Menopause
The Journal of The North American Menopause Society
VOLUME 23, ISSUE 3, 2016
Supplemental Digital Content is available.
CONTENTS
In Memoriam
233
Thomas B. Clarkson Jr, DVM (June 13, 1931–December 1, 2015)
Editorials
235
Is vaginal administration the ‘‘way out’’ of the hormone of controversy?
Andrea R. Genazzani, MD, PhD, and Nicola Pluchino, MD, PhD
236
Hormonal-stress interactions in precipitating perimenopausal depressive
symptoms
Barbara L. Parry, MD
239
Association between vitamin D and falls in young postmenopausal women
Santiago Palacios, PhD
241
Resident education in menopause: why it is important and how we can best
achieve it
Holly R. Khachadoorian-Elia, MD, MBA
Original Articles
243
Efficacy of intravaginal dehydroepiandrosterone (DHEA) on moderate to severe
dyspareunia and vaginal dryness, symptoms of vulvovaginal atrophy, and of the
genitourinary syndrome of menopause
Fernand Labrie, MD, PhD, David F. Archer, MD, William Koltun, MD, Andrée Vachon, MD,
Douglas Young, MD, Louise Frenette, MD, David Portman, MD, Marlene Montesino, MD,
Isabelle Côté, BSc, Julie Parent, PhD, Lyne Lavoie, MSc, Adam Beauregard, BSc, MBA,
Céline Martel, PhD, Mario Vaillancourt, BSc, MBA, John Balser, PhD,
Érick Moyneur, BSc, MA, and the members of the VVA Prasterone Research Group
Daily intravaginal administration of 0.50% (6.5 mg) dehydroepiandrosterone (DHEA,
prasterone) is in line with the absence of significant drug-related adverse events.
(continued)
Menopause: The Journal of The North American Menopause Society (ISSN 1072-3714) is published monthly for The North American Menopause
Society by Lippincott Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740-2116. Business and production offices are located
at Two Commerce Square, 2001 Market St., Philadelphia, PA 19103. All rights reserved. Printed on acid-free paper. Periodical postage paid at
Hagerstown, Maryland, and at additional mailing offices. Copyright © 2016 by The North American Menopause Society.
POSTMASTER: Send address changes to Menopause: The Journal of The North American Menopause Society, P.O. Box 1550, Hagerstown, MD
21740.
CONTENTS
(continued)
257
Estradiol variability, stressful life events, and the emergence of depressive symptomatology
during the menopausal transition
Jennifer L. Gordon, PhD, David R. Rubinow, MD, Tory A. Eisenlohr-Moul, PhD,
Jane Leserman, PhD, and Susan S. Girdler, PhD
Estradiol variability may enhance emotional sensitivity to psychosocial stress, particularly
sensitivity to social rejection.
267
Effect of isolated vitamin D supplementation on the rate of falls and postural balance in
postmenopausal women fallers: a randomized, double-blind, placebo-controlled trial
Luciana Mendes Cangussu, MSc, Jorge Nahas-Neto, MD, PhD, Claudio Lera Orsatti, PhD,
Priscila Ferreira Poloni, MD, Eneida Boteon Schmitt, MD, Benedito Almeida-Filho, MD,
and Eliana Aguiar Petri Nahas, MD, PhD
Isolated vitamin D supplementation for nine months resulted in a lower incidence of falls and
improvement in postural balance.
275
Effectiveness of a 2-year menopause medicine curriculum for obstetrics and
gynecology residents
Mindy S. Christianson, MD, Chantel I. Washington, MD, Katherine I. Stewart, MD, MBA,
and Wen Shen, MD, MPH
A 2-year menopause medicine curriculum for OB/GYN residents is an effective modality to
improve resident knowledge required to manage menopause.
280
Bone structure and turnover in postmenopausal women with type 2 diabetes mellitus
Farideh Razi, MD, Mahnaz Esmaili, MS, Ensieh Nasli Esfahani, MD,
Parichehreh Yaghmaei, PhD, Mostafa Qorbani, MD, Zahra Mohammadi, MS,
Abbasali Keshtkar, MD, Patricia Khashayar, MD, and Bagher Larijani, MD
In this study there was no difference in bone mass values or bone turnover process between
Iranian postmenopausal women with or without diabetes.
