D e pa r t m e n t o f M e d i c i n e
T h e Wa r r e n A l per t M e d i ca l S c h o o l o f B r ow n U n i v er s i t y
De pa r t m e n t o f M edicin e
Academic Years 2008 and 2009
A ca d e mic Y e ar s 2 0 0 8 a n d 2 0 0 9
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The Warren Alpert Medical School of
Brown University Department of Medicine
Administrative Offices
Rhode Island Hospital
Main Building, 1st Floor
593 Eddy Street
Providence, RI 02903
j u ly 1, 2 0 0 7– J u n e 3 0 , 2 0 0 9
Rhode Island Hospital/Hasbro Children’s Hospital
The Miriam Hospital
Memorial Hospital of Rhode Island
Women & Infant’s Hospital
Veteran’s Administration Medical Center
Patient Care,
Teaching & Research
Rhode Island Hospital/Hasbro Children’s Hospital
The Miriam Hospital
Memorial Hospital of Rhode Island
Women & Infant’s Hospital
WWW.BROWNMEDICINE.ORG
Veteran’s Administration Medical Center
◆
j u ly 1, 2 0 0 7– J u n e 3 0 , 2 0 0 9
B r o w n U n i v e r s i t y, P r o v i d e n c e ,
and New England
January 2011 The Warren Alpert Medical School of Brown University
Editor
Tricia Meehan
Design
Brian Prosnitz
Brown University Graphic Services
Photography
Constance Brown
Lucas Foglia
Scott Kinsley
Rob Pike
Len Rubenstein
Women & Infant’s Hospital Media Center
Special thanks to the following
for their contributions:
Dora Bethel, Sandy Bibby, Barbara Bottone, Dan Bryant, Denise Carbone, Sharon Chiott,
Jane Conti-Dutko, Maria DaRocha, Faye Hall, Doreen Hoogasian, Jenna Houle, Lucy Kwiek,
Denise Lavely-O’Hara, Margaret Malo, Kathy Poland, and Charleen Pysz
B
rown University and Providence, Rhode
Island together provide a pleasant and
interesting setting for study, recreation,
and daily life. From atop College Hill the
University overlooks downtown Providence, the
capital of Rhode Island and the second largest
city in New England. The University was founded
in 1764. Its architecturally diverse buildings and
quadrangles center on the original College Green.
In the surrounding residential area are houses that
date back to colonial times, together with various
historic sites, including the Old State House,
where independence in America was first declared
and the First Baptist Meeting House, the oldest
Baptist Church in America.
Contemporary life in Providence complements
the city’s interesting history. One can walk from
the campus to a variety of restaurants, to the
nationally renowned Trinity Square Repertory or
to a jazz club or dance performance. Attractions
also include several art galleries, including the
Rhode Island School of Design Museum of Art.
On the Brown campus are plays, concerts, movies,
lectures, art exhibits, and many other sources
of entertainment and intellectual stimulation
throughout the year. A modern athletic complex
within easy walking distance from the main
campus offers swimming in a modern Olympicsized pool, externsive exercise equipment, squash
and tennis courts, and ice-skating, as well as
playing fields and facilities for intramural and
varsity team sports.
Rhode Island is especially known for recreational
opportunities centered on the ocean and
Narragansett Bay, including boating, fishing,
sailing, and swimming. Newport, the site of some
of the nation’s most magnificent mansions and
for many years home of the America’s Cup sailing
races, is less than an hour away. Providence is an
hour by car, bus or train from Boston, an hour
from Cape Cod, about three hours from major
New Hampshire and Vermont ski areas, and three
and a half hours from New York City. At the
T.F. Green Airport, ten minutes from downtown
Providence, several major airlines offer frequent
service to all major points in the United States.
T h e Wa r r e n A l per t M e d i ca l S c h o o l o f B r ow n U n i v er s i t y
De pa r t m e n t o f M edicin e
Academic Years 2008 and 2009
◆
j u ly 1, 2 0 0 7– J u n e 3 0 , 2 0 0 9
Rhode Island Hospital/Hasbro Children’s Hospital
The Miriam Hospital
Memorial Hospital of Rhode Island
Women & Infant’s Hospital
Veteran’s Administration Medical Center
◆
Introduction and Overview
Comments from the Chairman...............................................2
Department of Medicine Organization...................................4
Department of Medicine Faculty Data....................................5
Chairman’s Associates..............................................................6
Division Highlights
Cardiology............................................................................ 10
Endocrinology.......................................................................22
Gastroenterology and Hepatology.........................................26
General Internal Medicine.....................................................32
Geriatrics...............................................................................50
Hematology/Oncology..........................................................57
Hospitalist Program..............................................................65
Infectious Diseases................................................................70
Kidney Disease and Hypertension.........................................88
Obstetric & Consultative Medicine.......................................96
Pulmonary, Critical Care & Sleep Medicine........................ 108
Rheumatology..................................................................... 119
Memorial Hospital of Rhode Island.................................... 121
Providence VA Medical Center............................................ 123
◆
◆
international health.................................................. 133
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Grand Rounds................................................................ 137
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Clinical activity.......................................................... 140
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Research overview...................................................... 141
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Affiliated Hospitals..................................................... 143
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Brown, Providence & New England............. back cover
1
introduction and overview
Lance D. Dworkin, M.D. is the Interim Chairman of Medicine and a Professor of
Medicine at Warren Alpert Medical School and for its five affiliated hospitals. He
serves as Interim Physician-in-Chief of Rhode Island & The Miriam Hospitals and
Interim Executive Physician-in-Chief of Memorial Hospital of RI, Women & Infants
Hospital and the VA Medical Center.
Dr. Dworkin graduated from the University of Pennsylvania School of Medicine
and completed his internship and residency at New York University/Bellevue
Hospital in NYC. He also completed clinical and research fellowships in
Nephrology at Harvard Medical School/Peter Bent Brigham Hospital in Boston, MA.
Dr. Dworkin joined the faculty at Brown in 1993 where he served as the
Division Director of Kidney Disease and Hypertension and the Vice Chairman
of Research & Academic Affairs.
COMMENTS FROM THE CHAIRMAN
Dr. Dworkin conducts laboratory research on the mechanisms of progressive
kidney failure and its prevention. He is also a clinical specialist in hypertension.
2
T
he past two years have been a time of significant
challenges, but also of tremendous opportunity
and growth for the Department of Medicine of
the Warren Alpert Medical School. Despite a difficult
economic climate and a rapidly evolving health care
system, the Department has continued to experience remarkable success in its clinical, educational and research
missions. Notable has been the recruitment of over 70
new physicians and faculty into our ranks who have invigorated our academic and clinical programs. Our core
residency and fellowship programs remain extremely
strong, attracting outstanding physicians to train in our
institutions each year. Many of these programs recently
underwent a very positive external review, receiving
high marks and long term renewals. The purpose of this
report is to highlight some of the significant accomplishments of our faculty and trainees during the 2008
and 2009 academic years.
Developing new models for the delivery of primary care
that improve patient outcomes while controlling costs
has become a priority for the nation. The Department
has devoted considerable attention to this issue and is
helping to design and actively participating in novel
health maintenance and disease management programs.
Drs. Frank Basile and Tom Bledsoe have spearheaded
the development of the patient centered medical home;
an advanced primary care practice model where comprehensive care is provided by a physician led team and is
personalized to the patient’s own, self-management goals.
The team, which includes medical assistants, patient educators, nutrition, pharmacy, mental health professionals
and other medical specialists, commits to populationbased care using an electronic medical record and outcome tracking. Over the next year, we hope to extend
this model to include many of the primary care practice
sites within the Department. Coincident with this effort,
an integrated electronic medical record is being implemented that will knit together the patient records and
outpatient practices of many of the full-time faculty in
the Department. This tool will greatly facilitate our ability to track patient outcomes and to improve the quality
of medical care in the outpatient setting.
Within our hospitals, the Hospital Medicine Division
has experienced explosive growth over the past two
years. The expanding role of hospital physicians has
been driven by recent trends in medical practice and
medical education. The number of community based
practitioners who elect to follow their patients during
a hospital admission has been progressively declining.
At the same time, limitations on housestaff work hours
have reduced the number of patients that are admitted and followed by residents. Led by Sajeev Handa at
Rhode Island Hospital and by Kwame Dapaah-Afriyie
at The Miriam Hospital, the Division of Hospital Medicine has more than tripled in size and now includes over
50 physicians. This talented team of doctors provides
high quality, integrated clinical care to majority of
patients admitted to medicine at these institutions. In
addition, our hospitalists are increasingly involved in
resident and medical student education and play an
important role in assessing and improving the quality of
medical care for our patients.
This past year, the Alpert Medical School in collaboration with Women and Infant’s Hospital, established a
new Division of Obstetrical Medicine, making us the
first Department of Medicine in the United States with
such a division. Led by Dr. Karen Rosene-Montella, the
program in Obstetric Medicine at Women & Infants
a c a d e m i c y e a r s 20 08 a n d 20 09
Hospital has existed for more than sixteen years, during
which time it has grown into a multidisciplinary division with an international reputation. Clinically, the
obstetric medicine practice sees thousands of patients
annually for medical problems in pregnancy and perinatal behavioral health. Academically, the new Division
houses the only Obstetric Medicine Fellowship in the
US and has developed the obstetric medicine curricula
for internal medicine trainees both nationally and internationally. The Presidents of both the North American
and International Societies of Obstetric Medicine are
members of the Division. The division also includes
active research programs examining a broad array of
topics including thrombosis prevention, prediction of
pre-eclampsia, detection and management of hypothyroidism, and sleep disturbances in pregnancy. The
new academic division will continue to serve as a major
resource to physicians, patients and trainees learning
and working in this important area.
Clinical and academic programs have also continued
to grow at the VA, under the leadership of Dr. Sharon
Rounds and at Memorial Hospital under the direction
of Dr. Andrew Artenstein. This has included the addition of new faculty in many divisions, ongoing participation in our internal medicine resident and fellowship
training programs, and continued success of the research
programs at both hospitals, which attract significant
extramural funding. One notable accomplishment was
the funding of a new T32 training grant in cardiopulomonary medicine that is jointly led by the Director
of the Cardiovascular Research Center at Rhode Island
Hospital, Dr. Gideon Koren, and by Dr. Sharon Rounds
at the VA, who also directs a multi-institutional vascular
biology research program. The new Center for Biodefense and Emerging Pathogens at Memorial Hospital
directed by Dr. Andy Artenstein has continued its successful role both within Brown and within Rhode Island.
Dr. Artenstein, along with the Center’s Associate Director, Dr. Peggie Neill at Memorial Hospital, have provided community based education around biodefense to
a variety of medical and public safety personnel. Center
physicians provide round the clock consultative services
for the RI Department of Health for bioterrorism
concerns. Dr. Peggie Neill chairs the Bioterrorism Work
Group for the Infectious Disease Society of America and
has played a major role in educating infectious disease
physicians on these issues since 9/11.
International health remains an important area of
focus for the Medical School and for the Department. In 2009, Brown University launched the Global
Health Initiative (GHI), a multidisciplinary universitywide program to address health inequalities among
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
underserved populations worldwide. Susan Cu-Uvin,
Professor of Obstetrics and Gynecology and Medicine
is the Director of the GHI; many other Department
faculty on its Executive Committee and/or participating in its programs. Department members are actively
engaged in providing care, teaching, and conducting
research in many countries including Kenya, Ghana, the
Dominican Republic, Haiti, China, India, and Vietnam
to name a few. Established by Dean Edward Wing
when he was Chair of the Department, and by Dr. Jane
Carter, the partnership with Moi University in Eldoret,
Kenya has been thriving for more than 10 years and has
expanded beyond HIV and infectious diseases to include collaborative programs in diabetes, oncology, and
nephrology. These international programs allow faculty,
students and trainees to experience medical practice
outside our normal confines and also provide a wealth
of opportunities for service, education and research.
Research in the Department has remained strong despite a challenging funding climate. Extramural support
for research within the Department averages about $40
million dollars per year; the vast majority of grants are
from federal sources. For example, in the past year, the
Oncology program was awarded two separate COBRE
grants that together will bring over $20 million dollars
of direct support for cancer research to the Department over the next five years. Exciting work is ongoing
and significant new funding has also been obtained by
department faculty in cardiovascular medicine, liver
and gastroenterology, kidney disease and hypertension, general internal medicine, infectious disease and
immunology, diabetes and endocrinology, all of which
have robust translational and basic research programs.
In 2009, the Department launched a new developmental grant program designed to support young investigators and to position them to compete successfully for
extramural funding. Important goals in the coming
years are to continue to expand the research portfolio
in the Department, as well as to develop more extensive
collaborative programs and centers with investigators on
the Brown campus and throughout our multi-hospital
system that will cross traditional institutional barriers.
It has been my privilege and a great honor to serve as
Interim Chair of the Department for the past two years.
Most of all, I have enjoyed and benefited from the opportunity to work closely with the outstanding group of
faculty, trainees, and staff that make up the Department.
Our success is entirely the result of their remarkable
intelligence, dedication, and hard work, of which I see
evidence every day and in every activity. It is satisfying to
know that, with such talented academicians and professionals in place, the future of the Department is bright.
3
introduction and overview
D e pa r tm e n t o f M e d i c i n e
O r g a n i z at i o n
Office of
the Chairman
D e pa r tm e n t
A d m i n i st r at i o n
Lance D. Dworkin, M.D.
Interim Chairman of Medicine
Interim Physician-in-Chief, Rhode Island and The
Miriam Hospitals
Executive Physician-in-Chief, Memorial Hospital
of Rhode Island, VA Medical Center,
Women and Infants Hospital
Professor of Medicine
Peter Ceriani, MBA
Administrator, Rhode Island and
The Miriam Hospitals
CEO, University Medicine Foundation
Fred J. Schiffman, M.D.
Professor of Medicine
Vice Chairman of Medicine
Associate Director of Categorical and Preliminary
Internal Medicine Residency Programs,
The Miriam Hospital
Dominick Tammaro, M.D.
Associate Professor of Medicine
Director of Internal Medicine Residency,
Associate Chief for Clinical Affairs,
Rhode Island Hospital
Dan Bryant
Research Administrator, Rhode Island and
The Miriam Hospitals
Denise Lavely-O’Hara
Administrator, Internal Medicine Graduate Medical
Education
Tricia Meehan
Administrative Coordinator, Faculty Actions
Mena Orabano
Administrative Secretary
Division
Division Chief
Cardiology
Alfred Buxton, M.D.
Endocrinology
Robert Smith, M.D.
Gastroenterology and Hepatology
Jack Wands, M.D.
General Internal Medicine
Mark Fagan, M.D.*
Geriatrics
Richard Besdine, M.D.
Hematology/Oncology
Peter Quesenberry, M.D.
RIH Hospitalist Medicine
Sajeev Handa, M.D.
TMH Hospitalist Medicine
Kwame Dapaah-Afryie, M.D.
Infectious Diseases
Timothy Flanigan, M.D.
Kidney Disease and Hypertension
Douglas Shemin, M.D.*
Obstetric & Consultative Medicine
Karen Rosene-Montella, M.D.
Pulmonary, Critical Care & Sleep Medicine
Mitchell Levy, M.D.*
Rheumatology
Edward Lally, M.D.
*Interim
4
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DEPARTMENT OF MEDICINE FACULTY DATA
TOTAL537
Full-Time157
Clinical294
Emeritus36
Adjunct28
Secondary22
FACULTY BY DIVISION
DivisionFull-TimeClinicalEmeritusAdjunctSecondaryTotal
Cardiology
2257 5 2 1 87
Endocrinology
59 22 018
Gastroenterology
1422 6 0 1 43
General Internal Medicine
25
Geriatrics
83 00 011
138
5
3
12
183
Hematology/Oncology 1916 8 3 3 49
31
Nephrology
1314 2 2 0 31
Pulmonary/Critical Care
18
Rheumatology
24 23 011
Total
11
20
2
4
10
3
5
59
Infectious Diseases
0
11
157294 36 28 22 537
FACULTY BY HOSPITAL
HospitalFull-TimeClinicalEmeritusAdjunctSecondaryTotal
Butler
21 10 04
Kent
03 00 02
Landmark
01 00 01
Memorial
1337 6 1 0 57
Miriam
2991 8 4 8140
RIH
93126 17 12 10258
RWMC
05 08 013
St. Joseph
0
VAMC
1422 4 2 1 43
W&I
65 00 314
Charlton Memorial
0
URI
00 01 01
Total
157294 36 28 22 537
1
2
0
0
0
0
0
0
1
2
5
introduction and overview
CHAIR M AN ’ S
A S S OCIAT E S
A
s Vice Chairman of the Department of Medicine, Dr. Fred J. Schiffman assumes several roles.
He works closely with Dr. Lance Dworkin running the day-to-day clinical activities of the Department
of Medicine at The Miriam Hospital. The educational,
clinical and administrative programs of the Brown University Department of Medicine at The Miriam Hospital
are Dr. Schiffman’s direct responsibility. He is especially
involved with the education of medical students and
residents and the continuing education of office-based
and hospital-based faculty. He works together with the
medical chief residents to organize and run formal and
informal teaching activities. Additionally, quality assurance and improvement programs for the Department
of Medicine at The Miriam Hospital are an important
part of this position. He is involved in planning Medical
Grand Rounds and co-leads the Committee on Clinical
Appointments and Promotions. He is also the Medical
Director of the Lifespan Comprehensive Cancer Center.
The Department is especially pleased about the new Baxt
Pavilion which holds very pleasant and functional conference space, state-of-the-art radiology equipment and the
finest operating rooms available. Thirty-six additional patient beds occupy the third floor with beautiful and highly
functional patient rooms and family and nursing areas.
The Miriam’s clinical services are populated by patients
who have a very high “case mix index” reflecting serious
multi-system disease. The majority of these challenging
patients are ministered to by house staff and attending
physician teams on the wards and in the Critical Care
Unit. A new hematology/oncology inpatient team was
instituted this past July (2009). Hospitalists work closely
with medical residents, and side-by-side make diagnostic
and therapeutic choices. Attending rounds are conducted by full-time and office-based practitioners, many
of whom have won Department of Medicine Teaching
Awards. Nursing care is on a high plane, and The Miriam
Hospital boasts winning the Magnet Award for Nursing
(a four year award) three times (1998, 2002, 2006).
Academic, full time groups admit approximately 35%
of patients to The Miriam Hospital and also lead and
participate in several research projects. The Infectious
Diseases Division is especially active here. The Center
for AIDS Research Grant for the federal government is
led by Dr. Charles C.J. Carpenter and has been renewed
an unprecedented three times, and also participate in
the AIDS Clinical Trials Group (ACTG). Most of the
6
Fred J. Schiffman, M.D., Professor of Medicine, Vice Chairman of Medicine,
Associate Director of Categorical and Preliminary Internal Medicine
Residency Programs, The Miriam Hospital
other members of this division are actively engaged in
projects of their own.
Many of the Department of Medicine’s international
programs have been spearheaded by Miriam Hospital
physicians and students, residents, fellows and attending
physicians benefit from these relationships. The Cardiology Division boasts about being a five time Solucient
Award winner and its members are actively involved
with teaching and research as well as expert clinical care.
The Hematology/Oncology Division has an extraordinarily active clinical program. Its members lead or
participate in a large number of research projects. For
example, Dr. Howard Safran is an international expert
in upper GI malignancies and chairs medical oncology
for the Radiation Therapy Oncology Group (RTOG).
Wednesday morning’s Morbidity and Mortality Conference is regarded as a premier teaching and quality assurance and improvement vehicle. It is attended by the
entire medical staff; as many of the interesting patients
presented are further described in medical publications.
Department of Medicine faculty work closely with the
surgical faculty and over the last two years, have begun a
highly popular and educational combined medical/surgical teaching rounds. This is conducted by medical and
surgical attending physician leaders and participated in
by medical students and house staff.
The Miriam Hospital has always aspired to take its place
among the best academic community hospitals in the
country. Its reputation will be secure as we continue to
be mindful of the imperatives of superb patient care and
a meaningful academic vision.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
CHAIR M AN ’ S
A S S OCIAT E S
D
ominick Tammaro was appointed as Associate
Chief of Clinical Affairs in March 2006 and
was recently appointed Residency Director for
the Department of Medicine in July, 2008. As Residency Director, Dr. Tammaro provides oversight of the
operations and development of educational programs,
faculty recruitment, and the coordination of educational
programs. Dr. Tammaro also serves as the Director of
the General Medicine Inpatient Consultation Service,
providing medical consultation and support for patients
on services outside the Department of Medicine. In
his role as Associate Chief, Dr. Tammaro is responsible
for inpatient clinical programs in the Department of
Medicine. He is responsible for the day-to-day clinical
operations in the Department of Medicine at Rhode Island Hospital and oversees the educational, clinical, and
administrative aspects of these programs. Dr. Tammaro
serves as the Department of Medicine’s liaison with the
Departments of Nursing and Laboratory Medicine as
well as other clinical departments, such as Emergency
Medicine and Neurology.
The residency programs continue to thrive and demonstrate strong performance in both objective and
subjective quality measures. Resident recruitment has
remained strong, with Categorical, Primary Care and
Med/Peds all demonstrating best Match Day performances for the last 10 years. Applications to the Internal
Medicine residencies are up 15% this year and for
Med-Peds, an impressive 50% increase in applications
was seen. ABIM Certification Exam pass rates and Fellowship Match performance remain strong as well. We
are proud to see an increasing number of our graduates
among the ranks of program directors and associate
program directors at the annual Association of Program
Directors in Internal Medicine meetings.
The leadership team for the Internal Medicine Residency programs has evolved and expanded. Dr. Kelly
McGarry continues her excellent leadership as Program
Director of the Primary Care Program, developing new
initiatives in Professionalism education and Performance Improvement for residents. Dr. Fred Schiffman continues to contribute his years of experience
in graduate medical education as Associate Residency
Director at the Miriam Hospital. Dr. Jennifer Jeremiah
serves as Associate Residency Director and is primarily
Dominick Tammaro, M.D., Associate Professor of Medicine,
Director of Internal Medicine Residency, Associate Chief for Clinical Affairs,
Department of Medicine, Rhode Island Hospital
responsible for the program’s Community Based Teaching Program, in which residents spend ½ day per week
in community primary care and subspecialty offices
over the course of their PGY-2 and PGY-3 years. She
has also led our team in the development of new evaluation and faculty development initiatives. Finally, Dr.
Ravi Gupta joins the residency leadership team as our
newest Associate Residency Director after completing
his chief resident year. Dr. Gupta directs the Preliminary Internal Medicine Program and is involved both
in developing new evaluation tools as well as utilizing
simulation as an educational tool.
The last two academic years have been marked by
growth and development in several areas. both the
clinical and educational aspect of the Department of
Medicine’s missions. The Internal Medicine residency
programs have continued to thrive and to adapt in
the changing health care environment. For example, a
steady increase in admission volume to the Department of Medicine has lead to further expansion of the
hospitalist groups at both Rhode Island Hospital and
the Miriam Hospital in an effort to keep pace with this
expanding patient population, while maintain a strict
ceiling on house staff admissions and census in compliance with ACGME guidelines. A partnership between
the Department of Medicine and both the Rhode
7
introduction and overview
Island and Miriam Hospitals has been key in managing
this growth successfully. The Division of Hospitalist
Medicine is now the largest division within the Department of Medicine.
A new inpatient ward design at Rhode Island Hospital, begun in 2006, has enjoyed continued success and
growth. Faculty and fellows in Hematology/Oncology
and Nephrology have been working closely together
and the resulting experience for medical housestaff
has added diversity and depth to their experience. A
new Primary Care Service has built upon a successful
foundation of community-based internist educators
who participate in both ambulatory primary care as well
as inpatient hospitalist care. This blended model has
resulted in a unique and valuable experience for medical residents. The success of the hematology/oncology
inpatient service at Rhode Island Hospital has led to
the creation of a similar team at Miriam, which has met
with similar success, owing in large part to the commitment to this experience by faculty and fellows. The
program continues to evolve and capitalize on strengths
of the Department of medicine and core institutions.
The Physical Plants at both Rhode Island Hospital and
the Miriam Hospital have undergone extensive renovation and modernization over the last two years. The
new Baxt Building at Miriam provides patient-focused
clinical care space with provision for family and provider amenities. State of the art conference facilities are
also part of this new addition. The new Bridge Building
at Rhode Island Hospital houses a spacious new CCU
and Intermediate Cardiac Care Unit, as well as spacious
modern general medical floors with ample computer
and provider spaces. Finally, a large-scale renovation and
modernization of the Jane Brown Building, where most
of the Internal Medicine teaching service patients are
located, is nearing completion as of this writing.
8
Just as the last several years have seen growth and success in the Internal Medicine residency programs in our
department, the next several years appear to hold the
same promise with major improvements in both the
physical plant as well as the flexibility to care for a growing population of patients who represent an extraordinary diversity of ethnic background, socioeconomic status and disease spectrum. The residency programs will
continue to incorporate competency-based education
and evaluation techniques in order to assure that new
physicians are trained in the same hands-on manner for
which these programs have been recognized, while enhancing the focus on performance improvement, quality
of care, and patient safety.
divisions
9
cardiology
DIVI S ION OF
CARDIOLOGY
OVERVIE W
T
he Cardiology Division has grown in both
clinical and research activity over the past two
years. In addition to local growth, members
of the Division hold key leadership positions on the
national and international level. Dr. J. Dawn Abbott
holds a principal position in the NIH-funded Dynamic
Registry of Interventional Catheterization. Dr. Abbott
also played a major role in a new initiative to improve
the care of patients with acute myocardial infarction.
Working in collaboration with members of the Emergency Department, and coincident with the opening of
a unique new cardiac catheterization laboratory in the
Emergency Room at Rhode Island Hospital (RIH), this
collaboration led to a dramatic reduction in the “door
to balloon time” for acute interventions of patients with
myocardial infarction. This effort resulted in a national
award for excellence. Dr. Athena Poppas, Director of
the Rhode Island Hospital Echocardiography Laboratory, Chaired the Women’s Cardiovascular Committee of
the American College of Cardiology (ACC) and served
as a member of the Women in Cardiology Committee
of the American Heart Association (AHA). Dr. Poppas
also serves on several committees of the American Society of Echocardiography. Dr. James Arrighi, Director
of Nuclear Cardiology at RIH, Chaired the Integrated
Imaging Spotlight Committee for the ACC 2008 Annual Scientific Meeting. He served on the Abstract Selection Committee of the AHA, and is Secretary of the
Board of Directors of the American Society of Nuclear
Cardiology. Dr. Brian Abbott Co-Chaired the Integrated Imaging Spotlight Committee for the ACC 2009
Annual Scientific Meeting. Dr. Abbott served on the
Board of Directors of the American Society of Nuclear
Cardiology. Dr. Peter Tilkemeier served on the Writing Committee to develop clinical data standards for
cardiac imaging of the American College of Cardiology
Foundation, and also served on the Program Committee
of the American Society of Nuclear Cardiology Annual
Meeting. Alfred Buxton chaired both the Joint American Heart Association (AHA)/ACC and Heart Rhythm
Society (HRS) Committee on Electrophysiology Data
Standards. Dr. Buxton served on the American Board of
Internal Medicine Test Writing Committee on Electrophysiology and Interventional Cardiology.
10
Alfred Buxton, M.D., Professor of Medicine
Director, Division of Cardiology
The Cardiovascular Research Center (CVRC) made
noteworthy progress and achievements from 2007–
2009. Dr Koren, Director of the CVRC serves on
an NIH study section. Dr. Ulrike Mende, faculty in
the CVRC, has been recognized internationally for
her research investigating mechanisms of intracellular
signaling, utilizing G proteins. Dr. Mende served on
several NIH Panels. CVRC research grant funding
increased by over 50% for the 2008–2009 academic
year with the funding of a new T32 Cardiopulmonary
training grant, as well as a new RO1. Research exploring
mechanisms of arrhythmias responsible for sudden cardiac death is a major focus of the CVRC, and a model
of long QT syndrome utilized here is found nowhere
else in the world at this time. Groundbreaking research
exploring gender differences in risk for sudden death is
being recognized for the CVRC. The CVRC submitted a grant to establish a Cell Imaging Core facility. In
addition, the CVRC’s educational program continues to
thrive, involving both Brown graduate and undergraduate students. In addition, the CVRC recruited the first
group of four T32 fellows, a diverse and highly qualified group of trainees. Feedback from the students and
trainees is that the experience is very fulfilling and the
teaching is excellent.
a c a d e m i c y e a r s 20 08 a n d 20 09
The Cardiology Division of the Medical Service at the
Providence Veterans Administration Medical Center is
responsible for all inpatient cardiac care and for outpatient cardiology clinics. The inpatient team provides
consultation service to the ICU, acute med-surg units
as well as the emergency department. The division is
also responsible for outpatient cardiology clinics, which
consist of general cardiology clinics as well as subspecialty clinics including Pacemaker, CHF and cardiac
risk reduction clinics. In addition, scheduled outpatient
procedures such as cardioversions and TEE are performed in the ambulatory day treatment unit. Inpatient
procedures are performed in the ICU and the PACU.
Satish Sharma, M.D. is Chief of Cardiology as well as
the Director of the Specialty and Acute Care service line
for the VA New England Healthcare System (VISN 1).
Wen-Chih Wu, M.D., serves as the site director for the
fellowship program, and Gaurav Choudhary, M.D., is
the director of outpatient cardiology.
The Cardiology at the Veterans Administration Medical Center (VAMC) division is an integral part of the
Brown University program and provides two regular rotations for the general cardiology fellows, the inpatient
consultation service and the non-invasive testing service.
In addition, the division has been approved recently
by the Brown University GME office for a 1-2 year fellowship in preventive cardiology. VA faculty members
participate as lecturers in the core curriculum lecture
series for the cardiology fellows. At the VAMC, a weekly
EKG reading session for internal medicine residents as
well as a one-month cardiology elective for medicine
residents from the Brown University affiliated hospitals
is provided. All faculty members participate as lecturers
in the cardiology lecture series of the core curriculum
of the medicine residents. The faculty members also
provide a quarterly EKG course for the Brown University 3rd year Medical Students as part of their core curriculum in internal medicine. In addition, a one-month
cardiology elective for medical students is offered. The
VAMC faculty members are active participants in the
second year Pathophysiology course at the Alpert Medical School of Brown University as small group leaders
(Choudhary) and lecturers (Wu, Choudhary, Shin). As
Section editor for Ferri’s Clinical Advisor, Dr. Wu in
conjunction with Dr. Choudhary, has worked with
fellows (cardiology, pulmonary, preventive cardiology)
and internal medicine residents on book chapters in the
current review of multiple specialized topics of interest
(25 book chapters).
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
The clinical cardiology fellowship program continues
to recruit outstanding candidates from major residency
programs throughout the country. The core fellowship
program includes six trainees per year for a minimum
of three years. The first two years are dedicated to
mastering the core aspects of clinical cardiology, and are
comprised of required rotations in each of the major
disciplines of cardiology (consultative and diagnostic
cardiology, noninvasive imaging, heart failure, electrophysiology, and catheterization). The third year is
tailored to the individual’s career goals. Accredited
programs in interventional cardiology and clinical cardiac electrophysiology are offered as well. Participation
of fellows in a research experience within the Division
and Department is expected, and provides a foundation of ongoing scholarship and critical thinking that is
required for any career in medicine.
Over the past two years, there have been several initiatives that have focused on improving education and/
or patient care. Our program has been selected as one
of three fellowships nationally to evaluate a new online
“teaching portfolio” being developed by the American
College of Cardiology. Also, we have acquired a new
online teaching resource through the ACC, called
Cardiosource, that provides fellows and faculty with a
wealth of teaching materials, CME activities, and meetings demand. The fellows’ Cardiology Clinic in APC5
continues to thrive, delivering cardiology services to the
underserved and needy population of Rhode Island. Finally, the interventional cardiology fellowship programs
of Rhode Island and Miriam Hospitals have merged
into one single program, under the leadership of Dr.
J. Dawn Abbott. This will allow more robust program,
and will facilitate educational and research interactions
among faculty and trainees.
The nuclear cardiology laboratory at Rhode Island
Hospital is directed by Dr. James Arrighi. The laboratory performs approximately 2000 SPECT studies per
year, utilizing the most state-of-the-art techniques. The
laboratory maintains a database, and is actively involved
in clinical research. Likewise at The Miriam Hospital
(TMH), the nuclear cardiology laboratory is directed by
Dr. Peter Tilkemeier. Dr. Tilkemeier has been recognized nationally for his work enumerating standards
for nuclear cardiology imaging facilities. Dr. Tilkemeier
served as a member of the ACC Quality in Imaging
Summit in addition to the ACC Writing Committee for
cardiac imaging data standards.
11
cardiology
Drs. Tilkemeier and Arrighi have collaborated to create a unified reporting system for nuclear cardiology
imaging between Rhode Island and Miriam Hospitals.
Cardiac positron emission tomography (PET) remains a
small, but unique program, offering myocardial viability
studies in patients with severe coronary disease and left
ventricular dysfunction.
The nuclear laboratory also is involved in clinical
research projects in several areas. We currently are conducting a pilot study that evaluates fluorodeoxyglucose
uptake by PET in peripheral arteries, as a sign of worsening peripheral artery disease. Another study that investigated the utility of stress myocardial perfusion imaging
prior to bariatric surgery was presented at a national
cardiology meeting, and is in the final stages of submission of the paper. The lab continues to be a valuable
resource for resident research. Ongoing resident projects
include analysis of the appropriateness of myocardial
perfusion studies performed in the Chest Pain Unit; the
interaction of workload and gender on the incidence of
ischemia in exercise stress testing; and the significance of
severe ST depression with normal perfusion images.
The Cardiac Arrhythmia Program and Clinical Electrophysiology Laboratory continued to see growth in clinical activity. The atrial fibrillation ablation program has
grown several fold, aided by acquisition of state-of-theart 3 dimensional mapping systems that facilitate precise
localization of foci of arrhythmia. An active collaboration with Dr. Michael Atalay (Diagnostic Imaging) has
integrated cardiac magnetic resonance imaging (MRI)
with electrophysiologic studies enhancing the performance of clinical ablation for ventricular tachycardia. In
addition, an active research program utilizing cardiac
MRI supported by a local seed grant has resulted in new
understanding of structural requirements for development of ventricular arrhythmias and sudden death after
myocardial infarction. Dr. Kristin Ellison initiated a
new program extracting leads from implanted pacemakers and defibrillators. This type of high risk service
requires extraordinary collaboration between cardiology and cardiothoracic surgery, and is only available in
selected centers in the country.
The electrophysiology service opened a new clinical
laboratory at The Miriam Hospital (TMH) in October
2008 that now permits implantation of sophisticated
cardiac pacemakers and defibrillators. This has enhanced
patient care, reducing hospital stays at TMH. The
12
clinical database at TMH is fully integrated with the
RIH database facilitating integrated patient care across
the Lifespan system.
The cardiac catheterization laboratories at RIH and
TMH provide state of the art diagnostic and interventional services for coronary as well as peripheral vascular
disease. The response times for intervention in acute
myocardial infarction lead national standards.
The echocardiography laboratory at RIH, under the
direction of Dr Athena Poppas, continues to grow
in breath and depth in both the clinical and research
arenas. The laboratory performs over 8000 transthoracic,
500 transesophageal and 500 stress echo studies each
year. The laboratory has eight state of the art echocardiography carts, two dedicated stress echo rooms and
one for transesophageal procedures; the lab is all digital
with all reports being immediately available on line. The
laboratory works closely with interventional cardiology
for collaborative procedures in the catheterization laboratory and with cardiac anesthesia to perform intraoperative transesophageal studies.
The Rhode Island Heart Failure Program is one of the
busiest in New England, and continues to increase clinical activity. Pre-transplant evaluations and post transplant
care occupy significant resources, including performance
of endomyocardial biopsies. The program actively provides sophisticated cardiopulmonary exercise testing.
The adult congenital heart disease clinic meets three
times monthly and is staffed by Drs. Philip Stockwell,
Thomas Drew, and Robert Corwin of the pediatric
cardiology division. The clinic continues to grow as
patients transition from the care of their pediatric cardiologist during their late teenage years or early twenties.
We offer on site echocardiography and have benefited
greatly from the assistance of Michael Atalay, M.D. of
Diagnostic Imaging, who interprets the MRI studies of
these complex patients. In addition, the service has been
developing ties with regional centers when specialized
procedures become necessary.
f a c u lt y m e mb e r s
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Alfred Buxton, M.D., Director
Gideon Koren, M.D.
Albert Most, M.D.
Satish Sharma, M.D.
Associate Professors
James Arrighi, M.D.
Jonathan Elion, M.D.
Kenneth Korr, M.D.
George McKendall, M.D.
Ulrike Mende, M.D.
Athena Poppas, M.D.
Barry Sharaf, M.D.
Peter Tilkemeier, M.D.
Assistant Professors
Jinette Dawn Abbott, M.D.
Michael Atalay, M.D., Ph.D.
Bum-Rak Choi, Ph.D.
Guarav Choudhary, M.D.
Kristin Ellison, M.D.
Malcolm Kirk, M.D.
Wen-Chih Wu, M.D.
Instructors
Karim Roder, Ph.D.
Victor Shin, M.D.
Peng Zhang, M.D.
Clinical Faculty
(Hospital and Foundation Based)
Associate Professors
Thomas Drew, M.D.
Assistant Professors
Brian G. Abbott, M.D.
Karen E. Asprey, M.D.
Eric Berger, M.D.
Douglass Burtt, M.D.
Fredric Christian, M.D.
Thomas Crain, M.D.
David Fortunato, M.D.
Michael Gilson, M.D.
Paul Gordon, M.D.
Gary Katzman, M.D.
Edward Keating, M.B.
Daniel Levine, M.D.
Peem Lovidhaya, M.D.
Roger Raymond, M.D.
James Robertson, M.D.
Immad Sadiq, M.D.
Harry Schwartz, M.D.
Phillip Stockwell, M.D.
Marilyn J. Weigner, M.D
Joseph Yamine, M.D.
Teaching Associate
Susan Potter, RN
Volunteer Clinical Faculty
Associate Professors
Lauralyn Cannistra, M.D.
Andrew Hordes, M.D.
David Kitzes, M.D.
William Levin, M.D.
Robert Meringolo, M.D.
Barbara Roberts, M.D.
Ara Sadaniatz, M.D.
Assistant Professors
Anthony Cannistra, M.D.
Robert Carnevale, M.D.
Steven Fera, M.D.
Joseph Gaeta, M.D.
Peter Gibson, M.D.
Ned Gutman, M.D.
Suhdong Hahn, M.D.
Jack Klie, M.D.
Jon Lambrecht, M.D.
Christopher Luttmann, M.D.
Safiq Mamdani, M.D.
John F. Murphy, M.D.
Thomas E. Noonan, M.D.
Gisele I. Saliba, M.D.
Jay Schachne, M.D.
Robert Schwengel, M.D.
Mitchel A. Sklar, M.D.
Joseph Terlato, M.D.
Edward Thomas, M.D.
Instructors
Christopher Abadi, M.D.
John Cava, M.D.
Irving Gilson, M.D.
Michael Hyder, M.D.
Richard Regnante, M.D.
Hani Sabbour, M.D.
Franklin Schneider, M.D.
Joseph Spinale, D.O.
13
cardiology
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Brian Abbott, M.D.
James A. Arrighi, M.D.
Honors And Awards
◆◆
Member, Internal Medicine Residency
Review Committee, Accreditation Council
for Graduate Medical Education
Honors And Awards
Program Chair, American Society of
Nuclear Cardiology (ASNC) 12th Annual
Scientific Session, September 2007
◆◆
Vice President, Certification Board
of Nuclear Cardiology
◆◆
◆◆
Member, Board of Directors, American
Society of Nuclear Cardiology
Secretary, Board of Directors, American
Society of Nuclear Cardiology
◆◆
◆◆
Member, American Society of Nuclear
Cardiology, Education Committee
Chairman, Education Committee; Member,
Research Grants Committee and Abstract Selection
Committee, American Society of Nuclear Cardiology
◆◆
Member, American Society of Nuclear Cardiology
Scientific Session Program Committee
◆◆
Chairman, Integrated Imaging Spotlight Committee
(2008), American College of Cardiology
◆◆
Member, American Society of Nuclear Cardiology
Annual Meeting Organizing Committee
◆◆
Abstract Selection Committee, Annual Scientific
Sessions, American Heart Association
◆◆
Member, American Society of Nuclear Cardiology
Leadership DevelopmentCommittee
◆◆
Co-Chair, Annual Scientific Session “Imaging
Spotlight” Planning Committee
◆◆
Invited Pr esentations
◆◆
“Nuclear Cardiology: New Technologies and
Tracers”, American College of Cardiology
Annual Scientific Session, March 2009
J. Dawn Abbott, M.D. Invited Pr esentations
◆◆
“Basic nuclear cardiology: Isotopes, stressors,
protocols.” American College of Cardiology
Annual Scientific Session, March 2009.
◆◆
“Update in Cardiac SPECT.” American Roentgen
Ray Society Annual Meeting, May 2009
◆◆
“Physician Certification and Training in Nuclear
Cardiology.” International Conference of Nuclear
Cardiology, Prague, Czech Republic, May 2007
◆◆
“Mental Stress and Coronary Artery
Disease.” Cardiology Grand Rounds,
Montefiore Medical Center, Albert Einstein
School of Medicine, October 2007
Honors And Awards
◆◆
Associate Editor, Circulation:
Cardiovascular Interventions 2008
◆◆
Live Case Moderator, Peripheral Arterial Disease
Session, Cardiovascular Research Technologies
Conference, Washington, DC. March 5 2009.
Honors And Awards
◆◆
Recipient, Cardiovascular Research Technologies
Young Leadership Award 2009
◆◆
Expert Panel, American College of Radiology,
appropriateness criteria for cardiovascular imaging
◆◆
Member, Peripheral Vascular Disease Committee,
American College of Cardiology 2008
◆◆
Chairperson, Cardiopulmonary Imaging
section, American Roentgen Ray Society,
Annual Scientific Meeting 2009
◆◆
External Reviewer for the Appropriate Use Criteria
for Cardiac Computed Tomography through
the American College of Cardiology (ACC), on
behalf of the Society of Cardiovascular MR
Invited Pr esentations
◆◆
Washington Hospital Center Cardiac
Catheterization Conference, “Unrestricted use
of drug-eluting stents compared to bare-metal
stents in North America”, November 28, 2007
Schol arly Activities
14
Michael K. Atalay, M.D., Ph.D.
◆◆
Grant Study Section, American Heart
Association, REGION I, Cardiac
Biology 1 Study Group 2008, 2009
◆◆
NIH RO1 – Co-Investigator Dynamic Evaluation
of Coronary Intervention Renewal: Drug-Eluting
Stents. The goal of this project is evaluate the
safety and effectiveness of drug-eluting stent
(DES) in the practice of percutaneous coronary
intervention (PCI). (12/1/07–11/30/12)
Invited Pr esentations
◆◆
Introduction to Magnetic Resonance
Physics. Faculty New England Roentgen Ray
Society (Saturday Session), April 2008.
◆◆
Cardiac CT: Keynote address (Cardiac/
Chest CT Session). Faculty American
Roentgen Ray Society (ARRS), Annual
Meeting, Washington, DC, April 2008.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Cardiac MRI: The Basics. Faculty American
Roentgen Ray Society (ARRS), Annual
Meeting, Washington, DC, April 2008.
◆◆
“Rabbit model of Long QT Syndrome”
at Gordon Conference of cardiac
arrhythmia mechanisms. Italy, 2009
◆◆
Instructional Course: Getting the correct slice
position. Faculty Society of Cardiovascular
Magnetic Resonance (SCMR), Annual
Meeting, Orlando, FL, February 2009.
◆◆
“Discordant alternans in transgenic rabbit model
of long QT syndrome”, Korea University, 2008
◆◆
Cardiac MRI: The Basics. Faculty American
Roentgen Ray Society (ARRS), Annual
Meeting, Boston, MA, April 2009.
Schol arly Activities
◆◆
Principle Investigator - NIH R01– The
role of dynamic changes in repolarization
and calcium transients in Long QT
related arrhythmias (2009–2014)
Alfred E. Buxton, M.D.
Gaurav Choudhary, M.D.
Honors And Awards
Honors And Awards
◆◆
Member, American Board of Internal
Medicine, Test Writing Committee on
Clinical Cardiac Electrophysiology
◆◆
Chairman, Data and Safety Monitoring Board for
NHLBI – CABANA Trial (Catheter Ablation Versus
Anti-arrhythmic Drug Therapy for Atrial Fibrillation)
◆◆
Chairman, ACC/AHA/HRS Committee
on Electrophysiology Data Standards
◆◆
Castle-Connolly “America’s Top Doctors” 2007, 2008
◆◆
Northwestern University Young
Investigators’ Forum- Finalist, 2009
◆◆
Northwestern University Young
Investigators’ Forum- Third Prize, 2008
◆◆
Actelion Pharmaceuticals Young
Investigator Award, 2008
◆◆
Member: AHA Peer Review
Committee (Region I), 2009
◆◆
Member: AHA Peer Review
Committee (Region I), 2008
◆◆
Member: AHA NE Affiliate Peer
Review Committee, 2007
◆◆
Actelion Pharmaceuticals Young Investigator
Award, “Role of Endothelin-Induced PKC delta
Activation in Right Ventricular Hypertrophy”. 2008
Invited Pr esentations
◆◆
◆◆
American Heart Association Annual
Scientific Sessions, Cardiovascular Seminar:
“Identifying the High Risk Post-MI Patient.”
Orlando, FL November 5, 2007
Case Western Reserve University Cardiology Grand
Rounds. “Risk stratification for sudden death in
coronary disease.” Cleveland, OH April 10, 2008
◆◆
Heart Rhythm Society Annual Scientific
Sessions. Core Curriculum – “Potential
Adverse Effects of Inappropriate Shocks on the
Heart” San Francisco, CA May 16, 2008
◆◆
Cardiostim. “Sudden Cardiac Death and
Depressed EF – the Regulatory Agencies
Point of View” Nice, FR June 17, 2008
◆◆
American Society of Nuclear Cardiology
Annual Scientific Session – Advanced
Track – “Overview of Mechanisms of Cardiac
Arrhythmias” Boston, MA September 12, 2008
Schol arly Activities
◆◆
Co-Investigator, NIH R21 (5%FTE) – Effects
of Exercise on Autonomic Nervous System
Tone in Patients with Implanted Defibrillators
(Eva Serber, Ph.D. PI) 2008–2010
Bum Rak Choi, Ph.D.
Invited Pr esentations
◆◆
“Breaking waves in the heart”,
Northeastern University, 2008
Schol arly Activities
◆◆
Principal Investigator, VA Career Development
Award (VHA) “Role of C-type Natriuretic Peptide
in Pulmonary Vascular Function”. 2007–2010
Kristin E. Ellison, M.D.
Invited Pr esentations
◆◆
“Benefits of Cardiac Resynchronization Therapy in
Patients with Class Two Heart Failure” American
Heart Association, Orlando, November 2007
Gideon Koren, M.D.
Honors And Awards
◆◆
Principal Investigator of T32 CardioPulmonary
Training Grant, May 2008
◆◆
Member of NIH ESTA Study Section
◆◆
Member of the Data Safety Monitoring Board
of NHLBI-sponsored VEST/PREDICTS
Invited Pr esentations
◆◆
“The Female Heart” HRS Meeting,
San Francisco, June 2008
15
cardiology
Schol arly Activities
◆◆
Principle Investigator, NIH RO1, Trafficking
and subcellular distribution of cardiac
potassium channels (2004–2010)
◆◆
Principle Investigator, NIH R01, Heart and Muscle
K+ Channels: Assembly and Regulation (2005–2010)
◆◆
Principle Investigator, NIH RO1, Gender Related
Arrhythmias in LQT2 Rabbits (2008–2013)
Schol arly Activities
◆◆
Principle Investigator, NIH RO1 “RGS Regulation
of Cardiac Signaling and Hypertrophy (2006–2011)
◆◆
Principle Investigator, AHA Established
Investigator Award “G protein-mediated
Signaling and its Regulation by RGS Proteins
in Cardiac Fibroblasts” (2007–2011)
◆◆
Faculty Mentor, NIH P20 “COBRE
for Perinatal Biology” (2008–2013)
Gongxin Liu, M.D., Ph.D
Schol arly Activities
◆◆
◆◆
Characterization of Potassium currents expressed in
transgenic rabbit with dominant negative HERG
or KvLQT1 mutations over expressed in the heart.
Study single channel properties of Kv1.5 and Kv2.1
◆◆
Study interactions between HERG and KvLQT1.
◆◆
Characterization of mutations in Kir2.1
◆◆
Study cation channel in native mouse myocytes
George R. McKendall, M.D.
Athena Poppas, M.D.
Honors And Awards
◆◆
Chair, Women in Cardiology Committee,
American College of Cardiology, (2005–2009)
◆◆
Member, Digital Programming Editorial Board,
American College of Cardiology (2006–2008)
◆◆
Member, Scientific Sessions Program committee,
American Society of Echocardiography (2007–2008)
Invited Pr esentations
◆◆
Echocardiography Case Studies: Cardiac Masses,
Moderator and presenter: Twenty-fourth Annual
International Conference on Advances in
Echocardiography. Chicago IL, March 2008.
◆◆
Pericardial Constriction or Myocardial Restriction?
Echocardiography. American College of Cardiology
Scientific Sessions, Chicago, IL, March 2008.
◆◆
Women’s Career and Leadership Development
Conference. Program Co-Director. American College
of Cardiology Foundation. Dallas, TX, February 2008.
◆◆
Pregnancy and Heart Disease. Session
moderator and speaker, American Society of
Echocardiography. Toronto ON, June 2008.
◆◆
Endocarditis and Right Heart Catheters. American
Society of Echocardiography. Toronto, ON, June 2008
Honors And Awards
◆◆
Member, Credentialing and Membership Committee,
American College of Cardiology, 2006–Present
Ulrike Mende, M.D.
Honors And Awards
◆◆
Co-Chair, Region 1 - Cardiac Biology 1, American
Heart Association (April 2008, April 2009)
◆◆
Reviewer, Special Emphasis Panels, National Institutes
of Health (Feb 2008, June 2008, May 2009)
◆◆
Reviewer, Program Project Grant Review Panel,
National Institutes of Health (May 2008)
◆◆
Reviewer, Cardiac Contractility, Hypertrophy
and Failure Study Section, National
Institutes of Health (Oct 2008)
◆◆
Member, American Heart Association Founders
Affiliate Research Committee, (2008–2012)
Invited Pr esentations
◆◆
◆◆
16
“Regulators of G protein Signaling (RGS) in
the Heart”, invited lecture at the Foundation
Jagiellonian Medical Research Center as guest
of the Polish Academy of Arts and Sciences,
Krakow, Poland (November 2008)
“G-protein Signaling and Calcium Cycling“,
invited lecture at the annual meeting of the
International Society of Heart Research
(ISHR), Baltimore, M.D. (May 2009)
Schol arly Activities
◆◆
Co-Investigator, NIH RO1, Hemodynamic and
Cognitive 2007- Function in Cardiovascular Disease.
Karim Roder, Ph.D.
Schol arly Activities
◆◆
5-year Research Councils UK fellowship (2006–2011).
Peter Tilkemeier, M.D.
Honors And Awards
◆◆
Member, Quality in Imaging Summit, American
College of Cardiology Foundation, 2007
◆◆
Member, Program Committee, American
Society of Nuclear Cardiology Annual
Meeting, Core Track, 2008
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
Member, Writing Committee to develop clinical
data standards for cardiac imaging, American
College of Cardiology Foundation, 2009
◆◆
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Principle Investigator, VA HSR&DRRP 09–172
“Variations in Quality of Care and Outcomes
for Veterans with Heart Failure”, (2009–2010)
Invited Pr esentations
◆◆
“IHE and Nuclear Cardiology- 2007”, American
College of Cardiology, Annual Meeting, New
Orleans, Louisiana, March 25, 2007.
◆◆
“Evaluating and Improving Quality in Cardiovascular
Imaging: Challenges and Opportunities”,
American College of Cardiology, Annual
Meeting, Orlando, Florida, March 31, 2009.
S ELEC T ED P U B LICAT ION S
J. Dawn Abbott, M.D.
◆◆
Schol arly Activities
◆◆
Co-Investigator, NIH RO1 “Tailored Exercise
Support for Cardiac Patients” (2004–2008)
◆◆
Co-Investigator, NIH RO1 “Maintenance of
Exercise in Cardiac Rehabilitation” (2004–2008)
◆◆
Co-Investigator, NIH R21 “Cardiac
Autonomic Regulation Enhancement
Through Exercise” (2008–2010)
Wen-Chih Wu, M.D.
James A. Arrighi, M.D.
◆◆
Member, NIH Special Emphasis Panel/Scientific
Review Group 2009/10 ZRG1 HDM-P (58) R
◆◆
Faculty, NHLBI 1R25HL088992-01, ShortTerm Training Program to Increase Diversity
in Health-Related Research (2007–present)
Invited Pr esentations
◆◆
Wu WC. “Anemia and Acute Myocardial Infarction”,
Quality Scholars Conference Presenter, Dept.
of Veterans Affairs, Louis Stokes Cleveland VA
Medical Center. May 21st, 2009; Cleveland, Ohio
◆◆
Wu, WC. “Dyslipidemia in the Elderly, is it too
late to help?”, presenter at 2009 Senior Symposium
by the Connecticut Chapter of the American
Society of Consultant Pharmacists, Ledyard, CT.
◆◆
Wu WC, Kirsh S, Edelman D. Workshop Presenter
in “Inter-professional Diabetes Care: Research
and Operational Issues of Group Appointments”,
2008 VA HSR&D QUERI National Meeting,
December 10–12, 2008; Phoenix, AZ.
◆◆
Section Editor, Ferri’s Clinical Advisor, Ferri, FF
[ed], Elsevier, St. Louis. (2008–present)
◆◆
Co-Investigator, VA Patient Care Services VISN-1
Patient Safety Center of Inquiry, “PROVIDENCE
VAMC CHF Clinic” substudy, 2007–2009
◆◆
Principle Investigator, VA HSR&D IAB – 06–269
“Group Intervention for DM Guideline (2008–2012)
Hopkins R, Gitter H, Stave J, Bert A, Atalay M.
Stable partial dehiscence of aortic homograft inserted
freehand by using the subcoronary intra-aortic root
noncoronary sinus Ross scallop inclusion technique.
J Thorac Cardiovasc Surg 2008; 135(1):214–6.
Alfred E. Buxton, M.D.
◆◆
Ott P, Kirk MM, Koo C, He DS, Bhattacharya B,
Buxton A. Coronary sinus and fossa ovalis ablation:
Effect on interatrial conduction and atrial fibrillation.
J Cardiovasc Electrophysiol. 2007;18:310–317.
◆◆
Buxton AE, Lee KL, Hafley GE, Pires LA, Fisher
JD, Gold MR, Josephson ME, Lehmann MH,
Prystowsky EN, the MUSTT Investigators.
Limitations of ejection fraction for prediction of
sudden death risk in patients with coronary artery
disease. J Am Coll Cardiol 2007;50:1150–1157.
◆◆
Piccini JP, Hafley GE, Lee KL, Fisher JD,
Josephson ME, Prystowsky EN, Buxton AE, for
the MUSTT Investigators. Mode of Induction
of Ventricular Tachycardia and Prognosis in
Patients with Coronary Disease: The Multicenter
UnSustained Tachycardia Trial (MUSTT). J
Cardiovasc Electrophysiol; 2009; 20:850–855.
Schol arly Activities
◆◆
Cerqueira MD, Arrighi JA, Geiser EA. Physician
certification in cardiology imaging: Rationale, process,
and benefits. J Am Coll Cardiol Img 2008;1:801–808.
Michael K. Atalay, M.D., Ph.D.
Honors And Awards
◆◆
Abbott JD, Voss MR, Nakamura M, Cohen HA,
Selzer F, Kip KE, Vlachos HA, Wilensky RL,
Williams D.O.. Unrestricted Use of Drug Eluting
Stents Compared to Bare Metal Stents in Routine
Clinical Practice: Findings from the NHLBI Dynamic
Registry. J Am Coll Cardiol 2007;50, 2029–2036.
Bum-Rak Choi, M.D.
◆◆
Ziv O, Morales E, Song Y-K, Peng X, Odening
K, Buxton AE, Karma A, Koren G, Choi
BR. Origin of Complex Behavior of Spatially
Discordant Alternans in Transgenic Rabbit
Model of LQT2, Journal of Physiology, 2009
17
cardiology
CARDIOLOGY FELLOWSHIP PROGRAMS July 1, 2007 – June 30, 2009
GENERAL CARDIOLOGY
James Arrighi, M.D., Director
Peter Tilkemeier, M.D., Associate Director
Name
Medical School
Residency
Kamel Addo, M.D.
Adam Chodosh, M.D.
Wing Kin Fung, M.D.
David Glassman, M.D.
Rahool Karnik, M.D.
Robert Kirchner, M.D.
Craig McMackin, M.D.
Brad Mikaelian, M.D.
Stephan Muhlebach, M.D.
Richard Regnante, M.D.
Aaron Weisbord, M.D.
Ryan Zuzek, M.D.
Brown-Dartmouth Medical Program
Albert Einstein School of Medicine
Tufts University School of Medicine
Indiana University
Tufts University School of Medicine
MCP/Hahnemann School of Medicine
Temple University Medical Center
Loyola University
University of Connecticut-Farmington
MCP/Hahnemann School of Medicine
University of California – Los Angeles
National University of Galway, Ireland
Rhode Island & The Miriam Hospitals
University of Vermont – Fletcher Allen
Tufts University/New England Medical Center
University of Iowa
University of California/Davis Medical Center
David Grant USAF Medical Center
Boston Medical Center
Boston Medical Center
Rhode Island & The Miriam Hospitals
Rhode Island & The Miriam Hospitals
Beth Israel/Deaconess
Cleveland Clinic
ELECTROPHYSIOLOGY
Alfred Buxton, M.D., Director
NameMedical SchoolResidency
Soufian Almahameed, M.D.
David Glassman, M.D.
Brad Mikaelian, M.D.
Ovad Ziv, M.D.
Damascus University
Indiana University
Loyola University
University of Pittsburgh School of Medicine
Cleveland Clinic
University of Iowa
Boston Medical Center
Columbia Presbyterian Hospital
INTERVENTIONAL CARDIOLOGY - Rhode Island Hospital
J. Dawn Abbott, M.D., Director
NameMedical SchoolResidency
Drew Baldwin, M.D.
Timothy Moore, M.D.
Kedar Vaidya, M.D.
Anant Vayas, M.D.
Tulane Medical School
Texas Tech University School of Medicine
Armed Forces Medical College, India
Pramukhswami Medical Center, India
NYU School of Medicine/Bellevue Hospital
Yale/New Haven Hospital
Montefiore Medical Center
Rochester General Hospital
INTERVENTIONAL CARDIOLOGY - The Miriam Hospital
Paul Gordon, M.D., Director
NameMedical SchoolResidency
Mohamad T. Alahdab, M.D.
Russell Linsky, M.D.
Richard Regnante, M.D.
Steven Weinsier, M.D.
18
Damascus University, Syria
University of Arkansas for Medical Sciences
MCP/Hahnemann School of Medicine
University of Alabama, Birmingham
St. Louis University Hospital & VAMC
University of Arkansas for Medical Science
Rhode Island & The Miriam Hospitals
University of Maryland Medical Center
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
POST GRADUATE PLANS
GENERAL CARDIOLOGY
Name
Year GraduatedPost Graduate Plans
Kamel Addo, M.D.
Adam Chodosh, M.D.
Wing Kin Fung, M.D.
David Glassman, M.D.
Rahool Karnick, M.D.
Robert Kirchner, M.D.
Craig McMackin, M.D.
Brad Mikaelian, M.D.
Stephan Muhlebach, M.D.
Richard Regnante, M.D.
Aaron Weisbord, M.D.
Ryan Zuzek, M.D.
2009
2009
2008
2008
2009
2009
2008
2008
2009
2008
2008
2009
Electrophysiology Fellowship - RIH
Electrophysiology Fellowship - RIH
Private Practice in Massachusetts
Electrophysiology Fellowship - RIH
Private Practice in Arizona
Interventional Cardiology Fellowship – RIH/TMH
Private Practice in New Jersey
Electrophysiology Fellowship - RIH
Private Practice in Massachusetts
Interventional Cardiology Fellowship - TMH
Private Practice in Rhode Island
Interventional Cardiology Fellowship – RIH/TMH
ELECTROPHYSIOLOGY
Name
Year GraduatedPost-Graduate Plans
Soufian Almahameed, M.D.
2009
David Glassman, M.D.
2009
Brad Mikaelian, M.D.
2009
Ohad Ziv, M.D.
2008
Academic Electrophysiology – Virginia Tech
Carilion School of Medicine and ResearchInstitute
Private Practice in Kentucky
Private Practice in Colorado
Research Fellow in Electrophysiology – Brown University
INTERVENTIONAL CARDIOLOGY – Rhode Island Hospital
Name
Year GraduatedPost-Graduate Plans
Drew Baldwin, M.D.
Timothy Moore, M.D.
Kedar Vaidya, M.D.
Anant Vayas, M.D 2008
2009
2008
2009
Academic Interventional Cardiology – Tulane Medical Center
Private Practice in California
Interventional Cardiology – Tomball Regional Medical Center
Private Practice in California
INTERVENTIONAL CARDIOLOGY – The Miriam Hospital
Name
Year GraduatedPost-Graduate Plans
Mohamad T. Alahdab, M.D.
Russell Linsky, M.D.
Richard Regnante, M.D.
Steven Weinsier, M.D.
2009
2008
2009
2008
S ELEC T ED P U B LICAT ION S
Private Practice in Illinois
Private Practice in Colorado
Private Practice in Rhode Island
Private Practice in Massachusetts
◆◆
Simon, Aaron, Harrington, Elizabeth, Liu,
GongXin, Koren, Gideon, Choudhary, Gaurav
Mechanism of C-type Natriuretic Peptide-Induced
Endothelial Cell Hyperpolarization. American
Journal of Physiology - Lung Cellular and
Molecular Physiology. 2009 Feb;296(2):L248–56.
◆◆
Choudhary, Gaurav, Aliste, Marcela, Tielman, Peter,
French, Robert J, Dudley, Samuel C. Docking
of Conotoxin GIIIA in Voltage-gated Sodium
Channel.. Channels, 2007 Sep-Oct; 1(5):344–352
C o nti n u e d
Gaurav Choudhary, M.D.
◆◆
Simon, Aaron, Liu, Gong-Xin, Koren, Gideon,
Choudhary, Gaurav cANF Causes Endothelial
Cell Hyperpolarization By Activation of
Chloride Channels. Peptides. 2009. In Press.
19
cardiology
Kristin Ellison, M.D.
◆◆
Frain BH, Ellison KE, Michaud, GF, Koo
CH, Buxton AE, Kirk MM. True bipolar
defibrillator leads have increased sensing latency
and threshold compared with the integrated
bipolar configuration. J Cardiovasc Electrophysiol.
18(2):192–5, Feb 2007/Epub Jan 9, 2007
◆◆
Stanchina ML, Ellison K, Malhotra A, Anderson M,
Kirk M, Benser ME, Tosi C, Carlisle C, Millman RP,
Buxton A. The impact of cardiac resynchronization
therapy on obstructive sleep apnea in hart failure
patients: a pilot study. Chest. 2007;132:433–9.
Ulrike Mende, M.D.
◆◆
Athena Poppas, M.D.
◆◆
Poppas A, Cummings J, Dorbala S Douglas PS,
Poster E, Limacher MC. Survey results: a decade
of change in professional life in cardiology: a
2008 report of the ACC women in cardiology
council. JACC 52(25) 2215–26, 2008.
◆◆
Hoth, K.F., Poppas, A., Moser, D.J., Paul,
R.H., Cohen, R.A. Cardiac dysfunction and
cognition in older adults with heart failure. Cogn Behav Neurol. 21(2):65–72, 2008.
Gideon Koren, M.D.
