Product Catalogue 2014 / 15
Product Catalogue
2014 / 15
ReCiPe
ChemiCals + instruments Gmbh
Dessauerstraße 3 · 80992 munich/Germany
Phone: +49 / 89 / 54 70 81 - 0 · Fax: - 11
www.recipe.de · info@recipe.de
Certified according to
isO 9001
isO 13485
authorised representative:
Solutions for Clinical Diagnostics
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Product Catalogue
2014 / 15
Date of Release: February 2014
RECIPE
CHEMICALS + INSTRUMENTS GmbH
Dessauerstraße 3 · 80992 Munich/Germany
Phone: +49 / 89 / 54 70 81 - 0 · Fax: - 11
www.recipe.de · info@recipe.de
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About RECIPE
Who we are
RECIPE was founded in Munich in 1982 and is one of the leading companies in HPLC and LC-MS/MS
diagnostics today.
RECIPEʼs success in more than 30 years has mainly been defined by the consistent implementation of
a customer-oriented, stringent quality policy. Therefore ”quality” is not a mere phrase for us. As supplier
of diagnostic products we are rather aware of the special responsibility towards our customers, and ultimately, the patients. With our premium quality products and our competent and fast service, we are a reliable partner in laboratory diagnostics.
All diagnostic products are developed and produced in our state-of-the-art manufacturing plant. The products of our instrumentʼs branch are being serviced in our inhouse workshop. All our company processes
are controlled by a certified quality management system (ISO 13485 and ISO 9001). Furthermore we
are regularly participating in national and European proficiency schemes to secure the quality assurance
of our calibrator and control materials.
Solutions for Clinical Diagnostics
It is our goal to convince with quality, performance and innovation also in the future. In this product catalogue you will find a series of new and innovative products, which are expanding our current portfolio
especially in the sectors of therapeutic drug monitoring and automated LC-MS/MS analytics.
We would like to thank all our customers with the new edition of this product catalogue and we are looking
forward to a successful joint future in the coming years.
Alfred Bauer, General Manager
3
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New Products
................6-7
HPLC Complete Kits
ClinRep® Diagnostics . . . . . . . . . . . . . . . 10 - 85
ClinRep® Therapeutic Drug Monitoring . . 86 - 105
ClinTox® Human Biomonitoring . . . . 106 - 115
LC-MS/MS
ClinMass® Complete Kits . . . . . . . . . . 118 - 135
ClinMass® Optimisation Mixes and
Internal Standards . . . . . . 136 - 141
Quality Assurance
ClinTest® Solutions . . . . . . . . . . . . . . . 144 - 151
ClinCal® Calibrators . . . . . . . . . . . . . . 152 - 177
ClinChek® Controls . . . . . . . . . . . . . . . 178 - 207
HPLC Instruments
ClinLab® HPLC Instruments . . . . . . . 210 - 231
Chromatography Software . . . . . . . . 232 - 233
HPLC Accessories
ClinRep® Reagents for Chromatography . . . 236
ClinLab® HPLC Accessories . . . . . . . 237 - 239
Index . . . . . . . . . . . . . . . . . . . . . . . . 240 - 244
5
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New Products
HPLC Complete Kits
ClinRep® Diagnostics
Oxidative Stress
ß-Carotene in Plasma / Serum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 - 65
Quality Assurance
ClinRep TDM
®
Antiepileptic Drugs
Antiepileptics in Serum / Plasma, advanced . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 - 95
ClinTest® Standard and Test Solutions
Antiepileptics in Serum / Plasma with UHPLC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 96 - 97
Test Solution for ß-Carotene . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Levetiracetam (Keppra ) in Serum / Plasma . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 100 - 101
Standard Solution for Levetiracetam (Keppra®) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
®
Levetiracetam (Keppra ) in Serum / Plasma, Gilson ASPEC™ . . . . . . . . . . . . . . 100 - 101
®
®
ClinCal® Calibrators
Urine Calibrator for Occupational Medicine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Urine Calibrator for Phenolic Compounds . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
LC-MS/MS
Serum Calibrator Set for Antiepileptics 2 (Level 0 - 3) . . . . . . . . . . . . . . . . . . . . . . . . . . . 173
Serum Calibrator Set for Ethylglucuronide (Level 0 - 3) . . . . . . . . . . . . . . . . . . . . . . . . . 174
Serum Calibrator Set for Homocysteine (Level 0 - 3) . . . . . . . . . . . . . . . . . . . . . . . . . . . 174
ClinMass Complete Kits
Serum Calibrator for Levetiracetam (Keppra®) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 174
Alcoholism
Whole Blood Calibrator Set (filter spots) for Homocysteine (Level 0 - 3) . . . . . . . . . . . . 177
Ethylglucuronide and Ethylsulfate in Urine, Plasma and Serum . . . . . . . . . . . . . . 120 - 121
Whole Blood Calibrator for Immunosuppressants (Level 7) . . . . . . . . . . . . . . . . . . . . . . 177
®
Immunosuppressants
Immunosuppressants in Whole Blood, advanced – On-Line Analysis . . . . . . . . . . 124 - 125
ClinChek® Controls
Metabolic Disease
CSF/Serum Control for CSF/Serum Quotients, Level I, II . . . . . . . . . . . . . . . . . . . . . . . . 203
Homocysteine in Plasma / Serum . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 126 - 127
Serum Control for Ethylglucuronide, Level I, II . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Homocysteine in Whole Blood (DBS) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 128 - 129
Serum Control for Levetiracetam (Keppra®), Level I, II . . . . . . . . . . . . . . . . . . . . . . . . . . 204
Vitamin Status
Serum Control for 25-OH Vitamin D2 / D3, Level I, II . . . . . . . . . . . . . . . . . . . . . . . . . . . 205
Methylmalonic Acid in Serum / Plasma / Urine, advanced . . . . . . . . . . . . . . . . . . . 132 - 133
Whole Blood Control (filter spots) for Homocysteine, Level I, II . . . . . . . . . . . . . . . . . . . 207
25-OH Vitamin D2 / D3 in Plasma and Serum – On-Line Analysis . . . . . . . . . . . . 134 - 135
ClinMass® Optimisation Mixes and Internal Standards
Optimisation Mix for 25-OH Vitamin D2 / D3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139
ClinLab® Instruments
Optimisation Mix for 25-OH Vitamin D3 and C-3 Epimer . . . . . . . . . . . . . . . . . . . . . . . . . 139
Internal Standard for Ethylglucuronide (Plasma / Serum) . . . . . . . . . . . . . . . . . . . . . . . . 140
6
Internal Standards for Homocysteine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
HPLC Thermostats
Internal Standard for Immunosuppressants . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
HPLC Thermostat, Model HT4000 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228 - 229
7
HPLC Complete Kits
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HPLC Complete Kits
ClinRep®
Diagnostics
ClinRep®
Therapeutic Drug Monitoring
ClinTox®
Human Biomonitoring
ClinRep® HPLC Complete Kits are intended for
diagnosis and therapeutic drug monitoring (TDM)
in clinical, toxicological and forensic laboratories.
ClinTox® HPLC Complete Kits are designed for
human biomonitoring (HBM) in laboratories for
occupational medicine.
Our test kits can be used with any conventional
HPLC system. A complete kit contains all components required for analysis, such as buffers, reagents for sample preparation, standards, and a
matrix calibrator. Start accessories (such as guard-,
SPE-, and analytical columns), matrix controls,
and further accessories are additionally available.
9
Diagnostics
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HPLC Complete Kits
ClinRep® Diagnostics
for clinical, toxicological and forensic analysis
Alcoholism, Drug Abuse
Hemoglobin A1c (HbA1c)
CDT in Serum
in Whole Blood with VariantTM . . . . . . . . 50 - 51
– Manual sample preparation . . . . . . . . 12 - 13
Hemoglobin Variants and β-Thalassemia
– On-Line Analysis . . . . . . . . . . . . . . . . . 14 - 15
Screening in Whole Blood . . . . . . . . . . 52 - 53
– On-Line Analysis, automated . . . . . . 16 - 17
Metabolic Diseases
TOX.I.S.TM (On-Line Analysis)
5-Aminolevulinic Acid /
– Basic Drugs in Urine . . . . . . . . . . . . . . 18 - 19
Porphobilinogen in Urine . . . . . . . . . . . 54 - 55
– Pharmaceuticals in Plasma . . . . . . . . 20 - 21
Homocysteine in Plasma . . . . . . . . . . . . 56 - 57
– Pharmaceuticals in Urine . . . . . . . . . . 20 - 21
Hydroxyproline in Urine . . . . . . . . . . . . 58 - 59
Biogenic Amines
Porphyrins Differentiated in Urine . . . . 60 - 61
Catecholamines in Plasma . . . . . . . . . . 22 - 23
Total Porphyrins in Urine . . . . . . . . . . . 62 - 63
Catecholamines in Urine
Oxidative Stress
– Manual sample preparation . . . . . . . . 24 - 25
β-Carotene in Plasma / Serum . . . . . . . . 64 - 65
– with Gilson® ASPEC™ XL . . . . . . . . . . 26 - 27
Coenzyme Q10 in Whole Blood /
– with HTA, Model HT400E . . . . . . . . . . 28 - 29
Plasma / Serum . . . . . . . . . . . . . . . . . . . . 66 - 67
– On-Line Analysis . . . . . . . . . . . . . . . . . 30 - 31
Malondialdehyde in Plasma / Serum . . . 68 - 69
Metanephrines in Urine
Vitamin C in Plasma . . . . . . . . . . . . . . . . 70 - 71
– Manual sample preparation . . . . . . . . 32 - 33
Vitamin Status
– with Gilson® ASPEC™ XL . . . . . . . . . . 34 - 35
Vitamin A and E in Plasma . . . . . . . . . . 72 - 73
– with HTA, Model HT400E . . . . . . . . . . 36 - 37
Vitamin B1 in Whole Blood . . . . . . . . . . 74 - 75
Serotonin in Plasma . . . . . . . . . . . . . . . 38 - 39
Vitamin B2 in Whole Blood . . . . . . . . . . 76 - 77
Serotonin in Urine . . . . . . . . . . . . . . . . . 40 - 41
Vitamin B6 in Plasma / Whole Blood . . . 78 - 79
VMA, HVA, 5-HIAA in Urine
Vitamin B1, B2, B6 (Combikit) . . . . . . . 80 - 81
– Manual sample preparation . . . . . . . . 42 - 43
25-OH Vitamin D2 / D3
– with Gilson ASPEC™ XL . . . . . . . . . . 44 - 45
in Plasma and Serum
– with HTA, Model HT400E . . . . . . . . . . 46 - 47
– with HPLC . . . . . . . . . . . . . . . . . . . . . . 82 - 83
Diabetes, Hemoglobins
– with UHPLC . . . . . . . . . . . . . . . . . . . . . 84 - 85
®
Hemoglobin A1c (HbA1c)
in Whole Blood with DiamatTM . . . . . . . . 48 - 49
11
of CDT measurement.
Native sample, normal range
and on detector sensitivity
HPLC Parameters
Pump:
ternary gradient pump,
flow rates: 1.2, 2.0 ml/min
Injection volume:
400 - 500 μl
Injection interval:
20 min
UV/VIS-Detector:
460 nm
HPLC-Thermostat: 40 °C
Sample Preparation
Stabilisation/Precipitation:
150 μl serum
30 μl
10 μl mixture of
Stabilising Reagent S Precipitants P1+P2
➜
1. incubate (30 min, 4 °C)
➜
HPLC Analysis:
➜ Quantification of all relevant
transferrin isoforms
(incl. hexasialotransferrin)
9.57
6.71
4.25
10
5.98
15
5
0
0
1
2
3
4
5
6
7
8
9
10
0
1
2
3
4
5
6
7
8
9
10
Retention Time (min)
Retention Time (min)
Disialotransferrin: 6.22 min, Trisialotransferrin: 6.85 min,
Tetrasialotransferrin: 7.73 min, Pentasialotransferrin: 8.75 min,
Hexasialotransferrin: 9.65 min
Asialotransferrin: 4.25 min, Disialotransferrin: 5.98 min,
Trisialotransferrin: 6.71 min, Tetrasialotransferrin: 7.69 min,
Pentasialotransferrin: 8.66 min, Hexasialotransferrin: 9.57 min
Ordering Information
Order No.
Description
Quantity
21000
ClinRep® Complete Kit for CDT in Serum for 100 assays
1 pce.
Kit Components (order no. 21000):
Mobile Phase A
Mobile Phase B
Mobile Phase C
Sample Preparation Vials
Stabilising Reagent S
Precipitant P1
Precipitant P2
Diluting Solution D
Manual
Quick Reference
3 x 21007 (3 x 2000 ml)
2000 ml
2000 ml
2 x 21020 (2 x 100 pcs.)
3 ml
1 ml
2 ml
100 ml
1 pce.
1 pce.
21014
Optional Components:
Test Solution
15 ml
21030
21032
Start Accessories:
Analytical Column with test chromatogram
Cartridge incl. 1 precolumn
1 pce.
1 pce.
21031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
21033
FK5305
FK5810
FW3000
RC2002
Accessories:
Precolumns
Sample loop, PEEK, 500 μl
PEEK tubing (connection of prefilter and column)
Fixed-Wavelength-VIS-Detector (460 nm), complete
Sodium-Hypochlorite-Solution (5 %)
5 pcs.
1 pce.
1 pce.
1 pce.
12 ml
21080
21081
21082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
21007
21008
21009
21020
21021
21022
21023
21024
Inject 400 - 500 μl
➜ Unique chromatographical
resolution
8.75
0
2. centrifuge
1.0 ml Diluting
Solution D
9.65
5
6.85
10
7.69
20
15
8.66
25
20
Intensity (mV)
25
Dilution:
100 μl
supernatant
30
7.73
30
CDT in Serum
Test Data
LLOD:
0.1 %*
LLOQ:
0.3 %*
Intraassay precision: 4.2 %
Interassay precision: 4.3 %
* depending on the amount of total transferrin
Native sample, pathological range
6.22
Alcoholism, Drug Abuse
Intensity (mV)
CDT (carbohydrate deficient transferrin) is the most
specific parameter for chronic alcohol abuse. The
ClinRep® HPLC Complete Kit for CDT provides a
unique chromatographical resolution compared to
other commercially available test kits. The analytical
method correlates with the candidate reference
method of the IFCC-CDT-WG* and ensures a reliable
separation of all relevant transferrin isoforms (a-,
mono-, di-,…, hexasialotransferrin). This applies in
particular for disialotransferrin, the most important
CDT isoform. Alternatively to this method with manual
sample preparation, ClinRep® Complete Kits for online analysis and automated on-line analysis via 96well plates are available (see pages 14 - 17).
* Working group of the IFCC for the international standardisation
Diagnostics
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➜ Baseline-separation of
disialotransferrin
13
of CDT measurement.
Native sample, normal range
Native sample, pathological range
Test Data
LLOD:
0.1 %*
LLOQ:
0.3 %*
Intraassay precision: 4.5 %
Interassay precision: 3.9 %
* depending on the amount of total transferrin
6.21
30
0
7.84
5.19
10
7.15
20
4.52
7.86
5.17
10
7.13
20
3.02
30
4.50
CDT in Serum –
On-Line Analysis
40
6.17
40
Intensity (mV)
Alcoholism, Drug Abuse
Intensity (mV)
This ClinRep® Complete Kit is designed for the fast
analysis of CDT with on-line HPLC. It features an
injection interval of 9.5 min only and provides a unique chromatographical resolution compared to other
commercially available test kits. Analogously to our
CDT off-line method (see pages 12 - 13), the online procedure correlates with the candidate reference method of the IFCC-CDT-WG*. Prior to the
sample injection, a simple dilution step is required
(”sample pretreatment“, see below). Alternatively,
the dilution can be performed automated via 96well plates. For this purpose an additional ClinRep®
Complete Kit is available (see pages 16 - 17).
* Working group of the IFCC for the international standardisation
Diagnostics
Diagnostics
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0
0
1
2
3
4
5
6
7
8
0
1
2
3
4
5
6
7
8
Retention Time (min)
Retention Time (min)
Disialotransferrin: 4.50 min, Trisialotransferrin: 5.17 min,
Tetrasialotransferrin: 6.17 min, Pentasialotransferrin: 7.13 min,
Hexasialotransferrin: 7.86 min
Asialotransferrin: 3.02 min, Disialotransferrin: 4.52 min,
Trisialotransferrin: 5.19 min, Tetrasialotransferrin: 6.21 min,
Pentasialotransferrin: 7.15 min, Hexasialotransferrin: 7.84 min
and on detector sensitivity
HPLC Parameters
Pump 1:
binary gradient pump,
flow rate: 1.4 ml/min
Pump 2:
isocratic pump,
flow rate: 0.4 ml/min
Injection volume:
400 - 500 μl
Injection interval:
9.5 min
UV/VIS-Detector:
460 nm
HPLC-Thermostat: 40 °C
Sample Pretreatment
Ordering Information
Order No.
Description
Quantity
21100
ClinRep® Complete Kit for CDT in Serum for 300 assays
1 pce.
Kit Components (order no. 21100):
Mobile Phase A
Mobile Phase B
Mobile Phase C
Vials for Sample Pretreatment with Diluting Solution
Manual
Quick Reference
3 x 21007 (3 x 2000 ml)
2000 ml
2 x 21009 (2 x 2000 ml)
6 x 21120 (6 x 50 pcs.)
1 pce.
1 pce.
21014
Optional Components:
Test Solution
15 ml
21030
21032
FK5820
FK7400
Start Accessories:
Analytical Column with test chromatogram
Cartridge incl. 1 precolumn
Stainless steel prefilter holder
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
1
21031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
21033
FK1102
FK5305
FK5810
FK5821
FK7330
FK7340
FK7350
FW3000
RC2002
Accessories:
Precolumn
Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK)
Sample loop, PEEK, 500 μl
PEEK tubing (connection of prefilter and column)
Replacement filter for stainless steel prefilter holder
Endfittings
Sealings and sieves
Endstoppers
Fixed-Wavelength-VIS-Detector (460 nm), complete
Sodium-Hypochlorite-Solution (5 %)
5 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
2 pcs.
