PRODUCT CATALOG CYTOKINES GROWTH FACTORS CHEMOKINES ANTIBODIES INTERLEUKINS PROTEIN BUNDLES 2014 1 S H E N A N D OA H B I O T E C H N O LO GY began in April of 2006. Our home office and lab are conveniently located in Warwick, Pennsylvania, near Philadelphia. Our vision is to provide a superior source of recombinant cytokines for research applications to the academic and industrial world. Our owners are dedicated scientists, just like you, who work in our lab. We understand your science and can directly communicate with you. Shenandoah is a privately-held company that is designated as a Certified Woman Business Enterprise by the state of Pennsylvania. At Shenandoah, we specialize in the manufacturing of recombinant proteins from E.coli. Our current product line is mainly focused on cytokines, chemokines, and growth factors typically used in a wide variety of research applications. We are dedicated to helping you with all areas of your research including cancer, stem cell biology, immunology, developmental biology, and many others. We also offer a line of polyclonal and monoclonal antibodies that complement the use of our proteins. In addition to the products in our catalog, we provide services that are comprised of: inclusion body protein folding and purification, custom protein expression, and bulk (milligrams to grams) protein production of most products. We are your “One-Stop Protein Shop”! For inquiring minds that are curious to know where our name came from, it is quite an interesting story. One of our owners became involved in animal rescue in 2002 and this is how our story begins. They were rescuing Maine Coons (a breed of cat) from the area around Shenandoah Mountain, in upstate New York, on the Appalachian Trail. There was one particular 10-day-old, fire engine red kitten, who stole their heart. She had a bad eye infection but it was love at first sight and she was named Shenandoah (affectionately shortened to Doah Doah). The kitten turned into an incredible, beautiful cat that loved life and having fun. In honor of this cat, Shenandoah, comes our name, Shenandoah Biotechnology. To continue to honor Doah Doah, our company also donates one dollar per order to the Hurricane Pets Rescue (HPR). This is a nationwide, no-kill, non-profit rescue that provides shelter and care for the animals that become homeless because of a hurricane. For more information, here is their website: http://www.hurricanepetsrescue.org/ If you are ever in the Philadelphia area, please call us for a tour of our facility. You can meet our rescue cats that help run the office! 2 Promotional Offer Shenandoah’s Sample Policy Nitty Gritty Details: - Credit is applied to a larger size of the same product as the mini purchased and is only for the amount paid for the original mini purchase (applicable if the mini was purchased at a discounted rate). - Mini credit is NOT automatic and our sample policy must be referenced at the time of purchase (via the website this can be done in the notes section of your cart, over the phone when placing a phone order or in text via email). - Larger size must be purchased within 3 months of the mini purchase. - One trial credit valid per product. - This policy can be discontinued at any time. - Credits are only available for purchases made direct from Shenandoah. MADE IN THE USA www.shenandoah-bt.com 3 NOW ! E L B A L I AVA ANIMAL FREE CYTOKINES SHENANDOAH’S PREMIER PROTEINS Shenandoah is proud to announce our new Animal Free Protein products. These products are produced using Animal Free raw components and processes, in a non-mammalian system, to produce the highest quality recombinant proteins. Animal Free proteins are ideal for researchers concerned about the ever-present risk of contaminating viruses, prions and trace growth factors from FBS and animal-derived ingredients typically used in standard recombinant protein production techniques. Shenandoah takes the necessary steps to ensure that Shenandoah’s Animal Free Proteins are produced under stringent protocols, with strict standards, and documented accordingly. Shenandoah’s Animal