286
Physical therapy for urinary incontinence in postmenopausal women with osteoporosis or
low bone density: a randomized controlled trial
Meena Sran, PT, PhD, Joanie Mercier, PT, MSc, Penny Wilson, BSR, Pat Lieblich, BPT,
and Chantale Dumoulin, PT, PhD
Incontinence in older women with osteoporosis can be effectively treated by physical therapy.
Given the negative impact of urinary incontinence on physical activity levels and the importance
of physical activity to improving bone density, these results should be used to educate women
with osteoporosis and urinary incontinence.
294
Comparative efficacy and safety of estradiol transdermal preparations for the treatment of
vasomotor symptoms in postmenopausal women: an indirect comparison meta-analysis
Christine Derzko, MD, FRCSC, Martin Sergerie, PhD, DESS, Gaye Siliman, MSc,
Mark Alberton, MSc, and Kristian Thorlund, PhD, MSc
In this study the efficacy of Divigel 0.25 mg, as measured by reduced hot flush frequency and
severity, was similar to that of Divigel 0.5 mg and of Estrogel 0.75 and 1.5 mg.
CONTENTS
(continued)
304
Middle-aged female sexual dysfunction and multimorbidity: a population-based study
Ana Lúcia Ribeiro Valadares, MD, PhD, Jeffrey Frederico Lui-Filho, MD, MSc,
Lúcia Costa-Paiva, MD, PhD, and Aarão M. Pinto-Neto, MD, PhD
The main factors associated with sexual dysfunction in women with multimorbidity in this
sample were lack of sexual activity in the last month, physical inactivity, and anxiety.
311
A randomized, double-blind, placebo-controlled trial of Chinese herbal medicine granules
for the treatment of menopausal symptoms by stages
Shu-fei Fu, MD, Ying-qiang Zhao, MD, Ming Ren, MD, Jun-hua Zhang, MD, Yue-fei Wang, PhD,
Li-feng Han, PhD, Yan-xu Chang, PhD, Guan-wei Fan, MD, Hong Wang, PhD,
Yu-hong Huang, MD, Jing-bo Zhai, MSc, Jin-ying Dong, MSc, Xin Li, BM, Ju-qing Ai, MD,
Han Zhang, PhD, Yan Zhu, PhD, Bo-li Zhang, MSc, Li-kang Sun, PhD, Xiang Fan, MD,
and Xiu-mei Gao, MD, PhD
In this study the Danzhi Qing’e (DZQE) formula improved the quality of life for menopausal
women.
324
Health-related quality of life in midlife women in Qatar: relation to arthritis and
symptoms of joint pain
Linda M. Gerber, PhD, Ya-Lin Chiu, MS, Mohamud Verjee, MBChB,
and Hassan Ghomrawi, PhD, MPH
Self-report of osteoarthritis or rheumatoid arthritis was associated with reduced quality of life
among midlife women living in Qatar, yet their prevalence was low. High rates of reporting joint
pain, even among women who did not report having arthritis, may indicate that musculoskeletal
diseases are under-diagnosed.
Brief Report
330
Continuous transdermal nitroglycerin therapy for menopausal hot flashes: a single-arm,
dose-escalation trial
Alison J. Huang, MD, MAS, Steven R. Cummings, MD, MPH, Michael Schembri, BA,
Eric Vittinghoff, PhD, Peter Ganz, MD, and Deborah Grady, MD, MPH
Continuous nitroglycerin therapy may substantially and reversibly decrease hot flash frequency
and severity.
Review Articles
335
Hormone therapy for ovarian cancer survivors: systematic review and meta-analysis
Vasilios Pergialiotis, MD, MSc, PhD, Elina Pitsouni, MD, MSc, Anastasia Prodromidou, MD,
Maximos Frountzas, MD, Despina N. Perrea, PhD, and Georgios D. Vlachos, MD, PhD
Hormone therapy treatment does not influence the odds of ovarian cancer recurrence, but
this conclusion must be separately confirmed due to the presence of significant limitations in
the methodological quality of the included studies.
CONTENTS
(continued)
343
Dry eye in postmenopausal women: a hormonal disorder
Intira Sriprasert, MD, Dwight W. Warren, PhD, Austin K. Mircheff, PhD,
and Frank Z. Stanczyk, PhD
Because of the high incidence of dry eye among postmenopausal women that may be related to
hormones, this study proposes that a multidisciplinary approach should be considered between
gynecologists and ophthalmologists.
