FT NMR Systems
Serving Advanced Technology
NMR Systems For Modern NM
This is a composite image.
2
R Spectroscopy!
Compact Spectrometer Chassis
The JNM-ECS series is a compact two-channel spectrometer that retains the
advanced capabilities of the ECA spectrometer. The required installation
space is reduced by one-half when compared to conventional NMR spectrometers. When installed in combination with the optional new generation
super shielded superconducting magnets (SCM), the installation layout is very
flexible.
Innovation in NMR Digital Architecture
The JNM-ECS spectrometer incorporates the same multi-sequencer system
employed in the JNM-ECA and ECX series. A pulsed field gradient (PFG) unit
is included in the standard configuration. Programmable timing sequencers
and waveform generators built into each RF and PFG channel can independently control either synchronous or asynchronous operations of each channel. Thus, all pulse programs used for routine analyses can be smoothly executed. Furthermore, you can edit and execute more complicated and longer
pulse programs.
High-Stability and High-Accuracy Digital Spectrometer
The JNM-ECS spectrometer maintains high stability required to obtain high
quality spectra. Circuits such as RF generation, NMR lock and digital matrix
shim are digitally derived and controlled. The high-stability spectrometer is
very effective for solvent signal suppression and difference spectra measurement. The JNM-ECS beautifully and easily acquires various NMR spectra as
the JNM-ECA/ECX series does.
High-Sensitivity New Tunable Probe
The JNM-ECS series is supplied with a new generation 5 mm tunable broadband gradient probe, which integrates all of JEOL’s newest probe technologies
and achieves the world’s highest sensitivity room-temperature probe. This
achievement enables you to rapidly obtain measurement results without sacrificing conventional operability. Thus, the JNM-ECS meets the demand of highspeed measurement in modern NMR spectroscopy.
Full Automatic NMR with Advanced Software
The JNM-ECS series uses the highly-regarded Delta spectrometer control and
data processing software. Combination of an excellent automatic measurement interface of Delta and standard integrated gradient shim enables you to
always perform automatic measurement with the best resolution only by clicking one button on the software. In addition, use of an auto sample changer
and auto tuning can automate all routine measurements.
Network NMR
The JNM-ECS series is fully network capable, as are the entire JNMECA/ECX series. The ECS spectrometer operates independently of the user’s
computer and it can be controlled from any authorized network computer.
3
Full Automatic NMR
Your Competent Assistant
Delta, the spectrometer control and data processing software
used for the JNM-ECS series, has excellent automatic measurement and processing functions (one-button measurement function) that eliminate cumbersome operations. After setting the
sample, the user need only enter the sample name and click the
desired button. Delta performs all necessary operations from
sample transfer, tuning, gradient shim, acquisition, data processing and printing. The standard one-button measurement function
can automate various NMR measurements such as two-dimensional NMR measurement, as well as one-dimensional measurement of 1H and 13C or other nuclei. The one-button measurement
function can be freely modified for different purposes in universities, laboratories and companies. The JNM-ECS series is
designed to support your routine NMR needs.
JEOL Automatic Probe Tuning and Matching
JEOL’s automatic probe tuning and matching mechanism, first pioneered and developed by JEOL in
1985, is recognized for reliable operation and a total shipments of 790 units worldwide (as of February
2007). Auto tuning is indispensable for continuous automatic measurements including multinuclear measurements. The JEOL’s Auto Tuning Unit automatically performs tuning and matching for all nuclei supported by auto tunable probes. The standard auto tunable probe covers all common NMR frequencies
from 1H/19F and 109Ag to 31P. The operator does not have to crawl under the instrument to tune the
probe. Since the Auto Tuning Unit is independent of the probe, this unit can be used in common with all
probes such as an auto-tuning inverse probes and auto-tuning 10 mm-diameter probe.
4
Versatile Automatic Sample Changers
All auto sample changers provided by JEOL can be connected to the JNM-ECS series and when combined with
the automatic measurement functions of Delta plays an
important role in sample throughput in laboratories where a
great number of samples are routinely measured. The
auto sample changer is designed to safely transport
your valuable samples with high reliability from its safety
mechanism. In addition, JEOL’s auto sample changer
eliminates the risk of breaking the sample tubes caused
by directly grasping the glass sample tube. Furthermore,
this changer can simultaneously handle various sample
tubes, for example, short tubes and tubes with different
diameters.
