholar
Syracuse University
1978 Ph.D., Pharmacology
Rackham Graduate School
University of Michigan
Professional and Research Experience:
2008-Present
1999-Present
1994-Present
1994-Present
1994-Present
1992-1994
1990-1994
1990-1994
1985-1990
1980-1985
John R. Andrews Distinguished Professorship
Professor of Curriculum in Toxicology
University of North Carolina at Chapel Hill
Director, Skipper Bowles Center for Alcohol Studies
University of North Carolina at Chapel Hill
Professor of Pharmacology and Psychiatry
University of North Carolina at Chapel Hill
Courtesy Professor Pharmacology and Therapeutics
The University of Florida
Co-Director, Center for Alcohol Research
The University of Florida
Co-Director, Center for Neurobiology of Aging
The University of Florida
Professor, Department of Pharmacology,
College of Medicine
The University of Florida
Associate Professor, Department of Pharmacology,
College of Medicine
The University of Florida
Assistant Professor, Department of Pharmacology,
Curriculum Vitae
Fulton T. Crews
Page 2
1978-1980
1973-1978
1972-1973
Revised 1/7/2014
College of Medicine
The University of Florida
N.I.H. Pharmacology Research Associate Award
PRAT Fellow (Preceptor: Julius Axelrod, Ph.D.),
National Institute of Mental Health, Bethesda, Maryland
Graduate Student, Department of Pharmacology,
The University of Michigan, Ann Arbor,
Michigan. Advisor: C.B. Smith, M.D./Ph.D.
ENDO LABS: Research Associate with Dr. Harold Blumberg
Worked on the development of Naloxone.
Professional Societies:
National Association of Alcoholism and Drug Abuse Counselors
American College of Neuropsychopharmacology (Associate Member)
American Association for the Advancement of Science
American Society for Pharmacology and Experimental Therapeutics
International Society for Neurochemistry
New York Academy of Sciences
Research Society on Alcoholism
Society for Neuroscience
International Society for Biomedical Research on Alcoholism
Collegium Internationale Neuro-Psychopharmacologicum
International Society for Biomedical Research on Alcoholism
European Society for Biomedical Research on Alcoholism
Awards and Honors:
2014 Key Note Speaker, European Behavioral Pharmacology Society (June2014)
2011 Member NIAAA Advisory Council
2011 ACNP Fellow, American College of Neuropsychopharmacology
2009 Okey Memorial Lecture: Psychiatry Research Trust, London England 11/17/09
2009 Salzburg Plenary Lectureship, Austrian Neuroscience Association, Salzburg 9/18/09
2009 Stanley Marsh III Endowed Lectureship, University of Texas. 6/16-17/09
2008 Plenary Speaker USA-Japan Workshop on Alcoholism, Yokohama, Japan
2008 Received John R. Andrews Distinguished Professorship
2007 Distinguished Investigator Award for Scientific Excellence, Research Society on
Alcoholism, Chicago, Illinois
2007 Guze Lectureship Award – Washington University, St. Louis
2006 Mark Keller Honorary Lecturer, National Institutes of Health Clinical Center
2006 Bowles Lectureship Award, CAS, University of North Carolina at Chapel Hill
2006 Grass Lectureship Award, US Society for Neuroscience grant to University of
Alaska Fairbanks
2004-2012, Chair, External Advisory Board to NIAAA Council for Strategic Planning.
2004 Member Neuroscience Blue Print Advisory Panel, National Institutes of Health
2003 Norbert Kelly Distinguished Award for Contribution to Understanding Addiction as
a Mental Disease, Addiction Professionals of North Carolina, Pinehurst N.C.
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2003 Forbes Lectureship, Grass Foundation Award, Chicago Chapter of Neuroscience
2002 NIH Grand Rounds
2001 Received the University of Michigan Outstanding Alumnus Award
1992-1993 Top 100 Researchers, University of Florida
(Chosen by the University of Florida's Division of Sponsored Research
from over 3000 faculty)
1991-1992 Top 100 Researchers, University of Florida
1990 University of Florida Merit Teaching Award
1989-1990 Top 100 Researchers, University of Florida
1988-1989 Top 100 Researchers, University of Florida
1987-1988 Top 50 Researchers, University of Florida
1987, 2002 Grass Traveling Scientist
1978-1980 Pharmacology-Toxicology Research Associate Fellowship
National Institute of Mental Health
1973-1978 N.I.H. Predoctoral Training Fellowship
University of Michigan
1968-1972 New York State Regents Scholarship
Syracuse University
Consultant - Advisory Boards:
Member NIAAA Advisory Council 2011- present
NIH Neuroscience Blue Print Advisory Panel
Bethesda, MD, 2004-present
Chair, NIAAA Extramural Advisory Board for Strategic Planning
NIAAA, 2004-2012
External Advisory Board
Alcohol Research Center
Thomas Jefferson, University, 2002-present
Scientific Advisory Board
Alcohol Center Grant, The Scripps Research Institute, Department of
Neuropharmacology, La Jolla, California, 2002-Present
Internal Advisory Board
Drug Dependence Center: Behavioral/Genetic Correlates, University of North
Carolina at Chapel Hill, 2002
Chair, External Advisory Board, University of Alaska Fairbanks,
Alaskan Basic Neuroscience Program, 2001 – 2006
National Institute on Drug Abuse Advisory Committee 1998
Alcohol/Drug Council of North Carolina 1997 – present
Agency: NIH-DRG
Study Section/Review Panel: ALTX3-Alcohol and Toxicology Study Section
Term: Feb. 96 Guest Reviewer for integration of study section into DRG from NIAAA
Study Section/Review Panel: ALCB2- Alcohol Study Section Term: Feb. 93 -June 95
Agency: NIH-NIAAA
Study Section/Review Panel: Merit Award Review Committee -NIAAA Council
Term: Sept. 21, 1995
Board of Directors, Freedom House, 1995-2001
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Board of Directors, NC Governor’s Institute for Alcoholism and
Substance Abuse, 1995-Present
Board of Directors, Research Society on Alcoholism, 1995 to Present
Board of Directors, Division of Sponsored Research, Univ. of Fla., 1991-1994
National V.A. Merit-Grant Review Committee
Veterans Affairs Merit Review Board: Alcoholism and Drug Dependence,
Member 1991-1994
Chairman 1993-1994
Executive Secretary: Joe Webster, Ph.D.
NIH Study Section: Alcohol Biomedical Research Review Committee
Neuroscience and Behavior Subcommittee (ALCB-2)
NIAAA Scientific Review Administrator: Antonio Noronha, Ph.D.
1991-1995
Biochemistry, Physiology and Medicine Subcommittee
Alcohol Biomedical Research Review Committee (ACLB-1)
Ad-hoc Reviewer, Exec. Sec: Ron Suddendorf, Ph.D.
Feb. 1991
Scientific Advisory Committee
Integra Institute, Bethesda, MD
1988-1994
Expert Testimony. United States Senate, Washington, D.C., May, 1987
Progress in Alcohol Research
NIMH Study Section. Psychopathology and Clinical Biology
(PCB-2). September, 1989-1990
Executive Secretary: Jay Cinque
Alzheimer's Association. Grant Reviewer. 1990-Present
V. A. Grant Reviewer 1989-1990
NIAAA Ad-hoc Reviewer July, 1990
Pittsburgh Alcohol Research Center, Site Visit and Review
Exec. Sec.: Dr. Mike Lewis July. 1990
NIAAA Study Section Nov. 1989
Ad-hoc Reviewer
Phoenix, Arizona
Exec. Sec.: Dr. Sam Zachary
NIAAA Ad-hoc Reviewer
ALCB-1 May 1988
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Fulton T. Crews
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Exec. Sec.: Dr. Ron Suddendorf
LABORATORY ALUMNI of Dr. Fulton T. Crews:
Post-Doctoral Fellows:
1.
Ryan Vetreno, Ph.D.
(2011-present)
Research Associate
Center for Alcohol Studies
UNC-Chapel Hill
2.
Liya Qin, Ph.D.
(2003-present)
Research Associate
Center for Alcohol Studies
UNC-Chapel Hill
3.
Jian Zou, M.D., Ph.D.
(2001-present)
Research Associate
Center for Alcohol Studies
UNC-Chapel Hill
4.
Jun He, M.D., Ph.D.
(2003-2008)
Resident in Psychiatry
UNC-Chapel Hill
5.
Olivera Pluzarev, MD PhD
Associate Medical Director
Medical Affairs, Kendle International, Inc
4024 Stirrup Creek Drive, Suite 700
Durham, NC 27703
6.
Kim Nixon, Ph.D.
(2000-2005)
Assistant Professor
Department of Pharmaceutical Sciences
The University of Kentucky
7.
Alexander Mdzinarishvili, Ph.D.
(2001-2003)
Assistant Professor
Pharmaceutical Sciences
College of Medicine and Pharmacy
Revised 1/7/2014
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Fulton T. Crews
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Northeastern Ohio University
8.
Silvia Bison, Ph.D.
(1999-2002)
Staff Scientist
Glaxo Welcome
Verona, Italy
9.
Blair Hoplight, Ph.D.
(1999-2001)
Research Associate
University of Washington
10.
Alexei Kampov-Polevoi, M.D., Ph.D.
(1998-2000)
Assistant Professor
Mt. Sinai School of Medicine
11.
Darin Knapp, Ph.D.
(1995-1996)
Assistant Professor
Department of Psychiatry
UNC – Chapel Hill
12.
Prabu Ayyagari, Ph.D.
(1994-1997)
Executive Project Manager
WebSphere Services
IBM Software Group
Somers, NY
13.
Elena Bingaman-Cleary, Ph.D.
(1994-1996)
Director, Medical Writing
Schwartz BioSciences, Inc.
Research Triangle Park, NC
14.
Heni Hartmann, Ph.D.
Department of Neurology
Harvard medical School
Boston, MA
15.
M.R. McElhaney, D.V.M.
Assistant Professor
Department of Pathology
University of California, Davis
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Fulton T. Crews
Page 7
Sacramento, CA
16.
Nicolas Guzman, M.D.
Associate Professor of Medicine
The George Washington University
Washington, DC
17.
L.J. Chandler, Ph.D.
Professor of Pharmacology
Medical University of South Carolina
Charleston, SC
18.
Norbert Pontzer, Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325
Rockville, MD 20852
19.
Jaime Puig, Ph.D.
Professor of Pharmacology
Ponce College of Medicine
Ponce, Puerto Rico 00732
20.
Rueben Gonzales, Ph.D.
Professor of Pharmacology
University of Texas
Austin, TX
21.
Neelam Narang, Ph.D
Asst. Professor of Pharmacology
University of North Dakota Medical School
Fargo, ND 58102
22.
Ramesh Chander, Ph.D.
Scientific Officer
F.T.E.E. Div., FIPLY
Bhabha Atomic Research Center
Bombay – 400085, India
23.
Gabriella Calderini, Ph.D.
Director of Bioskin Research
Fidia Research Laboratories
35031 Abano Term, Italy
Graduate Students - Chairman of Dissertation Committee:
Revised 1/7/2014
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Fulton T. Crews
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1.
Leon Coleman, M.D. Ph.D. program
(2008-2010)
Resident (defending Ph.D. 7/15/10)
UNC – Chapel Hill
2.
Peter Nicholas, M.D., Ph.D.
(2004-2007)
Internal Medicine Resident
Moses Cone Hospital
Greensboro, NC
3.
Jennifer Obernier, Ph.D.
(1995-2001)
National Academies of Science
Study Director
Institute for Laboratory Animal Research
Washington, DC
4.
Joseph Rudolph, Ph.D.
(1992-1998)
Division of Neuroscience, Development and Aging Chief
Emerging Technologies and Training in Neurosciences (ETTN)
NIH/CSR
5.
Vincent Andaloro, Ph.D.
(1990-1994)
Executive Dir. Bioanalytical Business Development
PPD, Inc
6.
Rajiv Patel, M.D., Ph.D.
Emory Healthcare
7.
James Scott, M.D. Ph.D.
Staff Fellow
NINCDS, National Institute of Health
Bethesda, MD
8.
Robert Raulli, Ph.D.
Foresight Science and Technology
9.
Anne Heiman, Ph.D.
Professor of Pharmacology
Florida A & M University
Tallahassee, FL
Thesis Committee Member:
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Revised 1/7/2014
Leon Coleman, Ph.D. Candidate, 2010 (Neurobiology)
Michael Salling, Ph.D. Candidate, 2010 (Neuroscience)
Jennie Hillman, Ph.D. 2009 (Neurobiology)
Kevin Boyd, Ph.D. 2009 (Toxicology)
Amanda Sharko, PhD. 2008 (Pharmacology)
Rebekah Fleming, Ph.D. 2005 (Neurobiology)
Shannon Penland, Ph.D., 2005 (Pharmacology)
Carla (Jan) Smith, Ph.D. Candidate, 2001 (Cell & Developmental Biology)
Jason Kralic, Ph.D., 2002 (Pharmacology)
William Dunty, Ph.D., 2001 (Cell & Developmental Biology)
Maggie VanDoren, Ph.D., 2001 (Neurobiology)
Mike Wheeler, Ph.D., 2000 (Pharmacology)
Robin Ali, MD/PhD, 2000 (MD)
Chris Konkoy, Ph.D., 1992 (Pharmacology)
Hee-Sun Yang, Ph.D., 1992 (Medicinal Chemistry)
Bismarck Amoah-Apraku, 1992 (Pharmacology)
Dayna J. Clarke, Ph.D. 1991 (Pharmacology)
Roger Marckel, Ph.D. 1991 (Pharmacology)
Nelida Sjak-Shie, Ph.D. 1991 (Pharmacology)
Christine Hughes, Ph.D. 1991 (Psychology)
David Robert Wallace, Ph.D., 1990 (Pharmacodynamics)
Christine E. Hughes, Ph.D., 1990 (Psychology)
Christoph S. Konkoy, Ph.D., 1990 (Pharmacology)
Eileen Joan Martin, Ph.D., 1990 (Pharmacology)
Carolyn P. Bolden, Ph.D., 1989 (Pharmacology)
James Scott, 1989 (Medicinal Chemistry)
Kelly M. Standifer, Ph.D., 1988 (Pharmacology)
Cathy D. Smith, Ph.D., 1988 (Pharmacodynamics)
Shari McArdle, Ph.D., 1988 (Pharmacology)
Denise F. Bottiglieri, Ph.D., 1985 (Pharmacology)
James L. Ferrero, Ph.D., 1984 (Pharmacology
Carol A. Nelson, Ph.D., 1984 (Pharmacology)
Sally J. Wechsler, Ph.D., 1983 (Veterinary Pathology)
James W. Doyle, Ph.D., 1982 (Pharmacology)
Other Students and technicians who have gone on to independent careers:
1.