4 pcs. each
2 pcs.
1 pce.
12 ml
21080
21081
21082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
21007
21008
21009
21120
Dilution:
Pipette 100 μl serum into a pretreatment vial
(contains 1 ml diluting solution)
➜
1. incubate (30 min, 4 °C)
2. centrifuge
HPLC Analysis:
pce.
pce.
pce.
pce.
Inject 400 - 500 μl
➜ One step sample
pretreatment
➜ Fast analysis: injection
interval of 9.5 min only
➜ Unique chromatographical
quality
15
of CDT measurement.
Native sample, normal range
Native sample, pathological range
6.21
30
0
Test Data
LLOD:
0.1 %*
LLOQ:
0.3 %*
Intraassay precision: 2.8 %
Interassay precision: 2.5 %
* depending on the amount of total transferrin
7.84
5.19
10
7.15
20
4.52
7.86
5.17
10
7.13
20
3.02
30
4.50
CDT in Serum –
Automated
On-Line Analysis
40
6.17
40
Intensity (mV)
Alcoholism, Drug Abuse
Intensity (mV)
This ClinRep® Complete Kit from RECIPE is designed
for the fast, reliable and fully automated quantification of CDT. Sample preparation is performed by
on-line HPLC and automated sample pretreatment
using 96-well plates. The kit provides a unique chromatographical resolution compared to other commercially available test kits. The analytical method
correlates with the candidate reference method of
the IFCC-CDT-WG* and ensures a reliable separation of all relevant transferrin isoforms (a-, mono-,
di-, …, hexasialotransferrin). This applies in particular for disialotransferrin, the most important CDT
isoform. An accurate calculation of the CDT value
is ensured by baseline separation.
* Working group of the IFCC for the international standardisation
Diagnostics
Diagnostics
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0
0
1
2
3
4
5
6
7
8
0
1
2
3
4
5
6
7
8
Retention Time (min)
Retention Time (min)
Disialotransferrin: 4.50 min, Trisialotransferrin: 5.17 min,
Tetrasialotransferrin: 6.17 min, Pentasialotransferrin: 7.13 min,
Hexasialotransferrin: 7.86 min
Asialotransferrin: 3.02 min, Disialotransferrin: 4.52 min,
Trisialotransferrin: 5.19 min, Tetrasialotransferrin: 6.21 min,
Pentasialotransferrin: 7.15 min, Hexasialotransferrin: 7.84 min
Ordering Information
and on detector sensitivity
HPLC Parameters
Pump 1:
binary gradient pump,
flow rate: 1.4 ml/min
Pump 2:
isocratic pump,
flow rate: 0.4 ml/min
Injection volume:
400 μl
Injection interval:
9.5 min
UV/VIS-Detector:
460 nm
HPLC-Thermostat: 40 °C
Sample Pretreatment (automated, 96-well plates)
Dilution:
500 μl Diluting Solution D
50 μl serum
➜
1. incubate (30 min, 4 °C)
2. centrifuge
Order No.
Description
Quantity
21200
ClinRep® Complete Kit for CDT in Serum for 300 assays
1 pce.
Kit Components (order no. 21200):
Mobile Phase A
Mobile Phase B
Mobile Phase C
D Diluting Solution
Manual
Quick Reference
3 x 21007 (3 x 2000 ml)
2000 ml
2 x 21009 (2 x 2000 ml)
3 x 21221 (3 x 50 ml)
1 pce.
1 pce.
21014
Optional Components:
Test Solution
15 ml
21030
21032
FK5820
FK7400
Start Accessories:
Analytical Column with test chromatogram
Cartridge incl. 1 precolumn
Stainless steel prefilter holder
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
1
21031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
21033
21220
FK1102
FK5305
FK5810
FK5821
FK7330
FK7340
FK7350
FW3000
RC2002
Accessories:
Precolumns
Deepwell plate 96/500μl
Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK)
Sample loop, PEEK, 500 μl
PEEK tubing (connection of prefilter and column)
Replacement filter for stainless steel prefilter holder
Endfittings
Sealings and sieves
Endstoppers
Fixed-Wavelength-VIS-Detector (460 nm), complete
Sodium-Hypochlorite-Solution (5 %)
5 pcs.
8 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
2 pcs.
4 pcs. each
2 pcs.
1 pce.
12 ml
21080
21081
21082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
21007
21008
21009
21221
pce.
pce.
pce.
pce.
On-Line Analysis:
Inject 400 μl
➜ Fully automated method
(96-well plates)
➜ Fast analysis: injection
interval of 9.5 min only
➜ Unique chromatographical
resolution
17
Chromatogram of the ClinTest® Test Solution
Alcoholism, Drug Abuse
500
Basic Drugs in Urine –
On-Line Analysis
35.45
31.81
100
26.27
21.82
200
27.88
300
23.64
24.87
21.33
40.09
400
mAU
This ClinRep® Reagent Kit is intended for use with
the TOX.I.S.™ System from Shimadzu, an on-line
HPLC system which has been designed for automated drug screening (on-line analysis).
The analytical method allows for the reliable screening of more than 300 illegal drugs, such as morphine, methadone, and amphetamine.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 18
0
RECIPE and Shimadzu are offering a complete
solution for the screening of illegal drugs in urine.
15
20
25
30
35
40
Retention Time (min)
The TOX.I.S.™ system from Shimadzu is an on-line
HPLC-system with photodiode array detection. It has
been designed for the qualitative (and semiquantitative) screening for acute poisoning, drug abuse
and doping.
MDA: 21.33 min, Amphetamine: 21.82 min,
6-Acetylmorphine: 23.64 min, Methadone: 24.87 min,
Morphine: 26.27 min, Tilidine: 27.88 min,
Codeine: 31.81 min, EDDP: 35.45 min, IS: 40.09 min
Ordering Information
The RECIPE reagent kit ensures a reliable and standardised HPLC analysis with Shimadzuʼs TOX.I.S.™
system and contains buffers, an internal standard,
and a test solution. Also, columns and accessories
are provided.
Shimadzuʼs analytical method allows for an automated screening of more than 300 alkaline* drugs
of abuse. The analyte identification bases on the
comparison of retention times and UV spectra. For
this purpose, the evaluation software of the system
provides an extensive UV spectra library.
* For
the drug screening of acidic, neutral, and weak alkaline
pharmaceuticals, additional reagent kits for the analysis from
urine and plasma are available (see pages 20 - 21).
Order No.
Description
Quantity
60000
ClinRep® Reagent Kit for the TOX.I.S.™ System from Shimadzu for 100 assays
1 pce.
60007
60008
60009
60012
60014
60021
Kit Components (order no. 60000):
Mobile Phase A
Mobile Phase B
SPE-Buffer
IS Internal Standard
Test Solution
SPE-Washing Solution
2500 ml
5000 ml
2500 ml
50 ml
2 x 60014 (2 x 15 ml)
2 x 60021 (2 x 2500 ml)
60006
Additional Components:
Mobile Phase AB
2500 ml
60030
60031
60032
60033
60034
Start Accessories:
Analytical Column with test chromatogram
SPE-Column Holder incl. 1 SPE-Column
SPE-Column
Guard Column Holder incl. 1 Guard Column
Guard Columns
1 pce.
1 pce.
1 pce.
1 pce.
10 pcs.
19
38.6
Chromatogram of the ClinTest® Test Solution
Alcoholism, Drug Abuse
10
Both RECIPE reagent kits ensure a reliable and
standardised HPLC analysis with Shimadzuʼs
TOX.I.S.™ System and contain buffers, an internal
standard, a test solution, and a reagent for sample
pretreatment. Columns and accessories are additionally available.
Shimadzuʼs analytical method allows for an automated drug screening of more than 500 pharmaceutical compounds* with sedative and hypnotic
properties and high potential of abuse. The analyte
identification bases on the comparison of retention
times and UV spectra. For this purpose, the evaluation software of the system provides an extensive
UV spectra library.
33.7
27.1
50
0
RECIPE and Shimadzu are offering a complete solution for the screening of illegal drugs from plasma
(order no. 60200) and urine (order no. 60100).
The TOX.I.S.™ System from Shimadzu is an on-line
HPLC-system with photodiode array detection. It has
been designed for the qualitative (and semiquantitative) screening on acute poisoning, drug abuse
and doping.
23.7
17.5
100
28.9
12.0
150
Pharmaceuticals in
Plasma and Urine –
On-Line Analysis
mAU
These ClinRep® Reagent Kits are intended for use
with the TOX.I.S.™ System from Shimadzu, an online HPLC system, which has been designed for
automated drug screening (on-line analysis).
Shimadzu's analytical method provides automated
determination of more than 500 different pharmaceuticals from plasma and urine.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 20
15
20
25
30
35
40
Retention Time (min)
Doxylamine: 12.0 min, Norclozapine: 17.5 min,
Doxepin: 23.7 min, Carbamazepine: 27.1 min,
Oxazepam: 28.9 min, Temazepam: 33.7, IS: 38.6 min
Pharmaceuticals in Plasma – On-Line Analysis
Ordering Information
Order No.
Description
Quantity
60200
ClinRep® Reagent Kit for the TOX.I.S.™ System from Shimadzu for 100 assays
1 pce.
60007
60008
60109
60212
60114
60021
60221
Kit Components (order no. 60200):
Mobile Phase A
Mobile Phase B
SPE-Buffer
IS Internal Standard
Test Solution
SPE-Washing Solution
D Diluting Solution
2500 ml
5000 ml
2500 ml
30 ml
2 x 60114 (2 x 15 ml)
2500 ml
100 ml
60130
60131
60132
60133
60134
Start Accessories:
Analytical Column with test chromatogram
SPE-Column Holder incl. 1 SPE-Column
SPE-Column
Guard Column Holder incl. 1 Guard Column
Guard Columns
1 pce.
1 pce.
1 pce.
1 pce.
10 pcs.
Pharmaceuticals in Urine – On-Line Analysis
Ordering Information
* Compounds with acidic, neutral, and weak alkaline properties.
For the screening of illegal alkaline drugs, such as morphine,
methadone, and amphetamine, an additional reagent kit is offered
(see pages 18 - 19).
Order No.
Description
Quantity
60100
ClinRep® Reagent Kit for the TOX.I.S.™ System from Shimadzu for 100 assays
1 pce.
60007
60008
60109
60112
60114
60021
60122
Kit Components (order no. 60100):
Mobile Phase A
Mobile Phase B
SPE-Buffer
IS Internal Standard
Test Solution
SPE-Washing Solution
Enzyme Solution
2500 ml
5000 ml
2500 ml
50 ml
2 x 60114 (2 x 15 ml)
2500 ml
1 ml
60130
60131
60132
60133
60134
Start Accessories:
Analytical Column with test chromatogram
SPE-Column Holder incl. 1 SPE-Column
SPE-Column
Guard Column Holder incl. 1 Guard Column
Guard Columns
1 pce.
1 pce.
1 pce.
1 pce.
10 pcs.
21
40
10 - 2500 ng/l
70 - 90 %
5 ng/l
10 ng/l
6.7 % (NE),
7.6 % (E),
6.1 % (D)
Interassay precision: 5.3 % (NE),
4.2 % (E),
3.9 % (D)
Sample Preparation
Extraction:
Apply 1 ml plasma and 50 μl Internal Standard IS
to a sample preparation column
➜
Elution:
wash (3 x 1 ml Washing
Solution W)
Elute with 120 μl Eluting Reagent E
➜
HPLC Analysis:
collect the eluate
7.56
40
4.28
50
7.55
50
30
10
12.05
20
12.02
20
5.07
Intensity (mV)
30
10
0
0
Test Data
Linearity:
Recovery:
LLOD:
LLOQ:
Intraassay precision:
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
40 μl
Injection interval:
15 min
EC-Detector:
potential: 500 mV,
sensitivity: 10 nA
Temperature:
25 °C (or ambient)
➜ Reliable sample
preparation
ClinChek® Plasma Control, Level II
4.28
Catecholamines
in Plasma
ClinChek® Plasma Control, Level I
5.08
Biogenic Amines
Intensity (mV)
Epinephrine (E), norepinephrine (NE), and dopamine
(D) are termed as catecholamines. The determination of catecholamines is primarily used for helping
to detect and rule out pheochromocytomas in symptomatic patients, i.e. in patients with persistent
hypertension. It is also used in order to help monitor
for recurrence when a pheochromocytoma has been
discovered and removed. For these purposes, this
ClinRep® Complete Kit allows for a quick and safe
quantification of the catecholamines. The kit is easy
to use and is characterised by an extraordinarily
good lower detection limit.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 22
-10
-10
0
2
4
6
8
10
12
14
0
Retention Time (min)
Norepinephrine: 4.28 min, Epinephrine: 5.08 min,
IS: 7.55 min, Dopamine: 12.05 min
2
4
6
8
10
12
14
Retention Time (min)
Norepinephrine: 4.28 min, Epinephrine: 5.07 min,
IS: 7.56 min, Dopamine: 12.02 min
Ordering Information
Order No.
Description
Quantity
1000
ClinRep® Complete Kit for Catecholamines in Plasma for 250 assays
1 pce.
Kit components (order no. 1000):
Mobile Phase
Standard Solution
IS Internal Standard
Plasma Calibrator, lyophil.
Sample Preparation Columns incl. elution vials
W Washing Solution
E Eluting Reagent
Manual
Quick Reference
1000 ml
10 ml
15 ml
5 x 5 ml
5 x 1020 (5 x 50 pcs.)
3 x 1021 (3 x 250 ml)
30 ml
1 pce.
1 pce.
1030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
1041
1042
1060
1061
1070
1071
1072
Accessories:
2 ml sample vial with cap for storing samples
Sampling system for Plasma Catecholamines (5 ml)
Sample preparation column, empty with frit and cap
250 μl elution vial with cap
Alumina oxide
Microspatula
2 M Tris Buffer
50 pcs.
50 pcs.
50 pcs.
50 pcs.
5g
1 pce.
250 ml
8810
8811
8809
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
1210
1011
1012
1013
1020
1021
1022
Inject 40 μl
➜ Quick and safe
quantification
➜ Detection limit: 5 ng/l
23
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
200
100
flow rate: 1.0 ml/min
20 μl / 15 min
pot.: 500 mV, sen.: 10 nA
30 °C
5 ml Stab. Reagent S
(contains colour indic.)
➜
pH = 5.5 pH = 6.0
- HCI
100
0
2
4
6
8
10
12
14
0
➜
pH > 5.0
too alkaline
2
4
6
8
10
12
14
Retention Time (min)
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.93 min
Order No.
Description
Quantity
2000
ClinRep® Complete Kit for Catecholamines in Urine for 100 assays
1 pce.
Kit Components (order no. 2000):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
E Eluting Reagent
Manual
Quick Reference
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 2020 (2 x 50 pcs.)
500 ml
2 x 2024 (2 x 300 ml)
1 pce.
1 pce.
2030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK4000
Accessories:
Column Rack (for 20 columns)
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
1210
2011
2012
2013
2020
2021
2024
pH = 8.0
pH = 5.0
2.0 < pH < 5.0
ok
12.93
8.33
200
Ordering Information
30 μl Internal
Standard IS
adjust with 1 M NaOH, until the
indicator switches to yellow
pH = 2.5 pH = 3.5 pH = 4.5
pH = 2.0
300
5.89
12.92
Intensity (mV)
8.33
4.89
300
Retention Time (min)
0.8 % (NE), 1.4 % (E), 1.7 % (D)
2.0 % (NE), 2.3 % (E), 3.1 % (D)
➜
➜
Apply the whole sample on the
sample preparation column
Elution:
➜
➜ Safe and convenient
pH-adjustment
400
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.92 min
+ NaOH
Extraction:
500
400
0
Sample Preparation
pH < 2.0
too acidic
500
0
Addition of IS / pH adjustment:
pH = 1.5
600
2 - 1000 μg/l
70 - 85 %
1 μg/l / 2 μg/l
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
3 ml urine
600
5.89
Catecholamines
in Urine
ClinChek® Urine Control, Level II
4.89
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
With this complete kit, the determination of norepinephrine (NE), epinephrine (E), and dopamine (D) is
performed from urine. The sample preparation features particular user friendliness for laboratory routine. For a safe and convenient check-up of the pHvalue prior to sample extraction, a special stabilising
reagent with colour indicator is available. The distinct indicator colouring assures the setting of the
appropriate pH value range (pH 2 – 5). Alternatively
to this method with manual sample preparation,
RECIPE offers ClinRep® Complete Kits for use with
automatic pipetting systems from Gilson® (see pages
26 - 27) and HTA (see pages 28 - 29).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 24
wash (HPLC water)
Apply 6 ml Eluting Reagent E
HPLC Analysis:
➜
➜ Robust chromatography
Inject 20 μl
➜ Detection limit: 1 μg/l
25
500
400
400
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
2 - 1000 μg/l
53 - 78 %
1 μg/l / 2 μg/l
flow rate: 1.0 ml/min
20 μl / 15 min
pot.: 500 mV, sen.: 10 nA
30 °C
5 ml Stabilising Reagent S
(contains colour indicator)
➜
pH = 5.5 pH = 6.0
pH = 8.0
- HCI
➜
pH = 2.0
pH = 5.0
2.0 < pH < 5.0
ok
8
10
12
14
0
pH > 5.0
too alkaline
Addition of IS:
2
4
6
8
10
12
14
Retention Time (min)
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.93 min
Description
Quantity
2200
ClinRep® Complete Kit for Catecholamines in Urine for 100 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1 pce.
1210
2011
2012
2013
2220
2021
2224
2300
Kit components (order no. 2200):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
E Eluting Reagent
Manual
Quick Reference
ClinRep® Complete Kit for Catecholamines in Urine for 500 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 2220 (2 x 50 pcs.)