2D gradient shim (Z1, Z2, Z3, Z4, Z5, Z6)
strychnine/CDCl3
after FG shim
3 min
before FG shim
:02
902
802
702
602
502
402
302
Gradient Shim
During gradient shim, the magnetic field distribution over the sample region is measured using the magnetic field gradient, and the shim values are calculated and corrected so that the magnetic-field distribution becomes uniform. The use of gradient shim optimizes high-order shim parameters in a very short
time and eliminates the very tedious process of manually adjusting the shims. Gradient shim offers the
best resolution NMR measurements anytime even for samples with a little liquid volume, samples with
different solvent systems and fully automatic unattended measurement because gradient shim is automatically executed. Furthermore, even when a solvent has multiple signals such as methanol-d4 and
toluene-d8, gradient shim with selective-excitation pulses is executed.
5
ECS Delta
- Network Cyber-Enabled NMR The JNM-ECS series easily connects to the network as the JNMECA/ECX series does. Since the host computer and the ECS spectrometer operate independently of each other, you do not have to
regard them as dedicated terminals for each NMR system. That is, all
NMR systems adapt to a many-to-many communication paradigm
where the NMR systems connected to a network can be operated
from any authorized PC connected to the network. (Note 1) You can
check a progress of an NMR measurement, or queue up a new
experiment, or run system calibration methods – all from the PC on
your desk or any other authorized PC on your network. (Notes 2 and 3)
Going to an NMR room is necessary only when you set samples in
the auto sample changer and collect the samples after they are run.
Furthermore, the ECS spectrometer incorporates an independent
high-performance computer and a hard disk. Even when the spectrometer is disconnected from the host computer, the acquired data
are surely stored.
(Note 1) We ensure many-to-many communications only for PCs provided by JEOL.
(Note 2) The PC might not be connected depending on the status of the basic network.
Please consult your local JEOL office and the network administrator.
(Note 3) We ensure the operations of the NMR systems for the cross connection
between the host computer and the spectrometer.
Compatible With Windows & MacOS
Delta, the spectrometer control and data processing software for the
JNM-ECS series, is compatible with both WindowsXP (Note 4) and
MacOSX. (Note 5) You no more need an expensive additional UNIX
workstation. Using Delta on your PC, all NMR measurements and
data processing can be performed. (Note 6)
(Note 4) The compatibility with Windows Vista is being under development (as of March 2007).
(Note 5) The compatibility with Intel Mac is being under development (as
of March 2007).
(Note 6) We do not ensure the software operations under all environments. Please check the operations using the free-of-charge
Delta software introduced on the back cover of this catalog.
6
Room Temperature Probe With
the World’s Highest Sensitivity
The 40TH5AT/FG Probe, a broadband, auto tunable probe for the JNM-ECS series, achieves the
world’s highest sensitivity for 1H and 13C observation, due to JEOL’s high-end probe technologies
accumulated over many years. Guaranteed sensitivities without a thin-special sample tube are 200 (Note 1)
(ASTM) for 13C and 280 (0.1 % ethyl benzene) for 1H. This means that sensitivity improvement is an
about 20% increase for 13C and an about 50% increase for 1H compared to conventional equivalent
probes. This high-sensitivity probe and excellent 1H performance make it very useful for inverse detection measurement. Application of the new high-sensitivity 40TH5AT/FG probe makes it possible for the
JNM-ECS series to achieve improved detection limits and a shorter measurement time while maintaining conventional high operability. Furthermore, this powerful probe extends the low-frequency band,
making it possible to observe and irradiate 109Ag to 31P (Note 2), and 1H/19F. Combination with the Auto Tuning Unit makes automatic tuning and matching these nuclei possible.
(Note 1) This value is obtained when using an optional 13C high-sensitivity preamplifier. When this preamplifier is not used, the
guaranteed value is 190.
(Note 2) For 89Yg to 135Ba, please consult your local JEOL office.
HO
Molecular Formula = C43H71NO15
CH3
CHO
CH3
H3CO
O
H3C
O
N(CH3)2
HO
O
O
OCOCH3
HO
O
CH3
CH3
O
OCOCH2CH(CH3)2
CH3
Josamycin
10% ethylbenzene in CDCl3 , 13C{1H}, 1scan
5mg Josamycin in CDCl3, 13C-1H HSQC, 4 scans
Versatile Probe Lineups
The JNM-ECS series adapts to not only broadband probe, but also various probes such as automatically-tuned inverse probe, high-resolution 10 mm-diameter probe, and reduced background probes 29Si.
You can select additional probes according to your research needs.
7
Support For High-End Applications
DOSY
–Analysis of multi-component mixture samples using difference of diffusion coefficients–
The DOSY method is mainly used to analyze multi-component mixture samples. Signals deriving from each component in a
mixture are separated in an NMR spectrum according to the difference of the diffusion coefficients of respective components.
You can analyze additives or impurities in a sample, reactive intermediates impossible to isolate, and the polymerization
degree of polymers, without giving a chemical or physical influence on the sample. High performance design of the JNM-ECS
spectrometer and extensive processing algorithms of the Delta software make it possible for the JNM-ECS series to achieve
separation of NMR spectra of multi components, which were previously difficult to analyze conventionally.