◆◆
◆◆
◆◆
Brunner M, Peng X, Liu G, Ren X, Ziv O, Choi
BR, Mathur R, Hajjiri M, Odening KE, Steinberg
E, Folco EJ, Pringa E, Centracchio J, Macharzina
RR, Donahay T, Schofield L, Rana N, Kirk
M, Mitchell G, Poppas A, Zehender M, Koren
G. Mechanisms of cardiac arrhythmias and
sudden death in transgenic rabbits with long QT
syndrome. J Clin. Invest. 2008; 118:2246–2259.
Jindal HK, Folco E, Liu G, Koren G. Posttranslational
modification of voltage-dependent potassium
channel Kv1.5: COOH-terminal palmitoylation
modulates its biological properties. Am J Physiol
Heart Circ Physiol 2008; 294:2012-2021.
K.E. Odening, O. Hyder, L. Chaves, L. Schofield, M.
Brunner, M. Kirk, M. Zehender, X. Peng, G. Koren.
Pharmacogenomics of Anesthetic Drugs in Transgenic
LQT1 and LQT2 Rabbits Reveal Genotype-Specific
Differential Effects on Cardiac Repolarization. Am J
Physiol Heart Circ Physiol, 2008; 295: H2264–H2272.
Karim Roder, Ph.D.
◆◆
Roder K., Zhang L., Schweizer M. SREBP1c-mediates the retinoid-dependent increase
in fatty acid synthase promoter activity in
HepG2. FEBS Lett 2007; 581: 2715–2720.
◆◆
Roder K. Overexpressed Drosophila DNA
methyltransferase 2 isoform C interacts with Hsp70
in vivo. J. Biochem Mol Biol 2007; 40: 554–561.
Peter Tikemeier, M.D.
◆◆
Gongxin Liu, M.D., Ph.D
◆◆
◆◆
◆◆
20
Liu GX, Zhou J, Koren G. Single-channel
properties of IK,slow1 and IK,slow2 in mouse ventricular
myocytes. Pflugers Arch. 2008 Jun;456(3):541–7.
Brunner M, Peng X, Liu GX (co-first author), Ren
XQ, Ziv O, Choi BR, Mathur R, Hajjiri M, Odening
KE, Steinberg E, Folco EJ, Pringa E, Centracchio
J, Macharzina RR, Donahay T, Schofield L, Rana
N, Kirk M, Mitchell GF, Poppas A, Zehender M,
Koren G.. Mechanisms of cardiac arrhythmias and
sudden death in transgenic rabbits with long QT
syndrome. J Clin Invest. 2008 Jun;118(6):2246–59.
Liu GX, Vepa S, Artman M, Coetzee WA.
Modulation of Human Cardiovascular Outward
Rectifying Chloride Channel by Intra- and
Extracellular ATP. Am J Physiol Heart Circ
Physiol 2007 Dec;293(6) H3471–H3479.
Zhu M, Gach A, Liu GX, Xu X, Lim CC, Zhang
JX, Mao L, Chuprun K, Koch WJ, Liao R, Koren
G, Blaxall BC, Mende U. Enhanced calcium
cycling and contractile function in transgenic hearts
expressing constitutively active Gao protein. Am J
Physiol Heart Circ Physiol 2008; 294: H1335–H1347.
Tilkemeier PL, Cooke CD, Grossman GB,
McCallister BD, Ward RP. ASNC Imaging
Guidelines for Nuclear Cardiology Procedures: Standardized reporting of radionuclide
myocardial perfusion and function. Journal
of Nuclear Cardiology. Published online: (doi:10.1007/s12350-009-9095-8), 2009
Wen-Chih Wu, M.D.
◆◆
Wu WC, Schiffter TL, Henderson WG, Eaton CB,
Poses RM, Uttley G, Sharma SC, Vezeridis M, Khuri
SF, Friedmann PD. Levels of Preoperative Hematocrit
Predict Postoperative Cardiovascular and Fatal
Outcomes in Elderly Patients Undergoing Major
Non-Cardiac Surgery. J.A.M.A. 2007; 297(22): 2481–8.
◆◆
Pirraglia PA, Taveira TH, Cohen LB, Wu
WC. The moderating effect of depression
diagnosis on the effectiveness of a multi-factorial
cardiovascular risk reduction clinic. Preventing
Chronic Disease 2008; 5(4): A127 pp1–7
◆◆
Khatana SA, Taveira TH, Miner M, Eaton CB, Wu
WC. Does Cardiovascular Risk Reduction Alleviate
Erectile Dysfunction in Men with Type 2 Diabetes
Mellitus? Int J Impot Res. 2008; 20(5): 501–6.
a c a d e m i c y e a r s 20 08 a n d 20 09
RESEARCH
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$2,122,909
$2,219,701
$405,082
$385,505
$2,527,991
$2,605,206
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$830,907
$810,770
$150,604
$117,036
$981,511
$927,806
S ELEC T ED
B A S IC RE S EARCH
S ELEC T ED
CLINICAL RE S EARCH
Guarav Choudhary, M.D.
J. Dawn Abbott, M.D.
◆◆
Role of C-Type Natriuretic Peptide in Pulmonary
Vascular Function, Rhode Island Foundation
◆◆
Role of C-Type Natriuretic Peptide in
Microvascular Endothelial Cell Proliferation
and Apoptosis, Rhode Island – INBRE
◆◆
Role of C-Type Natriuretic Peptide in
Pulmonary Endothelial Function, ATS
◆◆
The Role of Dynamic Changes in Repolarization
and Calcium Transients in Long QT Rabbits,
National Heart Lung & Blood Institute
Gideon Koren, M.D.
◆◆
Brown Cardiopulmonary Research Training Program
(T-32), National Heart Lung & Blood Institute
◆◆
Sex Hormones in Cardiac Arrhythmia in Transgenic
LQT Rabbits, National Heart Lung & Blood Institute
◆◆
Assembly and Trafficking of Cardiac K+ Channels,
National Heart Lung & Blood Institute
◆◆
Heart and Muscle K+ Channels : Assembly and
Regulation, National Heart Lung & Blood Institute
◆◆
G Protein-mediated Signaling and its
Regulation by RGS proteins in Cardiac
Fibroblasts, American Heart Association
◆◆
RGS Regulation of Cardiac Signaling and
Hypertrophy, National Heart Lung & Blood Institute
Structure Function Relations Underlying
Ventricular Tachycardia as Revealed by Cardiac
MRI, Rhode Island Medical Imaging
Daniel Levine, M.D.
◆◆
Delay in Heart Failure (Subcontract),
University of Massachusetts/NHLBI
Barry Sharaf, M.D.
◆◆
E-WISE (subcontract), University of
Florida, Gainesville/NHLBI
◆◆
Freedom (subcontract), Mount Sinai/NHLBI
Satish Sharma, M.D.
◆◆
The Home INR Study (THINRS),
Veterans Administration
Wen-Chih Wu, M.D.
◆◆
Combined Behavioral & Pharmacological
Intervention for Cardiac Risk Reduction in
Diabetic Patients, Rhode Island Foundation
◆◆
Multi-Targeted Cardiac Risk Intervention in
Type 2 Diabetes, Dougherty Foundation
◆◆
Group Intervention for DM Guideline
Implementation, Veterans Administration
Ulrike Mende, M.D.
◆◆
Determination of Non-Responsiveness to
Anti-Platelet Therapy in Patients Undergoing
Percutaneous Coronary Intervention using a
Point-of-care Device, Rhode Island Foundation
Alfred E. Buxton, M.D.
Endothelial BKCa Channels and Hypoxic Pulmonary
Endothelial Dysfunction, Veterans Administration
Bum-Rak Choi, M.D.
◆◆
◆◆
Katja Odening, M.D.
◆◆
Estrogen Arrythmia Fellowship,
American Heart Association
Ohad Ziv, M.D.
◆◆
VF in Different Subs Fellowship,
American Heart Association
21
endocrinology
DIVI S ION OF
ENDOCRINOLOGY
OVERVIE W
T
he Division of Endocrinology at the Warren Alpert Medical School of Brown University includes
the Hallett Center for Diabetes and Endocrinology, an outpatient Clinical Research Unit, and the
Diabetes and Endocrinology Research Laboratories. The
Division coordinates academic and clinical programs at
Rhode Island Hospital, The Miriam Hospital, the Providence Veterans Administration Medical Center and the
Roger Williams Medical Center. The Division provides
consult services and manages a Bone Density Unit with
state-of-the art diagnostic and osteoporosis management
capabilities at Women and Infants Hospital, includes
affiliated faculty at Memorial Hospital of Rhode Island,
and integrates educational activities with the Division of
Pediatric Endocrinology.
The Hallett Center was created in 2001 as a comprehensive, academic diabetes and endocrinology program. Patient care at the Hallett Center is provided by six boardcertified endocrinologists, all of whom have Brown
University faculty appointments. The Center currently
accommodates more than 10,000 patient visits per year
and is continuing to expand its services. To assure readily
accessible, comprehensive care for patients with diabetes,
specialty services are offered within the Center not only
in diabetes and endocrinology, but also in nephrology, podiatry, and nutrition/weight management. In
addition, outpatient programs of the Hasbro Children’s
Hospital in pediatric diabetes and endocrinology are
conducted in the Hallett Center facility. Quality of care
measures at the Hallett Center markedly exceed national
performance levels and standards. The Hallett patient
education program has been awarded multi-site center
certification status by the American Diabetes Association.
Through a program developed cooperatively with the
Rhode Island Department of Health, the Hallett Center
certification status extends to multiple satellite patient
education units throughout the state of Rhode Island.
Laboratory research programs in the Division of Endocrinology include the programs of four groups. Dr.
Robert J. Smith, the division director is investigating
insulin and insulin-like growth factor signaling mechanisms and their roles in the molecular causes of diabetes,
22
Robert J. Smith, Professor of Medicine
Director, Division of Endocrinology and
the Hallett Center for Diabetes and Endocrinology
growth disorders, and neurodegenerative disease. The
laboratory of Eduardo A. Nillni, Ph.D. is studying the
prohormone processing and molecular physiology of
hypothalamic neuropeptides related to energy balance.
Haiyan Xu, M.D., Ph.D., is investigating the role of
adipose tissue in mediating inflammatory responses
that contribute to the complications of obesity and
diabetes. Leslie J. DeGroot, M.D., who was formerly
chief of endocrinology at the University of Chicago and
is a world-renowned researcher on autoimmune causes
of thyroid disease, is working on novel strategies for
blocking thyroid autoimmunity. Robert J. Smith, M.D.
and Geetha Gopalakrishnan, M.D., jointly coordinate
research activities in the Clinical Research Unit, which
involve multiple division faculty members.
The Division of Endocrinology provides extensive teaching in diabetes and endocrinology at Brown University,
The Warren Alpert Medical School, and the affiliated
academic hospitals. The Division faculty members have
been honored by many teaching awards from Brown
University. In addition to a broad range of classroom
and bedside teaching activities, the faculty members
serve as research mentors and thesis advisors to graduate
and postgraduate level trainees, plus undergraduate
independent study students. The educational program includes a nationally recognized, highly selective
ACGME-certified clinical fellowship in Endocrinology,
Diabetes, and Metabolism.
a c a d e m i c y e a r s 20 08 a n d 20 09
F a c u lt y M e mb e r s
◆◆
“New Options for Treating Diabetes”,
PharmEd Continuing Education Programs
for Pharmacists. Hyannis, MA
◆◆
“The Evolving Role of Incretin-Based Therapy in
Managing Type 2 Diabetes”, PharmEd Continuing
Education Programs for Pharmacists. Rocky Hill, CT
(Hospital and Foundation Based)
Associate Professors
Paul Levinson, M.D.
Assistant Professors
Geetha Gopalakrishnan, M.D.
Ivana Lukacova-Zib, M.D.
Haiyan Xu, M.D., Ph.D.
Clinical Faculty
j u ly 1 , 20 07 – j u n e 30 , 20 09
Invited Pr esentations
Full-Time Faculty
Professors
Robert J. Smith, M.D., Director
Leslie J. DeGroot, M.D.
Eduardo A. Nillni, Ph.D.
◆
Eduardo A. Nillni, Ph.D.
Honors And Awards
◆◆
Member, Integrative Physiology of
Obesity and Diabetes Study Section,
Center for Scientific Review, NIH
◆◆
Managing Editor of Frontiers in Bioscience
special issue on Energy Balance Regulation
Invited Pr esentations
◆◆
“TRH Biology and Energy Balance”,
University of Pennsylvania, PA
Associate Professors
Marc J. Laufgraben, M.D.
◆◆
“Diet Induce Obesity and the Thyroid Axis”,
University of Cambridge, United Kingdom
Assistant Professors
Dominic Corrigan, M.D.
◆◆
“Hypothalamic Endoplasmic Reticulum Stress
Alters POMC Processing and Contributes
to Leptin Resistance”, Tel Aviv, Israel
(Hospital and Foundation Based)
Volunteer Clinical Faculty
Associate Professors
Charles Eil, M.D., Ph.D.
Assistant Professors
Robert Dobrzynski, M.D.
Roberto Ortiz, M.D.
Valerie Thomas, M.D.
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Geetha Gopalakrishnan, M.D.
Robert J. Smith, M.D
Honors And Awards
◆◆
Taft Honorary Lectureship of the
Endocrine Society of Australia
◆◆
Honorary Professor, Luzhou Medical
University, Luzhou, China
◆◆
Honorary President of The Affiliated Hospital of
Luzhou Medical, University, Luzhou, China
Invited Pr esentations
◆◆
Invited Speaker, GeNeSIS Investigators
Meeting, Paris, France
◆◆
Plenary Lecturer, Joint Endocrine Society of
Australia and New Zealand Society of Endocrinology
Clinical Weekend, Christchurch, New Zealand
◆◆
Honorary Taft Plenary Lecturer, Endocrine Society
of Australia and Endocrine Society of New Zealand
Annual Scientific Meeting, Christchurch, New Zealand
◆◆
Invited Symposium Lecturer, Endocrine Society of
Australia and Endocrine Society of New Zealand
Annual Scientific Meeting, Christchurch, New Zealand
◆◆
Chair and Speaker, International Symposium
on Progress in Diabetes, The Affiliated Hospital
of Luzhou Medical University, Luzhou, China
Honors And Awards
◆◆
Best Doctor, Better Living Magazine, 2008
◆◆
Chairman, National Osteoporosis
Foundation Advocacy
◆◆
Certificate of Recognition for Exemplary
Teaching, Warren Alpert MedicalSchool
of Brown University, 2009
Marc J. Laufgraben, M.D.
Honors And Awards
◆◆
Socioeconomic and Member Advocacy Committee,
American Association of Clinical Endocrinologists
◆◆
Invited Seminar Speaker, Chongqing
Medical University, Chongqing, China
◆◆
Beckwith Family Award for Outstanding Teaching,
Alpert Medical School of Brown University, 2009
◆◆
Invited Seminar Speaker, Beijing Medical
University, Beijing, China
23
endocrinology
Haiyan Xu, M.D., Ph.D.
◆◆
Invited Pr esentations
◆◆
“Obesity and Adipose Inflammation: Role
of Infiltrated Macrophages”, Chongqing
Medical University, Chongqing, China
◆◆
“Obesity and Adipose Inflammation: Role of
Infiltrated Macrophages”, Peking University,
Health Science Center, Beijing, China
◆◆
Eduardo A. Nillni, Ph.D.
◆◆
Perello M, Stuart RC, and Nillni EA. ProThyrotropin
Releasing Hormone (proTRH) targets its
processing products to different vesicles of
the secretory pathway. J Biol Chem. 2008 Jul
18;283(29):19936–47. Epub 2008 May 12
◆◆
Bousquet-Moore D, Ma XM, Nillni EA, Czyzyk
TA, Pintar JE, Eipper BA, Mains RE. Reversal
of physiological deficits caused by diminished
levels of peptidylglycine alpha- amidating
monooxygenase by dietary copper. Endocrinology.
2009 Apr;150(4):1739–47. Epub 2008 Nov 20.
“Adipose Inflammation and Obesity” AGA Institute
at Digestive Disease Week 2008, San Diego, CA
s e l e c t e d P U B LICAT ION S
Geetha Gopalakrishnan, M.D.
◆◆
Phillips BD, Gopalakrishnan G, Gohh R, Hennessey
JV. Lithium toxicity precipitated by profound
hypothyroidsm. Thyroid. Jun 2008;18(6)651–4.
◆◆
Pan D, Shin YH, Gopalakrishnan G, Hennessey
JV, DeGroot LJ. Regulatory T cells in Graves’
disease. Clinical Endocrinology. Feb 2009.
Robert J. Smith, M.D.
◆◆
Ling PR, Smith RJ, Bistrian BR. Acute effects of
hyperglycemia and hyperinsulinemia on hepatic
oxidative stress and the systemic inflammatory
response in rats. Crit Care Med. 2007; 35: 555–600.
◆◆
Smith RJ, McLean M. Managing high blood glucose
levels in coronary care. Int Med J 2008; 38: 305–306.
Marc J. Laufgraben, M.D.
◆◆
◆◆
Mayrin JV, Donahue JE, Laufgraben MJ.
Visual Vignette: Prolactinoma, before and
after treatment with dopamine agonist.
Endocrine Practice 2008;14:256.
Phillips BD, Laufgraben MJ. Diabetic Muscle
Infarction in a 28-Year Old Woman: Case
Report and Review of the Literature. The
Endocrinologist 2008;18:187–190.
Phillips BD, Phornphutkul C, Laufgraben
MJ. A Novel Mutation of the Succinate
Dehydrogenase D Gene in a Patient with
Recurrent Pheochromocytoma and Paraganglioma.
The Endocrinologist 2008;18:241–244.
Haiyan Xu, M.D., Ph.D.
◆◆
Xu H (corresponding author), Wilcox D, Phong
N, Voorbach M, Smith H, Suhar T, Reilly R,
Jacobson P, Collins C, Landschulz K, Surowy T.
Hepatic knockdown of stearoyl-CoA desaturase
1 via RNA interference in obese mice decreases
lipid content and changes fatty acid composition.
Front Biosci 2007; 12:3781–3794. 2007.
ENDOCRINOLOGY FELLOWSHIP PROGRAM
Geetha Gopalakrishnan, M.D., Director of Fellowship Program
Graduates 2008
FellowMedical School/ResidencyPost-Fellowship Position
Jane Mayrin
Drexel University College of Medicine
Academic Practice in Philadelphia, PA
Thomas Jefferson Medical College
Brian Phillips
UM.D.NJ Robert Wood Johnson
Private Practice in Massachusetts
Alpert Medical School of Brown University
Graduates 2009
FellowMedical School/ResidencyPost-Fellowship Position
Heath Meattey
Tulane University School of Medicine
Private Practice in New Hampshire
BI Deaconess Medical Center
Hilary Whitlatch
Tufts University School of Medicine
Division of Endocrinology,
BI Deaconess Medical Center
Alpert Medical School of Brown University,
Rhode Island Hospital/VA Medical Center
24
a c a d e m i c y e a r s 20 08 a n d 20 09
RESEARCH
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$555,835
$668,078
$103,183
$126,443
$659,018
$794,521
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$69,213
$68,725
$15,680
$7,127
$84,893
$75,852
S ELEC T ED
B A S IC RE S EARCH
S ELEC T ED
CLINICAL RE S EARCH
Leslie J. DeGroot, M.D.
Robert J. Smith, M.D.
◆◆
Pathogenesis and Therapy of Autoimmune
Thyroid Disease, National Institute of
Diabetes and Digestive Diseases
◆◆
Immune System Modulation to Treat
and Prevent Type 1 Diabetes, Epivax, Inc/
Juvenile Diabetes Association
Eduardo A. Nillni, Ph.D.
◆◆
ProTRH gene transcription and biosynthesis by leptin,
National Institute of Diabetes and Digestive Diseases.
◆◆
ProTRH Gene Transcription and Biosynthesis by
Leptin, National Institutes of Health/Yale University.
Haiyan Xu, M.D., Ph.D.
◆◆
Mechanism and consequence of obesity-related
adipose macrophage infiltration, American Heart
Association Scientist Development Grant.
◆◆
MAP kinase phosphatase 3 and obesityrelated gluconeogenesis, National Institute
of Diabetes and Digestive Diseases
◆◆
MAP Kinase Phosphatase 3 (MKP3) and Obesity
Related Gluconcogenes (ARRA Supplement),
National Institute of Diabetes and Digestive Diseases
◆◆
The mechanism of MAP kinase phosphatase 3
(MKP-3) induced gluconeogenesis in obesity
and diabetes, Charles H. Hood Foundation
25
g a s t r o e n t e r o l o g y a n d h e pat o l o g y
Division of
G astroen tero logy
a n d H e pato lo gy
OVERVIE W
T
he Division of Gastroenterology and Hepatology
at Brown University extends to Rhode Island,
Miriam, Women and Infants, and Veteran’s
Administration Hospital(s). The major missions of the
Division are to provide state-of-the-art treatment to
those with gastrointestinal and liver diseases; to educate
undergraduates, medical students/residents, postdoctoral fellows in the pathophysiology of digestive diseases,
and to engage in “cutting-edge” basic and applied
research. The Rhode Island Hospital Endoscopy Suite
is equipped with the latest technological advances, and
accommodates consultations from Southeastern Massachusetts, Cape Cod, Connecticut, and Rhode Island.
The Liver Research Center, and Swallowing/Motility Research Center are located on the Rhode Island Hospital
campus, and are staffed with twelve principal investigators, twenty-five postgraduate physician/scientists, and
twenty undergraduate/graduate students providing a
strong basic science program to advance the understanding of disease processes at the cellular and molecular
level. N.I.H. sponsored projects include: motility and
signal transduction of the G.I. tract, H. pylori in gastric
cancer, pathogenesis of NASH, molecular mechanisms
of hepatic fibrosis, antiviral approaches to hepatitis
B and C infection, molecular pathogenesis of human
hepatocellular carcinoma, and monoclonal antibodies in
the treatment of G.I. malignancy.
RE S EARCH
Faculty in the Division of Gastroenterology and
Hepatology hold varied N.I.H., N.S.F., corporate,
foundation, and pharmaceutical grants to support
basic and translational research activities. Fifty faculty
publications appeared in highly respected, peer-review
journals in the past year.
T EACHING
The Brown University Fellowship Program in Gastroenterology is a three-year A.C.G.M.E./A.B.I.M. accredited
program conducted by thirteen fulltime and twenty-seven volunteer faculty stationed at the Rhode Island, Miriam, Women and Infants, and Veteran’s Administration
26
Jack R. Wands, M.D., Jeffrey and Kimberly Greenberg-Artemis and Martha
Joukowsky Professor in Gastroenterology and Professor of Medical Science;
Director, Division of Gastroentoerology and Liver Research Center
Hospital(s). Individuals are encouraged to select the
Clinical-Scholar, Physician-Scientist, or Research track;
mentors of varied interests are on-site to assist Fellows
allowing a unique clinical/research perspective.
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Jack R. Wands, M.D., Director - Tenured
Jose Behar, M.D.
Piero Biancani, Ph.D.
Suzanne de la Monte, M.D., M.P.H.
Steven F. Moss, M.D., Program Director
Associate Professors
Ji-Su Li, M.D., Ph.D.
Harlan Rich, M.D.
Shuping Tong, M.D., Ph.D.
Assistant Professors
Weibiao Cao, M.D.
Fadlallah Habr, M.D.
Karen Harnett, Ph.D.
Miran Kim, Ph.D
Kittichai Promrat, M.D.
a c a d e m i c y e a r s 20 08 a n d 20 09
Clinical Faculty
◆◆
(Hospital and Foundation Based)
Associate Professors
Silvia Degli-Esposti, M.D.
Assistant Professors
Thomas D. DeNucci, M.D.
Hatem Shoukeir, M.D.
Instructors
Jeanette Smith, M.D.
◆
Member, NIH NIDDK Special Emphasis
Panel for Neuromuscular GI Projects, 2008
Invited pr esentations
◆◆
International Symposium on O.E.S.O.,
Monaco, France, 2008
◆◆
Chair: GERD: from reflux to mucosal inflammation
◆◆
Organ Smooth Muscle: development, physiology
and pathology symposium - Bethesda, M.D. 2009
◆◆
Speaker: Inflammation and signaling
in the development of esophagitis
Volunteer Clinical Faculty
Suzanne de la Monte, M.D., M.P.H.
Associate Professors
Nicholas Califano, M.D.
Neil Greenspan, M.D.
Daniel M. Quirk, M.D., M.Ph.
Thomas Sepe, M.D.
Samir A. Shah, M.D.
Honors And Awards
Assistant Professors
Alyn Adrain, M.D.
Paul Akerman, M.D.
Bret Ankowitz, M.D.
Christy L. Dibble, D.O.
Brett Kalmonwitz, M.D.
Sheldon Lidofsky, M.D.
Peter Margolis, M.D.
Jay Sorgman, M.D.
Jeremy Spector, M.D.
Joel S. Spellun, M.D.
Paul vanZuiden, M.D.
Instructors
Leslie Cashel, M.D.
David Schreiber, M.D.
◆◆
Senior Associate Editor, Journal Alzheimer’s Disease
◆◆
IACUC Committee Member, Lifespan
Invited Pr esentations
◆◆
Speaker: Role of peripheral and brain insulin resistance in
neurodegeneration, 22nd Biennial Meeting, International
Society of Neurochemistry, Busan, So Korea 2009
◆◆
Speaker: Insulin resistance, cognitive impairment
and neurodegeneration, CSCN-CSS
C0nference, Quebec City, Canada 2009
◆◆
Speaker: Insulin resistance and neurodegeneration:
type 2 vs type 3 diabetes mellitus, NY
Academy of Sciences, NY, NY 2009
Schol arly Activities
◆◆
Fellow, American Gastroenterological
Association 2009
Invited Pr esentations
◆◆
Participant , Boston International Live Therapeutic
Endoscopy Course, Oct 07 and Oct 08
◆◆
Guest Lecturer, Use of narrow band imaging during
cryotherapy performed for ablation of Barrett’s
esophagus with high-grade dysplasia, National
web-based seminar on cryotherapy in the
palliation of esophageal cancer, September 08
Karen Harnett, Ph.D
Honors And Awards
◆◆
Invited pr esentations
◆◆
Guest Lecturer- 9th World Congress Meeting: Gastroesophageal reflux disease from reflux to inflammation
to adenocarcinoma, April 2008, Monaco, France.
Piero Biancani, Ph.D
NAL NIH Study Section Member 2007
Fadlallah Habr, M.D.
Jose Behar, M.D.
◆◆
Editorial Board, Cellular and Molecular Life Sciences
◆◆
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Honors And Awards
j u ly 1 , 20 07 – j u n e 30 , 20 09
Editorial Board, The American Journal of
Physiology: Gastrointestinal and Liver Physiology
Invited Pr esentations
◆◆
Presenter: Neural and non-neural norceptors
present in the esophageal mucosa, OESO
9th World Congress, Monaco 2008
Honors And Awards
◆◆
Member, International Organization for the
Study of Esophageal Diseases,1994–present
27
g a s t r o e n t e r o l o g y a n d h e pat o l o g y
◆◆
Visiting Professor Lectureship: Interpreting
pharmacokinetic studies and designing dosage
regimens and dose interpreting pharmacokinetic
studies and designing dosage regimens, Boston
University School of Medicine 2007, 2008, 2009.
Miran Kim, Ph.D
Invited Pr esentations
◆◆
Lecturer: Activation of the beta-catenin pathway in
human HCC mediated by Wnt3 and FD7 receptor
interaction, International Meeting of the Wnt
Signaling in Development and Disease, Germany 2007
◆◆
Lecturer: Alterations of signaling pathways in
hepatocarcinogenesis, International Symposium
on Digestive Disease, Seoul, Korea 2008
◆◆
Lecturer: Wnt signaling in hepatocellular
carcinoma, International Symposium on
Digestive Disease, Seoul, Korea 2008
Ji-Su Li, M.D., Ph.D
Honors And Awards
◆◆
Editorial Board, Laboratory Investigation
◆◆
Editorial Board, Journal of Infectious Diseases
◆◆
Editorial Board, Journal of Virological Methods
Invited Pr esentations
◆◆
Presenter: Cleavage of duck hepatitis B virus envelope
protein by furin/PC7 like-convertases promotes
viral cccDNA formation in non-susceptible LMH
cells, International Meeting of the Molecular
Biology of HBV Viruses, San Diego, CA
Steven F. Moss, M.D.
◆◆
NIH Study Section: NCI PO1 - Jun 08
◆◆
NIH Study Section: NCI PO1 - Jan 09
◆◆
NIH Study Section: NIDDK
Challenge grants – Jun 09
Kittichai Promrat, M.D.
Invited Pr esentation
◆◆
Randomized controlled trial testing the effects
of weight loss on nonalcoholic steatohepatitis.
American Association for the Study of Liver
Disease , San Francisco, CA 2008
◆◆
Meet the Professor - Managing Co-morbidities
in NASH 2008, American Gastroenterological
Association, Washington, DC 2009
◆◆
Co-moderator: Approaches to weight loss in NASH;
when and how aggressive? American Association for the
Study of Liver Disease Clinical Symposium- 2009
Schol arly Activities
◆◆
GI Clinical Champion, National VA
Colorectal Cancer Care Collaborative
◆◆
Member, NIDDK Safety Monitoring
Committee RO1 DK 068598-01A1
◆◆
Member, Review Panel Committee: The Dr. George
A Bray Research Scholars Award Fund 2008
Hatem Shoukeir, M.D.
Invited Pr esentations
◆◆
A case of gastric outlet obstruction after migration and
fracture of an esophageal stent. American College
of Gastroenterology, San Diego, CA 2009
◆◆
A case report of concomitant acute autoimmune
pancreatitis and fulminant autoimmune
hepatitis in a young male. American College
of Gastroenterology, San Diego, CA 2009
Honors And Awards
◆◆
American Gastroenterology Fellow ◆◆
Editorial Board, American J Gastroenterol
Invited Pr esentations
◆◆
◆◆
Invited Member: World Health OrganizationInternational Agency for Cancer ResearchMonograph 100 “Evaluation of Carcinogenic Risks
to Humans of Biological Agents.” Lyon, France
Invited Speaker: H. Pylori treatment and
diagnosis: focused clinical update. American
Gastroenterology Association
Shuping Tong, M.D.
Honors And Awards
◆◆
Editorial Board, Journal of Hepatology, 2009
◆◆
Editorial Board, Hepatology
◆◆
Editorial Board, Gastroenterology
Invited Pr esentations
◆◆
Schol arly Activities
28
◆◆
NIH Study Section: NIDDK PO1 Program Project
Site Visit, Mar 07 & Feb 08, K08 review Jul 07
◆◆
NIH/NCI Carcinoid-neuroendocrine
tumors summit. Bethesda M.D. Sep 07
◆◆
NIH Study Section: NIDDK Gastric
Mucosal Pathobiology, Feb 08 (ad hoc)
Speaker: Drug resistant and immune escape
hepatitis B virus mutants. Centers for Disease
Control Symposium, Atlanta, Georgia 2009
Schol arly Activities
◆◆
Member, NIH Virology B Study
Section (Ad Hoc), 2008
a c a d e m i c y e a r s 20 08 a n d 20 09
Jack R. Wands, M.D.
Honors And Awards
◆◆
Editorial Board, International Journal of Oncology
◆◆
Editorial Board, Cancer Therapy
◆◆
Editorial Board, J Hepatology
◆◆
Honorary Professor, Hospital 3021 and the Medical
and Graduate Schools of the PLA, Beijing, China 2007
◆◆
Fellow, American Gastroenterological Association - 2008
Invited Pr esentations
◆◆
Moderator: Postgrad course on Liver Cancer and
Stem Cells, American Association for the Study
of Liver Disease, San Francisco, CA, Oct 2008
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Second Ditan International Symposium on
Infectious Diseases – China, Nov 2008
◆◆
Speaker: “Alcohol Induced Liver Disease” Eighth
Hepatobiliary and GI Research Retreat Vulperia, Switzerland, Jan 2009
Schol arly Activities
◆◆
Member, NIH/NIAAA Center
Grant Review, Jun 2007
◆◆
Moderator, NIH/NCI - PO1 Clinical Studies
Special Emphasis Panel, Feb 2008
◆◆
Member, NIH, Special Emphasis
Panel, Bethesda, M.D., Jul 2008
◆◆
Member, NIH/NCI Intramural Program,
Bethesda, M.D., Sep 2008
GASTROENTEROLOGY FELLOWSHIP PROGRAM
Steven F. Moss, M.D., Program Director
Graduate Fellows
Sumona Saha, M.D.
Deepak Agrawal, M.D.
Randall Pellish, M.D.
Mark Branda, M.D.
Chad Morse, M.D.
Kenneth Shieh, M.D.
Bret Ancowitz, M.D.
2008
2008
2008
2008
2007
2007
2007
Academic GI
Interventional
Clinical GI
Clinical GI
Clinical GI
Clinical GI
Clinical GI
- U Wisc Sch Med
- Cleveland Clinic
- U Mass Med Ctr
- Maine
- Oregon
- Boston, MA
- Providence, RI
Present FellowsMedical SchoolResidency
Joshua Beirne, M.D.
PGY4 SW Med Sch/U Tx
Adam Harris, M.D.
PGY4 Albert Einstein
Mitul Patel, M.D.
PGY4 RW Johnson Med Sch
Amanda Pressman, M.D.
PGY4 Case Western Reserve
Julie Foont, M.D.
PGY5 NYU School Medicine
David Kerstetter, M.D. PGY5 Boston U
Nnenna Okpara, M.D.
PGY6 Columbia
Jeffrey Zaidman, M.D. PGY6 U Virginia
S ELEC T ED P U B LICAT ION S
UCSF
Columbia U Med Ctr
Mnt Sinai, NY
Beth Israel Deaconess
NYU IM Program in Medicine
Brigham & Womens Hospital/
Harvard Med School
Columbia U Med Ctr
U Penn
Suzanne de la Monte, M.D., M.P.H.
◆◆
Cheng L, Pricolo V, Biancani P, Behar J:
Overexpression of progesterone receptor B
increases sensitivity of human colon muscle cells to
progesterone. Am J Physiol 2008;295:G493–G502.
Carter JJ, Tong M, Silbermann E, Lahousse SA, Ding
FF, Longato L, Roper N, Wands JR, de la Monte SM.
Ethanol impaired neuronal migration is associated
with reduced aspartyl-asparaginyl-beta-hydroxylase
expression. Acta Neuropathol 2008; 116:303–15.
◆◆
Cong P, Pricolo V, Biancani P, Behar J: High levels
of caveolar cholesterol inhibit progesterone induced
genomic actions in human and guinea pig gallbladder
muscle. Am J Physiol 2009;296:G948–G954.
De la Monte SM, Yeon JE, Tong M, Longato L,
Chaudhry R, Pang MY, Duan K, Wands JR. Insulin
resistance in experimental alcohol-induced liver
disease. J Gastroenterol Hepatol 2008; 23:477–86.
◆◆
De la Monte SM, Tong M, Cohen AC, Sheedy D,
Harper C, Wands JR. Insulin and insulin-like growth
factor resistance in alcoholic neurodegeneration.
Alcohol Clin Exp Res 2008;32:1630–44.
Jose Behar, M.D.
◆◆
◆◆
29
g a s t r o e n t e r o l o g y a n d h e pat o l o g y
Fadlallah Habr, M.D.
◆◆
Pellish R, Ryder B, Habr F. An unusual complication:
post polypectomy appendicitis. Endoscopy 2007; 39:138.
◆◆
Evans D, Miner T, Iannitti D, Akerman
P, Habr F. Capecitabine and carboplatin in
metastatic esophogastric cancer: a phase II
study. Cancer Invest 2007;25:445–8.
Shuping Tong, M.D.
◆◆
Qin Z, Zhang J, Mao R, Guo H, Wands J, Tong
S. Prevalence of basal core promoter and precore
mutations in Chinese chronic HBV and correlation
with serum HBeAg titers. J Med Virol 2009;81:807–14.
◆◆
Ito K, Kim KH, Lok A, Tong S. Characterization of
genotype-specific carboxy-terminal cleavage sites of
HBV virus e antigen precursor and i9dentification of
furin as the candidate enzyme. J Virol 2009;83:3507–1
◆◆
Tsai A, Kwai S, Kwei K, Gewaily D, Hutter
A, Tong D, Li J, Wands J, Tong S. Chimeric
constructs between two hepatitis B virus genomes
confirm transcriptional impact of core promoter
mutations and reveal multiple effects of core
gene mutations. Virology 2009;387:364–72
Karen Harnett, Ph.D
◆◆
Cheng L, de la Monte SM, Ma J, Hong J,
Tong M, Cao W, Behar J, Biancani P, Harnett
KM: HCL-activated neural and epithelial
Vanilloid receptors (TRPV1) in cat esophageal
mucosa. Am J Physiol 2009;297:G135–G143.
Miran Kim, Ph.D
◆◆
Kim M, Lee HC, Tsedensodnom O, Hartley R, Lim
Y-S, Yu E, Merle P, Wands JR. Activation of Wnt3/
-catenin pathway is mediated by Frizzled-7 receptor in
human hepatoma cells. J Hepatol 2008; 48:780–91.
JiSu Li, M.D., Ph.D
◆◆
Kim E, Li K, Lieu C, Tong S, Kawai S, Li JS
et al. Expression of apolipoprotein C-IV is
regulated by Ku antigen/peroxisome proliferatoractivated receptor g complex and correlates with
liver steatosis. J Hepatol 2008;49:787–98
Steven Moss, M.D.
◆◆
Moss SF, Lee JW, Sabo E, Rubin AK, Rommel
J, Westley B, May FE, Gao J, Meitner P, Tavares
R, Resnick MB. Decreased gastrokine 1 and trefoil
interacting protein TFIZ1/GKH2 in gastric cancer:
influence of tumor histology and relationship to
prognosis. Clin Cancer Res 2008;14:4161–7.
◆◆
Vorlop E, Zaidman J, Moss SF. Clinical challenges
and images in GI: “Downhill” esophageal varices
secondary to superior vena cava occlusion.
Gastroenterology 2008;135:1863–2185.
◆◆
Modlin IM, Hunt RH, Malfertheiner P, Moayyedi P,
Quigley EM, Tytgat GN, Tack J, Holtmann G, Moss
SF. Non-erosive reflux-disease-defining the entity and
delineating the management. Digestion 2008;788:1–5.
Kittichai Promrat, M.D.
◆◆
30
Mallette C, Flynn M, Promrat K. Outcome
of screening for HCV infection in the veteran
population. Am J Gastroenterol 2008;103:131–7.
Jack R. Wands, M.D.
◆◆
Gehring S, Gregory SH, Wintermayer P, Aloman C,
Wands JR. Generation of immune responses against
HCV by dendritic cells containing NS5 protein-coated
microparticles. Clin Vaccine Immunol 2009;16:163–71.
◆◆
Pang M, de la Monte SM, Longato L, Tong
M, He J, Chaudhry R, Duan K, Ouh J, Wands
JR. PPARd agonist attenuates alcohol-induced
hepatic insulin resistance and improves liver
injury and repair. J Hepatol 2009;50:1192–1201.
◆◆
Longato L, de la Monte SM, Kuzushita N,
Horimoto M, Rogers AB, Slagle BL, Wands JR.
Overexpression of insulin receptor substrate-1 and
hepatitis Bx genes cause premalignant alterations
in the liver. Hepatology 2009;49:1935–43.
a c a d e m i c y e a r s 20 08 a n d 20 09
RESEARCH
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$3,486,987
$3,342,516
$1,159,798
$1,060,932
$4,646,735
$4,403,448
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$208,072
$286,047
$63,396
$86,736
$271,468
$372,783
S ELEC T ED
B A S IC RE S EARCH
◆◆
P27 and Apoptosis Resistance in Gastric Cancer
(ARRA Supplement), National Cancer Institute
◆◆
Genome Wide Fine-Mapping of H. Pylori
Stimulated Human T Cell Responses, National
Institute of Allergy and Infectious Diseases
Jose Behar, M.D.
◆◆
Role of Progesterone in Colonic Muscle
Dysfunction, National Institute of Diabetes
Digestive and Kidney Disease
Piero Biancani, Ph.D.
◆◆
Inflammation and Signal Transduction in
Esophagitis, National Institute of Diabetes
Digestive and Kidney Disease
Shuping Tong, M.D., Ph.D.
◆◆
Variant HBV Genomes, American Cancer Society
◆◆
Biomarker for Hepatocellular Carcinoma,
National Cancer Institute
Jack Wands, M.D.
◆◆
Biomarker for Hepatocellular Carcinoma,
National Cancer Institute
◆◆
Pathogenesis, Immunodiagnosis, and Therapy
of HCC, National Cancer Institute
◆◆
Alcohol Effects on the Liver, National Institute
on Alcohol Abuse and Alcoholism
◆◆
HCV in Alcoholics, National Institute
on Alcohol Abuse and Alcoholism
◆◆
Ethanol, IRS-1 Signaling and Neuronal Migration,
National Institute on Alcohol Abuse and Alcoholism
◆◆
Research Training Program in
Gastroenterology, National Institute of
Diabetes Digestive and Kidney Diseases
◆◆
Biomarker for Hepatocellular Carcinoma,
National Cancer Institute
Weibiao Cao, M.D.
◆◆
NADPH Oxidase-Associated Transition from
Barrett’s Esophagus to Adenocarcinoma, National
Institute of Diabetes Digestive and Kidney Diseases
◆◆
COBRE RIH Theme B: Pathogenesis of GI Tumors,
GERD, Esophagitis, National Center for Research
Suzanne De la Monte, M.D.
◆◆
Midcareer Investigator Award in Alcohol
Related Human Disease Research, National
Institute on Alcohol Abuse and Alcoholism
◆◆
Effects of Ethanol on Insulin Signaling on the Brain,
National Institute on Alcohol Abuse and Alcoholism
◆◆
Effects of Ethanol on Insulin Signaling on the Brain
(ARRA Supplement), National Center for Research
◆◆
Placenta and FAS, Women and Infants
Ji-Su Li, M.D., Ph.D.
◆◆
Molecular Targets for Interruption of HBV
Infection, National Cancer Institute
Steven Moss, M.D.
◆◆
P27 and Apoptosis Resistance in Gastric
Cancer, National Cancer Institute
◆◆
Gastric Cancer Induced by H. Pylori in P27
Deficient Mice, National Cancer Institute
◆◆
COBRE RIH Theme B: H. Pylori in Gastric
Carcinogenesis, National Center for Research Resources
S ELEC T ED
CLINICAL RE S EARCH
Samir Shah, M.D.
◆◆
OSCAR, Mass General Hospital/
National Institute of Health
◆◆
Epidemiology of IBV, Mass General Hospital/
National Institute of Health/Centers
for Disease Control and Prevention
31
gener al internal medicine
GENERAL
IN T ERNAL M EDICINE
OVERVIE W
T
he 2007 and 2008 academic years have seen
continued growth, achievement and change
for the Division of General Internal Medicine
(DGIM). After 28 years of outstanding leadership of
the division, Michele G. Cyr M.D. accepted a full-time
position in the Dean’s Office, and now serves as Associate Dean for Academic Affairs. Mark J. Fagan M.D.,
Professor of Medicine and DGIM member since 1992,
was appointed Interim Director in June, 2009. The division continues to sponsor a wide variety of educational,
clinical and research activities. Due to space constraints,
this report will highlight but a few.
The DGIM faculty includes ­­25 Full Time Faculty and
138 Clinical Faculty. Our faculty maintain thriving
clinical practices and serve as administrators, dedicated
educators, and successful researchers at 5 of Brown
University’s Alpert Medical School’s affiliated hospitals
– Rhode Island Hospital, Memorial Hospital of Rhode
Island, The Miriam Hospital, the Providence Veterans
Affairs Medical Center and Women & Infants’ Hospital.
Medical education, a chief focus of the Division’s mission, is conducted at the Brown affiliated hospitals and
involves the training of more than 200 residents as well
as medical students from the Alpert Medical School of
Brown University. DGIM faculty continues important leadership roles for the residency programs. Dr.
Dominic Tammaro was promoted to Program Director
for the Categorical Internal Medicine Residency and
continues as Program Director for the Preliminary
Internship. Dr. Kelly McGarry continues as Program
Director for the Brown General Internal Medicine Residency and Dr. Jennifer Jeremiah continues as Associate
Program Director for the Internal Medicine residencies sponsored by Rhode Island Hospital. Dr. Joseph
Rabatin is Associate Program Director for the Internal
Medicine Residency at Memorial Hospital of Rhode
Island. During this period 98 residents completed 3 or 4
years of training and have gone on to fellowships, chief
residencies, clinical practices, and clinician-educator
positions in a variety of settings, including communitybased practice, hospitalist practice and public health.
Twenty-one interns completed the 1-year program and
entered into specialty programs.
32
Mark Fagan, M.D. is Professor of Medicine
Interim Director, Division of General Internal Medicine
Internal Medicine-Pediatrics experienced significant
growth and change in the 2008 and 2009 academic
years. Suzanne McLaughlin, M.D., FACP, FAAP, joined
the faculty as the first dually-trained IM/Peds Combined Residency Program Director and Section Chief.
Sybil Cineas, M.D., FACP, FAAP, was promoted to Associate Program Director and Jennifer Gartman, M.D.
has joined the faculty and established a clinical practice
at the Medicine/Pediatrics Primary Care Center. In this
expansion, the Section of Medicine/Pediatrics has been
established within the Department of Pediatrics, but
maintains strong ties across the residency programs and
faculty teaching responsibilities within the Department of Medicine. Medical education, patient care
and advocacy, and clinical and educational research are
priorities within the section; some recent achievements
are highlighted below:
Dr. Cineas was recognized with a Warren Alpert Medical School of Brown University 2008 Excellence in
Teaching Award. Dr. Toll is a 2009 recipient of a Department of Medicine Beckwith Family Teaching Award.
All faculty precept residents and medical students at
the Medicine Pediatrics Primary Care Clinic at Rhode
Island Hospital. Drs. Kristin Anderson and Kimberly
Babb contribute additional clinical and precepting
sessions. The MPPCC is piloting a refugee clinic to
a c a d e m i c y e a r s 20 08 a n d 20 09
provide intake services and on-going care for newly
resettled refugee adults and families. Clinical care
responsibilities extend beyond the clinic to additional
sites: Dr. Gartman has added clinical responsibilities at
the Rhode Island Training School, providing primary
care for incarcerated youths, and Dr. Cineas served as
a peer-elected member of the Rhode Island Free Clinic
Medical Advisory Committee, 2007–2008.
Dr. McLaughlin is a 2009 recipient of a grant from the
Picker Institute/Gold Foundation to develop resident
curriculum for health care transition. Dr. Toll continues as the Senior Team Leader for the MPPCC site’s
on-going participation in the statewide quality improvement initiative: Rhode Island Chronic Care Collaborative for Diabetes.
Taking advantage of the Division’s strength in Women’s
Health, Drs. Kelly McGarry, Christine Duffy and
Iris Tong have developed a Women’s Health Track for
residents. The goals of the women’s health track are to
enable residents to: 1) understand how medical illness
affects women differently than men from a medical and
psychosocial perspective; 2) acquire competency and
expertise in women’s health beyond that of a general
internist; 3) participate in scholarly work (research project, curriculum development) related to women’s health;
and 4) develop a mentoring relationship with a women’s
health expert. There are currently four residents in the
Women’s Health Track.
DGIM faculty serve as the attending physicians for the
inpatient general medicine service and medicine consultation service. In addition, they serve as preceptors
for the residents’ ambulatory clinics. In these settings,
they provide clinical care, bedside teaching, lectures,
feedback, and evaluation for residents and medical
students. Furthermore, nearly 60 General Internal
Medicine Community Physician Faculty and 30 Subspecialty Faculty served during these years as preceptors in our Community-Based Teaching Program,
providing a second continuity ambulatory experience
for 2nd and 3rd year residents.
DGIM faculty play a major role in teaching Brown
medical students across the four years of medical school.
During this period Dr. Iris Tong was appointed Course
Director for first year Doctoring Course. A number
of DGIM faculty serve as small group leaders and
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
clinical mentors for students in the first and second
year Doctoring Courses. For third year students, Mark
J. Fagan, M.D. continues as Clerkship Director for the
Core Clerkship in Medicine, and Joseph Rabatin, M.D.
is Site Director for the clerkship at Memorial Hospital
of RI. DGIM faculty play a critical role in the core
clerkship, serving as inpatient attendings, outpatient
preceptors, small group leaders, curriculum developers,
evaluators and career advisors. For fourth year students,
Kelly McGarry M.D. serves as Subinternship Director
at Rhode Island Hospital, and Mary Hohenhaus is Subinternship Director at Miriam Hospital. Many students
work with DGIM faculty on research projects, clinical
electives, longitudinal clerkships or in community-based
practices. Several of our faculty serve as Dean’s Letter
writers and career advisors for fourth year students.
The Division continues its exchange program with Cabral Y Baez Hospital in Santiago, Dominican Republic.
This elective, under the direction of Drs. Mark Fagan
and Joseph Diaz, is available to internal medicine residents as well as Brown medical students. Over the past
5 years, more than 50 medical students, residents, and
Division faculty have participated in the exchange. The
program also has also hosted one month rotations for
24 Dominican internal medicine residents at Brown.
Cabral y Baez is a large, public teaching hospital in
Santiago, the second largest city in the Dominican Republic. The hospital has a four-year internal medicine
residency program, and the goal of the exchange is to
integrate into clinical activities as much as possible. In
the elective, residents and students work with inpatient
teams of Cabral residents and faculty, attend teaching
conferences, and participate in the hospital’s outpatient
clinics. In addition, our trainees have the opportunity
to work in a clinic in a rural area about 30 minutes
from the hospital.
Dr. Michael Stein has worked with physicians at Cabral
y Baez to enhance the delivery of HIV services. This
collaboration has been successful in bringing up-to-date
HIV treatment to Santiago, advocating for increased
resources for HIV care, and establishing a database of
more than 1000 HIV patients followed at Cabral.
At the Governor Street Primary Care Center, Drs.
Francis Basile, Michael Johnson, Tom Bledsoe, Jeanne
Oliva and Tony Wu have embarked on a project to
create a patient-centered medical home. The Chronic
33
gener al internal medicine
Care Sustainability Initiative, now in its second year,
establishes enhanced standards for patient access and
communication, charting tools for organizing clinical
information, support for patient self-management, and
systematic tools for tracking lab tests and referrals. The
initiative focuses on the care of patients with three
chronic conditions: type 2 diabetes, coronary artery
disease and depression. At the conclusion of the initiative, which is funded by all of Rhode Island’s commercial insurers, researchers will measure changes in
practice patterns, clinical outcomes, and both patient
and physician satisfaction.
Three new faculty members have joined the DGIM during the past 2 academic years:
Rebekah Gardner, M.D. obtained her undergraduate
degree from the University of Virginia, attended medical school at New York University School of Medicine,
and completed her internal medicine residency and
General Internal Medicine fellowship at the University
of California, San Francisco. Dr. Gardner divides her
time between DGIM and Quality Partners of Rhode
Island, where she is a Senior Medical Scientist with the
Safe Transitions Project.. In the DGIM, she attends on
the inpatient teaching service and precepts in the Medical Primary Care Unit.
Susan Oliverio, M.D., M.P.H. is a graduate of Framingham State College where she obtained a B.S. in Food
and Nutrition. She attended medical school at Boston
University School of Medicine, completed her residency
training in general internal medicine at Brown, and
obtained a Masters of Public Health from Boston University. In addition to precepting in the Medical Primary
Care Unit, Dr. Oliverio works at the South End Community Health Center in Boston. Her interests include
women’s health, nutrition, and patient education with
a focus on developing materials for populations with
low literacy. She also has expertise in using multimedia
approaches to medical education.
Sarita Warrier, M.D. completed her undergraduate
degree and medical school at the University of Michigan, followed by a general internal medicine residency
at Brown. She attends on the inpatient teaching service,
precepts in the Medical Primary Care Unit, and coordinates the Objective Structured Clinical Examination for
third year medical students. She is Chair of the Young
Physicians Council of the Rhode Island Chapter of the
34
American College of Physicians. Her academic interests
include medical education, the humanities and medicine, and health care for refugees.
The DGIM Research Section, directed by Peter
Friedmann, M.D., M.P.H. received a number of NIH
grants to fund exciting new research projects and
career development. Dr. Friedmann secured funding
from NIDA for two R01 awards: “Stabilize Addiction/
Affect, Begin Inmates’ Interferon for HCV of Liver”
and “Treatment Study Using Depot Naltrexone.” He
also received a 5-year renewal of the NIDA U01for the
Criminal Justice Drug Abuse Treatment Studies (CJDATS2) Rhode Island Research Center. Susan Ramsey,
Ph.D. was awarded a new R01 from NIAAA for a
project entitled “Brief Alcohol Intervention to Reduce
At-Risk Drinking Among Type 2 Diabetes.” Christine
Duffy, M.D. received a K07 career development award
entitled “Measuring Preferences for Fertility in Breast
Cancer for a Decision Aid” from the NCI. Susan Kiene,
Ph.D. also initiated a career development (K01) award
from the NIMH entitled “Client-Centered Counseling
During Routine/Opt-Out Testing in Uganda.”
Magdalena Harrington, a doctoral candidate in the Psychology Behavioral Science Program at the University
of Rhode Island, joined the group in December 2008 to
support the group’s needs for statistical programming.
Traci Craig Green, a Ph.D.-level epidemiologist has
been recruited from the Yale School of Public Health to
provide further methodological expertise and develop
her research interests in HIV/AIDS, pain medicine,
health services research, correctional health and substance abuse. Continued growth of the research section
is planned for the coming year.
At Memorial Hospital of Rhode Island, Division of
General Internal Medicine researcher Dr. Jennifer
Clarke continues her work with incarcerated populations and recently received a grant from NIH/NIDA
to support her project “Sustaining Tobacco Abstinence
after Incarceration.” Dr. Joseph Diaz continues his work
on decision aids for colorectal cancer screening, and
Dr. Michele Cyr serves as the PI for the MHRI site for
the National Cancer Institute of Canada breast cancer
prevention trial of examastane vs. placebo.
Michael Stein, M.D., Professor of Medicine & Community Health, has established a General Medicine
research outpost at Butler Hospital. He continues to
a c a d e m i c y e a r s 20 08 a n d 20 09
do behavioral intervention studies, focused on substance using populations and persons at risk for HIV.
His current projects include: An Alcohol Intervention
for Incarcerated Women, Insomnia and Drug Relapse Risk, Antidepressant Use During Office-Based
Buprenorphine, Varenicline vs. Nicotine Replacement
for Methadone-Maintained Smokers, Efficacy of CBT
for Adherence and Depression in HIV Care Settings,
Linkage of Hospitalized Opioid Users to Buprenorphine, Reduction of Medical Complications Associated
With Injection Drug Use, A Brief Marijuana Intervention for Adolescent Women.
Dr. Stein maintains a primary care practice at 111
Plain Street. He is also involved in the Dominican
Republic exchange program, assisting with HIV clinical care in Santiago.
The Division of General Internal Medicine, the largest
division in the Department of Medicine, is pleased and
proud to report on two years of continued progress in
pursuit of our goals for excellence in education, clinical
care and research.
f a c u lt y m e mb e r s
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Mark J. Fagan, M.D. Interim Director
Michele Cyr, M.D.
Peter Friedman, M.D. MPH
Karen Rosene-Montella, M.D.
Michael Stein, M.D.
Associate Professors
Robert Crausman, M.D.
Joseph Diaz, M.D.
Lucia Larson, M.D.
Kelly McGarry, M.D.
Anne W. Moulton, M.D.
Thomas O’Toole, M.D.
Raymond Powrie, M.D.
Dominick Tammaro, M.D.
Assistant Professors
Ghada Bourjeily, M.D.
Jennifer Clarke, M.D.
Christine Duffy, M.D., MPH,
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Rebekah Gardner, M.D.
Susan Kiene, Ph.D.
Suzanne McLaughlin, M.D., M.S.*
Margaret Miller, M.D.
Paul A. Pirraglia, M.D.
Mary Reich Cooper, M.D.
Mark Schleinitz, M.D.
Investigators
Patricia Engler, Ph.D..
Clinical Faculty
(Hospital and Foundation Based)
Professors
Carol Landau, Ph.D.
Associate Professors
Khaja Ahmend, M.D.
Thomas Bledsoe, M.D.
Amos Charles, M.D.
Yul Ejnes, M.D.
Jennifer Jeremiah, M.D.
Michael Macko, M.D.
Russell Settipane, M.D.
Assistant Professors
Ali Akhtar, M.D.
Jeffrey Austerlitz, M.D.
Francis X. Basile, M.D.
Dawna Blake, M.D.
Paul Breiding, M.D.
Stefano Cazzaniga, M.D.
Pradeep Chopra, M.D.
Sybil Cineas, M.D.*
Bradley Collins, M.D.
Shiavax Cowasji, M.D.
Wilfred A. Curioso, M.D.
Ghassan Elkadi, M.D.
Michael Felder, D.O..
Jennifer Gartman, M.D.*
Amy S. Gottlieb, M.D.
Nicholas Grumbach, M.D.,
Meghan Hayes, M.D.
David Herec, M.D.
Debra S. Herman, M.D.
Michael Johnson, M.D.
Warren Licht, M.D.
Michael Maher, M.D.
Steven Mallozzi, M.D.
Donnah Mathews, M.D.
Niharika Mehta, M.D.
Laura Ofstead, M.D.
35
gener al internal medicine
Jeanne Oliva, M.D.
Susan Oliverio, M.D.
Joseph Rabatin, M.D.
Mark Ryan, M.D.
Benjamin Sapers, M.D.
Kurush Setna, M.D.
Michael S. Siclari, M.D.
Michelle A. Stozek Anvar, M.D.
Edward Stulik, M.D.
James Sullivan, M.D.
Iris Tong, M.D.
Elizabeth Toll, M.D.,
Sarita Warrier, M.D.
Barbara Weil, M.D.
Karen L. Woolfall-Quinn, M.D.
Tony Wu, M.D.
Najam Zaidi, M.D.
Instructors
Kristin Anderson, M.D.
Joyce Chang, M.D.
Mary Hohenhaus, M.D.
Thomas Jean, M.D.
Jennifer L. Maude, M.D.
Louis Moran, M.D.
Lorna Russell, M.D.
Parviz Shavady, M.D.
Volunteer Clinical Faculty
Associate Professors
Reid Coleman, M.D.
Frederick Crisafulli, M.D.
Tariq Malik, M.D.
Edward Martin, M.D.
Assistant Professors
Ahmad Al-Raqqad, M.D.
Kim Amin, M.D.
Rex Appenfeller, M.D.
Steven Brin, M.D.
Frank Capizzo, M.D.
Joyce Coppola, M.D.
Anne Cushing-Brescia, M.D.
Allen Dennison, M.D.
Peter M. Eller, M.D.
David Fried, M.D.
Nicholas Grumbach, M.D.
Geoffrey Hamilton, M.D.
Pamela Harrop, M.D.
Christine Herbert, M.D.
Guang Hu, M.D.
36
Sadia Iftikhar, M.D.
Mark Jacobs, M.D.
Steven Kempner, M.D.
Razib Khaund, M.D.
Nancy T. Littell, M.D.
Rosario Manalo, M.D.
Fadi Mansourati, M.D.
David A. Marcoux, M.D.
Steven G. McCloy, M.D.
John Miskovsky, M.D.
Vincent Pera, M.D.
Jose Polanco, M.D.
Roy Poses, M.D.
Richard J. Ruggieri, M.D.
Larry Schoenfeld, M.D.
Howard Schulman, M.D.
Ronald Schwartz, M.D.
Stephen Scott, M.D.
John Stoukides, M.D.
Caroline Troise, M.D.
Edward Wheeler, M.D.
Instructors
Daniel Asiedu, M.D., Ph.D.
Kimberly S. Babb, M.D.
Geoffrey Berg, M.D.
Douglas Blecker, M.D.
Praveen Bondalapati, M.D.
Hector Derreza, M.D.
Jeffrey Drogin, M.D.
Elaine B. Fain, M.D.
Bruce E. Fischer, M.D.
Levis Guzman, M.D.
S. Iftikihar Hussain, M.D.
Vito Longobardi, M.D.
Vincent Marcaccio, M.D.
Michael O’Connell Jr., M.D.
Anthony R. Ricci, M.D.
Marina Rodriguez, M.D.
Jean Smith, M.D.
W. Tyler Smith Jr. M.D.
Arumugam Thanumalaya, M.D.
Sreekala Vasudevan, M.D.
Todd Viccione, M.D.
Jiaying Wen, M.D.
Teaching Associates
Katherine Carey Baker, M.D.
*Faculty is part of the Medicine Pediatrics Combined
Residency Program
AC A DEMIC Y E A RS 20 08 A ND 20 09
SELECTED HONORS
A N D S C H O L A R LY W O R K
Joseph A. Diaz, M.D.
Clinician Educator Award, Society of General Internal
Medicine New England Region, March 2008
Patricia A. Engler, Ph.D.
Invited Pr esentations
◆◆
Ramsey, S.E., Bell, K.M., & Engler, P.A. HIV
Risk Behavior Among Pregnant Drug Abusers. Department of Psychology, Royal Holloway,
University of London, U.K., April 9, 2008
Invited Pr esentations
◆◆
◆◆
Student Interest in Internal Medicine. Medical
Grand Rounds, University of California,
Davis School of Medicine, May 2008
◆◆
Developing a Career as a Medical Educator (Panel).
Clerkship Directors in Internal Medicine National
Meeting, Orlando, Florida, October 2008
Peter Friedmann, M.D., MPH
Honors And Awards
◆◆
◆◆
Member, American Society of Addiction
Medicine’s Expert Review Panel “Quality Care
Best Practice Models for the Treatment of Opioid
Addiction Using Buprenorphine.” 2008–09.
President, Association for Medical Education and
Research in Substance Abuse (AMERSA). 2007–09. Invited Pr esentations
◆◆
Linkage Between Primary Care, Mental Health and
Addiction Treatment.” 5th UK/European Symposium
on Addictive Disorders. Millennium Gloucester
Hotel, Kensington, London, England. May 10, 2008. Schol arly Activities
◆◆
Director, Research Section, Division of
General Internal Medicine. 2009–
◆◆
Director, Research Enhncement Award Program
(REAP) in Health Services Research and Development
(HSR&D), Providence VA Medical Center. 2008–12 ◆◆
Women’s Health Advisor on Menopause,
National Women’s Health Report
◆◆
Health Content Advisor – National
Women’s Health Resource Center
Kelly McGarry, M.D., FACP
Honors And Awards
◆◆
Listed in Best Doctors in America – a database
representing the top 5% of doctors in over
400 subspecialties of medicine, 2007.
◆◆
Listed in Best Doctors in America – a database
representing the top 5% of doctors in over
400 subspecialties of medicine, 2008.
Invited Pr esentations
◆◆
◆◆
Education Director for the National
Center of Excellence in Women’s Health,
Brown University and Women & Infants
Hospital, Providence, RI, 2005–2008.
◆◆
Member, Advisory Board for 5 Minute Clinical Consult,
Philadelphia, PA, Lippincott Williams & Wilkins
◆◆
Reviewer for American College of Physicians,
National Abstract Review Board
◆◆
Reviewer for American Family Physician
Suzanne McLaughlin, M.D., FACP, FAAP
Honors And Awards
◆◆
Member, UCLA/RIT Resident Obesity Training
National Advisory Board, 2008–present
◆◆
Member, Transition Committee, National
Medicine/Pediatrics Program Directors’
Association, 2007–present
Schol arly Activities
◆◆
Honors And Awards
Society of General Internal Medicine - Appointed
position (National): Member, Women’s
Health Task Force. 2008–present
Co-Facilitator, “Getting Through the
Match.” American College of Physicians
Annual Sessions for 2007, 2008, 2009.
Schol arly Activities
Amy S. Gottlieb, M.D.
◆◆
Landau, C. “Menopause and Mood: Controversies and
Questions.” United Nurses and Allied Professionals
Annual Meeting, Providence, RI, June 10, 2008.
Schol arly Activities
Mark J. Fagan, M.D.
Invited Pr esentations
JULY 1, 20 07– JUNE 30, 20 09
Carol Landau, Ph.D.