Lippincott Williams & Wilkins and The North American Menopause Society cannot be held responsible for errors or for any consequences arising from the use
of the information contained in this journal. All advertising material published in this journal is expected to conform to regulatory and medical standards. The
appearance of advertising in this publication does not constitute a guarantee or endorsement by The North American Menopause Society or Lippincott Williams
& Wilkins of the quality or value of such a product or service or any claims made by its marketer.
PERMISSION TO PHOTOCOPY ARTICLES: This publication is protected by copyright. Permission to reproduce copies of articles for noncommercial use may be obtained from the Copyright Clearance Center, 222 Rosewood Drive, Danvers, MA 01923, Tel: (978) 750-8400, FAX: (978) 750-4470,
URL: http://www.copyright.com. For permissions to reuse the material for other purposes: Please go to the Journal website and click the “Permissions”
link above the title of the paper in the abstract or html window for the relevant article. Alternatively, send an email to customercare@copyright.com.
Translation Rights & Licensing queries: Please contact, Silvia Serra, Translations Rights, Licensing & Permissions Manager, Wolters Kluwer Health
(Medical Research) Ltd, 250 Waterloo Road, London SEI 8RD, UK. Phone +44 (0)207 981 0600; Silvia.Serra@wolterskluwer.com.
Menopause: The Journal of The North American Menopause Society is a registered trademark of The North American Menopause Society.
Menopause: The Journal of The North American Menopause Society (ISSN 1072-3714) is published monthly by Lippincott Williams & Wilkins,
16522 Hunters Green Parkway, Hagerstown, MD 21740-2116. Business offices are located at Two Commerce Square, 2001 Market St., Philadelphia,
PA 19103. Periodical postage paid at Hagerstown, MD, and at additional mailing offices. Annual subscription rates: United States—$494 Individual,
$1,153 Institution. Rest of World—$517 Individual, $1,153 Institution. All prices include a handling charge. Subscription orders outside the United
States must be prepaid. Subscription orders outside North America must add $15.00 for airfreight delivery. United States residents of AL, CO, DC, FL,
GA, HI, IA, ID, IN, KS, KY, LA, MD, MO, ND, NM, NV PR, RI, SC, SD, UT, VT, WA, WV add state sales tax. The GST tax of 7% must be added to
all orders shipped to Canada (Lippincott Williams & Wilkins’ GST Identification #895524239, Publications Mail Agreement #1119672). Subscription
prices outside the United States must be prepaid. Prices subject to change without notice. Visit us online at www.lww.com. Individual subscription rates
include print and access to the online version. Institutional rates are for print only; online subscriptions are available via Ovid. Institutions can choose to
purchase a print and online subscription together for a discounted rate. Institutions that wish to purchase a print subscription, please contact Lippincott
Williams & Wilkins, 16522 Hunters Green Parkway, Hagerstown, MD 21740¬2116; phone 800-638-3030 (outside the United States 301-223-2300); fax
301-223-2400. Institutions that wish to purchase an online subscription or online with print, please contact the Ovid Regional Sales Office near you or
visit www.ovid.com/site/index.jsp and select Contact and Locations. Address for subscription information, orders, or change of address: Lippincott
Williams & Wilkins, P.O. Box 1580, Hagerstown, MD 21741-1580; phone 800-638-3030 (outside the United States 301-223-2300); fax 301-223-2400.
In Japan, contact LWW Igaku-Shoin Ltd., 3-23-14 Hongo, Bunkyo-ku, Tokyo 113-0033; phone 81-3-5689-5400; fax 81-3-5689-5402. In Bangladesh,
India, Nepal, Sri Lanka, and Pakistan, contact Globe Publications Pvt. B-13 3rd Floor, A Block, Shopping Complex, Naraina Vihar, Ring Road, New
Delhi, 110028; phone 91-11-579-3211; fax 91-11-579-8876. Address advertising inquiries to Renee Artuso at Lippincott Williams & Wilkins, 530 Walnut
Street, Philadelphia, PA 19106 USA
Postmaster: Send address changes to Menopause: The Journal of The North American Menopause Society, P.O. Box 1550, Hagerstown, MD 21740.
Copyright © 2016 by The North American Menopause Society. All rights reserved. Printed in the USA.