NMR Metabolomics
–Analysis of biological samples–
The JNM-ECS series is also suited to NMR metabonomics.
NMR metabolome analysis uses proton spectra of biological
samples, performs pattern recognition and classification
between samples by multivariate analysis, and obtains knowledge and information on pathological conditions. Since multivariate analysis can be applied to not only metabolites but also various mixture samples, versatile applications are possible. The
Alice2 for Metabolome software (option) fully automates multisample processing of NMR data to statistical analysis. The JNMECS series enables various measurements necessary for NMR
metabolomics to be automatically performed, including solvent
suppression, T2 filter, diffusion filter, and J-resolved spectra.
This software was co-developed with Nippon Medical School.
Separation example of nerol and geraniol
(cis-trans isomer)
CH3
CH3
OH
OH
H3C
H3C
CH3
trans
7.0
6.0
5.0
4.0
CH3
cis
ppm 3.0
2.0
1.0
0
7.0
6.0
5.0
4.0
ppm 3.0
2.0
1.0
0
Slice data of DOSY 2D spectrum in the upper figure
(left: nerol, right: geraniol).
(Data courtesy: Masamichi Nakakoshi, Assistant Professor at Yokohama National University)
[Alice2 for Metabolome] software
GLP Tool
–Checking the operation status of the NMR system–
The GLP tool (sample kit is optional) running on the JNM-ECS series can automatically execute a periodic inspection protocol, enabling you to monitor the operational status of the NMR system.
21CFR Part II
–Adopted in the pharmaceutical industry–
8
The JNM-ECS series can be optionally configured to conform to USA FDA 21 CFR Part 11. The ECS
series has functions required for this rule recently adopted by drug manufacturers, ranging from management of operator data and reliable electronic signature to management of operation history.
MICCS (patent applied for)
Syringe pump
–Real-time monitoring of chemical reactions–
MICCS (MIcro Channeled Cell for Synthesis monitoring) is an
interface microchip for NMR, which is designed to be used
with the standard NMR probe. MICCS-NMR uses a syringe
pump from the top of the magnet to inject raw materials from
multiple inlets, giving rise to a chemical reaction in the MICCS.
With this mechanism, MICCS allows real-time monitoring of
chemical reactions by NMR.
Exhaust
XY alignment guide
MICCS
5mm O. D.
sample tube
Deuterated solvent
for external lock
Enlarged
view
Schematic diagram of MICCS-NMR
MICCS-NMR
Gradient shimmed at each temperature
diethyltoluamide
-60c
-40c
-20c
0c
20c
40c
Combination of No-D NMR and variable
temperature measurement
No-D NMR
–Low cost, high throughput–
No-D NMR is used for NMR measurements of organic substance without exchanging original light solvents for deuterated solvents. The absence of deuterated solvents can greatly reduces a cost and a
time required from sample preparation to NMR measurement. In addition, an advantage of not exchanging the solvents means that measurement of an unstable sample may be possible because the original
solvent can be kept from the time of synthesis.
The JNM-ECS series fully automates No-D NMR: 1H selective gradient shim using light solvent signals,
detecting and suppressing light solvent signals, chemical shift reference, and No-Lock NMR measurements. Thus, you can run No-D NMR data without adding special hardware.
9
Greatly Reduced Stray Fields
Drift Rate of 4 Hz/h Guaranteed by Super Self-Shielded SCM
Super Self-Shielded SCM (option)
The JNM-ECS series employs a standard self-shielded (SS) superconducting magnet and optionally is
available with the new super self-shielded (SSS) superconducting magnet (SCM). This new SCM greatly reduces a stray field. The 5 gauss line reduced by the super self-shielded SCM goes down to 1/100
and 1/7 compared to a non-shielded SCM and a self-shielded SCM, respectively. In combination with
the compact main console, the JNM-ECS series requires a smaller installation space, giving you added
flexibility in the layout of your NMR laboratory. Since the self-shielding mechanism of the SCM is
designed to reduce not only the stray field but also the influence from other external magnetic fields, you
can install multiple NMR systems close to each other.
SCM
SSS SCM
0.5mT line
SSS SCM
0.5mT line
SS SCM
0.5mT line
normal SCM
0.5mT line
SS SCM
0.5mT line
normal SCM
0.5mT line
Guarantees Drift Rate of 4 Hz/h
Generally, the magnetic field stability needed for high-resolution NMR systems is about 5 Hz or less in
an unlocked mode. In terms of the stability for high-quality NMR spectral acquisition, JEOL guarantees
a drift rate of 4 Hz/h or less. JEOL’s SCM that meets the performance needed to obtain high resolution
spectra can be used by anyone without anxiety.
