CENTRO NACIONAL DE MICROBIOLOGÍA
Publicaciones Científicas
ÁREA DE PATOLOGÍA MOLECULAR (años 2012-2014)
UNIDAD DE BIOLOGÍA VIRAL
Más V, Melero JA. Entry of enveloped viruses into host cells: membrane fusion. Subcell Biochem.
2013;68:467-87.
Mata M, Martinez I, Melero JA, Tenor H, Cortijo J. Roflumilast inhibits respiratory syncytial virus
infection in human differentiated bronchial epithelial cells. PLoS ONE. 2013;8(7): e69670.
Melero JA, Moore ML. Influence of respiratory syncytial virus strain differences on pathogenesis and
immunity. Curr Top Microbiol Immunol. 2013;372:59-82.
Rodriguez A, Falcon A, Cuevas MT, Pozo F, Guerra S, García-Barreno B, Martinez-Orellana P,
Pérez-Breña P, Montoya M, Melero JA, Pizarro M, Ortin J, Casas I, Nieto A. Characterization in vitro
and in vivo of a pandemic H1N1 influenza virus from a fatal case. PLoS One. 2013;8(1):e53515.
Canziani GA, Melero JA, Lacy ER. Characterization of neutralizing affinity-matured human respiratory
syncytial virus F binding antibodies in the sub-picomolar affinity range. J Mol Recognit.
2012;25(3):136-46.
Johnstone C, Ramos M, García-Barreno B, López D, Melero JA, Del Val M. Exogenous, TAPindependent lysosomal presentation of a respiratory syncytial virus CTL epitope. Immunol Cell Biol.
2012 Aug 28. doi: 10.1038/icb.2012.43.
Magro M, Mas V, Chappell K, Vázquez M, Cano O, Luque D, Terrón MC, Melero JA, Palomo C.
Neutralizing antibodies against the preactive form of respiratory syncytial virus fusion protein offer
unique possibilities for clinical intervention. Proc Natl Acad Sci U S A. 2012;109(8):3089-94.
Mata M, Sarrion I, Armengot M, Carda C, Martinez I, Melero JA, Cortijo J. Respiratory syncytial virus
inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of Nacetylcysteine. PLoS One. 2012;7(10):e48037.
Tomé L, Frabasile S, Candia C, Pittini A, Farina N, Melero JA, Arbiza J. Selection and characterization
of human respiratory syncytial virus escape mutants resistant to a polyclonal antiserum raised against
the F protein. Arch Virol. 2012;157(6):1071-80.
UNIDAD DE BIOLOGÍA Y VARIABILIDAD DEL VIH
Pérez-Álvarez L, Delgado E, Vega Y, Montero V, Cuevas T, Fernández-García A, García-Riart B, Pé
rez-Castro S, Rodríguez-Real R, López-á lvarez M, Fernández-Rodríguez R, Lezaun MJ, Ordóñez P,
Ramos C, Bereciartua E, Calleja S, Sánchez-García AM, Thomson MM. Predominance of CXCR4
tropism in HIV-1 CRF14_BG strains from newly diagnosed infections. J Antimicrob Chemother.
2014;69(1):246-53.
Córdoba EV, Arnaiz E, Relloso M, Sánchez-Torres C, García F, Pérez-Álvarez L, Gómez R, de la
Mata FJ, Pion M, Muñoz-Fernández MA. Development of sulphated and naphthylsulfonated
carbosilane dendrimers as topical microbicides to prevent HIV-1 sexual transmission. AIDS.
2013;27(8):1219-29.
Díez-Fuertes F, Delgado E, Vega Y, Fernández-García A, Cuevas MT, Pinilla M, García V, PérezÁlvarez L and Thomson MM. Improvement of HIV-1 coreceptor tropism prediction by employing
selected nucleotide positions of the env gene in a Bayesian network classifier. J Antimicrob
Chemother. 2013 March 19. doi:10.1093/jac/dkt077.
Vega Y, Delgado E, Carrera C, Nebreda P, Fernández-García A, Cuevas MT, Pérez-Álvarez L,
Thomson MM. Identification of new and unusual rev and nef transcripts expressed by an HIV type 1
primary isolate. AIDS Res Hum Retroviruses. 2013;29(7):1075-8.