500 ml
400 ml
1 pce.
1 pce.
1 pce.
Kit components (order no. 2300):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
E Eluting Reagent
Manual
Quick Reference
5 x 1210 (5 x 1000 ml)
5 x 2011 (5 x 10 ml)
5 x 2012 (5 x 3 ml)
5 x 2013 (5 x 5 x 8 ml)
10 x 2220 (10 x 50 pcs.)
5 x 2021 (5 x 500 ml)
5 x 2224 (5 x 400 ml)
1 pce.
1 pce.
2030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
1210
2011
2012
2013
2220
2021
2224
Automated sample preparation
with Gilson® ASPEC™ XL
Add 30 μl Internal Standard IS to the sample
➜
Extraction:
6
Order No.
adjust with 1 M NaOH, until the
indicator switches to yellow
pH = 2.5 pH = 3.5 pH = 4.5
pH < 2.0
too acidic
4
Ordering Information
pH adjustment:
➜
2
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.92 min
1.2 % (NE), 1.5 % (E), 1.5 % (D)
2.7 % (NE), 2.6 % (E), 4.2 % (D)
+ NaOH
100
Retention Time (min)
Sample Preparation
pH = 1.5
200
0
0
3 ml urine
300
5.89
Intensity (mV)
100
Manual sample pretreatment
➜ Test kits available for
100 or 500 assays
12.92
200
0
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
➜ Automated sample
preparation
4.89
300
12.93
500
8.33
600
8.33
600
5.89
Catecholamines
in Urine – with
Gilson® ASPEC™ XL
ClinChek® Urine Control, Level II
4.89
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
Norepinephrine (NE), epinephrine (E), and dopamine (D) are termed as catecholamines. As an
alternative to the determination with manual sample preparation (see pages 24 - 25), RECIPE offers
appropriate ClinRep® Complete Kits for use with
automatic pipetting systems from HTA (see pages
28 - 29) and Gilson®. With the Gilson® ASPEC™ XL,
the sample preparation and -injection is performed
automatically. In advance, the pH value of the sample is checked by use of a stabilising reagent with
colour indicator (manual sample pretreatment).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 26
Apply 6 ml sample on the sample preparation column
➜ Injection interval: 15 min
➜
Elution:
wash (HPLC water)
Apply 4 ml Eluting Reagent E
➜
HPLC Analysis:
Inject 20 μl
27
500
400
400
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
2 - 1000 μg/l
90 %
1 μg/l / 2 μg/l
flow rate: 1.0 ml/min
20 μl / 15 min
pot.: 500 mV, sen.: 10 nA
30 °C
2.5 ml Stabilising Reagent S
(contains colour indicator)
➜
pH = 5.5 pH = 6.0
pH = 8.0
- HCI
➜
➜
pH = 2.0
pH = 5.0
pH < 2.0
too acidic
2.0 < pH < 5.0
ok
pH > 5.0
too alkaline
Automated sample preparation
with HT400E
Add 20 μl Internal Standard IS to the sample
6
8
10
12
14
5.89
0
2
4
6
8
10
12
14
Retention Time (min)
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.93 min
Quantity
2400
ClinRep® Complete Kit for Catecholamines in Urine for 100 assays
(Automated Sample Preparation with HT400E)
1 pce.
1210
2011
2012
2013
2420
2421
2424
FK6401
2500
Kit components (order no. 2400):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
E Eluting Reagent
Sample vials, clear glass, 4ml
Manual
Quick Reference
ClinRep® Complete Kit for Catecholamines in Urine for 500 assays
(Automated Sample Preparation with HT400E)
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 2420 (2 x 50 pcs.)
250 ml
250 ml
2 x FK6401 (2 x 100 pcs.)
1 pce.
1 pce.
1 pce.
Kit components (order no. 2500):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
E Eluting Reagent
Sample vials, clear glass, 4ml
Manual
Quick Reference
5 x 1210 (5 x 1000 ml)
5 x 2011 (5 x 10 ml)
5 x 2012 (5 x 3 ml)
5 x 2013 (5 x 5 x 8 ml)
10 x 2420 (10 x 50 pcs.)
5 x 2421 (5 x 250 ml)
5 x 2424 (5 x 250 ml)
10 x FK6401 (10 x 100 pcs.)
1 pce.
1 pce.
2030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
1210
2011
2012
2013
2420
2421
2424
FK6401
➜
Apply 3.6 ml sample on the sample preparation column
➜
Elution:
4
Description
Addition of IS:
Extraction:
2
Order No.
adjust with 1 M NaOH, until the
indicator switches to yellow
pH = 2.5 pH = 3.5 pH = 4.5
+ NaOH
100
Ordering Information
pH adjustment:
pH = 1.5
200
0
Norepinephrine: 4.89 min, Epinephrine: 5.89 min,
IS: 8.33 min, Dopamine: 12.92 min
1.8 % (NE), 2.0 % (E), 1.8 % (D)
2.5 % (NE), 2.3 % (E), 3.4 % (D)
1.5 ml urine
300
Retention Time (min)
Sample Preparation
➜ Injection interval: 15 min
Intensity (mV)
100
0
Manual sample pretreatment
➜ Test kits available for
100 or 500 assays
12.92
200
0
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
➜ Automated sample
preparation
4.89
300
12.93
500
8.33
600
8.33
600
5.89
Catecholamines
in Urine – with
HTA, Model HT400E
ClinChek® Urine Control, Level II
4.89
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
Norepinephrine (NE), epinephrine (E), and dopamine (D) are termed as catecholamines. As an
alternative to the determination with manual sample preparation (see pages 24 - 25), RECIPE offers
appropriate ClinRep® Complete Kits for use with
automatic pipetting systems from Gilson® (see pages
26 - 27) and HTA. With the HT400E from HTA, the
sample preparation and -injection is performed automatically. In advance, the pH value of the sample
is checked by use of a stabilising reagent with colour
indicator (manual sample pretreatment).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 28
wash (HPLC water)
Apply 2.5 ml Eluting Reagent E
➜
HPLC Analysis:
Inject 20 μl
29
ClinChek® Urine Control, Level I (+ 20 μl IS/ml urine)
300
0
3 - 1500 μg/l
95 - 100 %
1 μg/l
3 μg/l
3.0 % (NE),
4.5 % (E),
0.8 % (D)
Interassay precision: 3.6 % (NE),
6.4 % (E),
2.4 % (D)
HPLC Parameters
Pump 1
(SPE buffer):
isocratic pump,
flow rates: 0.5, 2.0 ml/min
Pump 2
(mobile phase):
isocratic pump,
flow rate: 1.2 ml/min
Switching valve:
6-port/3-channel switching
valve (order no. FK1102)
Injection volume:
50 μl
Injection interval:
20 min
Fluorescence
detector:
275 nm (exc.), 330 nm (em.)
HPLC-Thermostat: 30 °C
9.11
100
50
0
9 10 11 12 13 14 15 16 17 18 19 20
8
Retention Time (min)
Norepinephrine: 9.12 min, Epinephrine: 10.52 min,
IS: 12.85 min, Dopamine: 16.11 min
9 10 11 12 13 14 15 16 17 18 19 20
Retention Time (min)
Norepinephrine: 9.11 min, Epinephrine: 10.51 min,
IS: 12.84 min, Dopamine: 16.10 min
Ordering Information
Order No.
Description
Quantity
2100
ClinRep® Complete Kit for Catecholamines in Urine for 500 assays
1 pce.
Kit components (order no. 2100):
SPE - Buffer
Mobile Phase
Standard Solution
Urine Calibrator (FD), lyophil.
Manual
Quick Reference
4 x 2109 (4 x 2500 ml)
6 x 2110 (6 x 2500 ml)
10 ml
5 x 5 ml
1 pce.
1 pce.
2012
Optional components:
IS Internal Standard
3 ml
1232
1233
2130
2131
FK5810
FK5820
FK7400
Start Accessories:
Guard Column Holder
Guard Column
Analytical Column with test chromatogram
SPE - Column
PEEK capillary connector
Stainless steel prefilter holder
Inline-Filter (stainless steel sieve, free of dead volume)
1
4
1
1
1
1
1
FK1102
FK5821
FK7330
FK7340
FK7350
Accessories:
Switching valve, Sykam (6-port/3-channel incl. electr. drive, PEEK)
Replacement filter for stainless steel prefilter holder
Endfittings
Sealings and sieves
Endstoppers
1 pce.
10 pcs.
2 pcs.
4 pcs. each
2 pcs.
2180
2181
2182
ClinChek® Controls:
Urine Control (FD), lyophil., Level I
Urine Control (FD), lyophil., Level II
Urine Control (FD), lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
2109
2110
2011
2113
pce.
pcs.
pce.
pce.
pce.
pce.
pce.
Sample Pretreatment
Addition of IS:
Add 20 μl Internal Standard IS/ml urine
On-Line Analysis:
➜
➜ Robust chromatography
with fluorescence detection
150
-50
8
Test Data
Linearity:
Recovery:
LLOD:
LLOQ:
Intraassay precision:
200
Intensity (mV)
50
10.52
100
16.10
250
16.11
150
12.84
12.85
200
9.12
Catecholamines
in Urine – On-Line
Analysis
300
250
-50
➜ On-line sample preparation
ClinChek® Urine Control, Level II (+ 20 μl IS/ml urine)
10.51
Biogenic Amines
Intensity (mV)
This test kit is designed for the automated analysis
of the catecholamines. A manual sample preparation is not required, but is performed on-line within
the HPLC system!
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 30
centrifuge
Inject 50 μl
NE: Norepinephrine
E: Epinephrine
D: Dopamine
31
Also available: Test kits for automated sample preparation (see pages 34 - 37).
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
0
8 - 10000 μg/l
60 %
5 μg/l / 8 μg/l
2
4
6
8
10
12
14
flow rate: 1.0 ml/min
20 μl / 17 min
pot.: 650 mV, sen.: 50 nA
30 °C
Sample Preparation
20 μl Internal Standard IS
➜
➜
pH = 5.5
if necessary, add
1 M NaOH dropwise
15.03
9.42
2
4
6
8
10
12
14
16
Retention Time (min)
Normetanephrine: 5.25 min, Metanephrine: 6.48 min,
IS: 9.42 min, 3-Methoxytyramine: 15.03 min
Order No.
Description
Quantity
4000
ClinRep® Complete Kit for Metanephrines in Urine for 100 assays
1 pce.
Kit components (order no. 4000):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
D Diluting Solution
W Washing Solution
E Eluting Reagent
S Stabilising Reagent
Manual
Quick Reference
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 4020 (2 x 50 pcs.)
400 ml
400 ml
2 x 4024 (2 x 250 ml)
100 ml
1 pce.
1 pce.
4030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK4000
FK6300
Accessories:
Column Rack (for 20 columns)
Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C
1 pce.
50 pcs.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
4010
4011
4012
4013
4020
4022
4023
4024
4025
2. incubate (30 min, 90 - 100 °C)
Add 4 ml Diluting Solution D (contains colour indicator)
pH = 4.5 pH = 5.0
0
Ordering Information
pH adjustment:
check, if the sample
is yellow (pH > 6)
0
Retention Time (min)
1.7 % (NM), 3.0 % (M), 2.5 % (MT)
1.8 % (NM), 2.9 % (M), 1.9 % (MT)
1. adjust pH to 0.5 - 1.0
25
16
Normetanephrine: 5.26 min, Metanephrine: 6.47 min,
IS: 9.43 min, 3-Methoxytyramine: 15.03 min
1 ml urine
50
-25
0
Hydrolysis:
pH = 6.5 pH = 7.0 pH = 7.5
+ NaOH
➜
pH = 6.0
pH < 6.0
too acidic
pH > 6.0
ok
➜
Extraction:
15.03
25
-25
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
➜ Safe and convenient
pH-adjustment
5.26
50
5.25
75
Intensity (mV)
100
75
9.43
100
6.47
Metanephrines
in Urine
ClinChek® Urine Control, Level II
6.48
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
Metanephrines, i.e. metanephrine (M), normetanephrine (NM), and 3-methoxytyramine (MT), are the
primary metabolites of the catecholamines. Similar
to the catecholamines, the determination of the metanephrines is used to detect or rule out tumors of the
sympathoadrenal system. For this purpose, this
test kit of RECIPE features particular user friendlyness within sample preparation. For a safe and
convenient check-up of the pH-value prior to sample
extraction, a special diluting solution with colour
indicator is available. The distinct colouring of the
indicator assures that the analyte extraction is performed under appropriate pH conditions (pH > 6).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 32
Apply the whole sample on the
sample preparation column
➜
➜ Robust chromatography
Elution:
wash (HPLC water and
Washing Solution W)
Elute with 5 ml Eluting Reagent E
(receiver vial: 1 ml Stabilising Reagent S)
HPLC Analysis:
➜
➜ Low cost per test
collect the eluate
Inject 20 μl
33
0
-25
flow rate: 1.0 ml/min
20 μl / 17 min
pot.: 650 mV, sen.: 50 nA
30 °C
Sample Preparation
Manual sample pretreatment
Hydrolysis:
4
6
8
10
12
14
9.42
16
0
2
4
6
8
10
12
14
16
Retention Time (min)
Normetanephrine: 5.25 min, Metanephrine: 6.48 min,
IS: 9.42 min, 3-Methoxytyramine: 15.03 min
Ordering Information
Order No.
Description
Quantity
4100
ClinRep® Complete Kit for Metanephrines in Urine for 100 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1 pce.
4010
4011
4012
4013
4120
4022
4023
4124
4125
20 μl Internal Standard IS
➜
1. adjust pH to 0.5 - 1.0
2
Normetanephrine: 5.26 min, Metanephrine: 6.47 min,
IS: 9.43 min, 3-Methoxytyramine: 15.03 min
1.2 % (NM), 1.4 % (M), 1.9 % (MT)
1.9 % (NM), 2.2 % (M), 3.0 % (MT)
1 ml urine
0
Retention Time (min)
6 - 10000 μg/l
72 %
4 μg/l / 6 μg/l
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
25
-25
0
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
50
15.03
25
15.03
5.26
50
5.25
75
Intensity (mV)
100
75
9.43
100
6.47
Metanephrines
in Urine – with
Gilson® ASPEC™ XL
ClinChek® Urine Control, Level II
6.48
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
Normetanephrine (NM), metanephrine (M), and
3-methoxytyramine (MT) are termed as metanephrines. As an alternative to the determination
with manual sample preparation (see pages 32 - 33),
RECIPE offers appropriate ClinRep® Complete Kits
for use with automatic pipetting systems from HTA
(see pages 36 - 37) and Gilson®. With the Gilson®
ASPEC™ XL, the sample preparation and injection
is performed automatically. In advance, the samples
are hydrolysed in order to ensure a quantitative
release of sulfateester and glucuronide bound urinary metanephrines (manual sample pretreatment).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 34
4200
2. incubate (30 min, 90 - 100 °C)
Kit components (order no. 4100):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
D Diluting Solution
W Washing Solution
E Eluting Reagent
S Stabilising Reagent
Manual
Quick Reference
ClinRep® Complete Kit for Metanephrines in Urine for 500 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 4120 (2 x 50 pcs.)
400 ml
400 ml
250 ml
80 ml
1 pce.
1 pce.
1 pce.
pH adjustment:
Add 4 ml Diluting Solution D (contains colour indicator)
➜
check, if the sample
is yellow (pH > 6)
pH = 4.5 pH = 5.0
pH = 5.5
if necessary, add
1 M NaOH dropwise
pH = 6.5 pH = 7.0 pH = 7.5
+ NaOH
➜ Automated sample
preparation
➜
Kit components (order no. 4200):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
D Diluting Solution
W Washing Solution
E Eluting Reagent
S Stabilising Reagent
Manual
Quick Reference
5 x 4010 (5 x 1000 ml)
5 x 4011 (5 x 10 ml)
5 x 4012 (5 x 3 ml)
5 x 4013 (5 x 5 x 8 ml)
10 x 4120 (10 x 50 pcs.)
5 x 4022 (5 x 400 ml)
5 x 4023 (5 x 400 ml)
5 x 4124 (5 x 250 ml)
5 x 4125 (5 x 80 ml)
1 pce.
1 pce.
4030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK6300
Accessories:
Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C
50 pcs.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
4010
4011
4012
4013
4120
4022
4023
4124
4125
pH = 6.0
pH < 6.0
too acidic
pH > 6.0
ok
Automated sample preparation with Gilson® ASPEC™ XL
➜ Test kits available for
100 or 500 assays
Extraction:
Apply 2.5 ml sample to the sample preparation column
➜
Elution:
wash (HPLC water and
Washing Solution W)
Elute with 2.5 ml Eluting Reagent E
(receiver vial: 800 μl Stabilising Reagent S)
➜
HPLC Analysis:
collect the eluate
Inject 20 μl
35
0
flow rate: 1.0 ml/min
20 μl / 17 min
pot.: 650 mV, sen.: 50 nA
30 °C
Sample Preparation
Manual sample pretreatment
Hydrolysis:
➜
2. incubate (30 min, 90 - 100 °C)
➜
if necessary, add
1 M NaOH dropwise
pH = 6.5 pH = 7.0 pH = 7.5
+ NaOH
➜ Automated sample
preparation
➜
pH = 6.0
pH < 6.0
too acidic
8
10
12
14
16
0
pH > 6.0
ok
2
4
6
8
10
15.03
12
14
16
Retention Time (min)
Normetanephrine: 5.25 min, Metanephrine: 6.48 min,
IS: 9.42 min, 3-Methoxytyramine: 15.03 min
Description
Quantity
4300
ClinRep® Complete Kit for Metanephrines in Urine for 100 assays
(Automated Sample Preparation with HT400E)
1 pce.