Free Production Process: - NO FBS or Animal-Derived Ingredients - Non-mammalian production system (E.coli-based system) - Animal Free facility, fermentor, columns, filters, labware, lyophilization and storage Shenandoah’s Animal Free Quality Standards (*product-specific exceptions are noted when applicable): - Endotoxin levels are <1.0 EU per ug protein (included on lot-specific COA) - Purity levels are 95% or greater (included on lot-specific COA) - Bioactivity is comparable to recombinant protein produced in traditional techniques (included on lot-specific COA if/when available) Shenandoah’s Animal Free Documentation: - Certificate of Analysis - included with each product - Certificate of Origin - available upon request - Additional Documentation - available upon request - Amino acid analysis - Protein concentration determination - Lot-specific SDS-PAGE - Lot-specific endotoxin via LAL analysis - Lot-specific bioactivity (if available) Shenandoah’s Animal Free Proteins Common Uses: - Stem cell cultures - Serum free growth media supplementation - Cell therapy studies - Other ex vivo pre-clinical research These products are for RESEARCH PURPOSES ONLY and are not FDA approved for any uses in humans. MADE IN THE USA • www.shenandoah-bt.com 4 ANIMAL FREE PROTEINS Catalog Name Catalog # Product Name Mini ug Price Std. ug Price Value ug Price Mg Price Activin-A (AF) 100-43AF Human Activin A (AF) 2 65 10 165 100 535 1 5,280 CD-40-Ligand (AF)100-25AF Human CD40 Ligand (AF) 10 65 50 165 NA NA 1 1,320 EGF (AF) Human Epidermal Growth Factor (AF) 100 65 500 165 NA NA 1 240 FGF-basic 147 (AF)100-28AF 100-26AF Human Fibroblast Growth Factor 147 basic (AF) 10 65 50 165 NA NA 1 1,320 FGF-basic-154 (AF)100-146AF Human Fibroblast Growth Factor 154 basic (AF) 10 65 50 165 NA NA 1 1,100 FLT-3-Ligand (AF) 100-21AF Human Flt-3 Ligand (AF) 2 65 10 165 100 415 1 3,960 GM-CSF (AF) 100-08AF Human Granulocyte Macrophage Colony Stimulating Factor (AF) 5 65 20 165 100 415 1 3,080 IGF-I (AF) 100-34AF Human Insulin-like Growth Factor I (AF) 20 65 100 165 NA NA 1 275 IL-1-β (AF) 100-167AF Human Interleukin-1-beta (AF) 2 65 10 165 100 415 1 3,960 IL-2 (AF) 100-12AF Human Interleukin-2 (AF) 10 65 50 165 NA NA 1 715 IL-3 (AF) 100-80AF Human Interleukin-3 (AF) 2 65 10 165 100 415 1 2,970 IL-4 (AF) 100-09AF Human Interleukin-4 (AF) 5 65 20 165 100 415 1 3,960 IL-6 (AF) 100-10AF Human Interleukin-6 (AF) 5 65 20 165 100 415 1 2,970 IL-21 (AF) 100-90AF Human Interleukin-21 (AF) 2 65 10 165 100 535 1 5,280 Human Epstein-Barr Virus Induced Gene 3 (AF) 5 65 20 165 100 535 1 5,280 IL-27 / IL-35 (EBI3) (AF) 100-162AF LIF (AF) 100-47AF Human Leukemia Inhibitory Factor (AF) 5 65 25 165 100 415 1 2,750 NGF-β (AF) 100-38AF Human Nerve Growth Factor-beta (AF) 5 65 20 165 100 415 1 2,970 PDGF-AA (AF) 100-16AF Human Platelet Derived Growth Factor-AA (AF) 2 65 10 165 100 415 1 3,850 PDGF-AB (AF) 100-17AF Human Platelet Derived Growth Factor-AB (AF) 2 65 10 165 100 415 1 3,850 PDGF-BB (AF) 100-18AF Human Platelet Derived Growth Factor-BB (AF) 2 65 10 165 100 415 1 3,850 SCF (AF) 100-04AF Human Stem Cell Factor (AF) 2 65 10 165 100 415 1 2,860 TPO (AF) 100-05AF Human Thrombopoietin (AF) 2 65 10 165 100 535 1 4,400 TGF-β-3 (AF) 100-109AF Human Transforming Growth Factor beta-3 (AF) 2 65 10 165 100 645 1 6,380 TNF-α (AF) Human Tumor Necrosis Factor alpha (AF) 10 65 50 165 NA NA 1 1,320 VEGF-121 (AF) 100-116AF 100-111AF Human Vascular Endothelial Growth Factor-121 (AF) 2 65 10 165 100 415 1 3,960 VEGF-165 (AF) 100-44AF Human Vascular Endothelial Growth Factor-165 (AF) 2 65 10 165 100 415 1 3,960 Activin A (AF) 200-29AF Mouse Activin A (AF) 2 65 10 165 100 535 1 5,280 GDNF (AF) 200-37AF Mouse Glial Derived Neurotrophic Factor (AF) 2 65 10 165 100 535 1 5,280 IL-3 (AF) 200-01AF Mouse Interleukin-3 (AF) 2 65 10 165 100 535 1 4,400 IL-4 (AF) 200-18AF Mouse Interleukin-4 (AF) 2 65 10 165 100 415 1 3,740 IL-11(AF) 200-64AF Mouse Interleukin-11 (AF) 2 65 10 165 100 535 1 5,280 IL-33 (AF) 200-36AF Mouse Interleukin-33 (AF) 2 65 10 165 100 535 1 5,280 LIF (AF) 200-33AF Mouse Leukemia Inhibitory Factor (AF) 