Delgado E, Carrera C, Nebreda P, Fernández-García A, Pinilla M, García V, Pérez-Álvarez L,
Thomson MM. Identification of new splice sites used for generation of rev transcripts in human
immunodeficiency virus type 1 subtype C primary isolates. PLoS One. 2012;7(2):e30574.
Delgado E, Fernández-García A, Vega Y, Cuevas T, Pinilla M, García V, Sánchez M, González M,
Sánchez AM, Thomson MM, Pérez-Álvarez L. Evaluation of genotypic tropism prediction tests
compared with in vitro co-receptor usage in HIV-1 primary isolates of diverse subtypes. J Antimicrob
Chemother. 2012;67(1):25-31.
Fernández-García A, Revilla A, Vázquez-De Parga E, Vinogradova A, Rakhmanova A, Karamov E,
Carrera C, Delgado E, Pérez-Álvarez L, Nájera R, Osmanov S, Thomson MM. The analysis of near
full-length genome sequences of HIV type 1 subtype A viruses from russia supports the monophyly of
major intrasubtype clusters. AIDS Res Hum Retroviruses. 2012;28(10):1340-3.
Thomson MM, Ferńndez-García A, Delgado E, Vega Y, Díez-Fuertes F, Śnchez-Martínez M, Pinilla M,
Castro MA, Mariño A, Ordóñez P, Ocampo A, Da Silva AR, Pérez-Castro S, López-Álvarez MJ, Trigo
M, Pérez-Álvarez L. Rapid expansion of a HIV-1 subtype f cluster of recent origin among men who
have sex with men in galicia spain. J Acquir Immune Defic Syndr. 2012;59(3):e49-51.
UNIDAD DE EXPRESIÓN VIRAL
Herrero L, Monroy N, González ME. HIV-1 vpu protein mediates the transport of potassium in
saccharomyces cerevisiae. Biochemistry. 2013;52(1):171-7.
UNIDAD DE GENÉTICA BACTERIANA
Domenech A, Tirado-Vélez JM, Fenoll A, Ardanuy C, Yuste J, Linãres J, De La Campa AG.
Fluoroquinolone-resistant pneumococci: Dynamics of serotypes and clones in spain in 2012 compared
with those from 2002 and 2006. Antimicrob Agents Chemother. 2014;58(4):2393-9.
Balsalobre L, Ortegaand M, de la Campa AG. Characterization of recombinant fluoroquinoloneresistant pneumococcus-like isolates. Antimicrob Agents Chemother. 2013;57(1):254-60.
Domenech A, Ardanuy C, Roman, Pallarés R, Grau I, Santos S, de la Campa AG, Liñares J. Some
pneumococcal serotypes are more frequently associated with relapses of acute exacerbations in
COPD patients. PLoS One. 2013;8(3):e59027.
Ferrándiz MJ, de la Campa AG. The Fluoroquinolone Levofloxacin Triggers the Transcriptional
Activation of Iron Transport Genes that Contribute to Cell Death in Streptococcus pneumoniae.
Antimicrob Agents Chemother. 2014 Jan;58(1):247-57.
Domenech A, Ardanuy C, Balsalobre L, Marti S, Calatayud L, De La Campa AG, Brueggemann AB,
Liñaresa J. Pneumococci can persistently colonize adult patients with chronic respiratory disease. J
Clin Microbiol. 2012;50(12):4047-53.
UNIDAD DE INFECCIÓN VIRAL E INMUNIDAD
Guzmán-Fulgencio M, García-Álvarez M, Berenguer J, Jiménez-Sousa MA, Cosín J, Pineda-Tenor D,
Carrero A, Aldámiz T, Alvarez E, López JC, Resino S. Vitamin D deficiency is associated with severity
of liver disease in HIV/HCV coinfected patients. J Infect. 2014;68(2):176-84.
Guzmán-Fulgencio M, Rallón N, Berenguer J, Fernández-Rodríguez A, Soriano V, Miralles P,
Jiménez-Sousa MA, Restrepo C, López J, García-Álvarez M, Aldámiz T, Benito JM, Resino S.