4010
4011
4012
4013
4320
4022
4323
4124
4125
FK6401
4400
Kit components (order no. 4300):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
D Diluting Solution
W Washing Solution
E Eluting Reagent
S Stabilising Reagent
Sample vials, clear glass, 4ml
Manual
Quick Reference
ClinRep® Complete Kit for Metanephrines in Urine for 500 assays
(Automated Sample Preparation with HT400E)
1000 ml
10 ml
3 ml
5 x 8 ml
2 x 4320 (2 x 50 pcs.)
400 ml
500 ml
250 ml
80 ml
2 x FK6401 (2 x 100 pcs.)
1 pce.
1 pce.
1 pce.
Kit components (order no. 4400):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
D Diluting Solution
W Washing Solution
E Eluting Reagent
S Stabilising Reagent
Sample vials, clear glass, 4ml
Manual
Quick Reference
5 x 4010 (5 x 1000 ml)
5 x 4011 (5 x 10 ml)
5 x 4012 (5 x 3 ml)
5 x 4013 (5 x 5 x 8 ml)
10 x 4320 (10 x 50 pcs.)
5 x 4022 (5 x 400 ml)
5 x 4323 (5 x 500 ml)
5 x 4124 (5 x 250 ml)
5 x 4125 (5 x 80 ml)
10 x FK6401 (10 x 100 pcs.)
1 pce.
1 pce.
4030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK6300
Accessories:
Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C
50 pcs.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
Add 4 ml Diluting Solution D (contains colour indicator)
pH = 5.5
6
Order No.
pH adjustment:
pH = 4.5 pH = 5.0
4
Ordering Information
20 μl Internal Standard IS
check, if the sample
is yellow (pH > 6)
2
Normetanephrine: 5.26 min, Metanephrine: 6.47 min,
IS: 9.43 min, 3-Methoxytyramine: 15.03 min
1.0 % (NM), 1.5 % (M), 1.8 % (MT)
1.0 % (NM), 2.6 % (M), 2.9 % (MT)
1. adjust pH to 0.5 - 1.0
0
Retention Time (min)
7 - 10000 μg/l
98 %
4 μg/l / 7 μg/l
1 ml urine
25
-25
0
Test Data
Linearity:
Recovery:
LLOD / LLOQ:
Precision
Intraassay:
Interassay:
50
9.42
15.03
25
-25
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
4010
4011
4012
4013
4320
4022
4323
4124
4125
FK6401
Automated sample preparation with HT400E
➜ Test kits available for
100 or 500 assays
5.26
50
5.25
75
Intensity (mV)
100
75
9.43
100
6.47
Metanephrines
in Urine – with
HTA, Model HT400E
ClinChek® Urine Control, Level II
6.48
ClinChek® Urine Control, Level I
Biogenic Amines
Intensity (mV)
Normetanephrine (NM), metanephrine (M), and
3-methoxytyramine (MT) are termed as metanephrines. As an alternative to the determination
with manual sample preparation (see pages 32 - 33),
RECIPE offers appropriate test kits for use with
automatic pipetting systems from Gilson® (see
pages 34 - 35) and HTA. With the HT400E from
HTA the sample preparation and injection is performed automatically. In advance, the samples are
hydrolysed in order to ensure a quantitative release
of sulfateester and glucuronide bound urinary
metanephrines (manual sample pretreatment).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 36
Extraction:
Apply 2.5 ml sample to the sample preparation column
➜
Elution:
wash (HPLC water and
Washing Solution W)
Elute with 2.5 ml Eluting Reagent E
(receiver vial: 800 μl Stabilising Reagent S)
➜
HPLC Analysis:
collect the eluate
Inject 20 μl
37
ClinChek® Plasma Control, Level I
Intensity (mV)
5.56
7.13
7.13
1000
1000
Serotonin in Plasma
Test Data
Linearity:
1 - 1000 μg/l
Recovery:
80 - 90 %
LLOD:
0.5 μg/l
LLOQ:
1 μg/l
Intraassay precision: 3 %
Interassay precision: 4 %
ClinChek® Plasma Control, Level II
500
5.56
Biogenic Amines
Intensity (mV)
Serotonin is a neurotransmitter in the central nervous system. Serotonin deficiencies are connected
with disorders such as depression, schizophrenia,
and Parkinson's disease. Moreover, serotonin is
produced in excess by carcinoid tumors. Here, the
determination of serotonin, together with its metabolite 5-HIAA (see pages 42 - 47), is used to confirm or rule out the tumor. The RECIPE test kit allows
for a quick and sensitive determination of serotonin
from platelet-rich plasma, platelet-poor plasma, and
serum. For the determination from urine an additional test kit is available (see pages 40 - 41).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 38
0
500
0
-250
-250
0
2
4
6
8
10
0
Retention Time (min)
Serotonin: 5.56 min, IS: 7.13 min
2
4
6
8
10
Retention Time (min)
Serotonin: 5.56 min, IS: 7.13 min
Ordering Information
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
20 μl
Injection interval:
10 min
EC-Detector:
potential: 450 mV,
sensitivity: 20 nA
HPLC-Thermostat: 30 °C
Order No.
Description
Quantity
6000
ClinRep® Complete Kit for Serotonin in Plasma for 100 assays
1 pce.
Kit components (order no. 6000):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard, lyophil.
Plasma Calibrator, lyophil.
Sample Preparation Vials
P Precipitant
Manual
Quick Reference
1000 ml
5 x 2 ml
5 x 1 ml
5 ml
100 pcs.
22 ml
1 pce.
1 pce.
6030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
8810
8811
8809
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
6710
6711
6712
6013
6020
6021
Sample Preparation
Precipitation:
200 μl plasma
10 μl Internal Standard IS
➜
1. add 200 μl Precipitant P
2. centrifuge
HPLC Analysis:
Inject 20 μl
➜ Quick sample preparation
➜ Injection interval: 10 min
➜ High analytical sensitivity
39
ClinChek® Urine Control, Level I
132
66
66
0
0
-22
-22
0
2
4
6
8
0
10
Retention Time (min)
Serotonin: 4.13 min, IS: 5.31 min
4.11
132
5.31
200
Intensity (mV)
Test Data
Linearity:
5 - 1000 μg/l
Recovery:
70 - 85 %
LLOD:
3 μg/l
LLOQ:
5 μg/l
Intraassay precision: 3 %
Interassay precision: 4 %
200
5.31
Serotonin in Urine
ClinChek® Urine Control, Level II
4.13
Biogenic Amines
Intensity (mV)
Serotonin is an important neurotransmitter. The
main metabolite of serotonin is 5-hydroxyindole
acetic acid (5-HIAA) which is excreted with urine.
Patients with carcinoid tumors usually show
increased levels of serotonin in plasma and urine
as well as of 5-HIAA in urine (see pages 42 - 47).
As some tumors show a decreased serotonin turnover (e.g. AADC-deficient tumors), low 5-HIAA levels
must be verified by the determination of serotonin.
The test kit of RECIPE provides a highly selective
sample preparation and guarantees a reliable
chromatography.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 40
2
4
6
8
10
Retention Time (min)
Serotonin: 4.11 min, IS: 5.31 min
Ordering Information
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
20 μl
Injection interval:
10 min
EC-Detector:
potential: 450 mV,
sensitivity: 50 nA
HPLC-Thermostat: 30 °C
Sample Preparation
Order No.
Description
Quantity
7000
ClinRep® Complete Kit for Serotonin in Urine for 100 assays
1 pce.
Kit components (order no. 7000):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard, lyophil.
Urine Calibrator, lyophil.
Sample Preparation Columns
S Stabilising Reagent
W Washing Solution
E Eluting Reagent
Manual
Quick Reference
1000 ml
5 x 2 ml
5 x 1 ml
5 x 8 ml
2 x 7020 (2 x 50 pcs.)
2 x 7021 (2 x 200 ml)
200 ml
500 ml
1 pce.
1 pce.
7030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK4000
Accessories:
Column Rack (for 20 columns)
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
6710
6711
6712
7013
7020
7021
7022
7023
Dilution:
2 ml urine
➜
Extraction:
4 ml Stabilising
Reagent S
50 μl Internal
Standard IS
adjust pH to 4.5 - 6.5
Apply the whole sample on the
sample preparation column
➜
Elution:
wash (HPLC water and
Washing Solution W)
Apply 5 ml Eluting Reagent E
HPLC Analysis:
➜
➜ Highly selective sample
clean up
collect the eluate
Inject 20 μl
➜ Reliable chromatography
➜ Injection interval: 10 min
41
Test Data
Linearity:
Recovery:
LLOD:
LLOQ:
Precision
Intraassay:
Interassay:
VMA: 0.6 - 100 mg/l
HVA: 0.3 - 100 mg/l
5-HIAA: 0.2 - 50 mg/l
75 - 90 %
VMA: 0.2 mg/l
HVA: 0.1 mg/l
5-HIAA: 0.1 mg/l
VMA: 0.6 mg/l
HVA: 0.3 mg/l
5-HIAA: 0.2 mg/l
300
300
2.6
3.0
3.7
3.6
%
%
%
%
(VMA), 2.5 % (HVA),
(5-HIAA)
(VMA), 3.8 % (HVA),
(5-HIAA)
flow rate: 0.9 ml/min
20 μl / 15 min
pot.: 800 mV, sen.: 50 nA
30 °C
Addition of IS:
50 μl urine
1 ml Internal Standard IS
5.46
100
7.96
200
3.62
7.99
100
11.80
200
11.77
400
Intensity (mV)
400
0
0
2
4
6
8
10
12
0
14
Retention Time (min)
VMA: 3.67 min, IS: 5.50 min, HVA: 7.99 min,
5-HIAA: 11.80 min
2
4
6
8
10
12
14
Retention Time (min)
VMA: 3.62 min, IS: 5.46 min, HVA: 7.96 min,
5-HIAA: 11.77 min
Ordering Information
Order No.
Description
Quantity
3000
ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 100 assays
1 pce.
Kit components (order no. 3000):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard, lyophil.
Urine Calibrator, lyophil.
Sample Preparation Columns
A Ammonia Solution
B Boric Acid Solution
E Eluting Reagent
Manual
Quick Reference
1000 ml
5 x 1 ml
100 ml
5 x 5 ml
2 x 3020 (2 x 50 pcs.)
100 ml
2 x 3022 (2 x 300 ml)
2 x 3023 (2 x 100 ml)
1 pce.
1 pce.
3030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
3031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
3010
3011
3012
3013
3020
3021
3022
3023
Sample Preparation
➜
Extraction:
500
0
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
➜ Highly selective sample
preparation
ClinChek® Urine Control, Level II
500
5.50
VMA, HVA and 5-HIAA
in Urine
ClinChek® Urine Control, Level I
3.67
Biogenic Amines
Intensity (mV)
Vanillylmandelic acid (VMA) and homovanillic acid
(HVA) are end-products of the catecholamine metabolism. The determination of VMA and HVA in urine
serves as a screening test for neuroblastoma, one of
the most common solid tumors in early childhood.
5-hydroxyindoleacetic acid (5-HIAA) is a metabolite
of serotonin and is used for the diagnosis of carcinoid tumors (see pages 38 - 41). This ClinRep®
Complete Kit from RECIPE allows a reliable determination of VMA, HVA and 5-HIAA in only 15 min
time for analysis.
Also available: Complete kits for automated sample preparation (see pages 44 - 47).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 42
Apply the whole sample on the sample preparation column
➜
1. wash with 1 ml Ammonia
Solution A
2. fill up with Boric Acid B
Elution:
➜ Injection interval: 15 min
Apply 2 ml Eluting Reagent E
➜ Reliable test procedure
➜
HPLC Analysis:
collect the eluate
Inject 20 μl
43
400
400
300
300
0
Recovery:
LLOD:
LLOQ:
Precision
Intraassay:
Interassay:
VMA: 0.6 - 100 mg/l
HVA: 0.3 - 100 mg/l
5-HIAA: 0.2 - 50 mg/l
75 - 90 %
VMA: 0.2 mg/l
HVA: 0.1 mg/l
5-HIAA: 0.1 mg/l
VMA: 0.6 mg/l
HVA: 0.3 mg/l
5-HIAA: 0.2 mg/l
1.4
2.3
1.8
2.6
%
%
%
%
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
(VMA), 1.9 % (HVA),
(5-HIAA)
(VMA), 2.6 % (HVA),
(5-HIAA)
flow rate: 0.9 ml/min
20 μl / 15 min
pot.: 800 mV, sen.: 50 nA
30 °C
Sample Preparation
Automated sample preparation
with Gilson® ASPEC™ XL
➜ Automated sample
preparation
Addition of IS:
50 μl urine
1. wash with 1 ml Ammonia
Solution A
Elution:
2. wash with 2.5 ml Boric
Acid B
Apply 2 ml Eluting Reagent E
HPLC Analysis:
6
8
10
12
0
14
2
4
7.96
6
8
10
12
14
Retention Time (min)
VMA: 3.62 min, IS: 5.46 min, HVA: 7.96 min,
5-HIAA: 11.77 min
Ordering Information
Order No.
Description
Quantity
3100
ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 100 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1 pce.
3010
3011
3012
3013
3120
3021
3022
3023
3200
Kit components (order no. 3100):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
A Ammonia Solution
B Boric Acid Solution
E Eluting Reagent
Manual
Quick Reference
ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 500 assays
(Automated Sample Preparation with Gilson® ASPEC™ XL)
1000 ml
5 x 1 ml
100 ml
5 x 5 ml
2 x 3120 (2 x 50 pcs.)
100 ml
2 x 3022 (2 x 300 ml)
2 x 3023 (2 x 100 ml)
1 pce.
1 pce.
1 pce.
Kit components (order no. 3200):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
A Ammonia Solution
B Boric Acid Solution
E Eluting Reagent
Manual
Quick Reference
5 x 3010 (5 x 1000 ml)
5 x 3011 (5 x 5 x 1 ml)
5 x 3012 (5 x 100 ml)
5 x 3013 (5 x 5 x 5 ml)
10 x 3120 (10 x 50 pcs.)
5 x 3021 (5 x 100 ml)
10 x 3022 (10 x 300 ml)
10 x 3023 (10 x 100 ml)
1 pce.
1 pce.
3030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
3031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
3010
3011
3012
3013
3120
3021
3022
3023
➜
➜ Injection interval: 15 min
4
VMA: 3.67 min, IS: 5.50 min, HVA: 7.99 min,
5-HIAA: 11.80 min
Apply 1 ml sample on the sample preparation column
➜
➜ Test kits available for
100 or 500 assays
2
Retention Time (min)
1 ml Internal Standard IS
➜
Extraction:
100
0
0
Test Data
Linearity:
200
5.46
7.99
100
11.80
200
3.62
Intensity (mV)
500
11.77
ClinChek® Urine Control, Level II
500
5.50
VMA, HVA and 5-HIAA
in Urine – with
Gilson® ASPEC™ XL
ClinChek® Urine Control, Level I
3.67
Biogenic Amines
Intensity (mV)
As an alternative to the determination with manual
sample preparation (see pages 42 - 43), RECIPE
offers appropriate ClinRep® Complete Kits for use
with automatic pipetting systems from HTA (see
pages 46 - 47) and Gilson®. Both instruments allow
for an automated preparation and injection of the
samples.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 44
Inject 20 μl
45
400
400
300
300
0
Recovery:
LLOD:
LLOQ:
Precision
Intraassay:
Interassay:
VMA: 0.9 - 50 mg/l
HVA: 0.9 - 50 mg/l
5-HIAA: 0.5 - 25 mg/l
75 - 90 %
VMA: 0.3 mg/l
HVA: 0.3 mg/l
5-HIAA: 0.2 mg/l
VMA: 0.9 mg/l
HVA: 0.9 mg/l
5-HIAA: 0.5 mg/l
2.5
2.8
2.2
2.3
%
%
%
%
HPLC Parameters
Isocratic Pump:
Injection vol. / int.:
EC-Detector:
HPLC-Thermostat:
(VMA), 3.2 % (HVA),
(5-HIAA)
(VMA), 2.6 % (HVA),
(5-HIAA)
flow rate: 0.9 ml/min
20 μl / 15 min
pot.: 800 mV, sen.: 100 nA
30 °C
Sample Preparation
Automated sample preparation
with HT400E
➜ Automated sample
preparation
Addition of IS:
100 μl urine
2
4
6
8
10
12
0
14
Retention Time (min)
VMA: 3.67 min, IS: 5.50 min, HVA: 7.99 min,
5-HIAA: 11.80 min
2
4
7.96
6
8
10
12
14
Retention Time (min)
VMA: 3.62 min, IS: 5.46 min, HVA: 7.96 min,
5-HIAA: 11.77 min
Ordering Information
Order No.
Description
Quantity
3300
ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 100 assays
(Automated Sample Preparation with HT400E)
1 pce.
3010
3011
3012
3013
3320
3021
3022
3023
FK6401
FK6402
3400
Kit components (order no. 3300):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
A Ammonia Solution
B Boric Acid Solution
E Eluting Reagent
Sample vials, clear glass, 4ml
Sample vial without cap, PP, 1.5 ml
Manual
Quick Reference
ClinRep® Complete Kit for VMA, HVA, 5-HIAA in Urine for 500 assays
(Automated Sample Preparation with HT400E)
1000 ml
5 x 1 ml
100 ml
5 x 5 ml
2 x 3320 (2 x 50 pcs.)
100 ml
2 x 3022 (2 x 300 ml)
2 x 3023 (2 x 100 ml)
2 x FK6401 (2 x 100 pcs.)
100 pcs.
1 pce.
1 pce.
1 pce.
Kit components (order no. 3400):
Mobile Phase
Standard Solution, lyophil.
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
A Ammonia Solution
B Boric Acid Solution
E Eluting Reagent
Sample vials, clear glass, 4ml
Sample vial without cap, PP, 1.5 ml
Manual
Quick Reference
5 x 3010 (5 x 1000 ml)
5 x 3011 (5 x 5 x 1 ml)
5 x 3012 (5 x 100 ml)
5 x 3013 (5 x 5 x 5 ml)
10 x 3320 (10 x 50 pcs.)