Erin Potts
Duke University Medical School
Research Analyst – Pulmonary Department
2.
Richard Hanes, 1995-2001
Research Specialist
NIEHS
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3.
Chris Braun, 1996-2001
Technician
Thermogenicimaging
4.
Vijay Sivaraman, 2000
University of South Florida
Carolina Summer Fellowship Program
5.
Kathleen McGinley, 1999
Chestnut Hill College, Philadelphia
Carolina Summer Fellowship Program
6.
Michael Beachem, 1998-2000
Undergraduate Student
University of North Carolina at Chapel Hill
7.
Pratik Patel, 1997
New York University
Carolina Summer Fellowship Program
8.
Eric Frey, 1996
University of North Carolina at Chapel Hill
Carolina Summer Fellowship Program
9.
Matt Rill, 1991-1994
Medical Student
University of Florida
10.
Mark Gerber, 1991-1994
Medical Student
University of Florida
11.
Alexander VanderVeen, M.D.
Practicing Physician
Netherlands
12.
Englebert Tjeenk Willink, M.D.
Clinical Research, DUPHAR B.V.
Mathernesserlaan 259
3021 HD
Rotterdam, Netherlands
13.
Cindy Theiss, M.D.
1990 Graduate University of Miami Medical School
Residency, University of Pennsylvania
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14.
Neal Shorstein, M.D.
Resident Ophthamology
College of Medicine, University of Florida
15.
Rebecca McElhaney
Graduating Class of 1991
University of Florida Veterinary School
16.
Nicholas Kiedam, M.D.
Practicing Physician
Huize Nieuw Hooidrift
Van Vollenhovenstradt
3016 De Rotterdam, Netherlands
17.
Phil Greger
Graduating Class of 1991
University of Miami Medical School
Surgeon, Houston, TX
18.
Neil Ganz
Graduating Class of 1991
University of Colorado Dental School
Revised 1/7/2014
Academic Responsibilities:
University of North Carolina at Chapel Hill:
TEACHING 12-13
Medical Student Substance Abuse Day- 2 hrs.
Medical Pharmacology, 2 hrs. NSAID and Ethanol
Graduate: Principles of Pharmacology, Anxiolytics and Anticonvulsants, Glutamate and GABA.
TEACHING 11-12
Medical Student Substance Abuse Day- 2 hrs.
Medical Pharmacology, 2 hrs. NSAID and Ethanol
Graduate: Principles of Pharmacology, Anxiolytics and Anticonvulsants, Glutamate and GABA.
Psychiatry Residents: Neurobiology of Alcoholism
TEACHING 10-11
Medical Student Substance Abuse Day- 2 hrs.
Medical Pharmacology, 2 hrs. NSAID and Ethanol
Graduate: Principles of Pharmacology, Anxiolytics and Anticonvulsants, Glutamate and GABA.
Psychiatry Residents: Neurobiology of Alcoholism
TEACHING 09-10
Medical Pharmacology, 2 hrs. NSAID and Ethanol
Graduate: Principles of Pharmacology, Anxiolytics and Anticonvulsants, Glutamate and GABA.
Psychiatry Residents: Neurobiology of Alcoholism
TEACHING 08-09
Medical Pharmacology, 2 hrs. NSAID and Ethanol
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Graduate: Principles of Pharmacology, Anxiolytics and Anticonvulsants, Glutamate and GABA.
Psychiatry Residents: Neurobiology of Alcoholism
TEACHING 07-08
Medical Pharmacology, Spring 08, 1hr; Principles of Pharmacology, Spring 08, 2hrs
TEACHING 06-07
Medical Pharmacology, Spring, 07, 2hrs; Pharmacology Carolina Summer Fellows Lecture, 1hr
TEACHING 05-06
Medical Pharmacology, Spring 06, 2 hrs; Pharmacology Carolina Summer Fellows Lecture, 1hr
TEACHING 04-05
Pharmacology Carolina Summer Fellows Lecture, 1hr; Medical Pharmacology, Spring 05, 2 hrs.
Neurobiology 228, Fall 05, 2hrs
TEACHING 03-04
Neurobiology 228, Fall 03, 2 hrs; Medical Pharmacology 223, Spring 04, 2 hrs.
TEACHING 02-03
Pharmacology 202, Spring 03, 2 hrs; Nutrition 323, Spring 03, 2 hrs; Medical Pharmacology,
Spring 03, 2 hrs; UNC Medical Students Substance Abuse Lecture Series, 1 hr; Psychiatry
Residents Substance Abuse Lecture, 1hr
TEACHING 01-02
Pharmacology 202, Spring 02 -2 hrs; Nutrition 323, Spring 02, 2 hrs; Medical Pharmacology,
Spring 02, 2 hrs; UNC Medical Students Substance Abuse Lecture Series, 1 hr
TEACHING 00-01
Dental Pharmacology, Fall 2000 -3 hrs.; Medical Pharmacology, Spring 01, 2 hrs.;
Neuropharmacology of Alcohol and Drug Abuse, Spring 01, 2 hrs.; UNC Medical Students
Substance Abuse Lecture Series, 1 hr
TEACHING 99-00
Dental Pharmacology, Fall 1999 - 3 hrs.; Medical Pharmacology, Spring 00, 2 hrs.; Nutrition,
Spring 00, 2 hrs.; Neuropharmacology of Alcohol and Drug Abuse, Spring 00, 2 hrs.; UNC
Medical Students Substance Abuse Lecture Series, 1 hr
TEACHING 98-99
Dental Pharmacology, Fall 1998 - 3 hrs.; Medical Pharmacology, Spring 99, 2 hrs.;
Neuropharmacology of Alcohol and Drug Abuse, Spring 99, 2 hrs.; UNC Medical Students
Substance Abuse Lecture Series, 1 hr
TEACHING 97-98
Dental Pharmacology, Fall 1997 - 6 hrs.; Medical Pharmacology, Spring 98, 2 hrs.; Nutrition,
Spring 98, 2 hrs.; Neuropharmacology of Alcohol and Drug Abuse, Spring 98, 2 hrs.; UNC
Medical Students Substance Abuse Lecture Series, 1 hr.; Mini Med School-The Miracle of Life
and the Curse of Addiction, Spring 98.
TEACHING 96-97
Dental Pharmacology, Fall 1996 - 8 hrs.; Medical Pharmacology, Spring 97, 2 hrs.; Nutrition,
Spring 97, 2 hrs.; Neuropharmacology of Alcohol and Drug Abuse, Spring 97, 2 hrs.; UNC
Medical Students Substance Abuse Lecture Series, 1 hr.; Mini Med School-Neurobiology, the
Brain & Addiction, Spring 1997.
TEACHING 95-96
Dental Pharmacology, Fall 1995 - 7 hrs.; Medical Pharmacology, 95-96, 2 hrs.; Graduate
Pharmacology 2 hrs.; Biomedical Science Selective: Neuropharmacology of Alcohol and Drug
Abuse, UNC Medical Students Substance Abuse Lecture Series, 2.5 hrs.;
Mini Med School-Alcohol and the Brain, Spring 1996.
University of Florida, Gainesville, Florida:
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Course Chairman, Junior Honors Pharmacology, 1981-1983; 1991-1994. Responsible for honors
student course involving ten weeks of lectures to Honors medical students.
Course Chairman, Pharmacology and Therapeutics Course, College of Medicine, 1987-1990.
Responsible for organizing 96 hour course and for examining and giving grades to
approximately 120 medical and graduate students. Directly responsible for approximately 15
hours of lecture and 18 hours of small group sessions.
Course Chairman, Autonomic and Cellular Pharmacology graduate course, 1985-1986.
Responsible for organizing 25 hour courses for 15 graduate students.
Course Chairman, Pharmacology for Pharmacy Students, 1983-1985.
Responsible for organizing 2 semester 120 hour course and for examining students and giving
grades to approximately 90 students. Directly responsible for 15-22 hours of lecture.
Pharmacology Seminar Program Fall 1981; Spring 1982, Spring 1983
Committees:
Multidisciplinary Advisory Committee for NIH Roadmap K12 Program
Spring 2006
Chair, Dr. Joseph Piven, Director UNC Neurodevelopmental Disorders Research Center
5 year administrative review
Fall 2005
Psychiatry Chairman Search Committee
University of North Carolina at Chapel Hill
2004, Chapel Hill, North Carolina
Member of the Editorial Board
2004, Alcoholism: Clinical and Experimental Research
Chair, Thomas McCown Promotion Committee
2003, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Chair, Evaluation Committee
National Institute on Drug Abuse (NIDA), 2002-present
Member of the External Advisory Board
2002, Alcohol Research Center
Thomas Jefferson University
Philadelphia, PA
Chair, Finance Committee
2003, Research Society on Alcoholism (RSA)
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Chair, J.C. Garbutt Promotion Committee
2001, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
NC Research to Practice (NCRTP) Advisory Board
2000, Research Triangle Park, NC
Editorial Advisory Board
Betty Ford Center quarterly newsletter Findings
1999, Rancho Mirage, CA
Co-Chair, Government Affairs and Advocacy Committee (GAAC)
1999-2000, Research Society on Alcoholism (RSA)
Medical School Y2K Assessment Review Committee
1999, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
President, Alcohol/Drug Council of North Carolina
1999-2001, Durham, North Carolina
Chair, Department of Psychiatry and Center for Alcohol Studies Search Committee
1998, University of North Carolina at Chapel
Chapel Hill, North Carolina
Administrative Board of the School of Medicine
1998-99, University of North Carolina at Chapel
Chapel Hill, North Carolina
Task Force for the Drug and Alcohol Abuse Prevention Program
1998-99, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Task Force for the Center for Science in the Public Interest
1998, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Chancellor’s Task Force on Substance Abuse
1996-97, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
John J. Abel Award Selection Committee
1997, ASPET
Bethesda, Maryland
Grant Application Reviewer
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1996-97, Medical Research Council of Canada
Ottawa Canada
Dean’s Special Equipment Allocation Committee
1996-98 University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Advisory Committee of the School of Medicine
1996-present, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Committee to Implement a Rate Increase for the DLAM
1996-97, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Pharmacology Teaching Committee
1996-1997, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Neurosciences Program Recruitment
Fall 1996, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Minority Cohort Recruitment
Fall 1996, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Chair, Search Committee Pharmacology/CAS UNC-CH
Dr. Lian Li recruited, Chairman, Center for Alcohol Studies - Pharmacology Search
Committee - 1995, University of North Carolina at Chapel Hill
Chapel Hill, North Carolina
Chairman, Pharmacology Search Committee 1992
Drs. Roger Papke and Jeffery Harrison selected and recruited
University of Florida, Gainesville, Florida
Facilities Task Force Strategic Planning Committee, College of Medicine, 1991
Gainesville, Florida
Associate Professor Tenure and Promotion Committee,
College of Medicine, 1991-1994
University of Florida, Gainesville, Florida
Research Society on Alcoholism Meeting Organizing Committee, 1991
University of Florida, Gainesville, Florida
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Psychiatry Chairman Search Committee 1991
Dr. Dwight Evans selected and recruited
University of Florida, Gainesville, Florida
Executive Committee, Center for the Neurobiology of Aging 1989-1994
Co-Director 1990-1994
University of Florida, Gainesville, Florida
Psychiatry Chairman Search Committee 1990
University of Florida, Gainesville, Florida
Executive Committee, Gerontology, Research Education and
Clinical Center 1989-1994
University of Florida, Gainesville, Florida
Executive Committee, Alcohol Research Center, 1984-1994
University of Florida, Gainesville, Florida
Gold Family Symposium Committee 1990
University of Florida Faculty Senate 1987-1989
Coordinated and organized Grand Rounds in the Biology of Disease 1989
Member - Faculty Representative, Campus Alcohol and Drug Resource Center, Office
for Student Services, 1988
College of Medicine Faculty Council 1982, 1983, 1984, 1985;
Department Representative:
Council Representative to Basic Science Board College of Medicine
1982-1984
Initiated Faculty Research Day. Had the first poster boards constructed at the Health
Center and ran Faculty Research Day for the first 3 years. Approximately 100 abstracts
and posters per year 1984-1986. Faculty Research Day continues as an annual Faculty
Council function.
College of Pharmacy Search Committee 1984
Neuroscience Curriculum Review Committee 1984
Clinical Pharmacology Search Committee 1983
Pharmacodynamics Search Committee 1983
Medical Student Research Program Committee, M.D., Ph.D. Program
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Committee 1983
Junior honors in Pharmacology class 1981-1983
Directed, with another faculty member a class of approximately 15 outstanding
undergraduate students.
Vet. Pharm. Search Committee 1982
Pharmacology Search Committee 1982
Cell Biology Committee
Graduate Studies committee in Pharmacology 1983-1986 admissions and recruitment
BIBLIOGRAPHY
1.
ZOU, J., CREWS, FT. Release of Neuronal HmGB1 by Ethanol Through Decreased
HDAC Activity Activates Brain neuroimmune Signaling, PLoS One, In Press 8/12/13
2.
COLEMAN, L., LIU, W., OGUZ, I, STYNER, M., CREWS, FT. Adolescent binge
ethanol treatment alters adult brain regional volumes, cortical extracellular matrix
protein and behavioral flexibility. Pharmacology, Biochemistry and Behavior, In press.
3.
QIN, L, CREWS, FT., Focal thalamic degeneration from ethanol and thiamine
deficiency is associated with neuroimmune gene induction, microglial activation, and
lack of monocarboxylic acid transporters, Alcohol Clin Exp Res. 2013 Oct 11. PMID:
24117525.
4.
OGUZ I, YAXLEY R, BUDIN F, HOOGSTOEL M, LEE J, MALTBIE E, LIU W,
CREWS FT, Comparison of magnetic resonance imaging in live vs. post mortem rat
brains. PLos One. 2013 Aug 13;8(8):e71027. PMID: 23967148
5.
WHITMAN BA, KNAPP DJ,WERNER DF, CREWS FT, BREESE GR. The Cytokine
mRNA Increase Induced by Withdrawal from Chronic Ethanol in the Sterile
Environment of Brian is Mediated by CRF and HMGB1 Release. Alcohol Clin Exp Res.
2013 July 29. PMID: 23895427
6.
VETRENO, RP, QIN, L, CREWS, FT. Increased Receptor for Advanced Glycation
End Product Expression in the Human Alcoholic Prefrontal Cortex is Linked to
Adolescent Drinking. Neurobiology of Disease, 2013 Nov; 59:52-62. PMID: 23867237
7.