Honors And Awards
◆◆
◆
PI, Picker Institute/Gold Foundation Challenge
Grant. Health Care Transition: A Resident
Learning Curriculum, 2009–2010
Paul A. Pirraglia, M.D.
Honors And Awards
◆◆
President, New England Region, Society
of General Internal Medicine
37
gener al internal medicine
◆◆
Chair, VISN1 Integrated Primary Care
Mental Health Program Evaluation Team Schol arly Activities
◆◆
PI: VISN1 Innovation Grant, 2009–2010
◆◆
Site PI: VA Health Services Research & Development,
Partners in Dementia Care, 2006–2010
Roy Poses, M.D.
◆◆
Invited Pr esentations
◆◆
Chair, Professionalism Sub-Committee,
Clinical Practice Committee, Society for
General Internal Medicine, 2007–present.
Invited Pr esentations
◆◆
◆◆
Seminar leader, seminar on understanding and
addressing external threats to ethical and evidencebased practice, 12th National Undergraduate
Bioethics Conference, Cambridge, MA, 2009.
“Health Care Ethics, and the Role of Vested Interests
and Conflicts of Interest in Health Research,” Special
Seminar, Health Intervention and Technology
Assessment Program (HITAP), Ministry of
Public Health, Nonthaburi, Thailand, 2009
◆◆
Invited Participant, Prince Mahidol Award
Conference, Bangkok, Thailand, 2009
◆◆
Coordinator and faculty, special session on health care
governance, leadership and ethics, Annual Research
Meeting, AcademyHealth, Chicago, IL, 2009.
◆◆
Visiting Professor, Division of General Internal
Medicine, Department of Internal Medicine,
University of Iowa, Iowa City, IA, 2009
Schol arly Activities
◆◆
Grant Reviewer, National Medical Research
Council, Ministry of Health, Singapore, 2007
◆◆
Scientific Committee, Acta Medica Colombiana, 2008–
◆◆
External Reviewer, Sheikh HaM.D.an Bin
Rashid Al Maktoun Award for the Best Medical
College/Institute in the Arab World, 2008
◆◆
Member, Small Business: Health of the
Population Special Emphasis Panel, National
Institutes of Health, Bethesda, M.D., 2007–
◆◆
Member, Challenge Grants Panel 1,
National Institutes of Health
Dominic Tammaro, M.D.
Invited Pr esentations
◆◆
Mastering the Match, ACP American College
of Physicians, Annual Sessions, Washington,
DC, Co-Presenter, May 2008
◆◆
Morning Report: Fourteen Simultaneous Sessions.
Association of Program Directors in Internal Medicine,
Annual Sessions, Washington, DC, Overall Workshop
Director/Small Group Facilitator, May 2008
◆◆
Mastering the Match, ACP American
College of Physicians, Annual Sessions,
Philadelphia, PA, Co-Presenter, April 2009
◆◆
Morning Report: Fourteen Simultaneous Sessions,
Association of Program Directors in Internal Medicine,
Annual Sessions, Dallas, TX, Overall Workshop
Director/Small Group Facilitator, April 2009
Elizabeth Toll, M.D.
Honors And Awards
◆◆
Department of Medicine Beckwith
Family Teaching Award, 2009
Invited Pr esentations
◆◆
A Practical Approach to Mental Health Care
Treatment in the Pediatric Primary Care Setting.
Co-presenter at the Pediatric Academic Societies
National Meeting, Baltimore, M.D., May, 2009
Schol arly Activities
◆◆
Senior Team Leader, Medicine Pediatrics Primary
Care Center site for Rhode Island Chronic Care
Collaborative for Diabetes, 2003–present
Joseph Rabatin, M.D.
Sarita Warrier, M.D.
Invited Pr esentations
Honors And Awards
◆◆
Workshop Harvard SGIM regional meeting teaching
residents communication skills March 2009
Schol arly Activities
◆◆
Advisor to Reynolds grant for clerkships
Susan Ramsey, Ph.D.
Honors And Awards
◆◆
38
HIV Risk Behavior Among Pregnant Drug Abusers,
Department of Psychology, Royal Holloway,
University of London, U.K., April 9, 2008.
Schol arly Activities
Honors And Awards
◆◆
Associate Editor, Substance Abuse: Research
and Treatment. 2008–present
Member, Editorial Board, Substance Abuse:
Research and Treatment. 2007–2008
◆◆
Best Clinical Vignette Poster Presentation Brown Internal Medicine Residency Program,
Senior Resident Research Day, May 2008
◆◆
Harvey P. Lesselbaum Award - Brown Internal
Medicine Residency Program/ June 2008
a c a d e m i c y e a r s 20 08 a n d 20 09
S ELEC T ED P U B LICAT ION S
◆◆
Diaz JA, Roberts MB, Goldman RE, Weitzen
S, Eaton CB. Effect of Language on Colorectal
Cancer Screening Among Latinos and NonLatinos. Cancer Epidemiology, Biomarkers
& Prevention. 2008;17(8):2169–2173.
Fagan MJ, Chen JT, Diaz JA, Reinert SE,
Stein M.D.. Do Internal Medicine Residents
Find Pain Medication Agreements Useful?.
Clinical Journal of Pain. 2008:24(1)35–38. ◆◆
Kiene, S. M., Barta, W. D., Tennen, H., &
Armeli, S. (2009). Alcohol, helping young adults
have sex with casual partners: Findings from
a daily diary study of alcohol use and sexual
behavior. Journal of Adolescent Health, 44, 73–80.
◆◆
Kiene, S. M., Tennen, H., & Armeli, S. (2008). Today
I’ll use a condom, but who knows about tomorrow:
A daily process study of variability in predictors of
condom use behavior. Health Psychology, 27, 463–472.
◆◆
Kiene, S. M., Simbayi, L. C., Abrams, A., Cloete,
A., Tennen, H., & Fisher, J. D. (2008). High
rates of unprotected sex occurring among HIVpositive individuals in a daily diary study in South
Africa: The role of alcohol use. Journal of Acquired
Immune Deficiency Syndromes, 49, 219–226.
Mark J. Fagan, M.D.
◆◆
Fagan JM, Chen JT, Diaz JA, Reinert SE, Stein M.D..
Do Internal Medicine Residents Find Pain Medication
Agreements Useful? Clin J Pain. 2008;1:35–8.
◆◆
Hauer KE, Fagan MJ, Kernan W, Mintz M,
Durning SJ. Internal Medicine Clerkship Directors’
Perceptions about Student Interest in Internal
Medicine Careers. J Gen Intern Med. 2008;7:1101–4.
◆◆
Hauer KE, Durning SJ, Kernan W, Fagan MJ,
Mintz M, O’Sullivan PS, Battistone M, DeFer
T, Elnicki M, Harrell H, Reddy S, Boscardin
CK, Schwartz M.D.. Factors Associated with
Medical Students’ Career Choices Regarding
Internal Medicine. JAMA 2008;300:1154–64.
Carol Landau, Ph.D.
◆◆
McGarry KA, Clarke JG, Landau C, Cyr MG.
Caring for vulnerable populations: Curricula
in U.S. internal medicine residencies. Journal
of Homosexuality 2008;54(3):225–232.
◆◆
McGarry KA, Landau, C. Menopause and Mood.
Medicine & Health RI 2008;91(3):81–85.
◆◆
Landau C: Rebuilding America’s psychological
infrastructure: Helping our children change.
The Brown University Child and Adolescent
Behavior Letter (CABL) February, 2009:8.
Peter Friedmann, M.D.
◆◆
◆◆
◆◆
Friedmann PD, Jiang L, Richter KP. Cigarette
smoking cessation services in outpatient substance
abuse treatment programs in the United States.
J Subst Abuse Treat. 2008;34: 165–172.
Friedmann PD, Katz EC, Rhodes AG, Taxman
FS, O’Connell DJ, Frisman LK, Burdon WM,
Fletcher BW, Litt M.D., Martin SS. Collaborative
behavioral management for drug-involved
parolees: Rationale and design of the Step’n Out
Study. J Offender Rehabil. 2008; 47(3): 290–318.
Friedmann PD, Rose JS, Swift R, Stout R,
Millman RP, Stein M.D.. Trazodone for sleep
disturbance after alcohol detoxification. Alc
Clin Exp Res. 2008; 32(9): 1652–1660.
Amy S. Gottlieb, M.D.
◆◆
Gottlieb AS. Intimate partner violence: a
clinical review of screening and intervention.
Women’s Health. 2008;4:529–539.
◆◆
Gottlieb AS. Intimate partner violence. (Feature
article) Journal Watch Women’s Health. 2008;13:77–78.
◆◆
Gottlieb AS. Intimate partner violence: a
guide for clinicians. Sexuality, Reproduction
& Menopause. 2008;6:10–14.
j u ly 1 , 20 07 – j u n e 30 , 20 09
Susan Kiene, M.D.
Joseph A. Diaz, M.D.
◆◆
◆
Kelly A. McGarry, M.D.
◆◆
Hohenhaus MH, McGarry KA, Col NF.
Hormone therapy for the prevention of bone
loss in menopausal women with osteopenia: Is
it a Viable Option? Wolters Kluer/Adis Data
Information BV. Drugs; 2007;67(16):2311–2321.
◆◆
McGarry KA, Clarke JG, Landau C, Cyr MG.
Caring for vulnerable populations: Curricula
in U.S. internal medicine residencies. Journal
of Homosexuality 2008;54(3):225–232.
◆◆
Politi MC, Clark MA, Rogers ML, McGarry K,
Sciamanna, CN. Patient-Provider communication
and cancer screening among unmarried women.
Patient Education and Counseling. 2008;73:251–255.
Paul A. Pirraglia, M.D.
◆◆
Pirraglia PA, Taveira TH, Cohen LB, Wu W.
The moderating effect of depression diagnosis
on the effectiveness of a multi-factorial
cardiovascular risk reduction clinic. Preventing
Chronic Disease. 2008 Oct;5(4):A127. 39
gener al internal medicine
◆◆
◆◆
Pirraglia PA, Taveira TH, Cohen LB, Dooley
A, Wu WC. Maintenance of cardiovascular
risk goals in veterans with diabetes after
discharge from a cardiovascular risk reduction
clinic. Preventive Cardiology 12:3–8, 2009. Pirraglia PA, Biswas K, Kilbourne AM, Fenn H, Bauer
MS. A Prospective Study of the Impact of Comorbid
Medical Disease on Bipolar Disorder Outcomes.
Journal of Affective Disorders 115(3):355-9, 2009.
Roy Poses, M.D.
Joseph Rabatin, M.D.
◆◆
An P, Rabatin JS, Manwell LB, Linzer M,
Brown RL, Schwartz M. “Effects of Caring
for Difficult Patients: Data from the MEMO
Study. Archives of Internal Medicine. Jan 2009
◆◆
Baier Manwell L, Williams ES, Babbott S,
Rabatin JS, Linzer M. “Physician perspectives
and quality and error in the outpatient setting”.
Wisconsin Medical Journal. July 2009
Susan Ramsey, Ph.D.
◆◆
Brehaut J, Poses R, Shojania K, Lott A, Man-SonHing M, Grimshaw J, Bassin E. Do physician
judgment biases predict inappropriate use of
treatments? Implementation Science 2007: 2: 18–29
◆◆
Ramsey, S.E., Engler, P.A., & Stein, M.D.
(2007). Addressing HIV risk behavior among
pregnant drug abusers: An overview. Professional
Psychology: Research and Practice, 38(5), 518–522.
◆◆
Wu WC, Schifftner TL, Henderson WG, Eaton
CB, Poses RM, Uttley G, Sharma SC, Vezeridis M,
Khuri SF, Friedmann PD. Levels of preoperative
hematocrit predict postoperative cardiovascular and
fatal outcomes in elderly patients undergoing major
non-cardiac surgery. JAMA 2007; 297: 2481–2488.
◆◆
Ramsey, S.E., & Engler. P.A. (2009). At-risk
drinking among diabetic patients. Substance
Abuse: Research and Treatment, 3, 15–23.
◆◆
Ramsey, S.E., Bell, K.M., & Engler, P.A. (in
press). HIV risk behavior among female substance
abusers, Journal of Addictive Diseases.
RESEARCH
BASIC RESEARCH
DirectIndirectTotal
Academic Year 2008
Academic Year 2009
S ELEC T ED
CLINICAL RE S EARCH
Dawna Blake, M.D.
◆◆
VISN Collaborative for Improving Hypertension
Management with ATHENA-HTN, Veterans Affairs
Jennifer Clarke, M.D.
◆◆
MI: Empowering Women to Make Contraceptive
Choices While Incarcerated, National Institute
of Child Health and Human Development
◆◆
Sustaining Tobacco Abstinence After Incarceration,
National Institute on Drug Abuse
◆◆
Continuum of Care for Drug-Involved
Offenders, Rhode Island Hospital/NIDA
◆◆
Prevalence of Obesity and Weight Change
Among Incarcerated Women in Rhode
Island, The Rhode Island Foundation
Joseph A. Diaz, M.D.
◆◆
40
Colorectal Cancer Decisions Aids in Primary
Care, National Cancer Institute
$3,414,967
$4,768,653
◆◆
$1,080,077
$1,377,327
$4,495,044
$6,145,980
Colorectal Cancer Decisions Aids in Primary Care
(ARRA Supplement), National Cancer Institute
Christine Duffy, M.D., MPH
◆◆
Measuring Preferences for Fertility in Breast Cancer
for a Decision Aid, National Cancer Institute
◆◆
Measuring Preferences for Fertility in
Breast Cancer for a Decision Aid (ARRA
Supplement), National Cancer Institute
Peter Friedmann, M.D., MPH
◆◆
Stabilize Addiction/Affect, Begin Inmates’ Interferon
for HCV of Liver, National Institute on Drug Abuse
◆◆
Treatment Study Using Depot Naltrexone
(2/6) Rhode Island Protocol Treatment
Site, National Institute on Drug Abuse
◆◆
Continuum of Care for Drug-Involved
Offenders, National Institute on Drug Abuse
◆◆
Sustaining Tobacco Abstinence after
Incarceration, Memorial Hospital of RI/NIH
◆◆
Integrating Buprenorphine Opioid Treatment with
HIV Primary Care, The Miriam Hospital/HRSA
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
Opiate Replacement Therapy at Release from
Incarceration, The Miriam Hospital/NIDA
◆◆
Program to Integrate Psychosocial and Health Services
in Chronic Disease and Disability, Veterans Affairs
◆◆
Center on Systems, Outcomes & Quality in Chronic
Disease & Rehabilitation (SOQCR), Veterans Affairs
◆◆
National Criminal Justice Survey (Analysis of an
Existing Criminal Justice Drug and Treatment Services
– CJDATS Data Set), National Institute on Drug Abuse
◆◆
Drug Abuse Treatment Survey, National
Institute on Drug Abuse
Susan Kiene, Ph.D.
◆◆
◆◆
◆◆
Client-Centered Counseling During
Routine/Opt-Out HIV-Testing in Uganda,
National Institute of Mental Health
Dynamics of Risky and Safer Sexual
Behavior Among Couples in Rural
Uganda, The Rhode Island Foundation
Involving Male Partners in Antenatal Services to
Increase HIV-Testing and Family Planning Usage in
Rural Uganda, Women & Infants Hospital of RI
Paul A. Pirraglia, M.D.
◆◆
Depression and Anxiety, The Rhode Island Foundation
◆◆
Partners in Dementia Care, Veterans Affairs
Susan Ramsey, Ph.D.
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Cynthia Rosengard, Ph.D., MPH
◆◆
Partner-Specific HIV Risk Reduction
for Drug Using Incarcerated Adolescents,
National Institute on Drug Abuse
◆◆
Partner Specific Factors in Adolescent Sexual
Behavior, National Institute of Mental Health
Mark Schleinitz, M.D., M.S.
◆◆
Impact of State Medicaid Policy Changes on Nursing
Home Hospitalization, Brown University/RWJPRI
◆◆
State Policies and Health Systems Factors Associated
with Multiple Transitions, Brown University/NIH
◆◆
Screening Breast Ultrasound in High-Risk
Women, American College of Radiology/NCI
◆◆
ACRIN 6666 Decision and Cost Effectiveness Project,
American College of Radiology/Avon Foundation
Michael Stein, M.D.
◆◆
Antidepressants During Office-Based Buprenorphine,
National Institute on Drug Abuse
◆◆
A Brief Marijuana Intervention for Adolescent
Women, National Institute on Drug Abuse
◆◆
A Brief Alcohol Intervention for Incarcerated Women,
National Institute on Alcohol Abuse and Alcoholism
◆◆
Insomnia and Drug Relapse Risk,
National Institute on Drug Abuse
◆◆
Mid-Career Investigator Award in Substance Abuse
Research, National Institute on Drug Abuse
◆◆
Varenicline Versus Nicotine Replacement
for Methadone-Maintained Smokers,
National Cancer Institute
◆◆
Brief Alcohol Intervention to Reduce At-Risk
Drinking Among Type 2 Diabetes, National
Institute on Alcohol Abuse and Alcoholism
◆◆
Naltrexone for At-Risk and Problem Drinking in
Smoking Cessation, Brown University/NIAAA
◆◆
◆◆
Preventing Depression in MMT Patients on
Interferon, National Institute on Drug Abuse
Efficacy of CBT for Adherence and Depression in
HIV Care Settings, Mass General Hospital/NIMH
◆◆
◆◆
Brief Intervention to Reduce Drinking
Among Batterers, Butler Hospital/NIAAA
Linkage of Hospital Opioid Users to Buprenorphine,
National Institute on Drug Abuse
◆◆
◆◆
Brief Alcohol Intervention with Depressed Patients,
National Institute on Alcohol Abuse and Alcoholism
Reduction of Medical Complications Associated
with Injection Drug Use (ARRA Supplement),
University of Northern Colorado/NIDA
◆◆
Reducing HIV Risk Among Pregnant Women in
Drug Treatment, National Institute on Drug Abuse
41
gener al internal medicine
INTERNAL MEDICINE RESIDENCY PROGRAM AT MEMORIAL HOSPITAL OF RHODE ISLAND
Current Residents 2008–2009
Chief Resident
Rami S. Eltibi, M.D., University of Jordan, Jordan
PGY 1
Pavan Kumar Annamaraju, M.D. - Kasturba Medical College, India
Anas Al-Sadi, M.D. - King Edward Medical College, Pakistan
Mosaab Bagegni, M.D. - University of Al Fateh, Libya
Zeeshan Chauhan, M.D. - Kind Edward Medical College, Pakistan
Haitham Dababneh, M.D. - University of Jordan
Sankalp Gokhale, M.D. - Seth G.S. Medical College, India
Navin Kaini, M.D. - B.P. Koirala Institute of Health Sciences, Nepal
Feras Karadsheh, M.D. - Jordan University of Science & Technology
Sajid Saraf, M.D. - Army Medical College, Pakistan
Aravind Sekhar, M.D. - Bangalore Medical College, India
PGY 2
Rami Abumasmah, M.D. – Al Arab Medical College, Libya
AbdulRahman AbdulBaki, M.D. - University of Damascus, Syria
Wesam Ahmed, M.D. - Menoufia University, Egypt
Ali Al-Alwan, M.D. - University of Jordan, Jordan
Joseph Bautista, M.D. - University of the East, Philippines
Indira Konanur, D.O. - University of North Texas Health Science Center-Texas College of Osteopathic Medicine, Texas
Syed Naqvi, M.D. - King Edward Medical College, Pakistan
Aravind Sanjeevaiah, M.D. - Bangalore Medical College, India
Syeda Sayeed, M.D. - Dow Medical College, Pakistan
Omar Zmeili, M.D. - University of Jordan, Jordan
PGY 3
Saba Asad, M.D. - Fatima Jinnah Medical College for Women, Pakistan
Jaspreet Dhillon, M.D. - Government Medical College Patiala, India
Ahmad Ismail, M.D. - Jordan University of Science & Technology, Jordan
Jagan Kothapally, M.D. - Gandhi Medical College, India
Ashish Misri, M.D. - St. John’s Medical College, India
Priya Mital, M.D. - Maulana Azad Medical College, India
Saed Nemr, M.D. - Al-Quds University Faculty of Medicine, Jerusalem
Anna Ocasiones, M.D. - University of Santo Tomas, Philippines
Tarek Rashid, M.D. - Al-Fateh University School of Medicine, Libya
Ayesha Sheikh, M.D. - Allama Iqbal Medical College, Pakistan
42
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
RHODE ISLAND HOSPITAL / THE MIRIAM HOSPITAL
Current Residents 2009–2010
CHIEF RESIDENTS
Bevin Kenney, M.D.
Priscilla Merriam, M.D.
Kate Mavrich, M.D. University of Massachusetts
Jefferson Medical College
University of Pittsburgh
John Reagan, M.D.
Christopher McGowan,M.D.
Jefferson Medical College
SUNY–Medical College
Jamie Marquart, M.D.
Jenny Melli, M.D.
Rachel Rackow, M.D.
Lauren Schlanger, M.D.
University of Missouri
UM.D.NJ – RW Johnson
Alpert Medical School
SUNY Syracuse
Emily LeVeen, M.D.
Katherine Moore, M.D.
Maria Robles, M.D.
Helen Walsh, M.D.
University of Pennsylvania
University of Kansas
Indiana University
University of South FL.
Katharine Price, M.D.
Shivani Reddy, M.D.
Trong Trinh, M.D.
University of Rochester
New York University
Drexel University
Anthony Pham, M.D.
Lee Rabinowitz, M.D.
Bharath Sathya, M.D.
Robert Scaffidi, M.D.
Sameer Shah, M.D.
Peter Shorter, M.D.
Helen Shum, M.D.
Linsley Sikorski, M.D.
Jesse Soodalter, M.D.
Nathan Spence, M.D.
Joanne Szczygiel, M.D.
Kiley Toder, M.D.
Bridget Tracy, M.D.
Irene Yang, M.D.
Franklin Yates, M.D.
Univ. of Texas Medical
Jefferson Medical College
UM.D.NJ Medical School
Tufts University
Tufts University
Univ. of South Carolina
Drexel University
New York University
Alpert Medical School
University of New Mexico
Albany Medical College
Albany Medical College
SUNY Downstate
Jefferson Medical College
Temple University
Mahim Kapoor, M.D.
Richard LaRue, M.D.
Syed Latif, M.D.
Evan Mariash, M.D.
Joanna Mecca, M.D.
Nikhil Mull, M.D.
Melissa Pabalan, M.D.
Lakshmi Ravindran, M.D.
UM.D.NJ–RW Johnson
University of Tennessee
Alpert Medical School
Chicago Medical School
UM.D.NJ-RW Johnson
Drexel University
University of Pittsburgh
University of Missouri
GENERAL INTERNAL MEDICINE/PRIMARY CARE
PGY-1
Matthew Brumbaugh, M.D.
Heather Cassidy, M.D.
Julia Jacobs, M.D.
Amanda Livingston, M.D.
Alpert Medical School
University of Colorado
University of Louisville
Chicago Medical School
PGY-2
Christina Beyer, M.D.
Aruna Chandrasekhar, M.D.
Katherine Fox, M.D.
Brian Hollenbeck, M.D.
University of Pittsburgh
University of Texas
UM.D.NJ – RW Johnson
University of Kansas
PGY-3
Lorena Bonilla, M.D.
Joanna D’Afflitti, M.D.
Laura Flynn, M.D.
Joseph Frank, M.D.
University of Colorado
SUNY Downstate
Virginia Comm. University
Indiana University
CATEGORICAL INTERNAL MEDICINE
PGY-1
Joanna Bradley, M.D.
Nicholas Csikesz, M.D.
Cheston Cunha, M.D.
Ignacio Echenique, M.D.
Katie Fillion, M.D.
Sophia Fircanis, M.D.
Jennifer Fung, M.D.
Geetika Gupta, M.D.
William Hahn, M.D.
Laura Heise, M.D.
Mark Hepokoski, M.D.
Darren Hirsch, M.D.
Robert Kuhn, M.D.
Aida Morse, M.D.
Dennis Oyieng’o, M.D.
Tina Park, M.D.
UM.D.NJ – RW Johnson
Univ. of Massachusetts
Penn. State University
Jefferson Medical College
University of Vermont
New York Med. College
SUNY Downstate
University of Rochester
SUNY Syracuse
University of New Mexico
University of Minnesota
Jefferson Medical College
SUNY Downstate
University of Pennsylvania
Moi University
UM.D.NJ/RW Johnson
PGY-2
Matthew Baker, M.D.
Brian Barr, M.D.
Kenneth Bishop, M.D.
Nida Chaudhary, M.D.
Philip Choi, M.D.
Jennifer Colvin, M.D.
Richard DeSouza, M.D.
Lauren Dudley, M.D.
University of Pittsburgh
Stony Brook Univ. Health
Univ. of Massachusetts
Drexel University
Mt. Sinai School of Med
Loyola University
Univ. of Massachusetts
University of Connecticut
43
gener al internal medicine
Rhode Island Hospital / The Miriam Hospital
Current Residents 2009–2010
CATEGORICAL INTERNAL MEDICINE continued
PGY-2
Samuel Evans, M.D.
Arkadiy Finn, M.D.
Kristen Hagar, M.D.
Christine Ho, M.D.
Alina Huang, M.D.
Matthew Hudson, M.D.
Jennifer Hwang, M.D.
Omar Hyder, M.D.
Fahmeedah Jamaluddin, M.D.
SUNY Downstate
Tufts University
University of Miami
A. Einstein College of Med
University of Pittsburgh
University of Pittsburgh
Chicago Medical School
Alpert Medical School
University of Missouri-KC
Katharine Robertson, M.D.
Larry Siu, M.D.
Rebecca Soinski, M.D.
Sharmila Subaran, M.D.
Jeremy Thaden, M.D.
Paul Trowbridge, M.D.
Chia-Ching Wang, M.D.
Lauren Welicky, M.D.
New York Med. College
SUNY Downstate
Jefferson Medical College
University of Connecticut
Mt Sinai School of Med
Wayne State University
SUNY Stony Brook
Stony Brook Univ. Health
John Mills, M.D.
Mary Ellen O’Brien, M.D.
Benjamin O’Donnell, M.D.
Kathryn O’Donnell, M.D.
Melissa Piech, M.D.
William Robinson, M.D.
Aaron Samuels, M.D.
Kinjal Shah, M.D.
Bashar Staitieh, M.D.
Elizabeth Stevenson, M.D.
Gniewomira Swaldek, M.D.
Nilofar Syed, M.D.
Hao Tran, M.D.
Jill Tremblay, M.D.
Marisa VanPoznak, M.D.*
UM.D.NJ - R. W. Johnson
UM.D.NJ - R. W. Johnson
Med. University of Ohio
Temple University
University of Connecticut
Albany Medical College
University of Maryland
Creighton University
University of Kansas
Drexel University
Poznan Univ. of Medicine
Case Western Reserve
Drexel University
Georgetown University
Dartmouth Medical School
University of South Florida
Texas Tech University
Alpert Medical School
NY Medical College
Alpert Medical School
Virginia Comm. University
Andrew Hawkins, M.D.
Serggio Lanata, M.D.
Jeffrey Liu, M.D.
Rajiv Magge, M.D.
Michael Seidler, M.D.
Univ. of North Carolina
Univ. of South Florida
Alpert Medical School
University of Pittsburgh
McGill University
University of Connecticut
Jefferson Medical College
Anne Gaboney, M.D.
Stephanie Tecum, M.D.
University of Indiana
Alpert Medical School
PGY-2
Sarah Bagley, M.D.
Georgetown University
Alexander Diaz de VillaVilla, M.D. Yale University
Pooja Rao, M.D.
Natthapol Songdej, M.D.
University of Rochester
University of Rochester
PGY-3
Justin Eldridge, M.D.
Sylvia LaCourse, M.D.
Jefferson Medical College
University of Louisville
Raina Phillips, M.D.
Natasha Rybak, M.D.
University of Illinois
Alpert Medical School
PGY-4
Jacqueline Firth, M.D.
Charlene Flash, M.D.
Tulane University
Robert Wood Johnson
Medical School
Susanna Winston, M.D.
University of Minnesota
PGY-3
Stephanie Ajudua, M.D.
Megan Baumgart, M.D.
Man Chin Chang, M.D.
Nathan Connell, M.D.
Samir Dalia, M.D.
Sarah DeNucci, M.D.
Kathleen Eldridge, M.D.
Meghana Gadgil, M.D.
Matthew Griffin, M.D.
Aarti Gupta, M.D.
Ajita Kundaikar, M.D.
Jianqing Li, M.D.
Zeina Wajdi Maani, M.D.
Joseph Manlolo, M.D.
Daniel Markley, M.D.
Bryna McConarty, M.D.
Alpert Medical School
Albany Medical College
University of Connecticut
University of Miami
Northeastern Ohio Univ.
Alpert Medical School
Jefferson Medical College
UM.D.NJ- R. W. Johnson
St.Christopher Col. of Med
SUNY Buffalo
SUNY Downstate
Drexel University
Jordan University
Med. College of Wisconsin
UM.D.NJ- R. W. Johnson
Univ. of Massachusetts
PRELIMINARY INTERNAL MEDICINE
PGY-1
Brett Blake, M.D.
Erik Cantrell, M.D.
Sandy Chira, M.D.
Allison Cohen, M.D.
Salma Faghri, M.D.
Emily Goldenberg, M.D.
MEDICINE/PEDIATRICS
PGY-1
Melinda Biernacki, M.D.
Rachel Epstein, M.D.
44
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
RHODE ISLAND HOSPITAL/THE MIRIAM HOSPITAL
Post Graduate Plans: Categorical Internal Medicine (2008–2009)
CHIEF RESIDENCY
2009
Internal Medicine Residency, Alpert Medical School, Providence, RI
Internal Medicine Residency, Alpert Medical School, Providence, RI
Internal Medicine Residency, Alpert Medical School, Providence, RI
Internal Medicine Residency, Alpert Medical School, Providence, RI
2008
Internal Medicine Residency, Alpert Medical School, Providence, RI
Internal Medicine Residency, Alpert Medical School, Providence, RI
FELLOWSHIP PLACEMENT
Cardiovascular
2010
Alpert Medical School of Brown University, Providence, RI
Jefferson Medical College
2009
Alpert Medical School of Brown University, Providence, RI
Alpert Medical School of Brown University, Providence, RI (2010)
2008
Alpert Medical School of Brown University, Providence, RI
Washington University, St. Louis, MO
Washington Hospital Center, Washington, DC
University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School,
Endocrinology
2010
George Washington University, Washington, DC
Alpert Medical School of Brown University, Providence, RI
Lahey Clinic, Burlington, MA
2009
Stanford University, Stanford, CA (2010)
Alpert Medical School of Brown University, Providence, RI
Gastroenterology
2010
Ohio State University, Columbus, OH
State University of New York Stonybrook, Stonybrook, NY
2009
SUNY - Buffalo, Buffalo, NY
Albert Einstein, New York, NY
Lahey Clinic, Burlington, MA
University of North Carolina at Chapel Hill, Chapel Hill, NC (2010)
2008
Ohio State University, Columbus, OH
Oschner Clinic, New Orleans, LA
University of New Mexico (2009)
University of Florida, Gainesville, FL
Hematology-Oncology
2009
Mt. Sinai Medical Center, New York, NY (2010)
Duke University, Durham, NC (2010)
Yale University, New Haven, CT
Alpert Medical School of Brown University, Providence, RI (2010)
Alpert Medical School of Brown University, Providence, RI (2010)
2008
UCLA Medical Center, Los Angeles, CA
Tufts-NEMC, Boston, MA
Alpert Medical School of Brown University, Providence, RI
Alpert Medical School of Brown University, Providence, RI
45
gener al internal medicine
RHODE ISLAND HOSPITAL/THE MIRIAM HOSPITAL
Post Graduate Plans: Categorical Internal Medicine (2008–2009) continued
Infectious Disease
2008
University of North Carolina, Chapel Hill, NC
Northwestern, Chicago, IL (2009)
Nephrology
2009
University of California San Francisco, San Francisco, CA
Alpert Medical School of Brown University, Providence, RI
Albert Einstein College of Medicine, New York, NY
2008
Cornell University, Ithaca, NY
Cornell University, Ithaca, NY
University of Virginia, Charlottesville, VA
Alpert Medical School of Brown University, Providence, RI
Alpert Medical School of Brown University, Providence, RI
Palliative Care
2009
Harvard University, Cambridge, MA
Pulmonary Diseases & Critical Care Medicine
2009
University of Kansas, Kansas City, KS (2010)
Alpert Medical School of Brown University, Providence, RI
University of Virginia, Charlottesville, VA
New York University, New York, NY (2010)
Rheumatology
2009
Duke University, Durham, NC (2010)
Duke University, Durham, NC (2010)
2008
Roger Williams Medical Center, Providence, RI
Albert Einstein College of Medicine, NYC, NY
Medical Practice
2009
The Frist Clinic, Centennial Medical Center, Nashville, TN
2008
South Shore Medical Center, Norwell, MA
Private Practice, Chicopee, MA
Depage Internal Medicine, Carol Stream, IL
Internal Medicine Practice, Washington, DC
Academic Medical Practice
2009
Attending, Division of General Internal Medicine, RI Hospital
Hospitalist
2009
Salmon Creek Hospital, Legacy Health System, Vancouver, WA (assignment through Locums)
2009
Milford Reigional Medical Center, Milford, MA
2009
The Miriam Hospital, Providence, RI
2008
Rex Hospital, UNC, Chapel Hill, NC
Mayo Clinic, Rochester, NY
Wayne Memorial Hospital, Honesdale, PA
Research
2010
46
Investigator/Researcher, Centers for Disease Control, Atlanta, GA
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
RHODE ISLAND HOSPITAL/THE MIRIAM HOSPITAL
Post Graduate Plans: Primary Care (2008–2009)
CHIEF RESIDENCY
2009
Alpert Medical School Internal Medicine Residency, Providence, RI
2008
Alpert Medical School Internal Medicine Residency, Providence, RI
Alpert Medical School Internal Medicine Residency, Providence, RI
FELLOWSHIP PLACEMENT
Endocrinology
2009
Duke University, Durham, NC (2010)
2008
University of Vermont, Burlington, VT
Geriatrics
2008
Alpert Medical School of Brown Univeristy, Providence, RI
Geriatrics Palliative Care
2008
Duke University, Durham, NC
Infectous Diseases
2009
Alpert Medical School of Brown Univeristy, Providence, RI
Pulmonary Diseases & Critical Care Medicine
2009
Hospice and Palliative Care, Massachusetts General Hospital, Dana Farber Cancer Institute
and Brigham and Women’s Hospital, Boston, MA
Pulmonary/Critical Care Fellowship, New York University
Rheumatology
2009
Scripps Clinic, San Diego, CA
Medical Practice
2009
University Health Services, Penn State University, State College, PA
Lahey Clinic Medical Center, Burlington, MA
NYU / Murray Hill Medical Group, New York, NY
University Internal Medicine, Pawtucket, RI
Silver Healthcare, Silver City, NM
2008
Tufts Medical Center, Boston, MA
Academic Medical Practice
2009
Consultant/Instructor, Botswana-UPenn Partnership, Department of Infectious
2008
Attending, Division of General Internal Medicine, RI Hospital
Hospitalist
2009
The Miriam Hospital, Providence, RI
2008
Mt. Sinai Hospital, NY, NY
South Shore Hospital, Weymouth, MA
Northwestern, Chicago, IL
47
gener al internal medicine
RHODE ISLAND HOSPITAL
Post Graduate Plans: Medicine / Pediatrics
CHIEF RESIDENCY
2009
Pediatric Chief Resident, Habro Children’s Hospital, Providence, RI
2008
Internal Medicine Residency, Alpert Medical School, Providence, RI
FELLOWSHIP PLACEMENT
Hematology/Oncology
2008
St. Jude’s Children’s Research Hospital, Memphis, TN
Infectious Disease
2010
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston
2009
Stanford University, Stanford, CA (2010)
Pulmonary-Critical Care
2009
Pulmonary/Critical Care Fellowship, Alpert Medical School (2009)
Medical Practice
2009
University of Utah Community Clinics, Salt Lake City, UT
Academic Medical
2009
Faculty, Medicine/Pediatrics Clinic, University of Massachusetts, Westborough, MA
Pediatric Faculty, Moi UniversityHospital, Kenya
2008
Attending, Medicine/Pediatrics Primary Care Center
Resident Research Day Poster Competition
48
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
MEMORIAL HOSPITAL
Post Graduate Plans
CHIEF RESIDENCY
2008
Internal Medicine Residency, Memorial Hospital of Rhode
Island, Warren Alpert School of Medicine of Brown University
FELLOWSHIP PLACEMENT
Cardiovascular
2010
St. Elizabeth’s Medical Center, Tufts University School of Medicine, Worcester, MA
Geriatrics
2009
Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI
Nephrology
2010
Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI
Hematology-Oncology
2009
Roswell Park Cancer Institute, SUNY Buffalo School, Buffalo, NY
2008
St. Elizabeth’s Hospital, Tufts University School of Medicine, Worcester, MA
Nuclear Cardiology
2008
MA General Hospital, Harvard Medical School, Boston, MA
Pulmonary Diseases & Critical Care Medicine
2008
Rhode Island Hospital, Alpert Medical School of Medicineof Brown University, Providence, RI
Medical Practice
2009
Coastal Medical Center, East Providence, RI
St. Elizabeth’s Medical Center, Tufts University Schoolof Medicine, Worcester, MA
The Miriam Hospital, Providence, RI
The Miriam Hospital, Providence, RI
The Miriam Hospital, Providence, RI
Memorial Hospital of Rhode Island, Warren Alpert School of Medicine of Brown University,
Pawtucket, RI
Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI
Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI
The Miriam Hospital, Providence, RI
2008
Datrmouth-Hitchcock Clinic, Manchester, NH
Nardone Medical Associates, Inc., Pawtucket, RI
St. Elizabeth’s Hospital, Boston, MA
St. Vincents Hospital, Worcester, MA
Rhode Island Hospital, Warren Alpert School of Medicine of Brown University, Providence, RI
Hospitalist
2009
Milford Regional Medical Center, Milford, MA
49
g e r i at r i c s
GERIAT RIC S
OVERVIE W
T
he past two academic years have seen dynamic
change for the Division. Despite faculty turnover,
programs in clinical care, education and research
have continued to expand and mature. The Division has
been awarded a John A. Hartford Foundation Center
of Excellence in Geriatric Medicine and Training, in
support of career development for academic faculty geriatricians (July, 2008 – June, 2011, $450,000) – a major
objective for our Division. Five faculty members and
two advanced fellows receive support. The Donald W.
Reynolds project has completed 3 years of work (4 years,
$2 million) on establishing comprehensive programs to
strengthen physician education and training in geriatrics.
These two grants place the Division and Brown among
only 14 geriatrics programs nationally winning both
awards. All junior faculty members in the Division are
funded on one or the other of these grants, and 6 are on
both. Three Division faculty members applied for the
Federal Geriatric Academic Career Award in 2007 (Drs.
McMackin, McNicoll, and Tuya), and all three received
this 3-year career development grant. Rhode Island Hospital has funded the Division of Geriatrics to develop
and implement a comprehensive Palliative Medicine
Program for the hospital, in collaboration with Home
and Hospice Care of RI (HHCRI) – the largest notfor-profit hospice in the State, and already an important
partner of the Division in clinical care, education and
research related to end-of-life care. A fellowship in
Palliative Medicine is also under development. With
accreditation of the fellowship, the Division name will
change to Geriatrics and Palliative Medicine, in recognition of strong congruent programs. A comprehensive
clinical, educational and research program in Geriatrics
has been launched in collaboration with the Providence
VA Medical Center. New clinical relationships have been
established with another excellent nursing home (Tockwotton Home, Dr. Gravenstein is medical director),
joining our existing programs with the Steere House,
Epoch on Blackstone and Oak Hill facilities.
Stefan Gravenstein, M.D., MPH, was recruited as Associate Division Director in 2007. He previously was the
John Franklin Chair of Geriatrics, Professor of Medicine,
Director of the Division of Geriatrics and its Geriatrics Fellowship program, and Director of the Glennan
Center on Aging, all at Eastern Virginia Medical School.
He is an eminent scientist, teacher and clinician. His
50
Richard W. Besdine, M.D., Professor of Medicine
Director, Division of Geriatrics
primary roles include quality improvement work with
Quality Partners of RI, research and research mentoring, as well as participation in the cross-setting clinical
(RIH inpatient, assisted living and nursing home) and
educational programs of the Division. In 2009, Noel
Javier, M.D., MPH, was recruited as Assistant Professor
(clinician educator) from U Michigan, where he trained
in IM, Geriatrics and Palliative Medicine. He will work
in both Geriatrics and in the division’s growing focus
on palliative medicine, the latter in collaboration with
HHCRI. John Murphy, M.D., has been appointed Vice
President for Medical Affairs at RIH; he continues an
active geriatrics practice and mentoring fellows. Ana
Tuya Fulton, M.D. (teacher scholar track), recruited
from the fellowship to the faculty in 2006, was appointed Director of Medical Services at Butler Hospital
in 2007. She remains a member of the Division, and
continues her career development as a teacher scholar.
Ramona Rhodes, M.D., MPH (research scholar track),
Assistant Professor, also recruited from the fellowship
to the faculty in 2006, received a career development
award from the National Palliative Care Research Center
(7/09–6/11). David Dosa, M.D., MPH (research scholar
track), is co-PI on an NIH R01 award (2008) with Vince
Mor, Ph.D., to study emergency preparedness in nursing homes. Joan Teno, M.D., MS, an internationally
respected senior scientist, studies end-of-life care and is
Associate Medical Director for HHCRI; she is part time
a c a d e m i c y e a r s 20 08 a n d 20 09
in the Division. Naomi McMackin, M.D., recruited
in 2005 as lead geriatrician at Memorial Hospital of RI,
left our faculty in 2007 because of maternity and family
relocation. The Division mourns the tragic death of
long-time senior faculty member Tom Wachtel (6/09).
ACCO M PLI S H M EN T S
The prestigious Reynolds Foundation award has been
productive, both in geriatrics-related curriculum innovation for the medical school and for multiple residencies,
as well as in faculty development. Taking advantage
of concurrence with the major curriculum redesign in
the medical school that began in 2006, this project has
generated aging-related content for every relevant course
in every year for every student, and supplied examination questions on the material. More than 80 hours of
new aging-related content has been integrated into the
pre-clerkship curriculum of the first two years. Clinical
experiential goals in geriatrics have been established for
6 of 7 mandatory clinical clerkships, and themes across
the clerkships are being developed (end-of-life care
already deployed; transitions in care being discussed).
Multiple residencies have been enriched, especially Internal Medicine. A website is housed within the Medical
School’s curriculum site (Educational Resources on Aging [ERA]), with more than 125 separate learning objects
related to aging, including slide sets, curriculum content
outlines, examination questions, videos and articles to
support learners throughout the community. A Scholarly Concentration in Aging (SC-A) has been created
as one of 10 options. The SC program is a distinctive
feature of the curriculum redesign; it provides 1st year
students who enroll with a 3-year opportunity to do a
mentored project and have multiple enrichment experiences in broad topical areas, and aging served as the
prototype. Also supported by Reynolds is a specifically
tailored faculty development program for geriatricians,
created in collaboration with the Brown University
Sheridan Center for Teaching and Learning. Advanced
fellows and junior faculty (including nurse practitioners)
in the teacher scholar track enrolled in the Center’s year
1 program in 2007, and worked with Sheridan staff to
design a follow on geriatrics work group that has continued and enrolled additional trainees. Multiple posters,
abstracts and 2 scholarly papers have resulted from the
work, and the Sheridan Center is expanding its programs for faculty in clinical departments on the model
of the geriatrics initiative. Eleven fellows and faculty
have participated in the Sheridan Geriatrics Project.
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
The Hartford Center of Excellence award recognizes
and augments the Division’s fine record of recruiting
and training excellent fellows, who have ascended to
academic faculty positions here (Drs. Rhodes, Tuya Fulton), and at other institutions (Drs. Farrell, Blanchard).
Junior faculty members have gratifyingly gotten funding
and moved into leadership positions (Dr. Tuya Fulton
at Butler Hospital, Dr. Dosa at the VA). The ones who
leave and continue to prove their excellence also build
the Brown/RIH/UMF reputation.
The geriatric medicine fellowship program, accredited
in 2002, graduated its 12th, 13th and 14th fellows in
2009. Ten of the graduates since inception have gone
on to academic faculty careers in Geriatrics, and four
have pursued careers focused on clinical practice. Three
fellows committed to academic faculty careers entered
the program 7/09, and two current 1st years will do
a 2nd year of academic training. Other elite programs
have been able to recruit few or no fellows recently. A
goal that emerged during the 2008–09 academic year
has been to expand and enhance geriatrics programs at
TMH. Using the asset of the Fellowship Program, The
Miriam Hospital has developed and implemented a new
program in geriatrics - a formal clinical and educational
program in Geriatrics Hospitalist Medicine. Continuing
the tradition of hospital-wide excellence in care of older
patients (GENESIS, below), Kwame Dapaah Afriyie,
M.D., FACP, Chief of the Hospital Medicine Program
at TMH, and a formal lecturer in the Fellowship on
hospital care of older patients, joined his own expertise
in Geriatrics with that of the newly recruited former geriatrics fellow, Dr. Deepak Thiagarajan to create a formal
rotation that brings all Geriatric Medicine Fellows to
TMH for education in hospital care of elders. Residents
and medical students also have experience with the team.
At TMH, beginning in 2006, elderly in-patients from
Division of Geriatrics practices have been cared for
in collaboration with the Hospitalist Program. The
GENESIS project, begun in 2002 by Dr. McNicoll in
collaboration with Nursing, brought geriatrics strategies to the care of TMH patients. The project won the
Barnett Fain Quality Improvement Award for 2003.
GENESIS also won TMH’s Patient Satisfaction Award
2004. The division continues to participate in quality
improvement initiatives at TMH and RIH to improve
quality of care for older hospitalized patients. The Division Director serves on TMH’s Clinical Quality Council
and rounds twice monthly in the Professors Rounds
series for the residents.
51
g e r i at r i c s
The Geriatrics Program at the Providence VAMC
provides ambulatory primary care and interdisciplinary assessment for a panel of hundreds of elder veterans.
Clinical outcomes for this population are improving substantially, compared with previous care. Geriatrics fellows
and internal medicine residents learn geriatrics in this
setting. In addition, a health services research program
and junior faculty career development program are underway. Faculty positions in education, clinical care and
research are being supported, as well as geriatrics fellows.
Research productivity of the Division has been concentrated at the Center for Gerontology and Healthcare
Research on the Brown campus; the Division Director is
also Center Director. One of 10 centers comprising the
research arm of the Program in Public Health, the Gerontology Center is internationally respected for its studies
on health and healthcare of older persons. Research
activities of Drs. Besdine, Dosa, Gravenstein, Rhodes and
Teno occur primarily in the setting of the Center; productivity has increased substantially over the past two years in
spite of no new faculty additions. The Center’s 19 faculty
hold more than 40 active grants, including a $10 million
program project on nursing home quality and policies to
enhance the quality of that care (Vince Mor, PI). Of 51
proposals submitted in the past academic year (including
8 proposals for Recovery Act funding), 18 have been funded, 20 are still under review, and 13 were not funded. Two
stimulus grants totaling > $2 million have been awarded.
Important to the Center’s research success is the ability
to train and launch the careers of the next generation of
health services research scientists. The T32 post-doctoral
training grant in Health Services Research is in its 24th
year, (AHRQ), and is available, along with the Brown
MPH Program, to geriatrics fellows pursuing research
careers. This grant has trained 58 post-doctoral fellows to
date; 61% have received at least 1 NIH (R01, R03, K07)
or Foundation grant. Almost all (>85%) conduct health
services or policy research. Eleven have academic leadership roles. Three geriatrics fellows have graduated from
this program. A new development in the past two years
has been the emergence of education-related research as
an outgrowth of the Reynolds Grant. Drs. McNicoll and
Nanda, and several advanced fellows have presented and
published abstracts and papers from the work.
The Gerontology Center and Division of Geriatrics have
played major roles in the development of health services
research at the VA. Susan Allen, Deputy Director of
the Center, is Co-Director (Peter Friedmann, M.D.,
Director) for the Center for Integrating Psychosocial
and Health Services, funded by a Targeted Research
52
Enhancement Program (TREP) Award; she will continue in this role for the Research Enhancement Award
Program (REAP), the next step up in core funding for
further development of the VA Program.. Vince Mor
has chaired the Steering Committee for the TREP, and
Fox Wetle chairs the Steering Committee for the REAP –
both senior faculty in the Gerontology Center. Through
the TREP, Center faculty members have been independently funded by the VA (Amal Trivedi, M.D., MPH
– Career Development Award; Linda Resnik, Ph.D. –
Merit Award; Orna Intrator, Ph.D. – co-PI on a Merit
Award; David Dosa, M.D., MPH – CDA under review).
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Richard W. Besdine, M.D.
Stefan Gravenstein, M.D., MPH,
John B. Murphy, M.D.
Joan Teno, M.D.
Tom J. Wachtel, M.D.
Associate Professors
Robert Crausman, M.D.
David Gifford, M.D., MPH
Assistant Professors
David M. Dosa, M.D., MPH
Sam Maghuyop, M.D., RN
Edward Martin, M.D.
Lynn McNicoll, M.D.
Aman Nanda, M.D.,
Ana Tuya, M.D.
Ramona Rhodes, M.D., MPH
Clinical Faculty
(Hospital and Foundation Based)
Assistant Professors
Deepak Thiagarajan, M.D.
Noel Javier, M.D.
Faculty Transitions
Departed Facult y
Naomi McMackin, M.D.
New Facult y
Stefan Gravenstein, M.D., MPH, CM.D., Professor of
Medicine (2007)
Samuel Maghuyop, RN, M.D., Clinical Assistant
Professor (2008)
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
GERIATRIC MEDICINE FELLOWSHIP PROGRAM ◆ Fellows Enrolled 7/1/07–6/30/09
Fellows
Medical
School
Residency
Years
Trained
Enrolled
Geriatrics
Certified
Gary Blanchard
Tufts
Boston MA
Timothy Farrell
Present
Employment
St. Vincent
Hospital
Worcester, MA
1
7/08–6/09
Eligible
Staff Physician, St.
Vincent’s Hospital,
Worcestor MA
Clinical Asst. Prof
(geriatrics, EC)
U Mass
Worcestor MA
Brown Family
Medicine
2
7/07–6/09
Eligible
Assistant Professor of
Division of Geriatrics
University of Utah (EC)
Porpon
Rotjanapan
Mahidol
University
Thailand
Metro West Med
Center
Natick MA
IM
(Categorical)
2
7/07–6/09
2008
First Year Infectious
Disease Fellow,
University of Iowa
Hospitals & Clinics (EC)
Rebecca Starr
SUNYDownstate
Brown IM
(Categorical)
1
7/07–6/08
Eligible
Staff Physician, Elder
Service Plan, Cambridge
Healthe Alliance, MA
(CP-m)
Mia Tomas
U Philippine s
U CT IM
(Primary Care)
1
7/08–present
Eligible
2nd Year fellow (EC)
EC = Educator Clinician faculty career
CP-m = Clinical Practice with mentoring of students, residents or practicing physicians
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Richard W. Besdine, M.D.
Honors And Awards
◆◆
Visiting Professor, National Council for Research
(CNR) and University of Padova; Padova, Italy (2009)
◆◆
Best Doctors in America (Geriatrics, all editions)
◆◆
Scientific Delegate of American Geriatrics
Society to Italian Geriatrics Society (2009)
Invited Pr esentations
◆◆
Jack Merritt Visiting Professor, Yale Medical
School and St. Rafael’s Hospital 2008
◆◆
Medical Grand Rounds, Umass Medical School 2009
◆◆
Medical Grand Rounds, Massachusetts
General Hospital 2009
Schol arly Activities
◆◆
Reviewer for Aging Clinical and
Experimental Research
◆◆
Occasional reviewer NEJM, JAGS, JAMA
◆◆
Ad Hoc Review Panel GACA 2007
David M. Dosa, M.D., MPH
Honors And Awards
◆◆
Research Enhancement Award
Program (REAP) Scholar
◆◆
Hartford Foundation Scholar
Invited Pr esentations
◆◆
“Should I Stay or Should I Go: The Question of
Nursing Home Evacuation?” Invited Symposium
Presentation at 2009 Gerontological Society
of America Conference; Atlanta GA.
◆◆
“The Development of a Feeding Tube Insertion
Quality Indicator for Acute Care Hospitals amongst
Nursing Home Residents with Advanced Dementia.”
Invited Oral Presentation At 2008 American
Geriatrics Society Conference, Washington DC
Schol arly Activities
◆◆
Reviewer, J American Geriatrics Society, J
American Medical Director’s Association,
Aging Clinical and Experimental Research
◆◆
Reviewer, Geriatric Medicine, American
Board of Internal Medicine
◆◆
Study Section: HRSA Geriatrics Academic
Career Award, August 2007
53
g e r i at r i c s
Ana Tuya Fulton, M.D.
John Murphy, M.D.
Honors And Awards
Honors And Awards
◆◆
◆◆
Geriatric Academic Career Award
(GACA) from HRSA awarded 9/07.
◆◆
President-elect American Geriatrics Society, 2007
◆◆
President of American Geriatrics Society 5/08–5/09
Assistant Director to the Reynolds Foundation
Grant, July 06-July 08 (PI Besdine)
◆◆
Chairman of the Board, American
Geriatrics Society 5/09–10
Stefan Gravenstein, M.D., MPH
Honors And Awards
◆◆
◆◆
◆◆
Clinical Practice Guideline committees
(three different committees) for Infectious
Disease Society of America (influenza in
long-term care, fever, chemoprophylaxis)
Chair, Results Workgroup, national Advancing
Excellence Campaign, 2007-2009; and, since
2006, Member, Advancing Excellence in America’s
Nursing Homes Campaign Steering Committee
Best Doctors in America (Geriatrics)
Invited Pr esentations
◆◆
Boston University, Boston, MA at Gerontology
Center on Biology of Aging and Influenza, 2008
◆◆
Advancing Excellence Campaign, Washington, DC on
Campaign Results to Medicare QIO leadership 2009
Schol arly Activities
◆◆
Study section NIHAO2008-012: “Operation
of a Facility to Study Influenza Viruses,
Vaccines and Antimicrobials”. Thames
E. Pickett, Ph.D. Scientific Review Officer,
NIAID/NIH/DHHS, Reviewer. (2008).
Lynn McNicoll, M.D., FRCPC
Honors And Awards
◆◆
Best Doctors in America - 2007, 2008, 2009
Schol arly Activities
◆◆
Aman Nanda, M.D.
Honors And Awards
◆◆
Best Doctors in America 2007–2008,
2009-2010 Geriatric Medicine.
◆◆
Joint Organizing Secretary, International Congress on
Gerontology and Geriatric Medicine. India Institute
of Medical Sciences (AIIMS), New Delhi, India, 2009
Invited pr esentations
◆◆
Nanda A, Rachel R. Novel Program for Faculty
Development of Geriatrics Educator Clinicians.
Presented in Workshop on Model Geriatric
Programs: Geriatric Education Materials and
Methods Swap, AGS 2009 Annual Meeting
◆◆
Nanda A. “Using Narrative Journals to
Evaluate Integration of Geriatrics into
the Medical School Curriculum,” Paper
presentation, AGS 2009 Annual Meeting
◆◆
Nanda A, 3 presentations, International Congress on
Gerontology and Geriatric Medicine. India Institute
of Medical Sciences, 2009, New Delhi, India.
Schol arly Activities
◆◆
Reviewer, Annals of Long-Term Care, JAMA
◆◆
Question Reviewer for Geriatric Medicine,
American Board of Internal Medicine
Invited Pr esentations
◆◆
◆◆
Education Methods Swap Workshop Presentation
at the American Geriatrics Society Conference
– “Cadaver Treasure Hunt: Introducing Geriatrics
Concepts in the Anatomy Class” May 2009
Education Methods Swap Workshop Presentation
at the American Geriatrics Society Conference.
– “Novel Program for Faculty Development of
Geriatrics Educator Clinicians” May 2009.
Schol arly Activities
54
◆◆
Reviewer, J American Geriatrics Society
◆◆
Guest Editor – Health and Medicine
RI, August 2009 Issue
◆◆
Director, Scholarly Concentration in Aging
◆◆
Director of Education, Division of Geriatrics
◆◆
Leadership Member, RI ICU Collaborative
Reviewer, Family Medicine, J American
Board of Family Medicine
Tom Wachtel, M.D.
Schol arly Activities
◆◆
Reviewer - A J Medicine, Annals of Internal
Medicine, J General Internal Medicine, J
the American Geriatrics Society, JAMA,
New England Journal of Medicine
a c a d e m i c y e a r s 20 08 a n d 20 09
S ELEC T ED P U B LICAT ION S
Richard W. Besdine, M.D.
Tuya A, Besdine RW. Geriatrics for the Practicing
Physician: Using the Comprehensive Clinical
Approach to Older Patients. Medicine and Health
Rhode Island. January 2007; 90(1): 27–28.
◆◆
Gravenstein S, Besdine RW. From Occam’s
razor to multimorbidity: geriatrics comes of
age. Aging Clin Exp Res. 2008;20: 179–80.
◆◆
Shield RR, Wetle TF, Besdine RW. Preparing for
the silver tsunami: the integration of geriatrics
into the new medical curriculum at Alpert
Medical School of Brown University. Medicine
and Health Rhode Island. 2008; 91 (8): 247–9.
◆◆
◆◆
◆◆
Teno J, Dosa D, Rochon T, et al. Development of
Brief Survey to Measure Nursing Home Residents
Perceptions of Pain Management. Journal of Pain
and Symptom Management. 2008;36:572–583
Dosa D, Hyer K, Brown L, Artenstein A, PolivkaWest L, Mor V. The Controversy Inherent
in Managing Frail Nursing Home Residents
during Complex Hurricane Emergencies. J
Am Med Dir Assoc. 2008; 9:599–604.
◆◆
◆◆
◆◆
Tuya A, Besdine RW. Geriatrics for the Practicing
Physician: Using the Comprehensive Clinical
Approach to Older Patients. Medicine and Health
Rhode Island. January 2007; 90(1): 27–28.
Tuya A. Geriatrics for the Practicing Physician:
Managing the Medication Portfolio & Avoiding
Polypharmacy in the Older Adult. Medicine and
Health Rhode Island. February 2007; 90(2): 57–58.
◆◆
◆◆
Pop-Vicas A, Tacconelli AE, Gravenstein S, et
al. Influx of multidrug-resistant, gram-negative
bacteria in the hospital setting and the role of elderly
patients with bacterial bloodstream infection. Infect
Control Hosp Epidemiol 30(4): 325–31, 2009.
◆◆
Baier RR, Butterfield K, Patry G, Harris Y,
Gravenstein S. Identifying Star Performers:
The Relationship between Ambitious Targets
and Nursing Home Quality Improvement. J
Am Geriatr Soc 57, ePub Jun 22, 2009.
Nanda A, Bourbonniere M, Wetle T, Teno
J. Home care in the last year of life: Family
member perceptions of unmet need associated
with last place of care. JAMA, 2009, in press.
Ramona Rhodes, M.D., MPH
◆◆
◆◆
◆◆
Tuya A. Dysphagia. In: 5 Minute Clinical
Consult 2008. Lippincott Williams & Wilkins.
Stefan Gravenstein, M.D., MPH
Murphy JB, Hollman P. Response Letter to
Dr. Stefanacci et al. JAGS, 2009;57:1118.
Aman Nanda, M.D.
Ana Tuya Fulton, M.D.
◆◆
Original Article/Brief Methodological Report: Dosa
D, McNicoll L, Intrator O. Preliminary Derivation
of a Nursing Home Confusion Assessment
Method (NH-CAM) Based on Data from the
M.D.S. J Am Geriatr Soc 2007;55(7):1099–1105.
Baumhover L, McNicoll L. Providing a Geriatric
Friendly Environment for the Older Surgical
Patient. Nursing Clinics of North America;
Perioperative Nursing Clinics, 2007;2:309–316.
Editorial: Depalo V, McNicoll L. Spotlight
on Quality in Rhode Island. Medicine &
Health, Rhode Island. 2009;92(8):264.
John Murphy, M.D.
David M. Dosa, M.D., MPH
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Lynn McNicoll, M.D.
◆◆
◆◆
◆
Rhodes RL, Teno JM, Connor SR. African American
Bereaved Family Members’ Perceptions of the
Quality of Hospice Care: Lessened Disparities, but
Opportunities to Improve Remain. Journal of Pain
and Symptom Management. 2007;34:472–479.
Rhodes RL, Mitchell SL, Miller SC, Connor SR,
Teno JM. Bereaved Family Members’ Evaluation
of Hospice Care: What Factors Influence Overall
Satisfaction with Services? Journal of Pain and
Symptom Management. 2008;35:365–371.
Kuo S, Rhodes RL, Mitchell SL, Mor V, Teno
JM. National history of feeding tube use
in nursing home residents with advanced
dementia. Journal of the American Medical
Directors Association. 2009;10:264–270.
Joan Teno, M.D., MS
◆◆
◆◆
◆◆
Teno JM, Mitchell SL, Skinner J, Kuo S, Fisher
E, Intrator O, Rhodes R, Mor V. Churning:
the association between health care transitions
and feeding tube insertion for nursing home
residents with advanced cognitive impairment.
J Palliat Med. 2009 Apr;12(4):359–62.
Teno JM, Lima JC, Lyons KD. Cancer patient
assessment and reports of excellence: reliability and
validity of advanced cancer patient perceptions of the
quality of care. J Clin Oncol. 2009 Apr 1;27(10):1621–6.
Teno JM, Connor SR. Referring a patient and family
to high-quality palliative care at the close of life: “We
met a new personality… with this level of compassion
and empathy”.JAMA. 2009 Feb 11;301(6):651–9.
55
g e r i at r i c s
RESEARCH
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$0
$0
$0
$0
$0
$0
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$327,504
$310,183
$96,873
$34,888
$424,377
$345,071
research
Lynn McNicoll, M.D.
◆◆
Rhode Island Foundation, ICU Utilization
Among Nursing Home Residents
◆◆
Department of Health and Human Services/Health
Resources and Services Administration/Bureau of
Health Professions, Geriatric Academic Career Award
Richard Besdine, M.D.
◆◆
Reynolds Foundation, Mandatory Geriatrics
Education for Brown Medical School:
Comprehensive Curriculum Redesign
◆◆
Hartford Foundation, Center of Excellence in
Geriatric Medicine and Training At Brown
Ramona Rhodes, M.D.
◆◆
David Dosa, M.D.
56
◆◆
Veterans Administration, Medication Use as a
Quality Indicator in VA Nursing Home Care Units
◆◆
California Healthcare Foundation, Evaluation
of the “Reducing Potentially Preventable
Transfers at End of Life” Project
Brown University and National Institute
of Health, Use of Feeding Tubes Among
Person with Advanced Dementia
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DIVI S ION OF
HE M ATOLOGY/
ONCOLOGY
OVERVIE W
T
he combined Hematology/Oncology group at
Rhode Island Hospital and Miriam, and the
Warren Alpert Medical School at Brown University has progressed in its quest for excellence in clinical
care, education, and basic and clinical research. We have
welcomed three new M.D. faculty members: Drs. David
Berz, Jorge Castillo, and Angela Plette, and Dr. Ravi
Krishnadasan departed for Arizona.
Dr. Howard Safran has assumed leadership of BrUOG
and the clinical research group, and exciting new protocols have been initiated with increasing accrual rates.
A clinical Translational Research Program around
cancer microvesicles and their ability to change the
phenotype of normal cells has been initiated and
resulted in a number of abstracts on breast, prostate,
and lung cancer, and one small grant to Dr. Renzulli.
Manuscripts are now in preparation.
Peter J. Quesenberry, M.D., Professor of Medicine
Director, Division of Hematology/Oncology
The Division now has a total of 7 Nurse Practitioners or
Physician Assistants supporting the clinical operation.
They have had an impressive impact.
Dr. James Butera continues to establish his Hematological Malignancies Section, and the Wednesday meetings
have been a success.