European mitochondrial haplogroups are not associated with hepatitis C virus (HCV) treatment
response in HIV/HCV-coinfected patients. HIV Med. 2014 doi: 10.1111/hiv.12126.
Jiménez-Sousa MA, Berenguer J, Fernández-Rodríguez A, Micheloud D, Guzmán-Fulgencio M,
Miralles P, Pineda-Tenor D, García-Álvarez M, Lõpez JC, Aldámiz-Echevarria T, Carrero A, Resino S.
IL28RA polymorphism (rs10903035) is associated with insulin resistance in HIV/HCV-coinfected
patients. J Viral Hepat. 2014;21(3):189-97.
Pineda-Tenor D, Berenguer J, García-Broncano P, Jiménez-Sousa MA, Fernández-Rodríguez A, Diez
C, García-Álvarez M, Carrero A, Catalán P, Aldámiz-Echevarria T, Resino S. Association of
adiponectin (ADIPOQ) rs2241766 polymorphism and dyslipidemia in HIV/HCV-coinfected patients.
Eur J Clin Invest. 2014 Feb 15. doi: 10.1111/eci.12250. [Epub ahead of print]
Ãlvaro-Meca A, Jensen J, Micheloud D, Dã-az A, Gurbindo D, Resino S. Rate of candidiasis among
HIV-infected children in spain in the era of highly active antiretroviral therapy (1997--2008). BMC Infect
Dis. 2013 Mar 4;13:115.
Alvaro-Meca A, Rodríguez-Gijón L, Díaz A, Gil A, Resino S. Incidence and mortality of tuberculosis
disease in Spain between 1997 and 2010: Impact of human immunodeficiency virus (HIV) status. J
Infect. 2013 Dec 21. pii: S0163-4453(13)00379-4. doi: 10.1016/j.jinf.2013.12.003. [Epub ahead of
print]
Fernández-Rodríguez A, Berenguer J, Jiménez-Sousa MA, Guzmán-Fulgencio M, Micheloud D,
Miralles P, López JC, Bellón JM, Aldamiz-Echevarria T, García-Broncano P, Carrero A, Álvarez E,
Resino S. Prediction of hepatic fibrosis in patients coinfected with human immunodeficiency virus and
hepatitis C virus based on genetic markers. J Acquir Immune Defic Syndr. 2013;64(5):434-42.
Fernández-Rodríguez A, Jiménez-Sousa MA, Resino S. Comment on: 'interleukin-28 polymorphisms
on the SVR in the treatment of naïve chronic hepatitis C with pegylated interferon-α plus ribavirin: A
meta-analysis'. Gene. 2013 Jun 10;522(1):121.
Fernández-Rodríguez A, Rallón N, Berenguer J, Jiménez-Sousa MA, Cosín J, Guzmán-Fulgencio M,
Restrepo C, Lopez JC, García-Álvarez M, Miralles P, Soriano V, Benito JM, Resino S. Analysis of
IL28B alleles with virologic response patterns and plasma cytokine levels in HIV/HCV coinfected
patients. AIDS. 2013;27(2):163-73.
García-Álvarez M, Berenguer J, Álvarez E, Guzmán-Fulgencio M, Cosín J, Miralles P, Catalán P,
López JC, Rodríguez JM, Micheloud D, Muñoz-Fernández MÁ, Resino S. Association of torque teno
virus (TTV) and torque teno mini virus (TTMV) with liver disease among patients coinfected with
human immunodeficiency virus and hepatitis C virus. Eur J Clin Microbiol Infect Dis. 2013;32(2):28997.
Guzmán-Fulgencio M, Berenguer J, García-álvarez M, Fernández-Rodríguez A, Jiménez-Sousa MA,
álvarez E, Micheloud D, López JC, Miralles P, Cosín J, Catalán P, Resino S. IL28B polymorphisms
are associated with severity of liver disease in human immunodeficiency virus (HIV) patients
coinfected with hepatitis C virus. J Infect. 2013;66(2):170-8.