EHLERS CL, OGUZ I, BUDIN F, WILLS DN, CREWS FT. Peri-adolescent ethanol
vapor exposure produce reductions in hippocampal volume that are correlated with
deficits in prepulse inhibition of the startle. Alcohol Clin Exp Res. 2013 Sep;
37(9):1466-75. PMID: 23578102
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8.
EHLERS, CL., LIU, W., WILLS, DN, CREWS, FT. Periadolescent ethanol vapor
exposure persistently reduces measures of hippocampal neurogenesis that are
associated with behavioral outcomes in adulthood Neuroscience, 2013 Aug 6;244:2-15.
PMID: 23567812
9.
QIN, L., LIU, Y., HONG, J., CREWS, FT. NADPH oxidase and aging drive microglial
activation, oxidative stress and dopaminergic neurodegeneration following systemic
LPS administration, Glia 2013, Jun;61(6):855-68. PMID: 23536230
10.
CREWS, FT., QIN, L., SHEEDY, D., VETRENO, RP., ZOU, J. High mobility group
box 1/Toll-like Receptor Danger Signaling Increases Brain Neuroimmune Activation in
Alcohol Dependence, Biological Psychiatry 2013 Apr 1;73(7):602-12. PMID:
23206318
11.
CREWS, FT. Immune function genes, genetics, and the neurobiology of addiction.
Alcohol Res. 2012;34(3):355-61. PMID: 23134052
12.
VETRENO, RP., CREWS, FT., Adolescent Binge Drinking Increases Expression of
the Danger Signal Receptor Agonist HMGB1 and Toll-like Receptors in the Adult
Prefrontal Cortex, Neuroscience 2012 Dec 13;226:475-88 PMID:22986167
13.
QIN L, CREWS FT. Chronic ethanol increases systemic TLR3 agonist-induced
neuroinflammation and neurodegeneration. J Neuroinflammation. 2012 Jun 18;9:130.
PMID: 22709825
14.
ZOU, J., CREWS, FT., Inflammasome IL-1 signaling mediates ethanol inhibition of
hippocampal neurogenesis, Frontiers in Neuroscience, 2012; May 30;6:77 PMID:
22661925
15.
COLEMAN, LEON G., OGUZ, IPEK, LEE, JOOHWI, STYNER, MARTIN and
CREWS, FULTON T., Postnatal day 7 ethanol treatment causes persisten reduction
in adult mouse brain volume and cortical neurons with sex specific effect on
neurogenesis, Alcohol, 2012 Sep; 46(6):601-12. PMID:22572057
16.
ZOU, J., VETRENO, RP., CREWS, FT. ATP-P2X(7) Receptor Signaling Controls
Basal and TNF-stimulated Glial Cell Proliferation. Glia, 2012 Apr; 60(4):661-73.
PMID: 22298391
17.
QIN, L, CREWS, FT. NADPH Oxidase and Reactive Oxygen Species Contribute to
Alcohol-Induced Microglial Activation and Neurodegeneration. J. Neuroinflammation,
2012 Jan 12; 9:5 PMID: 22240163
18.
HASHEMI, P., WALSH, P., GUILLOT, T., GRAS-NAJJAR, J., TAKMAKOV, P.,
CREWS, F., WIGHTMAN, R. Chronically Implanted, Nafion-Coated, Ag/AgC1
Reference Electrodes for Neurochemical Applications, Chemical Neuroscience 2011
Nov 16:2(11):658-666. PMID: 22125666
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19.
KOOB, G., CREWS, FT., HARRIS RA., Neuroimmune Signaling and Addiction:
Persistent Interactive Pathology, Nature Neuroscience (NN-R41053), Submitted June
2012
20.
EHLERS, CL., CRIADO, JR., WILLS, DN., LIU, W. and CREWS, FT.
Periadolescent ethanol exposure reduces adult forebrain ChAT+IR neurons:
correlation with behavioral pathology, Neuroscience, 2011, 199:333-45 PMID:
22033458
21.
CREWS, FT., VETRENO, RP, Addiction, adolescence, and innate immune gene
induction, Frontiers in Psychiatry, 2011, April 2(19) PMID: 21629837
22.
CREWS, F.T., ZOU, J., QIN L., Induction of Innate Immune Genes in Brain Create
the Neurobiology of Addiction, Brain, Behavior and Immunity, 2011 Jun; 25 Suppl
1:S4-S12, PMID: 21402143
23.
COLEMAN, L.G., HE, J., LEE, J. STYNER, M. and CREWS, F.T., Adolescent Binge
Drinking Alters Adult Brain Neurotransmitter Gene Expression, Behavior, Brain
Regional Volumes, and Neurochemistry in Mice, Alcoholism: Clinical and
Experimental Research, 2011, Jan 11.doi:10.1111/j.1530-0277.2010.01385x. [Epub
ahead of print] PMID: 2122304
24.
WHITE, H.R., MARMORSTEIN, N.R., CREWS, F.T., BATES, M.E., MUN, E.Y.,
LOEBER, R., Associations between heavy drinking and changes in impulsive behavior
among adolescent boys, Alcohol Clin. Exp. Res., 2011 Feb;35(2):295-303, PMID:
21073485
25.
LIU, Y., LO, Y., QIAN, L., CREWS, F., WILSON, B., CHEN, H., WU, H., CHEN, S.,
WEI, K., LU, R., ALI, S. and HONG, J., Verapamil Protects Dopaminergic Neuron
Damage Through a Novel Anti-inflammatory Mechanism by Inhibition of Microglial
Activation, Neuropharmacology, 2011 Feb-Mar; 60(2-3):373-80, Epub 2010 Oct. 13,
PMID: 20950631
26.
HANSSON, A., NIXON, K., RIMONDINI, R., DAMADZIC, R., SOMMER, W.,
ESKAY, R, CREWS, F.T., HEILIG, M. Long-term suppression of forebrain
neurogenesis and loss of neuronal progenitor cells following prolonged alcohol
dependence in rats. Int J Neuropsychopharmacol. 2010 Jun;13(5):583-93 PMID:
20334723
27.
ZOU, J., CREWS, F.T. Induction of Innate Immune Gene Expression Cascades in
Brain Slice Cultures by Ethanol: Key Role of NF-kappaB and Proinflammatory
Cytokines. Alcohol Clin Exp Res. 2010, 34(5):777-89, Epub 2010 Mar. 3 PMID:
20201932
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28.
DUKA, T., CREWS, F.T. Impulsivity: Its genetic, neurochemical and brain substrate
determinants and the risks it entails for aberrant motivated behavior and
psychopathology, Pharmacol., Biochem., Beh. 2009 Sept; 93 (3). 197-198. PMID:
19545585
29.
CREWS, F.T., BOETTIGER, C.A. Impulsivity, frontal lobes and risk for addiction,
Pharmacol., Biochem., Beh. 2009 Sept; 93 (3) 237-247. PMID: 19410598
30.
COLEMAN, J.R., JARSKOG, L.F., MOY, S.S., CREWS, F.T. Deficits in adult
prefrontal cortex neurons, and behavior following early post-natal NMDA antagonist
treatment, Pharmacol., Biochem., Beh. 2009 Sept; 93 (3) 322-330. PMID: 19409920
31.
HE, J., OVERSTREET, D.H., CREWS, F.T. Abstinence from moderate alcohol selfadministration alters progenitor cell proliferation and differentiation in multiple brain
regions of male and female P rats, Alcohol Clin Exp Res. 2009 Jan; 33(1):129-38. Epub
2008 Dec 10. PMID: 19076732
32.
CREWS, F.T., NIXON, K. Mechanisms of neurodegeneration and regeneration in
alcoholism, Alcohol Alcohol. 2009 Mar-Apr; 44(2):115-27. PMID: 18940959
33.
NIXON K, KIM D.H., POTTS E.N., HE J., CREWS, F.T. Distinct cell proliferation
events during abstinence after alcohol dependence: Microglia proliferation precedes
neurogenesis, Neurobiology of Disease, 2008 Aug; 31(2):218-29. Epub 2008 May 3.
PMID: 18585922.
34.
STEVENSON, J.R., SCHROEDER, J.P., NIXON, K., BESHEER, J., CREWS, F.T.,
HODGE, C.W. Abstinence following Alcohol Drinking Produces Depression-Like
Behavior and Reduced Hippocampal Neurogenesis in Mice,
Neuropsychopharmacology. 2009 Apr; 34(5):1209-22. Epub 2008 Jun 18. PMID:
18563059
35.
LIU, Y., QIN, L., WILSON, B., WU, X., QIAN, L., GRANHOLM, A.C., CREWS,
F.T., HONG, J.S. Endotoxin induces a delayed loss of TH-IR neurons in substantia
nigra and motor behavioral deficits, Neurotoxicology. 2008. Sep; 29(5):864-70. Epub
2008 Mar 13. PMID: 18471886
36.
QIN, L., HE, J., HANES, R.N., PLUZAREV, O., HONG, J., CREWS, F.T. Increased
systemic and brain cytokine production and neuroinflammation by endotoxin following
ethanol treatment, Journal of Neuroinflammation, Mar 18; 5:10, 2008 PMID:
18348728
37.
HE, J., CREWS, F.T. Increased MCP-1 and microglia in various regions of the human
alcoholic brain, Experimental Neurology 210(2): 349-58, 2008. PMID: 18190912
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38.
NICHOLAS, P.C., KIM, D., CREWS, F.T., MACDONALD, J.M.. 1H NMR-based
metabolomic analysis of liver, serum, and brain following ethanol administration in
rats, Chemical Research Toxicology, 21: 408-20, 2008. PMID: 18095657
39.
CREWS, F., HE, JUN, and HODGE, CLYDE. Adolescent cortical development: a
critical period of vulnerability for addiction, Pharmacology, Biochemistry and
Behavior, Special Issue, 86(2): 189-199, 2007. PMID: 17222895
40.
QIN, L., WU, X., BLOCK, M., LIU, Y. X., BREESE, G., HONG, J.S., KNAPP, D.,
CREWS, F.T. Systemic LPS Causes Chronic Neuroinflammation and Progressive
Neurodegeneration, GLIA 55: 453-462, 2007. PMID: 17203472
41.
HE, JUN, and CREWS, F.T. Neurogenesis decreases during brain maturation from
adolescence to adulthood. Pharmacology, Biochemistry and Behavior, Special Issue,
86(2): 327-333, 2007. PMID: 17169417
42.
CREWS, F.T., NIXON, KIM, KIM, DANIEL, JOSEPH, JAMES, SHUKITT-HALE,
BARBARA, QIN, LIYA, ZOU, JIAN. BHT blocks NF-B activation and EthanolInduced Brain Damage. Alcohol Clin Exp Res, 30(11): 1938-1949, 2006. PMID:
17067360
43.
NICOLAS, P., KIM, D., CREWS, F.T., MacDONALD, J. Proton NMR Spectroscopic
Determination of Ethanol-Induced Formation of Ethyl Glucuronide in Liver.
Analytical Biochemistry, 358: 185-191, 2006. PMID: 17027904
44.
ZOU, J. and CREWS, F.T. CREB and NFB transcription factors regulate
sensitivity to excitotoxic and oxidative stress induced neuronal cell death. Cellular and
Molecular Neurobiology, 1-21, 2006. PMID: 16633891
45.
CREWS, F.T., BECHARA, R., BROWN, L., GUIDOT, D., MANDREKAR, P.,
OAK, S., QIN, L., SZABO G., WHEELER, M., ZOU, J. Cytokines and Alcohol.
Alcohol Clin Exp Res, 30(4): 720-730, 2006. PMID: 16573591
46.
CREWS, F.T., MDZINARISHVILI A., HE, J., KIM, D., and NIXON, K.
Neurogenesis in adolescent brain is potently inhibited by ethanol. Neuroscience 137:
437-445, 2006. PMID: 16289890
47.
CREWS, F.T., BUCKLEY, T., DODD, P., ENDE, G., FOLEY, N., HARPER, C., HE,
J., INNES, D., LOH, E-W., PFEFFERBAUM, A., ZOU, J., AND SULLIVAN, E.
Alcoholic Neurobiology: Changes in Dependence and Recovery. Alcohol Clin Exp
Res, 29(8): 1504-1513, 2005. PMID: 16156047
48.
HE, J, NIXON, K., SHETTY, A., and CREWS, F.T. Chronic alcohol exposure
reduces hippocampal neurogenesis and dendritic growth of newborn neurons.
European Journal of Neuroscience, 21(10): 2711-2720, 2005. PMID: 15926919
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49.
MONTI PM, MIRANDA R JR, NIXON K, SHER KJ, SWARTZWELDER HS,
TAPERT SF, WHITE A, CREWS FT. Adolescence: booze, brains, and behavior.
Alcohol Clin Exp Res, 29(2): 207-20, 2005. PMID: 15714044
50.
PANDEY, S., CHARTOFF, E., CARLEZON, W., ZOU, J., ZHANG, H., KREIBICH,
A., BLENDY, J., AND CREWS, F.T. CREB Gene Transcription Factors: Role in
Molecular Mechanisms of Alcohol and Drug Addiction. Alcohol Clin Exp Res, 29(2):
176-184, 2005. PMID: 15714041
51.
ZOU, J.Y. and CREWS, F.T.: Tumor necrosis factor- potentiates glutamate
neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures. Brain
Research, 1034: 11-24, 2005. PMID: 15713255
52.
NIXON, K. and CREWS, F.T. Temporally Specific Burst in Cell Proliferation
Increases Hippocampal Neurogenesis in Protracted Abstinence from Alcohol. The
Journal of Neuroscience, 24(43): 9714-9722, 2004. PMID: 15509760
53.
KAMPOV-POLEVOY A.B., EICK C., BOLAND G., KHALITOV E., CREWS F.T.
Sweet liking, novelty seeking, and gender predict alcoholic status. Alcohol Clin Exp
Res, 28(9): 1291-1298, 2004. PMID: 15365298
54.
CREWS, F.T., NIXON, K. and WILKIE, MB. Exercise Reverses Ethanol Inhibition of
Adult Neurogenesis. Alcohol, 33(1): 63-71, 2004. PMID: 15353174
55.
CREWS, F.T., and NIXON, K. Alcohol, Neural Stem Cells, and Adult Neurogenesis.
Alcohol Research and Health, 27: 197-204, 2003. PMID: 15303631
56.
CREWS, F.T., COLLINS, M., DLUGOS, C., LITTLETON, J., NEAFSEY, E.J.,
PENTNEY, R., SNELL, L., TABAKOFF, B., ZOU, J., NORONHA, A., AND
WILKINS, L. Alcohol-Induced Neurodegeneration: When, Where and Why? Alcohol
Clin Exp Res, 28(2): 350-364, 2004. PMID: 15112943
57.