Educational activities have continued to be emphasized
with Dr. Mary Anne Fenton leading the Curriculum
Committee and the efforts to establish a full set of SOPs
for Hematology/Oncology.
Dr. Tony Mega has led the establishment of a Multidisciplinary Urology Clinic between Miriam and RIH.
The Fellowship Program under Dr. Anthony Mega
continues to provide excellent clinical teaching and has
been expanding as to the research venues offered.
We have continued to work towards the establishment
of a stem cell transplant unit. Negotiations with Roger
Williams have led to agreements to establish a combined
transplant operation with an independent but cooperative unit at both Rhode Island Hospital and Hasbro.
Clinical activity has continued to grow with an estimated 15% increase at both institutions.
A new inpatient service has begun at Miriam with Fellow and Nurse Practitioner involvement and an emphasis on teaching. It has proved to be a real success.
We have been awarded two COBRE grants. Doug Hixson is PI on one, and Peter Quesenberry is PI on the
other. This provides infrastructure and research funding,
and amounts to over 20 million total dollars over the
next 5 years.
Plans are now proceeding for renovations of our
research space in Coro, which will be carried out in
a 2 phase operation.
Plans for further recruitment are in development.
57
h e m at o l o g y / o n c o l o g y
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Jason Aliotta, M.D.
Professors
Douglas Hixson, Ph.D.
Djuro Josic, Ph.D.
Peter J. Quesenberry, M.D.
Fred Schiffman, M.D.
Honors And Awards
Associate Professors
Loren Fast, Ph.D.
Edward Filardo, Ph.D.
Howard Safran, M.D.
Edward Wittels, M.D.
Assistant Professors
Jason Aliotta, M.D.
David Berz, M.D.
Jorge Castillo, M.D.
Devasis Chatterjee, Ph.D.
Humera Khurshid, M.D.
David Mills, Ph.D.
Angela Plette, M.D
Eric Winer, M.D.
Clinical Faculty
(Hospital and Foundation Based)
Associate Professors
Anthony Mega, M.D.
Assistant Professors
Ariel Birnbaum, M.D.
James Butera, M.D.
Maria Constantinou, M.D.
Mary Anne Fenton, M.D.
Iole Ribizzi-Akhtar, M.D.
William Sikov, M.D.
Rochelle Strenger, M.D.
Anthony Thomas, D.O.
Sabrina Witherby, M.D.
◆◆
Elected Fellow of the American College
of Chest Physicians (FCCP) 2008.
Invited Pr esentations
◆◆
“Tissue specific gene expression of marrow cells
co-cultured with various murine organs” at
the American Society of Hematology (ASH)
2008 Annual Meeting in San Francisco, CA.
◆◆
“The lung and bone marrow: Microvesicles and their
role in cellular communication” at the Experimental
Biology conference 2009 in New Orleans, LA.
R esearch & Schol arly Activities
◆◆
The Warren Alpert Medical School of Brown
University Pulmonary Research, Seminar
Series Co-Chair, 7/05–present.
James Butera, M.D.
Honors And Awards
◆◆
Top Doctor, RI Monthly Magazine, May 2008.
Schol arly Activities
◆◆
Journal Reviewer for Experimental Hematology
◆◆
University of Medicine Foundation,
Board of Trustees, 2008–2009
◆◆
Chair of Hematologic Malignancies
Committee, BrUOG Department of
Hematology/Oncology, 2008, 2009.
◆◆
RIH Translational Research Committee, 2008–09
◆◆
RIH Residents Meeting Group Committee, 2008, 2009
◆◆
RIH Hematology/Oncology Curriculum
Committee, 2008, 2009
◆◆
RIH Chief, Hematology Malignancy Section/
Conference Director, weekly conference, 2008, 2009
◆◆
Tumor Board Director, Rhode Island
Hospital weekly conference, 2008, 2009
Volunteer Clinical Faculty
Jorge Castillo, M.D.
Associate Professors
Nancy Freeman, M.D.
Invited Pr esentations
Assistant Professors
Linda Hassan, M.D.
Plakyil Joseph, M.D.
Ahmed Nadeem, M.D.
Sundaresan Sambandam, M.D.
Instructors
Anthony Testa, M.D.
58
S ELEC T ED HONOR S
AND S CHOLARLY W OR K :
◆◆
Non-Hodgkin’s’ Lymphoma, Metro
West Medical Center, 2008.
◆◆
Hematopoietic Stem Cell Transplantation Professor
Rounds, Metro West Medical Center, 2008.
Schol arly Activities
◆◆
Principal Investigator, Phase II trial of
Ofatumumab and Bortezomib for patients with
low grade B-cell lymphoproliferative disorders
that relapse after Rituximab, BrUOG 2009.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
◆◆
Ad hoc Reviewer. The Molecular Profile of Oral
Plasmatiastic Lymphomas in a South African
population sample. National Health Laboratory
Service Research Trust Grants, South Africa, 2009.
Sentinel reader. McMaster online rating of evidence
(MORE) Program, McMaster University, 2009.
Devasis Chatterjee, Ph.D.
Invited Pr esentations
◆◆
“Induction of Raf-1 kinase inhibitory protein (RKIP)
by the proteasome inhibitor NPI-0052 and reversal of
B-NHL resistance to apoptosis”, American Society of
Hematology (ASH) Annual Meeting, December 2007.
◆◆
“Inhibition of small-induced EMT and induction
of the tumor metastasis suppressor/immune cancer
gene RKIP by the proteasome inhibitor NPI-0052:
roles in metastasis and chemo/immunosensitization”.
Proc Am Assoc Cancer Research, April 2008.
◆◆
“Inhibition of STAT3 activation by RKIP in
breast cancer. D.O.D Breast Cancer Research
Era to Hope Meeting, June 2008.
◆◆
“Helicobacter pylon inhibits RKIP function via
STAT3 activation and small induction in human
gastric cancer cells. DDW meeting, May 2009.
Schol arly Activities
◆◆
Ad hoc reviewer for clinical cancer research
◆◆
Ad hoc reviewer for expert opinion
on investigational drugs
◆◆
Ad hoc reviewer for Journal of Clinical Investigation
◆◆
Ad hoc reviewer for Journal of Immunology
◆◆
COBRE CCRD NIH/NCRR Junior Investigator.
◆◆
Mentor for Brown University Bio 195/196 Senior
Honors. UTRA, PLME/SRA, and Leadership
Alliance Programs. Cancer Research Program.
Gerald Colvin, D.O.
Honors And Awards
◆◆
American Medical Association
Physicians Recognition Award.
Invited Pr esentations
◆◆
“HIV related malignancies”, Moi University
Hospital, Kenya, July 2008.
◆◆
“Breast Cancer, AMPATH Symposium, El
Doret, Kenya, September 2008.
Edward Filardo, Ph.D.
Invited Pr esentations
◆◆
Invited Speaker: “Cell biological actions promoted
by the membrane estrogen receptor GPR30”,
Michigan State University, Department of
Physiology, East Lansing, MI. January 30, 2008.
◆◆
Invited Speaker: “GPR30 and regulation of membrane
estrogen action”. FASEB Conference. “Extra-Nuclear
Steroid Receptors: Integration with Multiple Signaling
Pathways”, Carefree, AZ, July 27–August 1, 2008.
◆◆
Invited Speaker: “Biological role of the seven
membrane estrogen receptor, GPR30/GPER1 in breast cancer”. Mayo Clinic Breast Cancer
SPORE Scientific Symposium, October 2, 2008.
Schol arly Activities
◆◆
Ad hoc reviewer for Breast Cancer Research and
Treatment Cancer Research Endocrinology
◆◆
Ad hoc reviewer for J Neurochemistry
◆◆
Ad hoc reviewer for Journal of Neuroscience
◆◆
Ad hoc reviewer for Journal of Steroid
Biochemistry & Molecular Biology
◆◆
Ad hoc reviewer for Nature /Cell Signaling
◆◆
Study Section for National Science Foundation.
◆◆
Komen Foundation for Breast Cancer Research,
Endocrine Therapies, Washington, DC,
November 20–21, 2008 Study Section.
Douglas Hixson, Ph.D.
Invited Pr esentations
◆◆
“Modern trends in human leukemia”, Wilsede, Germany.
Schol arly Activities
◆◆
Invited member of the Emerging Leaders Task Force.
◆◆
Cancer Center Protocol Review Committee.
◆◆
Cancer and Leukemia Group B Member (CALGB)
◆◆
Guest Lecturer, Immunology Medical
Microbiology BI254A, Pfizer Laboratories.
“Maturation events of precancerous cells”, the
Henry M. and Lillian Stratton Basic Research
Single Topic Conference, Pathobiology of Biliary,
Epithelial, and Cholangiocarcinoma, Emory
Conference Center, Atlanta, GA, 2008.
Schol arly Activities
◆◆
Director of Molecular Carcinogenesis
Laboratory, Department of Medicine, Division of
Hematology/Oncology, Rhode Island Hospital.
◆◆
Director, COBRE Center for Cancer Research
Development, Department of Medicine, Division
of Hematology/Oncology, Rhode Island Hospital.
◆◆
RIH Member, Search Committee,
Cancer Center Director.
Loren Fast, Ph.D.
Invited Pr esentations
j u ly 1 , 20 07 – j u n e 30 , 20 09
Mary Ann Fenton, M.D.
Invited Pr esentations
◆◆
◆
59
h e m at o l o g y / o n c o l o g y
◆◆
RIH Interview for Search Committee,
Chief of Hematology/Oncology.
◆◆
RIH Medical Faculty Executive Chairman.
◆◆
Symposium Cancer Research: The
Lighthouse of Hope, Providence, RI.
◆◆
Co-Chair, COBRE Stem Cell and Cancer
Therapeutics Symposium, Rhode Island
Convention Center, Providence, RI.
◆◆
Building and Supporting the Biotech Infrastructure
in Rhode Island: The Best of Times, The Worst of
Times, Executive Luncheon with Senior Managing
Directors of the Slater Technology Fund and the
Tech Collective/Biogroup, the Congressional
Delegation, CEOs of Brown University affiliated
Hospitals, Brown University Administrators,
Directors of the 4 Rhode Island COBRE Centers,
Department Chairs. Purpose: To identify the key
strategic initiatives needed to meet the challenges
facing biotechnology in Rhode Island and the role
of the COBRE Centers in meeting these needs.
David Mills, Ph.D.
Schol arly Activities
◆◆
Peter J. Quesenberry, M.D.
Honors And Awards
◆◆
Lifetime Achievement Award from Leukemia/
Lymphoma Society of America.
Invited Pr esentations
◆◆
“New stem cell models and transplant approaches.
Eighth International Symposium, Munich, Germany.
◆◆
“Stem cell models: lability of stem cell
and niche phenotypes. Goldsmiths
College, University of London, UK.
Schol arly Activities
◆◆
The Leukemia/Lymphoma Society, Translational
Research Program, New York City, NY.
◆◆
Regional Editor, Forum.
Djuro Josic, Ph.D.
◆◆
Section Editor, Leukemia.
Invited Pr esentation
◆◆
Editor, Central European Journal of Biology (CEJB).
◆◆
◆◆
◆◆
◆◆
◆◆
“Proteomics as a tool for optimization of human
plasma protein separation, ISPPP, Orlando, FL, 2008.
◆◆
Editorial Board, American Journal of Hematology.
◆◆
Associate Editor, Experimental Hematology.
“Identification of medium and low abundant proteins
in human plasma after chromatographic and
electrophoretic fractionation. Monolith Summer
School & Symposium, Portoroz, Slovenia, 2008.
◆◆
Lead Reviewer, Stem Cells.
“Investigation of secretomics from human prostate
cell line.” The University of Texas, M.D. Anderson
Cancer Center, Department of Molecular
Pathology Lecture Series, Houston, TX, 2008.
“Application of a new anion exchange resin for
chromatographic separation of human plasma.
Recovery conference, Quebec, Canada, 2008.
“Proteomics as a tool for optimization of
human plasma protein separation symposium.
Monoliths, Portoroz, Slovenia, 2008.
Schol arly Activities
◆◆
Head of the Proteomics Core, COBRE Center for
Cancer Research Development grant, NIH/NCRR.
Anthony Mega, M.D.
Honors And Awards
◆◆
Howard Safran, M.D.
Invited Pr esentations
◆◆
◆◆
◆◆
NCI GI Cancer Steering Committee and
Esophageal and Pancreatic Task Forces.
◆◆
RTOG Medical Oncology GI Chair.
◆◆
GI Oncology Editor of Up-to-Date.
◆◆
Medical Oncology Chair of Phase III
Adjuvant Pancreatic Cancer Trial.
Fred Schiffman, M.D.
Honors And Awards
◆◆
Selected Marshall, The Warren Alpert Medical School
of Brown University Commencement Exercises, 2008.
◆◆
Community Partnership Award presented
by The Rhode Island Department of Health
(HEALTH) for providing expert consultation
and assistance to the Board of Medical Licensure
and Discipline in caring and referring oncology
patients displaced by a physician, 2008.
◆◆
Appointed faculty advisor of the Gold Humanism
Honor Society Chapter at The Warren Alpert
Medical School of Brown University, 2008.
The Riesman Family Excellence
in Teaching Award, 2008.
“Managing men with castrate resistant
prostate cancer, Grand Rounds, Jordan
Hospital, Plymouth, MA, 2008.
“Targeted therapy in esophageal cancer.
Plenary presentation at ASCO GI.
Schol arly Activities
Invited Pr esentations
60
Member of the Lifespan Recombinant
DNA Committee.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
Selected by the Warren Alpert Medical School
of Brown University Class of 2009 to deliver
the Faculty Commencement address, 2009.
◆◆
◆◆
◆◆
◆◆
Edward Wittels, M.D.
Honors And Awards
“Advancing your academic agenda as a chief
resident association of program directors of
internal medicine” New Orleans, LA, 2008.
Dean’s Teaching Excellence Award, BIOL 3570
Integrative Medical Sciences IV Hematology, Warren
Alpert Medical School, Brown University, 2008.
◆◆
Workshop Leader: “Morning Report”,
Association of Program Directors of Internal
Medicine, San Diego, CA, 2008.
Dean’s teaching Excellence Award (BIOL 3672)
Integrative Medical Sciences IV Hematology,
Warren Alpert Medical School 2009.
◆◆
The Seventh Annual Department of Medicine Beckwith
Family Award for Outstanding Teaching, Warren
Alpert Medical School of Brown University, 2008.
Workshop leader, “Morning report”,
Association of Program Directors of
Internal Medicine, Dallas, TX 2009.
Chiefs of Medicine of Federation of
Jewish Philanthropies Hospitals Annual
Meeting. “Spirituality and patient care in the
modern hospital. Phoenix, AZ, 2008.
Chiefs of Medicine of Federation of Jewish
Philanthropies Hospitals Annual Meeting, Tucson,
AZ. Presentations entitled: “Development of the
Lifespan/Brown Cancer Center” and “Development
of the Teaching Police Department Initiative”. The
Gold Humanism Honor Society at The Warren
Alpert Medical School of Brown University, 2009.
Schol arly Activities
◆◆
Secretary, Board of Directors, The Miriam
Independent Physicians Association.
◆◆
Finance Committee, University Medicine Foundation.
◆◆
Investment Committee, University
Medicine Foundation.
◆◆
Clinical Operations Strategic Committee,
University Medicine Foundation.
◆◆
Chairman, Cancer Control Committee.
◆◆
Department of Medicine Teaching
Incentive Committee.
◆◆
Search Committee, Physician, Division of
Hematology/Oncology, The Miriam Hospital.
Schol arly Activities
◆◆
Visiting Professorship Baylor University,
Dallas, TX. Delivered Grand Rounds
and other lectures. March 2009.
William Sikov, M.D.
Honors And Awards
◆◆
S ELEC T ED P U B LICAT ION S
Jason Aliotta, M.D.
◆◆
Aliotta JM, Sanchez-Guijo FM, Dooner GJ,
Johnson KW, Dooner MS, Greer KA, Greer D,
Pimentel J, Kolankiewicz LM, Puente N, Faradyan
S, Ferland P, Bearer EL, Passero MA, Abedi
M, Colvin GA, Quesenberry PJ: Alteration of
marrow cell gene expression, protein production
and engraftment into lung by lung-derived
microvesicles: A novel mechanism for phenotype
modulation. Stem Cells 25(9):2245–56, 2007.
◆◆
Dooner MS , Aliotta JM, Pimentel J, Dooner
GJ, Abedi M, Colvin GA, Liu Q, Weier HU,
Johnson KW, Quesenberry PJ: Cell cycle related
differentiation of bone marrow cells into lung
cells. Stem Cell Dev 17(2):207–20, 2008.
◆◆
Aliotta JM, Keaney PJ, Warburton RR, Del Tatto M,
Dooner MS, Passero MA, Quesenberry PJ, Klinger JR:
Marrow cell infusion attenuates vascular remodeling in
a murine model of monocrotaline-induced pulmonary
hypertension. Stem Cell Dev 18(5):773–82, 2009.
Reviewer for Susan G. Komen for the Cure
Foundation Promise Grants, 2008.
Invited Pr esentations
◆◆
Overview of early breast cancer. Emerging trends from
randomized studies. Latin America Breast Cancer
Regional Medical Conference. Quito, Ecuador, 2008.
◆◆
Current treatment options for advanced
breast cancer, Medical University of South
Carolina, Hollings Cancer Center Medical
Grand Rounds, Charleston, SC 2007.
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Invited Pr esentations
◆◆
◆
Current treatment options for advanced breast
cancer. New England Medical Center, Hematology/
Oncology grand rounds, Boston, MA, 2008.
Rochelle Strenger, M.D.
Honors And Awards
◆◆
First annual Adele R. Decof Rose Award
for patient centered excellence.
◆◆
Co-Director of ACOS recognized,
Miriam Hospital Breast Center.
61
h e m at o l o g y / o n c o l o g y
HEMATOLOGY/ONCOLOGY FELLOWSHIP PROGRAMS
Anthony Mega, M.D., Director
Angela Plette, M.D., Associate Director
Graduates 2007:
Fellow
Medical School
Residency Program
Post-Fellowship Position
David Benton, M.D.
University of CT
Farmington, CT
Brown University/ Rhode
Island Hospital Providence, RI
Maine Center for Cancer
Medicine New Brunswick, ME
Devon Evans, M.D.
Jefferson Medical College
Philadelphia, PA
Beth Israel Deaconess
Medical Center Boston, MA
Maine Center for Cancer
Medicine New Brunswick, ME
Tirrell Johnson, M.D.
University of Florida College
Gainesville, FL
Orlando Regional Medical
Center Orlando, FL
Orlando Regional Health
System Orlando, FL
Neil Zakai, M.D.
University of Virginia
Charlottesville, VA
University of Vermont
Burlington, VT
University of Vermont
Burlington, VT
Fellow
Medical School
Residency Program
Post-Fellowship Position
David Berz, M.D., Ph.D., MPH
Humboldt University
Frankfurt, Germany
Yale University
New Haven CT
Rhode Island Hospital
Providence, RI
Jorge Castillo, M.D.
Universidad Autonoma
Metropolitana
Mexico City, Mexico
Metro West Medical Center
Framingham, MA
The Miriam Hospital
Providence, RI
Ellen Chirichella, M.D.
Jefferson Medical College
Philadelphia, PA
Brown University/Rhode
Island Hospital
The Doctors Clinic
Bremerton, WA
Hannah Hebert, D.O.
University of New England
College of Osteopathic
Biddeford, ME
Roger Williams Medical
Center
Providence, RI
UMASS Memorial Medical
Center
Worcester, MA
Michael McKenna, M.D.
UM.D.NJ – New Jersey
Medical School
Newark, NJ
Brown University/Rhode
Island Hospital
Providence, RI
Pennisula Cancer Institute
Riverside Regional Medical
Center
Newport News, VA
Fellow
Medical School
Residency Program
Post-Fellowship Position
Meredith Faggen, M.D.
Tulane University
New Orleans, LA
Yale University
New Haven, CT
Harbor Medical Associates
South Weymouth, MA
Brendan McNulty, M.D.
University of Massachusetts
Worcester, MA
Beth Israel Deaconess
Medical Center
Boston, MA
Milford Regional Medical
Center
Milford, MA
Angela Plette, M.D.
University of Massachusetts
Worcester, MA
Brown University/Rhode
Island Hospital
Providence, RI
Brown University/Rhode
Island Hospital
Providence, RI
Elliott J. Anderson, M.D.
Albany Medical College
Albany, NY
Brown University/Rhode
Island Hospital
Providence, RI
Hawthorne Medical
Associates
Dartmouth, MA
Lisa Manera, M.D.
Tufts University
Boston, MA
Caritas St. Elizabeth’s
Medical Center
Boston, MA
Harbor Medical Associates
South Weymouth, MA
Graduates 2008:
Graduates 2009:
62
a c a d e m i c y e a r s 20 08 a n d 20 09
James Butera, M.D.
◆◆
Quesenberry PJ, Butera JN: An interesting fishing
expedition. Cancer Biol Ther 8(4):338–9, 2009.
◆◆
Shipley, J, Butera J: “Acute Myelogenous
Leukemia”, Exp Hematol.
◆◆
Hebert HD, Butera JN, Castillo J, Mega A: Are we
training our fellows adequately in delivering bad
news to patients? A survey of Hematology/Oncology
Program Directors. J Pal Med, in press 2009.
◆◆
◆◆
Castillo J, Milani C, Mendez D: Ofatumumab,
a second-generation anti-CD20 monoclonal
antibody for the treatment of lymphoproliferative
and autoimmune disorders. Expert Opinion in
Investigational Drugs 18(4): 491–500, 2009.
Mitri J, Castillo J, Pittas A: Diabetes and risk of nonHodgkin lymphoma: A meta-analysis of observational
studies. Diabetes Care 31(12): 2391–2397, 2008.
Castillo J, Hansen C, Mega A, Tashima
K: AIDS-related lymphomas: The Rhode
Island Experience. Medicine & Health
Rhode Island 91(11): 332–334, 2008.
Devasis Chatterjee, Ph.D.
◆◆
Chatterjee D, Graeber CT, Wang JL, Darnowski JW,
Pisano C, Chin EC: Inhibition of STAT3 activation
by the campothecin analog ST2617 in human cancer
cells. Proc Amer Assoc Cancer Res 48:766, 2007.
◆◆
Chatterjee D, Doan M, Graeber C, Pisano C,
Chin YE: Targeting Stat3 with camptothecin:
A novel chemotherapeutic strategy. Proc
Amer Assoc Cancer Res 49:251, 2008.
◆◆
Chatterjee D, Sabo E, Tavares R, Resnick MB: Inverse
association between RKIP and STAT3 expression in
gastric adenocarcinoma patients: Implications for
clinical outcome. Clin Cancer Res 14:2994–3001, 2008.
◆◆
◆◆
Dooner GJ, Colvin GA, Dooner MS, Johnson
KW, Quesenberry PJ: Gene expression fluctuations
in murine hematopoietic stem cells with cell cycle
progression. J Cell Physiol 214(3):786–95, 2008.
Colvin GA, Berz D, Ramanathan M, Winer ES, Fast
L, Elfenbein GJ, Quesenberry PJ: Nonengraftment
haploidentical cellular immunotherapy for refractory
malignancies: tumor responses without chimerism.
Biol Blood Marrow Transplant 15(4):421–31, 2009.
Milani C, Constantinou M, Berz D, Butera JN,
Colvin GA: Left sided inferior vena cava duplication
and venous thromboembolism: case report and
review of literature. J Hematol Oncol 1:24, 2008.
Loren D. Fast, Ph.D.
◆◆
Rucevic J, Fast LD, Jay GD, Trespalcios FM,
Sucov A, Siryaporn E, Lim Y-P: Altered levels
and molecular forms of granzyme K in plasma
from septic patients. Shock 27:488–493, 2007.
Edward J. Filardo, Ph.D.
◆◆
Filardo EJ, Quinn JA, Sabo E: Association of the
membrane estrogen receptor, GPR30, with breast
tumor metastasis and transactivation of the epidermal
growth factor receptor. Steroids. 73(9-10):870–3, 2008.
Djuro Josic, Ph.D.
◆◆
Roser M, Josic D, Kontou M, Mosetter K, Maurer
P, Reutter W: Metabolism of galagtose in the
brain and liver of rats and its conversion and
its conversion into glutamate and other amino
acids. J Neural Transm 116(2):131–9, 2008.
Anthony Mega, M.D.
◆◆
Rizack T, Mega A, Legare R, Castillo J:
Management of hematological malignancies during
pregnancy. Am J Hematol 84(12):830–41, 2009.
David R. Mills, Ph.D.
◆◆
Mills DR, Haskell M.D., Callanan HM, Flanagan
DL, Brilliant KE, Yang DQ, Hixson DC. Monoclonal
antibody to novel cell surface epitope on Hsc70
promotes morphogenesis of bile ducts in newborn
rat liver. In press, Cell Stress and Chaperones 2009.
◆◆
Brilliant KE, Mills DR, Callanan HM, Hixson
DC. Engraftment of syngeneic and allogeneic
endothelial cells, hepatocytes and cholangiocytes into
partially hepatectomized rats previously treated with
mitomycin C. Transplantation 88(4):486–95, 2009.
Gerald Colvin, D.O.
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Maria Constantinou, M.D.
Jorge Castillo, M.D.
◆◆
◆
Peter J. Quesenberry, M.D.
◆◆
Quesenberry PJ, Dooner GJ, DelTatto M, Aliotta JM,
Colvin GA, Johnson KW, Dooner MS: Expression
of cell cycle related genes with cytokine-induced
cell cycle progression of primitive hematopoietic
stem cells. Stem Cells Dev. In press, 2009.
◆◆
Quesenberry PJ, Butera JN: An interesting fishing
expedition. Cancer Biol Ther 8(4):338–9, 2009.
◆◆
Quesenberry PJ: Stem cell plasticity: clinical
implications. Exp Hematol 36(6):669–71, 2008.
63
h e m at o l o g y / o n c o l o g y
Howard Safran, M.D.
◆◆
William M. Sikov, M.D.
Safran H, Miner T, Resnick M, Dipetrillo T,
McNulty B, Evans D, Joseph P, Plette A, Millis
R, Sears D, Gutman N, Kennedy T: Lapatinib/
gemcitabine and lapatinib/gemcitabine/oxaliplatin:
a phase I study for advanced pancreaticobiliary
cancer. Am J Clin Oncol 31(2):140–4, 2008.
◆◆
Berz D, Sikov W, Colvin G, Weitzen S:
‘Weighing in’ on screening mammography.
Breast Cancer Res Treat. 114(3):569–74, 2009.
◆◆
Sikov WM, Dizon DS, Strenger R, Legare RD,
Theall KP, Graves TA, Gass JS, Kennedy TA, Fenton
MA: Frequent pathologic complete responses in
aggressive stage II-III breast cancers with q4week
carboplatin and weekly paclitaxel + trastuzumab:
a Brown University Oncology Group study.
Accepted for publication, J Clin Oncol, 2009.
RESEARCH
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$2,793,251
$2,218,513
$468,821
$483,189
$3,262,072
$2,711,703
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$1,216,932
$918,530
$151,119
$73,013
$1,368,051
$991,543
S ELEC T ED
B A S IC RE S EARCH
Jason Aliotta, M.D.
◆◆
Injured Lung and its Influence on Bone Marrow Cell
Phenotype, National Heart, Lung, and Blood Institute
Devasis Chatterjee, Ph.D.
◆◆
Inhibition of STAT3 Signaling by RKIP in
Breast Cancer, Department of Defense
◆◆
Evaluation of RKIP as an anti-Oncogene in
Breast Cancer, Department of Defense
◆◆
Characterization of RKIP Expression in Human
Cancers, National Center for Research Resources
Gerald Colvin, D.O.
◆◆
Stem/Progenitor Cell Inversions With Cell
Cycle Transit, National Institute for Diabetes
and Digestive and Kidney Diseases
◆◆
Genesis of Liver Carcinomas with Oval
Cell Traits, National Cancer Institute
Djuro Josic, Ph.D.
◆◆
Ultraspec III TOF/TOF 200 MALDITOF Mass Spectrometry Imaging System,
National Center for Research Resources
Yow-Pin Lim, M.D.
◆◆
Inter-alpha Inhibitors in Neonatal Sepsis, National
Institute of Child Health and Development
Peter J. Quesenberry, M.D.
◆◆
Hematopoietic Circadian Rhythms, National Institute
for Diabetes and Digestive and Kidney Diseases
◆◆
Cell Cycle Related Transdifferentiation into Lung
Cells, National Heart, Lung, and Blood Institute
◆◆
Stem Cell Biology: New Directions in Clinical and
Basic Research, National Center for Research Resources
Edward Filardo, Ph.D.
◆◆
Study of GRP30: A Novel Estrogen Receptor Linked
to Breast Cancer, National Cancer Institute
◆◆
Assessment of GPR30, A Seven-TransmembraneSpanning Estrogen Receptor, as an
Oncogene, Department of Defense
Douglas Hixon, Ph.D.
64
◆◆
COBRE Center for Cancer Research Development,
National Center for Research Resources
◆◆
Cellular Origins of Liver Cancer,
National Cancer Institute
S ELEC T ED
CLINICAL RE S EARCH
Howard Safran, M.D.
◆◆
Radiation Therapy Oncology Group
William Sikov, M.D.
◆◆
Cancer and Leukemia Group B (CALGB),
University of Chicago/CALGB Foundation
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
HO S PI TALI S T
PROGRA M
RHODE I S LAND HO S PI TAL
OVERVIE W
R
hode Island’s first inpatient group inaugurated
on August 7, 1996. This was a ground breaking
move especially given the fact that the term
‘hospitalist’ had not yet been coined. The program,
originally under the Division of General Internal Medicine, began modestly with three full time physicians.
Initially, the role of the inpatient group was to cultivate
relationships with community physicians and a marketing campaign was launched. A patient brochure was
designed to provide an explanation to patients about
the new Internal Medicine Inpatient Service (hereby
designated as IMIS). Physicians were invited to sign up
with this new program that provided inpatient care to
their patients giving them the advantage of remaining in
their offices as opposed to making a hospital visit. The
IMIS program established formal links with the patients
Primary Care Physicians. Communication was established at the time of admission and discharge via fax or
phone call; discharge summaries sent once available.
Over time the momentum of the hospitalist movement
began to gain significant ground. Many outpatient
practitioners realized that hospital medical practice was
becoming an increasingly complex endeavor: managing
a sicker inpatient load; ordering and following up on
tests; interacting with consultants and so forth. The result was that demand for the inpatient group grew and
in October 1999 the program was further expanded and
two additional physicians were added to complement
the existing three. During this year all other non-teaching services at Rhode Island Hospital (which had existed
as separate entities) were folded into the IMIS program
including the nurse practitioner service as well as the
House Officer on Private Service (HOOPs) program.
The IMIS program functioned in this capacity through
until July 2003 when further alterations were made on
account of the reduced workload for housestaff mandated by the ACGME (Accreditation Council for Graduate
Medical Education). Staffing was increased to accommodate a new chest pain observation service as well as
increased outpatient physician enrollment to the hospitalist program. In the summer of 2003 Rhode Island
Hospital’s Jane Brown 2 North Ward was designated
Sajeev Handa, M.D.,
Director, Division of Hospitalist Medicine, Rhode Island Hospital
an IMIS unit in order to streamline admissions and
discharges. In September 2003 another milestone was
achieved and the Division of Hospital Medicine was created. In 2007 plans for further expansion are underway
to increase the size of the program as well as to develop
a formal academic track for the Division’s physicians. In
2008 the IMIS unit was moved to the new Bridge Building and a second unit was added to help with geographic
localization of the inpatients. 2009 saw further changes
to the program resulting in an increase in staffing to 25
M.D.s with a plan in 2010 to increase to 30 M.D.s
The Division of Hospital Medicine is now responsible for
the following clinical programs at Rhode Island Hospital:
The Hospitalist Program – offering admissions, management through until discharge for primary care physicians who have signed up with the group;
The Community Physician Alliance Service – staffed by
primarily nurse practitioners – this program offers cross
coverage services on all medical non-teaching services during the weekdays and assistance with admissions overnight.
The Unassigned Admitting Service – responsible for
triaging appropriate unassigned and clinic patients to
the Teaching Service.
The Division of Hospital Medicine currently employs
the equivalent of twenty-seven full time University
Medicine Foundation physicians as well as four nurse
65
h o s p i ta l i s t p r o g r a m
practitioners. Physicians are expected to hold clinical
appointments with the Warren Alpert Medical School
of Brown University
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Kim A. Basu M.D.
Teaching responsibilities with the Medical School have
included the second year history and physical course as
well as preceptorship for the third year medical students.
◆◆
Member, Society of Hospital Medicine
◆◆
Member, Massachusetts Medical Society
Sajeev Handa, M.D., SFHM
FAC U LT Y M E M B ER S
Clinical Faculty
(Hospital and Foundation Based)
Instructors
Sajeev Handa, M.D., SFHM, Director
Kim A. Basu, M.D.
Vikram Behera, M.D.
Adriana Hosu, M.D.
Jaqueline Michaud, D.O.
Lina R. Nemchenok, M.D.
Joel T. Park, M.D.
Ewa Piszczek, M.D.
Fadi Samaan, M.D.
◆◆
Charter Member, Society of Hospital Medicine
◆◆
Senior Fellow in Hospital Medicine
◆◆
Member, Infectious Diseases Society of America
◆◆
Reviewer, Journal of Acquired
Immune Deficiency Syndrome
◆◆
Reviewer, Journal of Hospital Medicine
Jacqueline Michaud, D.O.
◆◆
Member, Federal Disaster Medical
Assistant Team (Homeland Security)
◆◆
Member, American College of Physicians
Lina R. Nemchenok, M.D.
◆◆
Member, Massachusetts Medical Society
◆◆
Member, Society of Hospital Medicine
Joel T. Park, M.D.
◆◆
Member, American College of Physicians
◆◆
Member, American College of Pediatricians
Ewa Piszczek, M.D.
◆◆
Member, American College of Physicians
S ELEC T ED P U B LICAT ION S
Joel T. Park. M.D.
◆◆
◆◆
66
Park, J.T. Padbury, J, Maternal Grave’s Disease and
Neonatal Hyperthyroidism Presenting as pseudo“TORCH” Syndrome in a Premature Newborn.
Park, J.T. , Hennessey. Two-week low iodine diet
is necessary for adequate outpatient preparation
for 121-I Thyrogen scanning in patients taking
levothyroxine, Thyroid 14(1): 57–63, 2004.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
HO S PI TALI S T
PROGRA M
T HE M IRIA M HO S PI TAL
OVERVIE W
T
he hospitalist program at The Miriam Hospital
(TMH) was started in August, 1997. The initial
goals were to assume the care of cardiac patients with a myriad of medical problems, and to train
Nurse Practitioners to assist cardiologists with the care
of their patients.
A significant transition occurred in 1999, as many PCPs
voluntarily relinquished their hospital admitting privileges
in order for them to concentrate on outpatient medicine.
The increasing reports about the efficient and quality
care hospitalists provide served as an impetus for the exponential growth of the program as many PCPs turned
over inpatient care of their patients to hospitalists.
The increasing role of hospitalists in medical education
resulted in another milestone for the program at TMH
in 2007 when a reorganization of schedules was made to
enable TMH hospitalists to function as ward attending
physicians for all the resident teams.
The group presently comprises 16 M.D.s and 4 Allied
Healthcare Providers (3 Nurse Practitioners and a Physician Assistant). All the Allied healthcare providers work
under the direct supervision of the Division Director
and other physicians in the group.
M I S S ION S TAT E M EN T
To provide the highest quality of Inpatient service to all
patients and utilizing prompt, and appropriate consultative and support services.
Core values: Quality, Integrity, Team Work, Compassion, and Professional Competence.
The basic tenets of the TMH hospitalist group are:
1.
2.
3.
4.
Patient care/safety
Quality of Medical care
Cost savings / revenue generation.
Academic mission (resident education and research).
The academic mission of hospitals and academic medical
centers cannot be met if operational expenses can not be
met. We therefore emphasize operational efficiency to
maintain our academic mission.
Kwame Dapaah-Afryie, M.D., Clinical Assistant Professor of Medicine
Director, Division of Hospitalist Medicine, The Miriam Hospital
T M H HO S PI TALI S T
S ERVICE S :
All the services provided are voluntary. Physicians signup for a year and this agreement is renewed automatically unless a party serves the required 3 month notice
for abrogation for the contract. A patient brochure was
designed to provide an explanation to patients about
the new Internal Medicine Inpatient Service which is
given to the patients and the PCP’s. The contract stipulates the responsibilities of the hospitalists and modes of
communication with PCPs. Ext.1.
There are 4 different services provided the TMH hospitalist group.
1.
2.
3.
4.
Teaching service
Non-teaching service
Consult service
Night Physician program
1. The teaching service is the bedrock of the academic
focus of the group. The assigned attending physicians’ call schedules match those of their resident
teams for the specified period. Attending physicians provide didactic sessions, admit and lead
their teams in the management of their patients.
Patient care as with the aviation industry has 2
major error-prone areas: Admissions (take-off) and
discharges (landing).
67
h o s p i ta l i s t p r o g r a m
The supervisory role of hospitalists assigned to
the teaching teams places great emphasis on these
error-prone areas.
Additional academic activities the group is involved
with include the preceptorship program and case
book discussions for medical students of the Warren Alpert Medical School of Brown University.
2. Non-teaching service M.D.s assigned to this service
review the orders on the overnight non-teaching
patients, round and develop daily care plans on
their assigned patients. They also admit patients
to the non-teaching service between the hours
of 7AM and 9PM. The M.D.s assigned to receive
pages regarding admissions are responsible for
making decisions regarding which patients end up
on the teaching service.
In 2009 a Geriatric fellows’ rotation in Hospital
medicine at TMH was started. The duration of
this rotation has been extended from 2 to 4 weeks
at the request of the fellows. This program serves
the dual purpose of enriching the hospitalist
non-teaching service and also provides inpatient
geriatric education for the fellows.
3. The consult service provides an opportunity for the
co-management of patients with medical urgencies
or emergencies who are on the service of subspecialists. The guidelines for this service have been
well received especially by the Orthopedists and
General and Colo-rectal surgeons.
4. The Night Attending Physicians admit all NonTeaching Medical patients between the hours of
8PM and 8AM. The hospitalists provide a courtesy
service to all the physicians with admitting privileges during these hours by admitting and caring
for their patients and providing coverage for all
in-house patient care issues.
Lifespan’s adoption of the results of a quality and patient
safety project by members of a team in the first cohort
of Lifespan/Bryant MBA students has led to a new modality for tracking CT radiation exposure in Lifelinks.
This is the second major quality initiative by TMH
hospitalists which has received wide acclamation. The
first one received the RI BCBS quality award in 2005.
The excellent teaching skills of TMH hospitalists have
been recognized by the medical residents. Drs Gentilesco
and Dapaah-Afriyie were given Department of Medicine
Teaching Attending awards in 2008 and 2009 respectively.
68
The Allied Health Providers continue to perform very
well in the midst of increasing complexity of inpatient
medicine. The Coordinator of these providers, Carol
Pearson-Riel was named TMH Employee for the month
of November in 2009.
Due to the ACGME –mandated changes in resident
work hours, the increasing acuity of hospitalized patients and new CMS initiatives, additional hospitalists
are being hired in order to maintain the academic focus
of the group without sacrificing efficiency
The general guidelines for the hospitalist group.
Ext. 1.
i. H & Ps should be dictated and signed with copies to PCPs within 48 hours of admission.
ii. COC forms should reflect correct diagnosis,
medications, pertinent test results and names of
consultants for follow-up care. These have to be
faxed to PCPs on the day of discharge.
iii.Discharge summaries should be dictated on the
day of discharge with copies to PCPs and signed
as per current medical staff by-laws.
iv. Lab data reviews: Printed laboratory data should
be reviewed at least weekly. The pertinent ones
should be given to the administrative secretaries
to be faxed to the PCPs of the patients.
v. Calls from the lab about results on patients
who already have been discharged should be
forwarded to the M.D. who discharged the patient, Medical Director or the Associate for the
appropriate follow-up calls to be made.
F a c u lt y m e mb e r s
Clinical Faculty
(Hospital and Foundation Based)
Assistant Professors
Shadaba Asad, M.D.
Papa Badoe, M.D.
Bradley Collins, M.D.
Kwame Dapaah-Afriyie, M.D., MBA
Bethany Gentilesco, M.D.
David Katz, M.D.
Deepak Thiagarajan, M.D.
a c a d e m i c y e a r s 20 08 a n d 20 09
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Shadaba Asad, M.D.
◆◆
Shadaba Asad, M.D.
◆◆
Bradley Collins, M.D.
Member, American College of Physicians
◆◆
Member, American Medical Association
Fellow of American College of Physicians
◆◆
Fellow of Society of Hospital Medicine
◆◆
Member of BetaGamma Sigma Society
Bethany Gentilesco, M.D.
◆◆
Member, American College of Physicians
◆◆
Member, Society of Hospital Medicine
◆◆
Member, American Medical Association
◆◆
Member, Infectious Disease Society of America
◆◆
Member, American Medical Association
◆◆
Member, American Medical Association
◆◆
Member, American College of Physicians
◆◆
Member, American Geriatric society
Finns JJ, Gentilesco BJ, Carver A, Lister P, Acres
CA, Payne R, Storey-Johnson C Reflective
practice and palliative care education: a clerkship
responds to the informal and hidden curricula.
Acad. Med. 2003 Mar; 78(3) 307–12. Review.
David Katz, M.D.
◆◆
Katz DE et al. Community-Phenotype Methicillin
Resistant Staphylococcus aureus Infections: Experience
in the 2005 Cubicin Outcome Registry and
Experience. Clinical Therapeutics. Nov. 2007.
◆◆
Katz DE, Heisey-Grove D, Beach M, Dicker
RC, and Matyas BT. Prolonged outbreak of
giardiasis with two modes of transmission.
Epidermiol. Infect. 2006. Mar 29:1–7.
Deepak Thiagarajan, M.D.
◆◆
Cahill, John, Dapaah-Afriyie, Kwame,
Mileno, Maria.Malaria in Rhode Island.
Observations from 1990 to 1998. Journal of
Travel Medicine. Vol8. Issue 2, 100–102.
Bethany Gentilesco, M.D.
David Katz, M.D.
◆◆
Asad S, Neill M, Opal S; Cytomegalovirus
Pneumonitis in a patient with Advanced AIDS;
Online publication Cohen and Powderly, Text
Book of Infectious Diseases; November 2004.
Kwame Dapaah-Afriyie, M.D.
Kwame Dapaah-Afriyie, M.D.
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
S ELEC T ED P U B LICAT ION S
Member, American College of Physicians.
◆◆
◆
69
infectious dise ases
DIVI S ION OF
INFEC T IO U S
DI S EA S E S
OVERVIE W
T
he mission of the Division of Infectious Diseases
is to provide state-of-the-art care for all patients
with any type of infectious disease, to teach and
mentor medical students, house officers and fellows in
the art and science of infectious diseases, and to pursue
clinical and basic research into the manifestations, treatment, and prevention of infectious diseases. Physicians
in the Division provide comprehensive inpatient and
outpatient infectious disease care to patients at The
Miriam and Rhode Island Hospitals, Memorial Hospital
and Veterans Administration Medical Center.
The Division has an in-depth focus in the area of HIV/
AIDS. The NIH-funded Lifespan/Tufts/Brown Center
for AIDS Research, based at The Miriam Hospital
under Dr. Charles C.J. Carpenter, continues to support
laboratory and clinical HIV prevention and treatment
research. The total external HIV/AIDS research funding, from all sources, for Brown University Infectious
Disease faculty per year exceeds $10,000,000. The NIH
Center grant strongly supports the primary thematic
goal of the Lifespan/Tufts/Brown CFAR, which is to
carry out translational research dealing especially with
the treatment and prevention of HIV infection in hardto-reach populations, both in New England and in several countries in the developing world. The NIH Fogarty AIDS International Training and Research Program
(AITRP) supports international clinicians and scholars
who receive further HIV related training at Brown and
affiliated hospitals. Distinctive clinical investigation has
focused on HIV in women, community-based adherence, interventions among substance users, rapid HIV
testing and microbicide and vaccine studies.
The AIDS Clinical Trials Program, under the leadership
of Dr. Karen Tashima, at The Miriam Hospital/Brown
University has been an outstanding success. This is one
of 30 units around the country, which is NIH funded
to participate in multi-center HIV and AIDS treatment
trials. Under the leadership of Dr. Susan Cu-Uvin and
Dr. Erna Milunka Kojic, the Miriam Hospital/Brown
University has played a leading role in the development
and enrollment of HIV treatment trials, specifically
for women. The Immunology Center established the
first HIV menopause clinic in the US and also provides
70
Timothy P. Flanigan, M.D., Professor of Medicine;
Director, Division of Infectious Diseases
virtually all the HIV care for pregnant women in Rhode
Island. The Center also established reproductive health
services for HIV infected serodiscordant couples in
collaboration with Women and Infants Hospital. The
HIV/Hepatitis C co-infection program directed by Dr.
Lynn Taylor has piloted innovative methods to treat coinfection among substance users.
A priority for the Division of Infectious Diseases has
been innovative models for improved prevention,
diagnosis, and treatment of HIV, particularly in the
clinical setting. Support has generously been provided
through Ryan White Titles II, III, and IV programs, as
well as Special Projects of National Significance funded
through the Ryan White Care Act. Infectious disease
physicians with a focus on HIV and AIDS provide care
not only in the hospital setting, but also at the state
prison, substance abuse treatment centers, and community health centers in the surrounding towns of Woonsocket, Fall River, and Newport. The overlap between
HIV, Hepatitis C and addiction has led to integrated
models of care and prevention. Under the leadership of
Dr. Josiah Rich, the Center for Prisoner Health and Human Rights has been established to promote diagnosis
and treatment of infectious diseases within the correctional settings nationwide. He has been recently funded
through the NIH to evaluate improved substance abuse
treatment and opiate replacement therapies in prison.
Dr. Curt Beckwith has spearheaded rapid HIV testing
a c a d e m i c y e a r s 20 08 a n d 20 09
and improved prevention in jail. A NIH funded T32
training grant supports faculty and fellows who focus
on infectious diseases among communities that suffer
disproportionately from addiction. Dr. Michelle Lally
has been funded through the Department of Defense
and the NIH to further her vaccine research and better
understand the genetics of HIV susceptibility.
The Center for Biodefense and Emerging Pathogens at
Memorial Hospital directed by Dr. Andrew Artenstein
continues its successful role both within Brown and
within Rhode Island. Dr. Artenstein, along with the
Center’s Associate Director, Dr. Marguerite Neill at
Memorial Hospital, has provided substantial community based education around biodefense since 9-11 to
a variety of medical and public safety personnel. The
Center developed educational tools for the health care
community, as well as for the broader public, and the
Center’s physicians provide 24-7 consultative services for
the RI D.O.H for bioterrorism concerns. Dr. Marguerite Neill chairs the Bioterrorism Work Group for
the Infectious Disease Society of America, which has
played a leading role in education of Infectious Disease
physicians since 9-11. As part of that effort, she has
spearheaded the development and maintenance of the
IDSA website on bioterrorism, developing authoritative
materials, including clinical pathways, for evaluation of
disease syndromes, with full text access to the references
and citations supporting the content.
The Rhode Island State Tuberculosis Treatment ​Program moved to The Miriam Hospital, Brown University School of Medicine. This has been a nationally
recognized program of excellence that was cited by the
Centers for Disease Control for its leadership nationwide in establishing directly observed therapy programs
for all persons with TB. This program has participated
in national trials to improve TB therapy. Dr. Jane
Carter has established an outstanding collaboration
with Moi University Medical School in Eldoret, Kenya,
which investigates improved TB therapeutic strategies for patients who have TB alone and for those
patients who are co-infected with HIV and TB in the
developing world, which poses unique challenges. Dr.
Awewura Kwara has received NIH funding to evaluate
the pharamacokinetics of TB treatment combined with
HIV treatment both in the US and Ghana.
Members of the Division of Infectious Diseases have had
national prominence in the field of hospital epidemiology and infection control. Dr. Leonard Mermel was
elected 25th President of the Society for Healthcare
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Epidemiology of America, a society whose members are
infection control opinion leaders from over 30 countries. He was the first author of the Infectious Diseases
Society of America (IDSA) Guidelines on Management
of Intravascular Catheter-Related Infections and he is
the Chair of the writing group revising these guidelines.
Dr. Mermel’s research team has recently investigated
innovative technologies to prevent intravascular and
bladder catheter-related infections, as well as research to
better understand the epidemiology of MRSA infections.
Dr. Mermel is the Medical Director of the Rhode Island
Hospital Department of Epidemiology & Infection Control. Dr. John Lonks, whose research focus is on resistant
pneumococcus, directs the Department of Epidemiology
and Infection Control at The Miriam Hospital.
The Division of Infectious Diseases has established a
dedicated inpatient and outpatient consultative service
to prevent and treat infections among solid organ
transplant recipients, under the direction of Dr. Staci A.
Fischer. Kidney and pancreas transplants are performed
at Rhode Island Hospital, where a multidisciplinary
team with active ID involvement also cares for recipients of other solid organ allografts performed at outside
institutions, providing clinical exposure to the care of
heart, lung and liver transplants as well. Active research
projects include investigations into the epidemiology
and risk factors for BK virus-induced nephropathy;
the pharmacokinetic impact of immunosuppressive
therapies on antiretroviral agents in the transplantation
of HIV-infected patients; and an NIH-sponsored study
in partnership with the University of Massachusetts
investigating CMV-specific T cell responses and their
impact on allograft rejection.
The Division of Infectious Diseases, in conjunction
with Pulmonary and Critical Care Medicine, has
established the Ocean State Clinical Coordinating
Center (OSCCC) at Rhode Island Hospital. Dr. Steven
P. LaRosa serves as the Director of the OSCCC and Dr.
Steven Opal, serves as Associate Director. The OSCCC
is an academic group of physicians, research nurses,
and research assistants who, working in conjunction
with a study sponsor, serve as the “real-time” main
point of contact for study sites for a variety of services.
These services include: assessment of patient eligibility
for the study, direction regarding protocol procedures,
and answering questions regarding concomitant medications and safety concerns. The OSCCC has secured
grant funding for trials of sepsis treatment interventions and severe pneumonia.
71
infectious dise ases
Dr. Kenneth Mayer has recently received multiple
awards for his outstanding work in the area of HIV prevention. He was honored by the American Foundation
for AIDS Research to receive its yearly award for leadership in the area of HIV clinical research. Dr. Mayer
has played a leading role in developing and evaluating
microbicides for the prevention of HIV, both in this
country and in resource poor settings.
Dr. Josiah D. Rich and Dr. Scott Allen have founded
the Center for Prisoner Health and Human Rights
<www.prisonerhealth.org> at the Miriam Hospital to promote research, quality health care, education and advocacy
for people detained in correctional systems. The Center
currently has over a dozen adjunctive faculty members.
Dr. Bharat Ramratnam directs the Virology Core Laboratory at Brown of the Center for AIDS Research. His
work investigates viral dynamics, and particularly HIV
viral decay. He has received funding from the Doris
Duke Foundation, NIH/ NIAID, and the Culpepper
Foundation. Recent work has focused on inhibitory activities of siRNA and the use of lactobacillus as vectors
for mucosal microbicide delivery.
Dr. E. Jane Carter, who is a national expert on TB,
oversees opportunities for clinical research for residents
in Kenya (Moi Medical School, Kenya). Drs. Mayer,
Flanigan and Cu-Uvin collaborate on HIV clinical
research in Chennai, India, Cambodia, Philippines and
Indonesia related to HIV prevention and treatment of
AIDS and opportunistic infections. Dr. Joseph I. Harwell, who was trained in both Pediatrics and Medicine,
has expertise in the area of sexually transmitted diseases
and HIV. He has developed ongoing projects in Phnom
Penh, Cambodia to evaluate the long-term morbidity
and mortality related to HIV and the potential impact
of antiretroviral therapy in Southeast Asia. He currently
provides HIV treatment guidance and training for the
Clinton Foundation. Dr. Susan Cu-Uvin has been
asked to lead the emerging program in Global Health
at Brown University. A new faculty member, Dr. Rami
Kantor, has been recruited to investigate HIV resistance
among non-clade B virus in Asia and Africa.
Dr. Susan Cu-Uvin has recently been appointed as the
Director of the Brown Initiative in Global Health. This
initiative coordinates global health activities across the
campus and hospitals.
72
f a c u lt y m e mb e r s
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Timothy P. Flanigan, M.D., Director
Charles C. J. Carpenter, M.D.
Susan Cu-Uvin, M.D.
Kenneth H. Mayer, M.D.
Leonard A. Mermel, D.O.
Steven M. Opal, M.D.
Josiah D. Rich, M.D., M.P.H.
Associate Professors
Andrew W. Artenstein, M.D.
Staci A. Fischer, M.D.
Stephen H. Gregory, Ph.D.
Joseph I. Harwell, M.D.
John R. Lonks, M.D.
Maria D. Mileno, M.D.
Marguerite A. Neill, M.D.
Bharat Ramratnam, M.D.
Karen T. Tashima, M.D.
Assistant Professors
Curt G. Beckwith, M.D.
E. Jane Carter, M.D.
Mary M. Flynn, Ph.D., R.D., L.D.N.
Fizza S. Gillani, Ph.D.
Rami Kantor, M.D.
Erna Milunka Kojic, M.D.
Awewura Kwara, M.D.
Michelle A. Lally, M.D.
Steven P. Larosa, M.D.
Jennifer A. Mitty, M.D.
Michael C. Newstein, M.D., Ph.D.
Amy Nunn, Sc.D.
Aurora Pop-Vicas, M.D.
Lynn E. Taylor, M.D.
Instructors
Nickolas D. Zaller, Ph.D.
Clinical Faculty
(Hospital and Foundation Based)
Associate Professors
Dennis Mikolich, M.D.
Assistant Professors
Tanya Ali, M.D.
Patricia A. Cristofaro, M.D.
Melissa M. Gaitanis, M.D.
Jerome M. Larkin, M.D.
Michael T. Poshkus, M.D.
a c a d e m i c y e a r s 20 08 a n d 20 09
Volunteer Clinical Faculty
Associate Professors
Scott A. Allen, M.D.
Glenn Fort, M.D.
Assistant Professors
Jeffrey Bratberg, Pharm.D.
Instructors
Rinchen-Tzo Emgushov, M.D.
Husam Issa, M.D.
Eleni Patrozou, M.D.
◆◆
Invited Pr esentations
◆◆
◆◆
“U.S. Health Professionals and Torture.”
Presentation at the Institute of Medicine
Annual meeting, October, 2009.
◆◆
“More on Detainee Deaths.” Presentation at
Harvard Law School, Human Rights Program
Workshop on Medical Examiners and Forensic
Investigations: Are international, legal and
ethical norms sufficient? May, 2009.
◆◆
◆◆
◆◆
◆◆
“Interrogations, Forced Feedings and the Role of Health
Professionals.” Book launch, Human Rights Program
at Harvard Law School, Cambridge, May 2009.
“Advocating for Prison Health Care: Healthier
Prisons for Healthier, Safer Communities.”
Boston Bar Association and Massachusetts
Correctional Legal Services, John Adams
Courthouse, Boston, March 2009.
“Management of Hunger Strikes.” Workshop planning
member and presenter at the Institute of Medicine
Workshop on Military Medical Ethics: Issues
Regarding Dual Loyalties. Sponsored by the Office
of the Assistant Secretary of Defense for Health
Affairs and the Greenwall Foundation, National
Academy of Sciences, Washington, DC, Sept, 2008.
“Medical Evidence of Torture by US Personnel.”
Briefing before the US Helsinki Commission, US
Commission on Security and Cooperation in
Europe, US Congress, Washington, DC, July, 2008.
Medical Advisor, Physicians for
Human Rights, 2005–present.
Honors And Awards
◆◆
Editorial Advisory Board, Journal of Infectious Diseases.
◆◆
Reviewer for Textbook: Textbooks of Military Medicine:
Medical Aspects of Biological Warfare. In: Dembek ZF,
ed. Office of The Surgeon General, Department of the
Army: Falls Church, VA and Borden Institute Walter
Reed Army Medical Center: Washington DC, 2007.
Schol arly Activities
◆◆
Scientific Steering Committee, New England
Regional Center of Excellence in Biodefense
and Emerging Infectious Diseases (NERCE),
Harvard Medical School, granted by the National
Institute of Health, Boston, MA, 2003–present.
◆◆
Chairman, Data Safety Monitoring Board, Juvaris
BioTherapeutics Inc, H-100-001 – “Randomized,
double blind, controlled Phase 1 trial of the
safety, tolerability and immunogenicity of
JVRS-100 adjuvant at ascending dose levels
administered with Fluzone® inactivated trivalent
influenza virus vaccine”, Pleasanton, CA, 2007
◆◆
Special Emphasis Panel, National Institute of
Allergy & Infectious Diseases, National Institutes
of Health, RFA-08-001 – “Cooperative Research
Partnerships for Biodefense and Emerging
Infectious Diseases (U01)”, Bethesda, M.D., 2008
◆◆
Artenstein AW, ed. Vaccines: A biography.
Springer Publishing 2009.
Invited Pr esentations
◆◆
“The Case of Fathi El-Jahmi.” Annual meeting of the
National Academies of Engineering and presentation
before the Committee on Human Rights of the
National Academies, Washington, DC, 2008.
Andrew W. Artenstein, M.D.
Community Acquired Pneumonia - Department
of Microbiology and Pediatrics, BSM Medical
University, Dhaka, Bangladesh, November 2006.
Scott A. Allen, M.D.
j u ly 1 , 20 07 – j u n e 30 , 20 09
Schol arly Activities
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Tanya Ali, M.D.
◆
Curt G. Beckwith, M.D.
Honors And Awards
◆◆
Centers for Disease Control and Prevention, National
Center for HIV/AIDS, Viral Hepatitis, STD, and TB
Prevention. Partners in Public Health Improvement
External Group Award, HIV Testing Implementation
Guidance for Correctional Settings Group,
Division of HIV/AIDS Prevention, April, 2009.
Invited Pr esentations
◆◆
The experience of initiating routine screening for HIV
in jail settings. The Ryan White HIV/AIDS Program
Grantee meeting, Washington, DC; August 26, 2008.
73
infectious dise ases
◆◆
The Expansion of HIV Testing in Jails; as part of
Implementation of Routine Testing: Traditional and
Non-Traditional Clinical Settings, 2008 National
Summit on HIV Diagnosis, Prevention, and Access
to Care; Arlington, Virginia, November 20, 2008.
Schol arly Activities
◆◆
◆◆
Review Committee member, National
Institute on Drug Abuse, RFA DA08-021
Screening, Brief Intervention and Referral
to Treatment (SBIRT) for Drug Abuse in
General Medical Settings (RO1); July, 2008.
Review Committee member, Special Emphasis
Panel of the Centers for Diseases Control and
Prevention, National Center for HIV, STD,
and TB Prevention; RFA PS09-004 Screening
Targeted Populations to Interrupt On-going
Chains of Transmission with Enhanced Partner
notification-The STOP Study; and RFA PS09005 Demonstration Project of Elective Adult Male
Circumcision Conducted in Sexually Transmitted
Diseases Clinics in the United States; April, 2009.
Jeffrey Bratberg, Pharm.D.
◆◆
Charles C.J. Carpenter, M.D.
Honors And Awards
◆◆
ACCP New Educator Award (National), April 2009.
Invited Pr esentations
◆◆
◆◆
◆◆
Invited lecturer, “What should we prepare for?
Identifying Risks and Surge Requirements” and
panel discussant and Meeting Program Associate
for “Emergency Planning for Logistical and
Operational Surge Capacity.” American Society
of Health System Pharmacists (ASHP) Mid-Year
Clinical Meeting, Las Vegas, NV, Dec. 2007.
Doyle T, Brescia S, Fong M, Thibault K, Bratberg
J. “Pharmacists’ role in emergency preparedness
administration procedures for pandemic influenza
in a hospital setting.” Student Section, American
Society of Health System Pharmacists (ASHP) MidYear Clinical Meeting, Las Vegas NV, Dec. 2007.
Johnson C, Tysiak M, Konecny M, Wilcox
N, Bratberg J. “The Pandemic Is Coming:
Pharmacists’ roles in triage, infection control, and
admissions.” Student Section, American Society
of Health System Pharmacists (ASHP) Mid-Year
Clinical Meeting, Las Vegas NV, Dec. 2007.
Schol arly Activities
74
◆◆
Pharmacy Leadership Society (PLS), Feb 2008–present.
◆◆
American Association of Colleges of
Pharmacy July 2004–present.
◆◆
American Pharmacists Association,
March 2004–present.
Robert H. Williams, M.D., Distinguished
Chair of Medicine Award, Association
of Professors of Medicine, 2007.
Invited Pr esentations
◆◆
James Marsh Professor-at-Large, University
of Vermont, 2007–2008.
Schol arly Activities
◆◆
Member, US Delegation, US-Japan Cooperative
Medical Science Program, 2008–2009
◆◆
Member Expert Panel, US-India Joint Working
Group on HIV/AIDS Prevention, 2008–2009
◆◆
Senior Scientific Advisor, Expert Advisory
Committee, Indo-US Cooperative
Program on HIV/AIDS, 2008–2009
◆◆
Member, DHHS, NIH, Office of AIDS
Research, Microbicides Research Working
Group (MRWG), 2008–2009
◆◆
Member NIH, NIAID, DAIDS, HIV/
AIDS Clinical Trials Networks, Strategic
Working Group (SWG), 2008–2009.
◆◆
Chairman, Treatment Subcommittee, Committee
for the Evaluation of the President’s Emergency
Fund for AIDS Relief (PEPFAR), 2005–2008
Honors And Awards
◆◆
Consultant, Clinton Foundation Mentor to
Commonwealth of the Bahamas, Ministry
of Health and Social Development – Center
for HIV/AIDS May 2008–present.
E. Jane Carter, M.D.
Honors And Awards
◆◆
President Elect, North American Region, International
Union Against TB and Lung Disease, 2009.
Schol arly Activities
◆◆
Liaison Member, Advisory Committee for the
Elimination of Tuberculosis, CDC, 2006–2007.
◆◆
Board Member, World Lung
Foundation, 2005–present.
◆◆
Advisory Committee Member (Tuberculosis) Millennium Village Project, 2006–present.
◆◆
Technical Consultant in TB and TB/HIV, USAID,
PEPFAR, AMPATH, Eldoret, Kenya, 2006–2007.
◆◆
Reviewer: American Journal of Respiratory
and Critical Care Medicine, PLOS, The
International Journal of Tuberculosis
and Lung Disease, 2007–present.
a c a d e m i c y e a r s 20 08 a n d 20 09
Susan Cu-Uvin, M.D.
Honors And Awards
◆◆
Member, The Women’s Health Internetwork Scientific
Committee, AIDS Clinical Trials Group, 2007.
◆◆
Editorial Board, Infectious Diseases in
Obstetrics and Gynecology, 2008.
◆◆
Member, Institute of Medicine, National
Academy of Sciences, Committee on
Women’s Health Research, 2008.
Schol arly Activities
◆◆
Member, Infectious Disease Society of
Obstetrics and Gynecology Scientific
Program Committee, 2007–2009.
◆◆
Chair, NIH Advisory Committee: HIV-Related
Research in Women and Girls, 2008.
◆◆
Chair, Special Emphasis Panel Review, ZRG1
AARR-J 40P, Population and Behavioral
Studies in HIV/AIDS, 2009.
◆◆
Review Panel, Special Emphasis Panel
Review, ZRG1 BBBP-J (58) and ZRG1
BBBP-L (58) in HIV/AIDS, 2009.
◆◆
◆◆
Finalist, Charles C. Shepard Science Award, the
Centers for Disease Control and the Agency for
Toxic Substances and Disease Registry, presented to
the authors of the most outstanding peer-reviewed
research paper published by CDC/ATSDR, 2007.
◆◆
Named to “Best Doctors in America”, 2007–2008
◆◆
Triple Your Heart “Kindness Matters
Award,” in recognition of outstanding acts of
kindness, generosity and leadership, 2007.