5 x 3021 (5 x 100 ml)
10 x 3022 (10 x 300 ml)
10 x 3023 (10 x 100 ml)
10 x FK6401 (10 x 100 pcs.)
5 x FK6402 (5 x 100 pcs.)
1 pce.
1 pce.
3030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
3031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
3010
3011
3012
3013
3320
3021
3022
3023
FK6401
FK6402
Apply 1 ml sample on the sample preparation column
➜
➜ Test kits available for
100 or 500 assays
➜
Extraction:
900 μl Internal Standard IS
100
0
0
Test Data
Linearity:
200
5.46
7.99
100
11.80
200
3.62
Intensity (mV)
500
11.77
ClinChek® Urine Control, Level II
500
5.50
VMA, HVA and 5-HIAA
in Urine – with
HTA, Model HT400E
ClinChek® Urine Control, Level I
3.67
Biogenic Amines
Intensity (mV)
As an alternative to the determination with manual
sample preparation (see pages 42 - 43), RECIPE
offers appropriate ClinRep® Complete Kits for use with
automatic pipetting systems from Gilson® (see pages
44 - 45) and HTA. Both instruments allow for an
automated preparation and injection of the samples.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 46
1. wash with 1 ml Ammonia
Solution A
Elution:
2. wash with 2.5 ml Boric
Acid B
Apply 2 ml Eluting Reagent E
HPLC Analysis:
➜
➜ Injection interval: 15 min
Inject 20 μl
47
ClinChek® Hemolysate Control, Level I
Test Data
Linearity: The test is linear over the whole range of
physiologically occurring HbA1c values (approx. 3 16 % HbA1c).
Intraassay precision: 1 - 2 %
Interassay precision: 2 - 3 %
HPLC Parameters
for Modular HPLC Systems / for DiamatTM
Pump:
Ternary Gradient Pump /
Ternary Gradient Pump
Flow rate:
1.5 ml/min / 1.1, 1.5 or 1.8 ml/min
Injection volume:
20 μl / 20 μl
Injection interval:
5 min / 8-, 5- or 3 min programme
UV/VIS-Detector: 415 nm / 415 nm
HPLC-Thermostat: 23 °C / 23 °C
A: Venous Blood
Hemolysis:
5 μl venous blood
1.25 ml Hemolysis Reagent H
➜
HPLC Analysis:
incubate (30 min, 37 °C)
Inject 20 μl
4
B: Capillary Blood
vial with Hemolysis Reagent H
➜
HPLC Analysis:
4.0
4
3
2
2.1
1.6
3
5
1.6
Intensity
5
2.7
6
2.8
7
6
1
1
0
0
0
1
2
3
4
5
HbA1a: 1.1 min, HbA1b: 1.6 min, HbF: 2.1 min,
HbA1c: 2.8 min, HbA0: 4.0 min
0
1
2
3
4
5
Retention Time (min)
HbA1a: 1.1 min, HbA1b: 1.6 min, HbA1c: 2.7 min,
HbA0: 4.0 min
Ordering Information
Order No.
Description
Quantity
11000
ClinRep® Complete Kit for Hb A1c in Whole Blood for 1000 assays
1 pce.
Components of the Complete Kit (order no. 11000):
ClinRep® Reagent Kit
Reference Standard
Analytical Column with test chromatogram
Manual
Quick Reference
1 pce.
10 x 5 ml
1 pce.
1 pce.
1 pce.
Components of the Reagent Kit (order no. 11001):
Buffer 1
Buffer 2
Buffer 3
H Hemolysis Reagent
W Washing Solution
2 x 11007 (2 x 2400 ml)
2400 ml
2 x 11009 (2 x 2100 ml)
1300 ml
2100 ml
11001
11011
11030
11007
11008
11009
11013
11014
11031
Refill Service:
Analytical Column (refill) with test chromatogram
(original column needs to be returned)
1 pce.
11021
11022
11023
11024
11026
11027
11038
FK3000
FK5810
FK5820
FK5821
Accessories:
ClinRep® Sample Preparation Kit for Capillary Blood (for 50 assays)
containing:
50 Sample vials with 1 ml hemolysis reagent each, 1 Capillary holder
1 Capillary dispenser with 50 heparinised capillaries à 5 μl
50 Sample vials with 1 ml of hemolysis reagent each
Capillary dispenser, cont. 50 heparinised capillaries à 5 μl
Capillary holder
Sample vials 1.5 ml without cap
Hemolysis Reagent esp. for capillary blood sampling (heavy metal free)
Sample vials 1.5 ml with purple cap
Printerpaper
Thermocult Incubator (37 °C)
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
20 sets
20 pcs.
20 pcs.
1000 pcs.
2000 ml
1000 pcs.
10 rolls
1 pce.
1 pce.
1 pce.
10 pcs.
11080
11081
11082
ClinChek® Controls:
Hemolysate Control, Level I, ready for use
Hemolysate Control, Level II, ready for use
Hemolysate Control, Level I, II, ready for use
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
11020
Hemolysis:
5 μl capillary blood
➜ Column lifetime:
> 1000 analyses
8
7
2
Sample Preparation
➜ ”Gold standard” for HbA1c
analysis
9
8
Retention Time (min)
Dependence on the amount of total hemoglobin:
The HbA1c value is independent on the amount of
total hemoglobin in a range from 6 - 24 g/dl total
hemoglobin.
➜ Reliable and cost-efficient
analysis
9
1.1
Hemoglobin A1c
(HbA1c) in Whole
Blood (for DiamatTM
and Modular HPLC)
10%
4.0
10%
ClinChek® Hemolysate Control, Level II
1.1
Diabetes, Hemoglobin Testing
Intensity
Diabetes mellitus is a chronic disease which is associated with abnormally high blood glucose levels. The
determination of HbA1c is an important diagnostic
tool for monitoring the efficiency of dietary control
and therapy during treatment of diabetes mellitus.
Due to the excellent specificity and reproducibility,
HPLC is still considered as the ”gold standard”
method for the adjustment of the blood glucose concentration in diabetes patients. The HbA1c values,
obtained with this method, are in accordance with
the value level of the DCCT and are traceable to
the IFCC reference system. The kit can be applied
to the analyser DiamatTM or any conventional modular HPLC system.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 48
1 set
incubate (24 h,
ambient temperature)
Inject 20 μl
DIAMATTM is a registered trademark of BioRad
49
ClinChek® Hemolysate Control, Level I
15
10
10
1.07
Dependence on the amount of total hemoglobin:
The HbA1c value is independent on the amount of
total hemoglobin in a range from 6 - 24 g/dl total
hemoglobin.
HPLC Parameters
Pump:
Flow rate:
Injection volume:
Injection interval:
UV/VIS-Detector:
HPLC-Thermostat:
binary gradient pump
2.0 ml/min
20 μl
3 min
415 nm
23 °C
Sample Preparation
A: Venous Blood
Hemolysis:
5 μl venous blood
HPLC Analysis:
➜
➜ Reliable and cost-efficient
analysis
1.25 ml Hemolysis Reagent H
incubate (30 min, 37 °C)
Inject 20 μl
B: Capillary Blood
➜ ”Gold standard” for HbA1c
analysis
Hemolysis:
5 μl capillary blood
0
0
1
2
3
0
HbA1a: 0.40 min, HbA1b: 0.55 min, HbF: 0.75 min,
HbA1c: 1.07 min, HbA0: 1.61 min
1
2
3
Retention Time (min)
HbA1a: 0.39 min, HbA1b: 0.55 min, HbF: 0.76 min,
HbA1c: 1.03 min, HbA0: 1.61 min
Ordering Information
Order No.
Description
Quantity
11100
ClinRep® Complete Kit for Hb A1c in Whole Blood for 1000 assays
1 pce.
Components of the Complete Kit (order no. 11100):
ClinRep® Reagent Kit
Reference Standard
Analytical Column with test chromatogram
Manual
Quick Reference
1 pce.
10 x 5 ml
1 pce.
1 pce.
1 pce.
Components of the Reagent Kit (order no. 11101):
Buffer 1
Buffer 2
H Hemolysis Reagent
W Washing Solution
2 x 11107 (2 x 2400 ml)
2 x 11108 (2 x 2400 ml)
1300 ml
2100 ml
11101
11011
11130
11107
11108
11013
11014
11021
11022
11023
11024
11026
11027
11138
FK3000
FK5810
FK5820
FK5821
Accessories:
ClinRep® Sample Preparation Kit for Capillary Blood (for 50 assays)
containing:
50 Sample vials with 1 ml hemolysis reagent each, 1 Capillary holder
1 Capillary dispenser with 50 heparinised capillaries à 5 μl
50 Sample vials with 1 ml of hemolysis reagent each
Capillary dispenser, cont. 50 heparinised capillaries à 5 μl
Capillary holder
Sample vials 1.5 ml without cap
Hemolysis Reagent esp. for capillary blood sampling (heavy metal free)
Sample vials 1.5 ml with purple cap
Printerpaper
Thermocult Incubator (37 °C)
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
20 sets
20 pcs.
20 pcs.
1000 pcs.
2000 ml
1000 pcs.
10 rolls
1 pce.
1 pce.
1 pce.
10 pcs.
11080
11081
11082
ClinChek® Controls:
Hemolysate Control, Level I, ready for use
Hemolysate Control, Level II, ready for use
Hemolysate Control, Level I, II, ready for use
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
11020
1 set
vial with Hemolysis Reagent H
➜
➜ Column lifetime:
> 1000 analyses
HPLC Analysis:
1.61
0.39
0.55
0
0.76
5
5
Retention Time (min)
Test Data
Linearity: The test is linear over the whole range of
physiologically occurring HbA1c values (approx. 3 16 % HbA1c).
Intraassay precision: 1 - 2 %
Interassay precision: 2 - 3 %
1.03
15
0.40
0.55
0.75
Hemoglobin A1c
(HbA1c) in Whole
Blood (for VariantTM
and Modular HPLC)
20%
1.61
20%
ClinChek® Hemolysate Control, Level II
Intensity
Diabetes, Hemoglobin Testing
Intensity
This RECIPE HbA1c test kit is designed for the
application with the analyser VariantTM. However, the
kit can also be used with any conventional modular
HPLC system.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 50
incubate (24 h,
ambient temperature)
Inject 20 μl
VARIANTTM is a registerd trademark of BioRad
51
40
30
30
10
0
3.72
4.71
20
1.58
2.01
4.71
20
10
0
0
1
2
3
4
5
6
7
0
Retention Time (min)
Test Data
Intraassay precision: 1.0
0.6
Interassay precision: 2.1
0.7
-
3.3
3.6
2.8
2.4
% (HbF)
% (HbA2)
% (HbF)
(HbA2)
Dependence on total hemoglobin:
The HbF and HbA2 values are independent on the
amount of total hemoglobin in a range from 6 - 24
g/dl total hemoglobin.
HPLC Parameters
Pump:
Flow rate:
Injection volume:
Injection interval:
UV/VIS-Detector:
HPLC-Thermostat:
binary gradient pump
1.2 ml/min
20 μl
8 min
415 nm
23 °C
HbA1c: 1.59 min, HbF: 2.03 min, HbA0: 3.74 min,
HbA2: 4.71 min
Hemolysis:
5 μl venous blood
➜
HPLC Analysis:
1 ml Hemolysis Reagent H
2
3
4
5
6
7
Retention Time (min)
HbA1c: 1.58 min, HbF: 2.01 min, HbA0: 3.72 min,
HbA2: 4.71, HbS: 5.52 min
Order No.
Description
Quantity
13100
ClinRep® Complete Kit for Hemoglobin Variants and ß-Thalassemia Screening
in Whole Blood for 500 assays
1 pce.
Components of the Complete Kit (order no. 13100):
ClinRep® Reagent Kit
Hemolysate Calibrator HbF/A2, ready for use
Analytical Column with test chromatogram
Manual
Quick Reference
1
5
1
1
1
13107
13108
13109
13121
Components of the Reagent Kit (order no. 13101):
Buffer 1
Buffer 2
W Washing Solution
H Hemolysis Reagent
2500 ml
2500 ml
2000 ml
500 ml
13114
Optional Components:
Test Solution (HbA1c/F/A/E/A2/D/S/C), ready for use
5 x 3 ml
11024
FK5810
FK5820
FK5821
Accessories:
Sample vials 1.5 ml without cap
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1000 pcs.
1 pce.
1 pce.
10 pcs.
13182
13183
ClinChek® Controls:
Hemolysate Control HbF/A2, Level I, II, ready for use
Hemolysate Control HbF/A2/S, Level I, ready for use
2 x 5 x 3 ml
5 x 3 ml
13101
13113
13130
incubate (10 min, ambient temp.)
Inject 20 μl
1
Ordering Information
Sample Preparation
➜ Reliable separation
and quantification of
HbA2 and HbF
40
1.59
2.03
Hemoglobin Variants
and β-Thalassemia
Screening in
Whole Blood
50
3.74
50
ClinCheck® Hemolysate Control (HbF/A2/S), Level I
5.52
ClinCal® Hemolysate Calibrator (HbF/A2)
Intensity (mV)
Diabetes, Hemoglobin Testing
Intensity (mV)
Defects in genes, which are responsible for the synthesis of the hemoglobin molecule, result in a group
of hereditary diseases termed as ”hemoglobinopathies”. Depending on the molecular defect, hemoglobinopathies may be classified in ”structural hemoglobin variants” and in ”thalassemias”. This test
kit allows for a reliable separation and identification
of the common and clinically significant hemoglobin
variants. For ß-thalassemia screening the kit ensures
an exact quantification of HbF and HbA2. A readyto-use test solution (containing: HbA1c, HbF, HbA0,
HbE, HbA2, HbD, HbS, HbC), a hemolysate calibrator (containing: HbF, HbA2) as well as hemolysate
controls in two levels of concentration are available
for quality assurance.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 52
pce.
x 3 ml
pce.
pce.
pce.
➜ Safe identification of HbS,
HbC, HbE and HbD
➜ Test solution, calibrator
and control materials
available
53
5-Aminolevulinic acid (5-ALA) and porphobilinogen
(PBG) are intermediates in the biosynthesis of heme
and hemoglobin. In certain diseases, so-called porphyrias, an accumulation of 5-ALA and PBG is
observed due to abnormalities in the heme production. Porphyrias may be genetically predetermined
(hereditary porphyrias), or may be induced by different external factors, mostly by lead intoxication.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 54
Metabolic Diseases
5-Aminolevulinic Acid /
Porphobilinogen in
Urine
Test Data
Linearity:
Recovery:
LLOD:
LLOQ:
Intraassay precision:
0.8 - 80 mg/l
> 90 %
0.6 mg/l
0.8 mg/l
5-ALA: 3.4 %
PBG: 5.2 %
Interassay precision: 5-ALA: 4.6 %
PBG: 6.4 %
Sample Preparation
Extraction:
Apply 0.5 ml urine to a conditioned
5-ALA / PBG double column
➜
wash (3 x 10 ml HPLC water)
Separate the double column
Colourless column: ➜ A: Sample Preparation for 5-ALA
Blue column: ➜ B: Sample Preparation for PBG
Ordering Information
Order No.
Description
Quantity
17200
ClinRep® Complete Kit for 5-Aminolevulinic Acid and Porphobilinogen in Urine
for 50 assays
1 pce.
A: Sample Preparation for 5-ALA
Elution:
Elute with 7.0 ml Reagent A (receiver tube: 500 μl Reagent B)
➜
Derivatisation:
collect the eluate
17220
17320
17221
17222
17223
17224
1. Incubate at 100 °C (water bath, 10 min)
2. Add 7.0 ml Ehrlichʼs Reagent
3. Incubate at room temperature (15 min)
17300
➜
➜ Cost-efficient quick test
Analysis:
Photometric measurement
➜ Easy handling
B: Sample Preparation for PBG
Kit Components (order no 17200):
Sample Preparation Columns for 5-ALA
Sample Preparation Columns for PBG
Reagent A
Reagent B
Reagent C
Reagent D
Manual
Quick Reference
ClinRep® Complete Kit for Porphobilinogen in Urine
for 50 assays
50 pcs.
50 pcs.
500 ml
50 ml
2 x 17223 (2 x 7.5 g)
200 ml
1 pce.
1 pce.
1 pce.
Kit Components (order no 17300):
Sample Preparation Columns for PBG
Reagent C
Reagent D
Manual
Quick Reference
50 pcs.
7.5 g
200 ml
1 pce.
1 pce.
17260
FK6300
Accessories:
Column Rack (for 20 columns)
Reagent tube (100 x 16 mm) with screw cap and o-ring, PP, autoclavable up to 121 °C
1 pce.
50 pcs.
17213
ClinCal® Calibrator:
Urine Calibrator, lyophil.
5 x 5 ml
17280
17281
17282
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
17320
17223
17224
Elution:
Elute with 4.0 ml Reagent D
Derivatisation:
➜
➜ Reliable test results
collect the eluate
1. Add 4.0 ml Ehrlichʼs Reagent
2. Incubate at room temperature (15 min)
➜
Analysis:
Photometric measurement
55
Test Data
Linearity:
1 - 100 μmol/l
Recovery:
95 - 105 %
LLOD:
0.5 μmol/l
LLOQ:
1 μmol/l
Intraassay precision: 3.9 %
Interassay precision: 5.8 %
50 μl supernatant
HPLC Analysis:
➜
➜ Reliable sample
preparation (specific
derivatisation reagent)
centrifuge
100 μl Reagent C
3
4
3.31
0
5
1
2
3
4
5
Retention Time (min)
Cysteine: 2.10 min, IS: 2.47 min, Cysteinylglycine: 2.85 min,
Homocysteine: 3.31 min
Cysteine: 2.11 min, IS: 2.48 min, Cysteinylglycine: 2.85 min,
Homocysteine: 3.31 min
Order No.
Description
Quantity
23000
ClinRep® Complete Kit for Homocysteine in Plasma for 100 assays
1 pce.