5 65 20 165 100 535 1 5,280 Activin A (AF) 300-06AF Rat Activin A (AF) 2 65 10 165 100 535 1 5,280 FGF-basic (AF) 300-02AF Rat Fibroblast Growth Factor-basic (AF) 10 65 50 165 NA NA 1 1,320 GDNF (AF) 300-10AF Rat Glial Derived Neurotrophic Factor (AF) 2 65 10 165 100 535 1 5,280 IL-6 (AF) 300-09AF Rat Interleukin-6 (AF) 2 65 10 165 100 535 1 5,280 5 Catalog Name listed in bold = also available in Animal Free HUMAN PROTEINS 6 Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price Activin A 100-43 Human Activin A 2 60 10 150 100 485 1 4,800 Artemin 100-23 Human Artemin 5 60 20 150 100 375 1 2,700 BAFF 100-24 Human BAFF 5 60 20 150 100 485 1 4,800 BCA-1 / CXCL13 100-27 Human Beta-cell Attracting Chemokine 1 5 60 20 150 100 375 1 2,700 BDNF 100-01 Human Brain Derived Neurotrophic Factor 2 60 20 150 100 485 1 4,800 BMP-2 100-53 Human Bone Morphogenetic Protein-2 2 60 10 150 100 485 1 4,800 CD40-Ligand 100-25 Human CD40 Ligand 10 60 50 150 NA NA 1 1,200 Chemerin 100-36 Human Chemerin 5 60 25 150 100 375 1 2,700 CNTF 100-59 Human Ciliary Neurotrophic Factor 5 60 20 150 100 375 1 2,700 CTGF 100-60 Human Connective Tissue Growth Factor 5 60 20 150 100 375 1 3,200 EGF 100-26 Human Epidermal Growth Factor 100 60 500 150 NA NA 1 EG-VEGF 100-07 Human Endocrine Gland Vascular Endothelial Growth Factor 5 60 20 150 100 375 1 2,700 FGF-acidic 100-29 Human Fibroblast Growth Factor acidic 10 60 50 150 NA NA 1 1,200 FGF-basic 147 100-28 Human Fibroblast Growth Factor 147 basic 10 60 50 150 NA NA 1 1,200 FGF-basic 154 100-146 Human Fibroblast Growth Factor 154 basic 10 60 50 150 NA NA 1 1,000 FGF-4 100-31 Human Fibroblast Growth Factor-4 5 60 25 150 100 375 1 2,700 FGF-21 100-148 Human Fibroblast Growth Factor-21 5 60 20 150 100 375 1 2,700 FGF-22 100-68 Human Fibroblast Growth Factor-22 5 60 20 150 100 485 1 4,600 FLT-3 Ligand 100-21 Human Flt-3 Ligand 2 60 10 150 100 375 1 3,600 Follistatin 100-41 Human Follistatin 5 60 20 150 100 485 1 4,800 Fractalkine 100-174 Human Fractalkine 5 60 20 150 100 375 1 2,700 gACRP-30 100-156 Human globular ACRP-30 5 60 25 150 100 375 1 2,700 Galectin-1 100-30 Human Galectin-1 10 60 50 150 NA NA 1 1,200 Galectin-3 100-154 Human Galectin-3 10 60 50 150 NA NA 1 1,200 G-CSF 100-72 Human Granulocyte Colony Stimulating Factor 2 60 10 150 100 485 1 4,800 GDF-5 100-71 Human Growth and Differentiation Factor-5 10 60 50 150 NA NA 1 1,200 GDF-15 100-171 Human Growth and Differentiation Factor-15 5 60 20 150 100 375 1 3,500 GDF-15-D 100-172 Human Growth and Differentiation Factor-15 (D variant) 5 60 20 150 100 375 1 3,500 GDNF 100-02 Human Glial Derived Neurotrophic Factor 2 60 10 150 100 485 1 4,800 GH 100-40 Human Growth Hormone 100 60 500 150 NA NA 5 GM-CSF 100-08 Human Granulocyte Macrophage Colony Stimulating Factor 5 60 20 150 100 375 1 2,800 GRO-α / CXCL1 100-32 Human GRO-alpha 5 60 25 150 100 375 1 2,700 GRO-β / CXCL2 100-123 Human GRO-beta 2 60 10 150 100 375 1 2,700 GRO-γ/ MIP-2 β/ CXCL3 100-170 Human GRO-gamma 2 60 10 150 100 375 1 2,700 IFN-α 2a 100-54 Human Interferon-alpha 2a 20 60 100 150 NA NA 1 900 IFN-α 2b 100-52 Human Interferon-alpha 2b 20 60 100 150 NA NA 1 900 IFN-γ 100-77 Human Interferon-gamma 20 60 100 150 NA NA 1 1,000 IGF-I 100-34 Human Insulin-like Growth Factor I 20 60 100 150 NA NA 1 IGF-II 100-14 Human Insulin-like Growth Factor II 10 60 50 150 NA NA 1 1,100 IL-1α / IL-1F1 100-173 Human Interleukin-1 alpha 2 60 10 150 100 485 1 4,800 IL-1β 100-167 Human Interleukin-1 beta 2 60 10 150 100 375 1 3,600 Mg Price 220 600 250 Catalog Name listed in bold = also available in Animal Free HUMAN PROTEINS, CONTINUED Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price IL-2 100-12 Human Interleukin-2 10 60 50 150 NA NA 1 IL-3 100-80 Human Interleukin-3 2 60 10 150 100 375 1 2,700 IL-4 100-09 Human Interleukin-4 5 60 20 150 100 375 1 3,600 IL-6 100-10 Human Interleukin-6 5 60 20 150 100 375 1 2,700 IL-7 100-11 Human Interleukin-7 2 60 10 150 100 485 1 4,800 IL-9 100-82 Human Interleukin-9 2 60 10 150 100 485 1 4,800 IL-10 100-83 Human Interleukin-10 2 60 10 150 100 485 1 4,800 IL-11 100-84 Human Interleukin-11 2 