Invited Pr esentations
◆◆
Moderator, American Transplant Congress, San
Francisco, Infections: HIV and Miscellaneous
Viral Infections, May 5–9, 2007.
◆◆
Moderator, Donor-derived Infections
and HIV, American Transplant Congress,
Boston, Massachusetts, June 2009.
Schol arly Activities
◆◆
Co-Chair, Donor Infections Committee, American
Society of Transplant Infectious Diseases
Community of Practice, August 2008 to present.
Timothy P. Flanigan, M.D.
Honors And Awards
◆◆
◆◆
Castle Connolly Medical Ltd, America’s
Top Doctor, 2007–2008.
CDC/ATSDR Honor Award Partners
in Public Health, 2009.
j u ly 1 , 20 07 – j u n e 30 , 20 09
CDC National Center for HIV/AIDS, Viral
Hepatitis, STD and TB Prevention Award, 2009.
Invited Pr esentations
◆◆
Meet the Professor Session: “HIV in
Correctional Facilities.” 45th IDSA Annual
Meeting, San Diego, CA. October 4–7, 2007.
◆◆
“Incarcerated Populations – Prevention
and Community Linkages.” 2007
National HIV Prevention Conference,
Atlanta, GA. December 2–5, 2007.
◆◆
“HIV and Infectious Disease Care in Jails and
Prisons: Scaling the Walls with the help of
Academic Medicine.” Presented at the 2008 Annual
American Clinical and Climatological Association
Meeting, Ponte Vedre, FL, October 17, 2008.
◆◆
“D.O.C Testing and Linkage to Care.” Presented
at the Gilead Medical Affairs Advisory Program
on HIV, Washington, DC, June 12, 2009.
Schol arly Activities
◆◆
Member, American Federation for
Clinical Research, 2007–present.
◆◆
Member, International AIDS
Society-USA, 2007–present.
◆◆
Member, American Clinical and
Climatological Society, 2007–present.
Staci A. Fischer, M.D.
Honors And Awards
◆
Glenn Fort, M.D.
Invited Pr esentations
◆◆
Fishman M, Fort GG, Mikolich DM. Effective
Recognition of Clean Equipment.Abstract of
the 35th Annual Educational Conference &
International Meeting of the Association for
Professionals in Infection Control and Epidemiology
(APIC) Denver, Colorado, June 2008.
◆◆
Fishman M, Fort GG, Mikolich DM. Creative
Methods to Improve Performance. Abstract
of the 35th Annual Educational Conference &
International Meeting of the Association for
Professionals in Infection Control and Epidemiology
(APIC) Denver, Colorado, June 2008.
Schol arly Activities
◆◆
Relevance reviewer for the Subspecialty Board
in Infectious Diseases of the American Board
of Internal Medicine 2001–Present.
Melissa M. Gaitanis, M.D.
Schol arly Activities
◆◆
Member, American Medical Association
◆◆
Member, Infectious Diseases Society of America
◆◆
Member, HIVMA
75
infectious dise ases
Fizza S. Gillani, Ph.D.
◆◆
Honors And Awards
◆◆
Doctoral Thesis External Examiner to evaluate
Ph.D. dissertations completed by the Ph.D.
students of Pakistan Institute of Development
Economics, Islamabad, Pakistan. 2007–present
Schol arly Activities
◆◆
Reviewer, Health Services and Outcomes Research
Methodology, an International Journal Devoted to
Quantitative Methods for the Study of the Utilization,
Quality, Cost and Outcomes of Health Care, 2008.
Stephen H. Gregory, Ph.D.
Invited Pr esentations
◆◆
Kupffer cells regulate inflammation and host
defenses to systemic bacterial infections. Division
of GI/Liver Diseases, Mouth Sinai School of
Medicine, New York, NY Jan. 29, 2008.
Schol arly Activities
◆◆
Panel Member, NIH Vaccine study
Section ZRG1 IMM-G 12B
◆◆
Panel Member, NIH Special Emphasis
Panel ZRG1 Imm F02 M
◆◆
NIAID Special Study Section – Unsolicited
PO1 application “Tularemia Immunology”
◆◆
Ad Hoc Reviewer – Journal of Immunology,
Cellular Immunology, Infection and Immunity,
Journal of Leukocyte Biology, Immunity, Journal
of Infectious Diseases and Hepatology
Schol arly Activities
◆◆
Member – Scientific Advisory Board,
China National Center for AIDS.
◆◆
Member - Faculty Executive Committee,
Brown/Tufts Fogarty AIDS International
Training and Research Program.
Hussam Issa, M.D.
Schol arly Activities
◆◆
Member, American Medical
Association, 2006–present.
◆◆
Member, Infectious Disease Society of
North America, 2003–present.
◆◆
American College of Physicians 1999–present.
Rami Kantor, M.D.
Invited Pr esentations
◆◆
Principles in HIV drug resistance and
interpretation. Kenya Medical Research
Institute; April 16, 2008, Nairobi, Kenya.
◆◆
Session Chair and Presenter: Epidemiology and
principles of HIV drug resistance. Chennai HIV
antiretroviral treatment symposium (CART
2009); January 9–10, 2009; Chennai, India.
◆◆
Faculty and Presenter: TREAT Asia Resistance
Data Management and Biostatistics Training
Workshop; June 22–25, 2009, Bangkok, Thailand.
Joseph I. Harwell, M.D.
Honors And Awards
◆◆
Elected to Fellowship, Infectious
Diseases Society of America, 2007.
Invited Pr esentations
◆◆
◆◆
76
“Evaluation and management of patients
receiving antiretroviral therapy.” Second line
antiretroviral therapy technical training symposium,
Zhengzhou, China, December 12–14, 2007.
“HIV and Hepatitis Co-Infection.” Annual
Continuing Medical Education Symposium.
Sihanouk Hospital Center of HOPE, Phnom
Penh, Cambodia, October 6–10, 2008.
◆◆
National Pediatric HIV Workshop, Lae,
Papua New Guinea, March 16–20, 2009.
◆◆
Semi-annual pediatric HIV care providers’
network meeting, National Pediatric Hospital,
Phnom Penh, Cambodia, March 23–27, 2009.
“Plasma (PVL) and genital tract (GTVL) viral load
changes in Cambodian women during 18 months of
ART” at International Congress on AIDS in ASIA
and the Pacific, Bali, Indonesia, August 12, 2009.
Schol arly Activities
◆◆
Grant reviewer, The National Medical
Research Council (Singapore)
◆◆
Academic Promotion Reviewer, Dr. Visva Pillay,
the National Research Foundation, South Africa
◆◆
Academic Promotion Reviewer, Dr. David
Hassin, Tel Aviv University, Tel Aviv, Israel
◆◆
Director of Research, Brown University/Kenya Program
Erna Milunka Kojic, M.D.
Invited Pr esentations
◆◆
A Phase II Study to Evaluate the Immunogenicity
and Safety of a Quadrivalent Human Papillomavirus
Vaccine in HIV Infected Females. Presented
at the OpMAN Plenary Session, ACTG
Meeting, Washington, DC. October 16, 2007.
◆◆
HIV and Menopause. Presented at Oak Tree
Clinic, British Columbia Women’s Hospital,
Vancouver, British Columbia. December 3, 2007.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
◆◆
◆◆
Women with HIV infection. Presented at Oak
Tree Clinic, British Columbia Women’s Hospital,
Vancouver, British Columbia. December 3, 2007.
Menopause. Presented at the 5th Annual Women
and HIV International Clinical Conference
(WHICC), Dallas, Texas. April 29, 2008.
HP and HIV. Presented at the 5th Annual Women
and HIV International Clinical Conference
(WHICC), Dallas, Texas. April 29, 2008.
Protocol Chair: ACTG 5240 A Phase II Study
to Evaluate the Immunogenicity and Safety
of a Quadrivalent Human Papilloma Virus
in HIV Infected Females, 2007–present.
◆◆
Co-Chair SUN Committee, 2007–present.
◆◆
Manuscript Reviewer, American Journal of
Tropical Medicine & Hygiene, 2007–present
◆◆
Manuscript Reviewer, International Journal
of Infectious Diseases, 2007–present.
Awewura Kwara, M.D.
◆◆
Physician Leadership Academy, “Evaluating
Individual Leadership Skills”, Rhode Island
Hospital through The Advisory Board
Company, Washington, DC, 2008
◆◆
Member, Adolescent Medicine Leadership Group
of the Adolescent Trials Network (ATN), 2008.
◆◆
Grant Peer Reviewer, Special Emphasis Panel,
Centers for Disease Control and Prevention
(CDC), Grants for Public Health Research, 2009.
Steven P. Larosa, M.D.
Invited Pr esentation
◆◆
Reviewer for Canadian Institutes of Health
Research, Canada, 2007–present.
◆◆
Peer Reviewer for Center for Scientific Review
(NIH) - Special Emphasis Panel for AITRP
and ICOHRTA AIDS/TB programs, 2008.
Michelle A. Lally, M.D.
Invited Pr esentations
◆◆
Participant, “Novel Technologies in Rapid HIV
NAT Assay Diseases”, Rapid HIV-1 Viral Detection
Workshop, Bethesda, M.D., July 12–13, 2007.
◆◆
Speaker, “Early Stopping of Phase IIB Proof
of Concept Trial of Merck AD5 Vaccine”,
IMPAACT Vaccine/Immunobased Therapy
Scientific Committee Meeting, Hyatt Hotel,
Washington, DC, October 10–12, 2007.
“Purpura Fulminans.” Grand Rounds: Cleveland
Clinic Foundation, Division of Infectious Diseases/
Vascular Medicine, Cleveland, OH, April 11, 2007.
John R. Lonks, M.D.
Schol arly Activities
◆◆
Schol arly Activities
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Schol arly Activities
Schol arly Activities
◆◆
◆
3M Healthcare grant: Quantitation of
methicillin-resistant Staphylococcus aureus
(MRSA) colony forming units (Cfu’s) in
subjects testing positive for MRSA, 2007.
Kenneth H. Mayer, M.D.
Honors And Awards
◆◆
Fellow, Infectious Diseases Society of America, 2007.
◆◆
HIV Medicine Association Citation, 2007.
Invited Pr esentations
◆◆
Keynote Presentation, “Antiretrovirals for Prevention:
Panacea or Pandora’s Box?” HIV Prevention in
the Care Setting: Implications for Management
of Sexually Transmitted Infections, 45th Annual
Meeting of the Infectious Diseases Society of
America, San Diego, CA, Oct. 4–7, 2007.
◆◆
Keynote Speaker, “The Third Decade of AIDS:
Progress and Challenges,” World AIDS Day, McGill
University, Montreal, Canada, November 28, 2008.
◆◆
Speaker, “Early Stopping of the STEP Trial”,
ATN Network Meeting, Hilton Hotel, Silver
Spring, M.D., October 16–19, 2007.
◆◆
Session Chair, HIV-The Basics, 2009
ACTHIV National HIV Providers Conference,
Denver, CO, May 15–17, 2009.
◆◆
Presenter and Participant, “The Context of
Biomedical HIV Prevention for Youth”, NIH
Consultation on the Inclusion of Adolescents in HIV
Biomedical Prevention Clinical Trials, Forum for
Collaborative HIV Research, The George Washington
University, Washington, DC, June 18–19, 2009.
◆◆
Symposium presenter, “Identification of HIV
Risk as a Potential Indicator of ARV Therapy:
Design and Potential Implications of HPTN
061/” Integration of Prevention and Therapeutic
HIV Research: Opportunities and Challenges,
AIDS Clinical Training Grant Network Meeting,
Washington, DC, June 24–28, 2009
77
infectious dise ases
Schol arly Activities
◆◆
Co-Chair “Findings from Phase III Trials”
Abstract Session, Microbicides 2008, New
Delhi, India, February 24–27, 2008.
◆◆
Symposium Co-Chair, “Antiretrovirals for
Prevention of HIV”, 13th International Congress
on Infectious Diseases, Kuala Lumpur, June, 2008.
◆◆
External Peer Reviewer, HIV/AIDS program, Division
of HIV/AIDS Prevention, CDC, April 13–15, 2009.
◆◆
Steering Committee, 2nd national Conference
on HIV/AIDS Therapy: Current Practices &
Future Options. Mumbai, India, January 2009.
Schol arly Activities
◆◆
Amy Nunn, Sc.D.
Invited Pr esentations
◆◆
Guest Lecturer, The Politics, History and Cost of
AIDS Treatment in Brazil. University of Toronto
Leslie Dan Faculty of Pharmacy, September 19, 2008.
◆◆
Guest Lecturer, Scaling Up AIDS Treatment
in Resource-Limited Settings: Lessons from
Brazil. University of Pennsylvania Center
for Center for Mental Health Policy and
Services Research, November 17, 2008.
◆◆
Panelist Implementation of Routine HIV Testing:
Traditional and Non-Traditional Clinical Settings.
Presented lessons from Philadelphia Public STD
Clinics. National Summit on HIV Diagnosis,
Prevention, and Access to Care. HIV Implementers
Conference, Arlington VA, November 20, 2008.
◆◆
Guest Lecturer, Global Health, Global
Governance and HIV/AIDS. Dartmouth
College, May 21–22, 2009.
Leonard A. Mermel, D.O.
Invited Pr esentations
◆◆
Invited Speaker, The Changing Natural History of
Infections: New Challenges for Antibiotic Treatment
and Prevention. Italian Society of Infectious and
Tropical Diseases, Milan, Italy. State of the Art
Lecture: Nosocomial Infections, March, 2007.
◆◆
Keynote Speaker, Dutch Hospital Safety Program,
Utrecht, Netherlands. Prevention of Catheter
Related Bloodstream Infection, May, 2009.
◆◆
Course Co-Director Society for Healthcare
Epidemiology of America/Infectious Diseases
Society of America, Annual Infection Control
Fellow’s Course, Baltimore, M.D., 2009.
Schol arly Activities
◆◆
◆◆
Schol arly Activities
◆◆
Reviewer for Public Library of Science
Medicine, 2008–present.
◆◆
Editorial Advisory Board, Infection Control
and Hospital Epidemiology, 2004–2010.
Reviewer for Public Library of
Science ONE, 2008–present.
◆◆
Reviewer for AIDS Care, 2007–present.
Editorial Board, Infection, 2007–present.
◆◆
Reviewer for Journal of Epidemiology and
Community Health, 2008–present.
Maria D. Mileno, M.D.
Honors And Awards
◆◆
Appointed Global Health Advisor for Americare
Corporation, June 2007–present.
Jennifer A. Mitty, M.D.
Steven M. Opal, M.D.
Honors And Awards
◆◆
Public Library of Science PLOS One
Academic Editor, 2008–present.
◆◆
Guest editor: Critical Care Supplements. Severe
Community-acquired pneumonia, 2008–2009.
◆◆
Research Editor- Critical Care Current Science
LTD, Senior Editor: J-L Vincent – 2008.
Invited Pr esentation
◆◆
Community Based Modified Directly
Observed Therapy. Presented at NIMH/
IAPAC International Conference on HIV
Treatment Adherence, Jersey City, NJ, 2007.
Invited pr esentation
◆◆
Michael C. Newstein, M.D., Ph.D.
Invited Pr esentation
◆◆
78
Development of novel combinatorial genetic
selection strategy for cellular microRNAs
which modulate HIV infection
“HIV Update 2009” at Milford Regional
Medical Center, Universality of Massachusetts
Medical School Milford MA
The World Congress of Nephrology, “The
pathophysiology of sepsis: experimental data to
new therapies, Milan, Italy, May 24, 2009.
Schol arly Activities
◆◆
NIAID Cooperative Research for Biodefense
and Emerging Infectious Diseases – 2008.
◆◆
Chairperson, A phase II/III clinical study
of TAK-242 as a treatment strategy in
severe sepsis Takeda, 2005–2008.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
◆◆
◆◆
◆◆
The Nathaniel Adamczyk Foundation
Research Program, Reviewer for the Nathaniel
Adamczyk Foundation Research for prevention
of Pediatric ARDS grants, 2008–2009.
The utility of anti-core LPS vaccine in the prevention
and treatment of F. tularensis in a murine model
of pulmonary tularemia. NIH New Opportunities
grant from the New England Regional Center
of Excellence in Biodefense. Co PI- S. Opal, AS
Cross, Kessimian N, and S. Gregory (100,000
dollars/yr) June 1, 2006–May 31, 2008
The use of microarray and molecular beacon and
microfluidics technology in the rapid detection of
influenza genomic RNA. K21 award Co-investigator.
A. Tripathi PI (50,000 dollars/yr) Sept 2009–Jan. 2011.
The Ocean State Clinical Coordinating Center
Grant for international trials in Critical Illness. Co
director – M. Levy and S. LaRosa (110,000/yr) (direct
costs 4.1 million dollars) Jan 2006–June 2011.
Invited Pr esentations
◆◆
◆◆
Member, Infectious Diseases Society
of America, 2006–present.
◆◆
NIH ADDT study section, 2007.
◆◆
Lifespan/Brown/Tufts CFAR pilot
project applications, 2007.
◆◆
Gene therapy programs, The
Netherlands, 2007–present.
◆◆
Health Research Board, Ireland, 2007.
Josiah D. Rich, M.D.
Honors And Awards
◆◆
HPV, Infectious Diseases Conference,
Athens, Greece, March, 2009.
◆◆
Clostridium difficile, Infectious Diseases
Conference, Athens, Greece, March, 2009.
Schol arly Activities
◆◆
Principal Investigator, European funded
program “PROMOVAX: promote vaccinations
among migrant populations in Europe”October
2009-October 2012, 10 different EU countries,
WHO and Brown are collaborating in this project.
Aurora Pop-Vicas, M.D.
◆◆
Invited Presenter: “The Importance of HIV Treatment
and Care for Inmates and Continuity of Care PostRelease”, AmFAR Congressional Briefing, “HIV in
Correctional Settings: Implications for Prevention and
Treatment Policy”, Washington, DC, April 22, 2008.
◆◆
Invited Participant: “Implementing Routine HIV
Testing in Correctional Facilities: Challenges
and Opportunities”, Forum for Collaborative
HIV Research, The George Washington
University, Washington, DC, April 27, 2009.
◆◆
Invited Speaker: “HIV in Corrections”,
American Society of Addiction Medicine
Annual Medical-Scientific Conference, New
Orleans, LA, April 30–May 3, 2009.
◆◆
Invited Participant: “Physicians for Human
Rights Leadership Summit: AIDS and the Right
to Health,” Washington, DC, June 8–9, 2009.
Schol arly Activities
◆◆
National Institutes of Health, AIDS Fellowship
Reviewer, Center for Scientific Review, 2007
◆◆
Scholarship Reviewer, National HIV
Prevention Conference, 2007.
Schol arly Activities
◆◆
◆◆
Rhode Island Medical Foundation Grant # 20080311
Role: principal investigator Project: The clinical and
molecular epidemiology of Clostridium difficile in a
long-term care facility. Period of funding: 2/15/08–
2/15/09. Support for period of funding: $10,000.
Department of Medicine Research Development
Award – Brown University. Role: principal
investigator. Project: The impact of influenza
vaccination on ADL decline in the nursing-home
elderly. Period of funding: 5/15/09–5/15/11. Support
for period of funding: $35,000 per academic year.
Delegate, Massachusetts Medical Society (MMS),
House of Delegates (HOD), 2009–2010.
Invited Pr esentations
Invited Pr esentations
◆◆
February 2008 Anti-HIV Gene Silencing,
Microbicides 2008, New Delhi, India, 2008.
Schol arly Activities
Honors And Awards
Member, European Society of Clinical Microbiology
and Infectious Diseases, 2008–present.
j u ly 1 , 20 07 – j u n e 30 , 20 09
Bharat Ramratnam, M.D.
Eleni Patrozou, M.D.
◆◆
◆
◆◆
NIH Peer Reviewer, AIDS Fellowship Meeting, 2008.
◆◆
Editorial Board Member, Virulence Journal, 2009.
◆◆
NIDA (X02) Application Reviewer, NIDA
Director’s Avant-Garde Award, 2009.
Karen T. Tashima, M.D.
Invited Pr esentations
◆◆
“HIV Treatment Update” 4th Annual HIV
Update, Provincetown, MA, April 27, 2008.
◆◆
“HIV Update” 2008 CME Lecture at Saint Anne’s
Hospital, Fall River, MA May 21, 2008.
79
infectious dise ases
◆◆
“Positive Paths: A Motivational Intervention
for Smoking Cessation Among HIV Smokers”
Oral Presentation Conference on Retroviruses
and Opportunistic Infections (CROI),
Montreal, Canada February 8–11, 2009.
Schol arly Activities
◆◆
Reviewer for the Brown University/Women &
Infants Hospital National Center of Excellence in
Women’s Health (CoE) Innovations in Women’s
Health Research Seed Grant Program, 2007.
S ELEC T ED P U B LICAT ION S
Scott Allen, M.D.
◆◆
Allen S. Physicians, mass incarceration, and medical
ethics. J Clinical Ethics 2008; 19(3): 260–7.
◆◆
Chew K, Allen S, Taylor L, Rich J, Feller E.
Treatment outcomes with pegylated interferon and
ribavirin for male prisoners with chronic hepatitis
C. J Clin Gastroenterol 2009; 43(7):686–91.
◆◆
Zaller N, Taylor L, Allen S, Rich J. Hepatitis
C in correctional institutions. Current
Hepatitis Reports 2007; 6:114–8.
Lynn E. Taylor, M.D.
Invited Pr esentations
◆◆
Taylor L, Gholam P, Delong A, Rompalo A, Klein
R, Schuman P, Gardner L, Carpenter C, HIV
Epidemiology Research (HER) Study Group.
Occult hepatitis B virus (HBV) and hepatitis
C virus (HCV) viremia in women with and atrisk for HIV/AIDS. (Oral Presentation, Session
THAB0204) AIDS 2008: XVII International AIDS
Conference, Mexico City, Mexico, August 3–8, 2008.
◆◆
Skills Building Workshop, “Global HIV/HCV
Co-infection: Barriers to HCV Treatment and
Models of Integrated HIV/HCV Care.” AIDS
2008: XVII International AIDS Conference,
Mexico City, Mexico, August 4, 2008.
◆◆
Taylor LE, DeLong AK, Gholam PM, Mayer KH,
Rodriguez Perez I, Shah R, Chapman S, Ducharme
RB, Wohlschlegel W, Chapin KC, Rich JD. Screening
for Acute Hepatitis C Virus Infection among At-Risk
Patients in an HIV Clinic. (Oral Presentation 173)
13th International Symposium on Viral Hepatitis and
Liver Disease, Washington, DC, March 20–24, 2009.
Andrew W. Artenstein, M.D.
◆◆
Artenstein AW. New generation smallpox
vaccines: A review of preclinical and clinical
data. Rev Med Virol 2008; 18(4):217–31.
◆◆
Artenstein AW, Grabenstein JD. Smallpox
vaccines for biodefense: Need and feasibility.
Expert Rev Vaccines 2008; 7(8):1225–37.
Curt G. Beckwith, M.D.
◆◆
Beckwith CG, Cornwall AH, Dubrow R, Chapin
K, Ducharme R, Rodriguez I, Velasquez L,
Merson MH, Sikkema KJ, Mayer K. Identifying
acute HIV infection in Rhode Island. Medicine
& Health Rhode Island 2009; 92: 231–3.
◆◆
Blood E, Beckwith C, Bazerman L, Cu-Uvin S,
Mitty J. Pregnancy among HIV-infected refugees
in Rhode Island. AIDS Care 2009; 21: 207–11.
Jeffrey Bratberg, PharM.D.
◆◆
Feret B, Bratberg J. A pharmacist-based intervention
to prepare the elderly population for emergencies.
J Amer Pharmacists Association 2008; 48:780–3.
◆◆
Matson K, Bratberg J. “Aerugen®: A vaccine for the
prevention of Pseudomonas aeruginosa infection in
cystic fibrosis patients.” Drug Dev Res 2007; 68:512–21.
Schol arly Activities
80
◆◆
Manuscript Reviewer, Clinical
Infectious Diseases, 2008.
◆◆
Manuscript Reviewer, Journal of
Infectious Diseases, 2007.
◆◆
Manuscript Reviewer, Gastroenterology, 2008.
◆◆
Manuscript Reviewer, Center for Substance
Abuse Treatment (CSAT) Knowledge Application
Program, Treatment Improvement Protocol
(TIP): Addressing Viral Hepatitis in People
with Substance Use Disorders, 2009.
◆◆
Electronic Grant Reviewer, National Institute
on Drug Abuse “Cutting Edge Basic Research
Award Program” (CEBRA), 2007.
Charles C.J. Carpenter, M.D.
◆◆
Gillani FS, Zaller ND, Zeller K, Rich JD, CuUvin S, Flanigan TP, Carpenter CCJ. Changes in
demographics and risk factors among persons living
with HIV in an academic medical center from
2003–2007. Med & Health RI 2009; 92(7):237–40.
E. Jane Carter, M.D.
◆◆
Waxman M, Kimaiyo S, Ongaro N, WoolsKaloustian K, Flanigan T, Carter EJ. Initial
outcomes in an emergency department HIV
testing program in Western Kenya. AIDS
Patient Care and STDs 2007; 21(12):981–6
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
Kwara A, Herold JS, Machan JT, Carter EJ. Factors
associated with failure to complete isoniazid
treatment for latent tuberculosis infection
in Rhode Island. Chest 2008; 133:862–8.
◆◆
Braitstein P, Nyandiko W, Vreeman R, WoolsKaloustian, Sidle J, Musick B, Ayaya S,
Yiounnoutsis C, Carter EJ. The incidence of
tuberculosis among HIV-infected children in
a large observational cohort in Western Kenya.
Pediatric Infect Dis J 2009; 28(7):626–32.
◆◆
◆◆
◆◆
Anderson B, Wang CC, DeLong A, Liu
T, Kojic E, Kurpewski J, Ingersoll J, Mayer
K, Caliendo A, Cu-Uvin S. Genital tract
leukocytes and shedding of genital HIV type
1 RNA. Clin Infect Dis 2008; 47(9):1216–21.
Anderson BL, Cu-Uvin S. Pregnancy and
Optimal Care of HIV-Infected Patients.
Clin Infect Dis 2009; 48:449–55.
Kwara A, Rezk N, Hogan J, Burtwell H, Chapman
S, Moreira C, Kurpewski J, DeLong BS, Ingersoll J,
Caliendo AM, Kashuba A, Cu-Uvin S. Antiretroviral
drug concentrations and virologic rebound in the
genital tract of HIV-infected women on chronic
HAART. Clin Infect Dis 2008; 46:719-25.
Fischer SA. Emerging viruses in transplantation:
There is more to infection after transplant than
CMV and EBV. Transplantation 2008; 86:1327–39.
◆◆
Gautam A, Fischer SA, Yango A, et al. Suppression
of cell-mediated immunity by a donor transmitted
lymphocytic choriomeningitis virus in a kidney
transplant recipient. Transpl Infect Dis 2007; 9:339.
◆◆
Patel A, Fischer SA, Calfee R, Fadale P. Locker
room acquired methicillin-resistant staphylococcus
aureus. Orthopedics 2007; 30:532.
Gillani FS, Zaller ND, Zeller K, Rich JD, CuUvin S, Flanigan TP, Carpenter CCJ. Changes in
demographics and risk factors among persons living
with HIV in an academic medical center from
2003-2007. Med & Hlth RI 2009; 92(7), 237–43.
◆◆
Zaller N, Gillani FS, Rich JD. A model of
integrated primary care for HIV positive patients
with underlying substance use and mental
illness, CAIC. AIDS Care 2007; 19(9), 1128–33.
Stephen Gregory, M.D.
◆◆
Gehring S, Sabo E, Martin ME, Dickson EM, Cheng
C-W, Gregory SH. Laser capture microdissection
and genetic analysis of carbon-labeled Kupffer
cells. World J Gasteroenterol 2009; 15:1708–18.
◆◆
Wintermeyer P, Chewng C-W, Gehring S, Hoffman
BL, Holub M, Brossay L, Gregory SH. Invariant
natural killer T cells suppress neutrophil inflammatory
response in a mouse model of cholestatic liver
damage. Gastroenterology 2009; 136:1048–59.
Joseph I. Harwell, M.D.
◆◆
Kong BN, Harwell JI, Suos P, Lynen L, Mohiuddin S,
Reinert S, Pugatch D. Opportunistic infections and
HIV clinical disease stage among patients presenting
for care in Phnom Penh, Cambodia. Southeast
Asian J Trop Med Public Health 2007; 38:62–8.
◆◆
Sok P, Harwell JI, Dansereau L, McGarvey
ST, Lurie M, Flanigan T, Mayer KH. Patterns
of sexual behaviors of male patients prior to
testing HIV+M in a Cambodian hospital,
Phnom Penh. Sexual Health 2008; 5:353–8.
Timothy P. Flanigan
◆◆
◆◆
Flanigan TP, Payne N, Simmons E, Hyde
J, Sly K, Zlotnick C. Lessons learned from a
training collaboration between an ivy league
institution and a historically black university.
Am J of Public Hlth 2009; 99(S1): S57–60.
Kumarasamy N, Flanigan TP, Vallabhaneni S,
Cecelia AJ, Cristybai P, Balakrishnan P, Yepthomi
T, Solomon S, Carpenter CJ, Mayer KH. A reliable
and inexpensive easy CD4 assay for monitoring
HIV-infected individuals in resource-limited settings.
J Acquir Immune Defic Syndr 2007; 43(1):53–8.
Macalino GE, Hogan JW, Mitty JA, Bazerman
LB, Delong AK, Loewenthal H, Caliendo
AM, Flanigan TP. A randomized clinical trial of
community-based directly observed therapy as
an adherence intervention for HAART among
substance users. AIDS 2007; 21(11):1472–7.
◆◆
Staci A. Fischer, M.D
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Fizza S. Gillani, M.D.
Susan Cu-Uvin, M.D.
◆◆
◆
Rami Kantor, M.D.
◆◆
Chan PA, Wakeman SE, Flanigan T, CuUvin S, Kojic E, Kantor R. HIV-2 diagnosis
and quantification in high-risk patients.
AIDS Research & Therapy 2008; 5:18.
◆◆
Kantor R, Diero L, A DeLong, Kamle L, Muyonga S,
Mambo F, Emonyi W, Chan PA, Carter EJ, Hogan J,
Buziba N.. Misclassification of first-line antiretroviral
treatment failure based on immunological
monitoring of HIV infection in resource-limited
settings. Clin Infect Dis 2009; 49:454–62.
81
infectious dise ases
INFECTIOUS DISEASES FELLOWS and residents
Karen T. Tashima, M.D., Program Director
Curt G. Beckwith, M.D. Associate Program Director
Departing Fellows
Name
Medical School
Residency
Career Plans
Omega Edwards, M.D.
SUNY Downstate College of
Medicine
Norwalk Medical Center
ID Attending
Oxnard, CA
Eleni Patrozou, M.D.
University of Athens
Brown Medical School
Clinical Instructor
Miriam Hospital
Departing NIH T32 Sponsored Research Fellows
Name
Medical School
Residency
Career Plans
Nanetta Payne, M.D., Ph.D.
Jackson State University
Brown University
Assistant Professor, JSU
ChiaChing Jackie Wang, M.D. SUNY School of Medicine
Women and Infants
Internal Medicine Residency,
RIH
Kimberly Zeller, M.D.
University of Texas
Southwestern Medical School
Natividad Medical Center
Salinas Family Practice
Assistant Professor, Brown
(Memorial Hospital of RI)
Name
Medical School
Residency
Nicole Alexander, M.D.
Upstate Medical Unvirsity, NY
University Hospital at Stonybrook
Eirini Christaki, M.D.
University of Thessaloniki
Albert Einstein College of Medicine
Omega Edwards, M.D.
SUNY Downstate College of
Medicine
Norwalk Medical Center
Eleni Patrozou, M.D.
University of Athens
Brown Medical School
Current Fellows:
Current NIH T32 Sponsored Research Fellows
82
Name
Medical School
Residency
Carolina Abuelo, M.D.
Duke University School of
Medicine
Harvard Medical School
Brian Montague, D.O.
University of North Texas
Yale University
Ank Nijhawan, M.D.
University of Texas
Southwestern Medical School
University of Texas Southwestern Medical School
Amy Nunn, MSc
Harvard School of Public
Health
NA
Megan Pinkston, Ph.D.
University of Missouri
N/A
Aadia Rana, M.D.
University of Alabama
Medical School
Case Western Reserve University
a c a d e m i c y e a r s 20 08 a n d 20 09
Erna Milunka Kojic, M.D.
◆◆
Carpenter CCJ, Kojic EM: Introduction:
AIDS. Med Hlth RI 2009;92(2):228.
◆◆
Kojic EM, Wang CC, Firth JA, Gopalakrishman
G, Cu-Uvin S. Special care issues of women living
with HIV/AIDS. Med Hlth RI 2009; 92(7):229–30.
◆◆
◆◆
Kwara A, DeLong A, Rezk N, Hogan J, Burtwell H,
Chapman S, Moreira CC, Kurpewski J, Ingersoll J,
Caliendo AM, Kashuba A, Cu-Uvin S. Antiretroviral
drug concentrations and virologic rebound in the
genital tract of HIV-infected women on chronic
HAART. Clin Infect Dis 2008; 46:719–25.
Kwara A, Herold JS, Machan JT, Carter EJ.
Factors associated with failure to complete
isoniazid treatment for latent tuberculosis
infection in Rhode Island. Chest 2008; 862–868.
Kwara A, Lartey M, Sagoe KW, Xexemeku
F, Kenu E, Oliver-Commey J, Boima V, Sagoe
A, Boamah I, Greenblatt DJ, Court MH.
Pharmacokinetics of efavirenz when co-administered
with rifampin in TB/HIV co-infected patients:
pharmacogenetic effect of CYP2B6 variation.
J Clin Pharmacol 2008; 48:1032–1040.
◆◆
Mayer KH, Mimiaga MJ, Cohen D, Grasso C, Bill
R, VanDerwarker R, Fisher A. Tenofovir DF plus
Lamivudine or Emtricitabine for non-occupational,
post-exposure prophylaxis (NPEP) in a Boston
Community Health Center. JAIDS 2008; 47(4):494–9.
◆◆
Mayer KH, Bradford JB, Makadon HJ, Stall R,
Goldhammer H, Landers S. Sexual and gender
minority health: What we know and what needs to
be done. Am J of Pub Hlth 2008; 98(6):989–95.
◆◆
Mimiaga MJ, Case P, Johnson CV, Safren SA,
Mayer KH. Pre-exposure antiretroviral prophylaxis
attitudes in high-risk Boston area men who report
having sex with men: Limited knowledge and
experience but potential for increased utilization
after education. JAIDS 2009; 50(1):77–83.
Leonard A. Mermel, D.O.
◆◆
Ben-David D, Novikov I, Mermel LA. Are there
differences in hospital cost between patients with
nosocomial methicillin-resistant Staphylococcus
aureus bloodstream infection and methicillinsusceptible S. aureus bloodstream infections?
Infect Control Hosp Epidemiol 2009; 30:453–60.
◆◆
Mermel LA, Allon M, Bouza E, Craven DE et
al. Clinical practice guidelines for the diagnosis
and management of intravascular catheter-related
infections: 2009 update by the Infectious Diseases
Society of America. Clin Infect Dis 2009; 49:1–45.
◆◆
Patrozou E, Reid K, Jefferson J, Mermel LA. A
cluster of community acquired methicillin-resistant
Staphylococcus aureus infections in hospital security
guards. Infect Control Hosp Epidemiol 2009; 30:386–8.
Michelle A. Lally, M.D.
◆◆
Lally MA, Lemei KD, Bonney LE, Zimet GD.
HPV vaccination: an opportune time for HIV
testing. J Adolesc Health 2007; 40:384–5.
◆◆
Lally MA, Lemei KD, Mayer K. HIV vaccine
update: recent developments and current
trials. Med Health RI 2007; 90(10):318–20.
◆◆
Lally MA, Montstream-Quas S, Tanaka S, Tedeschi
S, Morrow K. A qualitative study among injection
drug using women in Rhode Island: attitudes toward
testing, treatment, and vaccination for hepatitis
and HIV. AIDS Pt Care STDs 2008; 22(1):53–64.
Jerome M. Larkin, M.D.
◆◆
Larkin J, Mitty J. Introduction: Lyme
disease. Med Health RI 2008; 91:208–9.
◆◆
Larkin JM, Ticks and tick related illness.
Med Health RI 2008; 91:209–11.
◆◆
Larkin JM, Lyme disease in children and
pregnant women. Med Health RI 2008; 91:212.
Steven P. Larosa, M.D.
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Kenneth H. Mayer, M.D.
Awewura Kwara, M.D.
◆◆
◆
Maria D. Mileno, M.D.
◆◆
Ain DL, Patrozou E, Feller E, de la Monte
S, Mileno M. Intracerebral aspergillosis.
Med Health RI 2008; 91(1):25–6.
Jennifer A. Mitty, M.D.
◆◆
Mitty JA, Bazerman, LB, Selwyn KS, Beckwith CG,
Zaller ND, Rich JD. Decrease in the proportion
of injection drug use- related HIV/AIDS in
Massachusetts, New York, Connecticut and Rhode
Island. AIDS Reader 2008; 18(12):596–600.
◆◆
Blood E, Bazerman L, Cu-Uvin S, Beckwith C,
Mitty JA. Pregnancy trends in HIV (+) refugees
in Rhode Island. AIDS Care 2009; 21(2):207–11.
LaRosa SP, Opal SM. Sepsis strategies in
development. Clin Chest Med 2008; 29(4):735-47.
83
infectious dise ases
Marguerite A. Neill, M.D.
◆◆
◆◆
Pop-Vicas A, Mitchell S, Kandel R, Schreiber
R, D’Agata E. Multidrug-resistant gram-negative
bacteria among long-term care residents:
prevalence and risk factors. J of the American
Geriatrics Society 2008; 56(7):1276–80.
◆◆
Pop-Vicas A, Strom J, Stanley K, D’Agata EMC.
Multidrug-resistant gram-negative bacteria
among patients requiring chronic hemodialysis.
Clin J Am Soc Nephrol 2008; 3(3):752–8.
Pop-Vicas A, Neill MA. Clostridium difficile: the
increasingly difficult pathogen. Crit Care 2008; 12:114.
Amy Nunn, ScD.
◆◆
Nunn A, Fonseca E, Gruskin S. Changing
global essential medicines norms to improve
access to AIDS treatment: Lessons from
Brazil. Global Public Health 2009; 4(2):1–17.
◆◆
Nunn A, Da Fonseca E, Bastos F, Gruskin S. AIDS
treatment in Brazil: Local and global impacts and
challenges. Health Affairs 2009; 28(4):1103–13.
◆◆
Nunn A, Zaller N, Dickman S, Trimbur C,
Nijhawan A, Rich J. Methadone and buprenorphine
subscribing practices: Results from a nationwide
survey. Drug and Alcohol Dependence 2009; 105:1–2.
Josiah D. Rich, M.D.
◆◆
Martin TM, Rich JD. Fatal HIV encephalitis
in HIV-seronegative patients. Emerg Infect Dis
2009; 15(1):129–31. PMCID: PMC2660676
◆◆
Zaller N, Thurmond P, Rich JD. Limited spending:
an analysis of correctional expenditures on
antiretrovirals for HIV infected prisoners. Pub Health
Reports 2007; 122(1):49–54. PMCID: PMC1802113
◆◆
Zaller N, Holmes L, Dyl A, Mitty JA, Beckwith
CG, Flanigan TP, Rich JD. Linkage to treatment
and supportive services among HIV-positive
ex-offenders in Project Bridge. J Health Care
Poor Underserved 2008; 19(2):522–31.
Steven M. Opal, M.D.
◆◆
Christaki E, Opal SM. Is the mortality rate
for septic shock really decreasing? Current
Opinion in Critical Care 2008; 14:580–6.
◆◆
Cinel I, Opal SM. Molecular biology of
inflammation and sepsis: A primer. Critical
Care Medicine 2009; 37(1):291–304.
◆◆
Opal SM, Patrozou E. Translational research in
sepsis: logical deductive reasoning or “mission
impossible?” Critical Care Medicine 2009; 37:S10-5.
Lynn E. Taylor, M.D.
◆◆
Taylor LE, Mayer KH. Acute hepatitis
C virus infection in an HIV clinic and
in community settings. Gastroenterology
2009; 136(7):2411–2. PMID: 19409986.
◆◆
Taylor LE. HIV/viral hepatitis Coinfection:
The immunology center experience.
Medicine Health RI 2009; 92(7):234–6.
Eleni Patrozou, M.D.
◆◆
Opal SM, Patrozou E. Translational research in
the development of novel sepsis therapeutics:
Logical deductive reasoning or mission impossible?
Crit Care Med 2009; 37(1 Suppl):S10-5.
◆◆
Patrozou E, Reid K, Mermel L, Jefferson J. A
cluster of community acquired methicillinresistant Staphylococcus aureus infections in
hospital security guard. Infection Control and
Hospital Epidemiology 2009; 30(4):386–8.
◆◆
Patrozou E, Rich H, Sweeney J. Human
babesiosis requiring exchange transfusion: A
case series from Rhode Island hospitals. J
Clinical Apheresis 2009; 24(3):97–105.
Aurora Pop-Vicas, M.D.
◆◆
84
Pop-Vicas A, Gravenstein S, Lu B, D’Agata
EMC. The influx of multidrug-resistant gramnegative bacteria into the hospital setting and
the role of the elderly. Infection Control and
Hospital Epidemiology 2009; 30(4):325–31.
Nickolas Zaller, M.D.
◆◆
Zaller N, Thurmond P, et al. Limited Spending:
An analysis of correctional expenditures on
antiretrovirals for HIV-infected prisoners.
Public Health Reports 2007; 121(1): 49–54.
◆◆
Zaller N, Gillani F et al. A model of integrated
primary care for HIV positive patients
with underlying substance use and mental
illness. AIDS Care 2007; 19(9):1128–33.
◆◆
Zaller N, Holmes L, et al. Linkage to
treatment and supportive services among
HIV(+) ex-offenders. J Healthcare for the Poor
and Underserved 2008; 19(2):522–531.
a c a d e m i c y e a r s 20 08 a n d 20 09
RESEARCH
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$1,975,081
$1,967,673
$523,331
$413,061
$2,498,412
$2,380,734
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$9,056,053
$8,820,045
$1,376,627
$1,343,647
$10,432,680
$10,163,692
S ELEC T ED
B A S IC RE S EARCH
S ELEC T ED
CLINICAL RE S EARCH
Stephen H. Gregory, Ph.D.
Andrew W. Artenstein, M.D.
◆◆
Neutrophil-macrophage interactions govern
liver immunity, National Institute of Diabetes
and Digestive and Kidney Diseases
◆◆
Francisella Tularensis: Innate resistance to inhalation,
National Institute of Allergy and Infectious Diseases
◆◆
Tulerimia Vaccine, Epivax/National Institute
of Allergy and Infectious Diseases
◆◆
Anti Core Vaccine for Tulerimia, Harvard/National
Institute of Allergy and Infectious Diseases
◆◆
Dendritic cell-based vaccination against
Hepatitis C, URI/National Institute
of Allergy and Infectious Diseases
◆◆
Multi-intracellular pathogen epitope
based vaccine, URI/National Institute
of Allergy and Infectious Diseases
◆◆
Curt G. Beckwith, M.D.
◆◆
Comprehensive HIV testing strategies for
jails, National Institute of Drug Abuse
◆◆
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) Developmental grant, National
Institute of Allergy and Infectious Diseases
◆◆
MAP’s Targeted HIV Outreach Program: Project
Faith and Sara’s Light, MAP Alcohol/Drug
Rehab Services/Centers for Disease Control
Charles C.J. Carpenter, M.D.
◆◆
Lifespan/Tufts/Brown Center for AIDS
Research (CFAR), National Institute
of Allergy and Infectious Diseases
◆◆
Lifespan/Tufts/Brown Center for AIDS
Research (CFAR), ARRA supplement, National
Institute of Allergy and Infectious Diseases
◆◆
The Study to Understand the Natural History of HIV/
AIDS in the Era of Effective Antiretroviral Therapy
(SUN), Centers for Disease Control and Prevention
Bharat Ramratnam, M.D.
◆◆
COBRE: New Stem Cell Biology, Roger Williams
Hospital/National Center for Research Resources
◆◆
Creation and testing of the advanced system for
lentivector medicated transduction of hematopoietic
stem cells and expression of anit HIV-1 shRNAs, US
Civilian Research and Development Foundation
◆◆
Transient gene therapy for inflammatory bowel
disease, Eli and Edythe Broad Foundation
◆◆
Novel HIV-1 microbicides, National Institute
of Allergy and Infectious Diseases
◆◆
Lab secreting CVn as a microbicide,
University of Pittsburgh/National Institute
of Allergy and Infectious Diseases
◆◆
Overcoming HIV-1 resistance to RNA interference,
National Institute of Allergy and Infectious Diseases
◆◆
COBRE, Molecular Core, National
Center for Research Resources
◆◆
SIRNA Microbicides, National Institute
of Allergy and Infectious Diseases
Center for Biodefense and Emerging Pathogens,
Centers for Disease Control and Prevention
E. Jane Carter, M.D.
◆◆
Presidential Expansion Project for AIDS Relief, Indiana
University/US Agency for International Development
◆◆
HIV/AIDS Prevention, Kericho Kenya,
Henry Jackson Foundation
Susan Cu-Uvin, M.D.
◆◆
Antiviral Therapy and HIV in the Genital
Tract of Women (RO1), National Institute
of Allergy and Infectious Diseases
◆◆
Antiviral Therapy and HIV in the Genital tract
of Women (RO1), Minority supplement, National
Institute of Allergy and Infectious Diseases
85
infectious dise ases
◆◆
◆◆
◆◆
Antiviral Therapy and HIV in the Genital Tract
of Women (RO1), K24, National Institute
of Allergy and Infectious Diseases
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR), HIV and Women’s Core, National
Institute of Allergy and Infectious Diseases.
◆◆
Genital Tract HIV Shedding in Cambodian
Women, Fogarty International Center
Leah Holmes, LICSW
◆◆
Outreach and Medical Care for HIV+ Offenders,
Health Resources and Services Administration
– Special Project of National Significance
◆◆
Outreach and Intensive Care Management for
HIV+ Ex-offenders, RI Department of Health/
Health Resources and Services Administration
Interdisciplinary Framework in Global Health at
Brown University, Fogarty International Center
Timothy P. Flanigan, M.D.
◆◆
Directly observed therapy (D.O.T) for TB and
HIV in Kenya, Fogarty International Center
◆◆
Neurocognitive Consequences of HIV/AIDS in
south India, National Institute of Mental Health
◆◆
◆◆
HIV and Other Infectious Consequences of
Substance Abuse, National Institute on Drug Abuse
HIV Diversity and Drug Resistance in
Western Kenya, Rhode Island Foundation
◆◆
HIV and Other Infectious Consequences of
Substance Abuse – Correctional Supplement,
National Institute on Drug Abuse
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) – Developmental Grant, National
Institute of Allergy and Infectious Diseases
◆◆
HIV-1 Drug Resistance in Different Subtypes,
National Institute of Allergy and Infectious Diseases
◆◆
Kantor, Rami, HIV in Kenya Crisis,
Friendship Foundation
◆◆
◆◆
◆◆
◆◆
◆◆
◆◆
◆◆
◆◆
◆◆
The Brown Initiative in HIV and AIDS
Clinical Research for Minority Communities,
National Institute of Mental Health
Center for Drug Abuse and AIDS
Research, Drug User Resources Core, Tufts/
National Institute on Drug Abuse
◆◆
Rami Kantor, M.D.
Awewura Kwara, M.D.
◆◆
Cognitive Performance and Diffusivity in
HIV Patients, Brigham and Women’s Hospital/
National Institute of Mental Health
Concurrent HAART and Tuberculosis
Treatment: Drug To Drug Interactions, National
Institute of Allergy and Infectious Diseases
◆◆
Services for HIV+ Rhode Islanders,
Thundermist Health Clinic/Health
Resources and Services Administration
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) – Developmental Grant, National
Institute of Allergy and Infectious Diseases
◆◆
Epidemiological Aspects of Tuberculosis in
Rhode Island, Rhode Island Foundation
An Evaluation of Innovative Methods for
Integrating Buprenorphine Opioid Abuse
Treatment in HIV Primary Care Settings,
Health Resources and Services Administration
– Special Project of National Significance
Enhancing Linkage to HIV Primary Care
and Services in Jail Settings, Health Resources
and Services Administration – Special
Project of National Significance
Enhancing Linkage to HIV Primary Care and
Services in Jail Settings - Supplemental Funding,
Health Resources and Services Administration,
Special Project of National Significance
Planning Grant for the Brown Institute
for Clinical and Translational Science,
National Center for Research Resources
Mary M. Flynn, Ph.D., R.D., L.D.N.
86
Joseph I. Harwell, M.D.
The Study of Diet and its Relation to Breast
Cancer, Komen Breast Cancer Foundation
Michelle A. Lally, M.D.
◆◆
Vaccine Trials Network, Harvard/National
Institute of Allergy and Infectious Diseases
◆◆
Nucleic Acid Assays for Diagnosis of
HIV Infection Anticipation of an HIV
Vaccine, Henry Jackson Foundation
◆◆
Leadership Group for a Global HIV Vaccine
Clinical Trials Network, Fred Hutchinson
Cancer Research Center/ National Institute
of Allergy and Infectious Diseases
◆◆
Adolescent Trials Network Coordinating Center,
University of Alabama/National Institute of
Child Health and Human Development
Kenneth H. Mayer, M.D.
◆◆
Optimizing HIV Care In Less Developed Countries,
National Institute of Allergy and Infectious Diseases
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Scholars Program at YRG Care and Moi Medical
School, Fogarty International Center
◆◆
Midcareer Investigator Award in Patient Oriented
Research, National Institute on Drug Abuse
◆◆
Lifespan/Tufts/Brown Center for AIDS
Research (CFAR) – Prevention Core, National
Institute of Allergy and Infectious Diseases
◆◆
Ryan White Part C: Capacity Development,
Health Resources and Services Administration
◆◆
◆◆
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) – International Supplemental Funding,
National Institute of Allergy and Infectious Diseases
Ryan White Part C, Health Resources
and Services Administration
◆◆
Ryan White Part C: Capacity Building to Develop
Standard Electronic Client Information Data Systems,
Health Resources and Services Administration
◆◆
The Rhode Island Re-Entry Partnership, Drug and
Alcohol Treatment Assoc. of RI/Substance Abuse
and Mental Health Services Administration
◆◆
A Randomized Trial of Continued Methadone
Treatment Maintenance vs. Detoxification
in Jail, National Institute on Drug Abuse
◆◆
Brief Intervention for Prescription and
Other Drugs, Rhode Island Hospital/
National Institute on Drug Abuse
◆◆
Feasibility of Pharmacy Based HIV Interventions
among IDUs, Fenway Community Health/
National Institute on Drug Abuse
◆◆
Substance Abuse Treatment and HIV/
AIDS Services, Substance Abuse and Mental
Health Services Administration
◆◆
New England AIDS Education and Training Center,
UMass/Health Resources and Services Administration
◆◆
STD/HIV Prevention Training Center, MA
D.O.H/Centers for Disease Control
◆◆
AIDS International Training and Research
Program, Fogarty International Center
◆◆
Cancer training and Resource Development in
Western Kenya, Fogarty International Center
◆◆
Program for Enhanced HIV Prevention Training of
ICMR Researchers, Fogarty International Center
◆◆
T Vaginalis host Interactions in Relevance
to Inflammatory Sequelae, Brigham and
Women’s Hospital/National Institute
of Allergy and Infectious Diseases
◆◆
Cervical Cancer Screening for HIV+ Women
in Kenya, Fogarty International Center
Jennifer A. Mitty, M.D.
◆◆
D.O.T and Prevention for HIV+ Persons Leaving
Prison, National Institute on Drug Abuse
Steven M. Opal, M.D.
◆◆
◆◆
Role of Inter-alpha Inhibitors in Anthrax Intoxication,
National Institute of Allergy and Infectious Diseases
Microfluidic Platform for Rapid Influenza
Subtyping (ARRA Subcontract), National
Institute of Allergy and Infectious Diseases
Karen T. Tashima, M.D.
◆◆
Lynn E. Taylor, M.D.
◆◆
Buprenorphine as a bridge to HCV treatment
for HIV/HCV Co-infected opioid users,
National Institute on Drug Abuse
◆◆
Stabilize Addiction/Affect, Begin Inmates
Interferon for HCV of Liver (STAABIHL),
National Institute on Drug Abuse
◆◆
Center for Drug Abuse and AIDS Research – Liver
Function Core, National Institute on Drug Abuse
◆◆
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) – Developmental Grant, National
Institute of Allergy and Infectious Diseases
◆◆
Identifying Acute Hepatitis C Virus
among at risk hard to reach HIV+
populations, Rhode Island Foundation
Aurura Pop-Vicas, M.D.
◆◆
Clinical and Molecular Epidemiology of Clostridium
deficile-Associated Disease in Long-Term Care
Facility Residents, The Rhode Island Foundation
Bharat Ramratnam, M.D.
◆◆
Lifespan/Tufts/Brown Center for AIDS
Research (CFAR) – Virology Core, National
Institute of Allergy and Infectious Diseases
Josiah D. Rich, M.D.
◆◆
Opiate Replacement Therapy at Release from
Incarceration, National Institute on Drug Abuse
◆◆
Opiate Replacement Therapy at Release
from Incarceration - Supplement,
National Institute on Drug Abuse
AIDS Clinical Trials Group – Clinical Research
Site, Massachusetts General Hospital/ National
Institute of Allergy and Infectious Diseases
Nickolas Zaller, M.D.
◆◆
Lifespan/Tufts/Brown Center for AIDS Research
(CFAR) – Developmental Grant, National
Institute of Allergy and Infectious Diseases
87
kidney disease and hypertension
K IDNEY DI S EA S E
AND HYPER T EN S ION
OVERVIE W
C
linical, basic research, clinical research and
educational programs in the Division of
Kidney Disease and Hypertension continue
to evolve and expand.
Clinically, the Division provides consultative services
to inpatients with kidney disease or hypertension at
Rhode Island Hospital, The Miriam Hospital and the
Providence Veterans Affairs Hospital, to outpatients in
our offices or clinics at all three hospitals, at the Hallett
Diabetes Center and at the University Medicine Foundation satellite offices on Governor Street in Providence,
on East Avenue in Pawtucket, and on Centerville Road
in Warwick. At Rhode Island Hospital, the Division is
an integral part of the kidney and pancreas transplant
program, which is a joint medical, surgical effort. Described below, the transplant team provides outstanding,
innovative clinical service to patients with end stage
kidney disease and conducts state of the art clinical/
translational research on various topics related to transplantation. Division faculty also provide clinical and
administrative leadership for the inpatient dialysis units
at the Rhode Island Hospital, the Miriam Hospital,
and the Veterans Affairs Hospital, and four outpatient
dialysis units in the Providence metropolitan area.. The
inpatient dialysis units at Rhode Island Hospital and
The Miriam Hospital are particularly busy and perform
approximately 8,000 treatments per year, primarily to
hospitalized patients with acute or chronic renal disease;
not only in the dialysis units themselves, but also in the
intensive care units at both institutions. The Dialysis
Unit at Rhode Island Hospital also provides therapeutic
plasma exchange treatment to patients with diverse
types of kidney, hematological and neurological diseases.
The Division has experienced steady growth in the size
of its chronic dialysis program, which began in about
2000 and now includes over 250 patients with end stage
renal disease (ESRD) treated with hemodialysis and
peritoneal dialysis. In addition to directing the inpatient
units at Rhode Island and the Miriam Hospital, Division faculty are medical directors of the dialysis unit at
the Veterans Affairs Hospital and at two privately owned
outpatient dialysis units in North Providence and in
88
Douglas Shemin, M.D., Associate Professor of Medicine
Interim Director, Division of Kidney Disease and Hypertension
Warwick respectively. The Division provides medical
leadership for a newly built, state of the art dialysis
unit owned by Rhode Island Hospital near the hospital
complex; this unit will focus on home dialysis therapies.
In all of these venues, division faculty and fellows strive
to provide high quality and innovative care to patients
with ESRD. Nocturnal dialysis is one such innovative
program, initiated and overseen by Dr. Douglas Shemin
that is ongoing. In this technique, patients receive a
long, 7.5-hour dialysis treatment overnight, while they
are sleeping in the dialysis facility. This form of therapy
provides almost twice as much dialysis as is typically
prescribed for kidney patients, and is associated with
better control of metabolic and physiologic markers of
disease. This therapy may be particularly well suited to
younger patients and/or those that are either working
or attending school, as functional status is significantly greater in patients on nocturnal as compared to
standard dialysis. Whether or not nocturnal dialysis also
improves long-term outcomes for patients with kidney
failure is the subject of intense interest and investigation.
The Division has successful, externally funded programs
in both basic and clinical research. The clinical research
program is notable in that two of the largest NIH funded
clinical trials in patients with chronic kidney disease
are lead by Division faculty. Dr. Andrew Bostom is the
Principal Investigator for “The Folic Acid for Vascular
a c a d e m i c y e a r s 20 08 a n d 20 09
Outcome Reduction in Transplantation (FAVORIT)”
study. FAVORIT is a multicenter, randomized, doubleblind controlled clinical trial sponsored by the National
Institute of Diabetes & Digestive & Kidney Diseases.
The 8-year trial was designed to determine whether treatment with a standard multivitamin augmented with high
doses of folic acid, vitamin B6 and vitamin B12 reduces
the rate of cardiovascular disease outcomes in renal transplant (graft) recipients relative to participants receiving a
similar multivitamin that contains no folic acid and lower
(i.e., Estimated Average Requirement) amounts of vitamins B6 and B12. With 4000 participants drawn from 20
major North American, Canadian, and South American
renal transplant centers, FAVORIT was the largest study
of CVD prevention ever undertaken in the chronic renal
disease; it recently ended, but the data bank is expected
to be used extensively in the coming years to examine
clinical and other variables in the transplant population
and their link to cardiovascular morbidity and mortality.
Dr. Lance Dworkin is the overall leader and study chair
for the CORAL trial, which is currently underway at
approximately 90 enrolling centers around the United
States, and internationally in Canada, Australia, New
Zealand, Brazil and Argentina. The CORAL study is
comparing the effects of renal artery angioplasty and
stenting with medical therapy versus optimal medical
therapy alone on combined cardiovascular and renal
outcomes in 1100 patients with atherosclerotic renal vascular disease and hypertension. The study was funded by
the National Heart Lung and Blood Institute beginning
April, 2004 and has a combined budget of approximately $30 million dollars for the 6 year period during which
the study will be conducted. With approximately 300
patients entered into the randomized phase so far, the
study is well underway and has already attracted considerable interest. Other areas of active clinical investigation include anemia in chronic kidney disease, dialysis
adequacy and outcomes in acute and chronic renal
failure (Dr. Douglas Shemin) accurate determination of
glomerular filtration rate and the association between
mild to moderate renal function and cardiovascular
disease ( Dr. Susie Hu), hypertension, chronic renal
disease and cardiovascular disease (Dr. Lance Dworkin),
diabetic nephropathy (Dr. John O’Bell and Dr. George
Bayliss), the effect of protocol driven care in determination of outcomes in chronic kidney disease (Dr. Andrew
Cohen) and transplantation medicine by (Dr.Reginald
Gohh and Dr. Angelito Yango)
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
The laboratory research program is directed by Dr. Shougang Zhuang, assisted by Dr. Rujun Gong. Dr. Zhuang’s
laboratory is interested in the mechanisms of renal regeneration after injury and in developing therapeutic agents
that promote renal recovery after acute kidney injury
(AKI). His current projects are focused on determining
the intracellular signaling events critical for renal epithelial cell dedifferentiation and migration after injury, as
well as defining the role of suramin in stimulating renal
epithelial cell regeneration and accelerating recovery of renal function following ischemia/reperfusion-induced AKI.
Dr. Zhuang has recruited two post-doctoral fellows to
work with him on these projects and is also providing opportunities for residents, fellows and students to gain experience in basic research. Dr. Gong’s laboratory focuses
on effects of hepatocyte growth factor on matrix turnover
and as a modulator of renal inflammation, both processes
contributing importantly to progression of chronic renal
disease. He has examined other signaling molecules important in these processes, which has resulted in a steady
stream of first rate, peer-reviewed original reports in high
impact journals. Dr. Gong was also recently funded by
Questcor to evaluate the effect on adrenocorticotropic
hormone (ACTH) on an animal model of focal and
segmental glomerulosclerosis; this research has important clinical implications as well. He also has recruited a
postdoctoral research fellow and his lab serves as a site for
fellow, resident, and student instruction.
The Division also works closely with the Division of
Pediatric Kidney Disease in the area of education. Fellows in the Division learn and work under the supervision of Drs. Mohammed Faizan and Sharon Su of the
Brown pediatric faculty during rotations in pediatric
nephrology. The pediatric nephrologists also actively
participate in the renal physiology and pathophysiology
courses, directed by the Division, for undergraduate
medical students at Brown In addition to the Department of Pediatrics, the Kidney Division also has a very
collaborative working relationship with our three renal
and pancreas transplant surgeons, Dr. Anthony Monaco,
Dr. Paul Morrissey, and Dr. Kevin Charpentier, who
round frequently with fellows rotating on the transplant service, provide lectures and attend conferences
in the division. Three members of the Department of
Pathology also have extensive interactions with our
program. Dr. Alfredo Esparza is an expert renal pathologist. He and Dr. Li Wang review native and transplant
renal biopsies for the division, and provide hours of
instruction to fellows and faculty on the pathology of
89
kidney disease and hypertension
kidney disease. Dr. Abdalla Rifai is director of Clinical Immunology, and expert on the pathogenesis of
glomerular disease, especially IgA nephropathy, and an
integral member of the basic laboratory research team.
Finally, Dr. Staci Fischer is a member of the Division of
Infectious Disease in the Department of Medicine, but
also our dialysis and transplant infectious disease expert.
Her office and clinic are located in the transplant unit of
the Kidney division and she works, rounds and instructs
fellows and residents on this complex topic.
The affiliation remains strong between the Division of
Kidney Disease and Hypertension at Brown and the
Research Institute of Nephrology in Nanjing, under
the auspices of the Renal Sister Center Program of the
International Society of Nephrology. This program
pairs kidney centers in developing countries with
established programs in the United States or Europe,
in order to facilitate the development worldwide of
clinical and academic programs in nephrology. The
affiliation between the nephrology programs at Nanjing
University and Brown began in May 1997. For the
past 5 years, fellows from Nanjing have spent 1–2 years
working in the kidney division laboratories at Brown.
More recently, there have been visits to Brown by
faculty from Nanjing, including a 3 day visit in 2008 by
Professor Zhi-Hong Liu and Professor Lei-shi Li, the
directors of the Research Institute of Nephrology, and
a 3 month observership of our clinical and training
programs in nephrology at Brown earlier this year by
Dr. Honglang Xie, who is the director of intensive care
nephrology at the Institute in Nanjing. In 2008 Drs.
Lance Dworkin and Reginald Gohh traveled to Nanjing
to teach and lecture at the Institute, and Drs. Lance
Dworkin, Douglas Shemin, and Andrew Cohen spoke
at international symposia sponsored by the Institute in
2009. The Research Institute of Nephrology at Nanjing
is the premier kidney program in China. It occupies
a modern 7 story building on the campus of Jingling
Hospital, which has nearly 2000 inpatient beds, as well
as a brand new outpatient facility. The Institute also
contains large modern clinical and research laboratories
with state of the art equipment for modern molecular
and cell biology. Major areas of investigation include
studies on the pathogenesis and treatment of glomerular
diseases, including systemic lupus erythematosis and
IgA nephropathy, and diabetic nephropathy. One goal
of the Sister Center program is to provide opportunities for nephrology fellows to visit China and observe
nephrology practice and research in an international
90
setting. In addition, in 2009, the Division’s application
to join a second Sister Center program, this time with
the Department of Kidney Diseases at Moi University
in Eldoret, Kenya, was approved by the International
Society of Nephrology; and we expect that this relationship will also develop and involve visits back and forth
between the two institutions, with opportunities for
joint research and educational programs.