KAMPOV-POLEVOY, A.B., ZIEDONIS, D., STEINBERG, M.L., PINSKY, I.,
KREJCI, J., EICK, C., BOLAND, G., KHALITOV, E., CREWS, F.T.: Association
between sweet preference and paternal history of alcoholism in psychiatric and
substance abuse patients. Alchol Clin Exp Res, 27(12): 1929-1936, 2003. PMID:
14691380
58.
DUKA, T., GENTRY, J., MALCOLM, R., RIPLEY, T., BORLIKOVA, G.,
STEPHENS, D., VEATCH, L., BECKER, H., CREWS, F.T. Consequences of
multiple withdrawal from alcohol. Alcohol Clin Exp Res, 28(2): 233-246, 2004.
PMID: 15112931
59.
BISON, S. and CREWS, F.T.: Alcohol Withdrawal Increases Neuropeptide Y in Rat
Brain. Alchol Clin Exp Res, 27(7): 1173-1183, 2003. PMID: 12878925
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60.
CREWS, F. T. and BRAUN, C.J.: Binge ethanol treatment causes greater brain
damage in alcohol-preferring P rats than in alcohol nonpreferring NP rats. Alchol
Clin Exp Res, 27(7): 1075-1082, 2003. PMID: 12878913
61.
CREWS, F.T., MILLER, M.W., MA, W., NIXON, K., ZAWADA, W.M., AND
ZAKHARI, S.: Neural Stem Cells and Alcohol. Alcohol Clin Exp Res, 27(2): 324-335,
2003. PMID: 12605082
62.
NIXON, K. AND CREWS, F.T.: Binge ethanol exposure decreases neurogenesis in
adult rat hippocampus. Journal of Neurochem 83: 1087-1093, 2002. PMID: 12437579
63.
OBERNIER, J.A., WHITE, A.M., SWARTZWELDER H.S., and CREWS, F.T.:
Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats.
Pharmacol Biochem Behav 72:521-532, 2002. PMID: 12175448
64.
ISRAEL, J., CREWS, F.T., THURMAN, R.G., TU, GC, GARVER, B, PONNAPPA,
B, RUBIN, BR, HOPLIGHT, B, SETHNA, M, HANES, R, WILKIE, M.B and
WHEELER, MD. Gene and Antisense Delivery in Alcoholism Research. Alcohol Clin
Exp Res 26(4)582-585, 2002. PMID: 11981136
65.
OBERNIER, J.A., BOULDIN, T.W., and CREWS, F.T.: Binge ethanol exposure in
adult rats causes necrotic cell death. Alcohol Clin Exp Res 26(4): 547-557, 2002.
PMID: 11981132
66.
CREWS, FT.: Summary Report of a Symposium: Genes and Gene Delivery for
Diseases of Alcoholism. Alcohol Clin Exp Res 25(12):1778-1800, 2001. PMID:
11781512
67.
KNAPP, D.J., BRAUN C.J., QIAN Y., FERNANDES A., DUNCAN G.E., CREWS
F.T., and BREESE G.R.: Regional specificity of ethanol and NMDA action in brain
revealed with FOS-like immunohistochemistry and differential routes of drug
administration. Alcohol Clin Exp Res 25(11):1662-1672, 2001. PMID: 11707641
68.
PENLAND, S., HOPLIGHT, B., OBERNIER, J., and CREWS, F.T.: Effects of
nicotine on ethanol dependence and brain damage. Alcohol 24(1):45-54, 2001. PMID:
11524181
69.
WEST, S.L., GARBUTT, J.C., CAREY, T.S., LUX, L.J., JACKMAN, A.M.,
TOLLESTON-RINEHART, S., LOHR, K.N., and CREWS, F.T.: Pharmacotherapy
for alcohol dependence. Evidence Report No. 3 (Contract 290-97-0011) to Research
Triangle Institute, University of North Carolina, Chapel Hill. AHCP Republication No.
99-E004. Rockville, MD: Agency for Health Care Policy and Research, January 1999.
PMID: 11487800
70.
CREWS, F.T.: Neurotoxicity of alcohol: excitotoxicity, oxidative stress, neurotrophic
factors, apoptosis, and cell adhesion molecules. Chapter 5. In: Review of NIAAA’s
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Neuroscience and Behavioral Research Portfolio, (Eds.) A. Noronha, M. Eckardt, and
K. Warren. National Institute on Alcohol Abuse and Alcoholism Research, Monograph
No. 34, Bethesda, MD: the Institute, pp. 189-206, 2000.
71.
CREWS, F.T., DUPONT, R., GRANT, B., SPEAR, L., SWARTZWELDER, S.,
TAPERT, S., and WILSON, W.: Brain 101. In: A Parents’s Guide For The
Prevention Of Alcohol, Tobacco, And Other Drug Use. (Eds.) Georgetown Preparatory
School, 4-7, 2003.
72.
CREWS, F.T.: Effects of Alcohol Abuse on the Brain. In: Handbook of the Medical
Consequences of Alcohol and Drug Abuse, (Ed.) J. Brick, The Hayworth Press Inc., 85138, 2003.
73.
CREWS, F.T., RUDOLPH J.G., and CHANDLER, L.J.: Glutamate and AlcoholInduced Neurotoxicity. In: Glutamate and Addiction. (Eds.) B.H. Herman, J.
Frankenheim, R. Litten, P.H. Sheridan, F.F. Weight, and S.R. Zukin. Humana Press,
357-373, 2002.
74.
BOWDEN. S.C., CREWS, F.T., BATES, M.E., FALS-STEWART W., and
AMBROSE, M.L.: Neurotoxicity and neurocognitive impairments with alcohol and
drug-use disorders: potential roles in addiction and recovery. Alcohol Clin Exp Res
25(2):317-321, 2001. PMID: 11236849
75.
CREWS, F.T., BRAUN, C.J., ALI, R., KNAPP, D.J.: Interaction of nutrition and
binge ethanol treatment on brain damage and withdrawal. J Biomed Sci 8:134-142,
2001. PMID: 11173987
76.
CREWS, F.T., BRAUN, C.J., HOPLIGHT B., SWITZER, III, R.C., and KNAPP, D.J.:
Binge ethanol consumption causes differential brain damage in young-adolescent
compared to adult rats. Alcohol Clin Exp Res 24(11):1712-1723, 2000. PMID:
11104119
77.
RUDOLPH, J.G., LEMASTERS, J.J., and CREWS, F.T.: Effects of NMDA and
ferrous sulfate on oxidation and cell death in primary neuronal cultures. Neurochem
Int 37:497-507, 2000. PMID: 10871701
78.
CREWS, F.T.: Alcohol and Neurodegeneration. CNS Drug Reviews 5(4):379-394,
1999.
79.
AYYAGARI, P.V. and CREWS, F.T.: Inositol Lipids (Phosphatidylinositol) and
Neural Function. In: Elsevier’s Encyclopedia of Neuroscience, (Eds.) G. Adelman, and
B. Smith, Elsevier, Amsterdam, reprinted 2nd enlarged and revised edition, 1999.
80.
CREWS, F.T., WAAGE, H.G., WILKIE, M.B., and LAUDER, J.M.: Ethanol
pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by
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brain derived neurotrophic factor. Alcohol Clin Exp Res 23(11):1834-1842, 1999.
PMID: 10591601
81.
OVERSTREET, D.H., KAMPOV-POLEVY, A.B., REZVANI, A.H., BRAUN, C.,
BARTUS, R.T. and CREWS, F.T.: Suppression of alcohol intake by chronic naloxone
treatment in P rats: Tolerance development and elevation of opiate receptor binding.
Alcohol Clin Exp Res 23(11):1761-1771, 1999. PMID: 10591592
82.
KNAPP, D.J. and CREWS, F.T.: Induction of Cyclooxygenase-2 in brain during acute
and chronic ethanol treatment and ethanol withdrawal. Alcohol Clin Exp Res 23(4):
633-643, 1999. PMID: 10235299
83.
GARBUTT, J.C., WEST, S.L., CAREY, T.S., LOHR, KATHLEEN N., CREWS, F.T.:
Pharmacological treatment of alcohol dependence: A review of the evidence. JAMA
281:1318-1325, 1999. PMID: 10208148
84.
RUDOLPH, J.G., LEMASTERS, J.J. and CREWS, F.T.: Effects of chronic ethanol
exposure on oxidation and NMDA-stimulated neuronal death in primary cortical
neuronal cultures. Alcohol Clin Exp Res 22(9)2080-2085, 1998. PMID: 9884154
85.
CHANDLER, L.J., HARRIS, R.A. and CREWS, F.T. Ethanol tolerance and synaptic
plasticity. TiPS 19(12):491-495, 1998. PMID: 9871410
86.
DUNCAN, G.E., KNAPP, D.J., BREESE, G.R., CREWS, F.T. and Little K.Y.:
Species differences in regional patterns of 3H-8-OH-DPAT and 3H-Zolpidem binding in
the rat and human brain. Pharmacol Biochem Behav 60(2):439-448, 1998. PMID:
9632227
87.
CREWS, F.T., STECK, J.C., CHANDLER, L. J., RILL, M., YU C.J., and DAY, A.
Ethanol, Stroke, Brain Damage and Excitotoxicity. Pharmacol Biochem Behav
59(4):981-991, 1998. PMID: 9586859
88.
KNAPP, D.J., DUNCAN, G.E., CREWS, F.T. and BREESE, G.R.: Induction of foslike proteins and ultrasonic vocalizations during ethanol withdrawal: Further evidence
or withdrawal-induced anxiety. Alcohol Clin Exp Res 22(2)481-493, 1998. PMID:
9581657
89.
KNAPP, D.J., OVERSTREET, D.H., CREWS, F.T. Brain 5-HT1A receptor
autoradiography and hypothermic responses in rats bred for differences in 8-OH-DPAT
sensitivity. Brain Res 782(1-2):1-10, 1998. PMID: 9519243
90.
AYYAGARI, P.B., GERBER, M., JOSEPH, J.A., and CREWS, F.T.: Uncoupling of
muscarinic cholinergic phosphoinositide signals in senescent cerebral cortical and
hippocampal membranes. Neurochem Int 32(1):107-115, 1998. PMID: 9460709
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91.
RUDOLPH, J.G., WALKER, D.W., IIMURO, Y., THURMAN, R.G. and CREWS,
F.T.: NMDA receptor binding in adult rat brain after several chronic ethanol
treatment protocols. Alcohol Clin Exp Res 21(8):1508-1519, 1997. PMID: 9394125
92.
MCCOWN, T.J., KNAPP, D.J. and CREWS, F.T.: Inferior collicular seizure
generalization produces site-selective cortical induction of cyclooxygenase 2 (COX-2).
Brain Res 767(2):370--374, 1997. PMID: 9367271
93.
CHANDLER, L.J., SUTTON G, NORWOOD D, SUMNERS C. and CREWS, F.T.
Chronic ethanol increases NMDA-stimulated nitric oxide formation but not receptor
density in cultured cortical neurons. Mol Pharmacol 51(5):733-740, 1997. PMID:
9145911
94.
RUDOLPH, J.G., LEMASTERS, J.J. and CREWS, F.T.: Use of a multiwell
fluorescence scanner with propidium iodide to assess NMDA mediated excitotoxicity in
rat cortical neuronal cultures. Neurosci Lett 221(3):149-152, 1997. PMID: 9121686
95.
NARANG, N., AYYAGARI, P. V., GERBER, M., JOSEPH, J.A. and CREWS, F.T.
Age-related Loss of Cholinergic Muscarinic Coupling to PLC: Comparison with
Changes in Brain Regional PLC Subtypes mRNA Distribution. Brain Res 708:143-152,
1996. PMID: 8720870
96.
OVERSTREET, D.H., REZVANI, A.H., KNAPP, D.J., CREWS, F.T., and
JANOWSKY, D.S.: Further selection of rat lines differing in 5-HT-1A receptor
sensitivity: behavioral and functional correlates. Psychiatr Genet 6(3):107-117, 1996.
PMID: 8902886
97.
CREWS, F. T., MORROW, L., CRISWELL, H. and BREESE, G. Effects of Ethanol
on Ion Channels. International Review of Neurobiology. In: International Review of
Neurobiology (Eds. Ronald J. Bradley, R. Adron Harris and Peter Jenner), Academic
Press, International Review of Neurobiology 39:283-367, 1996. PMID: 8894851
98.
HARTMANN, H., ECKERT, A., CREWS, F.T. and MüLLER, W.E. -amyloid
amplifies PLC activity and Ca2+ signalling in fully differentiated brain cells of adult
mice. Amyloid Int J Exp Clin Invest 3:234-241, 1996.
99.
AYYAGARI, P.V. and CREWS, F.T. Inositol Lipids (Phosphatidylinositol) and
Neural Function. In: Encyclopedia of Neuroscience, (Eds.) G. Adelman, and B. Smith,
Elsevier, Amsterdam (2d Edition), 1996.
100.
NARANG, N., and CREWS, F.T., Age does not alter Protein Kinase C Isozymes
mRNA Expression in Rat Brain. Neurochem Res 20: 1119-1126, 1995. PMID: 8746795
101.
CHANDLER, L. J., KOPNISKY, K., RICHARDS, E., CREWS, F. T., and
SUMNERS, C.: Angiotensin II decreases inducible nitric oxide synthase expression in
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rat astroglial cultures. Am J Physiol 268 (Cell Physiol 37):C700-C707, 1995. PMID:
7534984
102.
CHANDLER, L. J., GUZMAN, N., SUMNERS, C., and CREWS, F.T.: Induction of
nitric oxide synthase in brain glial cells: Possible interaction with ethanol in reactive
neuronal injury. In: Alcohol and Glial Cells. (Ed.: Lancaster, Francine E.), NIAAA
Monograph No. 27:195-214, 1994.
103.
CHANDLER, L. J., GUZMAN, N. J., SUMNERS, C., and CREWS, F. T.: Magnesium
and zinc potentiate ethanol inhibition of NMDA stimulated nitric oxide synthase in
cortical neurons. J Pharmacol Exp Ther 271:67-75, 1994. PMID: 7525932
104.
CREWS, F. T., KURIAN, P., and FREUND, G.: Cholinergic and serotonergic
stimulation of phosphoinositide hydrolysis is decreased in Alzheimer's disease. Life Sci
55:1993-2002, 1994. PMID: 7997058
105.