Kit Components (order no. 23000):
Mobile Phase
Standard Solution
IS Internal Standard
Plasma Calibrator, lyophil.
Sample Preparation Vials
Reagent A
Reagent B
Reagent C
Reagent D
Manual
Quick Reference
1000 ml
3 ml
3 ml
3 ml
100 pcs.
3 ml
10 ml
10 ml
5 ml
1 pce.
1 pce.
23030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
23060
FK5810
FK5820
FK5821
Accessories:
250 μl derivatisation vial with cap (PE)
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
50 pcs.
1 pce.
1 pce.
10 pcs.
23080
23081
23082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
23010
23011
23012
23013
23020
23021
23022
23023
23024
25 μl Reagent A
100 μl Reagent B
➜
Derivatisation:
2
Retention Time (min)
➜
150 μl reduced sample
1
Ordering Information
Sample Preparation
Precipitation:
100
0
0
Reduction:
25 μl Internal
Standard IS
3.31
100
200
0
HPLC Parameters
Pump:
isocratic pump, flow rate:
1.0 ml/min
Injection volume:
20 μl
Injection interval:
5 min
Fluorescence
detector:
385 nm (exc.), 515 nm (em.)
HPLC-Thermostat: 30 °C
100 μl plasma
Intensity (mV)
200
2.85
300
2.11
300
2.85
400
2.47
400
2.10
Homocysteine
in Plasma
ClinChek® Plasma Control, Level II
2.48
ClinChek® Plasma Control, Level I
Metabolic Diseases
Intensity (mV)
Homocysteine is an established marker to estimate
the risk towards atherosclerosis and coronary heart
disease. An elevated plasma homocysteine level
(hyperhomocysteinemia), whether due to nutrient
deficiencies or by genetic defects, can be reduced
by intake of folic acid, vitamin B6 and B12. Therefore, the determination of homocysteine does not
only serve for the risk assessment towards atherosclerotic affections but also to ensure the proper
combination and dosage of a nutrition supplement
therapy. The RECIPE test kit allows for the simultaneous analysis of total homocysteine (tHcys) and
total cysteine (tCys).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 56
50 μl Reagent D
incubate (60 min, 60 °C)
Inject 20 μl
➜ Injection interval: 5 min
57
ClinChek® Urine Control, Level I
Test Data
Linearity:
5 - 170 mg/l
Recovery:
90 - 100 %
LLOD:
3 mg/l
LLOQ:
5 mg/l
Intraassay precision: 3.5 %
Interassay precision: 4.5 %
➜
➜
Complete sample
HPLC Analysis:
3.20
5.10
Intensity (mV)
0
1
2
3
4
5
0
6
1
2
3
4
5
6
Retention Time (min)
Hydroxyproline: 3.20 min, IS: 5.10 min
Order No.
Description
Quantity
16000
ClinRep® Complete Kit for Hydroxyproline in Urine for 100 assays
1 pce.
Kit Components (order no 16000):
Mobile Phase A
Mobile Phase B
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Hydrolysis Tubes with caps
pH - Test Stripes
Reagent A
Reagent B
Reagent C
Reagent D
Reagent E
Manual
Quick Reference
1000 ml
150 ml
5 ml
10 ml
5 x 8 ml
100 pcs.
100 pcs.
30 ml
80 ml
80 ml
2 x 16025 (2 x 50 mg)
20 ml
1 pce.
1 pce.
16030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
16031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
8820
8821
8822
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 8 ml
10 x 8 ml
2 x 5 x 8 ml
16008
16009
16011
16012
16013
16020
16021
16022
16023
16024
16025
16026
1 ml HCl
incubate (16 h, 95 °C)
incubate (10 min, 70 °C)
500 μl Mobile Phase A
Inject 20 μl
➜ Injection interval: 8 min
3
Ordering Information
➜
➜ High analytical selectivity
3
Hydroxyproline: 3.20 min, IS: 5.10 min
1. 100 μl sample + 300 μl Reagent A + 800 μl Reagent B / C
2. 500 μl sample + 200 μl Reagent D
3. 150 μl sample + 200 μl Reagent E
Dilution:
6
Retention Time (min)
Hydrolysis:
Derivatisation:
6
0
Sample Preparation
100 μl Internal
Standard IS
9
0
HPLC Parameters
Pump:
binary gradient pump,
flow rates: 1.2, 1.4 ml/min
Injection volume:
20 μl
Injection interval:
8 min
UV/VIS-Detector:
471 nm
HPLC-Thermostat: 60 °C
1 ml urine
9
5.10
Hydroxyproline
in Urine
ClinChek® Urine Control, Level II
3.20
Metabolic Diseases
Intensity (mV)
Osteoporosis is a metabolic bone disease which is
characterised by an abnormally low bone density
and therefore is associated with an increased risk
of fracture. The bone degradation goes along with
an increased formation of the amino acid hydroxyproline, which is released into blood circulation and is
excreted with urine. The RECIPE test kit guarantees
an accurate hydroxyproline measurement. Using a
special sample preparation, hydroxyproline is turned
into a derivative and can be quantified without interferences from other amino acids.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 58
➜ Reliable determination
59
Test Data
Linearity:
1 - 5000 μg/l
LLOD:
0.5 μg/l
LLOQ:
1 μg/l
Intraassay precision: 2.3 %
Interassay precision: 2.6 %
HPLC Parameters
Pump:
binary gradient pump,
flow rate: 0.7 ml/min
Injection volume:
20 μl
Injection interval:
20 min
Fluorescence
detector:
394 nm (exc.), 624 nm (em.)
HPLC-Thermostat: 30 °C
Sample Pretreatment
➜
HPLC Analysis:
12.68
0
12.67
11.37
20
8.86
9.55
5.16
40
7.53
9.55
5
7.54
10
60
6.28
Intensity (mV)
11.39
15
0
0
2
4
6
8
10
12
14
16
18
20
0
Retention Time (min)
Uroporphyrin I: 5.19 min, Heptacarboxyporphyrin I: 6.31 min,
Hexacarboxyporphyrins (Iac and Iab Isomer): 7.54 min,
Internal Standard IS: 8.86 min, Pentacarboxyporphyrin I: 9.55 min,
Coproporphyrin I: 11.39 min, Coproporphyrin III: 12.68 min
2
4
6
8
10
12
14
16
18
20
Retention Time (min)
Uroporphyrin I: 5.16 min, Heptacarboxyporphyrin I: 6.28 min,
Hexacarboxyporphyrins (Iac and Iab Isomer): 7.53 min,
Internal Standard IS: 8.86 min, Pentacarboxyporphyrin I: 9.55 min,
Coproporphyrin I: 11.37 min, Coproporphyrin III: 12.67 min
Ordering Information
Order No.
Description
Quantity
17000
ClinRep® Complete Kit for Porphyrins in Urine for 100 assays
1 pce.
Kit Components (order no. 17000):
Mobile Phase A
Mobile Phase B
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Vials for Sample Pretreatment
Manual
Quick Reference
2 x 17008 (2 x 1000 ml)
800 ml
5 ml
5 ml
5 x 5 ml
100 pcs.
1 pce.
1 pce.
17030
17032
17033
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
Guard Column
1 pce.
1 pce.
5 pcs.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
17080
17081
17082
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
17008
17009
17011
17012
17013
17020
Inject 20 μl of the supernatant
➜ High resolution of the
porphyrin profile
80
8.86
20
50 μl
Internal Standard IS
centrifuge
100
25
Addition of IS:
500 μl urine
(calibrator, control, patient)
ClinChek® Urine Control, Level II
30
5.19
Porphyrins
Differentiated in Urine
ClinChek® Urine Control, Level I
6.31
Metabolic Diseases
Intensity (mV)
The porphyrin excretion profile is used for the diagnosis of porphyrias. This ClinRep® Complete Kit
allows for a separation (differentiation) of the urinary porphyrins with high resolution (in different
porhyrin-isomers!) and ensures an exact quantification. For sample pretreatment, the samples simply have to be spiked with an internal standard and
centrifuged. As ”quick tests” for the screening of
porphyrias a column test for the determination of
the total porphyrins (see pages 62 - 63) as well as
a column test for the determination of 5-aminolevulinic acid and porphobilinogen are available (see
pages 54 - 55).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 60
➜ No interferences
➜ High analytical sensitivity
61
The determination of the urinary total porphyrins
serves for the basic diagnosis of suspected porphyrias. With this ”quick test” (no HPLC method)
the porphyrin quantification is performed by photometric measurement. For the analysis of the differentiated porphyrin profile a complete kit for HPLC
is provided (see pages 60 - 61).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 62
Metabolic Diseases
Total Porphyrins
in Urine
Test Data
Linearity:
20 - 4000 μg/l
Recovery:
~ 70 %
LLOD:
15 μg/l
LLOQ:
20 μg/l
Intraassay precision: 5.5 %
Interassay precision: 7.2 %
Sample Preparation
Extraction:
Ordering Information
Apply 1.0 ml urine to a conditioned
sample preparation column
➜
Elution:
wash (10 ml HPLC water)
Elute with 2.0 ml Eluting Reagent E
➜
Analysis:
Order No.
Description
Quantity
17100
ClinRep® Complete Kit for Porphyrins in Urine for 50 assays
1 pce.
Kit Components (order no. 17100):
Sample Preparation Columns
E Eluting Reagent
Manual
Quick Reference
50 pcs.
200 ml
1 pce.
1 pce.
FK4000
Accessories:
Column Rack (for 20 columns)
1 pce.
17280
17281
17282
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
17120
17121
collect the eluate
Photometric measurement
➜ Quick test for
total porphyrins
➜ Easy handling
➜ Low price per test
63
Test Data
On request
0.000
Retention Time (min)
IS: 3.55 min, α-Carotene: 7.79 min, all-trans-ß-Carotene:
8.43 min, 9-cis-ß-Carotene: 9.23 min, 13-cis-ß-Carotene:
9.76 min
➜
HPLC Analysis:
100 μl Stabilising
Reagent S
mix, centrifuge
Retention Time (min)
IS: 3.55 min, α-Carotene: 7.81 min, all-trans-ß-Carotene:
8.43 min, 9-cis-ß-Carotene: 9.23 min, 13-cis-ß-Carotene:
9.76 min
Order No.
Description
Quantity
30000
ClinRep® Complete Kit for ß-Carotene in Plasma / Serum
for 100 assays
1 pce.
Kit Components (order no. 30000):
Mobile Phase
P Precipitant with IS Internal Standard
Plasma Calibrator, lyophil.
Test Solution, lyophil.
Sample Preparation Vials
S Stabilising Reagent
Manual
Quick Reference
1000 ml
20 ml
5 x 0.5 ml
3 ml
100 pcs.
10 ml
1 pce.
1 pce.
30030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
30080
30081
30082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
Precipitation:
200 μl Precipitant P
(contains IS)
0 1 2 3 4 5 6 7 8 9 10
Ordering Information
Sample Preparation
100 μl sample
8.43
0.000
0 1 2 3 4 5 6 7 8 9 10
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.1 ml/min
Injection volume:
100 μl
Injection interval:
10 min
UV-Detector:
450 nm
HPLC-Thermostat: 30 °C
0.005
7.81
7.79
0.005
Intensity (mV)
8.43
0.010
9.23
9.76
0.010
3.55
0.015
9.23
9.76
β-Carotene
in Plasma / Serum
0.015
ClinChek® Plasma Control, Level II
3.55
ClinChek® Plasma Control, Level I
Oxidative Stress
Intensity (mV)
β-Carotene belongs to the group of the so-called
carotenoids. These compounds are part of the antioxidant defense system within the human organism
and are protecting cells and tissues from oxidative
damage (oxidative stress). All-trans-β-carotene is
the quantitatively most important carotenoid in our
diet, in human blood and tissues. The RECIPE
ClinRep® Complete Kit for β-Carotene provides a
unique chromatographical performance. Even the
cis-isomers of β-Carotene (9-cis-β-Carotene, 13-cisβ-Carotene) are base line separated. Prior to HPLC
analysis a simple two-step sample preparation
(precipitaton, stabilisation) is required.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 64
30010
30012
30013
30014
30020
30021
Inject 100 μl
➜ Simple two-step
sample preparation
➜ Excellent chromatographic
performance (separation of
cis isomers)
➜ Injection interval: 10 min
65
ClinChek® Plasma Control, Level I
1,0
0,5
0,0
HPLC Parameters
Pump:
isocratic pump, flow rate:
1.4 ml/min
Injection volume:
30 μl
Injection interval:
14 min
UV-Detector:
275 nm
HPLC-Thermostat: 30 °C
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Retention Time (min)
IS: 7.34 min, CoQ10: 11.54 min
Retention Time (min)
IS: 7.32 min, CoQ10: 11.49 min
Ordering Information
Order No.
Description
Quantity
31000
ClinRep® Complete Kit for Coenzyme Q10 in Whole Blood / Plasma / Serum
for 100 assays
1 pce.
Kit Components (order no. 31000):
Mobile Phase
IS Internal Standard
Plasma Calibrator, lyophil.
Test Solution
Sample Preparation Vials
P Precipitant
O Oxidation Reagent
Manual
Quick Reference
1000 ml
40 ml
5 x 2 ml
3 ml
100 pcs.
50 ml
5 ml
1 pce.
1 pce.
31030
31032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
31033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
31080
31081
31082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
31010
31012
31013
31014
31020
31021
31022
Sample Preparation
Precipitation:
0,5
0,0
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14
Test Data
Linearity:
38.9 - 20000 μg/l
Recovery:
94 - 108 %
LLOD:
19.5 μg/l
LLOQ:
38.9 μg/l
Intraassay precision: 3.4 %
Interassay precision: 5.0 %
11.49
1,0
7.32
1,5
Intensity (mV)
1,5
11.54
Coenzyme Q10
in Whole Blood /
Plasma / Serum
ClinChek® Plasma Control, Level II
7.34
Oxidative Stress
Intensity (mV)
Coenzyme Q10 (CoQ10) plays an outstanding role
in the energy production within the cell metabolism.
In addition, CoQ10 is an important antioxidant and
thus protects the cell from radical oxidation (oxidative stress). Lowered blood concentrations of CoQ10
seem to be connected with a number of diseases,
mainly cardiovascular diseases. The RECIPE
ClinRep® Complete Kit allows for a reliable determination of CoQ10 in whole blood, plasma, and
serum. After a quick sample preparation, the analytical chromatography is performed with an isocratic
HPLC system and UV detection. For quality assurance reference materials (ClinTest® Test Solution,
ClinCal® Plasma Calibrator and ClinChek® Plasma
Controls) with excellent stability are available.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 66
500 μl Precipitant P
➜
1. Add 400 μl sample
2. Add 50 μl Oxidation Reagent O
➜
Add 400 μl Internal Standard IS
HPLC Analysis:
➜
➜ Reliable sample
preparation
mix
mix, centrifuge
Inject 30 μl of the supernatant
➜ Reference materials
with excellent stability
available
67
ClinChek® Plasma Control, Level I
35
30
30
25
25
20
20
15
10
5
0
-5
Test Data
Linearity:
0.04 - 20 μmol/l
Recovery:
100 %
LLOD:
0.02 μmol/l
LLOQ:
0.04 μmol/l
Intraassay precision: 3.7 %
Interassay precision: 7.4 %
200 μl
Reagent B
➜
incubate (60 min, 100 °C)
➜
➜ Reliable sample
preparation
200 μl
Reagent C
centrifuge
1,0
1,5
2,0
2,5
3,0
3,5
4,0
4,5
5,0
0
0,5
1,0
1,5
2,0
2,5
3,0
3,5
4,0
4,5
5,0
Retention Time (min)
Malondialdehyde: 2.75 min
Ordering Information
Neutralisation / Precipitation:
HPLC Analysis:
0,5
Malondialdehyde: 2.75 min
Derivatisation:
200 μl
sample
5
0
Retention Time (min)
Order No.
Description
Quantity
32000
ClinRep® Complete Kit for Malondialdehyde in Plasma / Serum for 100 assays
1 pce.
Kit Components (order no. 32000):
Mobile Phase
Plasma Calibrator, lyophil.
Derivatisation Vials
Sample Preparation Vials
Reagent A
Reagent B
Reagent C
Manual
Quick Reference
1000 ml
5 x 0.5 ml
100 pcs.
100 pcs.
70 ml
20 ml
20 ml
1 pce.
1 pce.
32030
32031
FK7000
Start Accessories:
Analytical Column with test chromatogram
Guard Column
manu-CART® cartridgeholder, one time accessory
1 pce.
5 pcs.
1 set
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
32080
32081
32082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 0.5 ml
10 x 0.5 ml
2 x 5 x 0.5 ml
32010
32013
32020
32021
32022
32023
32024
Sample Preparation
700 μl
Reagent A
15
10
-5
0
HPLC Parameters
Pump:
isocratic pump, flow rate:
0.8 ml/min
Injection volume:
20 μl
Injection interval:
5 min
Fluorescence
detector:
515 nm (exc.), 553 nm (em.)