Division faculty are actively engaged in providing
nephrology education to medical students, residents,
clinical and post-doctoral research fellows. Division
faculty teach renal physiology, pharmacology and
pathophysiology to medical students in both the lecture
and small group format each year. The nephrology
portion of the second year pathophysiology course is
co-directed by Drs. Andrew Cohen and Susie Hu and
receives highly favorable reviews each year. Members of
the faculty serve as attending physicians on the inpatient
dialysis, renal consultation, and renal transplant service
at the Rhode Island Hospital, the Miriam Hospital, and
the Veterans Affairs Hospital, rounding with fellows,
residents and students daily for 12 months per year. The
nephrology fellowship began at Rhode Island Hospital
in 1966 and has been in existence for over 40 years. Ably
directed by Dr. Gary Abuelo for many years, it is a
highly competitive program that attracts approximately
200 applicants each year, including many internal applicants from our medicine residency, for its three to
four training slots per year. The fellowship is a two year
program that includes 18 months of clinical education
and 6 months of clinical or laboratory research. The
program boasts a 100% nephrology board pass rate and
our graduates are highly sought after for both clinical
and academic positions. Graduates of the program are
currently working in academic and clinical nephrology
positions in 23 states and 4 countries. In addition to the
regular fellowship program leading to board certification, the division also accepts post-doctoral fellows
seeking training in basic, laboratory research. The laboratory research program currently provides training to
three post-doctoral fellows, working with Drs. Zhuang,
Gong and Dworkin. The positions are both internally
and externally funded. One slot is typically filled by an
individual from our sister center in Nanjing. Past postdoctoral fellows have gone on to faculty positions in the
United States and internationally including, Dr. Rujun
Gong in our Division.
a c a d e m i c y e a r s 20 08 a n d 20 09
T RAN S PLAN TAT ION
The Division of Organ Transplantation remains one of
the busiest and most aggressive centers in New England. Since the inception of the program in 1997, close
to 800 kidney transplant procedures have been performed at Rhode Island Hospital, averaging between
50–80 transplants per year. 46% of the transplants are
from live donors; one of the highest percentages in
the United States. It is also among only five centers
in New England that currently offers pediatric kidney
transplantation. The center follows a cadre of over 1000
transplant recipients, which accounts for over 3000
clinic visits to the transplant nephrologists at Rhode
Island Hospital each year.
In 2003, pancreas transplantation was introduced to the
program. Diabetics with frequent insulin reaction as well
as those poorly controlled on insulin are ideal candidates
as this procedure markedly improves quality of life.
Pancreas and kidney transplantation may be performed
simultaneously when diabetes is cause of kidney failure or,
after a successful kidney transplantation, to prevent progressive injury to the kidney from uncontrolled diabetes.
The center provides a multidisciplinary approach to
patient care through a comprehensive group of medical/
surgical specialists, nurses, pharmacists, social workers
and other support services. Overseeing the team is Dr.
Reginald Gohh, the medical director of the program
and an Associate Professor of Medicine at Brown University Medical School, assisted by Drs. Angelito Yango,
Terri Montague, and Christopher Cosgrove (transplant
nephrology), Dr. Staci Fischer (transplant infectious
diseases) Dr. Jodi Underwood (transplant psychiatry),
and Dr. James Beaulieu (transplant pharmacology).
T RAN S PLAN T RE S EARCH
The Division of Organ Transplantation is at the forefront of critical advances in transplantation including the use of donor bone marrow cell infusions and
newer biological agents to reduce allograft rejection
and immunosuppressive drug requirements. The center
continues to be an active participant in national and
international trials evaluating the efficacy of various
drug regimens in improving outcomes, reducing rejection rates and enhancing quality of life. The center has
recently instituted protocols for reducing alloantibody
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
levels in highly sensitized patients using intravenous
immunoglobulins, plasmapheresis and anti-CD20 antibodies. Residents and fellows are actively involved in
several basic and clinical researches in the division. Dr.
Reginald Gohh has been involved in investigating the
role of preemptive plasmapheresis in preventing recurrent FSGS in renal transplant recipients. In collaboration with Dr. Fatemah Aklaghi of University of Rhode
Island, College of Pharmacy, Dr Gohh is also investigating the pharmacokinetics of mycophenolate mofetil in
diabetic renal transplant recipients. Dr. AngelitoYango
has introduced a program for protocol renal biopsies to
monitor early stages of rejection and chronic allograft
nephropathy in renal transplant recipients. The center
performs 70-90 bedside ultrasound guided renal transplant biopsies a year and this has been a valuable tool
in immunosuppression management. Dr. Yango is also
investigating the role of hepatocyte growth factors as a
non invasive indicator for allograft injury and rejection.
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Lance D. Dworkin, M.D., Chair of Medicine (Interim)
Andrew Cohen, M.D
Associate Professors
Douglas Shemin, M.D., Director
J. Gary Abuelo, M.D.
Andrew G. Bostom, M.D., M.S.
Reginald Gohh, M.D.
Shougang Zhuang, M.D., Ph.D.
Assistant Professors
George Bayliss, M.D.
Rujun Gong, Ph.D.
Susie Lee Hu, M.D.
Terri L. Montague, M.D.
John O’Bell, M.D.
Angelito Yango, Jr., M.D.
Volunteer Clinical Faculty
Assistant Professors
Jeffrey Clement, M.D.
Christopher Cosgrove, M.D.
Eikin O. Estrada, M.D.
Thomas Krahn, M.D.
91
kidney disease and hypertension
George Lee, M.D.
Jonah Licht, M.D.
Michael Thursby, D.O.
Richard Cottiero, M.D.
Raymond Endreny, M.D.
Charles E. McCoy, M.D.
Mark Siskind, M.D.
David C. Yoburn, M.D.
Instructors
Jeffrey D. Horowitz, M.D.
Ildiko Medve, M.D.
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
◆◆
Schol arly Activities
◆◆
American Society of Nephrology, Hypertension
Advisory Group, 2007, 2008, 2009
◆◆
Chair, American Society of Nephrology, Abstract
Review Section on Clinical Hypertension, 2008
◆◆
Section Editor, Suki & Massry’s Therapy of Renal
Diseases and Related Disorders, 4th Edition, 2008
Reginald Gohh, M.D.
Invited Pr esentations
◆◆
Andrew Cohen, M.D.
Honors and awards
◆◆
Dean’s Excellence in Teaching Award, Alpert
Medical School of Brown University, 2009
Lance D. Dworkin, M.D.
Honors And Awards
◆◆
Honorary Professor, Jinling Hospital,
Nanjing University School of Clinical
Medicine, Nanjing, China, 2007–2010
Invited Pr esentations
◆◆
◆◆
American Society of Nephrology 40th Annual
Meeting and Scientific Exposition. Treatment
of Renal Artery Stenosis:Medical vs. Vascular
Intervention. San Francisco, CA. November 3, 2007.
◆◆
Cardiovascular Research Technologies 2009. We
Really Have Enough Information Now to Stent
Renal Arteries? Washington, DC, March 6, 2009
◆◆
University of Hawaii East Continuing Medical
Education Conference. Visiting Professor.
Honolulu, HI, March 23–27, 2009
◆◆
92
Centers for Medicare and Medicaid Services and
Agency for Healthcare Forum, Invited Presenter,
National Public Forum project by the Duke
Evidence-Based Practice Center entitled “Horizon
scan: To what extent do changed in third-party
payment policies affect clinical trials and the evidence
base?” Baltimore, M.D., September 20, 2007
Moi University School of Medicine, Visiting Professor.
“Use of Antihypertensive Agents in CKD”, “Acid
Base I and II”, Disorders of Water: Hypernatremia
and Hyponatremia” and “Principles of Dialysis”.
Eldoret, Kenya, Africa, August 10–27, 2009
Nanjing University , Forefronts in Glomerular
Diseases, Nanjing Forum. “Ischemic Nephropathy:
2009” and Slowing the Progression of CKD: Beyond
Hemodynamics and the Renin-Angiotension
System”. Nanjing, China, September 16–21, 2009
“Update in recurrent Focal and Segmental
Glomerulosclerosis in the Renal Transplant Recipient”,
Jinling Hospital, Nanjing, China, August 2008
John W. O’Bell, M.D.
Honors And Awards
◆◆
Dean’s Excellence in Teaching Award, Alpert
Medical School of Brown University, 2008
◆◆
Beckwith Family Award for
Outstanding Teaching, 2009
Douglas Shemin, M.D.
Honors And Awards
◆◆
Chairman of the Board of Directors, End Stage Renal
Disease Network of New England, 2006–2009
◆◆
Beckwith Family Award for Outstanding Teaching,
Alpert Medical School of Brown University, 2009
◆◆
Dean’s Excellence in Teaching Award, Alpert
Medical School of Brown University, 2009
Invited pr esentations
◆◆
“Adequacy of Dialysis in Acute Kidney Injury”, “The
Importance of Residual Renal Function in Patients
Treated with Hemodialysis”, and “Dialysis in the
United States of America”, International Blood
Purification Symposium, Nanjing, China, May 2009
Angelito Yango, M.D.
Honors And Awards
◆◆
Dean’s Excellence in Teaching Award, Alpert
Medical School of Brown University, 2008
Shougang Zhuang, M.D., Ph.D.
Invited Pr esentations
◆◆
“Psychosocial Aspects of the Dialysis
Patient”, Central South University Xiangya
Medical School, Haikou, China, 2008
a c a d e m i c y e a r s 20 08 a n d 20 09
S ELEC T ED P U B LICAT ION S
◆◆
Patel, CG, Harmon M, Gohh RY, et al.
Concentrations of mycophenolic acid and
glucoronide metabolites under concomitant
therapy with cyclosporine or tacrolimus.
Ther Drug Monitor 2007; 29(1):87–95.
◆◆
Mendonza AE, Gohh RY, Wang LJ et al. Blood
and plasma pharmacokinetics of cyclosporine
in diabetic kidney transplant recipients. Clin
Pharmacokinet 2008; 47:733–742.
◆◆
Yango A Gohh RY, Wang LJ et al. The utility
of 6 month protocol biopsy under modern
immunosuppression. Clin Neph 2008: 70:490–495.
Abuelo JG. Normotensive ischemic acute renal
failure. N Engl J Med 2007; 357:797–805
George Bayliss, M.D.
◆◆
Bayliss G, Danzinger J. Nocturnal versus
conventional hemodialysis. Some current issues.
Nephrol Dial Transplant 2009; 24:3612–3617.
◆◆
Cohen RA, Bayliss G, Crispin JC et al. T cells and
in situ cryoglobulin deposition in the pathogenesis
of lupus nephritis. Clin Immunol 2008; 128:1–7.
◆◆
Weinracuh LA, Bayliss G, Gleason RE et al. A
pilot study to assess utility of changes in elements
of the Diabetes Impact management Scale in
evaluating diabetic patients for progressive
nephropathy. Metabolism 2009; 58:492–496.
Andrew Bostom, M.D.
◆◆
Bostom AG, Carpenter MA, Hunsicker L
et al. Baseline characteristics of participants
in the Folic Acid for Vascular Outcome
Reduction in Transplantation (FAVORIT)
trial. Am J Kidney Dis 2009; 53:121–128.
Rujun Gong, M.D., Ph.D.
◆◆
Gong R, Multitarget anti-inflammatory
action of hepatocyte growth factor, Curr
Op Invest Drugs 2008: 9:1163–1170.
◆◆
Gong R, Latif S, Morris DJ et al. C0localization of glucocorticoid metabolizing and
prostaglandin synthesizing enzymes in rat kidney
and liver, Life Sciences 83:725–731, 2008
◆◆
Gong R, Rifai A, Ge Y et al. Hepatocyte growth
factor suppresses pro-inflammatory NF-kB activation
through GSK3b inactivation in renal tubular
epithelial cells. J Biol Chemi 2008; 283:7401–7410.
Andrew Cohen, M.D.
◆◆
◆◆
◆◆
Anderson AH, Cohen AJ, Kutner N et al.
Missed dialysis sessions and hospitalization
in hemodialysis patients after Hurricane
Katrina. Kidney Int 2009; 75:1202–1208
Hyre AD, Cohen AJ, Kutner N et al, Psychosocial
status of hemodialysis patients one year after
Hurricane Katrina. Am J Med Sci 2008;336:94–98.
Hyre AD, Cohen AJ, Kutner N et al. Prevalence
and predictors of posttraumatic stress disorder
amont hemodialysis patients following Hurricane
Katrina. Am J Kidney Dis 2007; 50:585–593.
Susie L. Hu. M.D.
◆◆
Hu SL, Colvin G, Rifai A et al. Glomerulonephritis
after hematopoietic cell transplantation: IgA
nephropathy with increased excretion of galactosedeficient IgA-1. Nephrol Dial Transplant
◆◆
Naylor E, Hu SL, Robinson-Bostom L.
Nephrogenic systemic fibrosis with septal
panniculitis mimicking erythema nodosum,
J Am Acad Derm 2008: 58:149–150
◆◆
Brim N, Cu-Uvin S, Hu SL. Bone Disease
and Pathologic Fractures in a patient with
tenofovir induced Fanconi Syndrome.
AIDS Reader 2007; 17:322–323
Lance D. Dworkin, M.D.
◆◆
Gong R, Rifai A, Ge Y, Chen S, Dworkin
LD. Hepatocyte Growth Factor Suppresses
Proinflammatory NF{kappa}B Activation
through GSK3{beta} Inactivation in Renal
Tubular Epithelial Cells. J Biol Chem. Epub.
January, 2008. 283(12):7401–10, March, 2008
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Rifai A, Dworkin LD. IgA nephropathy: markers
of progression and clues to pathogenesis.
Kidney Int 73(12):1338-40, June 2008
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Dworkin LD, Cooper CJ. Renal Artery Stenosis.
NEJM 361(20):1972–1978. November, 2009
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J. Gary Abuelo, M.D.
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injury. Hosp Phys 2008; 44:21–24.
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Regnante R, O’Bell J, Gordon P. Renal artery
stenosis: clinical and therapeutic implications.
Med Health RI 2008; 91:304–308.
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Shougang Zhuang, M.D., Ph.D.
Shemin D, Briggs D, Greenan M. Complications of
therapeutic plasma exchange: a prospective study of
1727 procedures. J Clin Apher 2007; 22:270–276.
Angelito Yango, M.D.
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Yango A, Gohh RY, Wang LJ et al. The utility
of 6 month protocol biopsy under modern
immunosuppression. Clin Neph 2008: 70:490–495. l
cells. Am J Physiol Renal Physiol. 2007;292:F440–7
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Aboyage-Kumi M, Yango A, Gohh RY. Acute
disseminated encephalomyelitis in a renal transplant
patient. Transplant Proc 2007; 5:1751–1753.
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Zhuang S, Gilbert Rk, an Y et al. ERK activation
mediates mitochondria dysfunction and necrosis
induced by hydrogen peroxide in renal proximal
tubular cells. J Pharmacol Exp Ther 2008; 325:732–740
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Zhuang S, Kinsey GR, Rasbach K, Heaprin
binding epidermal growth factor and Src family
kinases in proliferation of renal epithelial cells. Am
J Physiol Reanl Physiol 2008; 294:F459–468
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Zhaung S, Lu B, Daubert R et al. Suramin
promotes recovery from renal ischemia/reperfusion
injury in mice. Kidney Int 2009; 75:304–311.
NEPHROLOGY FELLOWSHIP PROGRAM
J. Gary Abuelo, M.D., Program Director
John W. O’Bell, M.D., Associate Program Director
Departing Clinical Fellows
Name
Medical School
Residency
Career Plans
Ritche Chiu, M.D.
University of the Philippines
Eastern Virginia Medical
School
Clinical Practice, Ohio
Subil Go, M.D.
University of the Philippines
Cleveland Clinic Foundation, OH Clinical Practice, California
Premal Joshi, M.D.
University of Baroda, India
Wright State University, OH
Clinical Practice, Texas
Katherine Richman, M.D.
Brown Medical School, RI
Brown Medical School, RI
Assistant Professor, Division
of Kidney Disease and
Hypertension, Brown
University
Abha Saxena, M.D.
University of Alabama School
of Medicine, Birmingham, AL
Robert Wood Johnson
University, NJ
Clinical Practice, Iowa
Charles Stuart, M.D.
Albany Medical College
University of Minnesota
Clinical Practice, Wisconsin
Name
Medical School
Residency
Marilena Caldarusa, M.D.
Dartmouth Medical College
Alpert Medical School of Brown University
Wirasat Hasnain, M.D.
Dow Medical College,
Pakistan
State University of New York, Buffalo
Fuad Said, M.D.
University of Jordan
Alpert Medical School of Brown University
Saeed Shaffi, M.D.
Rawalpindi Medical College,
Pakistan
Creighton University
Current Clinical Fellows
Current Research Fellows
94
Name
Medical School Residency
Maoyin Pang, M.D., Ph.D.
Shanghai Medical School, Peoples Republic of China
Murugavel Ponnusamy, Ph.D
Annamala University, India
a c a d e m i c y e a r s 20 08 a n d 20 09
RESEARCH
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$296,391
$433,907
$60,072
$82,164
$357,003
$516,071
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$5,060,811
$3,125,915
$350,982
$252,898
$5,411,793
$3,378,803
S ELEC T ED
B A S IC RE S EARCH
S ELEC T ED
CLINICAL RE S EARCH
Rojun Gong, Ph.D.
Andrew Bostom, M.D.
◆◆
Renoprotective Effect of ACTH: Identification
of the Therapeutic Targets of ACTH in
Human Kidney, Questcor Pharmaceuticals
◆◆
Folic Acid for Vascular Outcome Reduction in
Transplantation (FAVORIT) Trial, National Institute
of Diabetes and Digestive and Kidney Diseases
◆◆
ACTH: A Novel Therapy to Slow or Prevent
Progressive Kidney Disease, Questcor Pharmaceuticals
◆◆
◆◆
Role of Glycogen Synthase Kinase 3B in
Pathogenesis of Inflammatory Kidney
Disease, Rhode Island Foundation
A Randomized Controlled Trial for
Homocysteine, National Institute of Diabetes
and Digestive and Kidney Diseases
Lance D. Dworkin, M.D.
◆◆
Zhuang Zhu
◆◆
Role of Heparin Binding Epidermal Growth Factor
in Renal Cell Proliferation, Brown University
Susie Hu, M.D.
◆◆
Impact of Subclinical Chronic Kidney Disease
and Progression on Cardiovascular Disease
Outcomes, Rhode Island Foundation
◆◆
Validation of Accurate Kidney Function
Measurement Using Iodixanol Elimination
During Routine Angiography for Assessment of
Cardiovascular Disease Risk Due to Subclinical
Chronic Kidney Disease, Brown University
Shougang Zhaung, M.D.
◆◆
Dedifferentiation Following Renal Cell
Injury, National Institute of Diabetes
and Digestive and Kidney Diseases
Cardiovascular Outcomes in Renal Artherosclerotic
Lesions (CORAL), National Institute of Health
95
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
Obst e t r i c &
c o n su ltat i v e
medicine
m i ss i o n
T
o provide expert care to women with medical
problems in pregnancy from obstetric internists,
gastroenterologists, and women’s behavioral
health specialists;
To provide internal medicine, primary care, and behavioral health services to the obstetric and gynecologic patients at Women & Infants Hospital and the community;
To support community based ob gyn practices to improve access and quality of care provided to all women;
To educate medical students, internal medicine and OB/
GYN residents, and Obstetric Medicine and Gastroenterology fellows to treat medical problems in pregnancy and
provide general medical and perioperative consultation;
To engage in research and curriculum development
in the medical and psychiatric care of pregnant and
postpartum women.
Overvie w
The unique expertise of the Women and Infants Hospital Division of Obstetric and Consultative Medicine
has continued to build its national and international
reputation as a leader in the care of medical problems
in pregnancy. Furthermore, the Department is pleased
to announce the new Academic Division of Obstetric
Medicine, making Brown University the first in the
United States with such a Division. This places our
department at the forefront of this field just as evidence
is emerging about the link between pregnancy outcomes
and risk for cardiovascular disease, diabetes and renal
disease. Obstetric Medicine has been a Division in the
Department of Medicine at Women and Infants Hospital for 16 years. During that time it has grown into a
multidisciplinary division with an international reputation that is thriving in all aspects of academic medicine.
The Center for Obstetric Medicine now offers a multidisciplinary, tumor-board style program specifically
for pregnant patients with medical problems. SCIPP
– or Specialty Care in Pregnancy Program is the only
program of its kind in the U.S., which features a weekly
conference that allows for on-site collaboration from
96
Karen Rosene-Montella, M.D., Professor of Medicine and OB/GYN,
Alpert Medical School of Brown University; Chief of Medicine,
Women & Infants Hospital
a team that includes obstetricians, obstetric internists,
maternal-fetal medicine specialists, obstetric anesthesiologists, labor/delivery/recovery nurses with critical
care expertise, as well as medical specialists with an
interest in caring for women in pregnancy. Each week,
the SCIPP conference will focus on a different medical
specialty with input from gastroenterologists, rheumatologists, cardiologists, pulmonologists, hematologists,
endocrinologists, and radiologists.
A new Bone Health Program with a Bone Density Unit
has opened at the Center for Women’s Medicine, under
the direction of Dr. Geetha Gopalakrishan, who shares
her time between WIH and the Hallett Center.
Karen Rosene-Montella was elected President of the
International Society of Obstetric Medicine (ISOM) and
the Division has developed a new web-based forum for
improving the care of medical illness in pregnancy for
the ISOM. Our faculty has been invited speakers at the
national meetings of the American College of Chest Physicians, the International Society of Obstetric Medicine,
the International Society for the Study of Hypertension
in Pregnancy, Society of Maternal-Fetal Medicine, the
Society of Obstetric Anesthesiologists and Perinatologists (SOAP), the North American Society of Obstetric
Medicine (NASOM), the North American Society for
Psychosocial Obstetrics and Gynecology (NASPOG),
the XIXth World Congress of the World Association for
a c a d e m i c y e a r s 20 08 a n d 20 09
Social Psychiatry (Prague, Czech Republic), the American Association for the Study of Liver Diseases, Digestive
Disease Week, Crohn’s & Colitis Foundation of America,
the Women’s Issues in Gastroenterology and Hepatology, the American College of Gastroenterology, the
Radiologic Society of North America and the American
Thoracic Society Meeting. We are pleased to announce
that Dr. Ghada Bourjeily has been selected the recipient
of the 2009 Women’s Health Award from the American
College of Physicians (ACCP) on June 24, 2009.
We are proud to announce that Lucia Larson, M.D. was
elected President and Margaret Miller, M.D. elected
Secretary/Treasurer of the North American Society of
Obstetric Medicine (NASOM) at the NASOM Annual
Meeting in Washington, DC; May 1–3, 2009.
Courtney Bilodeau, M.D. was the finalist for the Clinical Abstract Poster Competition titled, “Labor and
Delivery in Hermansky-Pudlak Syndrome,” American
College of Physicians Annual Meeting; May 16. 2008.
Dr. Bilodeau also received the 2009 Peter Garner Prize/
Young Investigator Award at the North American Society of Obstetric Medicine Annual Meeting, Renaissance
Marriott, Washington, DC, May 2–3, 2009. Her awardwinning presentation was entitled, “Asthma Severity
and Obesity in Pregnancy.”
Each year our fellowship graduates leave the program
and go on to establish new programs in obstetric
medicine at universities in North America and around
the world. 2007–2009 was not any different. We are
excited to announce that our seventeenth fellow graduate of June 2008, Meghan Hayes, M.D., and Courtney
Clark Bilodeau, M.D., our eighteenth fellow graduate
of June 2009, have both accepted a position in the Dept.
of Medicine at Women & Infants Hospital as obstetric medicine attendings. Kenneth Chen, M.D., our
nineteenth OB Med. Fellow joined the Department of
Medicine as of July 1, 2008, as a first-year Obstetric
Medicine fellow. Dr. Chen was an advanced endocrinology trainee at The Canberra Hospital in Australia, and
most recently worked in the Department of Obstetric
Medicine at the Royal Hospital for Women in Sydney,
Australia. On July 1, 2009, Simonette Soler, M.D. and
Srilakshmi Mitta, M.D. joined the Dept. of Medicine as
the twentieth and twenty-first obstetric medicine fellows.
We are proud to announce that the Women’s Digestive
Disorder Track within the Brown University affiliated
training program in Gastroenterology offers a three-year
accredited Training Program in Gastroenterology the
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
goal of which is to prepare Board-eligible internists for
a career in clinical or academic Gastroenterology. The
program fulfills all training standards as mandated by
the A.C.G.M.E., A.B.I.M., A.S.G.E., A.G.A., and
A.C.G. The atmosphere is scholarly, and provides wide
exposure to clinical gastroenterology and hepatology
and clinical, translational and basic scientific research.
Dr. Sumona Saha joined us in July of 2005 as the first
GI fellow and completed her three-year fellowship
on June 30, 2008. She received her M.D. degree from
Brown University Medical School and completed
her residency in Internal Medicine from Beth Israel
Deaconess Medical Center. She became a new member
of the Crohn’s and Colitis Foundation of America, in
November 2007, and chaired the Inaugural Meeting of
Crohn’s & Colitis Support Group for Women on January 9, 2008. She participated in the CDC/CCFA site
visit for Ocean State Crohn’s and Colitis Area Registry
on February 1, 2008. She completed an Advanced Inflammatory Bowel Disease rotation at the Mayo Clinic
Rochester, Minnesota, sponsored by the Crohn’s &
Colitis Foundation of America in May, 2008. She has
accepted a position as Assistant Professor of Medicine
at the University of Wisconsin-Madison Hospital in
Madison, Wisconsin. Dr. Saha will continue to collaborate with the Women & Infants’ GI Division on
inflammatory bowel disease in pregnancy projects. She
returned to Rhode Island in April, 2009, to present at
the CDC/CCFA site visit for the Ocean State Crohn’s
and Colitis Area Registry.
Amanda Pressman, M.D., joined the Department
of Medicine on July 1, 2008 as a first-year Gastroenterology fellow. She received her M.D. degree from
Case Western Reserve University School of Medicine
(CWRU), Cleveland, Ohio, and completed her residency in Internal Medicine from Beth Israel Deaconess
Medical Center, Boston Massachusetts. Dr. Pressman
recently worked as a staff physician at the Hebrew
Rehabilitation Center since July 2006.
Karen Rosene-Montella, M.D., Chief of Medicine, is
pleased to announce the addition of numerous new
faculty members.
Lilia Romero-Bosch, M.D., joined the Department of
Medicine as an attending psychiatrist in the Division of
Behavioral Health on July 7, 2008. Dr. Bosch received
her medical degree from the University of Medicine and
Dentistry of New Jersey, New Jersey Medical School
and completed her residency in General Pediatrics/
97
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
General Psychiatry/Child and Adolescent Psychiatry
from the Alpert Medical School of Brown University,
Rhode Island Hospital, Providence, RI.
Meghan Hayes, M.D., completed her Obstetric Medicine Fellowship with the Department of Medicine at
Women & Infants Hospital on June 30, 2008, and joins
us as of July 1, 2008, as an Obstetric Medicine attending
and Medical Director of Emergency Preparedness. She
received her M.D. degree from the State University of
New York Health Science Center at Syracuse College of
Medicine and completed her residency from the David
Grant USAF Medical Center affiliated with the University of California at Davis.
Courtney Clark Bilodeau, M.D., completed her Obstetric Medicine Fellowship with the Department of Medicine at Women & Infants Hospital on June 30, 2009,
and joins us as of July 1, 2009, as an Obstetric Medicine
attending physician. Dr. Bilodeau received a bachelor’s
degree cum laude in English from the University of
Rochester in Rochester, NY, and her medical degree
from the Chicago Medical School at Rosalind Franklin
University of Chicago, IL. She completed a residency in
internal medicine and a fellowship in obstetric medicine
at The Alpert Medical School of Brown University.
Nnenna Okpara, M.D. has joined the staff in the
Division of Women’s Digestive Disorders at Women &
Infants Hospital on July 1, 2009. Dr. Okpara received
a bachelor’s degree summa cum laude in biology from
the University of Houston in Houston, TX, and her
medical degree from the Columbia University College
of Physicians and Surgeons in New York. She completed
her residency in internal medicine at New York Presbyterian Hospital/Columbia University Medical Center
and a fellowship in gastroenterology at The Alpert
Medical School of Brown University.
Mariam Fayek, M.D., has joined the staff in the
Division of Women’s Digestive Disorders at Women
& Infants Hospital and will begin seeing patients in
August 2009 at the Center for Women’s Gastrointestinal
Services, part of Women & Infants Center for Women’s
Medicine. She received a bachelor’s degree cum laude in
biochemistry from New York University, and graduated
Alpha Omega Alpha, the medical honor society, from
the Howard University College of Medicine in Washington, DC.
Marisa VanPoznak, M.D., has joined the staff in the
Center for Women’s Primary Care, part of the Center
for Women’s Medicine at Women & Infants Hospital.
98
Dr. VanPoznak graduated from Cornell University,
where she was a member of the Dean’s List and also
received the Frederick G. Marcham Prize. She earned
her medical degree from Dartmouth Medical School
in Hanover, NH and completed her internal medicine
residency at The Alpert Medical School of Brown University.
Sara Wriston, NP, joined the Center for Women’s
Gastrointestinal Services in June 2008. She is a board
certified family nurse practitioner who received her
graduate degree from the University of Pennsylvania.
She has extensive experience in the fields of internal
medicine, obstetrics and gynecology, and oncology. Her
interests include liver disease, particularly hepatitis, and
gastrointestinal problems in pregnancy. She started a
pregnant/post partum, hepatitis patient database, tracking the patients treated at the Center.
In addition to the new members of our team, I am very
pleased to announce that Lucia Larson, M.D. has been
promoted to Director of the Division of Obstetric and
Consultative Medicine in the Department of Medicine at Women & Infants Hospital as of June 1, 2009.
Meghan Hayes, M.D., one of our newest attendings,
has been appointed to the Brown faculty as Assistant
Professor of Medicine (Clinical) as of May 1, 2009.
We are very proud to say that several of our doctors were
named “2009 Top Docs for Women by Rhode Island
Monthly” and they include Christy Dibble, D.O., Silvia
Degli Esposti, M.D. and Carmen Monzon, M.D..
Silvia Degli Esposti, M.D., Director of the Center for
Women’s Gastrointestinal Disorders, is very pleased to
announce that The Rhode Island Perinatal Hepatitis
Prevention Program, a collaborative effort of Women
& Infants Hospital (Center for Women’s Gastrointestinal Services), Hasbro Children’s Hospital, the VNA of
Care New England, and the Rhode Island Department
of Health, was recently recognized by the Centers for
Disease Control and Prevention. Rhode Island has the
highest immunization rate in the country – 95% for
three doses in the first eight months of life – of infants
born to women with hepatitis B, March, 2009.
The Center for Women’s Gastrointestinal Services at
Women & Infants started the first Ambulatory Patient
and Family Centered Care group in 2008. The Center
for Women’s Gastrointestinal Services took part in the
“Take Steps Walk for Crohn’s & Colitis”, Colt State Park,
Bristol, RI, on Saturday, June 13, 2009. The Center’s team
raised over $2,500.00 that will be used for future research.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Numerous physicians were interviewed by local and
national media and include:
regarding “Postpartum Depression: Signs and Symptoms”; March 23, 2009.
Karen Rosene-Montella, M.D. was interviewed by Dr.
Lisa Mazzullo, M.D., of Reach M.D. Radio regarding
the textbook Medical Care of the Pregnant Patient, 2nd
edition; July 10, 2008, and was interviewed by Barbara
Morse from Channel 10 regarding Thyroid in Pregnancy,
which aired on Channel 10 News; April 6, 2009.
The First Annual 5K Run and 2-Mile Walk “Stepping
Out of the Darkness” was held at Slater Memorial
Park, Pawtucket, RI. Proceeds benefited the Women
& Infants Hospital Day Program for the treatment of
Postpartum Depression; May 10, 2008.
Colleen Kelly, M.D. was interviewed by Dr. Lauren
Streicher for an XM radio show on “reachM.D.”, a
channel on XM Radio that has news/educational activities for physicians. Dr. Streicher hosts a show devoted
to women’s health issues and interviewed Dr. Kelly
about medical issues that pregnant women who have
had bariatric surgery face; October 24, 2008. She was
also interviewed again by XM radio broadcast for the
show “Advances in Women’s Health.” Hosted by Lauren
Streicher, M.D., the topic of discussion was “Bariatric
Surgery and a Baby on Board”; January 2009.
Margaret Miller, M.D. participated in an interview with
Kim Frankenthal, XM Radio. The topic of discussion
was Biomarkers for Preeclampsia; February 2009.
Lucia Larson, M.D. was interviewed by Marion Davis,
Contributing Healthcare Writer, for the Providence
Business News on May 21, 2009. Dr. Larson answered
questions about her clinic work, her research, and
efforts to expand the pool of doctors with expertise in
obstetric medicine. The interview/article was entitled
“Five Questions With: Dr. Lucia Larson”.
Silvia Degli-Esposti, M.D. was interviewed by Advance
for Nurses Magazine. The article “Keeping a Watchful
Eye,” which discusses the Perinatal Hepatitis Prevention Program earned the front cover. She was also
interviewed by R.I. Monthly for the “Best Doctors for
Women” issue; March 9, 2009.
Christy Dibble, D.O. interviewed with Barbara Morse
from Channel 10 regarding Women’s Gastrointestinal
Disorders and Management at Women & Infants
Hospital; June 2009.
Margaret Howard, Ph.D. interviewed with Kate Rope
for Cookie Magazine regarding “Postpartum Anxiety
Disorders;” May 15, 2009 and with Bonnie Rochman for Parenting Magazine regarding “Mother-Baby
Units for Postpartum Depression: A Comparison of 2
Models of Care;” May 27, 2009. Dr. Howard was also
interviewed by Marisa Cohen of Baby Talk Magazine
Christy Dibble, D.O. received a Certificate of Appreciation from the Rhode Island Cancer Council acknowledging her contribution of time and effort to enhance
and improve cancer awareness, control and education in
Rhode Island, September 2007. Dr. Dibble participated
in the Colorectal Cancer Education and Awareness
Program in conjunction with the American Cancer
Society as an educator in March, 2008. She chaired the
Community Colorectal Cancer Education and Awareness Effort with the American Cancer Society recognizing March as National Colorectal Cancer Awareness
Month. She was also the Chairperson of the Rhode
Island Colorectal Cancer Detection and Screening Work
Group, Rhode Island Department of Health, American
Cancer Society; March 2008. In conjunction with The
Partnership to Reduce Cancer in Rhode Island, Christy
Dibble, D.O. developed and presented Colorectal
Cancer Education and Awareness programs for Rhode
Island and Connecticut corporations and Senior Centers as part of Colorectal Cancer Month, March 2009.
Lucia Larson, M.D. & Niharika Mehta, M.D. facilitated a workshop entitled “Medical Care of the Pregnant
Woman for the Primary Care Provider;” at the Harvard
School of Public Health Primary Care Internal Medicine: Principles and Practice course, Cambridge, MA;
October 21, 2008.
The Department of Medicine had many
prestigious visitors and they include:
◆◆
Marc Rodger, M.D., FRCPC, MSc (Epidemiology), Head, Thrombosis Program, Deputy Director,
Senior Scientist, Clinical Epidemiology Program,
Ottawa Health Research Institute, Ottawa Hospital
visited with the Dept. of Medicine, March 4–
March 6, 2008. Dr. Rodger’s presented at WIH
Grand Rounds entitled “Thrombophilia in Pregnancy: Exploding Myths in Causality and Prevention.”
◆◆
Colleagues from the University of Calgary met
with several doctors in the Department of Medicine to discuss their plan to build a free-standing
women’s hospital; March 11, 2008.
99
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
◆◆
◆◆
Melissa Garrett from Duke University toured
and met with several people from the Center for
Women’s Gastrointestinal Disorders. She contacted
Dr. Silvia Degli Esposti to gain insight on the
day to day operations of our GI Division as they
are working on opening a similar center at Duke
University; May 8, 2008.
◆◆
Katherine Wisner, M.D., Professor of Psychiatry at
Western Psychiatric Institute and Clinic from the
University of Pittsburgh Medical Center visited the
Day Hospital with Drs. Howard and Pearlstein. She
presented a lecture entitled “Neonatal Effects of Depression and Anti-Depressant Use;” May 21, 2008.
◆◆
Margaret Howard, Ph.D. hosted two visitors from
Amherst, MA. Annette Cycon and Liz Friedman,
heads of a perinatal network, who are interested in
establishing a program similar to our Day Hospital at
one of the Western MA hospitals; October 19, 2007.
◆◆
Annette Cycon, LICSW, from Motherwoman
Inc. of Amherst, Massachusetts visited the Day
Hospital to discuss initiatives in establishing a Day
Hospital at their facility; May 9, 2008.
◆◆
Dr. Rebecca Lundquist and colleagues, Dr. Wendy
March and Dr. Robert Carey from the UMass
Medical Center visited the Day Hospital to discuss
initiatives in establishing a Day Hospital at their
facility; July 22, 2008.
◆◆
100
Directors from the Behavioral Health Department
at Forsyth Medical Center, North Carolina visited
the Post Partum Day Hospital to discuss initiatives
in establishing behavioral health services at their
facility; April 25, 2008. They met with Drs. Teri
Pearlstein and Margaret Howard.
Margi Clifford, MS, Perinatal Mood Disorders Coordinator from the Children’s Hospital in Anchorage, Alaska visited and toured the Day Hospital to
discuss initiatives in establishing a Day Hospital at
their facility; August 29, 2008.
◆◆
Karen Rosene-Montella, M.D., and Margaret Howard, Ph.D., visited the Baystate Medical Center in
Springfield, MA, to present the Day Hospital model
to the Pregnancy and Postpartum Support Coalition of Western Massachusetts on June 12, 2009.
◆◆
Dr. Raymond Powrie spent several days at the
University of Calgary from June 19–23 to provide
expertise in the development of a new academic
Women’s Hospital for Southern Alberta.
Many of our faculty contributed chapters
to the following textbooks:
◆◆
The textbook entitled Medical Care of the Pregnant
Patient, 2nd Edition, edited by Dr. Karen RoseneMontella was published by the American College
of Physicians in January, 2008. A review of the
textbook was published on June 5, 2008, in the
New England Journal of Medicine.
◆◆
Karen Rosene-Montella, M.D., was named Editorin-Chief of Obstetric Medicine: The Medicine
of Pregnancy. The first issue of the journal was
published in September, 2008.
◆◆
Christy Dibble, DO, authored Smart Brief, an
E-News brief for primary care practitioners distributed by the Rhode Island Department of Health
on “Tips for Ensuring Patient Compliance with
Colorectal Cancer Screening Recommendations;”
October 2008.
◆◆
The textbook entitled Pulmonary Problems in Pregnancy: Clinical and Research Aspects, edited by
Ghada Bourjeily, M.D. & Karen Rosene-Montella,
M.D., was published by Humana Press, a Part of
Springer Science+Business Media, in March, 2009.
◆◆
de Swiet’s Medical Disorders in Obstetric Practice,
5th Edition, is scheduled for publication by the
end of 2009. Raymond O. Powrie, M.D. is one of
the editors of the book.
F e l l o ws
◆◆
Courtney Clark Bilodeau, M.D.,
Teaching Fellow in Medicine (Obstetric Medicine)
◆◆
Kenneth Chen, M.D.,
Teaching Fellow in Medicine (Obstetric Medicine)
◆◆
Amanda Pressman, M.D.,
Teaching Fellow in Medicine (Gastroenterology)
◆◆
Sumona Saha, M.D.,
Teaching Fellow in Medicine (Gastroenterology
a c a d e m i c y e a r s 20 08 a n d 20 09
FAC U LT Y M E M B ER S
Full-Time Faculty
Professors
Karen Rosene-Montella, M.D.
Caron Zlotnick, Ph.D.
Courtney Bilodeau, M.D. (Ob Med Fellow)
Schol arly Activities
◆◆
Presented abstract titled, “Labor and Delivery in
Hermansky-Pudlak Syndrome” has been selected
by the Abstract Review Board for presentation
as a poster finalist and will be judged on-site at
Internal Medicine 2008 in Washington, DC. The
Clinical Vignette Poster Competition will take
place on Friday, May 16, 2008 in the Walter E.
Washington Convention Center; February 2008.
◆◆
Presented abstract entitled “Asthma Severity and
Obesity in Pregnancy” with Ghada Bourjeily,
M.D., Lucia Larson, M.D., and Christine Raker,
M.D., at the North American Society of Obstetric
Medicine Annual Meeting held at the Renaissance
Marriott in Washington, DC; May 2–3, 2009.
Clinical Faculty
Associate Professors
Silvia Degli Esposti, M.D.
Margaret Howard, Ph.D.
Assistant Professors
G. Thamara Davis, M.D.
Christy Dibble, D.O.
Ellen Flynn, M.D.
Meghan Hayes, M.D.
Neeta Jain, M.D.
Niharika Mehta, M.D.
Carmen Monzon, M.D.
Rossana Moura, M.D.
Iris Tong, M.D.
j u ly 1 , 20 07 – j u n e 30 , 20 09
Selected Honors
a n d s c h o l a r ly w o r k
Associate Professors
Lucia Larson, M.D.
Teri Pearlstein, M.D.
Raymond Powrie, M.D.
Assistant Professors
Ghada Bourjeily, M.D.
Margaret Miller, M.D.,
◆
Ghada Bourjeily, M.D.
Honors and awards
◆◆
Selected to serve as an executive member of the North
American Society of Obstetric Medicine, April, 2009.
◆◆
Received the Women’s Health Clinical
Research Award from the American College
of Chest Physicians (ACCP), June 2009.
◆◆
Selected to serve on the American College
of Physicians Women’s Health Network
Steering Committee, June, 2009.
Invited pr esentations
◆◆
Invited presenter: “Sleep and Sleep Disordered
Breathing in Pregnancy,” North American
Society of Obstetric Medicine (NASOM)
Scientific Forum, OMNI Shoreham Hotel,
Washington, DC, September 20, 2008.
◆◆
Invited presenter: “Diagnosis of VTE in Pregnancy,”
American College of Chest Physicians Annual
Meeting, Philadelphia, PA; October 28, 2008.
Schol arly Activities
Dr. Iris Tong
◆◆
Abstract entitled “Effect of In-Utero Exposure to
Iodinated Contrast Media on Neonatal Thyroid
Function” at the Lawson Wilkins Pediatric Endocrine
Society/European Society for Pediatric Endocrinology
meeting held in New York, NY. June, 2009.
◆◆
Abstract entitled “Epworth Sleepiness Scale Scores
in Pregnancy” has been accepted for presentation at
the 2008 American Thoracic Society International
Conference in Toronto, Ontario, Canada; January 2008.
101
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
◆◆
Presented abstract entitled “MultidetectorRow Computed Tomography in the Detection
of Pulmonary Embolism in Pregnancy” at
the American College of Chest Physicians’
Meeting, Chicago, IL; October 20–25, 2007.
◆◆
Presented abstract entitled “Symptoms of SleepDisordered Breathing, BMI, and Pregnancy Outcomes”
at the American College of Chest Physicians’
Meeting, Chicago, IL; October 20–25, 2007.
◆◆
Grants received from the Perkins Charitable
Foundation for the study of “Sleep disordered
breathing in pregnancy”. $84,500 in September 2008
and $66,000 in September 2007.
Silvia Degli-Esposti, M.D.
Honors and awards
◆◆
Member, American College of
Gastroenterology (ACG), June 2007.
◆◆
Member, Crohn’s and Colitis Foundation
of America (CCFA), November, 2007.
Meghan Hayes, M.D.
Schol arly Activities
◆◆
Presented an abstract entitled “Iliac Vein Compression
During Twin Gestation: A Case Report;” Hayes,
M, Bourjeily G, Woodfield C, Larson L, at the
International Society of Obstetric Medicine (ISOM)
Meeting held at the OMNI Shoreham Hotel
in Washington, DC, September 21–22, 2008.
◆◆
Trial IRB approved, “Magnesium Sulfate
vs Metoclopramide for Headache in
Pregnant Women; February 2008.
Margaret Howard, Ph.D.
Honors and awards
◆◆
Invited pr esentations
◆◆
Keynote speaker: “U.S. Based Mother-Baby Day
Hospitals: Why Can’t There Be More?” 22nd
Annual Conference of Postpartum Support
International, Houston, Texas; June 4–7, 2008.
◆◆
Keynote speaker: “Comprehensive Community
Treatment Model for Postpartum Depression:
What Works, What Doesn’t,” Annual
Meeting of the Southern New Jersey Perinatal
Cooperative, Princeton, NJ; October 10, 2008.
◆◆
Invited Presenter: “The Women & Infants Day
Hospital Model: Marketable in America?”, 35th
Annual Meeting of the North American Society
for Psychosocial Obstetrics and Gynecology
(NASPOG), New Haven, CT; February 4–7, 2009.
Schol arly Activities
◆◆
Abstract presentation: “Salvage Infliximab for
Crohn’s Disease in Pregnancy”, presented in
collaboration with Sumona Saha, M.D., at the
International Society of Obstetric Medicine Meeting
(ISOM), Philadelphia, PA; September 21, 2008.
◆◆
Presented a poster entitled “GI Consultations
in Pregnancy” Poster Presentation Session:
Outcomes Research, Epidemiology, and Quality
of Life at Digestive Disease Week (DDW) along
with Sumona Saha, M.D., Joseph Manlolo,
M.D., Christopher McGowan, M.D., Steven
Reinert, MS, Chicago, IL; June 3, 2009.
Schol arly Activities
◆◆
Participant: IPT/Sertraline Grant Research
Conference Calls and Meetings with the
University of Iowa; September 2007.
◆◆
Co-Investigator: “Placebo-Controlled Trial of
Sertraline and Interpersonal Psychotherapy for
Postpartum Depression”.
Study Number: R01 MH074919
IRB Project Number: 07-0047
Christy Dibble, D.O.
Invited pr esentations
◆◆
Appointed to the education project co-sponsored
by the American Cancer Society and CDC (as
part of the RI Comprehensive Cancer Control
Plan) for primary care providers regarding CRC
screening, detection and treatment. Dr. Dibble
will give a series of 2 hour lectures, August 2008.
Schol arly Activities
◆◆
102
Collaborating with the Rhode Island State
Comprehensive Cancer Partnership on a 6-month
project to design a plan to implement Cancer
Prevention and Treatment Programs statewide
under a federal grant. November 2007.
Reviewer, Archives of Women’s
Mental Health, March 2009.
December, 2007.
◆◆
◆◆
Presented an abstract entitled “The First 12
Months: Enhancing the Role of Pediatricians
in Identifying Postpartum Depression” at
the Postpartum Support International (PSI)
conference, Houston, TX, December 2007.
Presented an abstract and paper presentation entitled
“Neonatal Death as a Result of Maternal Suicide
Attempt;” Howard M, Miller M, Jain N, Bourjeily
G, at the International Society of Obstetric Medicine
(ISOM) Meeting held at the OMNI Shoreham
Hotel in Washington, DC, September 21–22, 2008.
a c a d e m i c y e a r s 20 08 a n d 20 09
David Kerstetter, M.D. (GI Fellow)
◆◆
Presented abstract entitled “Imaging of Crohn’s
Disease in the Era of Radiation Safety: Experience
with 100 Consecutive MR Enterography Exams”
at the American College of Gastroenterology
Meeting, Orlando, Florida; October 6, 2008.
Lucia Larson, M.D.
President-Elect, North American Society of
Obstetric Medicine (NASOM), NASOM Annual
Meeting, Washington, DC; May 1–3, 2009.
◆◆
Miller M, Howard M, Bourjeily G. Neonatal Death
as a Result of Maternal Suicide Attempt. Oral
presentation at the International Society of Medicine
Annual Meeting, Washington, DC, September, 2008.
◆◆
IRB submissions approved: -Awareness of
cardiovascular disease in Ob/Gyn patients.
◆◆
-Prevalence of chronic health problems in
mothers of very low birthweight infants.
◆◆
Pivotal PE Procurement – A multi-site
international trial that will attempt to identify
Serum biomarkers that may be predictive of
preeclampsia. Protocol No: PE-2-08-D. Beckman
Coulter, Inc., $475,000, October 1, 2008–
October 1, 2010. Co-Principal Investigator.
Schol arly Activities
◆◆
◆◆
Presented abstract entitled “Iliac Vein Compression
During Twin Gestation: A Case Report;” Hayes,
M, Bourjeily G, Woodfield C, Larson L, at the
International Society of Obstetric Medicine (ISOM)
Meeting held at the OMNI Shoreham Hotel
in Washington, DC, September 21–22, 2008.
Presented abstract entitled “Asthma Severity and
Obesity in Pregnancy” with Courtney Bilodeau,
M.D., Ghada Bourjeily, M.D., and Christine Raker,
M.D., at the North American Society of Obstetric
Medicine Annual Meeting held at the Renaissance
Marriott in Washington, DC; May 2–3, 2009.
Niharika Mehta, M.D.
Rossana Moura, M.D.
Schol arly Activities
◆◆
Workshop facilitator: “Medical Care of the
Pregnant Woman for the Primary Care Provider”,
Harvard School of Public Health Primary Care
Internal Medicine: Principles and Practice
course, Cambridge, MA; October 21, 2008.
Honors and awards
◆◆
◆◆
Secretary/Treasurer-Elect, North American Society
of Obstetric Medicine (NASOM), NASOM Annual
Meeting, Washington, DC; May 1–3, 2009.
◆◆
Presented “Premenstrual Dysphoric Disorder:
Hormonal and Nonhormonal Treatment Strategies,”
Mood Disturbance in Younger and Midlife Women:
Defining Treatment Strategies, at the symposium
faculty, 161st Annual Meeting of the American
Psychiatric Association, Washington, DC; May 4, 2008.
◆◆
Faculty presenter at Psychiatry Grand Rounds.
“Premenstrual Dysphoric Disorder,” Mount Sinai
School of Medicine, New York, NY; October 28, 2008.
◆◆
Invited presenter: “Premenstrual Dysphoric
Disorder: Treatment Strategies,” 14th Annual
Psychopharmacology Update, University of Nevada
School of Medicine and Nevada Psychiatric
Association, Las Vegas, NV; February 13, 2009.
◆◆
Presented “Effects of Depression, Anxiety
and Treatment on the Perinatal Woman,”
Symposium Chair and Faculty Presenter, 3rd
International Congress on Women’s Mental
Health, Melbourne Australia; March 18, 2008.
◆◆
Keynote Presentation: “Premenstrual Dysphoric
Disorder: Diagnosis and Treatment Options,” 3rd
International Congress on Women’s Mental
Health, Melbourne Australia; March 20, 2008.
Invited pr esentations
◆◆
Invited presenter: “Medical Illness in Pregnancy
for the Primary Care Provider,” Harvard Medical
School, Primary Care Internal Medicine: Principles
& Practice, Cambridge, MA, October, 2007.
◆◆
Presented Grand Rounds, “Common
Medical Problems in Pregnancy,” Greenville
Hospital, Greenville, SC; April 11, 2008.
◆◆
Invited presenter: “Caring for Medical Illness in
Pregnancy: Ten Things Every Clinician Should
Know.” American College of Physicians, Internal
Medicine 2009, Philadelphia, PA; April 25, 2009.
Elected President of the North American Society
for Psychosocial Obstetrics & Gynecology
(NASPOG) for 2009–2011, February 2009.
Invited pr esentations
Margaret Miller, M.D.
Honors and awards
Presented a clinical vignete/poster entitled
“Domperidone in Hyperemesis Gravidarum” at
the American College of Gastroenterology Annual
Meeting in Philadelphia, PA; October 16, 2007.
Teri Pearlstein, M.D.
Invited pr esentations
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Schol arly Activities
Honors and awards
◆◆
◆
103
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
◆◆
Presented “Non-Medical and Psychological
Interventions,” at the Inaugural Meeting of
the International Society for the Study of
Premenstrual Disorders, satellite course at the
7th Royal College of Obstetrics and Gynecology
International Scientific Meeting, Montreal,
Quebec, Canada; September 16–17, 2008.
◆◆
Invited presentation “Caring for Medical Illness
in Pregnancy: Ten Things Every Clinician Should
Know.” Powrie, RO, Larson, L, and Miller, M.
American College of Physicians, Internal Medicine
2009, Philadelphia, PA; April 25, 2009.
◆◆
Invited presentation entitled “Designing Safer
Systems for In-Hospital Care of Pregnant
Women with Medical Problems: The Role of
Obstetric Medicine (and Obstetric Anesthesia)
in the Era of Quality and Safety” at the 2009
North American Society of Obstetric Medicine
Annual Meeting held at the Renaissance
Marriott; Washington, DC; May 2–3, 2009.
◆◆
Invited Presentation at the Medical Complications
in Pregnancy Conference at the Royal College of
Physicians, London, UK. “Asthma, Pneumonia, &
Other Respiratory Problems;” October 5, 2007.
◆◆
Invited presentation: “Gastroenterology Disorders
in Pregnancy Workshop” at the Medical
Complications in Pregnancy Conference organized
by the Imperial College of London at the Royal
College of London, UK; November 12, 2008.
◆◆
Invited presentation: “Sepsis in pregnancy” at the
SOMANZ/ADIPS Combined Annual Scientific
Meeting, Adelaide, South Australia; November 1, 2008.
Schol arly Activities
◆◆
Participant: IPT/Sertraline Grant Research
Conference Calls and Meetings with the University
of Iowa; September 2007.
Grant award received 9/14/07:
R01 MH074919-01A2
Date of project: 9/14/07–5/31/12
NIMH, Annual Direct Cost $278,000
◆◆
Placebo-Controlled Trial of Sertraline and
Interpersonal Psychotherapy for Postpartum
Depression. The major goal of this two-site
project is to compare sertraline and interpersonal
psychotherapy to placebo in women with
postpartum depression in terms of efficacy on
depressive symptoms, anxiety and social functioning.
Principal Investigator: Caron Zlotnick,Ph.D. CoPrincipal Investigator: Teri Pearlstein, M.D.
Raymond Powrie, M.D.
Honors and awards
◆◆
Coordinating Editor, de Swiet’s Medical
Disorders in Obstetric Practice, 5th
Edition, Blackwell Publishing, 2006.
Invited pr esentations
◆◆
◆◆
104
Invited presenter: “Pulmonary Edema in the
Obstetric Patient,” Advances in Physiology and
Pharmacology in Anesthesia and Critical Care,
sponsored by the Department of Anesthesiology,
Wake Forest University School of Medicine,
Hilton Head, SC, October 30, 2007.
Presented “Pulmonary Edema in Pregnancy: Ten
Lessons I’ve Learned. Invited presentation Grand
Rounds, Tulane University Health Sciences Center,
School of Medicine, Department of Obstetrics
and Gynecology, New Orleans, LA; May 9, 2008.
◆◆
Invited presentation entitled “Approach to
Intrapartum Medical Emergencies” at Boston Medical
Center, Grand Rounds, Department of Obstetrics
and Gynecology, Boston, MA; January 21, 2009.
◆◆
Invited Presentation entitled “What’s New in
Obstetric Medicine? Where is the Pendulum
Swinging?” at Grand Rounds at the Department
of Anesthesia, Brigham and Women’s
Hospital, Boston, MA; February 18, 2009.
Karen Rosene-Montella, M.D.
Honors and awards
◆◆
Editor-in-Chief, Obstetric Medicine: The
Medicine of Pregnancy, 2008.
◆◆
Steering Committee Member, Office of Research on
Women’s Health and the National Institutes of Health,
“Moving into the Future – New Dimensions and
Strategies for Women’s Health Research for the NIH”;
Brown University and Women & Infants’ Hospital
is one of four sites nationally, March, 2009–present.
◆◆
Editor, Medical Care of the Pregnant Patient, 2nd
Edition, American College of Physicians, 2006–2009
◆◆
Editor, Pulmonary Problems in
Pregnancy: Clinical and Research Aspects,
Humana Press, Inc., 2006–2009.
Invited pr esentations
◆◆
Invited Speaker. Presented Grand Rounds,
“Venous Thromboembolism and Thrombophilias
in Pregnancy”, Prentice Women’s Hospital,
Northwestern University, Feinberg School of
Medicine, Chicago, IL, Friday, April 18, 2008
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
◆◆
Presented: “Maternal Mortality in the Developing
World: A Plan for Action”, International
Society of Obstetric Medicine (ISOM)
Meeting held at the OMNI Shoreham Hotel,
Washington, DC; September 21, 2008.
Presented at the American College of Chest
Physicians conference, “Venous Thromboembolism
and Pulmonary Vascular Complications in
Pregnancy - Treatment of Venous Thromboembolism
During Pregnancy,” Pennsylvania Convention
Center, Philadelphia, PA; October 28, 2008.
◆◆
Presented at Society of Maternal Fetal Medicine
(SMFM), “Medical Disorders of Pregnancy”,
Scientific Forum, San Diego, CA; January 28, 2009.
◆◆
Visting Professor, University of Toronto: Gave
Interhospital Grand Rounds at Women’s
College Hospital, Toronto, Canada, “Venous
Thromboembolism in Pregnancy,” November 16, 2007,
and Keynote Case Presentation, “Pregnancy and a
Prior Thrombosis,” Medical Disorders in Pregnancy
Post Graduate Course, Victoria College, University
of Toronto, Toronto, Canada, November 17, 2007.
Schol arly Activities
◆◆
Grant: Principal Investigator: James Haddow,
M.D.; Co-investigator: Karen RoseneMontella, M.D. awarded $1.3 million for a 3
year grant entitled “Maternal Hypothyroidism”
from the CDC; September 2007.
◆◆
Grant: Principal Investigator: Karen RoseneMontella, M.D.
Co-Investigator: Margaret Miller, M.D.
Date of Project: October 1, 2008 – October 1, 2010
Funded By: Beckman Coulter, Inc.
Estimated Project Funding: $475,000
Name of Project: Pivotal PE Procurement Protocol
#PE-2-08-D
Description of Project: This multi-site,
international trial will attempt to identify
serum biomarkers that may be predictive of
preeclampsia. A total of 1500 pregnant women,
week 20-36 gestation will be identified and
offered enrollment. These women will be followed
prospectively and blood, clinical information,
and delivery/birth outcome information
collected. This is a 2 year funded study and
W&I’s was chosen as the New England site.
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Sumona Saha, M.D. (GI Fellow)
Schol arly Activities
◆◆
Presented a poster at the Digestive Disease Week
2008 (DDW) meeting: McGowan C., Saha S., Chu
G., Resnick M., Moss SF: “Intestinal Ischemia
Due to Sodium Polystyrene Sulfonate (Kayexalate)
in Sorbitol: Not Just in the Very Ill”, Digestive
Disease Week 2008 (DDW); May 18, 2008.
◆◆
Abstract presentation: Saha S, Degli Esposti
S. “Salvage Infliximab for Crohn’s Disease in
Pregnancy”, International Society of Obstetric
Medicine (ISOM), September 21, 2008.
Iris Tong, M.D.
Honors and awards
◆◆
Section Editor, Ferri’s Clinical Advisor Instant
Diagnosis and Treatment: 5-Minute Consult Clinical
Comparion to Women’s Health, Philadelphia, PA,
Elsevier Moby; 2008 Edition; September, 2007.
Jeffrey Zaidman, M.D. (GI Fellow)
Schol arly Activities
◆◆
Presented oral abstract entitled “A Case of
Gastric Obstruction in a Pregnant Patient: a
Lap-Band Complication” at the International
Society of Obstetric Medicine Meeting (ISOM),
Washington, DC; September 21, 2008.
Caron Zlotnick, Ph.D.
Invited pr esentations
◆◆
Invited Speaker. Grand Rounds, “Interventions with
Pregnant Women with Partner Abuse,” University of
Rochester, Department of Psychiatry; April 30, 2008.
Schol arly Activities
◆◆
Participant: IPT/Sertraline Grant Research
Conference Calls and Meetings with the University of
Iowa; September 2007.
Grant Funded: Grant award received 9/14/07:
R01 MH074919-01A2
Date of project: 9/14/07–5/31/12
NIMH, Annual Direct Cost $278,000
Placebo-Controlled Trial of Sertraline and
Interpersonal Psychotherapy for Postpartum
Depression. The major goal of this two-site
project is to compare sertraline and interpersonal
psychotherapy to placebo in women with
postpartum depression in terms of efficacy on
depressive symptoms, anxiety and social functioning.
Principal Investigator: Caron Zlotnick,Ph.D.
Co-Principal Investigator: Teri Pearlstein, M.D.
105
o b s t e t r i c a n d c o n s u lta t i v e m e d i c i n e
OBSTETRIC AND CONSULTATIVE MEDICINE FELLOWSHIP PROGRAM
Departing Fellows
Name
Medical School
Residency
Career Plans
Meghan Hayes, M.D.
State University New York
Health Science Center at
Syracuse College of Medicine
David Grant USAF Medical
Center; Travis Air Force Base,
California. In affiliation with
University of California at
Davis Medical School
June 2008 graduate.
She accepted a position
in the Dept. of Medicine at
Women & Infants Hospital as
an OB Medicine attending.
Name
Medical School
Residency
Career Plan
Courtney Bilodeau, M.D.
Rosalind Franklin University
Chicago Medical School
Chicago, IL
Internal Medicine Residency
Alpert School of Medicine of
Brown University
Providence, RI
June 2009 graduate. She
will be joining the Dept. of
Medicine at Women & Infants
Hospital as an OB Medicine
attending as of July 1, 2009.
Kenneth Chen, M.D.
The University of Sydney
Sydney, Australia
General Internal Medicine
Westmead Hospital
Sydney, New South Wales,
Advanced Endocrinology
Trainee, The Canberra
Hospital, Canberra, ACT,
Australia
June 2009 graduate.
Name
Medical School
Residency
Career Plan
Sumona Saha, M.D.
Brown-Dartmouth Medical
Program, Dartmouth Medical
School, Hanover, NH Brown
Medical School, Providence, RI
Beth Israel Deaconess
Medical Center
Boston, MA
June 2008 graduate.
Currently working at the
University of WisconsinMadison Hospital as an
attending gastroenterologist.
Name
Medical School
Residency
Career Plan
Amanda Pressman, M.D.
Case Western Reserve
University School of Medicine
(CWRU)
Cleveland, OH
Internal Medicine
Beth Israel Deaconess
Medical Center
Boston, MA
June 2011 graduate.
Current Fellows
Departed Fellows
Current Fellow
106
a c a d e m i c y e a r s 20 08 a n d 20 09
S e l e c t e d Pub l i c at i o n s
◆◆
Bourjeily G, Khalil H, Miller M, O’Connor K,
Rosene-Montella K. Pregnancy and delivery in
a patient with hypoplastic lung and dyspnea. J
Obstet Gynaecol. 2008 Feb; 28(2): 228–9.
◆◆
Bourjeily G, Miller M. Obstetric disorders in the
ICU. Clin Chest Med. 2009 Mar;30(1):89–102.
◆◆
Hayes, M, Bourjeily G, Woodfield C,
Larson, L. Iliac vein compression during twin
gestation: a case report. Obstetric Medicine:
The Medicine of Pregnancy. 2008 Sept;1:30.
◆◆
Hayes ME, Bourjeily G, Rosene-Montella K.
Venous thromboembolic disease and pregnancy.
N Engl J Med. 2009 Feb 5;360(6)639.
◆◆
Strawbridge, EM, Howard M, Nolan P, Feller
E. Increasing post-partum depression detection
in Rhode Island: targeting pediatric providers.
Med Health R.I. 2008 Aug;91(8):255–7.
◆◆
◆◆
◆◆
◆◆
Howard M, Miller M, Jain N, Bourjeily G. Neonatal
death as a result of maternal suicide attempt. Obstetric
Medicine: The Medicine of Pregnancy. 2008 Sept;1:30.
Larson L, Miller M, Mehta N. Letter to the
editor: Venous thromboembolic disease and
pregnancy. N Engl J Med. 2009 Feb 5;360(6):638.
Miller M, Bourjeily G. Managing the
critically ill pregnant patient. Pulmonary
and Critical Care Update. American College
of Chest Physicians. 2009 Apr;23, lesson 8.