CREWS, F. T.: Amyloid ß protein disruption of cholinergic and growth factor
phospholipase C signals could underlie cognitive and neurodegenerative aspects of
Alzheimer's Disease. Neurobiology of Aging, 15(Suppl. 2):S95-96, 1994. PMID:
7700473
106.
KOZIKOWSKI, A.P., OGNYANOV, V.I. KURIAN, P., AND CREWS, F.T.:
Synthesis and binding studies of an optically pure Hexadeoxy-1,4,5Tris(Methylenesulfonic acid) analogue of IP3. Tetrahedron Letters 34(2):219-222,
1993.
107.
PURUSHOTHAM, K.R., NAKAGAWA, Y., KURIAN, P., PATEL, R., CREWS, F.T.,
and HUMPHREYS-BEHER, M.G.: Activation of Phosphatidylinositol 3-kinase and
Phosphatidylinositol 4-kinase During Rat Parotid Acinar Cell Proliferation. Biochim
Biophys Acta 1178:40-48, 1993. PMID: 8392376
108.
PATEL, R.A., HUTT-FLETCHER, L.M., and CREWS, F.T.: Epstein-Barr Virus
Infectivity of Raji and Molt 4 Cells: Differences in Plasma Membrane Lipids and
Apparent Microviscosity. Virology 195:121-131, 1993. PMID: 8391180
109.
PATEL, R. A., KURIAN, P., RAIZADA, M. K., and CREWS, F. T.: Insulin
Stimulates Phosphatidylinositol-3 Kinase Activity in Rat Neuronal Primary Cultures.
Neurochem 61: 360-363, 1993. PMID: 8390565
110.
DAVDA, R.K., CHANDLER, L.J., CREWS, F.T., and GUZMAN, N.J.: Ethanol
Enhances the Endothelial Nitric Oxide Synthase Response to Agonists. Hypertension
21:939-943, 1993. PMID: 7685006
111.
KURIAN, P., NARANG, N., CHANDLER, L.J., and CREWS, F.T.: Radio-label and
Mass Determinations of Inositol 1,3,4,5-Tetrakisphosphate Formation in Rat Cerebral
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Cortical Slices:Differential Effects of Myo-Inositol. Neurochem Res 18:639-645, 1993.
PMID: 8474581
112.
CHANDLER, L.J., NEWSOME, H., SUMNERS, C. and CREWS, F.T.: Chronic
Ethanol Exposure Potentiates NMDA Excitotoxicity in Cerebral Cortical Neurons. J.
Neurochem. 60:1578-1581, 1993. PMID: 8455043
113.
CHANDLER, L.J., SUMNERS, C., and CREWS, F.T.: Ethanol Inhibits NMDA
Receptor Mediated Excitotoxicity in Rat Primary Neuronal Cultures. Alcohol Clin Exp
Res 17:54-60, 1993. PMID: 8383926
114.
CREWS, F.T., NEWSOME, H., GERBER, M., SUMNERS, C., CHANDLER, L.J.,
and FREUND, G.: Molecular Mechanisms of Alcohol Neurotoxicity. In: Alcohol, Cell
Membranes, and Signal Transduction in Brain. (Eds: C. Alling and G. Sun), Plenum
Press, Lund, Sweden, pp. 123-138, 1993.
115.
CREWS, F.T. and CHANDLER, L.J.: Excitotoxicity and the Neuropathology of
Ethanol. In: Alcohol-induced Brain Damage. (Eds.: Hunt, W. A.and n, S. J.), NIAAA
Monograph No. 22:355-371, 1993.
116.
CREWS, F.T., KURIAN, P., and FREUND, G.: Neurodegeneration in Alzheimer's
Disease May Be Caused by b-Amyloid Protein Inhibition of Growth Factor and
Neurotransmitter Activation of Phosphoinositide Hydrolysis. Alzheimer's Disease:
Advances in Clinical and Basic Research. (Eds.: B. Corain, K. Iqbal, M. Nicolini, B.
Winblad, H. Wisniewski and P. Zatta), John Wiley & Sons Ltd., Baffins Lane,
Chichester, West Sussex PO19 1UD, England, pp. 307-314, 1993.
117.
CREWS, F.T., KURIAN, P., CHANDLER, L.J., and PONTZER, N.J.: Actions and
Interactions of Cholinergic and Excitatory Amino Acid Receptors on Phosphoinositide
Signals, Excitotoxicity, and Neuroplasticity. Phospholipids and Signal Transduction,
(Eds.: Massarelli, R., Horrocks, L., Kanfer, J.N. and Loffelholz, K.), Springer-Verlag
GmbH, Heidelberg, Germany, 1993, pp. 115-121.
118.
GUZMAN, N.J. and CREWS, F.T.: Regulation of myo-Inositol Transport by Glucose
and Protein Kinase C in Glomerular Mesangial Cells. Kidney Int 42:33-40, 1992.
119.
PATEL, R. and CREWS, F.T.: Membrane Lipids and Dynamics in the Enveloped
Virus Life Cycle. Advances in Membrane Fluidity. Membrane Interactions of HIV:
Implications for Pathogenesis and Therapy in AIDS. (Eds.: Roland C. Aloia and Cyril
C. Curtain), Wiley-Liss, Inc., 605 Third Avenue, New York, NY 10158-0012, 6: 237253. 1992.
120.
KURIAN, P., CHANDLER, L.J., GERBER, M., McKINNEY, M., MILLER, J.H., and
CREWS, F.T.: Unique Aspects of Muscarinic Receptor Stimulated Inositol
Polyphosphate Formation in Brain: Changes in Senescence. In: Treatment of
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Dementias. (Eds.: E.M. Meyer, J.W. Simpkins, and F.T. Crews), Plenum Press, New
York. 40:377-386, 1992.
121.
CREWS, F. T., POTTER, M. R., and CHANDER, R.: Phosphatidylserine Stimulation
of Macrophage Protein Secretion: Potential Healing and Trophic Mechanisms. In:
Treatment of Dementias. (Eds.: E.M. Meyer, J.W. Simpkins, and F.T. Crews), Plenum
Press, New York. 40:187-198, 1992.
122.
KOZIKOWSKI, A.P., FAUQ, A.H., POWIS, G., KURIAN, P., and CREWS, F.T.:
Expedient Synthetic Routes to [3H]-D-3-Azido-3-deoxy-myo-inositol and D-3-Azido-3deoxy-myo-inositol 2,4,5-Trisphosphate. J Chem Soc Chem Commun 4: 362-364,
1992.
123.
PONTZER, N.J., MADAMBA, S., SIGGINS, G.R., and CREWS, F.T.:
Concentrations of Carbachol Stimulating Phosphoinositide Hydrolysis Cause a
Sustained Decrease in Membrane Potential and Firing Rate: Role of Inositol and
Inositol Polyphosphate Second Messengers. Brain Res 597:189-199, 1992. PMID:
1335346
124.
GYURKO, R., KIMURA, B., KURIAN, P., CREWS, F.T., and PHILLIPS, M.I.:
Angiotensin II Receptor Subtypes play Opposite Roles in Regulating
Phosphatidylinositol Hyrdolysis in Rat Skin Slices. Biochem Biophys Res Comm
186:285-292, 1992. PMID: 1632771
125.
GUZMAN, NJ, CREWS FT, Regulation of inositol transport by glucose and protein
kinase C in mesangial cells, Kidney Int. 1992 Jul;42(1):33-40 PMID: 1635353
126.
KURIAN, P., NARANG, N., and CREWS, F.T.: Decreased Carbachol Stimulated
Inositol 1,3,4,5-tetrakisphosphate Formation in Senescent Rat Cerebral Cortical Slices.
Neurobiol of Aging. 13:521-526, 1992. PMID: 1508302
127.
CREWS, F.T., McELHANEY, R., FREUND, G., BALLINGER, JR., W.E., and
RAIZADA, M.: Insulin-like Growth Factor 1 Receptor Binding in Brains of
Alzheimer's and Alcoholic Patients. J Neurochem 58:1205-1210, 1992. PMID:
1312569
128.
KURIAN, P., CHANDLER, L.J., PATEL, R., and CREWS, F.T.: Receptor Coupling
To Phosphoinositide Signals. Neurobiology of Essential Fatty Acids: Advances in
Experimental Medicine and Biology. Vol. 18 (Eds.: N.G. Bazan, Mary G. Murphy and
Gino Toffano), Plenum Press, New York, pp. 399-411, 1992. PMID: 1322027
129.
CREWS, F.T., POTTER, M.R., and CHANDER, R.: Phosphatidylserine Stimulation
of Macrophage Protein Secretion: Potential Healing and Trophic Mechanisms. In: The
Treatment of Dementias: A New Generation of Progress. (Eds: E.M. Meyer, J.W.
Simpkins and F.T. Crews), Plenum Press, New York. 1991.
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130.
GUZMAN, N.J., KURIAN, P., ANDALORO, V.J., CREWS, F.T., and TISHER, C.C.:
Effects of Glucose on Receptor-Mediated Phosphoinositide Hydrolysis and Second
Messenger Generation in Rat Glomerular Mesangial Cells. J Am Soc Nephrol 2:179190, 1991. PMID: 1659461
131.
RAULLI, R.E. and CREWS, F.T.: Differences in Imidazoline and Phenylethylamine
Alpha-Adrenergic Agonists: Comparison of Binding Affinity and Phosphoinositide
Response. Neuropharm 30:745-751, 1991. PMID: 1656308
132.
GONZALES, R.A. and CREWS, F.T.: Chronic Ethanol Inhibits Receptor-Stimulated
Phosphoinositide Hydrolysis in Rat Liver Slices. Alcohol 8:131-136, 1991. PMID:
1648364
133.
CHANDLER, L.J., KURIAN, P., and CREWS, F.T.: Effects of Ethanol on Inositol
1,3,4,5-Tetrakisphosphate Metabolism by Rat Brain Homogenates. Alcohol Clin Exp
Res 15:136-140, 1991. PMID: 2024726
134.
CREWS, F.T., McELHANEY, R., FREUND, G., BALLINGER, W.E., WALKER,
D.W., HUNTER, B.E., and RAIZADA, M.K.: Binding of [125-I]-Insulin-like Growth
Factor-1 (IGF-1) in Brains of Alzheimer's and Alcoholic Patients. In: Molecular
Biology and Physiology of Insulin and Insulin-like Growth Factors. (Eds: M.K.
Raizada and D. LeRoith), Plenum Press,New York: 483-492, 1991. PMID: 1662868
135.
CREWS, F.T.: Pharmacologic Manipulation of Neuronal Damage. In: New Issues in
Neurosciences: Basic and Clinical Approaches. (Ed. S. Frost), John Wiley and Sons,
Chichester, England. 2:139-149, 1990.
136.
CREWS, F.T. and SALAZAR, A.: Mechanisms Underlying Neuronal Degeneration.
In: New Issues in Neurosciences: Basic and Clinical Approaches. (Ed. S. Frost), John
Wiley and Sons, Chichester, England. 2: 135-138, 1990.
137.
CREWS, F.T., NARANG, N., KURIAN, P., and CHANDLER, L.J.: Effects of
inositol concentration on carbachol stimulated [3H] inositol 1,3,4,5 tetrakisphosphate
formation. European J. Pharmacol. 183:759-761, 1990.
138.
PUIG, J.F., PACITTI, A.J., GUZMAN, N.J., CREWS, F.T., SUMNERS, C., and
RAIZADA, M.K.: Alpha1-Adrenergic Receptors in the Brain: Characterization in
Glial Cultures and Comparison with Neuronal Cultures. Brain Research. 527: 318-325,
1990. PMID: 1979238
139.
CHANDLER, L.J. and CREWS, F.T.: Calcium-Versus G Protein-Mediated
Phosphoinositide Hydrolysis in Rat Cerebral Cortical Synaptoneurosomes. J.
Neurochem. 55:1022-1030, 1990. PMID: 2166771
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140.
BORST, S.E., NARANG, N., CREWS, F.T., and SCARPACE, P.J.: Reduced Alpha1Adrenergic Receptor-Mediated Inositide Hydrolysis in Cardiac Atria of Senescent Rats.
J. Cardiovascular Pharm. 16:444-448, 1990. PMID: 1700216
141.
PONTZER, N.J. and CREWS, F.T.: Desensitization of Muscarinic Stimulated
Hippocampal Cell Firing is Related to PI Hydrolysis and Inhibited by Lithium. J.
Pharmacol. Exp. Therap. 253: 921-929, 1990. PMID: 2162952
142.
NARANG, N., GARG, L.C., and CREWS, F.T.: Adenosine and Its Analogs Stimulate
Phosphoinositide Hydrolysis in the Kidney. Pharmacology. 40:90-95,1990. PMID:
2161113
143.
PONTZER, N.J., CHANDLER, L.J., STEVENS, B.R., and CREWS, F.T.: Receptors,
Phosphoinositol Hydrolysis and Plasticity of Nerve Cells. Progress in Brain Research.
86:221-225, 1990. PMID: 1708153
144.
CREWS, F.T., PONTZER, N.J., and CHANDLER, L.J.: Muscarinic Receptors,
Phosphoinositide Hydrolysis, and Neuronal Plasticity in the Hippocampus. Novel
Approaches to the Treatment of Alzheimer's Disease. Plenum Press, N.Y., pp. 17-24,
1989.
145.
CREWS, F.T., PONTZER, N.J., and CHANDLER, L.J.: Effects of Ethanol on
Receptors Coupled to Phosphoinositide Hydrolysis in Brain. Molecular Mechanisms of
Alcohol. (Ed: G.Y. Sun et al.), Humana Press, Clifton, N.J., pp. 39-55, 1989.
146.
GONZALES, R.A., CHANDLER, L.J., and CREWS, F.T.: Ethanol Interactions with
Phosphoinositide linked Signal Transduction. Biochemistry and Physiology of
Substance Abuse, (Ed.: Ronald R. Watson, Ph.D.), CRC Press, Boca Raton, Florida,
1:37-47, 1989.
147.
PONTZER, N.J. and CREWS, F.T.: Inositol Lipids (Phosphatidylinositol) and Neural
Function. Neuroscience. (Ed.:George Adelman Birkhauser), Boston, Mass. pp. 81-83,
1989.
148.
PONTZER, N.J., CREWS, F.T., and GONZALES, R.A.: Ethanol and Muscarinic
Signal Transduction in the Brain. In: Phospholipids in the Nervous System:
Biochemical and Molecular Pathology. Fidia Research Series, (Eds.: Bazan, N.G.,
Horrocks, L.A. and Toffano, G.), 17:195-204, 1989.
149.