Guzmán-Fulgencio M, Berenguer J, Micheloud D, Fernández-Rodríguez A, García-Álvarez M,
Jiménez-Sousa MA, Bellón JM, Campos Y, Cosín J, Aldámiz-Echevarría T, Catalán P, López JC,
Resino S. European mitochondrial haplogroups are associated with CD41 T cell recovery in HIVinfected patients on combination antiretroviral therapy. J Antimicrob Chemother. 2013;68(10):2349-57.
Guzmán-Fulgencio M, Berenguer J, Rallón N, Fernández-Rodríguez A, Miralles P, Soriano V,
Jiménez-Sousa MA, Cosín J, Medrano J, García-Álvarez M, López JC, Benito JM, Resino S. HLA-E
variants are associated with sustained virological response in HIV/hepatitis C virus-coinfected patients
on hepatitis C virus therapy. AIDS. 2013;27(8):1231-8.
Guzmán-Fulgencio M, Jiménez JL, García-Álvarez M, María Bellón J, Fernández-Rodriguez A,
Campos Y, Rodríguez C, González-Garcia J, Riera M, Viciana P, Ángeles Muñoz-Fernández M,
Resino S. Mitochondrial haplogroups are associated with clinical pattern of AIDS progression in
human immunodeficiency virus infected patients. J Acquir Immune Defic Syndr. 2013;63(2):178-83.
Guzmán-Fulgencio M, Jiménez JL, Jiménez-Sousa MA, Bellón JM, García-Álvarez M, Soriano V,
Gijón-Vidaurreta P, Bernal-Morell E, Viciana P, Muñoz-Fernández MAA, Resino S. ACSM4
polymorphisms are associated with rapid AIDS progression in human immunodeficiency virus infected
patients. J Acquir Immune Defic Syndr. 2013 Aug 26. [Epub ahead of print] PMID: 23982661
Jiménez-Sousa MA, Berenguer J, Rallõn N, Guzmán-Fulgencio M, Lõpez JC, Soriano V, FernándezRodríguez A, Cosín J, Restrepo C, García-Álvarez M, Miralles P, Benito JM, Resino S. IL28RA
polymorphism is associated with early hepatitis C virus (HCV) treatment failure in human
immunodeficiency virus-/HCV-coinfected patients. J Viral Hepat. 2013;20(5):358-66.
Jimenez-Sousa MA, Fernandez-Rodriguez A, Guzman-Fulgencio M, Garcia-Alvarez M, Resino S.
Meta-analysis: Implications of interleukin-28B polymorphisms in spontaneous and treatment-related
clearance for patients with hepatitis C. BMC Med. 2013 Jan 8;11(1):6.
Mata M, Martinez I, Melero JA, Tenor H, Cortijo J. Roflumilast inhibits respiratory syncytial virus
infection in human differentiated bronchial epithelial cells. PLoS ONE. 2013;8(7): e69670.
Andaluz-Ojeda D, Bobillo F, Iglesias V, Almansa R, Rico L, Gandía F, Resino S, Tamayo E, de
Lejarazu RO, Bermejo-Martin JF. A combined score of pro- and anti-inflammatory interleukins
improves mortality prediction in severe sepsis. Cytokine. 2012;57(3):332-6.
Berenguer J, Fernandez-Rodríguez A, Jimenez-Sousa MA, Cosín J, Zarate P, Micheloud D, López
JC, Miralles P, Catalán P, Resino S. High plasma CXCL10 levels are associated with HCV-genotype
1, and higher insulin resistance, fibrosis, and HIV viral load in HIV/HCV coinfected patients. Cytokine.
2012;57(1):25-9.
García-Álvarez M, Berenguer J, Guzman-Fulgencio M, Álvarez E, Cosín J, Micheloud D, JimenezSousa MA, Fernández-Rodríguez A, Aldámiz-Echevarría T, Carrero A, Miralles P, Resino S. Bacterial
DNA translocation and liver disease severity among HIV infected patients with chronic hepatitis C. J
Acquir Immune Defic Syndr. 2012 Dec 15;61(5):552-6.
Guzmán-Fulgencio M, Berenguer J, García-Álvarez M, Fernández-Rodríguez A, Jiménez-Sousa MA,
Alvarez E, Micheloud D, López JC, Miralles P, Cosín J, Catalán P, Resino S. IL28B polymorphisms
are associated with severity of liver disease in human immunodeficiency virus (HIV) patients
coinfected with hepatitis C virus. J Infect. 2013;66(2):170-8.