60 10 150 100 485 1 4,800 IL-13 100-85 Human Interleukin-13 2 60 10 150 100 485 1 4,800 IL-15 100-86 Human Interleukin-15 2 60 10 150 100 375 1 3,600 IL-16 100-144 Human Interleukin-16 2 60 10 150 100 485 1 4,800 IL-17A 100-87 Human Interleukin-17A 5 60 25 150 100 375 1 2,700 IL-17AF Heterodimer 100-161 Human Interleukin-17AF Heterodimer 5 60 25 150 100 485 1 4,800 IL-17E / IL-25 100-149 Human Interleukin-17E 5 60 25 150 100 375 1 2,700 IL-17F 100-152 Human Interleukin-17F 5 60 25 150 100 375 1 2,700 IL-19 100-88 Human Interleukin-19 2 60 10 150 100 485 1 4,800 IL-20 100-89 Human Interleukin-20 2 60 10 150 100 485 1 4,800 IL-21 100-90 Human Interleukin-21 2 60 10 150 100 485 1 4,800 IL-22 100-91 Human Interleukin-22 2 60 10 150 100 485 1 4,800 IL-27 / IL-35 (EBI3) 100-162 Human Epstein-Barr Virus Induced Gene 3 5 60 20 150 100 485 1 4,800 IL-29 100-169 Human Interleukin-29 5 60 20 150 100 375 1 2,700 IL-32α 100-151 Human Interleukin-32 alpha 2 60 10 150 100 485 1 4,800 IL-33 100-145 Human Interleukin-33 2 60 10 150 100 485 1 4,800 IP-10 / CXCL10 100-127 Human IP-10 5 60 25 150 100 375 1 2,700 I-TAC / CXCL11 100-128 Human ITAC 5 60 20 150 100 375 1 2,700 Leptin 100-37 Human Leptin 200 60 1,000 150 NA NA 5 LIF 100-47 Human Leukemia Inhibitory Factor 5 60 25 150 100 375 1 2,500 MCP-1 / CCL2 100-13 Human Monocyte Chemotactic Protein-1 5 60 20 150 100 375 1 2,700 MCP-2 / CCL8 100-130 Human Monocyte Chemotactic Protein-2 2 60 10 150 100 375 1 2,700 MCP-3 / CCL7 100-131 Human Monocyte Chemotactic Protein-3 2 60 10 150 100 375 1 2,700 MCP-4 / CCL13 100-132 Human Monocyte Chemotactic Protein-4 5 60 20 150 100 375 1 2,700 M-CSF 100-03 Human Macrophage Colony Stimulating Factor 2 60 10 150 100 485 1 4,800 MIF 100-153 Human Migration Inhibitory Factor 5 60 25 150 100 375 1 2,700 MIP-1α / CCL3 100-15 Human Macrophage Inflammatory Protein-1 alpha 5 60 20 150 100 375 1 2,700 MIP-1β / CCL4 100-134 Human Macrophage Inflammatory Protein-1 beta 2 60 10 150 100 375 1 2,700 MIP-3α / CCL20 100-147 Human Macrophage Inflammatory Protein-3 alpha 5 60 20 150 100 375 1 2,700 MIP-3β / CCL19 100-135 Human Macrophage Inflammatory Protein-3 beta 5 60 20 150 100 375 1 2,700 MIP-4 / CCL18 100-136 Human Macrophage Inflammatory Protein-4 2 60 10 150 100 375 1 2,700 Myostatin 100-22 Human Myostatin 2 60 10 150 100 485 1 4,800 Myostatin Propeptide 100-142 Human Myostatin Propeptide 5 60 25 150 100 485 1 4,800 Mg Price 650 220 7 Catalog Name listed in bold = also available in Animal Free HUMAN PROTEINS, CONTINUED Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price NGF-β 100-38 Human Nerve Growth Factor beta NRG1-β 100-46 Mg Price 5 60 20 150 100 375 1 2,700 Human Neuregulin 1-beta 10 60 50 150 NA NA 1 1,200 NT-3 100-99 Human Neurotrophin-3 2 60 10 150 100 485 1 4,800 NT-4 100-33 Human Neurotrophin-4 2 60 10 150 100 485 1 4,800 PDGF-AA 100-16 Human Platelet Derived Growth Factor-AA 2 60 10 150 100 375 1 3,500 PDGF-AB 100-17 Human Platelet Derived Growth Factor-AB 2 60 10 150 100 375 1 3,500 PDGF-BB 100-18 Human Platelet Derived Growth Factor-BB 2 60 10 150 100 375 1 3,500 Procalcitonin 100-164 Human Procalcitonin 2 60 10 150 100 485 1 4,800 100-45 Human Prolactin 10 60 50 150 NA NA 1 1,200 RANK Ligand 100-19 Human soluble RANK Ligand 2 60 10 150 100 485 1 4,800 Prolactin RANTES / CCL5 100-138 Human RANTES 5 60 20 150 100 375 1 2,700 RELM-β 100-160 Human RELM beta 5 60 25 150 100 375 1 2,700 Resistin 100-107 Human Resistin Dimer 5 60 25 150 100 485 1 4,800 SCF 100-04 Human Stem Cell Factor 2 60 10 150 100 375 1 2,600 SDF-1α / CXCL12 100-20 Human Stromal Cell-Derived Factor-1 alpha 2 60 10 150 100 375 1 2,700 SDF-1β / CXCL12 100-159 Human Stromal Cell-Derived Factor-1 beta 2 60 10 150 100 375 1 2,700 SHH 100-168 Human Sonic Hedgehog 5 60 25 150 100 375 1 2,500 TARC / CCL17 100-42 Human TARC 5 60 20 150 100 375 1 2,700 TGF-β 1 100-39 Human Transforming Growth Factor beta 1 1 60 5 150 100 1,950 1 8,800 TGF-β 3 100-109 Human Transforming Growth Factor beta 3 2 60 10 150 100 585 1 5,800 TNF-α 100-111 Human Tumor Necrosis Factor alpha 10 60 50 150 NA NA 1 1,200 TNF-Receptor-1 100-35 