RAULLI, RE., ARENDASH, G., CREWS, FT., Effects of nBM lesions on muscarinicstimulation of phosphoinositide hydrolysis, Neurobiol Aging, 1989 Mar-Apr;
10(2):191-7, PMID 2542819
150.
CHANDLER, L.J. and CREWS, F.T.: Calcium Stimulated versus G-Protein mediated
Phosphoinositide Hydrolysis in Brain, Neurochemical Aspects of Phospholipid
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Metabolism. (Eds.: L. Freysz, J.N. Hawthorne, G. Toffano) Liviana Press, Padova,
Italy. 20:135-140, 1989. PMID: 2560898
151.
McARDLE, S., GARG, L.C., and CREWS, F.T.: Cholinergic receptors in renal
medullary collecting duct cells. J. Pharmacol. Exp. Therap. 248:12-16, 1989. PMID:
2536424
152.
CHANDLER, L.J. and CREWS, F.T.: Effects of Ethanol on Phosphoinositide
Hydrolysis in Brain. Proceeding of Fourth ISBRA Congress. In: Biomedical and Social
Aspects of Alcohol and Alcoholism, (Eds.: K. Kuriyama, A. Takada, H. Ishii), pp. 225228, Elsevier Science Publishers, Kyoto, Japan, 1988.
153.
CREWS, F.T., CHANDLER, L.J., CALDERINI, G., and MEYER, E.M.: Changes in
Membrane and Calcium Mediated Signals in Senescence. In:
Psychoneuroendocrinology of Aging: Basic and Clinical Aspects, (Ed. G. Valenti), pp.
7-15, Fidia Research Series, Parma, Italy, 1988.
154.
CREWS, F.T., McELHANEY, M.R., KLEPNER, C.A., and LIPPA, A.S.: Lipids are
Major Components of Human Immunodeficiency Virus (HIV): Modification of HIV
Lipid Composition, Membrane Organization, and Protein Conformation by AL-721.
Drug Develop. Res. 14:31-44, 1988.
155.
CREWS, F.T., RAULLI, R., SCOTT, J., SUMNERS, C., and RAIZADA, M.K.:
Adrenergic Stimulation of Phosphoinositide Hydrolysis: Drug Potency, Efficacy, and
Sensitivity Changes. Progress in Catecholamine Research, (Eds.: M. Sandler, A.
Dahlstrom and R.H. Belmaker), pp. 383-387, Alan R. Liss, Inc., 1988.
156.
SUMNERS, C., RUETH, SM., MYERS, LM., KALBERG, CJ., CREWS, FT,
RAIZADA, MK., Phorbol ester-induced upregulation of angiotensin II receptors in
neuronal cultures is potentiated by a calcium ionophore, J. Neurchem. 1988
Jul;51(1):153-62. PMID 3132530
157.
GONZALES, R.A. and CREWS, F.T.: Differential Regulation of Phosphoinositide
Phosphodiesterase Activity in Brain Membranes by Guanine Nucleotides and Calcium.
J. Neurochem. 50:1522-1528, 1988. PMID: 2834515
158.
GONZALES, R.A. and CREWS, F.T.: Effects of Ethanol In-vivo and In-vitro on
Stimulated Phosphoinositide Hydrolysis in Rat Cortex and Cerebellum. Alcohol
Clinical and Exp. Res. 12:94-98, 1988. PMID: 2831752
159.
McARDLE, S., GARG, L.C., and CREWS, F.T.: Cholinergic Stimulation of
Phosphoinositide Hydrolysis in Rabbit Kidney. J. Pharmacol. Exp. Therap. 244:586591, 1988. PMID: 2831346
160.
BOTTIGLIERI, D.F., MORSE, C.A., CREWS, F.T., SUMNERS, C., and RAIZADA,
M.K.: Increased Expression of 1- adrenergic Receptors in the Hypothalamus of
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Spontaneously Hypertensive Rat Brain. Brain Res. 439:187-194, 1988. PMID:
2833983
161.
RAIZADA, M.K., MORSE, C.A., GONZALES, R.A., CREWS, F.T., and SUMNERS,
C.: Receptors for Phorbol Esters are Primarily Localized in Neurons: Comparison of
Neuronal and Glial Cultures. Neurochem. Res. 13:51-56, 1988. PMID: 3368029
162.
CREWS, F.T., GONZALES, R.A., RAULLI, R., McELHANEY, R., PONTZER, N.
and RAIZADA, M.K.: Interaction of Calcium with Receptor-Stimulated
Phosphoinositide Hydrolysis in Brain and Liver. Annals New York Acad. Sci. 522:8895, 1988. PMID: 2837125
163.
CREWS, F.T., RAULLI, R., GONZALES, R., SUMNERS, C., and RAIZADA, M.:
a1-adrenergic Receptor Stimulated Responses. J. Cardiovascular Pharm. II
(Suppl.1):S99-S106, 1988. PMID: 2459524
164.
GONZALES, R.A., GREGER, P.H., BAKER, S.P., GANZ, N.I,, BOLDEN, C.,
RAIZADA, M.K. and CREWS, F.T.: PhorbolEsters Inhibit Agonist-stimulated
Phosphoinositide Hydrolysis in Neuronal Primary Cultures. Developmental Brain Res.
37:59-66, 1987. PMID: 2894235
165.
GONZALES, R.A., CREWS, F.T., SUMNERS, C., and RAIZADA, M.K.:
Norepinephrine Regulation of Alpha1 Receptors and Alpha1-stimulated
Phosphoinositide Hydrolysis in Primary Neuronal Cultures. J. Pharmacol. Exp.
Therap. 242:764-771, 1987. PMID: 2821226
166.
GONZALES, R.A., GANZ, N., and CREWS, F.T.: Variations in Membrane
Sensitivity of Brain Region Synaptosomes to the Effects of Ethanol In-vitro and
Chronic In-vivo Treatment. J. Neurochem. 49:158-162, 1987. PMID: 3585327
167.
RAIZADA, M.K., PHILLIPS, M.I., CREWS, F.T., and SUMNERS, C.: Distinct
Angiotensin II Receptor in Primary Cultures of Glial Cells from Rat Brain. Proc. Natl.
Acad. Sci. USA. 84:4655-4659, 1987. PMID: 3474621
168.
SUMNERS, C., RUETH, S.M., CREWS, F.T., and RAIZADA, M.K.: Protein Kinase
C Agonists Increase the Expression of Angiotensin II Receptors in Neuronal Cultures.
J. Neurochem., 48:1954-1961, 1987. PMID: 3572405
169.
GONZALES, R.A. and CREWS, F.T.: Ethanol Effects on Receptor Activated Lipid
Hydrolysis in Brain and Liver. Alcohol and Alcoholism. Pergamon Journals Ltd.
(Suppl. 1): pp. 567-571, 1987. PMID: 2827697
170.
RAULLI, R. and CREWS, F.T.: The Role of Lipids in the Transduction of Signals
Mediated by Membrane Receptors. Rassegna. 8:142-150, 1986.
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171.
CREWS, F.T., MEYER, E.M., GONZALES, R.A., THEISS, C., OTERO, D.H.,
LARSEN, K., RAULLI, R., and CALDERINI, G.: Presynaptic and Postsynaptic
Approaches to Enhancing Central Cholinergic Neurotransmission. In: Treatment
Development Strategies for Alzheimer's Disease., (Eds.: T. Crook, R. Bartus, S. Ferris,
and S. Gershon), Mark Powley Publishing, Madison, Conn., pp. 385-419, 1986.
172.
CREWS, F.T., THEISS, C., RAULLI, R., and GONZALES, R.A.: The Effects of
Ethanol on Receptor Activated Phospholipid Cascades. In: Phospholipid Research and
the Nervous System: Vol. 4, Biochemical and Molecular Pharmacology, (Eds.: L.A.
Horrocks, L. Freysz and G. Toffano), pp. 121-132, 1986.
173.
SCOTT, J.A. and CREWS, F.T.: Down-regulation of Serotonin2, but not of Betaadrenergic Receptors during Chronic Treatment with Amitriptyline is Independent of
Stimulation of Serotonin2 and Beta-adrenergic Receptors. Neuropharmacology.
25:1301-1306, 1986. PMID: 3031528
174.
MEYER, E.M., CREWS, F.T., OTERO, D.H., and LARSEN, K.: Aging Decreases the
Sensitivity of Rat Cortical Synaptosomes to Calcium Ionophore Induced-Acetylcholine
Release. J. Neurochem. 47:1244-1246, 1986. PMID: 3091766
175.
GONZALES, R.A. and CREWS, F.T.: Correlation of Ethanol's Membrane Actions
and Inhibition of Receptor-stimulated Histamine Release from Rat Mast Cells. J.
Pharm. Exp. Ther. 239:111-116, 1986. PMID: 2428970
176.
FELDSTEIN, J.B., GONZALES, R.A., BAKER, S.P., SUMNERS, C., CREWS, F.T.,
and RAIZADA, M.K.: Decreased a1 Adrenergic Receptor Mediated Inositide
Hydrolysis in Neurons from Hypertensive Rat Brain. Am. J. Physiol. (Cell Physiol., 20)
251:C230-237, 1986. PMID: 2874741
177.
GONZALES, R.A., THEISS, C., and CREWS, F.T.: Effects of Ethanol on Stimulated
Inositol Phospholipid Hydrolysis in Rat Brain. J. Pharmacol. Exp. Ther. 237:92-98,
1986. PMID: 3007745
178.
CREWS, F.T., GONZALES, R.A., PALOVCIK, R., PHILLIPS, M.I., THEISS, C., and
RAIZADA, M.K.: Changes in Receptor Stimulated Phosphoinositide Hydrolysis in
Brain During Ethanol Administration, Aging and Other Pathological Conditions.
Psychopharmacology Bulletin. 22:775-780, 1986. PMID: 3025909
179.
CREWS, F.T.: Phospholipid Methylation and Membrane Function. In: Phospholipids
and Cellular Regulation, Vol. 1, (Ed.: J.F.Kuo), pp.131-158, CRC Press, Boca Raton,
Florida, 1985.
180.
CREWS, F.T. and HEIMAN, A.S.: Interaction of Phospholipid Methylation and
Phosphatidylinositol Metabolism in Stimulation of Secretion. In: Phospholipids in the
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Nervous System, Vol. 2. Physiological Roles, (Eds.: L. Horrocks et al.), pp. 87-98,
Raven Press, New York, 1985.
181.
GONZALES, R.A. and CREWS, F.T.: Guanine Nucleotides Stimulate Production of
Inositol Trisphosphate in Rat Cortical Membranes. Biochem. J. 232:799-804, 1985.
PMID: 3004420
182.
SARIN, P.S., GALLO, R.C., SCHEER, D.I., CREWS, F.T., and LIPPA, A.S.: Effects
of a Novel Compound (AL721) on HTLV-III Infectivity In-Vitro. New Engl. J. Med.
313:1289-1290, 1985. PMID: 2414659
183.
GONZALES, R.A., FELDSTEIN, J.B., CREWS, F.T., and RAIZADA, M.K.:
Receptor-Mediated Inositide Hydrolysis is a Neuronal Response: Comparison of
Primary Neuronal and Glial Cultures. Brain Research. 345:350-355, 1985. PMID:
2994846
184.
GONZALES, R.A. and CREWS, F.T.: Cholinergic- and Adrenergic-Stimulated
Inositide Hydrolysis in Brain: Interaction, Regional Distribution, and Coupling
Mechanisms. J. Neurochem. 45:1076-1084, 1985. PMID: 4031879
185.
HEIMAN, A.S. and CREWS, F.T.: Hydrocortisone Inhibits Phorbol Ester Stimulated
Release of Histamine and Arachidonic Acid from Rat Mast Cells. Biochem. Biophys.
Research Comm. 130:640-645, 1985. PMID: 2411263
186.
SCOTT, J.A. and CREWS, F.T.: Increase in Serotonin2 Receptor Density in Rat
Cerebral Cortex Slices by Stimulation of Beta-adrenergic Receptors. Biochem. Pharm.
34:1585-1588, 1985. PMID: 2986651
187.
GONZALES, R.A. and CREWS, F.T.: Effect of Ethanol and Aging on Histamine
Release and Membranes of Mast Cells. Alcohol. 2:313-316, 1985. PMID: 4015852
188.
HEIMAN, A.S. and CREWS, F.T.: Characterization of the Effects of Phorbol Esters
on Rat Mast Cell Secretion. J. Immun. 134:548-555, 1985. PMID: 2578054
189.
CREWS, F.T.: Phospholipid Methylation in Brain and Other Tissues. In: Methods in
Neurobiology: Vol. 1, Brain Neuro-transmitters and Neuromodulator Receptor
Methodologies, (Eds.: P.J. Marangos, I.C. Campbell and R.M. Cohen), pp. 217-226,
Academic Press, London, U.K., 1984.
190.
GONZALES, R.A. and CREWS, F.T.: Characterization of the Cholinergic Stimulation
of Phosphoinositide Hydrolysis in Rat Brain Slices. J. Neurosci. 4:3120-3127, 1984.
PMID: 6094748
191.
HEIMAN, A.S. and CREWS, F.T.: Inhibition of Immunoglobulin, but Not
Polypeptide Base-Stimulated Release of Histamine and Arachidonic Acid by AntiInflammatory Steroids. J. Pharmacol. Exp. Ther. 230:175-182, 1984. PMID: 6205135
Curriculum Vitae
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192.
HEIMAN, A.S. and CREWS, F.T.: Hydrocortisone Selectively Inhibits IgE-dependent
Arachidonic Acid Release from Rat Peritoneal Mast Cells. Prostaglandins. 27:335-343,
1984. PMID: 6201957
193.
MEYER, E.M., ST. ONGE, E., and CREWS, F.T.: Effects of Aging on Rat Cortical
Presynaptic Cholinergic Processes. Neurobiol. of Aging. 5:315-317, 1984. PMID:
6099468
194.
BONETTI, A.C., BATTISTELLA, A., CALDERINI, G., TEOLATO, S., CREWS,
F.T., GAITI, A., and TOFFANO, G.: Biochemical Alterations in the Mechanisms of
Synaptic Transmission in Aging Brain. In: Aging of the Brain, Vol. 22: (Eds.: D.
Samuel et al.), pp.171-181, Raven Press, New York, N.Y., 1983.
195.
CREWS, F.T., SCOTT, J.A., and SHORSTEIN, N.H.: Rapid Down-Regulation of
Serotonin2 Receptor Binding During Combined Administration of Tricyclic
Antidepressant Drugs and a-2 Antagonists. Neuropharmacology. 22:1203-1209, 1983.
PMID: 6139768
196.