HPLC-Thermostat: 30 °C
100 μl
sample
2.75
35
Intensity (mV)
Malondialdehyde
in Plasma / Serum
ClinChek® Plasma Control, Level II
2.75
Oxidative Stress
Intensity (mV)
Malondialdehyde is formed by radical mediated lipid
peroxidation (oxidative stress) and shows mutagenic and cytotoxics effects by further reaction with
DNA. For this reason, malondialdehyde is considered
a suitable biomarker for the determination of oxidative stress. The RECIPE ClinRep® Complete Kit
allows for the reliable quantification of malondialdehyde from plasma and serum. For quality assurance a ClinCal® Plasma Calibrator and ClinChek®
Plasma Controls in two levels are available.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 68
Inject 20 μl of the supernatant
➜ Robust chromatography
➜ Injection interval: 5 min
69
ClinChek® Serum Control, Level I
ClinChek® Serum Control, Level II
60
Intensity (mV)
60
40
1.79
Test Data
Linearity:
0.5 - 300 mg/l
Recovery:
95 - 100 %
LLOD:
0.1 mg/l
LLOQ:
0.5 mg/l
Intraassay precision: 5.9 %
Interassay precision: 6.9 %
4.04
Vitamin C in Plasma
80
4.03
80
1.79
Oxidative Stress
Intensity (mV)
Vitamin C (ascorbic acid) is a potential scavenger
to radicals and oxidants. The exposure to these species is termed as ”oxidative stress”. Oxidative stress
is believed to contribute to the development of various
chronic diseases such as cardiovascular disease,
diabetes, and cancer. An inadequate vitamin C status
is usually observed in cases of malnutrition, smoking,
alcohol abuse, chronic toxications and stress. Also,
nursing women and elderly people are in danger of
a low vitamin C status. The RECIPE test kit features
fast analysis (quick sample preparation, short run
time) and ensures reliable results.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:32 Seite 70
20
0
40
20
0
0
1
2
3
4
5
0
Retention Time (min)
Vitamin C: 1.79 min, IS: 4.04 min
1
2
3
4
5
Retention Time (min)
Vitamin C: 1.79 min, IS: 4.03 min
Ordering Information
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.3 ml/min
Injection volume:
20 μl
Injection interval:
5 min
UV-Detector:
243 nm
HPLC-Thermostat: 30 °C
Order No.
Description
Quantity
28000
ClinRep® Complete Kit for Vitamin C in Plasma for 100 assays
1 pce.
Kit Components (order no. 28000):
Mobile Phase
P Precipitant with Internal Standard IS, lyophil.
Serum Calibrator, lyophil.
Test Solution, lyophil.
R Reconstitution Solution
Sample Preparation Vials
Manual
Quick Reference
1000 ml
5 x 3 ml
5 x 0.5 ml
5 x 1 ml
25 ml
100 pcs.
1 pce.
1 pce.
28030
28032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
28033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
28080
28081
28082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 0.5 ml
10 x 0.5 ml
2 x 5 x 0.5 ml
28010
28012
28013
28014
28015
28020
Sample Preparation
Precipitation:
100 μl Precipitant P
(contains Internal Standard IS)
100 μl sample
➜
1. incubate (10 min, + 4°C)
2. centrifuge
HPLC Analysis:
Inject 20 μl of the supernatant
➜ Quick sample preparation
➜ Injection interval: 5 min
➜ Reference materials
with excellent stability
available
71
ClinChek® Serum Control, Level I
5
7.20
3
2
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.5 ml/min
Injection volume:
50 μl
Injection interval:
8 min
UV-Detector:
325 / 295 nm
HPLC-Thermostat: 30 °C
2
0
0
Vitamin A:
0.02 - 5.0 mg/l,
Vitamin E:
0.40 - 50 mg/l
Recovery:
92 - 98 %
LLOD:
Vitamin A: 0.01 mg/l,
Vitamin E: 0.30 mg/l
LLOQ:
Vitamin A: 0.02 mg/l,
Vitamin E: 0.40 mg/l
Intraassay precision: Vitamin A: 1.4 %,
Vitamin E: 1.4 %
Interassay precision: Vitamin A: 5.0 %,
Vitamin E: 3.2 %
3
1
1
Test Data
Linearity:
4
7.19
Intensity (mV)
4
4.91
6
5
1.82
7
6
4.91
Vitamin A and E
in Plasma
ClinChek® Serum Control, Level II
7
1.82
Vitamin Status
Intensity (mV)
Vitamin A (retinol) and vitamin E (α-tocopherol) belong to the fat soluble class of vitamins. In contrast to
water soluble vitamins, an excessive administration
may lead to hypervitaminosis. Vitamin A deficiency
is the leading cause of preventable blindness in
children and raises the risk of disease and death
from severe infections. Vitamin E is an important
antioxidant and is thought to have a role in preventing atherosclerosis by inhibiting oxidation of lowdensity lipoprotein (LDL). The RECIPE ClinRep®
Complete Kit allows for the simultaneous analysis
of both vitamins within a run time of 8 min. For quality assurance, reference materials with excellent
stability are available.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 72
0
1
2
3
4
5
6
7
8
0
Retention Time (min)
1
2
3
4
5
6
7
8
Retention Time (min)
Vitamin A: 1.82 min, IS: 4.91 min, Vitamin E: 7.20 min
Vitamin A: 1.82 min, IS: 4.91 min, Vitamin E: 7.19 min
Ordering Information
Order No.
Description
Quantity
22000
ClinRep® Complete Kit for Vitamin A and E in Plasma for 100 assays
1 pce.
Kit components (order no. 22000):
Mobile Phase
Standard Solution
P Precipitant with Internal Standard IS
Serum Calibrator, lyophil.
Sample Preparation Vials with Reagent, lyophil.
Reaction Vials
S Stabilising Reagent
Manual
Quick Reference
1000 ml
3 ml
15 ml
3 ml
2 x 22020 (2 x 50 pcs.)
100 pcs.
10 ml
1 pce.
1 pce.
22030
FK7000
Start Accessories:
Analytical Column with test chromatogram
manu-CART® cartridgeholder, one time accessory
1 pce.
1 set
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
8870
8871
8872
8873
ClinChek® Controls:
Serum Control, lyophil.,
Serum Control, lyophil.,
Serum Control, lyophil.,
Serum Control, lyophil.,
10 x 5 ml
10 x 5 ml
10 x 5 ml
3 x 3 x 5 ml
22010
22011
22012
22013
22020
22021
22022
Sample Preparation
Extraction:
150 μl plasma / serum
Stabilisation:
➜ Injection interval: 8 min
HPLC Analysis:
➜
➜ Quick sample preparation
150 μl Precipitant P
(contains Internal Standard IS)
100 μl
supernatant
Level
Level
Level
Level
I
II
III
I, II, III
centrifuge
100 μl
Stabilising Reagent S
➜
centrifuge
Inject 50 μl of the supernatant
➜ Reference materials
with excellent stability
available
73
ClinChek® Whole Blood Control, Level I
120
100
100
60
40
2
3
4
5
0
6
TPP: 2.52 min, Thiamine: 5.10 min
1
2
3
4
5
6
Retention Time (min)
TPP: 2.52 min, Thiamine: 5.09 min
Ordering Information
➜
2. take off 400 μl supernatant
Add 50 μl Reagent S
➜
50 μl Reagent C
➜
HPLC Analysis:
1
Retention Time (min)
Stabilisation:
450 μl sample
0
0
Order No.
Description
Quantity
24000
ClinRep® Complete Kit for Vitamin B1 in Whole Blood for 100 assays
1 pce.
Kit Components (order no. 24000):
Mobile Phase
Test Solution
Whole Blood Calibrator, lyophil.
Sample Preparation Vials
Reagent A
Reagent C
Reagent D
Reagent E
Reagent N
Reagent S
Manual
Quick Reference
1000 ml
3 ml
5 x 2 ml
2 x 24020 (2 x 100 pcs.)
50 ml
5 ml
10 ml
10 ml
250 ml
5 ml
1 pce.
1 pce.
27030
27032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
27033
FK2000
FK2001
FK5121
FK5810
FK5820
FK5821
Accessories:
Guard Column
ClinLab® Peristaltic pump
Replacement tubing for peristaltic pump
T-Union (PEEK), 1/16"
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
2 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
8874
8875
8876
ClinChek® Controls:
Whole Blood Control, lyophil., Level I
Whole Blood Control, lyophil., Level II
Whole Blood Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
24010
24014
24513
24020
24021
24023
24024
24025
24626
24027
500 μl Reagent A
1. centrifuge
Oxidation:
40
20
0
Sample Preparation
300 μl whole blood
80
60
5.09
80
2.52
140
120
5.10
Test Data
Determination as TPP
Linearity:
1 - 200 μg/l
Recovery:
95 - 100 %
LLOD:
0.5 μg/l
LLOQ:
1 μg/l
Intraassay precision: 2.7 %
Interassay precision: 4.2 %
Extraction:
➜ Injection interval: 4 min
160
140
20
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Pump (Reagent N): flow rate: 0.1 ml/min
Injection volume:
50 μl
Injection interval:
4 min
Fluorescence
detector:
376 nm (exc.), 435 nm (em.)
HPLC-Thermostat: 35 °C
➜ Excellent sensitivity:
0.5 μg/l
160
Intensity (mV)
Vitamin B1
in Whole Blood
ClinChek® Whole Blood Control, Level II
2.52
Vitamin Status
Intensity (mV)
Vitamin B1 (thiamine, thiamine pyrophosphate
(TPP)) acts as coenzyme in the carbohydrate metabolism and is essential for the normal functioning
of the organism. Deficiency mainly occurs in undernourished people, alcoholics or in special clinical
situations (e.g. hemodialysis). A fully developed
deficiency syndrome is called ”BeriBeri”. With this
RECIPE test kit, vitamin B1 is determined as TPP.
The kit can be combined in a convenient manner
with the test kits for vitamin B2 and B6 (see combi
kit, pages 80 - 81).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 74
100 μl Reagent D
add 100 μl Reagent E
Inject 50 μl of the supernatant
➜ Combinable with B2 and
B6 test kits
75
10
8
8
6
6
Test Data
Determination as FAD
Linearity:
20 - 500 μg/l
Recovery:
95 - 100 %
LLOD:
10 μg/l
LLOQ:
20 μg/l
Intraassay precision: 3.8 %
Interassay precision: 4.0 %
➜
1. add 500 μl Stabilising
Reagent S
HPLC Analysis:
2. centrifuge
Inject 50 μl of the supernatant
-2
0
1
2
3
4
5
6
7
8
9
10
0
1
2
3
4
5
6
Retention Time (min)
Retention Time (min)
Flavin adenine dinucleotide: 2.77 min,
Flavin mononucleotide: 5.20 min,
Riboflavin: 8.24 min
Flavin adenine dinucleotide: 2.77 min,
Flavin mononucleotide: 5.18 min,
Riboflavin: 8.26 min
7
8
9
10
Ordering Information
Order No.
Description
Quantity
25000
ClinRep® Complete Kit for Vitamin B2 in Whole Blood for 100 assays
1 pce.
Kit Components (order no. 25000):
Mobile Phase
Test Solution, lyophil.
R Reconstitution Solution
Whole Blood Calibrator, lyophil.
Sample Preparation Vials
P Precipitant
S Stabilising Reagent
Manual
Quick Reference
1000 ml
5 x 2 ml
10 ml
5 x 2 ml
100 pcs.
30 ml
50 ml
1 pce.
1 pce.
27030
27032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
27033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
8874
8875
8876
ClinChek® Controls:
Whole Blood Control, lyophil., Level I
Whole Blood Control, lyophil., Level II
Whole Blood Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
25010
25014
25015
24513
25020
25021
25022
Sample Preparation
300 μl Precipitation
Reagent P
2
0
-2
Extraction:
200 μl whole blood
8.26
8.24
5.20
2
4
5.18
4
0
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
50 μl
Injection interval:
10 min
Fluorescence
detector:
450 nm (exc.), 530 nm (em.)
HPLC-Thermostat: 40 °C
➜ Quick sample preparation
Intensity (mV)
10
2.77
Vitamin B2
in Whole Blood
ClinChek® Whole Blood Control, Level II
2.77
ClinChek® Whole Blood Control, Level I
Vitamin Status
Intensity (mV)
The term ”vitamin B2” covers three vitamers: riboflavin, flavin mononucleotide (FMN) and flavin
adenine dinucleotide (FAD). FMN and FAD are the
effective forms of vitamin B2 and are synthesised
in vivo from riboflavin by phosphorylation. Vitamin
B2 is important for energy production, enzyme functions as well as for the fatty acid and amino acid
synthesis. The undersupply with vitamin B2 is mostly attributed to a general malnutrition. It is often seen
in persons with risk factors such as alcohol problems, advanced age and extreme dietary habits.
The RECIPE test kit features short time for analysis
(easy sample preparation, short run time) and can
be easily combined with test kits for the vitamins
B1 and B6 (see combi kit, pages 80 - 81).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 76
➜ Injection interval: 10 min
➜ Combineable with B1 and
B6 test kits
77
➜ Excellent sensitivity:
0.4 μg/l
ClinChek® Whole Blood Control, Level I
Test Data
Determination from plasma / from whole blood
Linearity:
Pyridoxal:
0.6 - 800 μg/l /
0.6 - 1200 μg/l
Pyridoxal-5ʻ-phosphate: 0.6 800 μg/l /
0.6 - 1500 μg/l
Recovery:
95 - 100 % / 95 - 100 %
LLOD:
0.4 μg/l for both analytes and both matrizes
LLOQ:
0.6 μg/l for both analytes and both matrizes
Intraassay precision: Pyridoxal: 5.1 % / 8.4 %
Pyridoxal-5ʻ-phosphate:
2.5 % / 2.3 %
Interassay precision: Pyridoxal: 6.9 % / 9.2 %
Pyridoxal-5ʻ-phosphate:
3.1 % / 2.9 %
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Pump (Reagent N): flow rate: 0.2 ml/min
Injection volume:
50 μl
Injection interval:
10 min
Fluorescence
detector:
370 nm (exc.), 470 nm (em.)
Temperature:
25 °C (or ambient)
Sample Preparation
Extraction:
➜ Quick sample preparation
HPLC Analysis:
100 μl Precipitant P
➜
➜ Injection interval: 10 min
100 μl sample
10
8
8
4
2
6
8.82
Intensity (mV)
6
5.22
10
8.82
Vitamin B6 in Plasma /
Whole Blood
ClinChek® Whole Blood Control, Level II
5.24
Vitamin Status
Intensity (mV)
Vitamin B6 consists of three vitamers: pyridoxine,
pyridoxal and pyridoxamine. The metabolically active
coenzyme form of vitamin B6 is pyridoxal-5'-phosphate (PLP). Clinical signs of vitamin B6 deficiency
are mainly expressed in alterations of the skin,
neurological disorders, and anemias. In addition to
this, a low vitamin B6 status may be responsible for
an increase of the homocysteine plasma level (hyperhomocysteinemia, see pages 56 - 57, and 126 - 129).
The RECIPE ClinRep® Complete Kit allows for the
determination of the vitamin B6 forms pyridoxal and
PLP in plasma and whole blood. The test features
high analytical sensitivity and can be easily combined with the test kits for the vitamins B1 and B2
(see combi kit, pages 80 - 81).
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 78
4
2
0
0
0
1
2
3
4
5
6
7
8
9
10
0
1
2
Retention Time (min)
Pyridoxal-5ʼ-phosphate: 5.24 min, Pyridoxal: 8.82 min
3
4
5
6
7
8
9
10
Retention Time (min)
Pyridoxal-5ʼ-phosphate: 5.22 min, Pyridoxal: 8.82 min
Ordering Information
Order No.
Description
Quantity
26000
ClinRep® Complete Kit for Vitamin B6 in Plasma / Whole Blood for 100 assays
1 pce.
Kit Components (order no. 26000):
Mobile Phase
Standard Solution
Serum Calibrator, lyophil.
Sample Preparation Vials
P Precipitant
Reagent N
Manual
Quick Reference
1000 ml
3 ml
3 ml
100 pcs.
10 ml
250 ml
1 pce.
1 pce.
24513
Optional Components:
Whole Blood Calibrator, lyophil.
5 x 2 ml
27030
27032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
27033
FK2000
FK2001
FK5121
FK5810
FK5820
FK5821
Accessories:
Guard Column
ClinLab® Peristaltic pump
Replacement tubing for peristaltic pump
T-Union (PEEK), 1/16"
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
2 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
8870
8871
8872
8873
8874
8875
8876
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level III
Serum Control, lyophil., Level I, II, III
Whole Blood Control, lyophil., Level I
Whole Blood Control, lyophil., Level II
Whole Blood Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
10 x 5 ml
3 x 3 x 5 ml
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
26010
26011
26013
26020
26021
24626
centrifuge
Inject 50 μl of the supernatant
➜ Combineable with B1
and B2 test kits
79
Vitamin Status
Vitamin B1, B2 in
Whole Blood and
B6 in Plasma / Whole
Blood (Combikit)
Test Data
On request
HPLC Parameters
Pump (Mobile Phase A + B):
Pump (Reagent N):
Injection volume:
Injection interval:
HPLC-Thermostat:
Detector (exc. / em.):
Retention times:
Thiamine
TPP
HPLC Parameters
Pump (Mobile Phase A + B):
➜ High flexibility:
1 Chromatography kit
+ 3 sample preparation kits
Injection volume:
Injection interval:
HPLC-Thermostat:
Detector (exc. / em.):
Retention times:
Riboflavin
FMN
FAD
HPLC Parameters
Pump (Mobile Phase A + B):
Pump (Reagent N):
Injection volume:
Injection interval:
HPLC-Thermostat:
Detector (exc. / em.):
Retention times:
Pyridoxal
PLP
Vitamin B1
flow rate 1 ml/min
ratio A : B = 93 : 7
flow rate 0.1 ml/min
50 μl
6 min
35 °C
376 nm / 435 nm
approx. 5.1 min
approx. 2.5 min
Vitamin B2
flow rate 1 ml/min
ratio A : B = 80 : 20
50 μl
10 min
40 °C
450 nm / 530 nm
approx. 8.2 min
approx. 5.2 min
approx. 2.8 min
Vitamin B6
flow rate 1 ml/min
ratio A : B = 100 : 0
flow rate 0.2 ml/min
50 μl
10 min
25 °C
370 nm / 470 nm
Sample Preparation
Vitamin B1: see page 74, Vitamin B2: see page 76, Vitamin B6: see page 78
Chromatograms
See chromatograms on page 75 (Vitamin B1),
77 (Vitamin B2), and 79 (Vitamin B6)
Ordering Information The combi kit consists of the chromatography kit (order no. 27000) and the
separate sample preparation kits (order nos. 27001, 27002 and 27006).
A: Chromatography
Order No.