Guzmán-Fulgencio M, Jiménez JL, Berenguer J, Fernández-Rodríguez A, López JC, Cosín J, Miralles
P, Micheloud D, Muñoz-Fernández MA, Resino S. Plasma IL-6 and IL-9 predict the failure of
interferon-α plus ribavirin therapy in HIV/HCV-coinfected patients. J Antimicrob Chemother.
2012;67(5):1238-45.
Jensen J, Álvaro-Meca A, Micheloud D, Díaz A, Resino S. Reduction in mycobacterial disease among
HIV-infected children in the highly active antiretroviral therapy era (1997-2008). Pediatr Infect Dis J.
2012;31(3):278-83.
Jiménez-Sousa MA, Fernández-Rodríguez A, Heredia M, Tamayo E, Guzmán-Fulgencio M, Lajo C,
López E, Gómez-Herreras JI, Bustamante J, Bermejo-Martín JF, Resino S. Genetic polymorphisms
located in TGFB1, AGTR1, and VEGFA genes are associated to chronic renal allograft dysfunction.
Cytokine. 2012;58(3):321-6.
Jimenez-Sousa MA, López E, Fernandez-Rodríguez A, Tamayo E, Fernández-Navarro P, SeguraRoda L, Heredia M, Gómez-Herreras JI, Bustamante J, García-Gómez JM, Bermejo-Martin JF, Resino
S. Genetic polymorphisms located in genes related to immune and inflammatory processes are
associated with end-stage renal disease: A preliminary study. BMC Med Genet. 2012 Jul 20;13:58.
Mata M, Sarrion I, Armengot M, Carda C, Martinez I, Melero JA, Cortijo J. Respiratory syncytial virus
inhibits ciliagenesis in differentiated normal human bronchial epithelial cells: effectiveness of Nacetylcysteine. PLoS One. 2012;7(10):e48037.
Micheloud D, Álvaro-Meca A, Jensen J, Díaz A, Resino S. Trend of pneumonia incidence among
children infected with HIV in the era of highly active antiretroviral therapy. Pediatr Infect Dis J.
2012;31(6):599-601.
Resino S, Sánchez-Conde M, Berenguer J. Coinfection by human immunodeficiency virus and
hepatitis C virus: Noninvasive assessment and staging of fibrosis. Curr Opin Infect Dis.
2012;25(5):564-9.
UNIDAD DE INMUNOPATOLOGÍA DEL SIDA
Anta L, Blanco JL, Llibre JM, García F, Pérez-Elías MJ, Aguilera A, Pérez-Romero P, Caballero E,
Vidal C, Cañizares A, Gutiérrez F, Dalmau D, Iribarren JA, Soriano V, de Mendoza C; Drug
Resistance Platform of the Spanish AIDS Research Network. Resistance to the most recent protease
and non-nucleoside reverse transcriptase inhibitors across HIV-1 non-B subtypes. J Antimicrob
Chemother. 2013 Sep;68(9):1994-2002.
Bedoya L, Beltran M, Aunon D, Gomez-Acebo E, Alcami J. Anti-HIV Activity of 5-Hydroxytyrosol, a
Microbicidal Candidate. AIDS Res Hum Retroviruses. 2013;29(11):A108-A109.
Coiras M, Montes M, Montanuy I, López-Huertas MR, Mateos E, Le Sommer C, Garcia-Blanco MA,
Hernández-Munain C, Alcamí J, Suñé C. Transcription elongation regulator 1 (TCERG1) regulates
competent RNA polymerase II-mediated elongation of HIV-1 transcription and facilitates efficient viral
replication. Retrovirology. 2013 Oct 28;10(1):124.
Colin P, Bénureau Y, Staropoli I, Wang Y, Gonzalez N, Alcami J, Hartley O, Brelot A, ArenzanaSeisdedos F, Lagane B. HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by
chemokines. Proc Natl Acad Sci U S A. 2013 Jun 4;110(23):9475-80.
González-Bulnes L, Ibáñez I, Bedoya LM, Beltrán M, Catalán S, Alcamí J, Fustero S, Gallego J.
Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 rev protein
function. Angew Chem Int Ed Engl. 2013;52(50):13405-9.
Gonzalez N, Lynch RM, McKee K, Yuste E, Mascola JR, Alcami J. Characterization of Broadly
Neutralizing Antibodies (bNAbs) to HIV-1 Present in a Cohort of Long Term Non-Progressors
(LTNPs). AIDS Res Hum Retroviruses. 2013;29(11):A53-A53.
Guardo AC, Álvarez-Fernández C, Arberas H, García-Pérez J, García F, Bargalló ME, Maleno MJ,
Gatell JM, Mothe B, Alcami J, Sánchez-Palomino S, Plana M. Use of RT-defective HIV virions: New
tool to evaluate specific response in chronic asymptomatic HIV-infected individuals. PLoS ONE.
2013;8(3).
López-Huertas MR, Mateos E, Del Cojo MS, Gómez-Esquer F, Díaz-Gil G, Rodríguez-Mora S, López
JA, Calvo E, López-Campos G, Alcamí J, Coiras M. The presence of HIV-1 tat protein second exon
delays fas protein-mediated apoptosis in CD4+ T lymphocytes: A potential mechanism for persistent
viral production. J Biol Chem. 2013;288(11):7626-44.
Pérez-Olmeda M, Alcami J. Determination of HIV tropism and its use in the clinical practice. Expert
Rev Anti Infect Ther. 2013 Dec;11(12):1291-302.
Rocafort M, Bellido R, Crespo M, Puig J, Orodea MT, Marco A, Rui L, Alcami J, Clotet,B, Paredes R,
Brander C, Mothe B. Mechanisms of Abrupt HIV Disease Progression in a Cohort of Previous Elite
and Viremic HIV Controllers. AIDS Res Hum Retroviruses. 2013;29(11):A89-A89.
Sanjuán R, Nebot MR, Peris JB, Alcamí J. Immune Activation Promotes Evolutionary Conservation of
T-Cell Epitopes in HIV-1. PLoS Biol. 2013 Apr;11(4):e1001523.
Alvarez-Fernández C, Crespo Guardo A, García-Pérez J, García F, Blanco J, Escribà-García L, Gatell
JM, Alcamí J, Plana M, Sánchez-Palomino S. Generation and Characterization of a Defective HIV-1
Virus as an Immunogen for a Therapeutic Vaccine. PLoS One. 2012;7(11):e48848.
Betancor G, Garriga C, Puertas MC, Nevot M, Anta L, Blanco JL, Pérez-Elías MJ, de Mendoza C,
Martínez MA, Martinez-Picado J, Menéndez-Arias L, Iribarren JA, Caballero E, Ribera E, Llibre JM,
Clotet B, Jaén A, Dalmau D, Gatell JM, Peraire J, Vidal F, Vidal C, Riera M, Córdoba J, Aldeguer JL,
Galindo MJ, Gutiérrez F, Álvarez M, García F, Pérez-Romero P, Viciana P, Leal M, Palomares JC,
Pineda JA, Viciana I, Santos J, Rodríguez P, Luis J, Sirvent G, Gutiérrez C, Moreno S, Pérez-Olmeda
M, Alcamí J, Rodríguez C, del Romero J, Cañizares A, Pedreira J, Miralles C, Ocampo A, Morano L,
Aguilera A, Garrido C, Manuzza G, Poveda E, Soriano V. Clinical, virological and biochemical
evidence supporting the association of HIV-1 reverse transcriptase polymorphism R284K and
thymidine analogue resistance mutations M41L, L210W and T215Y in patients failing
tenofovir/emtricitabine therapy. Retrovirology. 2012 Aug 13;9(1):68.
Heyndrickx L, Heath A, Sheik-Khalil E, Alcami J, Bongertz V, Jansson M, Malnati M, Montefiori D,
Moog C, Morris L, Osmanov S, Polonis V, Ramaswamy M, Sattentau Q, Tolazzi M, Schuitemaker H,
Willems B, Wrin T, Fenyö EM, Scarlatti G. International network for comparison of HIV neutralization
assays: The neutnet report II. PLoS ONE. 2012;7(5).