Pearlstein T, Steiner M. Premenstrual dysphoric
disorder: burden of illness and treatment update.
J Psychiatry Neurosci. 2008 Jul;33(4):291–301.
◆◆
Pearlstein T. Perinatal depression: treatment
options and dilemmas. J Psychiatry
Neurosci. 2008 Jul;33(4):302–18.
◆◆
Pearlstein T. Overview of eating disorders.
TheForum: A Working Group for Women’s
Healthcare. 2008 Aug;6(4):4–7.
◆◆
Pearlstein T, Howard M, Salisbury A,
Zlotnick C. Postpartum depression. Am J
Obstet Gynecol. 2009 Apr;200(4):357–64.
◆◆
Sauve N, Powrie RO, Larson L, Phipps M, Weitzen
S, Fitzpatrick D, Rosene-Montella K. The impact of
an educational pamphlet on knowledge and anxiety
in women with preeclampsia. Obstetric Medicine:
The Medicine of Pregnancy. 2008 Sept;1(1):11–17.
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
Powrie RO. A 30-year-old woman with
chronic hypertension trying to conceive.
JAMA, 2007 Oct 3; 298(13):1548–58.
◆◆
Sia WW, Powrie RO, Cooper AB, Larson
L, Phipps M, Spencer D, Suave N, RoseneMontella K. The incidence of deep vein
thrombosis in women undergoing cesarean
delivery. Thromb Res. 2009;123(3):550–5.
◆◆
Gibson PS, Powrie RO. Anticoagulants
in pregnancy: when are they safe? Cleve
Clin J Med. 2009 Feb;76(2):113–27.
◆◆
Rodger MA, Paidas M, McLintock C, Middeldorp
S, Kahn S, Martinelli I, Hague W, RoseneMontella K, Greer I. Inherited thrombophilia
and pregnancy complications revisited.
Obstet Gynecol. 2008 Aug;112:320–324.
◆◆
Lowe S, Nelson-Piercy C, Rosene-Montella
K. Welcome to Obstetric Medicine: The
Medicine of Pregnancy. Obstetric Medicine: The
Medicine of Pregnancy. 2008 Sept;1(1):1.
◆◆
Lowe S, Nelson-Piercy C, Rosene-Montella K. The
role of obstetric medicine in holistic care. Obstetric
Medicine: The Medicine of Pregnancy. 2009 Mar;2(1):1.
◆◆
Lowe S, Nelson-Piercy C, Rosene-Montella K. First
issue of Obstetric Medicine. Obstetric Medicine:
The Medicine of Pregnancy; 2(1):44; March, 2009.
◆◆
Lowe S, Nelson-Piercy C, Rosene-Montella
K. Editorial, Obstetric Medicine: Bridging
the Gap; Obstetric Medicine: The Medicine
of Pregnancy; June, 2009; 2(2):45.
◆◆
Tong I. The treatment of menopausal hot
flashes. Med Health R.I. 2008 Mar;91(3):73–6.
◆◆
Tong IL, Powrie RO. Contraception for
women with medical disorders. Internal
Medicine Solutions. 2008 Oct;1(2):1–16.
◆◆
Zaidman J, Kozloff M, Moura R. A case of
gastric obstruction in a pregnant patient: a lapband complication. Obstetric Medicine: The
Medicine of Pregnancy. 2008 Sept;1(1):11–17.
◆◆
Johnson DM, Zlotnick, C. Utilization of
mental health treatment and other services
by battered women in shelters. Psychiatr
Serv. 2007 Dec;58(12):1595–7.
◆◆
Battle CL, Zlotnick C, Pearlstein T, Miller
IW, Howard M, Salisbury AL, Stroud L.
Depression and breastfeeding: which postpartum
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Depress Anxiety. 2008;25(10):888–91.
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P U L M ONARY,
CRI T ICAL CARE &
S LEEP M EDICINE
OVERVIE W
The Division has been expanding its
activities in the following areas:
1.
2.
3.
4.
Vascular Physiology/Pulmonary Hypertension
Critical Care and Knowledge Transfer
Sleep Medicine
Interventional Pulmonology
Vascular Physiology/Pulmonary Hypertension:
Our Pulmonary Hypertension program continues to
be recognized nationally, under the leadership of James
Klinger M.D., Associate Professor of Medicine. Dr.
Klinger has developed recognized expertise in taking
and treating patients with secondary pulmonary hypertension, associated with collagen vascular diseases and
chronic obstructive pulmonary disorders. The clinical
service remains on the cutting edge of new treatment
protocols for pulmonary hypertension and is involved,
under the leadership of Dr. Klinger, in multiple clinical
trials evaluating new agents for the treatment of pulmonary hypertension. These clinical activities in pulmonary
hypertension complement the nationally-recognized regional activities of several Division members at the Veterans Administration Medical Center in the pulmonary
vascular biology laboratories of several Division members. Several have NIH-funded research in this area,
including Sharon Rounds M.D., Professor of Medicine,
Dr. James Klinger, Associate Professor of Medicine, Dr.
Elizabeth Harrington, Associate Professor of Medicine,
and Dr. Qing Lu, Assistant Professor of Medicine. The
laboratory investigates questions regarding endothelial
barrier function, apoptosis and lung injury, and the role
of naturetic peptides on pulmonary microvascular function. It has been a great research training ground for
several of our pulmonary and critical care fellows.
Critical Care and Knowledge Transfer:
Critical care is a major function of the research division,
along with training activities. Under the leadership of
Mitchell Levy M.D., Professor of Medicine and Director of Critical Care at both Rhode Island Hospital and
The Miriam Hospital, the program has continued to
expand. In July 2006, the Division of Critical Care at
The Miriam Hospital was merged with the Rhode Island
Hospital Division. Since that time, our Division has
welcomed three new faculty members from The Miriam
Hospital into our Division. These include the following:
108
Mitchell Levy, M.D., Professor of Medicine
Interim Director, Division of Pulmonary, Critical Care & Sleep Medicine
Gerardo Carino M.D., Director of The Miriam Hospital Intensive Care Unit, who completed his fellowship
here at Brown University; Jeffrey Mazer M.D. who
completed his fellowship here at Brown and then was
asked to join the faculty; and Jigme Sethi M.D. who
was recruited to Brown from the University of Pittsburgh where his major research interest was in studying
the biology of exhaled oxides as biomarkers of pulmonary inflammation in asthma and lung transplantation.
Dr. Levy’s prominence in the field of critical care medicine continues to grow, both nationally and internationally. He served as President of the Society of Critical
Care Medicine in 2009. The major focus of research for
Dr. Levy and the MICU has been knowledge transfer and health services research in the fields of sepsis
and end-of-life care. Dr. Levy recently completed and
published the results of Phase III of the Surviving Sepsis
Campaign, a study evaluating the use of performance
matrix to change clinical practice and improve survival.
The results of this study included 15,000 patients. Both
the RIH Medical Intensive Care Unit and The Miriam
Hospital Medical Intensive Care Units are leaders in
the field of end-of-life care and will guide an upcoming
statewide collaborative in palliative care and communication in the ICU. In addition, the MICU at Rhode
Island Hospital provides direction and clinical support
to the Respiratory Intermediate Care Unit and stepdown ICUs at RIH, as well as the medical intensive care
units at the Veterans Administration Medical Center,
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
The Miriam Hospital, and Memorial Hospital of Rhode
Island. These units have been an outstanding clinical
and research training site for the pulmonary critical care
fellows, as well as internal medicine residents.
Ph.D. and Mariam Louis M.D., both of whom are
working towards expanding the Sleep Center research
commitment through NIH and other grant applications.
Ongoing areas of research include:
The Department of Interventional Pulmonology has
continued to flourish under the direction of Muhanned
Abu-Hijleh M.D., Assistant Professor of Medicine. Assisted by Kevin Dushay M.D., this program serves as
the major reference point for interventional pulmonology for southern New England, incorporating all the
latest techniques in interventional pulmonology. Dr.
Abu-Hijleh has continued his research efforts in multicenter clinical trials and is completing his work on a
trial to evaluate the safety and effectiveness of endobronchial valves for the treatment of severe obstructive lung
disease. Both Drs. Abu-Hijleh and Dr. Dushay continue
their work with medical thoroscopy and advances in
bronchoscopic techniques for lung cancer. They continue to collaborate with the Rhode Island Hospital Cancer
Center in producing the most up-to-date, state-of-theart treatment for patients from southern New England.
1. improving the quality of end-of-life care in
the medical intensive care unit
2. knowledge translation and performance
matrix in sepsis
3. biomarkers in sepsis
4. HF oscillation in ARDS
5. Evaluation of microcirculatory abnormalities
in sepsis and trauma patients
We are a clinical coordinating center for multi-center,
randomized, controlled trials for new agents in sepsis and
currently have two Phase II and two Phase trials in process.
Sleep Medicine
Our Sleep Program has continued to expand. We have
responsibility for the medical direction of several sleep
laboratories around the state, including a laboratory
in Newport, West Warwick and East Providence. Drs.
Richard Millman, Professor of Medicine, and Alice
Bonitati, Clinical Associate Professor of Medicine,
our leading consultants in sleep medicine, have been
recognized in the community for their clinical excellence
and unique expertise in sleep disordered breathing and
non-respiratory sleep disorders. We have been fortunate
to recruit a nurse practitioner with expertise in sleep
medicine. Lauren Cushing, NP had formal sleep training
at the Massachusetts General Hospital. She has a busy
sleep practice in our Middletown and West Warwick
offices. We have had a successful collaborative effort with
the Department of Pediatrics to expand our expertise
in pediatric sleep medicine. Dr. Judy Owens from the
Department of Pediatrics has joined our sleep group
to expand our capabilities in this discipline. The sleep
group is committed to promoting sleep research and
education. We were pleased to hear in 2007 that our application for a fellowship in sleep medicine was approved
by the American Council on Graduate Medical Education. Board certification in Sleep Medicine will now be
approved by the American Board of Internal Medicine,
Neurology and/or Psychiatry. We anticipate that we will
be accepting applications to our sleep training program
for eligibility in Sleep Medicine from physicians trained
in pulmonary medicine, internal medicine, neurology
or psychiatry in the near future. As part of the Sleep
Program expansion and new areas of research, two new
faculty members were added, Katherine Sharkey M.D.,
Interventional Pulmonology
Pulmonary Critical Care Fellowship
Nicholas Ward M.D., Program Director for the Fellowship Program at RIH, continues with his highlysuccessful work in recruiting four fellows each year for
the three-year training program. Our recent recruits, in
addition to two Brown graduates, are from Beth Israel
and St. Vincent’s. The fellows continue to present their
research each year at a national meeting and have a successful track record of publications, by the end of their
fellowship.
We have continued our collaboration with the Division
of Hematology/Oncology through Dr. Peter Quesenberry and Dr. Jason Aliotta, Professors of Medicine. The
Hematology/Oncology Division continues to work
with a COBRA grant, The New Stem Cell Biology. Dr.
Aliotta, a former pulmonary/critical care fellow, is now
the holder of a K grant entitled, Injured Lung and its
Influence on Bone Marrow Cell Phenotype, and he is
working on submitting his RO1. Dr. Aliotta has become
a highly-regarded and well-respected bench researcher.
The main focus of his research is to examine the contribution of bone marrow-derived stem cells to the cellular
component of the radiation-injured murine lung.
Sharon Rounds, M.D.: Dr. Sharon Rounds, Professor
of Medicine, and Chief of the Medical Service at the
Providence VA Medical Center, is the principal investigator in an NIH sponsored grant entitled “Short-term
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p u l m o n a r y, c r i t i c a l c a r e a n d s l e e p m e d i c i n e
training program to increase diversity in health-related
research.” She has been a member of several NIH committees including data safety monitoring boards for
clinical research projects, a strategic planning working group on integrative approaches to pathogenetic
research and also a special emphasis panel on training grants. She has continued to be very active in the
American Thoracic Society since stepping down as
President of the organization. She has chaired its membership committee and also been the Vice-chair of the
scientific advisory committee. Dr. Rounds has chaired
the ATS Scientific Advisory Committee since 2008. She
also received a Scientific Achievement Award from the
American Thoracic Society in May, 2009.
Linda Nici, M.D.: Dr. Linda Nici, Clinical Professor of
Medicine, continues her highly-successful pulmonary
rehabilitation program at the VA Medical Center. Her
research in the area of pulmonary rehabilitation has
explored the relationship of pulmonary hypertension and
impairment of functional improvement in patients with
COPD. Dr. Nici is Associate Chief of the Pulmonary/
Critical Care section at the Providence VA Medical Center.
She is Medical Director of Respiratory Therapy at the VA.
Kevin Dushay, M.D.: Dr. Kevin Dushay, Assistant
Professor of Medicine, continues his work with the New
England Organ Bank and has now entered several clinical trials on interstitial pulmonary fibrosis.
Sidney Braman, M.D.: Dr. Sidney Braman, Professor
of Medicine, continues as “GlaxoSmithKline Distinguished Scholar in Respiratory Health Award” by The
American College of Chest Physicians and The CHEST
Foundation, its philanthropic arm. This endowed
scholars program provides financial support for clinical
educational projects that will improve patient care. As
the ACCP Distinguished Scholar, Dr. Braman will
represent the College membership and will complete a
project that will impact the College’s global membership
by offering improved methods of practice and medical education. The goal of the project is to develop a
COPD Chronic Care Model. The vision is to have this
integrative model of care for COPD patients used by
primary care physicians and other health care providers
throughout the country. The Model will encourage high
quality, evidence-based and guideline driven chronic
disease management and the use of ACCP educational
resources. The COPD Chronic Care Model will be developed by creating a partnership with the Institute for
110
Health Care Improvement (IHI) in Cambridge, MA
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Professors
Sidney Braman, M.D.
Mitchell Levy, M.D.
F. Dennis McCool, M.D.
Richard Millman, M.D.
Sharon Rounds, M.D.
Associate Professors
E. Jane Carter, M.D. *
Vera De Palo, M.D.
Elizabeth Harrington, Ph.D.
James Klinger, M.D.
Eleanor Summerhill, M.D.
Nicholas Ward, M.D.
Assistant Professors
Yaser Abu El-Sameed, M.D.
Jason Aliotta, M.D. **
Gerardo Carino, M.D., Ph.D.
Brian Casserly, M.D.
Kevin Dushay, M.D.
Mariam Louis, M.D.
Qing Lu, Ph.D., D.V.M.
Jigme Sethi, M.D.
Katherine Sharkey, M.D., Ph.D.
*Joint Appointment in Infectious Disease
**Joint Appointment with Hematology/Oncology
Clinical Faculty
(Hospital and Foundation Based)
Professors
Linda Nici, M.D.
Associate Professors
Alice Bonitati, M.D.
Amos Charles, M.D.
Assistant Professors
Muhanned Abu-Hijleh, M.D.
Brian Kimble, M.D.
Adrian Salmon, M.D.
Patrick Weyer, M.D.
Instructors
Matthew Jankowich, M.D.
a c a d e m i c y e a r s 20 08 a n d 20 09
Volunteer Clinical Faculty
Sidney Braman, M.D.
Professors
William Corrao, M.D.
Honors And Awards
Associate Professors
Walter Donat, M.D.
David Ettensohn, M.D.
James Myers, M.D.
Charles Sherman, M.D., MPH
Assistant Professors
R. William Corwin, M.D.
Ronald Gilman, M.D.
Peter Karczmar, M.D.
Naomi Kramer, M.D.
John Ladetto, M.D.
Michael Pomerantz, M.D.
Michael Stanchina, M.D.
Instructors
John Zwetchkenbaum, M.D.
Adjunct Faculty
Nicholas Hill, M.D.
Joseph Meharg, M.D.
Michael Passero, M.D.
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Muhanned Abu-Hijleh, M.D.
Honors And Awards
◆◆
Beckwith Family Award for Outstanding
Teaching, Alpert Medical School, 2008
Invited Pr esentations
◆◆
“Bronchoscopy Update” at The Jordanian
Respiratory Society, Amman, Jordan
Jason Aliotta, M.D.
Honors And Awards
◆◆
Elected Fellow of the American College
of Chest Physicians (FCCP)
◆◆
Dean’s Teaching Excellence Award, Pulmonary
Pathophysiology Small Group, Alpert
Medical School, 2007, 2008, 2009
“Tissue-Specific Gene Expression of Marrow Cells
Co-Cultured with Various Murine Organs” at
American Society of Hematology, San Francisco, CA
◆◆
“The Lung and Bone Marrow: Microvesicles
and their role in cellular communication” at
Experimental Biology, New Orleans, LA
j u ly 1 , 20 07 – j u n e 30 , 20 09
◆◆
GlaxoSmithKline Distinguished Scholar
in Respiratory Health Award presented by
the American College of Chest Physicians
and The CHEST Foundation
◆◆
United Nations Environment Programme
Medical Applications Technical
◆◆
Options Committee
Invited pr esentations
◆◆
◆◆
◆◆
“Clinical Manifestations of Asthma
vs. COPD in the Elderly” at National
Institute of Aging, Washington, DC
American College of Chest Physicians International
Board Review Course, Athens, Greece
“The Physiologic Consequences of Asthma”, “Selfeducation and evaluation of knowledge (SEEK)
Question Review”, “Aspirin Sensitive Asthma”
Symposium Chair, and “Year in Review: COPD” at
American College of Chest Physicians Annual Meeting,
ACCP Fellows Asthma Course, Philadelphia, PA
Schol arly Activities
◆◆
Advisory Committee, National Institute of Aging
E. Jane Carter, M.D.
Honors and Awards
◆◆
President Elect, North American Region,
International Union Against TB and Lung Disease
Schol arly Activities
◆◆
Liaison Member- Advisory Committee for
the Elimination of Tuberculosis, CDC
◆◆
Board Member- World Lung Foundation
◆◆
Advisory Committee Member (Tuberculosis)
- Millennium Village Project
◆◆
Technical Consultant in TB and TB/HIV,
USAID PEPFAR AMPATH, Eldoret, Kenya
◆◆
Reviewer: American Journal of Respiratory and
Critical Care Medicine, PLOS, The International
Journal of Tuberculosis and Lung Disease
Kevin Dushay, M.D.
Invited Pr esentations
◆◆
The DCD Experience: Hospital and Donor Family
Perspectives” at New England Organ Donation
and Transplantation Breakthrough Collaborative
Local Learning Congress, Westborough, MA
◆◆
“Creating Future Donation Champions”,
Collaborating to Save Multiple Lives: The Vital
Role of the Intensivist in Maximizing Organs
at Transplant Conference, Baltimore, M.D.
Invited Pr esentations
◆◆
◆
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◆◆
◆◆
“Research Opportunities for the Intensivist”,
Collaborating to Save Multiple Lives: The Vital
Role of the Intensivist in Maximizing Organs
at Transplant Conference, Baltimore, M.D.
“Lung Recruitment Strategies” at National
Association of Transplant Coordinators
2008 Annual Meeting, Boston, MA
Elizabeth Harrington, Ph.D.
Honors And Awards
◆◆
Associate Editor, Lung
◆◆
Member, Nomination Committee, Assembly on
Pulmonary Circulation, American Thoracic Society
◆◆
Member, Program Committee, Assembly on
Pulmonary Circulation, American Thoracic Society
James Klinger, M.D.
Honors And Awards
◆◆
Elected Vice-chair of the ACCP
pulmonary vascular disease network
◆◆
Co-chair postgraduate course on
pulmonary hypertension, ATS International
meeting, San Diego, CA
◆◆
Co-chair ATS symposium on right ventricular
function, ATS International meeting, San Diego, CA
Invited Pr esentations
◆◆
Keynote speaker, 3rd annual pulmonary hypertension
and advanced lung disease conference, Northshore
University Hospital, Long Island, NY
◆◆
Dartmouth-Hitchcock Medical Center,
Cardiology Division, Hanover, NH
Invited Pr esentations
◆◆
◆◆
◆◆
“The Role of PKC in Endothelial Cell
Function” (Visiting Professor) for the
Committee on Molecular Medicine at
University of Chicago, Chicago, IL
“Endothelial Cell Apoptosis and Lung Injury” (Featured
Speaker) at American Thoracic Society International
Conference, Mini-symposium on Advances in Basic
Mechanisms of Pulmonary Edema, Toronto, Canada
Mitchell Levy, M.D.
Honors And Awards
◆◆
Top Doctors of Rhode Island, (Critical
Care) Rhode Island Monthly, 2006
◆◆
Elected to Best Doctors in America: specialists
considered by peers to be in the top 5% of
physicians; accredited by the Accreditation
Council for Continuing Medical
Education (ACCME®), 2007–2008.
Schol arly Activities
◆◆
Invited Pr esentations
◆◆
Co-Chair, American Thoracic Society
International Conference, Poster Discussion
Session entitled “Cellular and Molecular
Events in Pulmonary Hypertension”
20th ESICM (European Society Intensive
Care Medicine) Annual Congress,
Oct 2007, Berlin, Germany
◆◆
◆◆
Ad hoc Reviewer, Heart, Lung, and Blood Program
Project Review Committee, NIH, NHLBI
14th Annual National Conference of
Indian Society of Critical Care Medicine,
February 2008, Bhopal, INDIA.
◆◆
◆◆
Co-Chair, American Thoracic Society International
Conference, Poster Discussion Session entitled
“Regulation of Pulmonary Vascular Cell Proliferation,
Migration, Apoptosis and Contraction”
13th International Symposium on Infections in the
Critically Ill Patient, February 2008, Athens, GREECE.
◆◆
2008 Kern Visiting Professorship in Critical Care
and Glen Duffie Memorial Lecture: Distinguished
Visiting Professor, April 2008, Portland OR.
◆◆
Facilitator, American Thoracic Society
International Conference, Thematic Poster
Session “Lung Vascular Endothelial Function,
Lung Injury and Pulmonary Edema”
◆◆
XIII Brazilian Congress of Intensive Care
Medicine, May 2008, Salvador, Bahia, BRAZIL.
◆◆
ATS 2008 International Conference (invited
speaker), May 2008, Toronto, Canada.
◆◆
Fifth International Sepsis Forum (invited
speaker), June 2008, São Paulo Brazil
◆◆
ESICM 21st Annual Congress (invited
speaker), Sep 2008, Lisbon Portugal
◆◆
Criticare 2009, Int’l Critical Care Congress & 15th
Annual Conference of Indian Society of Critical
Care Medicine. Feb 2009, Agra, India
◆◆
◆◆
112
Ad hoc Reviewer, Research Career
Development Subcommittee for Respiration,
Department of Veterans Affairs
Ad hoc Reviewer, Center For Scientific Review
Special Emphasis Panel, Fellowships: Physiology and
Pathobiology of Organ Systems—Cardiovascular,
Pulmonary and Hematology, NIH, ZRG1 F10-H (21)
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
3rd Congress of Critical Care Medicine
of China, May 2009, Harbin, China
◆◆
Scholarly Activities
◆◆
President, Society of Critical Care Medicine, 2009.
◆◆
Manuscript Reviewer:
New England Journal of Medicine
Critical Care Medicine
CHEST
Critical Care
Journal of Critical Care
Intensive Care Medicine
◆◆
Faculty, Second American Cough
Conference, New York, New York
◆◆
Department of Medicine Promotion Committee,
The Alpert Medical School of Brown University
◆◆
Admissions Committee, The Alpert
Medical School of Brown University
Richard Millman, M.D.
Invited Pr esentations
◆◆
Visiting Professor, Sleep Symposium at
Simmons College, Boston, MA
◆◆
“A Practical Approach to Insomnia” Grand Rounds
at Lankenau Hospital, Philadelphia, PA
◆◆
“Pro/Con: Should You Treat Mild Sleep
Apnea” at Northeast Sleep Society 23rd
Annual Conference, Newton, MA
Qing Lu, Ph.D., D.V.M.
Invited Pr esentations
◆◆
◆◆
“Receptor characterization of adenosinemediated protection against pulmonary
edema” at American Thoracic Society 104th
International Conference, Toronto, Canada
“Pentostatin enhances endothelial baseline
barrier function through Rac-1 activation”
at American Thoracic Society 105th
International Conference, San Diego, CA
Linda Nici, M.D.
Honors And Awards
◆◆
Chair, Pulmonary Rehabilitation Assembly
of the American Thoracic Society and
Member, ATS Board of Directors
◆◆
Elected recipient of the Career Achievement
Award of the 6th Québec International
Symposium on Cardiopulmonary Prevention
/ Rehabilitation, Montreal, Canada
Schol arly Activities
◆◆
Member, American Heart Association Northeast
Consortium 1B Peer Review Committee
◆◆
Member, American Heart Association
REGION I Molecular Signaling 2 Study
Group Peer Review Committee
◆◆
Member, American Heart Association Region 1
Molecular Signaling Peer Review committee
◆◆
Grant Reviewer for National Priorities Research
Program, Qutar National Research Fund
Invited pr esentations
◆◆
“Exercise and Pulmonary Rehabilitation” Clinical
Year in Review at American Thoracic Society
International Conference, Toronto, Canada
◆◆
Visiting Professor: International Meeting of
Cardiopulmonary Rehabilitation; National Institute
of Respiratory Disease (INER), Mexico City, Mexico
◆◆
Chair: ATS Workshop “The Integrated Care of
the COPD Patient” at American Thoracic Society
International Conference, San Diego, CA
F. Dennis McCool, M.D.
Honors And Awards
◆◆
Editor-in-Chief, LUNG
Schol arly Activities
◆◆
Invited pr esentations
◆◆
“Emerging Concepts in Clinical Cough” Moderator,
Second American Cough Conference, New York, NY
◆◆
“Diaphragm Ultrasound; Current and Future
Applications” Pulmonary Research Seminar, St
Elizabeth’s Medical Center, Boston, MA
◆◆
“Non-Invasive Measures of Ventilation”
Research Seminar, Ventura, CA
j u ly 1 , 20 07 – j u n e 30 , 20 09
Schol arly Activities
Journal of the American Medical Association
American Journal of Respiratory &
Critical Care Medicine
◆
International Advisory Board, CIRO Horn Centre
for Rehabilitation for Patients with Chronic
Organ Failure, Maastricht, The Netherlands
Sharon Rounds, M.D.
Honors And Awards
◆◆
Scientific Achievement Award,
American Thoracic Society
◆◆
Listed in Best Doctors in America
◆◆
Editorial Board: American Journal of
Respiratory and Critical Care Medicine
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Invited Pr esentations
◆◆
Visiting Professor, University of South
Alabama, Lung Biology Center, Mobile, AL
◆◆
Inkley Lecturer and Visiting Professor, Case
Western Reserve University, Cleveland, OH
◆◆
Primary Investigator, “Pulmonary and Critical
Care Physician Preparedness for Disaster: A
Survey of the ACCP Membership.” Sponsored
by the American College of Chest Physicians.
◆◆
Site Primary Investigator, “Improving Quality
of Care for Elderly Patients in the Educational
Setting.” Sponsored by the ABIM Foundation
and the Josiah Macy, Jr. Foundation.
Schol arly Activities
◆◆
NIH:
Member, Special Emphasis Panel on
T35 Training Grants, NHLBI
Member, Special Emphasis Panel on Sickle
Cell Disease Grants, NHLBI
Member, Data Safety Monitoring Board of
Pulmonary Fibrosis Network, NHLBI
Member, NHLBI Institutional Training
Mechanism Review Committee
Member, Data Safety Monitoring Board
of Specialized Centers for Clinically
Oriented Research (SCCOR), NHLBI
Ad hoc Member, Special Emphasis
Panel for Program Project Grant
◆◆
Nicholas Ward, M.D.
Honors And Awards
◆◆
International Congress Program Committee
Presidential Citation for Outstanding Contributions
International Congress Committee, Co-Chairman
◆◆
◆◆
“Spirituality in the ICU” at Society of Critical
Care Medicine 37th Critical Care Congress,
speaker, Moderator, Oral abstract session,
“Epidemiology and Outcomes”, Honolulu, HI
◆◆
“Optimal PEEP in ARDS: a fool’s errand.” At
Society of Critical Care Medicine 38th
Critical Care Congress, Nashville, TN
◆◆
“End-of-Life in the ICU” at Society of Critical Care
Medicine 38th Critical Care Congress, for Adult
Critical Care Refresher course, Nashville, TN
Vice-Chair, Scientific Advisory Committee
◆◆
University of California: Member, Study Section,
Tobacco-Related Disease Research Program
Katherine Sharkey, M.D., Ph.D.
Invited Pr esentations
◆◆
“Timing is Everything: Applying Circadian
Rhythms Science to Duty Hour Requirements in
Medical Training” at National Institutes of Health
Clinical Center Grand Rounds, Bethesda, M.D.
Eleanor Summerhill, M.D.
S ELEC T ED P U B LICAT ION S
Yaser Abu El-Sameed, M.D.
◆◆
Invited pr esentations
◆◆
“Disaster Preparedness and Training in
the ICU” at American College of Chest
Physicians, Philadelphia, PA
◆◆
“Outcome-Based Delivery of Critical Care:
Facing the Challenge” at American College
of Chest Physicians, Philadelphia, PA
◆◆
“COPD Management”. Moderator, poster
session at American College of Chest
Physicians, Philadelphia, PA
Schol arly Activities
◆◆
114
Primary Investigator, “Biodefense and Disaster
Preparedness training for Internal Medicine
Residents”. Sponsored by the RI Dept of Health.
Elected Fellow of the American College
of Critical Care Medicine
Invited Pr esentations
American Thoracic Society:
Chair, Scientific Advisory Committee
Society of Critical Care Medicine
Jankowich M, Abu El-Sameed Y, Abu-Hijleh
M. A 21-year-old man with fever and sore
throat rapidly progressive to hemoptysis and
respiratory failure. Chest 2007; 132(5):1706–9.
Muhanned Abu-Hijleh, M.D.
◆◆
Abu-Hijleh M, Lee D, Braman SS.
Tracheobronchopathia osteochondroplastica: A rare
large airway disorder. Lung 2008; 186(6):353–9.
◆◆
Jankowich M, Abu El-Sameed Y, Abu-Hijleh
M. A 21-year-old man with fever and sore
throat rapidly progressive to hemoptysis and
respiratory failure. Chest 2007; 132(5):1706–9.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
PULMONARY/CRITICAL CARE MEDICINE FELLOWSHIP PROGRAM
Nicholas Ward, M.D., Program Director
Jason Aliotta, M.D., Associate Program Director
Current Fellows
Fellow
Medical School
Residency
Frankie Alvarado, M.D.
Universidad Autonoma
De Guadalajara
San Juan VA Medical Center
Michael Blundin, M.D.
PA State University
College of Medicine
Brown Alpert Medical School (RIH)
Brian Casserly, M.D.
University College Dublin
Tufts New England Medical Center
Sam Faradyan, M.D.
George Washington University
St. Elizabeth Medical Center
Vadim Fayngersh, M.D.
Ben Gurion University
Brown Alpert Medical School (RIH)
Eric Gartman, M.D.
University of Rochester
Brown Alpert Medical School (RIH)
Theresa Glidden, M.D.
University of Massachusetts
University of Massachusetts
Sam Hamade, M.D.
Universidad Iberoamericana
SUNY Upstate Medical University
Brian Horner, D.O.
UM.D.NJ/School of Osteopathic
Medicine
Temple University Hospital
Wee Lee, M.D.
University of Calgary
St. Vincent’s Hospital
Andrew Levinson, M.D.
Drexel University
Brown Alpert Medical School (RIH)
Douglas Martin, M.D.
University of Rochester
Brown Alpert Medical School (RIH)
Jeffrey Mazer, M.D.
Tufts University
Brown Alpert Medical School (RIH)
Nureain Mirza, M.D.
Dow Medical College
St. Barnabas Hospital
Napoleon Puente Cuellar, M.D.
Universidad Dr. Jose Matias Delgado
Roger Williams Medical Center
Richard Read, M.D.
McGill University
McGill University
Frederick Troncales, M.D.
University of Santo Tomas
Brown Alpert Medical School (MEM)
Graduating Fellows
2009 Graduates
Postgraduate Plans
Vadim Fayngersh, M.D.
Private practice, Denver, CO
Jeffrey Mazer, M.D.
Academic position at Miriam Hospital
Nureain Mirza, M.D.
Private practice, Chicago, IL
2008 Graduates
Postgraduate Plans
Brian Casserly, M.D.
Academic position at Memorial Hospital of RI
Sam Faradyan, M.D.
Private practice, New Hartford, NY
Theresa Glidden, M.D.
Private practice, Milford, MA
Brian Horner, M.D.
Private practice, Charlotte, NC
115
p u l m o n a r y, c r i t i c a l c a r e a n d s l e e p m e d i c i n e
S ELEC T ED P U B LICAT ION S
c o nti n u e d
Matthew Jankowich, M.D.
◆◆
Jankowich M.D., Wahidi MM, Feller-Kopman
D, Ernst A. Pulmonary alveolar proteinosis
diagnosed in pregnancy and managed with
whole-lung lavage. J Bronchol 2006; 13: 204–6.
◆◆
Jankowich M, Sameed YA, Abu-Hijleh,
M. A 21-year-old man with fever and sore
throat rapidly progressive to hemoptysis and
respiratory failure. Chest 2007; 132: 1706–9.
◆◆
Jankowich M., Polsky M., Klein M., Rounds S.
Heterogeneity in combined pulmonary fibrosis
and emphysema. Respiration; 2008; 75: 411–17.
Jason Aliotta, M.D.
◆◆
◆◆
◆◆
Aliotta JM, Sanchez-Guijo FM, Dooner GJ,
Johnson KW, Dooner MS, Greer KA, Greer D,
Pimentel J, Kolankiewicz LM, Puente N, Faradyan
S, Ferland P, Bearer EL, Passero MA, Adedi
M, Colvin GA, Quesenberry PJ. Alteration of
marrow cell gene expression, protein production
and engraftment into lung by lung-derived
microvesicles: A novel mechanism for phenotype
modulation. Stem Cells 2007; 25(9):2245–56.
Dooner MS* , Aliotta JM*, Pimentel J, Dooner GJ,
Abedi M, Colvin GA, Liu Q, Weier HU, Johnson
KW, Quesenberry PJ. Cell cycle related differentiation
of bone marrow cells into lung cells. Stem Cell
Dev 2008; 17(2):207–20. *Equal Contributions
Aliotta JM, Keaney PJ, Warburton RR, Del Tatto M,
Dooner MS, Passero MA, Quesenberry PJ, Klinger JR.
Marrow cell infusion attenuates vascular remodeling in
a murine model of monocrotaline-induced pulmonary
hypertension. Stem Cell Dev 2009; 18(5):773–82.
James Klinger, M.D.
◆◆
Aliotta JM, Keaney PJ, Warburton RR, DelTatto
M, Dooner MS, Passero MA, Quesenberry
PJ, Klinger JR. Marrow cell infusion attenuates
vascular remodeling in a murine mode of
monocrotaline-induced pulmonary hypertension.
Stem Cells Dev 2009; Jun:18(5):773–82.
◆◆
Klinger JR, Murray JD, Casserly B, Alvarez DF,
King JA, An SS, Choudhary G. Owusu-Sarfo
AN, Warburton R, Harrington EO. Rottlerin
causes pulmonary edema in vivo: a possible role for
PKCdelta. J Appl Physiol 2007; Dec:103(6):2084–94.
Sidney Braman, M.D.
◆◆
◆◆
Braman SS, Hanania NA. Asthma in older
adults. Clin Chest Med 2007; 28(4):685–02.
Mannino DM, Braman SS. The epidemiology
and economics of chronic obstructive pulmonary
disease. Proc Am Thorac Soc 2007; 4(7):502–6.
Mitchell M. Levy, M.D.
◆◆
Antonelli M, Levy M, Andrews PJD, Chastre
J, Hudson LD, Manthous C, Meduri GU,
Moreno RP, Putensen C, Stewart T, Torres
A. Hemodynamic monitoring in shock and
implications for management—International
Consensus Conference, Paris, France, 27–28
April 2006. Int Care Med 2007;33:575–590.
◆◆
Dellinger RP, Levy MM, Carlet JM, Bion J, Parker
MM, Jaeschke R, Reinhart K, Angus D, BrunBuisson C, Beale R, Calandra T, Dhainaut, J-F,
Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri
M, Ramsay G, Sevransky J, Thompson T, Townsend
S, Vender JS, Zimmerman JL, Vincent J-L, for the
International Surviving Sepsis Campaign Guidelines
Committee. Surviving Sepsis Campaign: International
guidelines for management of severe sepsis and
septic shock: 2008. Crit Care Med 2008;36:296–327.
◆◆
Levy MM, John Rapoport, Stan Lemeshow,
Donald Chalfin, Gary Phillips, and Marion Danis.
Association between Critical Care Physician
Management and Patient Mortality in the Intensive
Care Unit. Ann Intern Med 2008;148:801–809.
Braman SS, Vigg A. The National Asthma
Education and Prevention Program (NAEPP)
guidelines: Will they improve the quality of care
in America? Med Health RI 2008; 91(6):166–8.
E. Jane Carter, M.D.
◆◆
Kwara A, Herold JS, Machan JT, Carter EJ. Factors
Associated with Failure to Complete Isoniazid
Treatment for Latent Tuberculosis Infection
in Rhode Island. Chest 2008; 133:862–8.
Elizabeth Harrington, Ph.D.
◆◆
116
Klinger, JR, Murray, JD, Casserly, B, Alvarez, DF,
King, JA, An, SS, Choudhary, G, Owusu-Sarfo,
AN, Warburton, R, Harrington, EO. Rottlerin
causes Pulmonary Edema in vivo: A Possible Role
for PKCd. J Appl Physiol 2007; 103:2084–94.
◆◆
Simon, A, Harrington, EO, Liu, G-X, Koren,
G, Choudhary, G. Mechanisms of C-type
Natriuretic Peptide-Induced Endothelial Cell
Hyperpolarization. Am J Physiol 2009; 296:L248–56. ◆◆
Lu Q, Harrington EO, and Rounds S. TGF-b1
Causes Pulmonary Microvascular Endothelial Cell
Apoptosis via ALK5. Am J Physiol 2009; 296:L825–38.
a c a d e m i c y e a r s 20 08 a n d 20 09
Qing Lu, Ph.D., D.V.M.
◆◆
Lu Q, Harrington EO, Newton J, Jankowich
M, and Rounds S. Inhibition of ICMT induces
endothelial cell apoptosis through GRP94. Am
J Respir Cell Mol Biol 2007; 37: 20–30.
◆◆
Lu Q. Transforming growth factor-b1 protects against
pulmonary artery endothelial cell apoptosis via ALK5.
Am J Physiol Lung Cell Mol Physiol 2008; 295, L123–33.
◆◆
Lu Q, Patel B, Harrington EO, and Rounds
S. TGF-β1 causes pulmonary microvascular
endothelial cell apoptosis via ALK5. Am J Physiol
Lung Cell Mol Physiol 2009; 296: L825–38.
F. Dennis McCool, M.D.
◆◆
Summerhill, E.M., Angov N., Garber C., McCool,
F.D. Respiratory muscle strength in the physically
active elderly. LUNG 2007; 185(6): 315–20
◆◆
Summerhill, E.M., Abu el-Sameed Y., Glidden, T.J.,
McCool, F.D. Monitoring recovery from diaphragm
paralysis with ultrasound Chest 2008; 133(3): 737–43
◆◆
McCool, F.D. Cough, Basic Science, and the
Clinician. . LUNG 2008; 186(2): 73–4
◆◆
McCool FD, Ayas N, Brown R. Mechanical
ventilation and disuse atrophy of the diaphragm.
N Engl J Med 2008; Jul 3;359(1):89
◆◆
◆◆
◆◆
Aloia MS, Smith K, Arnedt JT, Millman R
et al. Brief behavioral therapies reduce early
PAP discontinuation rates in SAS: Preliminary
findings. Behav Sleep Med 2007; 5:89–104
Aloia MS, Goodwin MS, Velicer WF, Arnedt
JT, Zimmerman M, Millman RP. Time series
analysis of treatment adherence patterns
in individuals with obstructive sleep apnea.
Ann Behavioral Med 2008; 36:44–53
Foster G, Sanders M, Millman R et al. Obstructive
sleep apnea among obese patients with Type
2 diabetes. Diabetes Care 2009; 32:1017–19
Linda Nici, M.D.
◆◆
Nici L, Limberg T, Hilling L et al.
Clinical Competencies for Pulmonary
Rehabilitation Professionals. J Cardiopulm
Rehab Prevention 2007; 27(6):355–58.
◆◆
Nici L. The major limitation to exercise performance
in COPD is inadequate energy supply to the
respiratory and locomotor muscles vs. lower limb
muscle dysfunction vs.dynamic hyperinflation.
Difficulties in determining the primary physiological
abnormality that limits exercise performance
in COPD. J Appl Physiol 2008; 105(2):760–1.
j u ly 1 , 20 07 – j u n e 30 , 20 09
Nici L, ZuWallack R, Rochester C, Raskin
J, et al. Pulmonary Rehabilitation: What we
know and what we need to know. J Cardiopulm
Rehab Prevention 2009; 29(3): 141–51.
Sharon Rounds, M.D.
◆◆
Jankowich M.D., Polsky M, Klein M, Rounds
S. Heterogeneity in combined pulmonary fibrosis
and emphysema. Respiration 2008; 75:411–7.
◆◆
Martin K, Stanchina M, Harrington EO, Koutaub
N, Rounds S. Circulating Endothelial Cells
and Endothelial Progenitor Cells in Obstructive
Sleep Apnea. Lung 2008; 186:145–50.
◆◆
Lu Q, Patel B, Harrington EO, Rounds S.
Transforming Growth Factor-β1 Causes Pulmonary
Microvascular Endothelial Cell Apoptosis via
ALK5. Am J Physiol 2009; 296:L825–38.
Katherine Sharkey, M.D., Ph.D.
◆◆
Sharkey KM, Kurth ME, Corso RM, Brower KJ,
Anderson BJ, Millman RP, Stein M.D.. Home
Polysomnography in Methadone Maintenance
Patients with Subjective Sleep Complaints. Am
J Drug Alcohol Abuse 2009; 35(3): 178–82.
◆◆
Kurth ME, Sharkey KM, Corso RM, Anderson
BJ, Millman RP, Stein M.D.. Insomnia
among methadone-maintained persons: The
feasibility of collecting home PSG recordings.
J Addict Dis 2009; 28(3): 219–25.
Richard Millman, M.D.
◆◆
◆
Eleanor Summerhill, M.D
◆◆
Summerhill EM, Angov N, Garber C, McCool
FD. Respiratory muscle strength in the physically
active elderly. Lung 2007; 185(6):315–20.
◆◆
Summerhill EM, Abu El-Sameed Y, Glidden TJ,
McCool FD. Monitoring recovery from diaphragm
paralysis with ultrasound. Chest 2008; 133(3):737–43.
◆◆
Nemr S, Modesto MM, Schwartz S, Summerhill
EM. A 92-year old woman with recurrent
pleural effusions. Chest 2008; 134(1):196–9.
Nicholas S. Ward, M.D.
◆◆
Ward, NS, and Levy, MM. Rationing in
Critical Care Medicine, Crit Care Med
2007; Feb;35(2 Suppl):S102–5.
◆◆
Ward, NS, Teno, JM, Curtis, JR, Rubenfeld,
GD, Levy MM. Perceptions of Cost Constraints,
Resource Limitations, and Rationing in United
States Intensive Care Units: results of a National
survey. Crit Care Med 2008; 36(2):471–6.
◆◆
Ward, NS and Dushay, K. Concise Definitive
Review: COPD and Mechanical Ventilation.
Crit Care Med 2008; 36(5):1614.
117
p u l m o n a r y, c r i t i c a l c a r e a n d s l e e p m e d i c i n e
RESEARCH
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$641,341
$521,200
$113,368
$127,830
$752,709
$649,030
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$1,003,288
$579,411
$216,791
$127,536
$1,220,080
$940,778
S ELEC T ED
B A S IC RE S EARCH
Qing Lu, Ph.D., D.V.M.
◆◆
Jason Aliotta, M.D.
◆◆
Injured Lung and its Influence on Bone Marrow Cell
Phenotype, National Heart, Lung, and Blood Institute
Sharon Rounds, M.D.
◆◆
Small GPTASES and Lung Endothelial Apoptosis,
National Heart, Lung, and Blood Institute
◆◆
Short-Term Training Program to Increase
Diversity in Health Related Research, National
Heart, Lung, and Blood Institute
◆◆
RhoA GTPase Methylation and Vascular
Permeability, National Institutes of Health
◆◆
Lung Endothelial Cell Apoptosis and
Emphysema, Department of Veterans Affairs
Gaurav Chaudhary, M.D.
◆◆
Role of C-Type Natriuretic Peptide in Pulmonary
Vascular Function, Department of Veteran Affairs
Elizabeth Harrington, Ph.D.
◆◆
Endothelial Barrier Function Modulation
by PKCDELTA, National Heart,
Lung, and Blood Institute
◆◆
P190RhoGAP and PKC: Investigating
Their Role in Endothelial Barrier Function,
American Heart Association
◆◆
Signaling Mechanisms Regulating Hypoxic
Pulmonary Microvascular Endothelium,
Department of Veterans Affairs
James Klinger, M.D.
118
◆◆
Natriuretic Peptides in Pulmonary
Endothelial Cell Barrier Function, National
Heart, Lung, and Blood Institute
◆◆
Natriuretic Peptides in Pulmonary Endothelial
Cell Barrier Function (ARRA Supplement),
National Heart, Lung, and Blood Institute
◆◆
The Role of Natriuretic Peptide in Right Ventricular
Hypertrophy, American Heart Association
TGFbeta1 and Pulmonary Arterial
Hypertension, American Thoracic Society/
Pulmonary Hypertension Association
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
r h e um ato lo gy
OVERVIE W
T
he Division of Rheumatology has continued
its mission of patient care, Fellowship training,
resident teaching and clinical research during
this period of time. The Division has graduated its first
Fellow, Dr. Jill McClory, who finished her training
on June 30, 2009. She has successfully completed her
Rheumatology Fellowship and is currently in private
practice in North Carolina. Dr. Samuel Poon is the current second year Fellow in our Program. Dr. Elisabeth
Matson has begun her Fellowship as of July 1, 2009.
She joins the program after completing her internal
medicine residency at the University of Massachusetts
in Worcester, MA. Dr. Kerri Batra has continued her
clinical activity at 2 Dudley Street as well as at her Plain
Street office and at Women & Infants Hospital, where
she is working one half day a month in the maternal/
fetal medicine clinic. She has matured her activities at
both of these sites and has established her reputation
in these areas. Dr. Batra has also continued to lead the
Fellowship Research effort and oversees the Research
Conferences that occur on a monthly basis. Furthermore, she has begun to reorganize the continuity clinic
for the fellows in the APC clinic.
Dr. Schwartz has continued to be the Course Director
for the Supporting Structure course at Brown. This is
the second year pathophysiology course that encompasses Rheumatology, Orthopedic Surgery and Dermatology. Dr. Schwartz has performed at the highest levels at
organizing and administering this course to the second
year medical students.
The Division of Rheumatology is also engaged in research
activities. Dr. Batra has enrolled our Division in the
CORRONA database which is a large cohort of patients
with rheumatoid arthritis that are followed on a national
basis. Dr. Schwartz has continued with is PRECISION
trial which is looking at cardio vascular risk factors for
patients receiving non-steroidal anti-inflammatory medications. Dr. Lally has been conducting a clinical trial in
scleroderma using a tyrosine kinase inhibitor Dasatinib
to treat interstitial lung disease in the setting of scleroderma. Also, ongoing, in collaboration with Dr. Loran Fast
is a study looking at synovial serum and synovial fluid in
patients with rheumatoid arthritis to measure the serine
protease, granzyme B. Currently, grant applications for
further research in this area are being submitted.
Edward V. Lally, M.D., Professor of Medicine,
Director, Division of Rheumatology
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital and Foundation Based)
Professor
Edward V. Lally, M.D.
Associate Professors
Stuart Schwartz, M.D.
Assistant Professors
Kerri Batra, M.D.
Clinical Faculty
(Hospital and Foundation Based)
Assistant Professors
Iulia Grillo, M.D.
Volunteer Clinical Faculty
Associate Professors
Harold Horwitz, M.D.
Stuart Schwartz, M.D.
Assistant Professors
John M. Conti, M.D.
Adjunct Faculty
Clinton O. Chichester, Ph.D.
Harold A. Hall, M.D.
Bernard Zimmermann, M.D.
119
r h e u m at o l o g y
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Jill McClory, M.D.
◆◆
Edward V. Lally, M.D.
Honors And Awards
◆◆
Sub-chair American College of Rheumatology
Annual Meeting Planning Committee 2007–2009
◆◆
Abstracts Selection Committee Annual
European Congress of Rheumatology
Meeting, Barcelona, June 2007
◆◆
Abstract Selection Committee Annual European
Congress of Rheumatology Meeting, Paris, June 2008
Samuel Poon, M.D.
◆◆
Invited Pr esentations
◆◆
Rheumatology Grand Rounds. “Safety Issues with
Biologic Response Modifiers in Rheumatoid Arthritis”.
Winthrop Hospital, Mineola, NY, April 7, 2008.
◆◆
Rheumatology Grand Rounds. “Safety Issues with
Biologic Response Modifiers in Rheumatoid Arthritis.”
UCLA School of Medicine, LA, CA. June 21, 2008.
◆◆
Rheumatology Grand Rounds. “Scleroderma
(Systemic Sclerosis): Is There Reasons for
Optimism in 2008?” Brigham and Women’s
Hospital. Boston, September 30, 2008.
◆◆
Guest Speaker “Male Scleroderma”. Present
to Annual Scleroderma Foundation
Meeting.St. Louis, MO, July 18, 2009.
Kerri Batra, M.D.
◆◆
Batra KL, Dellaripa PF. Addressing interstitial
lung disease in the rheumatologic diseases. Journal
of Musculoskeletal Medicine. Jan 2008.
◆◆
Liao KP, Batra KL, Chibnik L, Schur PH,
Costenbader KH. Anti-CCP revised criteria
for the classification of rheumatoid arthritis.
Ann Rheum Dis. 2008, 67:1557–1561.
◆◆
Stoll et al, TNFa Inhibitors May Improve Asthma
Symptoms: A Case Series of 12 Patients with
Rheumatoid Arthritis and Asthma. Journal of
Clinical Rheumatology, 15 (4), June 2009
Edward Lally, M.D.
Elisabeth Matson, D.O.
Rheumatology Fellowship Training Program
July 1, 2009 – June 30, 2011
Medical School: University of NE College of
Osteopathic Medicine
Residency Program: University of
Massachusetts, Richard Foster, M.D.
RESEARCH
120
Rheumatology Fellowship Training Program:
July 1, 2008 – June 30, 2010.
Medical School: Mount Sinai School of Medicine
Residency: Rhode Island Hospital Internal
Medicine Residency Program
S ELEC T ED P U B LICAT ION S
RHE U M AT OLOGY
FELLO W S HIP PROGRA M
◆◆
Rheumatology Fellowship Training Program
July 1, 2007 – June 30, 2009
Medical School: American University of the
Caribbean
Residency Program: Roger Williams Medical Center
Dr. McClory has entered into private practices
as of July 1, 2009 in North Carolina.
◆◆
Cantini F, Niccolo L, Nannini C, Sclvarani
C, Olivieri I, Lally, EV. Single-center series and
systematic review of randomized controlled trials of
malignancies in patients with rheumatoid arthritis,
psoriatic arthritis, and ankylosing spondylitis receiving
therapy: Is there a
anti-tumor necrosis factor
need for more comprehensive screening procedures?
Arthritis Care and Research, 2009; 61: 801–812
α
DirectIndirectTotal
BASIC RESEARCH
Academic Year 2008
Academic Year 2009
$0
$0
$0
$0
$0
$0
CLINICAL RESEARCH
Academic Year 2008
Academic Year 2009
$7,901
$1,212
$1,575
$303
$9,876
$1,515
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
memorial
h o s p i ta l o f
rhode isl and
T
he Department of Medicine at Memorial Hospital of Rhode Island (MHRI) continues to be a
productive contributor to the academic mission
of the Brown Department of Medicine. It comprises
nearly 40 full-time academic faculty members populating nine subspecialty Divisions: Cardiology, Dermatology, Endocrinology, Rheumatology, General Internal
Medicine, Hematology/Oncology, Infectious Diseases,
Neurology, and Pulmonary/Critical Care. Two other
subspecialty divisions, Gastroenterology and Nephrology are populated by voluntary, community-based
faculty members. In all, there are nearly 130 community-based, voluntary clinical faculty members within
the Department at MHRI, including a large cadre of
primary care internists. The composition and collaborative nature of the Department ensures outstanding clinical care, valuable educational experiences for
medical students, residents, and fellows, and a fertile
environment for academic and community-based
research at MHRI.
The aforementioned “richness” of the Department of
Medicine at MHRI serves to promote its tripartite
mission of cutting-edge, community-based medical
research; outstanding medical education; and excellent clinical services to our large, diverse community.
From a clinical perspective, the Department has many
strengths. These include a nationally recognized primary stroke center that has recently received the “Gold”
award from the American Heart Association; a completely revamped and expanded Division of Cardiovascular Medicine with programs focusing on prevention,
risk reduction, advanced heart disease, vascular disease,
and other areas of great need in our community;
advanced procedural capabilities in gastroenterology
such as balloon enteroscopy (allowing for endoscopic
visualization of the entire small bowel) and endoscopic
ultrasound; a sports concussion program; an intensive care unit service staffed by trained intensivists
24 hours per day, seven days per week; and a primary
care network extending from southeastern MA to
Pawtucket, RI. Multiple faculty members are engaged
in funded research in a variety of areas such as cancer
screening, health disparities, women’s health, incarcerated populations, nursing home infections, antibioticresistant pathogens, biomedical engineering solutions
Andrew W. Artenstein, M.D., Professor of Medicine and Community Health,
Physician-in-Chief, Department of Medicine and Founding Director,
Center for Biodefense and Emerging Pathogens,
Memorial Hospital of Rhode Island
to diagnostic dilemmas, sepsis, bioterrorism, influenza,
and other emerging infectious threats. Much of this
work involves collaborations with colleagues at Brown
and other academic centers. This occurs through individual investigator relationships and through collaborative work performed at the Center for Biodefense and
Emerging Pathogens at MHRI or through the Brown
Center for Primary Care and Prevention located on
the hospital campus. Our community, rich in diversity,
has been a traditional strength of the Department of
Medicine, and it continues to provide a fertile environment for basic and clinical research, community and
public health, and clinical education. Scholarly activities among the Department’s faculty members extend
to a variety of other arenas: they edit medical journals;
serve on journal editorial advisory boards; direct
initiatives of their subspecialty societies on a national
and regional basis; edit medical textbooks; publish
extensively in the peer-reviewed literature; and develop
curricula for medical education. Additionally, they
serve in leadership roles on state, regional, national,
and international medical advisory bodies.
From a teaching standpoint, the Department of Medicine at MHRI serves as an important site for Brown
medical student core clinical clerkships in internal
medicine and is committed to excellence in medical
121
m e m o r i a l h o s p i ta l o f r h o d e i s l a n d
education, as evidenced by the fact that numerous
academic faculty members have been recognized
with Chairman’s Awards for outstanding teaching
and numerous clinical faculty have been recognized
with teaching excellence awards from Brown. MHRI
is home to a Brown-affiliated residency program in
Internal Medicine and is the sole site for the Brown
residency program in Family Medicine. The Department also serves as a training site for Brown fellows in
infectious diseases, pulmonary, and hematology-oncology. The full-time faculty members in the Department
are charged with the mission of providing a valuable
educational experience for students, residents, and
fellows in an atmosphere that fosters mentorship by
senior level faculty in all clinical arenas. Towards these
ends, the Department has developed a series of ongoing initiatives: a curriculum in professionalism; a program in professional development for faculty members;
the implementation of a quality and safety program in
which residents team with faculty mentors for performance improvement research projects; a monthly
faculty exchange with senior faculty from Rhode Island
Hospital; and a visiting professor series.
f a c u lt y m e mb e r s
Full-time Faculty
(Hospital Based)
Professors
Andrew Artenstein, M.D.
Dennis McCool, M.D.
Steve Opal, M.D.
Associate Professors
Vera De Palo, M.D.
Joseph Diaz, M.D.
Paul Levinson, M.D.
Marguerite Neill, M.D.
Eleanor Summerhill, M.D.
Assistant Professors
Jennifer Clarke, M.D.
Humera Khurshid, M.D.
Aurora Pop-Vicas, M.D.
Clinical Faculty
(Hospital Based)
Assistant Professors
Ali Akhtar, M.D.
Karen Aspry, M.D.
Bashar Bash, M.D.
Robert Burroughs, M.D.
Brian Casserly, M.D.
Shiavax Cowasji, M.D.
Ghassan Elkadi, M.D.
Iulia Grillo, M.D.
Husam Issa, M.D.
Joseph Rabatin, M.D.
Iole Ribizzi-Akhtar, M.D.
Adrian Salmon, M.D.
Kurush Setna, M.D.
Anthony Thomas, M.D.
Patrick Weyer, M.D.
Sabrina Witherby, M.D.
Joe Yammine, M.D.
Emeritus Faculty
James Crowley, M.D.
H. Denman Scott, M.D.
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a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
p r ov i d e n c e va
m edica l cen ter
OVERVIE W
T
he Department of Medicine of The Warren
Alpert Medical School of Brown University has
two components at the Providence VA Medical Center—the Medical Service and the Primary Care
Service. Sharon Rounds, M.D., is Chief of the Medical
Service, Thomas O’Toole, M.D., is Chief of the Primary
Care Service, and Satish Sharma, M.D., is Director of
Specialty and Acute Care Service for the VA New England Healthcare System (VISN 1).
The Medical Service and Primary Care faculty in Internal Medicine include physicians with both full-time
and part-time VA staff appointments. Some services
also employ contract physician staff with Brown faculty
appointments in the Department of Medicine. VAbased faculty are highly integrated within all divisions
of the Brown Department of Medicine. At the VA,
the Medical Service is also responsible for Neurology,
Dermatology, and Emergency Department services,
with physician staff with Brown faculty appointments in
Neurology and Dermatology. The Medical Service at the
VA includes 42 physician faculty plus nurse practitioners
and other ancillary personnel and support staff.
The Medical Service at the PVAMC is responsible for
all inpatient care and for medical subspecialty clinics. Covering inpatients, there are 4 Teaching Teams,
manned by house-staff from the Rhode Island/Miriam/
VA program and by house-staff from the Memorial Hospital of Rhode Island. Each teaching team works with
a hospitalist attending. The non-teaching team consists
of a physician and two nurse practitioners. In 2008–09
there were 2176 admissions to the Medical Service.
The Medical Service at the Providence VAMC is also
responsible for all medical subspecialty, dermatology,
and neurology outpatient clinics, with 32,604 visits
to clinics in 2008–09. An important recent initiative
has been “Advanced Clinic Access”, a management
tool whereby clinics meet the VA goals of New Patient
and Established Patient appointments within 30 days
of the requested date. These goals have been achieved
in medical subspecialty and primary care clinics. The
medical subspecialties have developed innovative clinics
Sharon Rounds, M.D., Professor of Medicine and of Pathology and
Laboratory Medicine, Chief of Medical Service, Providence VA Medical Center
that utilize groups of patients and multidisciplinary care
teams, such as CPAP Clinic and the Cardiovascular Risk
Reduction Clinics. Published and on-going research
from the Medical Service at the Providence VAMC has
demonstrated efficacy and enhanced patient adherence
to complex treatment regimens among patients attending these clinics.
The Primary Care service at the Providence VA Medical
Center provides primary care to 30,000 veterans at the
Providence VA site and in three community-based clinics
in Middleton, RI, New Bedford, MA and Hyannis, MA.
Each site incorporates multidisciplinary care teams that
include physicians, nurse practitioners, nurses, social
workers, pharmacists, dieticians and health techs that address chronic disease management, tele-health and remote
health care needs, along with case and care coordination.
In Providence there are 17 general internists of whom 16
have faculty appointments at Brown. Primary care serves
as a clerkship training site for MSIII students doing their
medicine ambulatory care rotation and as a primary
continuity clinic site for interns from the RIH/Miriam/
VA program and the MHRI internal medicine residency
programs. There are also several ongoing research projects
within Primary Care, including the returning veterans reintegration study, the project to reduce ambulatory care
sensitive admissions, and the homeless veteran outreach
and treatment engagement study.
123
prov idence va medic a l cen t er
The Medical and Primary Care Services at the VA hold
a Continuing Medical Education program entitled
“Update in Internal Medicine” (or “First Friday conference”) with outstanding speakers from both within
and outside the Department of Medicine who provide
clinical updates on a variety of topics important to
internists. On the “Third Friday” of each month, the
Medical Service has a Morbidity and Mortality Conference, also of great interest and importance to the medical staff, students, and trainees.
Other on-going educational activities include a full
complement of internal medicine noon house staff conferences, including the very popular Journal Club (led
by Paul Pirraglia) and Health Policy Seminars (led by
Amal Trivedi). In addition, the Cardiology Section provides popular weekly EKG reading sessions for residents.
Providence VAMC faculty members play important roles
in Brown medical student education, particularly in the
second year Pathophysiology course. Andrew Cohen leads
the Nephrology section, Matthew Jankowich and Brian
Kimble lead the Pulmonary/Critical Care section, and
Wen-Chih Wu leads the Cardiology section. Dr. Amos
Charles leads the VA site for the third year clerkship.
The Providence VA Medical and Primary Care Services train residents in Internal Medicine, Neurology,
Psychiatry and Human Behavior, and Dermatology
and fellows in cardiology, endocrinology, gastroenterology, infectious diseases, nephrology, pulmonary/critical
care, and rheumatology. In addition, PVAMC faculty
members are active in mentoring graduate students,
Ph.D. post-doctoral fellows, and medical students and
residents on research electives.
The Providence VAMC is building a new research site
for the VA/Brown Center for Restorative and Regenerative Medicine, which includes VA Medical Service faculty. This building will add 23,500 square feet of research
space at a cost of $6 million to Brown research space
resources. In addition, an addition of 1860 square feet
has been approved for the Research Building (currently
5000 square feet). These additions to VA research space
will include Department of Medicine investigators.
The VA Department of Medicine faculty members
excel in interdisciplinary research. In the basic science area, the Vascular Research Laboratory has
about $1 million per year in direct costs for research
from a variety of sources, including NHLBI, VA, and
124
private foundations. The Vascular Research Laboratory
investigators are Gaurav Choudhary, Beth Harrington,
Jim Klinger, Qing Lu, and Sharon Rounds. Another
important area of research excellence is health services
research, led by the VA Research Enhancement and
Award Program (REAP) grant investigators. The REAP
is a VA Health Services Research & Development-funded program to train junior investigators and to foster
research collaboration. Peter Friedmann, Wen-Chih
(Hank) Wu, Paul Pirraglia, and colleagues in Psychiatry
and Behavioral Medicine have done an outstanding job
building a health services research program. Another
key area of research is Gastroenterology, in conjunction with other Brown faculty colleagues. Clinical trials
research is outstanding with Dermatology leading the
way with multiple VA and NIH-sponsored multicenter
clinical trials. Neurology research has grown exponentially with PVAMC leadership of a VA multicenter trial
of robotics in MS rehabilitation, participation in the
Brown “Braingate” project, and as an important site of
other multicenter trials in rehabilitation.
FAC U LT Y M E M B ER S
Full-Time Faculty
(Hospital Based)
Professors
Andrew Cohen, M.D.
Peter Friedmann, M.D.
Sharon Rounds, M.D.
Satish Sharma, M.D.
Martin A. Weinstock, M.D., Ph.D.
Associate Professors
Elizabeth Harrington, Ph.D.
Thomas P. O’Toole, M.D.
Assistant Professors
Gaurav Choudhary, M.D.
David Dosa, M.D.
Melissa Gaitanis, M.D.
Matthew Jankowich, M.D.
Albert Lo, M.D., Ph.D.
Qing Lu, D.V.M., Ph.D.
Paul A. Pirraglia, M.D.
Kittichai Promrat, M.D.
Amal Trivedi, M.D.
Wen-Chih, Wu, M.D.
Instructors
Victor Shin, M.D.