MEHTA, J., MEHTA, P., OSTROWSKI, N., and CREWS, F.T.: Effects of Verapamil
on Platelet Aggregation, ATP Release and Thromboxane Generation. Thrombosis
Research. 30:469-475, 1983. PMID: 6612680
197.
CALDERINI, G., BONETTI, A.C., BATTISTELLA, A., CREWS, F.T. and
TOFFANO, G.: Biochemical Changes of Rat Brain Membranes with Aging.
Neurochemical Research. 8: 483-492, 1983. PMID: 6310426
198.
SCOTT, J.A. and CREWS, F.T.: Rapid Decrease in Rat Brain Beta Adrenergic
Receptor Binding During Combined Antidepressant Alpha-2 Antagonist Treatment. J.
Pharmacol. Exp. Ther. 224:640-646, 1983. PMID: 6131122
199.
CREWS, F.T., CAMACHO, A., and PHILLIPS, M.I.: Cholinergic Stimulation of
Hippocampal Pyramidal Cells is Inhibited by Increasing Membrane Cholesterol. Brain
Research. 261:155-158, 1983. PMID: 6301623.
200.
CREWS, F.T., MAJCHROWICZ, E., and MEEKS, R.: Changes in Cortical
Synaptosomal Plasma Membrane Fluidity and Composition in Ethanol-dependent Rats.
Psychopharmacology. 81:208-213, 1983. PMID: 6417708
201.
MEHTA, P., MEHTA, J., CREWS, F.T., ROY, L., OSTROWSKI, N., and
HORALEK, C.: Comparison of Umbilical Vein Models for Measurement of Relative
Prostacyclin and Thromboxane Production.Prostaglandins. 24:743-749, 1982.
202.
AXELROD, J., HIRATA, F., CREWS, F.T., ISHIZAKA, T., ISHIZAKA, K.,
McGIVNEY, A., and SIRAGANIAN, R.P.: Lipids and the Receptor Mediated Release
Curriculum Vitae
Fulton T. Crews
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of Histamine. In: Advances in Pharmacology and Therapeutics II, Vol. 2:
Neurotransmitters receptors, (Eds.: H. Yoshida, Y. Hagihara, and S. Ebashi), pp. 5767, Pergamon Press, New York, N.Y., 1982.
203.
HIRATA, F., CREWS, F.T., AXELROD, J., McGIVNEY, A., SIRAGANIAN, R.L.,
ISHIZAKA, T. and ISHIZAKA, K.: Biochemical Mechanism of Histamine Release
from Rat Mast Cells and Basophilic Leukemia Cells. In: Advances in the Biosciences,
Vol. 33: Advances in Histamine Research, (Eds.: B. Uvnas, and K. Tasaka), pp. 43-45,
Pergamon Press, N.Y., 1982.
204.
SIRAGANIAN, R.P., McGIVNEY, A., CREWS, F.T., HIRATA, F., and AXELROD,
J.: Rat Basophilic Leukemia Cell Lines Defective in Phospholipid Methyltransferase
Enzymes: Reconstitution by Hybridization of IgE-mediated Ca2+ Influx, Phospholipid
Methylation and Histamine Release. In: Biochemistry of S-Adenosylmethionine and
Related Compounds, (Eds.: E. Usdin, R.T. Borchardt, and C.R. Creveling), pp. 199202, Macmillan Press Ltd., London, 1982.
205.
TOFFANO, G., CALDERINI, G., BATTISTELLA, A., SCAPAGNINI, U., GAITI, A.,
PONZIO, F., ALGERI, S., and CREWS, F.T.: Biochemical changes related to neurotransmission in the aging brain. In: Aging, Vol. 18: Neural Aging and Its Implications
in Human Neurological Pathology, (Eds.: R.D. Terry, C.L. Bolis and G. Toffano), pp.
119-128, Raven Press, New York, N.Y., 1982.
206.
CREWS, F.T., CAMACHO, A., PHILLIPS, I., TJEENK WILLINK, E.C.,
CALDERINI, G., HIRATA, F., AXELROD, J., McGIVNEY, A., and SIRAGANIAN,
R.: Effects of membrane fluidity on mast cell and nerve cell function. In:
Phospholipids in the Nervous System, Vol. 1: Metabolism, pp. 21-35, Raven Press, New
York, N.Y., 1982.
207.
CREWS, F.T.: Effects of Membrane Fluidity on Secretion and Receptor Stimulation.
Psychopharmacology Bulletin 18:135-143, 1982. PMID: 6130559
208.
CREWS, F.T.: Rapid changes in phospholipid metabolism during secretion and
receptor activation. Int. Rev. Neurobiol. 23:141-163, 1982. PMID: 6288606
209.
SIRAGANIAN, R.P., McGIVNEY, A., BARSUMIAN, E.L., CREWS, F.T., HIRATA,
F., and AXELROD, J.: Variants of the rat basophilic leukemia cell line for the study of
histamine release. Federation Proc. 41:30-34, 1982. PMID: 6173265
210.
CALDERINI, G., ALDINIO, C., CREWS, F.T., GAITI, A., SCAPAGNINI, U.,
ALGERI, S., PONZIO, F., and TOFFANO, G.: Aging and information processing. In:
Apomorphine and Other Dopaminomimenics, Vol. 2: Clinical Pharmacology, (Eds.:
G.U. Corsini and G.L. Gessa), pp. 235-242, Raven Press, New York, N.Y., 1981.
Curriculum Vitae
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211.
CREWS, F.T., CALDERINI, G., BATTISTELLA, A., and TOFFANO, G.: Age
dependent changes in the methylation of rat brain phospholipids. Brain Res. 229:256259, 1981. PMID: 6272934
212.
McGIVNEY, A.L., MORITA, Y., CREWS, F.T., HIRATA, F., AXELROD, J., and
SIRAGANIAN, R. P.: Phospholipase activation in the IgE-mediated and Ca2+
ionophore A23187-induced release of histamine from rat basophilic leukemia cells.
Arch. Biochem. Biophys. 212:572-580, 1981. PMID: 6173019
213.
CREWS, F.T., MORITA, Y., McGIVNEY, A., HIRATA, F., SIRAGANIAN, R.P.,
and AXELROD, J.: IgE-mediated histamine release in rat basophilic leukemia cells:
receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic
acid. Arch. Biochem. Biophys. 212:561-571, 1981. PMID: 6173018
214.
McGIVNEY, A., CREWS, F.T., HIRATA, F., AXELROD, J., and SIRAGANIAN,
R.P.: Rat basophilic leukemia cell lines defective in phospholipid methyltransferase
enzymes, Ca2+ influx, and histamine release: Reconstitution by hybridization. Proc.
Natl. Acad. Sci. 78:6176-6180, 1981. PMID: 6171812
215.
CREWS, F.T., PAUL, S.M., and GOODWIN, F.K.: Acceleration of b-receptor
desensitization in combined administration of antidepressants and phenoxybenzamine.
Nature 290:787-789, 1981. PMID: 6261156
216.
CREWS, F.T. and SMITH, C.B.: The effects of antidepressants on the retention and
metabolism of [3H]-norepinephrine in rat brain slices. Neuropharmacology 20:363369, 1981. PMID: 7290350
217.
CREWS, F.T. and SMITH, C.B. Potentiation of responses to adrenergic nerve
stimulation in isolated rat atria during chronic tricyclic antidepressant administration. J.
Pharmacol. Exp. Ther. 215:143-149, 1980. PMID: 6256516
218.
CREWS, F.T., HIRATA, F., and AXELROD, J. Phospholipid methyltransferase
asymmetry in synaptosomal membranes. Neurochem. Res. 5:983-991, 1980. PMID:
7207699
219.
CREWS, F.T., HIRATA, F., and AXELROD, J.: Identification and properties of
methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J.
Neurochem. 34:1491-1498, 1980. PMID: 7381471
220.
PAUL, S.M. and CREWS, F.T. Rapid desensitization of cerebral cortical b-adrenergic
receptors induced by desmethylimipramine and phenoxybenzamine. Eur. J. Pharmacol.
62:349-350, 1980. PMID: 6245899
221.
CREWS, F.T., MORITA, Y., HIRATA, F., AXELROD, J., and SIRAGANIAN, R.P.:
Phospholipid methylation affects immunoglobulin E-mediated histamine and
Curriculum Vitae
Fulton T. Crews
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arachidonic acid release in rat leukemic basophils. Biochem. Biophys. Res. Commun.
93:42-49, 1980. PMID: 6155125
222.
HIRATA, F., AXELROD, J., and CREWS, F.T.: Concanavalin A stimulates
phospholipid methylation and phosphatidylserine decarboxylation in rat mast cells.
Proc. Natl. Acad. Sci. USA. 76:4813-4816, 1979. PMID: 92021.
223.
CREWS, F.T. and SMITH, C.B.: Presynaptic alpha-receptor subsensitivity after longterm antidepressant treatment. Science 202:322-324, 1978. PMID: 211589
BOOKS EDITED/JOURNAL GUEST EDITOR
“Brain, Behavior, and Immunity” Guest Editor, Crews, F.T., July, 2011
“Adolescent, Drug Abuse and Mental Disorders,” Pharmacology Biochemistry and
Behavior, Guest Editor, Crews, F., Duka, T., Vol. 86, Issue 2, Elsevier Press, February
2007.
“Impulsivity and Frontal Lobes: Roles in Psychopathology and Addiction,”
Pharmacology Biochemistry and Behavior, Guest Editor, Duka, T., Crews, F., Vol. 93,
Number 3, ISSN 0091-3057, Elsevier Press, September 2009.
"Treatment of Dementias: A New Generation of Progress." Ed. by E. M. Meyer, J. W.
Simpkins, J. Yamamoto, and F. T. Crews. Advances in Behavioral Biology, Vol. 40,
Plenum Press, N.Y., 1992.
TELECONFERENCES:
1.
Scripted & Moderated: "Gold Symposium: Genetics &
Alcohol Abuse" University of Florida, April 25, 1990
Faculty Drs. Begleiter, Crabbe and Crews
2.
Scripted & Moderated: "Medical Issues in Geriatrics:
Parkinsonism & Related Neuro-Degenerative Diseases"
University of Florida, March 14, 1990
Faculty Drs. Appel, Kopin, Greer and Crews
3.
"Alcohol & Medication Abuse in the Elderly."
GRECC, University of Florida, February 28, 1990
Dr. G. Caranasos coordinator
4.
Scripted & Moderated: "Fetal Alcohol Syndrome"
University of Florida, February 14, 1990
Faculty Drs. Weiner, Bordman, Key and Crews
5.
Scripted & Moderated "New Discoveries in Alzheimers’
Curriculum Vitae
Fulton T. Crews
Page 40
Revised 1/7/2014
Disease" University of Maryland, September 27, 1989
Faculty Drs. Davies, Pettigrew, Price, DeLeon and Crews
GRANTS
1.
MOLECULAR AND CELLULAR ALCOHOL RESEARCH TRAINING
PI: F.T. Crews.
National Institute of Alcohol Abuse and Alcoholism
T32-AA07573-17
4/1/13 - 3/31/18 - Institutional National Research Service Award
TDC: $544,218
2.
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOL
PI: F.T. Crews
National Institute of Alcohol Abuse and Alcoholism
P50-AA11605-17
12/1/12 - 11/30/17
TDC: $6,773,605
3.
Adult Neurobiology following adolescent drinking
PI: Ryan Vetreno
Sponsor: F.T. Crews
NIH/NIAAA
F32-AA021040-02
8/1//12 – 7/31/14
$52,190
4.
UNC-CH NADIA Underage Drinking and Adult Brain Morphology in Rats
PI: F.T. Crews
NIH/NIAAA
U01 (AA020023-03)
9/1/10 – 8/31/15
TDC: 245,597
5.
UNC-CH NADIA Administrative Core
PI: F.T. Crews
NIH/NIAAA
U01 (AA020024-03)
9/1/10 – 8/31/15
TD: $292,657
6.
UNC-CH NADIA Scientific Core
PI: F.T. Crews
NIH/NIAAA
U01 (AA020022-03)
9/1/10 – 8/31/15
Curriculum Vitae
Fulton T. Crews
Page 41
Revised 1/7/2014
TD: 298,948
7.
MECHANISMS OF ALCOHOLIC PATHOLOGY: A COLLABORATIVE
PARTNERSHIP BETWEEN NCCU & UNC
PI: F.T. Crews
Alcohol Abuse and Alcoholism
U54 (AA019767-03)
8/1/10-7/31/15
TDC: $94,050
8.
MOLECULAR AND CELLULAR ALCOHOL RESEARCH TRAINING
PI: F.T. Crews.
National Institute of Alcohol Abuse and Alcoholism
T32-AA07573-01
4/1/97 - 3/31/13 - Institutional National Research Service Award
TDC: $544,218
9.
MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOL
PI: F.T. Crews
National Institute of Alcohol Abuse and Alcoholism
P50-AA11605-01
12/1/97 - 11/30/12
TDC: $5,653,548
10.
ETHANOL EFFECTS ON NEUROTRANSMISSION
PI: F.T. Crews
National Institute of Alcohol Abuse and Alcoholism
R37-AA06069
01/03/84 - 6/30/2009 **Merit Award**
TDC: $1,265,150
11.
EVIDENCE REPORT ON THE PHARMACOTHERAPY OF ALCOHOL
DEPENDENCE (Contract)
PI: Gordon DeFriese
Agency for Health Care Policy and Research
Contract #290-97-0001
TDC: $79,600
12.
CATECHOLAMINE/ANGIOTENSIN II INTERACTIONS IN THE BRAIN.
PI: Colin Sumners
Co-PI: F.T. Crews
National Institutes of Health
NS-19441
04/01/83-06/99. *Javitts Award*
TDC: $150,285/yr
Curriculum Vitae
Fulton T. Crews
Page 42
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13.
NORTH CAROLINA DEPARTMENT OF CORRECTION
(Contract)
PI: F. T. Crews
1/1/98 – 5/30/98
TDC: $60,000
14.
EFFECTS OF SUBSTANCE ABUSE (YOUTH EDUCATIONAL WEBSITE)
PI: F.T. Crews
Park Foundation
1/1/97 - 12/31/97
TDC: $10,000
15.
SUBSTANCE ABUSE EDUCATION WEBSITE
PI: F.T. Crews
University of North Carolina at Chapel Hill
1/1/97 - 6/30/97
TDC: $29,839
16.
EQUIPMENT RECRUITMENT GRANT
North Carolina Biotechnology Center
1/1/95-12/31/96
TDC: $250,000
17.