Highly Reliable Vibration Isolation
JEOL’s NMR systems can be equipped with optional vibration isolation systems that eliminate minute
vibrations from the floor which have an adverse effect on NMR spectra. Several different styles of vibration isolation are available; please consult your local JEOL office.
10
Basic Specifications
Spectrometer section
Observation nuclei
Auto tuning/matching range
Observation frequency
Sensitivity for
13
C
Sensitivity for 1H
1
H/19F, 31P to 15N, 39K to 109Ag
All observation nuclei(Note 1)
1
H: 400 MHz, 13C: 100 MHz
190 (ASTM)
280 (0.1% ethyl benzene)
Variable temperature range 100 to 180° C
Room-temperature shim
Liquid He holding time
Liquid N2 holding time
(depending on the probe)
Digital matrix shim, 21 items controlled
200 days (refill volume: 54 L)
14 days (refill volume: 67 L)
(Note 1) Ensured only for 2H surrounding nuclei. It is necessary to provide the
2H surrounding nuclei observation automatic switching (BTO option).
Standard Configuration
Installation Requirements
Spectrometer
Power and Grounding
Spectrometer console
For spectrometer
Head amplifier chassis
(RF power monitor, preamplifier for observation/NMR lock)
Auto tune 5 mm FG/TH tunable probe
1 axis field gradient system
Variable temperature control unit
(low-temperature measurement is optional)
Air compressor or air dryer 1 set
Sample kit
Superconducting magnet
Superconducting magnet
(with level probes for liquid He/N2 and liquid He transfer tube)
Vibration isolation system
Single phase, 100 V/120 V/200V/220V/240V AC,
50/60Hz, 3 kVA
For data system
Single phase, 100 to 240V AC,
50/60Hz, 1 kVA
For air compressors Single phase, 100V/120V AC,50/60Hz, 3kVA
Auxiliary
Single phase, 100V/120V AC,50/60Hz, 3kVA
Grounding
100 Ohms or less 1
Note) Another power supply is required depending on options included.
Installation room
Room temperature
Humidity
Ceiling height:
0.5 mT position:
Data system
Host computer (WindowsXP or MacOSX)
Color liquid-crystal display monitor, keyboard and mouse
Air compressor
17 to 27° C (fluctuation: 1° C/h or less)
70% or less
2.83 m or more (top of the SCM)
Vertical: 1.5 m from SCM center
Radial: 1.0 m from SCM center
Air tank
Ventilation fan
Superconducting magnet 0.5mT
Delta software
1mT
2mT
5mT
Laser printer
Switchboard
Optional Attachments
Head amplifier
chassis
Auto sample changer (8, 16, 64 samples/load)
Probes
13C high-sensitivity preamplifier (BTO option)
4.5 m
Auto tuning unit
Spectrometer
Service access
2H
surrounding nuclei observation automatic switching (BTO option)
MICCS
Low temperature measurement unit (10 L, 30 L Dewar)
Nitrogen supplier
Liquid nitrogen recycler
Low temperature air supply system
Part of optional attachments (functions) is included in the photographs of the instrument appearance and the descriptions in
the catalog.
Operation
table
(option)
Installation entrance
0.88 m (width) 2 m (height) or more
3.5 m
*Specifications subject to change without prior notice.
11
NMR Data Processing Software -DeltaDelta, the NMR data processing software used for the JNM-ECS
series, can be downloaded from JEOL’s global website
(http://www.jeol.com/) free of charge. (Note 1)
Delta has the same capabilities as those of optional software for JEOL
NMR system, thus offering versatile data processing on your PC. (Note 2)
Delta incorporates a tutorial manual, enabling you to use this software
at once.
Since Delta is compatible with various data formats,you can experience
NMR data analysis on your desktop. (Note 3)
(Note 1) You need to register as a user on a web (free of charge). Note that the freeof-charge software is out of warrantee and support.
(Note 2) This software operates under an environment where the operation system
beginning with Windows2000/XP, RedHat Linux 7.3 or MacOSX 10.3 is
installed. The software might not operate properly depending on the configuration or performance of a PC.
(Note 3) For the data not formatted with the Delta software are basically subject to FID
data processing only. For the data not using JEOL data format, data processing might require special operations.
Certain products in this brochure are controlled under the “Foreign Exchange and Foreign
Trade Law” of Japan in compliance with international security export control. JEOL Ltd. must
provide the Japanese Government with “End-user’s Statement of Assurance” and “End-use
Certificate” in order to obtain the export license needed for export from Japan. If the product
to be exported is in this category, the end user will be asked to fill in these certificate forms.
http://www.jeol.com/
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