Messiaen P, de Spiegelaere W, Alcami J, Vervisch K, van Acker P, Verhasselt B, Meuwissen P,
Calonge E, Gonzalez N, Gutierrez-Rodero F, Rodriguez-Martín C, Sermijn E, Poppe B, Vogelaers D,
Verhofstede C, Vandekerckhove L. Characterization of LEDGF/p75 genetic variants and association
with HIV-1 disease progression. PLoS ONE. 2012;7(11)
Olmedo D, Sancho R, Bedoya LM, López-Pérez JL, Del Olmo E, Muñoz E, Alcamí J, Gupta MP,
Feliciano AS. 3-phenylcoumarins as inhibitors of HIV-1 replication. Molecules. 2012;17(8):9245-57.
Osorio AA, Muñóz A, Torres-Romero D, Bedoya LM, Perestelo NR, Jiménez IA, Alcamí J, Bazzocchi
IL. Olean-18-ene triterpenoids from celastraceae species inhibit HIV replication targeting NF-kB and
Sp1 dependent transcription. Eur J Med Chem. 2012;52:295-303.
Peña J, Frías M, Castro-Orgaz L, González R, García F, Gallart T, Gatell JM, Plana M; Dc2-Manon07
Vaccine Research Group. Effects on innate immunity of a therapeutic dendritic cell-based vaccine for
HIV-1 infection. Viral Immunol. 2012 Feb;25(1):37-44.
Poveda E, Paredes R, Moreno S, Alcamí J, Córdoba J, Delgado R, Gutiérrez F, Llibre JM, Deltoro
MG, Hernández-Quero J, Pulido F, Iribarren JA, García F. Update on clinical and methodological
recommendations for genotypic determination of HIV tropism to guide the usage of CCR5 antagonists.
AIDS Reviews. 2012;14(3):208-17.
UNIDAD DE PATOLOGÍA MOLECULAR DEL NEUMOCOCO
Acebo P, Martín-Galiano AJ, Navarro S, Zaballos A, Amblar M. Identification of 88 regulatory small
RNAs in the TIGR4 strain of the human pathogen Streptococcus pneumoniae. RNA. 2012;18:530-46.
Moreira RN, Domingues S, Viegas SC, Amblar M and Arraiano. Synergies between RNA degradation
and trans-translation in Streptococcus pneumoniae: cross regulation and co-transcription of RNase R
and SmpB. CMBMC Microbiology. 2012 Nov 20;12:268.
UNIDAD DE REPLICACIÓN VIRAL
Medina M, Avila J, Villanueva N. Use of okadaic acid to identify relevant phosphoepitopes in
pathology: A focus on neurodegeneration. Mar Drugs. 2013;11(5):1656-68.
Asenjo A, Cuesta I, Vivo A, Villanueva N. Phosphorylation of the human respiratory syncytial virus N
protein provokes a decrease in viral RNA synthesis. Virus Res. 2012;163(1):396-400.
UNIDAD DE VIROLOGÍA MOLECULAR
Lorenzo-Redondo R, Delgado S, Morán F, Lopez-Galindez C. Realistic three dimensional fitness
landscapes generated by self organizing maps for the analysis of experimental HIV-1 evolution. PLoS
One. 2014 Feb 28;9(2):e88579.
Bartha I, Carlson JM, Brumme CJ, McLaren PJ, Brumme ZL, John M, Haas DW, Martinez-Picado J,
Dalmau J, López-Galíndez C, Casado C, Rauch A, Günthard HF, Bernasconi E, Vernazza P, Klimkait
T, Yerly S, O'Brien SJ, Listgarten J, Pfeifer N, Lippert C, Fusi N, Kutalik Z, Allen TM, Müller V, Richard
Harrigan P, Heckerman D, Telenti A, Fellay J. A genome-to-genome analysis of associations between
human genetic variation, HIV-1 sequence diversity, and viral control. Elife. 2013 Oct 29;2:e01123. doi:
10.7554/eLife.01123.
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UNIDAD DE VIROLOGÍA MOLECULAR DE ROTAVIRUS *
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* Estas publicaciones corresponden a líneas de investigación previas a la reciente creación de la Unidad de Virología Molecular
de Rotavirus en el CNM