DISCOVERY OF NOVEL DRUGS FOR ALZHEIMER'S DISEASE
PI: James W. Simpkins
Co-P.I.: F.T. Crews
National Institute on Aging.
1 P01 AG10485-01
10/91 - 09/96
TDC: $167,211/yr. {Fulton T. Crews component}
18.
STIMULATED PHOSPHOINOSITIDE TURNOVER IN AGING BRAIN
PI: F.T. Crews
National Institutes of Health
AG06660
9/30/87 - 8/31/90
TDC: $234,000
19.
PRECLINICAL PHOSPHOLIPID ANTI-AIDS DRUGS
PI: F.T. Crews
National Institutes of Health, National Cooperative Drug Discovery Group
A125690,
12/1/87 - 11/30/90
TDC: $210,000/yr.
20.
AGING AND HIPPOCAMPAL RESPONSES
Curriculum Vitae
Fulton T. Crews
Page 43
Revised 1/7/2014
PI: F.T. Crews
Alzheimer’s Disease and Related Disorders Association
86-056,
7/86 - 7/87
TDC: $20,000
21.
EFFECTS OF CHANGES IN VIRAL LIPIDS ON INFECTIVITY OF HIV
PI: F.T. Crews
The American Foundation for AIDS Research
8/87 - 7/89
TDC: $100,000/yr.
22.
CHANGES IN CELLULAR RESPONSES TO DRUGS AND OTHER AGENTS
DURING AGING
PI: F.T. Crews
Geriatric Research Education and Clinical Centers
5/1/84 - 4/31/85
TDC: $50,000
23.
INTERACTION OF ACETYLCHOLINE, PEPTIDE NEUROTRANSMITTERS
AND MEMBRANE PROPERTIES DURING AGING
PI: F.T. Crews
American Federation for Aging
7/83 - 6/84
TDC: $15,000
24.
COMPARISONS OF CHANGES IN AGING HUMAN AND RAT MAST CELLS
INDUCED BY ETHANOL
PI: F.T. Crews
National Institute on Alcohol Abuse and Alcoholism
9/82 - 8/85
TDC: $190,021/yr.
25.
AGE DEPENDENT CHANGES IN MEMBRANE FLUIDITY
PI: F.T. Crews
National Institute on Aging
9/82 - 8/83
TDC: $15,000
26.
MOLECULAR MECHANISMS OF SECRETION
National Science Foundation
9/81 - 8/84
TDC: $214,500
University of North Carolina at Chapel Hill Mini Medical School Lecture Series:
Curriculum Vitae
Fulton T. Crews
Page 44
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March 1998, “Pleasure and reward systems in the brain and the causes of addiction”,
Chapel Hill, NC
April 1996, “Alcoholism and Drug Abuse: No One Believes It’s Just a Question of
Willpower Anymore”, Chapel Hill, NC
INVITED LECTURESHIPS (2009)
1. Stanley Marsh III Endowed Lectureship, University of Texas. 6/16-17/09
2. Salzburg Plenary Lectureship, Austrian Neuroscience Association, Salzburg 9/18/09
3. Okey Memorial Lecture: Psychiatry Research Trust, London England 11/17/09
INVITED LECTURESHIPS (2008)
1. Plenary Speaker USA-Japan Workshop on Alcoholism, NIAAA Invitee, Yokohama,
Japan, 2008
INVITED LECTURESHIPS (2007)
1. Distinguished Investigator Award for Scientific Excellence, Research `Society on
Alcoholism, Chicago, Illinois
2. Seventh Annual Guze Symposium on Alcoholism. “Neurobiology of Addiction and
Recovery: Is Adolescence a Risk Period?” Washington University, St.Louis, Missouri.
February 2007,
INVITED LECTURESHIPS (2006)
1. Grass Lectureship Award, US Society for Neuroscience grant to University of Alaska
Fairbanks,2006
2. Bowles Lectureship Award, CAS, University of North Carolina at Chapel Hill,2006
3. Mark Keller Honorary Lecturer, National Institutes of Health Clinical Center, 2006
4. Brown University. “Brain Degeneration and Regeneration during Addiction and
Recovery: Does neurobiology drive behavioral change? Providence, RI. August 2006,
INVITED LECTURESHIPS (2005)
1. May 2005, The University of Puerto Rico School of Medicine RISE Program, San Juan,
Puerto Rico
2. June 2005, Pavlov State Medical University, St. Petersburg, Russia
INVITED LECTURESHIPS (2004)
1. February 2004, University of Arkansas for Medical Sciences. “Neurodegeneration and
Regeneration in Alcoholism and Recovery”. Little Rock, Arkansas.
2. April 2004, University of South Florida. “Neurodegeneration and Regeneration in Adult
Brain: What can we learn from Alcoholism?” Tampa, Florida.
3. October 2004, Pathology Grand Rounds Speaker, "Neurodegeneration and Regeneration in
the adult brain, what can we learn alcoholism?" UNC Chapel Hill, NC
Curriculum Vitae
Fulton T. Crews
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4.
Revised 1/7/2014
October 2004, Society for Neuroscience Satellite Symposium Speaker, “Changes in brain
structure and behavior during withdrawal/abstinence from alcohol dependence” San Diego,
CA
INVITED LECTURESHIPS (2003)
1. January 2003, Medical University of South Carolina. NIAAA Director’s Meeting.
Presented on the Bowles Center For Alcohol Studies. Charleston, SC.
2. January 2003, Winter Conference on Brain Research. Panel chair: “What controls
neurogenesis?” with Dr. Jim Joseph, Dr. Steve Goldberg, and Dr. Rao Mahendra.
Snowshoe, Utah.
3. February 2003, NIDA Stem Cell Meeting, “Ethanol disrupts adult and adolescent neural
stem cell proliferation and neurogenesis,” Gaithersburg, MD.
4. February 2003, Chicago Chapter of Neurosciences Meeting. Grass Lecturer, “Alcoholism
and Recovery: Do Neurodegeneration and Regeneration Contribute?’ In Symposium A,
“Alcohol and Drug addiction: underlying molecular and cellular mechanisms,” Chicago,
IL.
5. February 2003, Chicago Chapter of Neurosciences Meeting. Brain Bee speaker, “Exercise,
alcohol and other factors that change my brain,” Chicago, IL.
6. April 2003, ACNP. Keynote speaker, “Addiction and the Brain”, Southern Pines, NC.
INVITED LECTURESHIPS (2002)
1. January 2002, University of Connecticut, Farmington, Connecticut
2. February 2002, University of Colorado Health Sciences Center, Denver, Colorado
3. March 2002, Grand Rounds speaker NIH, Alcohol Awareness Month, Bethesda, Maryland
4. March 2002, BIRCWH Seminar, Chapel Hill, North Carolina
5. June 2002, RSA Symposia Session 5: Neuronal stem cells and alcohol, San Francisco,
California
6. July 2002, RSA Satellite Symposium: Neurobiological Mechanisms of Adolescent Alcohol
Abuse: New Findings, New Directions, San Francisco, California
7. August 2002, Institute of Psychiatry: Alcohol Dependence: Neurodegeneration and
regeneration in addiction and recovery, Vienna, Austria
8. September 2002, GSK Center for Excellence for Drug Discovery: 2nd International
Symposium: Mechanisms of Cell Death in Neurodegenerative Diseases, Perguia, Italy
9. October 2002, NC Outer Banks Conference: Changes in Brain During Addiction and
Recovery
10. October 2002, Medical University of South Carolina, Department of Pharmacology
Seminar: “Alcohol Dependence and Recovery: Do neurodegeneration and regeneration
contribute?” Charleston, South Carolina.
11. November 2002, Society for Neurosciences Annual Meeting. Abstract presentation:
“Ethanol inhibits neurogenesis in adolescent rats.” Presented with Alexander
Mdzinarishvili and Kimberly Nixon, Orlando, Florida.
12. December 2002, American College of Neuropsychopharmacology, 41st Annual Meeting.
Abstract presentation: Adolescent ethanol exposure inhibits neurogenesis. San Juan, Puerto
Rico
INVITED LECTURESHIPS (2001)
Curriculum Vitae
Fulton T. Crews
Page 46
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1. June 2001, Research Society on Alcoholism Meeting Symposium speaker Montreal,
Canada
2. July 2001, British Pharmacology Society Meeting Symposium speaker the University
College Dublin, Dublin, Ireland
3. July 2001, platform speaker 1st Alaska Summer Neuroscience Conference, Fairbanks,
Alaska
4. September 2001, Guest Speaker Medical University of South Carolina, Charleston
Alcohol Research Center
5. December 2001, American College of Neuropsychopharmacology Meeting Symposium
speaker, Waikoloa, Hawaii
INVITED LECTURESHIPS (2000)
1. February 2000, Guest Speaker at the Medical College of Virginia, Richmond, Virginia
2. July 2000, Guest Speaker at Satellite Symposium Recent Advancement in Biomedical
Research, Taiwan
3. September 2000, Guest Speaker at 2nd Annual Carolina Conference on Addiction,
Charlotte, North Carolina
INVITED LECTURESHIPS (1999)
1. March 1999, Guest Speaker at the Charles University, Prague, Czech Republic
2. April 1999, Guest Speaker at the University of Texas at Austin, Austin, Texas
3. April 1999, Guest Speaker at the University of Texas Health Science Center, San Antonio,
Texas
4. May 1999, Guest Speaker at the Universita Degli Studi Di Firenze, Florence, Italy
5. October 1999, Guest Speaker at the Carolina Conference on Addiction, Winston-Salem,
North Carolina
INVITED LECTURESHIPS (1998)
1. March 1998, Guest Speaker at the Scripps Clinic Conference, La Jolla, CA.
2. November 1998, Guest Speaker at the Applications of Gene Knockout Techniques to
Alcohol Research Symposium, Los Angeles, CA.
3. November 1998, Guest Speaker at London UMDS, London, England.
INVITED LECTURESHIPS (1996)
1. January 1996, Symposium speaker: “Muscarinic receptor coupling to calcium signaling:
Relationship to trophic activity,” Winter Conference on Brain Research, Snowmass,
Colorado
2. October 1996, Invite to participate in the Symposium “US/Russian Biomedical and
Behavioral Research Collaboration in Alcohol Abuse and Alcoholism,” and gave a lecture,
Moscow, Russia.
INVITED LECTURESHIPS (1995)
1. June 1995, Symposium speaker: “Ethanol, Excitotoxicity and Stroke Induced Brain
Damage,” Research Society on Alcoholism, Steamboat Springs, Colorado
Curriculum Vitae
Fulton T. Crews
Page 47
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INVITED LECTURESHIPS (1994)
1. January 1994, Symposium speaker: "Growth factor responses to stroke", Winter Conference
on Brain Research, Snowbird, Utah
2. February 1994, Seminar speaker: "Molecular mechanisms of alcohol induced brain
damage", Univ. of N.C., Chapel Hill, North Carolina
3. April 1994, Seminar speaker: "Effects of ethanol on excitotoxicity", Texas Tech,
Lubbock, Texas
4. April 1994, Seminar speaker: "Molecular mechanisms of alcohol induced brain damage",
Bowman Gray School of Medicine, Wake-Forest, North Carolina
5. July 1994, Seminar speaker: "Changes in excitatory amino acid receptors following stroke
and chronic ethanol administration: potential interactions", Synthelabo Reserche, Paris,
France
6. September 1994, Seminar speaker: "Changes in phosphoinositide signalling during aging
and Alzheimer's Disease". SEPS Mtg., Age-related Disorders: Pharmacology and Etiology,
Clearwater Beach, FL
INVITED LECTURESHIPS (1993)
1. January 1993, Symposium speaker: "Cholinergic receptors and neurotransmission," Winter
Conference on Brain Research, Whistler, BC, Canada
2. March 1993, Symposium speaker: "Excitotoxicity," South-East Nerve Net,
Cedar Key, FL
3.
4.
5.
6.
7.
June 1993, Symposium speaker: "Ethanol and ionotropic glutamate receptors," Research
Society on Alcoholism, San Antonio, Texas
July 1993, Symposium speaker: "Growth factor and neurotransmitter activation of
phosphoinositide metabolism", World Congress of Gerontology, Budapest, Hungary
September 1993, Symposium speaker: "Muscarinic-cholinergic activation of phospholipase
C: Changes in aging and Alzheimer's Disease," (Novel treatments of age-related brain
disorders), Central Institute of Mental Health, University of Heidelberg, Germany.
November 1993, Symposium speaker: "Change in Signal Transduction during neuronal
aging", Neurobiology of Aging: From Classic Hypotheses to New Directions, Airlie
Conference Center, Warrenton, Virginia.
November 1993, Seminar speaker: "Changes in phosphoinositide signaling during aging and
Alzheimer's Disease", Department of Pharmacology & Therapeutics, University of South
Florida, Tampa, Florida.
INVITED LECTURESHIPS (1992)
1. June 1992, "Induction of nitric oxide synthase in astroglial cultures", Research Society on
Alcoholism Meeting, La Jolla, CA
2. June 1992, Symposium Speaker: "Alcohol, Cell Membranes and Signal Transduction in
Brain"; ISBRA Satellite Meeting, Lund, Sweden
3. July 1992, Lecture: Neurodegeneration during Aging and Alcohol Abuse. Central Institute
Mental Health, Univ. of Heidelberg, Mannheim, Germany
4. July 1992, Symposium Speaker: "Growth factor and Neurotransmitter activation of
phosphoinositide metabolism and intracellular calcium regulation: Relevance to Alzheimer's
Curriculum Vitae
Fulton T. Crews
Page 48
5.
6.
7.
8.
9.
Revised 1/7/2014
Disease". Third International Conference on Alzheimer's Disease and Related Disorders,
Padova, Italy
July 1992, Lecture: "Phosphatidylserine stimulation of macrophage protein secretion:
Potential healing and trophic mechanisms:" FIDIA Research Laboratories, AbanoTerme,
Italy
September 1992, Psychiatry Lecture: "Decreased phosphoinositide signals in Alzheimer's
brain: Inhibition by b-Amyloid may underlie Alzheimer's neurodegeneration," SUNY at
Stony Brook Health Sciences Center, Stony Brook, New York
October 1992, Lecture: "ß-amyloid and phosphoinositide signals in Alzheimer's Disease",
Lilly Research Laboratories, Indianapolis, Indiana
October 1992, Symposium Speaker: "Molecular mechanisms of brain damage in
alcoholism," Society for Neuroscience, Anaheim, CA
December 1992, "Decreased Phosphoinositide Signals in Alzheimer's Disease: Inhibition by
Amyloid-b Protein May Underlie Alzheimer's Neurodegeneration," American College of
Neuropsychopharmacology, San Juan, Puerto Rico