Jeanette Smith, M.D.
a c a d e m i c y e a r s 20 08 a n d 20 09
Clinical Faculty
◆◆
2008 Member, AHA Peer Review
Committee (Region I)
◆◆
2007 Member, AHA NE Affiliate
Peer Review Committee
(Hospital Based)
Professors
Linda Nici, M.D.
Associate Professors
Amos Charles, M.D.
David Fortunato, M.D.
Nancy Freeman, M.D.
Dennis Mikolich, M.D.
Khaja Ahmed, M.D.
Assistant Professors
Tanya Ali, M.D.
Jeffrey Austerlitz, M.D.
Jacob Berger, M.D.
Dawna Blake, M.D.
Nancy Burnside
Joyce Chang, M.D.
Victoria Chang, M.D.
Patricia Cristofaro, M.D.
Wilfredo Curioso, M.D.
Guang Hu, M.D.
Brian Kimble, M.D.
Stephen Mernoff, M.D.
Paul Murphy, M.D.
John M. O’Connell, M.D.
David Pomerantz, M.D.
Michael Siclari, M.D.
Barbara Weil, M.D.
Karen Woolfall-Quin, M.D.
Instructors
Thomas Jean, M.D.
Lorna Russell, M.D.
Parviz Shavandy, M.D.
Hatem Shoukeir, M.D.
Adjunct Facult y
Harald Hall, M.D.
Bernard Zimmermann, M.D.
Honors and awards
◆◆
2008 Northwestern University Young
Investigators’ Forum - Third Prize
◆◆
2009 Member, AHA Peer Review
Committee (Region I)
John H. Hartford Foundation Scholar
Elizabeth O. Harrington, Ph.D.
Invited Pr esentations
◆◆
Visiting Professor, “The Role of PKC in Endothelial
Cell Function”, Committee on Molecular Medicine,
University of Chicago, Chicago, IL, October 1, 2007.
◆◆
Featured speaker, “Endothelial Cell Apoptosis and
Lung Injury”, American Thoracic Society International
Conference, Mini-symposium on Advances in Basic
Mechanisms of Pulmonary Edema, May 18, 2008
Schol arly Activities
◆◆
Associate Editor, Lung
◆◆
Member, Nomination Committee, Assembly
on Pulmonary Circulation, American
Thoracic Society, 2006–2008
◆◆
Member, Program Committee, Assembly
on Pulmonary Circulation, American
Thoracic Society, 2009–2010
◆◆
Ad hoc Reviewer, Research Career Development
Subcommittee for Respiration, Department
of Veterans Affairs, 2/2007, 8/2007, 3/2008.
◆◆
Ad hoc Reviewer, Heart, Lung, and Blood Program
Project Review Committee, NIH, NHLBI, 5/2007.
◆◆
Co-Chair, American Thoracic Society International
Conference, Poster Discussion Session entitled
“Regulation of Pulmonary Vascular Cell Proliferation,
Migration, Apoptosis and Contraction”, 5/2008.
◆◆
Facilitator, American Thoracic Society
International Conference, Thematic Poster
Session “Lung Vascular Endothelial Function,
Lung Injury and Pulmonary Edema”, 5/2008.
◆◆
Ad hoc Reviewer, Center for Scientific Review
Special Emphasis Panel, Fellowships: Physiology
and Pathobiology of Organ Systems—
Cardiovascular, Pulmonary and Hematology,
NIH, ZRG1 F10-H (21), 7/2008, 10/2008.
Gaurav Choudhary, M.D.
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
David Dosa, M.D.
S ELEC T ED HONOR S
AND S CHOLARLY W OR K
Honors and awards
◆
Albert Lo, M.D., Ph.D.
Invited Pr esentations
◆◆
The Role of Robot-Assisted Therapy for Upper
Extremity Rehabilitation. Noon Conference.
VA Puget Sound. Seattle, WA. May 5, 2008.
125
prov idence va medic a l cen t er
◆◆
◆◆
◆◆
At the Crossroads of Innovation: The
Promise and Challenges of Clinical Trials
in Rehabilitation Research and Patient Care.
Keynote Speaker. Shepherd Center Research
Day. Atlanta Georgia, November 11, 2008.
Designing Multisite Trials in Post Acute Stroke
Recovery: Examples from NIH and VA funded
Trials (Multidisciplinary Clinical Rehabilitation):
VA ROBOTICS. International Stroke Conference,
San Diego, CA. February 18, 2009.
Randomized Study of Robot-Assisted Treadmill
Training compared to body-weight supported
treadmill training for multiple sclerosis. Burke Medical
Research Institute, White Plains NY, March 17, 2009
Invited Pr esentations
◆◆
Speaker, “Exercise and Pulmonary Rehabilitation”
Clinical Year in Review; ATS International
Conference, Toronto, May 2008
◆◆
Visiting Professor, International Meeting of
Cardiopulmonary Rehabilitation; National
Institute of Respiratory Disease (INER),
Mexico City, Mexico; July 2008
◆◆
Chair: ATS Workshop “The Integrated Care
of the COPD Patient”; American Thoracic
Society International Conference; 2009
Schol arly Activities
◆◆
Chair, Pulmonary Rehabilitation Assembly of
the American Thoracic Society and member,
ATS Board of Directors; 2007–2009
◆◆
International Advisory Board, CIRO Horn Centre
for Rehabilitation for Patients with Chronic Organ
Failure; Maastricht, the Netherlands; 2006–
Schol arly Activities
◆◆
VA Secretarial appointee. Rotating chair
of the Neurology/Spinal Cord Injury
study section from 2006 until 2011.
Qing Lu, D.V.M., Ph.D.
Thomas P. O’Toole, M.D.
Invited Pr esentations
Honors And Awards
◆◆
American Thoracic Society 103ird International
Conference, “RhoA GTPase protects against
modulation of the unfolded protein response
(UPR) protein GRP94 upon inhibition of
isoprenylcysteine-O-carboxylmethyltransferase
(ICMT)”. May 18–23, 2007, San Francisco, CA.
◆◆
American Thoracic Society 104th International
Conference, “Receptor characterization of
adenosine-mediated protection against pulmonary
edema. May 16–21, 2008, Toronto, Canada.
◆◆
American Thoracic Society 105th International
Conference, “Pentostatin enhances endothelial
baseline barrier function through Rac-1
activation”. May 16–21, 2009, San Diego, CA.
Schol arly Activities
◆◆
Member, American Heart Association Northeast
Consortium 1B Peer Review Committee, April, 2007
◆◆
Member, American Heart Association REGION
I Molecular Signaling 2 Study Group Peer
Review Committee, April, 2008, 2009
◆◆
Grant Reviewer for National Priorities Research
Program, Qutar National Research Fund
Linda Nici, M.D.
◆◆
2008 Hospital Association of Rhode Island
(HARI) Providence VA Medical Center
Excellence in Hospital Care award
◆◆
2008 Rhode Island Disabled American
Veterans Physician of the Year award
Invited Pr esentations
◆◆
2008 Department of Health and Human Services
Expert Panel “Medical Respite Care for the Homeless”
(HHS Washington DC roundtable, March, 2008)
◆◆
AOA Visiting Professorship, University of
Puerto Rico School of Medicine,”When poverty
and health care meet: making the call for
medical professionalism” May 1 & 2, 2007
◆◆
Keynote speaker, 2nd annual CSL conference,UT
Health Sciences Center, San Antonio, TX,
“Medicine for the New Millennium. The role of
community, service and advocacy” April 2, 2009
Schol arly Activities
◆◆
Institute on Medicine as a Profession Physician
Advocacy initiative 7/1/08–6/30/11 $825,000
◆◆
Institute on Medicine as a Profession
at Columbia University
◆◆
National Program Co-Director:
Thomas P. O’Toole, M.D.
Honors And Awards
◆◆
126
Elected recipient of the Career Achievement
Award of the 6th Québec International
Symposium on Cardiopulmonary Prevention
/ Rehabilitation. Montreal; 2009.
Paul A. Pirraglia, M.D.
Schol arly Activities
◆◆
President, New England Region, Society
of General Internal Medicine
a c a d e m i c y e a r s 20 08 a n d 20 09
◆◆
Chair, VISN1 Integrated Primary Care
Mental Health Program Evaluation Team
Kittichai Promrat, M.D.
◆◆
◆◆
GI Grand Rounds, Emory University: Treatment of
Nonalcoholic Steatohepatitis (NASH), March 2008
Research Seminar: Weight reduction in Nonalcoholic
Steatohepatitis, Liver Diseases Branch, NIDDK,
National Institutes of Health, July 2008
Co-moderator, AASLD Clinical Symposium,
“Approaches to Weight Loss in NASH: When and
How Aggressive?” Digestive Diseases Week, June 2009
Schol arly Activities
◆◆
Member, Review Panel Committee: The Dr. George
A. Bray Research Scholars Award Fund 2008
◆◆
Member, NIDDK Safety Monitoring
Committee, 1-R01-DK-068598-01A1
◆◆
GI clinical champion, National VA
Colorectal Cancer Care Collaborative
Honors and awards
◆◆
2007 Milton Hamolsky Faculty Award (Given to
highest rated abstract by a faculty member at 2007
Society of General Internal Medicine Annual Meeting
◆◆
2008 Pfizer Health Policy Scholars Award
◆◆
2008 VA Health Services Research and
Development Career Development Awardee
◆◆
2009 Robert Wood Johnson VA
Faculty Scholars Program
◆◆
2009 Most Outstanding Abstract, AcademyHealth
Annual Research Meeting (Given to three highest
rated scientific abstracts of 1900 submitted to meeting)
◆◆
2009 AcademyHealth Article of the Year Award
Martin A. Weinstock, M.D., Ph.D.
Invited Pr esentations
◆◆
7th International Conference on the Adjuvent
Therapy of Malignant Melanoma and the 4th
European Association of Dermatologic Oncology
Congress, Marseille, France (Role of ultraviolet in
the different types of melanoma), June 19, 2008
◆◆
Royal Society of Medicine, London,
United Kingdom (Reducing deaths from
melanoma), November 20, 2008
◆◆
Plenary Session, 12th World Congress
on Cancers of the Skin, Tel Aviv, Israel
(Melanoma Control), May 6, 2009
Sharon Rounds, M.D.
Honors And Awards
◆◆
Scientific Achievement Award, American
Thoracic Society, 2009
Invited Pr esentations
◆◆
Visiting Professor, University of South Alabama,
Lung Biology Center, March, 2008
◆◆
Inkley Lecturer and Visiting Professor, Case
Western Reserve University, March, 2009
Schol arly Activities
◆◆
Schol arly Activities
◆◆
Chair, Special Emphasis Panel on T35
Training Grants, NHLBI, July, 2009
◆◆
Member, Special Emphasis Panel on Sickle Cell
Disease Grants, NHLBI, September, 2007
◆◆
Member, Data Safety Monitoring Board of
Pulmonary Fibrosis Network, NHLBI, 2005–Present
◆◆
Member, NHLBI Institutional Training
Mechanism Review Committee, 2007–Present
◆◆
Member, Data Safety Monitoring Board of
Specialized Centers for Clinically Oriented
Research (SCCOR), NHLBI, 2007–Present
j u ly 1 , 20 07 – j u n e 30 , 20 09
Amal Trivedi, M.D.
Invited Pr esentations
◆◆
◆
Chairman, Dermatology Field Advisory Committee,
Department of Veterans Affairs, Washington, DC
Wen-Chih Wu, M.D.
Invited Pr esentations
◆◆
“Anemia and Acute Myocardial Infarction”, Quality
Scholars Conference. Louis Stokes Cleveland Dept.
of Veterans Affairs Medical Center. May 21st, 2009.
◆◆
“Dyslipidemia in the Elderly, is it too late to
help?”, at 2009 Senior Symposium by the
Connecticut Chapter of the American Society
of Consultant Pharmacists, Ledyard, CT.
Schol arly Activities
◆◆
Ad hoc Member, Special Emphasis Panel
for Program Project Grant, 2009
◆◆
Study section member, VA HSR&D committee
A, August 18–20, 2009, Denver, CO
◆◆
Vice-Chair and Chair, Scientific Advisory
Committee, 2007–Present.
◆◆
NIH Special Emphasis Panel/Scientific Review
Group 2009/10 ZRG1 HDM-P (58) R
◆◆
Member, Study Section, Tobacco-Related
Disease Research Program, University
of California, 2007–2009
127
prov idence va medic a l cen t er
S ELEC T ED P U B LICAT ION S
◆◆
Gaurav Choudhary, M.D.
◆◆
◆◆
Aaron Simon, Elizabeth Harrington, GongXin Liu,
Gideon Koren, Gaurav Choudhary. Mechanism
of C-type Natriuretic Peptide-Induced Endothelial
Cell Hyperpolarization. American Journal
of Physiology - Lung Cellular and Molecular
Physiology. 2009 Feb;296(2):L248–56.
Gaurav Choudhary, Marcela Aliste, Peter Tieleman,
Robert J. French, Samuel C. Dudley. Docking
of Conotoxin GIIIA in Voltage-gated Sodium
Channel. Channels, 2007 Sep–Oct; 1(5):344–352
Qing Lu, D.V.M., Ph.D.
◆◆
Lu Q, Harrington EO, Newton J, Jankowich
M, and Rounds S. Inhibition of ICMT
induces endothelial cell apoptosis through
GRP94. American Journal of Respiratory Cell
and Molecular Biology, 37: 20–30, 2007.
◆◆
Lu Q (corresponding author). Transforming
growth factor-b1 protects against pulmonary
artery endothelial cell apoptosis via ALK5.
American Journal of Physiology Lung Cellular and
Molecular Physiology. 295, L123–L133, (2008).
◆◆
Lu Q (corresponding author), Patel B, Harrington
EO, and Rounds S. TGF-β1 causes pulmonary
microvascular endothelial cell apoptosis via ALK5.
American Journal of Physiology Lung Cellular and
Molecular Physiology. 296: L825–L838 (2009).
David Dosa, M.D.
◆◆
◆◆
Dosa DM, Dore DD, Mor V, Teno JM. Frequency
of Long-Acting Opioid Analgesic Initiation
in Opioid-Naive Nursing Home Residents. J
Pain Symptom Manage. 2009 (in press)
Dosa DM, Hyer K, Brown LM, Artenstein
AW, Polivka-West L, Mor V. The controversy
inherent in managing frail nursing home residents
during complex hurricane emergencies. J Am
Med Dir Assoc. 2008 Oct;9(8):599–604.
Stephen T. Mernoff, M.D.
◆◆
Elizabeth O. Harrington, Ph.D.
◆◆
Klinger, JR, Murray, JD, Casserly, B, Alvarez, DF,
King, JA, An, SS, Choudhary, G, Owusu-Sarfo, AN,
Warburton, R, Harrington, EO. (2007). Rottlerin
causes Pulmonary Edema in vivo: A Possible Role for
PKCd. Journal of Applied Physiology 103:2084–2094.
Matthew Jankowich, M.D.
◆◆
Jankowich M, Sameed YA, and Abu-Hijleh,
M. A 21-year-old man with fever and sore
throat rapidly progressive to hemoptysis and
respiratory failure. Chest 2007; 132: 1706–1709.
◆◆
Jankowich M., Polsky M., Klein M., and Rounds
S. “Heterogeneity in combined pulmonary fibrosis
and emphysema”. Respiration; 2008; 75: 411–417.
Albert Lo, Ph.D., M.D.
128
◆◆
Solleneck K, Lo AC (2008). Gait Kinematics
in Multiple Sclerosis Patients during Maximum
Velocity Walking Trials. Medicine and Science
in Sports and Exercise 40:5 Supplement.
◆◆
Lo AC (2008). Advancement of therapies
for neuroprotection in multiple sclerosis.
Expert Rev Neurother. 8:9 1355–1366.
Lo AC, Triche EW (2008). Cross-over trial
of body-weight supported treadmill training
with and without Robotic Assistance.
Neurorehabil Neural Repair 22:661–671.*
Mernoff, ST. Geriatric Neurorehabilitation in
the New Millenium. Rhode Island Medicine
and Health 91(5):149–51, May 2008.
Linda Nici, M.D.
◆◆
Nici, L, Limberg T, Hilling L, et al. Clinical
Competencies for Pulmonary Rehabilitation
Professionals. J Cardiopulm Rehab and
Prevention. 27(6):355–358, 2007.
◆◆
Nici,L. The major limitation to exercise performance
in COPD is inadequate energy supply to the
respiratory and locomotor muscles vs. lower limb
muscle dysfunction vs. dynamic hyperinflation.
Difficulties in determining the primary physiological
abnormality that limits exercise performance in
COPD. J Appl Physiol. 2008; 105(2):760–1.
◆◆
Nici, L, R ZuWallack, Rochester, C., Raskin,
J., et al. Pulmonary Rehabilitation: What we
know and what we need to know. J Cardiopulm
Rehab and Prevention. J Cardiopulm Rehab
and Prevention. 29(3): 141–151, 2009
a c a d e m i c y e a r s 20 08 a n d 20 09
Thomas P. O’Toole, M.D.
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Amal N. Trivedi, M.D., MPH
◆◆
O’Toole TP, Pollini RP, Grey P, Jones T, Bigelow G,
Ford DE. Factors identifying high and low frequency
health services utilization among substance using
adults. J Subst Abuse Treatment 2007; 33(1): 51–9.
◆◆
Trivedi AN, Zaslavsky AM, Schneider EC,
Ayanian JZ. Relationship between Quality of
Care and Racial Disparities within Medicare
Health Plans. JAMA. 2006;296:1998–2004.
◆◆
O’Toole TP, Pollini RP, Bigelow G, Ford DE. The
effect of substance abuse treatment on health
services utilization: bidirectional results from a
clinical trial. Med Care. 2007; 45(11):1110–5
◆◆
Trivedi AN, Rakowski W, Ayanian JZ. Effect
of Cost-sharing on Screening Mammography
in Medicare Health Plans. New England
Journal of Medicine 2008;358:375–83.
◆◆
O’Toole TP, Pollini RA, Ford DE, Bigelow
G. The health encounter as a treatable moment
for homeless substance-using adults: the role of
homelessness, health seeking behavior, readiness
for behavior change, and motivation for
treatment. Addict Behav. 2008; 33(9): 1239–43
◆◆
Trivedi AN, Swaminathan S, Mor V.
Insurance Parity and the Use of Outpatient
Mental Health Care Following a Psychiatric
Hospitalization. JAMA 2008;300;2879–2885.
Martin A. Weinstock, M.D., Ph.D.
◆◆
Christian J, Lapane KL, Hume AL, Eaton
CB, Weinstock MA. Association of ACE
inhibitors and angiotensin receptor blockers
with keratinocyte cancer prevention: VATTC
Trial. J Natl Cancer Inst 2008;100:1223–1232.
◆◆
Dore DD, Lapane KL, Trivedi M.D., Mor V,
Weinstock MA. Association between statin use and
risk of keratinocyte carcinomas in the Veterans
Affairs Topical Tretinoin Chemoprevention
Trial. Ann Intern Med 2009;150:9–18.
◆◆
Criscione VD, Weinstock MA, Naylor MF, Luque
C, Eide MJ, Bingham SF. Actinic keratoses: natural
history and risk of malignant transformation in
the VATTC Trial. Cancer 2009; 115:2523–2530.
Paul A. Pirraglia, M.D.
◆◆
◆◆
◆◆
Pirraglia PA, Taveira TH, Cohen LB, Wu W.
The moderating effect of depression diagnosis
on the effectiveness of a multi-factorial
cardiovascular risk reduction clinic. Preventing
Chronic Disease. 2008 Oct;5(4):A127.
Pirraglia PA, Taveira TH, Cohen LB, Dooley
A, Wu WC. Maintenance of cardiovascular
risk goals in veterans with diabetes after
discharge from a cardiovascular risk reduction
clinic. Preventive Cardiology 12:3–8, 2009.
Pirraglia PA, Biswas K, Kilbourne AM, Fenn H, Bauer
MS. A Prospective Study of the Impact of Comorbid
Medical Disease on Bipolar Disorder Outcomes.
Journal of Affective Disorders 115(3):355–9, 2009.
Wen-Chih Wu, M.D.
◆◆
Khatana SA, Taveira TH, Choudhary G, Eaton
CB, Wu WC. Change in Hemoglobin A1C and
C-Reactive Protein Levels in Patients with Diabetes
Mellitus. J Cardiometab Synd 2009;4:1–5.
◆◆
Wu WC, Schifftner TL, Henderson WG, Eaton CB,
Poses RM, Uttley G, Sharma SC, Vezeridis M, Khuri
SF, Friedmann PD. Preoperative hematocrit levels and
postoperative outcomes in older patients undergoing
noncardiac surgery. JAMA. 297:2481–8, 2007.
Kittichai Promrat, M.D.
◆◆
Mallette C, Flynn, M., Promrat, K. Outcome
of Screening for Hepatitis C Virus Infection
in the Veteran Population. American Journal
of Gastroenterology. 2008;103(1),131–137.
Sharon Rounds, M.D.
◆◆
Rounds, S. By invitation, Lu, Q, Harrington,
EO, Newton, J, Casserly, B. Pulmonary
endothelial cell signaling and function.
Transactions of the American Clinical and
Climatological Association. 119:155–169, 2008.
129
prov idence va medic a l cen t er
RE S EARCH
◆◆
HL64936 (Rounds)
“Small GTPases and Lung Endothelial Apoptosis”
NIH/ NHLBI
Period of Support: 4/2000–3/2010
Co-Investigator
Total costs: $3,048,000
◆◆
Merit Review (Rounds)
“RhoA GTPase Methylation and Vascular Permeability”
Department of Veterans Affairs
Period of Support: 10/2004–9/2007
Co-Investigator
Total costs: $408,300
◆◆
Predoctoral Award (Owusu-Sarfo)
“p190RhoGAP and PKCdelta: Investigation of their
role in endothelial barrier function”
American Heart Association, Northeast Affiliate
Period of Support: 7/2006–6/2008
Mentor
Total costs: $42,000
◆◆
1 F32 HL091664-01A1 (Grinnell)
“PKCd Modulation of Pulmonary Endothelial Barrier
Function via SHP2 and Src”
NIH/ NHLBI
Period of Support: 8/2008–7/2011
Mentor
Total costs: $147,750
◆◆
Career Development Award (Choudhary)
Role of C-type Natriuretic Peptide in Pulmonary
Vascular Function
Department of Veterans Affairs
Period of Support: 1/2007–12/2010
Mentor
Total costs: $150,000
Gaurav Choudhary, M.D.
BASIC
◆◆
◆◆
2008
Actelion Pharmaceuticals Young Investigator Award
Project: Role of Endothelin-Induced PKC delta
Activation in Right Ventricular Hypertrophy.
$75,000, Role: Principal Investigator
2007–2010
VA Career Development Award (VHA)
Project: Role of C-type Natriuretic Peptide in
Pulmonary Vascular Function.
$150,000, Role: Principal Investigator
David Dosa, M.D.
CLINICAL
◆◆
07-1146, California Health Care Foundation
8/22/07–10/31/09
“Reducing Potentially Preventable Transfers
at the End of Life”
Role: Co-PI
Peter Friedmann, M.D.
◆◆
The “Center on Systems, Outcomes and Quality in
Chronic Disease & Rehabilitation (SOQCR)”, a VA
Research Enhancement Award Program (REAP) in
health services research and development (HSR&D)
directed by Dr. Peter Friedmann, was funded from
10/01/08–09/30/12, with a budget of $356,000 per year.
Elizabeth O. Harrington, Ph.D.
BASIC
◆◆
◆◆
130
HL67795 (Harrington)
“Endothelial Barrier Function Modulation by PKCd"
NIH/ NHLBI
Period of Support: 8/2001–1/2012
Principal Investigator
Total costs: $2,955,750
Merit Review (Harrington)
"Signaling in Hypoxic Pulmonary vs. Systemic
Endothelium"
Department of Veterans Affairs
Period of Support: 7/2004–9/2007
Principal Investigator
Total costs: $450,000
Albert Lo, Ph.D., M.D.
VA Cooperative Study : Stroke Rehabilitation Clinical
Trials Phase II/III in Robotic Neurorehabilitation. To be
completed January 2010
◆◆
VA Equipment grants, $100,000
◆◆
VA Career Development Award, 2006–2010
Qing Lu, D.V.M., Ph.D.
BASIC
◆◆
TGFb and Pulmonary Hypertension
ATS/Pulmonary Hypertension Association Research
Grant
Duration of Support: 2008–09
Total Direct Costs: $100,000
Role: Principal Investigator
a c a d e m i c y e a r s 20 08 a n d 20 09
Linda Nici, M.D.
◆◆
CLINICAL
◆◆
A randomized, double-blind, double-dummy, parallel
group trial comparing 12 weeks treatment with
Tiotropium handihaler once daily to Combivent
M.D.I 2 actuations q.i.d. in COPD patients
currently prescribed Combivent M.D.I; BoerhingerIngelheim;2006–2007, principle investigator.
◆◆
VA Cooperative trial CSP #560- Bronchitis
and Emphysema Advice and Training
to Reduce Hospitalization (BREATH);
2008–2011. Site Investigator #650.
Thomas O’Toole, M.D.
◆◆
Engaging homeless veterans in primary care”
10/01/09–9/30/13 $710,900
VHA Health Services Research and Development
Service
PI: Thomas P. O’Toole, M.D.
◆◆
Reducing Ambulatory Sensitive Inpatient Admission
7/1/09–6/30/10 $25,000
VISN 1 Innovation Grants Award
P.I. Thomas P. O’Toole, M.D.
◆◆
Institute on Medicine as a Profession Physician
Advocacy initiative
7/1/08–6/30/11 $825,000
Institute on Medicine as a Profession at Columbia
University
National Program Co-Director:
Thomas P. O’Toole, M.D.
PI: VISN1 Innovation Grant, 2009–2010
Site PI: VA Health Services Research & Development,
Partners in Dementia Care, 2006–2010
◆◆
NHLBI RO1 64936-06
“Small GTPases and Lung Endothelial Apoptosis”
Principal Investigator: Sharon Rounds
Effort: 20% of Brown University Effort
Annual Direct Costs: $200,000 per year
Period of Support: 4/1/06–3/31/10
◆◆
NHLBI R25 HL088992
“Short-Term Training Program to Increase Diversity in
Health-Related Research”
Principal Investigator: Sharon Rounds
Effort: 5% of Brown University Effort
Annual Direct Costs: $90,000 per year
Period of Support: 6/1/07–3/31/12
◆◆
NHLBI T32 HL094300
“Cardiopulmonary Research Training”
Effort: 10% Brown Effort
Co-Training Director with Gideon Koren, M.D.
Annual Direct Costs: $570,727
Period of Support: 9/1/08–8/31/13
◆◆
VA Merit Review
“RhoA GTPase Methylation and Endothelial Cell
Function”
Principal Investigator: Sharon Rounds
Effort: 20% VA effort
Annual Direct Costs: $140,000 per year
Period of Support: 10/1/04–3/31/08
Kittichai Promrat, M.D.
CLINICAL
◆◆
Randomized, multi-center, Double-Blinded, Phase
IV study evaluating the efficacy (as measured by
sustained virological response) and safety of 360ug
induction dosing of Pegasys in combination with
Higher Copegus doses in treatment –naïve patients
with chronic Hepatitis C Genotype 1 virus infection
of high viral titer and baseline body weight greater
than or equal to 85kg
Role: Site principal investigator
Sponsor: Hoffman-La Roche.
*Phase 2 Randomized, Open label, multi-center,
therapeutic trial of the efficacy, immunogenicity,
and safety of GI-5005; an inactivated Recombinant
Saccharomyces cerevisiae expressing a hepatitis
C virus NS3-core fusion protein, combined with
pegylated interferon plus ribavirin standard of care
therapy versus standard of care alone, and GI-5005
salvage of standard of care failures, in patients with
hepatitis C
Role: Site Principal Investigator
Sponsor Globeimmune.
3/27/2008–
BASIC
CLINICAL
◆◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
Sharon Rounds, M.D.
Paul A. Pirraglia, M.D.
◆◆
◆
Amal N. Trivedi, M.D.
BASIC
◆◆
VA Health Services Research and Development,
Comparing the Quality and Equity of Care
in the VA and Medicare Managed Care,
10/08–9/13, Principal Investigator, $980,000
5/1/07–
131
prov idence va medic a l cen t er
◆◆
Robert Wood Johnson Foundation SHARE Program,
Evaluating the Implementation, Adoption and
Outcomes of Rhode Island’s HealthPact Plans,
4/08–10/09,Co-Principal Investigator, $200,000
◆◆
Transdisciplinary Cancer Control Research
Training Grant. National Cancer Institute
R25CA087972, 7/1/06–6/30/11, $2,458,852
direct, co-principal investigator.
◆◆
Pfizer Foundation, Effect of Cost Sharing on Preventive
Service Use and Health Outcomes among the
Elderly, 7/07–6/09, Principal Investigator, $130,000
◆◆
V A Keratinocyte Carcinoma Chemoprevention
(VAKCC) Trial. Department of Veterans
Affairs Cooperative Studies Program CSP #
562, 10/18/07–7/1/14 (end date approximate),
$9,680,930 (excludes investigators’ salary and
fringe), study chairman (principal investigator).
Martin A. Weinstock, M.D., Ph.D.
BASIC
◆◆
132
The Framingham School Nevus Study. National
Institute of Arthritis, Musculoskeletal and Skin
Disease R01AR49342, 9/1/03–8/31/08, $92,497 for
subcontract, principal investigator of subcontract.
◆◆
Efficacy of Web-based Training on Skin Cancer Triage.
National Cancer Institute R01CA106592, 6/16/04–
5/31/09, $1,620,044 direct, principal investigator.
◆◆
Indoor Tanning Use, DNA Repair and Risk
of Melanoma. National Cancer Institute
R01CA106807, 9/30/04–8/31/09, $62,013 direct for
subcontract, principal investigator of subcontract.
Wen-Chih Wu, M.D.
BASIC
◆◆
2005–2007 VA HSR&D “Variability in Surgical
Blood Transfusion Practices and Cardiovascular
Outcome” Merit Review: W. Wu, PI. $ 171,850 (25%)
◆◆
2006–2008 Daugherty Foundation “MultiTargeted Cardiac Risk Intervention in Type
2 Diabetes” W. Wu, PI. $ 50,000 (10%).
◆◆
2009–2010 VA HSR&D QUERI grant, “Variations
in Quality of Care and Outcomes for Veterans with
Heart Failure”, W. Wu, PI, Total Costs: $100,000
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
IN T ERNAT IONAL HEALT H AT ALPER T
M EDICAL S CHOOL OF B RO W N U NIVER S I T Y
I
nternational Health is an integral part of the Department of Medicine at The Warren Alpert Medical School of Brown University, and its affiliated
hospitals. Collaborative programs in Kenya, India, the
Dominican Republic, Cambodia, Ghana, the Philippines, and Indonesia have dedicated faculty members
who travel back and forth to each site and work closely
with partner faculty from the host institution. The
majority of these collaborations are bilateral. Residents,
students, and junior faculty, particularly from Kenya and
the Dominican Republic, visit and receive training at
Brown and likewise medical students, residents, fellows,
and faculty from Brown travel to these sites and teach
and participate in collaborative clinical projects. These
projects are supported both by the Department of Medicine and by the Medical School and through targeted
NIH funded grants through the Fogarty AIDS International Training and Research Program and the Center
for AIDS Research. Rotations at each of these sites are
available to residents, medical students, and fellows but
require considerable planning both in terms of effort and
time. The first step is to learn more about these programs
and to meet with the lead faculty members who have
developed these collaborations. For individuals who have
completed their residency and wish to focus two years
in international clinical research there is an NIH funded
training program which is available to provide support.
E l d o r e t, K e n ya
Faculty at the Warren Alpert Medical School at Brown
University began collaborating with faculty from the Moi
University School of Medicine in Eldoret, Kenya in 1977
as a medical exchange program to emphasize patient care,
teaching and research in medicine. As part of this collaboration, in recognition of the devastating HIV epidemic
sweeping across Africa, Moi, Indiana, Brown and other
collaborating Universities developed the AMPATH (Academic Model for the Prevention and Treatment of HIV)
Program. The AMPATH network has spread across western Kenya, now numbering 23 major treatment sites and
a cumulative enrollment of over 100,000 persons living
with AIDS. The pace of enrollment continues at 2,000
new patients per month. A model prevention strategy
of community based HIV testing and TB screening was
initiated in August of 2007. The AMPATH Program has
built upon the original structure to improve primary care
infrastructure (renamed the Academic Model Providing
Access to Heathcare). It has evolved into a model of comprehensive care encompassing clinical care, social service,
Brown and Kenyan colleagues on the grounds of Moi Teaching
and Referral Hospital
legal aid, food equity and economic empowerment
programs. It has been sited by the WHO and UNAIDS
and was nominated for the Nobel Peace Prize in 2007.
Funding comes from philanthropic donations, PEPFAR,
USAID as well as program-specific NGO grants.
Kenya is also one of the 22 high burden countries for
tuberculosis, the major cause of mortality for persons living with AIDS. Brown faculty lead the TB efforts at Moi,
developing innovative programs of active case finding,
prevention and treatment including the only community
based model for multidrug resistant TB in Kenya.
In the spring of 2009, the Riley Mother and Baby Hospital opened, anticipating 12,000 deliveries per year. The
facility has a 50 bed neonatal unit and is the referral and
training site for healthcare providers in obstetrics and
neonatal care in western Kenya
Brown faculty, residents and medical students regularly
participate in month long rotations on the inpatient
wards and ambulatory outpatient settings. During the
rotations, they reside in the student hostel or in dedicated
housing, a short walking distance from the medical center.
Federal and NGO funding has been secured by Brown
faculty in the areas of TB diagnostics, active TB casefinding, continually improving TB and HIV care, evaluation
of HIV drug resistance, HIV related malignancies such as
Kaposi’s sarcoma, lymphoma and cervical cancer screening. A Center of Excellence grant was recently awarded
that will support a number of cardiopulmonary initiatives.
The Program Director is E. Jane Carter, M.D.
For information contact:
Jane Carter (e_jane_cater@brown.edu) or
Janet O’Connell (jvoconnell@lifespan.org)
133
i n t e r n a t i o n a l h e a lt h
Chennai, India
Brown faculty, under the leadership of Drs. Kenneth
Mayer, Charles Carpenter, Susan Cu-Uvin, Rami Kantor
and Tim Flanigan, have collaborated with YRG Care
in Chennai, India for over ten years. YRG Care is the
largest community-based AIDS service organization in
India and currently cares for more than 13,000 people
living with HIV. YRG CARE is funded by the NIH
to conduct therapeutic and prevention research trials
through the HPTN and ACTG, and also has funding from NIDA to study substance use and the sexual
risk taking, as well as the natural history of HIV. YRG
CARE investigators have also been funded by the NIH
to conduct basic laboratory studies, and to develop lowcost clinical monitoring schema (e.g. CD4 and plasma
HIV RNA testing). YRG was the only Indian site for an
NIMH study to asses the impact of training community
opinion leaders to decrease HIV transmission, then, as
a result, was able to set up a state-of-the-art molecular
STD diagnostic laboratory. Opportunities to rotate on
the inpatient HIV service, outpatient HIV clinics, and
participate in clinical research projects are available. YRG
Care is a site for the NIH funded Fogarty International
Clinical Research Scholar and Fellows Program, with
the Miriam Hospital serving as the US collaborating site.
http://www.fogartyscholars.org/fellows/sites/india-mayer
This collaboration in Southern India also extends to the
Christian Medical College (CMC). CMC is a premier
academic medical center in Southern India which has
great expertise in a myriad of infectious diseases from
tetanus to leprosy to TB to HIV and AIDS. They are
widely recognized as a leader in HIV medical education in Southeast Asia. Opportunities to rotate on the
inpatient and outpatient at CMC are available. CMC
is also a site for the NIH funded Fogarty International Clinical Research Scholar and Fellows Program.
http://www.fogartyscholars.org/fellows/sites/india-tufts
Another excellent opportunity is at the Indian Council
of Medical Research’s TB Research Center in Chennai. Opportunities there include working with clinical
researchers studying the optimal management of HIV
and TB co-infection and HIV vaccine trials, as well as
lab work in pharmacology, virology and immunology.
For information on collaborative projects in Southern
India please contact:
Ken Mayer (kenneth_mayer@brown.edu)
Eileen Caffrey (e_caffrey@lifespan.org)
134
Ken Mayer and Fogarty trainees (left to right - Drs. M. Muniyandi TRC,
Chennai, India, Ken Mayer, Anand Manoharan, CMC, Vellore, India,
Nurlan Silitonga, Indonesia, Geetha Ramachandran, TB Research
Center, Chennai, India
Accr a , G h a n a
Brown faculty members under the leadership of Dr Awe
Kwara have collaborated with colleagues at the University
of Ghana Medical School and the Korle-Bu Teaching
Hospital in Accra. Ongoing work has focused on the
pharmacokinetics and pharmcogenetics of HIV therapy
in TB co-infected patients, virologic responses to HAART
in TB co-infected patients and evaluation of tuberculosis
drug resistance. The Korle-Bu Teaching Hospital is a large
tertiary center and the main teaching hospital for several
schools under the College of Health Sciences. These
include the schools of medicine, pharmacy, dental, nursing and allied health sciences. The University of Ghana
College of Health Sciences and Brown University have
been awarded a planning grant from Higher Education
Development (HED)/USAID to plan a major initiative
to twin the strengths of the universities to strengthen the
response to HIV/AIDS in Ghana and West Africa. This
initiative will develop excellence in HIV/AIDS education,
continuous professional development and strengthen
collaborative research between the two institutions. The
Korle-Bu Teaching Hospital is also a collaborating site for
the West African Network of Excellence for TB, AIDS
and Malaria (WANETAM) clinical trials. In addition to
collaborative research projects, there are opportunities for
fellows, resident, medical students to rotate on the wards,
inpatient and outpatient HIV and TB services.
For information on collaborative projects or
clinical rotations please contact: Awewura Kwara
(akwara@lifespan.org).
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
C a mb o d i a
Brown medical school faculty have collaborated with
physician researchers in Phnom Penh at Sihanouk Hospital Center of HOPE, the National Pediatric Hospital,
and the National Center for HIV/AIDS, Dermatology
and STD, and in Siem Reap at the Angkor Hospital
for Children for over ten years. The NIH Fogarty
AITRP program has helped support this collaboration
and brought over faculty from Cambodia to develop
advanced expertise in HIV medicine. Collaborative
projects are then developed with these faculty members
at different sites in Cambodia. These projects include
an HIV women’s clinic, HIV/TB care, follow-up and
management of HIV-exposed and infected children
and nutritional complications related to HIV and
AIDS in Cambodia.
Dr. Sam Sophan, Fogarty trainee, National Pediatric Hospital,
Cambodia, presenting at IAS, Sydney Australia, Aug 07
Interested individuals should contact:
Ken Mayer (kenneth_mayer@brown.edu)
Philippines
Collaborations in the Philippines are focused both on
parasitology (schistosomiasis, polyparasitism) as well
as HIV prevention and HIV therapy. Susan Cu-Uvin,
Steve Opal, Jennifer Friedman and Jake Kurtis have all
collaborated in the Philippines for over ten years. Collaborative projects exist “in the field” as well in Manila,
in collaboration with the University of Philippines
and with the Research Institute of Tropical Medicine
(RITM) and the Department of Health. These collaborations largely focus on specific projects developed by
faculty. Opportunities to rotate at the inpatient wards
and outpatient clinics in the Philippine General Hospital (University of the Philippines) are available.
For more information contact:
Susan Cu-Uvin (scu_uvin@lifespan.org)
Steve Opal (steven_opal@brown.edu)
Jake Kurtis (jonathan_kurtis@brown.edu)
Jennifer Friedman (Jennifer_friedman@brown.edu)
Indonesia
The Fogarty AIDS program has supported faculty members from Indonesia since 1993. Collaborative projects
have been developed in Bali, in Yogyakarta and in
Jakarta. Opportunities exist to participate in focused research projects with faculty at those institutions, ranging
from prevention interventions for sex workers and IDUs
in Bali, to training doctors in AIDS care in Jakarta.
Interested individuals should contact:
Kenneth Mayer (Kenneth_Mayer@brown.edu)
A number of faculty have developed internationally recognized expertise in international health and are happy
to mentor medical students, residents, and fellows in
this arena. These faculty welcome inquiries and are
happy to provide support. They include:
Charles Carpenter (ccjc@lifespan.org)
Kenneth Mayer (kenneth_mayer@brown.edu)
Tim Flanigan (tflanigan@lifespan.org)
Susan Cu-Uvin (scu-uvin@lifespan.org)
Joseph Diaz (joseph_diaz@brown.edu)
Mike Stein (Michael_Stein@brown.edu)
Jake Kurtis (jonathan_kurtis@brown.edu)
Jane Carter (e_jane_carter@brown.edu)
Rami Kantor (rkantor@brown.edu)
Awewura Kwara (akwara@lifespan.org)
The international health collaborations through the
Department of Medicine provide an ideal opportunity
to expand clinical skills as well as participate in international collaborative projects.
Patients arrving at the clinic at A Mother’s Wish.
135
i n t e r n a t i o n a l h e a lt h
D e pa r tm e n t
of Medicine
E xc h a n g e Pr o g r a m i n
t h e D o m i n i c a n R e p ub l i c
During the academic year 2007–2009, the Brown
Department of Medicine Program in the Dominican
Republic continued its activities in the areas of education, patient care and research.
Teams of Brown medical students, internal medicine
residents and Department of Medicine faculty traveled
to Cabral y Baez Hospital in Santiago, DR during the
months of October and February. A total of 13 medical
students, 6 residents and 9 internal medicine faculty
participated in the elective during these 2 years. While
in Santiago, the teams participate in the teaching activities of the Department of Medicine at Cabral y Baez
Hospital, including morning report, ward rounds, noon
conference, outpatient clinics including HIV clinic,
and emergency room rounds. The teams also work in a
community-based primary care clinic outside of Santiago, run by a non-profit organization called A Mother’s
Wish. The clinical work at A Mother’s Wish includes
seeing scheduled adult primary care patients, conducting group patient education sessions and making home
visits to elderly patients unable to get to the clinic.
Ten Cabral y Baez internal medicine residents traveled
to Brown to participate in the activities of our internal
medicine residency program. They participated in our
morning report, presenting cases from their hospital as
“unknowns” for our residents. They went on ICU rounds,
attended primary care, HIV and subspecialty clinics, and rounded with subspecialty consult teams. The
residents from the Cabral program who have rotated
through the Brown hospitals have been a tremendously
136
A patient on a hospital ward in the Dominican Republic sleeps under
mosquito netting for protection from mosquito-borne illnesses.
helpful resource for our visitors working at Cabral.
In the 2007, the director of the internal medicine training program at Cabaral y Baez, Dr. Francisco Mejia
Ortiz visited the Brown internal medicine program to
learn about the structure and educational methods of
our program. In addition, the director of the Cabral
HIV treatment program, Dr. Claudia Rodriguez, visited
Brown’s HIV programs.
With support from the Department of Medicine, the
HIV treatment program at Cabral y Baez, Clinica De Infermadades De Danos Inmunologico (CEDI) has grown
steadily, and currently more than 1000 patients are
being followed by CEDI. With the assistance of medical
students George Aghia and Micah Johnson, CEDI has
maintained an electronic database of all of its patients.
The plan for 2009–2010 is to continue sending Brown
teams to Cabral for 2 months/year. Additional internal
medicine faculty is being recruited to participate. We will
continue to host four Cabral y Baez residents per year.
a c a d e m i c y e a r s 20 08 a n d 20 09
◆
j u ly 1 , 20 07 – j u n e 30 , 20 09
D e pa r tm e n t o f M e d i c i n e
Selected Gr an d Roun ds
09/18/07
“Umbilical Cord Blood Transplantation in Adults”, Karen K. Ballen, M.D., Associate Professor of Medicine,
Harvard Medical School
10/02/07
The Fourth Annual Paul Calabresi Memorial Lecture – “Advances in Our Understanding and Treatment of
Prostate Cancer”, Philip W. Kantoff, M.D., Professor of Medicine, Harvard Medical School
10/16/07
The Kameny Lecture – “Meeting the Challenge of Multi-Morbidity”, Charles E. Boult, M.D., MPH, MBA,
Professor and Director, Lipitz Center for Integrated Health Care, Department of Health Policy and
Management, Bloomberg School of Public Health, Johns Hopkins University
11/20/07
“Fifty Years After Steroids: Advances in Rheumatoid Arthritis”, Michael E. Weinblatt, M.D., John R.
Riedman Professor of Medicine, Harvard Medical School
12/11/07
“The Rising Tide of Arterial Stiffness-Related Disorders”, Gary F. Mitchell, M.D., President, Cardiovascular
Engineering, Inc., Waltham, MA
01/08/08
“Antibiotic Stewardship”, Neil O. Fishman, M.D., Associate Professor of Medicine, University of
Pennsylvania School of Medicine
01/29/08
“The Patient-Centered Medical Home: A Potential Model for Health Care Redesign & Payment Reform”,
Michael S. Barr, M.D., MBA, FACP, Vice President, Practice Advocacy & Improvement, Division of
Governmental Affairs & Public Policy, American College of Physicians
02/5/08 “Guilty, Afraid, and Alone: Patient, Family and Clinician Experiences with Medical Error”, Tom Delbanco,
M.D., Richard and Florence Koplow-James Tullis Professor of General Medicine and Primary Care,
Harvard Medical School
137
gr and rounds
03/11/08
“Why Do Hypertensive Kidneys Fail?”, Christopher S. Wilcox, M.D., Ph.D., George E. Schreiner Professor
of Nephrology, Georgetown University
03/18/08
“Idiopathic Inflammatory Myopathy”, Chester V. Oddis, M.D., Professor of Medicine, University of
Pittsburgh School of Medicine
04/01/08 “Cigarette Smoking and Progression of Type 2 Diabetic Nephropathy”, Donald E. Wesson, M.D., FACP, Vice
Dean, Texas A&M University College of Medicine, Chief Academic Officer, Scott and White Clinic and
Hospital, Temple, Texas
05/06/08 The Beckwith Visiting Professorship Lecture – “Top Stories in Infectious Disease 2007–2008”, Robert C.
Moellering, Jr., M.D., Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical
School
Presentation of the 7th Annual Warren Alpert Medical School of Brown University, Department of
Medicine Beckwith Family Awards for Outstanding Teaching
06/03/08 “Evidence Based Management of Aortic Valve Disease”, Robert O. Bonow, M.D., Goldberg Distinguished
Professor of Cardiology, Northwestern University Feinberg School of Medicine
06/10/08
“The Anion Gap Metabolic Acidoses – Anything New?”, Michael Emmet, M.D., MACP, Chairman,
Department of Internal Medicine, Baylor University Medical Center, Clinical Professor of Medicine,
University of Texas Southwestern Medical Center
06/24/08 “High Altitude Medical Problems”, Lawrence C. Mohr, M.D., FACP, FCCP, Professor of Medicine,
Biometry & Epidemiology, Medical University of South Carolina
07/29/08 “Creating the Culture of Quality in an Academic Department of Medicine”, Mark L. Zeidel, M.D., Chair,
Department of Medicine, Beth Israel Deaconess Medical Center, Herrman L. Blumgart Professor of
Medicine, Harvard Medical School
09/16/08
“Lung Transplantation – What Internists Should Know?”, Atul C. Mehta, M.B., B.S., Vice-Chairman,
Department of Pulmonary & Critical Care Medicine, Head, Section of Bronchology, Medical Director,
Lung Transplantation, Transplant Center, Cleveland Clinic Foundation
09/23/08 “TB, HIV and Extensively Resistant (XDR) TB: Triple Trouble”, Gerald H. Friedland, M.D., Professor of
Medicine and Professor of Epidemiology and Public Health, Yale University School of Medicine
138
10/21/08
Hospital-Wide Grand Rounds – “Getting Hospital Infections to Zero and Other Possible Dreams”, Donald A.
Goldmann, M.D., Professor of Pediatrics, Harvard Medical School, Professor of Immunology and Infectious
Diseases, Harvard School of Public Health, Knowles Scholar, Harvard College
11/11/08
Experiences from Brown’s Sister Renal Center in China – “Nephrology in China: Experience from the
Nanjing Research Institute of Nephrology”, Zhi-Hon Liu, M.D., Professor of Medicine, Nanjing University
School of Medicine, P R China
“Multi-target Immuno-therapy of Severe Lupus Nephritis”, Lei-Shi Li, M.D., Vice Dean, Professor of
Medicine, Nanjing University School of Medicine, P R China
10/18/08
“Update on SLE”, Michelle Petri, M.D., MPH, Professor of Medicine, Johns Hopkins University School
of Medicine
01/27/09
The Kameny Lecture – “Listen to Your Patients: They Are Telling You How to Improve the Quality of
Transitional Care”, Eric A. Coleman, M.D., MPH, Professor of Medicine with Tenure, Divisions of
Health Care Policy and Research, and Geriatric Medicine, University of Colorado at Denver Health
Sciences Center
a c a d e m i c y e a r s 20 08 a n d 20 09
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j u ly 1 , 20 07 – j u n e 30 , 20 09
03/03/09 “Advances in CLL”, Kanti R. Rai, M.D., Professor of Medicine, Albert Einstein College of Medicine
03/17/09
“Ending the AIDS Epidemic: The search for an AIDS vaccine”, Seth F. Berkley, M.D., Adjunct Professor of
Medicine, The Warren Alpert Medical School of Brown University and New York University, Adjunct
Professor of Public Health, Columbia University
03/24/09 “The Medicine in Seinfeld: An Evidence Based Appraisal”, Mark S. Lachs, M.D., MPH, Irene F. and I. Roy
Psaty Distinguished Professor of Medicine, Professor of Medicine (with tenure), Weill Medical College of
Cornell University
03/31/09
General Internal Medicine Update – “Long-term Opioid Use in Chronic Non-malignant Pain”, Michael S.
Picchioni, M.D., Assistant Professor of Medicine, Tufts University School of Medicine
05/05/09 The Beckwith Visiting Professorship Lecture – “Consequences (Expected and Otherwise) of the Quality
and IT Revolutions”, Robert M. Wachter, M.D., Lynnne and Marc Benioff Endowed Chair in Hospital
Medicine, University of California, San Francisco
Presentation of the 8th Annual Warren Alpert Medical School of Brown University, Department of
Medicine Beckwith Family Awards for Outstanding Teaching
06/09/09 The Grace McLeod Rego Memorial Lecture – “Evidence Based Medicine versus Humanism: A Straw
Choice”, David Gary Smith, M.D., FACP, Clinical Associate Professor of Medicine, Temple University
Medical School
Grand Rounds Lecture
139
clinical activit y
CLINICAL AC T IVI T Y
Seven Year Period Including: FY 2002, FY 2003, FY 2004, FY 2005, FY 2006, FY 2007, FY 2008
RHODE ISLAND HOSPITAL
FY 02
10/01–9/02
FY 03
10/02–9/03
FY 04
10/03–9/04
FY05
10/04–9/05
FY06
FY07
10/05–09/06 10/06–9/07
FY08
10/07–09/08
Inpatient
Admissions/
Discharges
13,477
12,725
12,983
14,503
15,205
15,796
14,450
Outpatient Volume
132,793
133,302
145,259
134,078
149,491
142,320
145,333
FY 02
10/01–9/02
FY 03
10/02–9/03
FY 04
10/03–9/04
FY05
10/04–9/05
FY06
10/05–9/06
FY07
10/06–9/07
FY08
10/07–9/08
Inpatient
Admissions/
Discharges
8,273
8,383
9,004
9,566
9,038
9,726
10,806
Outpatient Volume
81,775
95,297
121,184
134,856
131,960
137,099
141,290
THE MIRIAM HOSPITAL
MEMORIAL HOSPITAL OF RHODE ISLAND
FY 02
10/01–9/02
FY 03
10/02–9/03
FY 04
10/03–9/04
AY 05
07/05–6/06
AY 06
FY07
07/06–06/07 10/06–9/07
FY08
10/07–09/08
Inpatient
Admissions/
Discharges
7698
7703
7888
7169
7510
7270–7253
7029–7048
Ambulatory Visits
41,197
40,314
42,633
34,755
32,250
64,862
67,808
PROVIDENCE VETERANS ADMINISTRATION MEDICAL CENTER
140
FY 02
10/01–9/02
FY 03
10/02–9/03
FY 04
10/03–9/04
FY05
10/04–9/05
FY06
FY07
10/05–09/06 10/06–9/07
FY08
10/07–09/08
Admissions
1779
1988
2674
2184
2028
2091
2176
Discharges
1698
1899
2650
2105
1921
1949
2112
Ambulatory Visits
92,681
93,602
97,653
101690
101,785
100,538
104,157
a c a d e m i c y e a r s 20 08 a n d 20 09
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j u ly 1 , 20 07 – j u n e 30 , 20 09
RE S EARCH OVERVIE W
B
rown University has long been regarded as a
leader in all aspects of health care and teaching, including research. Over the past 10 years,
research funding within the Department of Medicine
at Rhode Island Hospital, Memorial Hospital of Rhode
Island, Veterans Administration-Providence and The
Miriam Hospital grew from $9.9 million in 1997 to over
$39 million in 2009 – almost a 400% increase over that
period. Over 75% of current funding comes from federal
programs such as NIH, HRSA, CDC, and HHS.
The major research laboratories, animal facilities and
centers at Brown are located among all the affiliates with
Rhode Island Hospital accounting for the majority (68%
of overall Department of Medicine funding). These
laboratories are highlighted by the Galletti Research
Building, a 60,000+ square foot research facility, which
houses the Liver Research Center, Diabetes and Endocrinology Research Center, and Infectious Disease
laboratories as well as the Coro research facility which
houses the Diabetes Hallet Center, Genomics and
Proteomics Center, and Cardiovascular Research Center.
Construction has also begun of new research space in
the Coro facility to buiuld a new 10,000 square foot
Medical Oncology research laboratory.
Both basic and clinical research are well represented in
the Department. For basic research, major strengths
include the Liver Research Center (directed by Dr. Jack
Wands), Diabetes and Endocrinology Research Center
(directed by Dr. Robert Smith), and Medical Oncology
and Stem Cell Research (directed by Dr. Peter Quesenberry). Notably, in 2009 Rhode Island Hospital received
two NIH funded COBRE grants totaling $22 million
over 5 years for the Proteomics and Genomics Research
Program (Dr. Douglas Hixson, Principal Investigator)
and Stem Cell Biology Programs (Dr. Peter Quesenberry, Principal Investigator).
Clinical Research strengths include the Infectious
Disease program under Dr. Timothy Flanigan, which
has a major program in both domestic and international
HIV/AIDS (including an NIH funded Center for AIDS
Research program and T-32 Training grant from NIH,
and Fogarty International program), Research Section,
General Internal Medicine, under Dr. Peter Friedmann
and the Cardiology research groups under Drs. J. Dawn
Abbott, James Arrighi and Barry Sharaf, (Interventional
Cardiology) and Dr. Alfred Buxton (Electrophysiology).
At Memorial Hospital, Dr. Andrew Artenstein has
received significant federal funding for a “Center for Biodefense”. In 2009, Dr. Michael Stein has initiated a Substance Abuse Research Program based at Butler Hospital.
With ongoing recruitments for both senior and junior
faculty, increasing successes of our existing faculty, research for the Department of Medicine should continue
to grow and become even stronger in the future.
r eS e a r c h g r oW T h f y0 0 – f y0 9
$45,000,000
Butler
$40,000,000
MEM
VA
Total Expenses
$35,000,000
RIH
$30,000,000
TMH
$25,000,000
$20,000,000
$15,000,000
$10,000,000
$5,000,000
$0
FY00
FY01
FY02
FY03
FY04
FY05
FY06
FY07
FY08
FY09
Fiscal Year
141
a f f i l i a t e d h o s p i ta l s
W
hen it comes to clinical experience, the
Warren Alpert Medical School of Brown
University offers an enviable experience.
It is Rhode Island’s only school of medicine and
home to a community of scholars and physicians
dedicated to the highest standards in education,
research and health care.
Since 1975, when it conferred its first medical
degrees, the School has had two major goals for its
graduates: that they be broadly and liberally educated men and women, and that they view medicine as
a socially responsible human service profession.
Alpert Medical School’s seven affiliated hospitals serve
one and a half million people of diverse backgrounds
and socioeconomic status, all within a fifteen-minute
drive of the Brown campus on College Hill.
142
The road to becoming a physician or scientist
at Alpert Medical School takes students to these
hospitals as well as to countless other clinical sites,
such as community practices throughout the state,
inner city clinics, biotech companies and to our international health programs throughout the world. These sites provide a range of diverse training opportunities for medical students and residents.
Alpert Medical School and its hospital partners
are the anchors of Rhode Island’s academic
medical center.
a c a d e m i c y e a r s 20 08 a n d 20 09
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j u ly 1 , 20 07 – j u n e 30 , 20 09
AFFLIAT ED HO S PI TAL S
R h o d e Is l a n d H o s p i ta l
Rhode Island Hospital is a private, 719-bed, not-forprofit Level 1 trauma center, and a major teaching
hospital of The Warren Alpert Medical School of Brown
University. Founded in 1863, Rhode Island Hospital is
the largest hospital in Rhode Island, and the third largest in New England. The hospital provides a full range
of diagnostic and therapeutic services to patients, with
particular expertise in cardiology, oncology/radiation
oncology, orthopedics, diabetes, neuroscience, pediatrics
and emergency medicine/trauma. Its pediatric division, Hasbro Children’s Hospital, is the only dedicated
pediatric facility in the state. The hospital ranks among
the country’s leading independent hospitals that receive
funding from the National Institutes of Health (NIH),
with NIH awards of nearly $29 million annually.
T h e M i r i a m H o s p i ta l
The Miriam Hospital is a private, 247-bed, not-for-profit, acute care general hospital founded by Rhode Island’s
Jewish community in 1926. It is a major teaching hospital for The Warren Alpert Medical School of Brown
University. The Miriam Hospital provides a broad range
of primary, secondary and tertiary medical services
to adolescents and adults in 34 medical and surgical
specialties and subspecialties, with particular expertise
in cardiology, oncology, orthopedics, gastroenterology,
urology and AIDS/HIV care.
T h e M e m o r i a l H o s p i ta l
o f R h o d e Is l a n d
The Memorial Hospital of Rhode Island is a 294-bed
hospital that serves a community of more than 180,000
people in Pawtucket and the Blackstone Valley region of
Rhode Island. Memorial’s rehabilitation center focuses
on services to patients afflicted by stroke, amputation,
or neurological disability and includes comprehensive
inpatient and outpatient services. The hospital offers
cutting-edge cancer care and is the practice base for the
Brown residency program in family medicine.
143
a f f i l i a t e d h o s p i ta l s
The Providence
VA M e d i c a l C e n t e r
The Providence VA Medical Center provides high quality comprehensive outpatient and inpatient health care
to veterans residing in Rhode Island and southeastern
Massachusetts. Each veteran who comes to the Medical
Center for care is assured personalized care by a team of
health care providers. A primary care provider coordinates each patient’s medical care, patient education
needs and referrals to any of the Medical Centers’ 32
sub-specialty clinics. The Medical Center’s Ambulatory
Care Program is supported by a general medical and
surgical inpatient facility that delivers a broad range of
services in medicine, surgery, and behavioral sciences.
W o m e n a n d I n f a n ts
H o s p i ta l
Women & Infants Hospital of Rhode Island, a Care
New England Hospital and one of the nation’s leading
specialty hospitals for women and newborns, offers 167
adult beds (45 medical/surgical and 122 obstetrics) and
140 infant bassinets. The primary teaching affiliate of
The Warren Alpert Medical School of Brown University for obstetrics, gynecology and newborn pediatrics,
Women & Infants is the seventh largest obstetrical
service in the country with more than 9,000 deliveries per year. In 2009, Women & Infants opened the
country’s largest single-family room neonatal intensive
care unit. Women & Infants has been designated a
Breast Center of Excellence by the American College
of Radiography; a Center for In Vitro Maturation
Excellence by SAGE In Vitro Fertilization; a Center
of Biomedical Research Excellence by the National
Institutes of Health; and a Neonatal Resource Services
Center of Excellence. It is one of the largest and most
prestigious research facilities in high-risk and normal
obstetrics, gynecology and newborn pediatrics in the
nation, and is a member of the National Cancer Institute’s Gynecologic Oncology Group. The hospital was
named a National Center of Excellence in Women’s
Health by the federal government.
The Alpert Medical School is also affiliated with The Emma Pendelton Bradley Hospital and Butler Hospital, its associated
psychiatric facilities.
144
B r o w n U n i v e r s i t y, P r o v i d e n c e ,
and New England
January 2011 The Warren Alpert Medical School of Brown University
Editor
Tricia Meehan
Design
Brian Prosnitz
Brown University Graphic Services
Photography
Constance Brown
Lucas Foglia
Scott Kinsley
Rob Pike
Len Rubenstein
Women & Infant’s Hospital Media Center
Special thanks to the following
for their contributions:
Dora Bethel, Sandy Bibby, Barbara Bottone, Dan Bryant, Denise Carbone, Sharon Chiott,
Jane Conti-Dutko, Maria DaRocha, Faye Hall, Doreen Hoogasian, Jenna Houle, Lucy Kwiek,
Denise Lavely-O’Hara, Margaret Malo, Kathy Poland, and Charleen Pysz
B
rown University and Providence, Rhode
Island together provide a pleasant and
interesting setting for study, recreation,
and daily life. From atop College Hill the
University overlooks downtown Providence, the
capital of Rhode Island and the second largest
city in New England. The University was founded
in 1764. Its architecturally diverse buildings and
quadrangles center on the original College Green.
In the surrounding residential area are houses that
date back to colonial times, together with various
historic sites, including the Old State House,
where independence in America was first declared
and the First Baptist Meeting House, the oldest
Baptist Church in America.
Contemporary life in Providence complements
the city’s interesting history. One can walk from
the campus to a variety of restaurants, to the
nationally renowned Trinity Square Repertory or
to a jazz club or dance performance. Attractions
also include several art galleries, including the
Rhode Island School of Design Museum of Art.
On the Brown campus are plays, concerts, movies,
lectures, art exhibits, and many other sources
of entertainment and intellectual stimulation
throughout the year. A modern athletic complex
within easy walking distance from the main
campus offers swimming in a modern Olympicsized pool, externsive exercise equipment, squash
and tennis courts, and ice-skating, as well as
playing fields and facilities for intramural and
varsity team sports.
Rhode Island is especially known for recreational
opportunities centered on the ocean and
Narragansett Bay, including boating, fishing,
sailing, and swimming. Newport, the site of some
of the nation’s most magnificent mansions and
for many years home of the America’s Cup sailing
races, is less than an hour away. Providence is an
hour by car, bus or train from Boston, an hour
from Cape Cod, about three hours from major
New Hampshire and Vermont ski areas, and three
and a half hours from New York City. At the
T.F. Green Airport, ten minutes from downtown
Providence, several major airlines offer frequent
service to all major points in the United States.
D e pa r t m e n t o f M e d i c i n e
T h e Wa r r e n A l per t M e d i ca l S c h o o l o f B r ow n U n i v er s i t y
De pa r t m e n t o f M edicin e
Academic Years 2008 and 2009
A ca d e mic Y e ar s 2 0 0 8 a n d 2 0 0 9
◆
The Warren Alpert Medical School of
Brown University Department of Medicine
Administrative Offices
Rhode Island Hospital
Main Building, 1st Floor
593 Eddy Street
Providence, RI 02903
j u ly 1, 2 0 0 7– J u n e 3 0 , 2 0 0 9
Rhode Island Hospital/Hasbro Children’s Hospital
The Miriam Hospital
Memorial Hospital of Rhode Island
Women & Infant’s Hospital
Veteran’s Administration Medical Center
Patient Care,
Teaching & Research
Rhode Island Hospital/Hasbro Children’s Hospital
The Miriam Hospital
Memorial Hospital of Rhode Island
Women & Infant’s Hospital
WWW.BROWNMEDICINE.ORG
Veteran’s Administration Medical Center
◆
j u ly 1, 2 0 0 7– J u n e 3 0 , 2 0 0 9