Human Tumor Necrosis Factor Receptor Type 1 5 60 20 150 100 375 1 2,700 TPO 100-05 Human Thrombopoietin 2 60 10 150 100 485 1 4,000 TRAIL 100-115 Human TRAIL 10 60 50 150 NA NA 1 1,200 TSLP 100-165 Human Thymic Stromal Lymphopoietin 2 60 10 150 100 485 1 4,800 VEGF-121 100-116 Human Vascular Endothelial Growth Factor-121 2 60 10 150 100 485 1 3,600 VEGF-165 100-44 Human Vascular Endothelial Growth Factor-165 2 60 10 150 100 375 1 3,600 100-50 Human Visfatin 5 60 25 150 100 375 1 2,700 Mini, ug Price Std., ug Price Value, ug Price 2 60 10 150 100 375 Visfatin FELINE PROTEINS 8 Catalog Name Catalog # Product SDF-1β / CXCL12 400-01 Feline Stromal Cell-Derived Factor-1 beta Mg Price 1 2,700 Catalog Name listed in bold = also available in Animal Free MOUSE PROTEINS Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price Activin A 200-29 Mouse Activin A 2 60 10 150 100 485 1 4,800 CD40-Ligand 200-10 Mouse CD40 Ligand 5 60 25 150 100 375 1 2,700 EGF 200-53 Mouse Epidermal Growth Factor 100 60 500 150 NA NA 1 Exodus-2 200-35 Mouse Exodus-2 / CCL21 FGF-9 200-13 Mouse Fibroblast Growth Factor 9 FGF-acidic 200-48 FGF-basic Mg Price 220 5 60 20 150 100 375 1 2,700 2 60 10 150 100 375 1 3,600 Mouse Fibroblast Growth Factor acidic 10 60 50 150 NA NA 1 1,200 200-12 Mouse Fibroblast Growth Factor basic 10 60 50 150 100 NA 1 1,200 FLT-3 Ligand 200-06 Mouse FLT-3 Ligand 2 60 10 150 100 375 1 3,600 Follistatin 200-24 Mouse Follistatin 5 60 20 150 100 485 1 4,800 G-CSF 200-14 Mouse Granulocyte Colony Stimulating Factor 2 60 10 150 100 485 1 4,800 GDNF 200-37 Mouse Glial Derived Neurotrophic Factor 2 60 10 150 100 485 1 4,800 GM-CSF 200-15 Mouse Granulocyte Macrophage-Colony Stimulating Factor 5 60 20 150 100 375 1 2,800 GRO-α / CXCL1 200-23 Mouse GRO-alpha /KC 5 60 20 150 100 375 1 2,700 IFN-γ 200-16 Mouse Interferon gamma 20 60 100 150 100 NA 1 1,000 IGF-I 200-05 Mouse Insulin-like Growth Factor I 10 60 50 150 100 NA 1 1,200 IL-1β 200-68 Mouse Interleukin-1 beta 2 60 10 150 100 485 1 4,800 IL-2 200-17 Mouse Interleukin-2 5 60 20 150 100 375 1 2,500 IL-3 200-01 Mouse Interleukin-3 2 60 10 150 100 485 1 4,000 IL-4 200-18 Mouse Interleukin-4 2 60 10 150 100 375 1 3,400 IL-5 200-20 Mouse Interleukin-5 5 60 25 150 100 375 1 2,700 IL-6 200-02 Mouse Interleukin-6 2 60 10 150 100 485 1 3,800 IL-7 200-03 Mouse Interleukin-7 2 60 10 150 100 485 1 4,800 IL-9 200-19 Mouse Interleukin-9 2 60 10 150 100 485 1 4,800 IL-11 200-64 Mouse Interleukin-11 2 60 10 150 100 485 1 4,800 IL-12 200-25 Mouse Interleukin-12 (p70) 2 60 10 150 100 1,200 1 7,200 IL-13 200-22 Mouse Interleukin-13 2 60 10 150 100 485 1 4,800 IL-15 200-07 Mouse Interleukin-15 2 60 10 150 100 375 1 3,600 IL-16 200-49 Mouse Interleukin-16 2 60 10 150 100 485 1 4,600 IL-17A 200-59 Mouse Interleukin-17A 5 60 25 150 100 375 1 2,700 IL-17AF Heterodimer 200-61 Mouse Interleukin-17AF Heterodimer 5 60 25 150 100 485 1 4,800 IL-17E / IL-25 200-60 Mouse Interleukin-17E 5 60 25 150 100 375 1 2,700 IL-17F 200-62 Mouse Interleukin-17F 5 60 25 150 100 375 1 2,700 IL-21 200-70 Mouse Interleukin-21 2 60 10 150 100 485 1 4,800 IL-27 / IL-35 (EBI3) 200-57 Mouse Epstein-Barr Virus Induced Gene 3 2 60 10 150 100 485 1 4,800 IL-27 (p28) 200-50 Mouse p28 2 60 10 150 100 485 1 4,800 IL-31 200-71 Mouse Interleukin-31 2 60 10 150 100 485 1 4,800 IL-33 200-36 Mouse Interleukin-33 2 60 10 150 100 485 1 4,800 IP-10 / CXCL10 200-38 Mouse IP-10 5 60 25 150 100 375 1 2,700 Leptin 200-26 Mouse Leptin 200 60 1,000 150 NA NA 1 450 LIF 200-33 Mouse Leukemia Inhibitory Factor 5 60 20 150 100 485 1 4,800 MCP-1 / CCL2 200-39 Mouse Monocyte Chemotactic Protein-1 2 60 10 150 100 375 1 2,700 MCP-2 / CCL8 200-63 Mouse Monocyte Chemotactic Protein-2 2 60 10 150 100 375 1 2,700 MCP-3 / CCL7 200-40 Mouse Monocyte Chemotactic Protein-3 2 60 10 150 100 375 1 2,700 M-CSF 200-08 Mouse Macrophage Colony Stimulating Factor 2 60 10 150 100 485 1 4,800 MIP-1α / CCL3 200-42 Mouse Macrophage Inflammatory Protein-1 alpha 2 60 10 150 100 375 1 2,700 9 Catalog Name listed in bold = also available in Animal Free MOUSE PROTEINS, CONTINUED Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price MIP-1β / CCL4 200-43 MIP-3α / CCL20 200-51 MIP-3β / CCL19 200-44 Mouse Macrophage Inflammatory Protein-3 beta Mg Price Mouse Macrophage Inflammatory Protein-1 beta 2 60 10 150 100 375 1 2,700 Mouse Macrophage Inflammatory Protein-3 alpha 5 60 20 150 100 375 1 2,700 5 60 20 150 100 375 1 2,700 NGF-β 200-11 Mouse Nerve Growth Factor beta 5 60 20 150 100 375 1 2,700 NT-3 200-21 Mouse Neurotrophin-3 2 60 10 150 100 485 1 4,800 PDGF-AA 200-54 Mouse Platelet Derived Growth Factor AA 2 60 10 150 100 375 1 3,500 PDGF-BB 200-58 Mouse Platelet Derived Growth Factor BB 2 60 10 150 100 375 1 3,500 RANK Ligand 200-04 Mouse soluble RANK Ligand 2 60 10 150 100 485 1 4,800 RANTES / CCL5 200-45 Mouse RANTES 5 60 20 150 100 375 1 2,700 RELM-α 200-28 Mouse RELM alpha 5 60 25 150 100 375 1 2,700 RELM-β 200-69 Mouse RELM beta 5 60 25 150 100 375 1 2,700 Resistin 200-30 Mouse Resistin Dimer 5 60 25 150 100 485 1 4,800 SCF 200-09 Mouse Stem Cell Factor 2 60 10 150 100 375 1 2,700 SDF-1α / CXCL12 200-46 Mouse Stromal Cell-Derived Factor-1 alpha 2 60 10 150 100 375 1 2,700 SDF-1β / CXCL12 200-67 Mouse Stromal Cell-Derived Factor-1 beta 2 60 10 150 100 375 1 2,700 SHH 200-55 Mouse Sonic Hedgehog 5 60 25 150 100 375 1 2,500 TGF-β 3 200-27 Mouse Transforming Growth Factor beta 3 2 60 10 150 100 585 1 5,800 TNF-α 200-31 Mouse Tumor Necrosis Factor alpha 5 60 20 150 100 375 1 2,700 TPO 200-32 Mouse Thrombopoietin 2 60 10 150 100 485 1 4,000 VEGF-120 200-52 Mouse Vascular Endothelial Growth Factor-120 2 60 10 150 100 375 1 3,600 VEGF-165 200-34 Mouse Vascular Endothelial Growth Factor-165 2 60 10 150 100 375 1 3,600 RAT PROTEINS 10 Catalog Name Catalog # Product Mini, ug Price Std., ug Price Value, ug Price Activin A 300-06 Rat Activin A 2 60 10 150 100 485 Mg 1 4,800 Price EGF 300-05 Rat Epidermal Growth Factor 20 60 100 150 NA NA 1 FGF-9 300-27 Rat Fibroblast Growth Factor-9 2 60 10 150 100 375 1 3,600 FGF-basic 300-02 Rat Fibroblast Growth Factor-basic 10 60 50 150 NA NA 1 1,200 GDNF 300-10 Rat Glial Derived Neurotrophic Factor 2 60 10 150 100 485 1 4,800 GM-CSF 300-03 Rat Granulocyte Macrophage-Colony Stimulating Factor 5 60 20 150 100 375 1 2,800 IFN-γ 300-04 Rat Interferon gamma 20 60 100 150 NA NA 1 1,000 IGF-I 300-01 Rat Insulin-like Growth Factor I 10 60 50 150 NA NA 1 1,200 IL-1β 300-30 Rat Interleukin-1 beta 2 60 10 150 100 485 1 4,800 IL-6 300-09 Rat Interleukin-6 2 60 10 150 100 485 1 4,800 IL-17A 300-24 900 Rat Interleukin-17A 5 60 25 150 100 375 1 3,800 IL-17AF Heterodimer 300-29 Rat Interleukin-17AF Heterodimer 5 60 25 150 100 485 1 4,800 IL-17E / IL-25 300-25 Rat Interleukin-17E 2 60 10 150 100 375 1 3,600 IL-17F 300-28 Rat Interleukin-17F 5 60 25 150 100 375 1 2,700 Leptin 300-14 Rat Leptin 200 60 1,000 150 NA NA 5 MCP-1 / CCL2 300-22 Rat Monocyte Chemotactic Protein-1 2 60 10 150 100 375 1 2,700 MCP-3 / CCL7 300-07 Rat Monocyte Chemotactic Protein-3 2 60 10 150 100 375 1 2,700 MIP-1α / CCL3 300-23 Rat Macrophage Inflammatory Protein-1 alpha 5 60 20 150 100 375 1 2,700 RANTES / CCL5 300-26 Rat RANTES 5 60 20 150 100 375 1 2,700 SCF 300-32 Rat Stem Cell Factor 2 60 10 150 100 375 1 2,700 TNF-α 300-18 Rat Tumor Necrosis Factor alpha 5 60 20 150 100 375 1 2,700 VEGF-165 300-31 Rat Vascular Endothelial Growth Factor-165 2 60 10 150 100 375 1 3,600 425 Introducing Shenandoah’s New Protein Bundles • Convenient ordering with 1 catalog number • 20% Cost Savings Verses Buying Each Individual Vial • Products are still supplied in separate vials to let you customize your protocol HUMAN PROTEIN BUNDLES Catalog Name Unit Includes Catalog Number 2 x 100 ug of Human EGF 4 x 50 ug of Human FGF-basic 154 100 ug of Human PDGF-AA 100 ug of Human PDGF-BB PB-500-19 1470 1176 Human Hematopoietic Progenitor Cell Expansion Bundle A cytokine bundle for rapidly expanding immature and more mature hematopoietic progenitor cells (CD34+ cells) from cord blood or bone marrow preparations. 10 ug SCF 10 ug FLT-3 Ligand 20 ug IL-6 10 ug IL-3 PB-500-07 600 480 Human Hematopoietic Stem Cell Expansion Bundle A cytokine bundle for rapidly expanding the most immature hematopoietic stem cells (CD34+ cells) from cord blood or bone marrow preparations. 10 ug TPO 10 ug SCF 10 ug FLT-3 Ligand PB-500-03 450 360 100 ug GM-CSF 100 ug IL-4 PB-500-01 750 600 Human Neural Stem Cell 100 ug of Human EGF Expansion Protein Bundle 2 x 50 ug of Human FGF-basic 154 A cytokine bundle for expanding and maintaining undifferentiated neural stem cells (NCSs). PB-500-17 360 288 Human Th9 Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the Th9 subset. 20 ug of IL-4 5 ug of TGF-β 1 PB-500-15 300 240 Human Th17 Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the Th17 subset. 20 ug of IL-6 5 ug of TGF-β 1 PB-500-11 300 240 Human Th17 Cell Polarizing Plus Bundle A cytokine bundle for differentiating naive T cells to the Th17 subset with additional cytokines (IL-21 and IL-1 beta) commonly used in Th17 studies. 20 ug of IL-6 5 ug of TGF-β 1 100 ug of IL-21 10 ug of IL-1 β PB-500-12 935 750 Human T Reg Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the T Reg subset. 1 mg of IL-2 5 ug of TGF-β 1 PB-500-09 800 640 Human Glioma Culture Media Protein Bundle A cytokine bundle for culturing ex vivo neural tumor cells such as DIPG cells. Human Monocyte/DC Protein Bundle A cytokine bundle for culturing immature dendritic cells from peripheral blood monocytes. Retail Price Bundle Price 11 MOUSE PROTEIN BUNDLES Catalog Name Unit Includes Catalog Number Retail Price Bundle Price Mouse Glioma Culture Media Protein Bundle 2 x 100 ug of Mouse EGF A cytokine bundle for culturing ex vivo 4 x 50 ug of Mouse FGF-basic neural tumor cells. 100 ug of Mouse PDGF-AA 100 ug of Mouse PDGF-BB PB-500-20 1470 1176 Mouse Hematopoietic Progenitor Cell Expansion Bundle A cytokine bundle for rapidly expanding immature and more (CD34+ cells) from cord blood or bone marrow preparations. 10 ug SCF 10 ug FLT-3 Ligand 10 ug IL-6 10 ug IL-3 PB-500-08 600 480 Mouse Hematopoietic Stem Cell Expansion Bundle A cytokine bundle for rapidly expanding the most immature hematopoietic stem cells (CD34+ cells) from cord blood or bone marrow preparations. 10 ug SCF 10 ug TPO 10 ug FLT-3 Ligand PB-500-04 450 360 100 ug GM-CSF 100 ug IL-4 PB-500-02 750 600 Mouse Neural Stem Cell 100 ug of Mouse EGF Expansion Protein Bundle 2 x 50 ug of Mouse FGF-basic A cytokine bundle for expanding and maintaining undifferentiated neural stem cells (NCSs). PB-500-18 360 288 Mouse Th9 Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the Th9 subset. 20 ug of IL-4 5 ug of TGF-β 1 PB-500-16 450 360 Mouse Th17 Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the Th17 subset. 20 ug of IL-6 5 ug of TGF-β 1 PB-500-13 450 360 20 ug of IL-6 5 ug of TGF-β 1 10 ug of IL-1 β 100 ug of IL-21 PB-500-14 1085 870 100 ug of IL-2 5 ug of TGF-β 1 PB-500-10 525 420 Mouse Monocyte/DC Protein Bundle A cytokine bundle for culturing immature dendritic cells from peripheral blood monocytes. Mouse Th17 Cell Polarizing Plus Bundle A cytokine bundle for differentiating naive T cells to the Th17 subset with additional cytokines (IL-21 and IL-1 beta) commonly used in Th17 studies. Mouse T Reg Cell Polarizing Bundle A cytokine bundle for differentiating naive T cells to the T Reg subset. 12 POLYCLONAL ANTIBODIES Target Label Source Size (ug) Catalog Number Price Human BDNF Unlabeled Rabbit Ig Fraction Clone 100 PAR-100-BDNF 225 Human GM-CSF Unlabeled Rabbit Ig Fraction 100 PAR-100-GMCSF 225 Human IL-1β Unlabeled Rabbit Ig Fraction 100 PAR-100-IL1B 225 Human IL-2 Unlabeled Rabbit Ig Fraction 100 PAR-100-IL2 225 Human IL-3 Unlabeled Rabbit Ig Fraction 100 PAR-100-IL3 225 Human IL-4 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL4 225 Human IL-6 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL6 225 Human IL-7 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL7 225 Human IL-9 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL9 225 Human IL-17A Unlabeled Rabbit IgG Fraction 100 PAR-100-IL17A 225 Human IL-17F Unlabeled Rabbit IgG Fraction 100 PAR-100-IL17F 225 Human IL-27 / IL-35 (EBI3) Unlabeled Rabbit IgG Fraction 100 PAR-100-EBI3 225 Human IL-29 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL29 225 Human IL-32α Unlabeled Rabbit IgG Fraction 100 PAR-100-IL32A 225 Human IL-33 Unlabeled Rabbit IgG Fraction 100 PAR-100-IL33 225 Human MCP-1 Unlabeled Rabbit IgG Fraction 100 PAR-100-MCP1 225 Human MIP-1β Unlabeled Rabbit IgG Fraction 100 PAR-100-MIP1B 225 Human MIP-3α Unlabeled Rabbit IgG Fraction 100 PAR-100-MIP3A 225 Human VEGF-121 Unlabeled Rabbit IgG Fraction 100 PAR-100-VEGF121 225 Human VEGF-165 Unlabeled Rabbit IgG Fraction 100 PAR-100-VEGF165 225 Mouse GM-CSF Unlabeled Rabbit IgG Fraction 100 PAR-200-GMCSF 225 Mouse IL-1β Unlabeled Rabbit IgG Fraction 100 PAR-200-IL1B 225 Mouse IL-6 Unlabeled Rabbit IgG Fraction 100 PAR-200-IL6 225 Mouse IL-17F Unlabeled Rabbit IgG Fraction 100 PAR-200-IL17F 225 Mouse IL-27 / IL-35 (EBI3) Unlabeled Rabbit IgG Fraction 100 PAR-200-EBI3 225 Mouse IL-27 (p28) Unlabeled Rabbit IgG Fraction 100 PAR-200-P28 225 Mouse MIP-1α Unlabeled Rabbit IgG Fraction 100 PAR-200-MIP1A 225 Mouse MIP-3α Unlabeled Rabbit IgG Fraction 100 PAR-200-MIP3A 225 Mouse RANK Ligand Unlabeled Rabbit IgG Fraction 100 PAR-200-RANKL 225 Rat IL-17A Unlabeled Rabbit IgG Fraction 100 PAR-300-IL17A 225 13 MONOCLONAL ANTIBODIES Target Reactivity Source, Isotype Clone Size (ug) Unlabeled Catalog # Unlabeled Price Biotinylated Catalog # Biotinylated Price Human IL-6 H Mouse, IgG1/k 33A12 100 MAB-100-IL6 225 MAB-100-IL6BIO 250 Human IL-17A H Mouse IgG2b/k 4H1524 100 MAB-100-IL17A 225 MAB-100-IL17ABIO 250 Human IL-17E H Mouse IgG1/k 11K8B1 100 MAB-100-IL17E 225 MAB-100-IL17EBIO 250 Human IL-17F H Mouse IgG1/k 4H1629 100 MAB-100-IL17F29 225 MAB-100-IL17F29BIO 250 Human IL-17F H Mouse IgG1/k 4H450 100 MAB-100-IL17F50 225 MAB-100-IL17F5BIO 250 Mouse IL-17A M Rat, IgG2a/k 20B4 100 MAB-200-IL17A 225 MAB-200-IL17ABIO 250 Mouse IL-27/p28 M Rat, IgG2a/k 3H12 100 MAB-200-P28 225 MAB-200-P28BIO 250 Mouse IL-35/IL-27 (EBI3) H, M Mouse, IgG2b/k V1.4C4.22 100 MAB-200-IL3522 350 MAB-200-IL3522BIO 400 Mouse IL-35/IL-27 (EBI3) H, M Mouse, IgG2b/k V1.4F5.25 100 MAB-200-IL3525 350 MAB-200-IL3525BIO 400 Mouse IL-35/IL-27 (EBI3) H, M Mouse, IgG2b/k V1.4H6.29 100 MAB-200-IL3529 350 MAB-200-IL3529BIO 400 3 EASY WAYS TO ORDER: ORDER BY PHONE: 877.613.6020 ORDER BY EMAIL: ORDERS@SHENANDOAH-BT.COM ORDER ONLINE: WWW.SHENANDOAH-BT.COM 14 USING SHENANDOAH PRODUCTS PAYS! Publish a scientific paper using Shenandoah Biotechnology products and receive a product credit valued at $200. Follow these steps to get $200 in free Shenandoah products: • Buy a Shenandoah protein and use it in your experiments. • Reference Shenandoah Biotechnology in your methods when you publish. • Fill out and submit the Publication Credit Form (available on our website at http://www.shenandoah-bt.com/sbt/promotional-offers), complete with a PDF copy of your publication. Terms and Conditions: 1. The submitted publication must be from a peer reviewed journal and have been published within 24 months of the date of submission. 2. Only ONE credit will be provided per publication, but any author may apply for the credit. 3. Credit is subject to validation of product, reference in the article methods by Shenandoah Biotechnology. 4. The credit does not apply to shipping, it cannot be divided between multiple purchases, and no portion of the credit can be exchanged for cash. 5. Offer is valid to any customer, but it is the submitter’s responsibility to accurately complete and submit the Publication Credit Form and adhere to the redemption instructions supplied with the credit. 6. Promotional code will be valid for ONE year after the issue date 15 We are your “One-Stop Protein Shop”! SHENANDOAH OFFERS: • Custom Protein Expression (cloning to active protein) • Inclusion Body Purification • Protein Folding • Bulk Orders (> 10 mg quantities of catalog products) WHY BUY SHENANDOAH: • 4 Convenient Product Sizes • High Quality Products • Made in the USA • Competitive Pricing • Overnight Domestic Shipping • Woman Owned Enterprise Certification • Great Customer and Technical Support www.shenandoah-bt.com CONTACT US PHONE 877.613.6020 FAX 877.617.9530 EMAIL INFO@SHENANDOAH-BT.COM WEB WWW.SHENANDOAH-BT.COM 16