Description
Quantity
27000
ClinRep® Chromatography Kit for Vitamin B1, B2 and B6 for 1000 assays
1 pce.
Kit Components (order no. 27000):
Mobile Phase A
Mobile Phase B
Analytical Column with test chromatogram
Guard Column
Replacement filter for stainless steel prefilter holder
Manual
Quick Reference
4 x 27008 (4 x 2400 ml)
2 x 27009 (2 x 1000 ml)
1 pce.
5 pcs.
10 pcs.
1 pce.
1 pce.
27032
FK2000
FK2001
FK5121
FK5810
FK5820
FK5821
Accessories:
Guard Column Holder incl. 1 Guard Column
ClinLab® Peristaltic pump
Replacement tubing for peristaltic pump
T-Union (PEEK), 1/16"
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
2 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
8870
8871
8872
8873
8874
8875
8876
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level III
Serum Control, lyophil., Level I, II, III
Whole Blood Control, lyophil., Level I
Whole Blood Control, lyophil., Level II
Whole Blood Control, lyophil., Level I, II
10 x 5 ml
10 x 5 ml
10 x 5 ml
3 x 3 x 5 ml
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
27008
27009
27030
27033
FK5821
B: Sample Preparation
Order No.
Description
Quantity
27001
ClinRep® Sample Preparation Kit for Vitamin B1 in Whole Blood for 100 assays
Kit Components (order no. 27001):
Identical with order no. 24000 (s. page 75);
1 pce.
27002
ClinRep® Sample Preparation Kit for Vitamin B2 in Whole Blood for 100 assays
Kit Components (order no. 27002):
Identical with order no. 25000 (s. page 77);
1 pce.
27006
ClinRep® Sample Preparation Kit for Vitamin B6 in Plasma and Whole Blood for 100 assays
Kit Components (order no. 27006):
Identical with order no. 26000 (s. page 79);
1 pce.
}
exception: Mobile Phase
not included
The combi kit enables the combined measurement
of the vitamins B1, B2, and B6. It consists of the
chromatography kit (order no. 27000) and appropriate sample preparation kits (order nos. 27001,
27002, 27006). The chromatography is performed
with a single column for all B-vitamins in subsequent
series of measurement. For switching the parameter
(e.g. vitamin B1 --> vitamin B2) simply the parameter settings have to be changed (see HPLC
parameters). By selecting the appropriate sample
preparation kits, the customer is flexible to choose
the parameters according to his needs.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 80
approx. 8.8 min
approx. 5.2 min
81
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ClinChek® Serum Control, Level I
Sample Preparation
Precipitation:
500 μl Precipitant P
➜
1. Add 400 μl sample
2. Add 400 μl Internal Standard IS
➜
HPLC Analysis:
1
2
3
4
5
6
7
8
9
10
8.94
6.87
Intensity (mV)
0
1.0
0.5
7.83
8.94
0.5
0
3.0 - 500 μg/l (D2)
2.6 - 500 μg/l (D3)
Recovery:
99 - 104 %
LLOD:
1.1 μg/l (D2)
1.0 μg/l (D3)
LLOQ:
3.0 μg/l (D2)
2.6 μg/l (D3)
Intraassay precision: 2.7 % (D2)
2.5 % (D3)
Interassay precision: 3.7 % (D2)
3.7 % (D3)
1.5
1.0
Test Data
Linearity:
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
50 μl
Injection interval:
10 min
UV-Detector:
264 nm
HPLC-Thermostat: 40 °C
➜ Quick sample preparation
(no solid phase extraction
required)
1.5
6.89
25-OH Vitamin D2 / D3
in Plasma and Serum
ClinChek® Serum Control, Level II
7.84
Vitamin Status
Intensity (mV)
The determination of 25-OH vitamin D (i.e. D2, D3)
is used for the assessment of the vitamin D status.
The RECIPE HPLC complete kit enables a quick
and reliable quantification of both analytes from
plasma and serum. The sample preparation consists
of a simple precipitation step, a time consuming
solid phase extraction is not required. The subsequent HPLC analysis is performed with an injection
interval of 10 min only. For system check, calibration
and internal quality control a ClinTest® Test Solution,
a ClinCal® Serum Calibrator (traceable to NIST
standard SRM 972) and ClinChek® Serum Controls
are available.
Diagnostics
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 82
0
0
1
2
3
4
5
6
7
8
9
10
Retention Time (min)
Retention Time (min)
25-OH Vitamin D3: 6.89 min, 25-OH Vitamin D2: 7.84 min,
IS: 8.94 min
25-OH Vitamin D3: 6.87 min, 25-OH Vitamin D2: 7.83 min,
IS: 8.94 min
Ordering Information
Order No.
Description
Quantity
35000
ClinRep® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum for 100 assays
1 pce.
Kit Components (order no. 35000):
Mobile Phase
IS Internal Standard
Serum Calibrator, lyophil.
Test Solution, lyophil.
Sample Preparation Vials with Reagent, lyophil.
P Precipitant
Manual
Quick Reference
1000 ml
50 ml
5 x 2 ml
2 x 2 ml
100 pcs.
50 ml
1 pce.
1 pce.
35030
35032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
35033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
35080
35081
35082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
35010
35012
35013
35014
35020
35021
mix, centrifuge
Inject 50 μl of the supernatant
➜ Injection interval: 10 min
➜ Traceable to NIST
standard SRM 972
83
soon: autoe
l
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with liq
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aration
Additio
p
e
r
p
plates
sample
d well
n
a
s
mated
m
te
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handli
0.0006
0.0004
0.0000
UHPLC Parameters
Pump:
isocratic pump,
flow rate: 0.75 ml/min
Injection volume:
5 μl
Injection interval:
2 min
UV-Detector:
264 nm
HPLC-Thermostat: 40 °C
Sample Preparation
0.0006
0.0004
0.0000
0
4.6 - 500 μg/l (D2)
3.7 - 500 μg/l (D3)
Recovery:
99 - 104 %
LLOD:
2.8 μg/l (D2)
2.2 μg/l (D3)
LLOQ:
4.6 μg/l (D2)
3.7 μg/l (D3)
Intraassay precision: 4.3 % (D2)
4.6 % (D3)
Interassay precision: 5.9 % (D2)
3.9 % (D3)
0.0008
0.0002
0.0002
Test Data
Linearity:
1.57
0.0010
0.0008
0.77
0.0012
0.0010
Intensity (mV)
0.0014
0.0012
1.58
0.0016
0.0014
0.68
0.77
25-OH Vitamin D2 / D3
in Plasma and Serum
with UHPLC
0.0016
0.68
ClinChek® Serum Control, Level II
ClinChek® Serum Control, Level I
Vitamin Status
Intensity (AU)
25-OH Vitamin D (i.e. D2, D3) is an important parameter for the assessment of the vitamin D status.
In addition to RECIPE's HPLC complete kit (see
pages 82 - 83), a ClinRep® Complete Kit for UHPLC
systems is available. The RECIPE ClinRep® UHPLC
Complete Kit features a significantly increased sample throughput with reduced buffer consumption due
to the very short chromatography duration of only
2 minutes. For system check, calibration and internal quality control a ClinTest® Test Solution, a ClinCal®
Serum Calibrator (traceable to NIST standard SRM
972) and ClinChek® Serum Controls are available.
Diagnostics
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0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0
0
0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0
Retention Time (min)
Retention Time (min)
25-OH Vitamin D3: 0.68 min, 25-OH Vitamin D2: 0.77 min,
IS: 1.58 min
25-OH Vitamin D3: 0.68 min, 25-OH Vitamin D2: 0.77 min,
IS: 1.57 min
Ordering Information
Order No.
Description
Quantity
35100
ClinRep® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum with UHPLC
for 100 assays
1 pce.
Kit Components (order no. 35100):
Mobile Phase
IS Internal Standard
Serum Calibrator, lyophil.
Test Solution, lyophil.
Sample Preparation Vials
P Precipitant
Manual
Quick Reference
1000 ml
50 ml
5 x 2 ml
2 x 2 ml
100 pcs.
50 ml
1 pce.
1 pce.
35130
Start Accessories:
Analytical Column with test chromatogram
1 pce.
35080
35081
35082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
35010
35012
35013
35014
35020
35021
Precipitation:
500 μl Precipitant P
➜
➜ First UHPLC Kit for
Vitamin D
1. Add 400 μl sample
2. Add 400 μl Internal Standard IS
➜ Injection interval: 2 min
➜
UHPLC Analysis:
mix, centrifuge
Inject 10 μl of the supernatant
➜ Traceable to NIST
standard SRM 972
85
TDM
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 86
HPLC Complete Kits
ClinRep® TDM
for Therapeutic Drug Monitoring
Antiarrhythmics
Amiodarone in Plasma . . . . . . . . . . . . . 88 - 89
Antiasthmatics
Theophylline, Theobromine and
Caffeine in Plasma . . . . . . . . . . . . . . . . . 90 - 91
Antiepileptic Drugs
Antiepileptics in Serum . . . . . . . . . . . . . 92 - 93
Antiepileptics in Serum / Plasma,
advanced . . . . . . . . . . . . . . . . . . . . . . . . . 94 - 95
Antiepileptics in Serum / Plasma
with UHPLC . . . . . . . . . . . . . . . . . . . . . . . 96 - 97
Lamotrigine and Sulthiame
in Plasma . . . . . . . . . . . . . . . . . . . . . . . . 98 - 99
Levetiracetam (Keppra®)
in Serum / Plasma
– Manual sample preparation . . . . . . 100 - 101
– with Gilson® ASPEC™ . . . . . . . . . . 100 - 101
Immunosuppressants
Mycophenolic Acid in Plasma . . . . . . 102 - 103
Psychoactive Drugs
Atypical Neuroleptics in Plasma /
Serum – On-Line Analysis . . . . . . . . . 104 - 105
87
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Test Data
Linearity:
Recovery:
LLOD:
LLOQ:
Intraassay precision:
HPLC Parameters
Pump:
isocratic pump,
flow rate: 0.8 ml/min
Injection volume:
20 μl
Injection interval:
8 min
UV/VIS-Detector:
255 nm
HPLC-Thermostat: 30 °C
Sample Preparation
150 μl Precipitant P
(contains Internal Standard IS)
➜
centrifuge
Inject 20 μl of the supernatant
➜ Simple and quick sample
preparation
1
6.71
4.93
2
TDM
6.70
4
3
4.93
5
4
Intensity (mV)
5
3
2
1
0
0
1
2
3
4
5
6
7
0
8
Retention Time (min)
IS: 2.82 min, Desethylamiodarone: 4.93 min,
Amiodarone: 6.71 min
1
2
3
4
5
6
7
8
Retention Time (min)
IS: 2.82 min, Desethylamiodarone: 4.93 min,
Amiodarone: 6.70 min
Ordering Information
Order No.
Description
Quantity
20000
ClinRep® Complete Kit for Amiodarone in Plasma for 100 assays
1 pce.
Kit Components (order no. 20000):
Mobile Phase
Standard Solution
P Precipitant with Internal Standard
Serum Calibrator, lyophil.
Sample Preparation Vials with Reagent, lyophil.
Manual
Quick Reference
1000 ml
3 ml
15 ml
3 ml
2 x 20020 (2 x 50 pcs.)
1 pce.
1 pce.
20030
20032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
20031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
20033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
20080
20081
20082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
20010
20011
20012
20013
20020
Extraction:
HPLC Analysis:
6
0
0.1 - 10 μg/ml
95 - 105 %
0.07 μg/ml
0.1 μg/ml
Amiodarone: 2.1 %,
Desethylamiod.: 2.5 %
Interassay precision: Amiodarone: 4.0 %,
Desethylamiod.: 4.2 %
100 μl sample
6
2.82
Amiodarone
in Plasma
ClinChek® Serum Control, Level II
2.82
ClinChek® Serum Control, Level I
Antiarrhythmics
Intensity (mV)
Cardiac arrhythmias are major causes of morbidity
and mortality throughout the world. Arrhythmias
are controlled by medication of several drugs, such
as amiodarone, an antiarrhythmic agent that helps
to stabilise the normal rhythm of the heart. The resorption rate and the biological availability of amiodarone is low and extremely variable. The therapy
therefore requires a close monitoring for the adjustment of the drug dosage. The RECIPE ClinRep®
Complete Kit allows for a quick, sensitive and reliable determination of amiodarone and the main metabolite desethylamiodarone. The sample preparation
consists of a simple precipitation step.
➜ Linearity over a wide range
➜ Short run time
89
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5.83
5
1.3 - 50 mg/l
approx. 70 %
Theophylline: 0.8 mg/l
Theobromine: 0.6 mg/l
Caffeine: 0.6 mg/l
LLOQ:
Theophylline: 1.7 mg/l
Theobromine: 1.3 mg/l
Caffeine: 1.4 mg/l
Intraassay precision: 2.5 %
Interassay precision: 1.7 %
Sample Preparation
Extraction:
100 μl plasma
50 μl supernatant
1
2
3
4
5
6
7
8
TDM
5.85
0
1
Theobromine: 1.80 min, Theophylline: 2.66 min,
IS: 3.26 min, Caffeine: 5.83 min
2
3
4
5
6
7
8
Retention Time (min)
Theobromine: 1.83 min, Theophylline: 2.69 min,
IS: 3.29 min, Caffeine: 5.85 min
Ordering Information
Order No.
Description
Quantity
12000
ClinRep® Complete Kit for Theophylline, Theobromine and Caffeine in Plasma
for 100 assays
1 pce.
Kit Components (order no. 12000):
Mobile Phase
Standard Solution
P Precipitant with Internal Standard IS
Plasma Calibrator, lyophil.
Sample Preparation Vials with Reagent, lyophil.
D Diluting Solution
Manual
Quick Reference
1000 ml
4 ml
15 ml
3 ml
2 x 12020 (2 x 50 pcs.)
25 ml
1 pce.
1 pce.
12030
FK7000
Start Accessories:
Analytical Column with test chromatogram
manu-CART® cartridgeholder, one time accessory
1 pce.
1 set
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
12080
12081
12082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
12010
12011
12012
12013
12020
12021
250 μl Diluting Solution D
➜
HPLC Analysis:
centrifuge
5
Retention Time (min)
150 μl Precipitant P
(contains Internal Standard IS)
➜
Dilution:
10
0
0
Test Data
Linearity:
Recovery:
LLOD:
3.29
1.83
10
Intensity (mV)
2.66
15
0
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.5 ml/min
Injection volume:
20 μl
Injection interval:
8 min
UV/VIS-Detector:
273 nm
HPLC-Thermostat: 37 °C
➜ Simultaneous determination
of 3 methylxanthines
15
1.80
Theophylline,
Theobromine and
Caffeine in Plasma
20
3.26
20
ClinChek® Plasma Control, Level II
2.69
ClinChek® Plasma Control, Level I
Antiasthmatics
Intensity (mV)
Theophylline, theobromine and caffeine are termed
as methylxanthines and are used in the management of asthma bronchiale. Methylxanthines produce a relaxation of the bronchial smooth muscle
and thus are helping to open up constricted airways (bronchodilators). The drug absorption and
metabolism may be affected by many factors,
including co-medication with other drugs (e.g.
several AEDs, see pages 92 - 101). A monitoring of
the plasma level is therefore essential to ensure
that therapeutic, but not toxic drug doses are
applied. The RECIPE ClinRep® Complete Kit features simple and quick sample preparation, a costefficient analysis and ensures reliable results.
Inject 20 μl of the diluted supernatant
➜ Simple and quick sample
preparation
➜ Low cost per test
91
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* Carbamazepine,
carbamazepine-epoxide, N-desmethylmethsuximide, eslicarbazepine, ethosuximide, 10-hydroxycarbamazepine, lamotrigine, oxcarbazepine, PEMA, phenobarbital,
phenytoin, primidone, sulthiame
ClinChek® Serum Control, Level II, recorded at 205 nm:
160
Test Data
Linearity:
100 μl sample
150 μl Precipitant P
(contains Internal Standard IS)
➜
Dilution:
100 μl supernatant
100 μl Diluting Solution D
➜
HPLC Analysis:
centrifuge
Inject 10 μl of the diluted supernatant
TDM
1.90
Intensity (mV)
40
12.56
4.98
11.19
8.02
6.13
2.01
80
8
4
0
2
4
6
8
10
12
14
0
Retention Time (min)
PEMA: 1.39 min, Ethosuximide: 1.65 min, Primidone: 2.01 min,
10-Hydroxy-carbamazepine: 3.43 min, Phenobarbital: 3.83 min,
N-Desmethylmethsuximide: 4.25 min, Carbamazepine-epoxide:
4.98 min, Oxcarbazepine: 6.13 min, IS: 8.02 min, Phenytoin:
11.19 min, Carbamazepine: 12.56 min
2
4
6
8
10
Retention Time (min)
Sulthiame: 1.90 min, Lamotrigine: 2.74 min, IS: 8.00 min
Ordering Information
Order No.
Description
Quantity
15000
ClinRep® Complete Kit for Antiepileptics in Serum for 100 assays
1 pce.
Kit Components (order no. 15000):
Mobile Phase
Standard Solution Antiepileptics
P Precipitant with Internal Standard IS
Serum Calibrator Antiepileptics, lyophil.
Sample Preparation Vials with Reagent, lyophil.
D Diluting Solution
Manual
Quick Reference
1000 ml
3 ml
15 ml
3 ml
2 x 15020 (2 x 50 pcs.)
10 ml
1 pce.
1 pce.
15111
15113
Optional Components:
Standard Solution for Lamotrigine and Sulthiame
Plasma Calibrator for Lamotrigine and Sulthiame, lyophil.
3 ml
3 ml
15030
15032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
15031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
15033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
15080
15081
15082
15180
15181
15182
ClinChek® Controls:
Serum Control Antiepileptics, lyophil., Level I
Serum Control Antiepileptics, lyophil., Level II
Serum Control Antiepileptics, lyophil., Level I, II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
15010
15011
15012
15013
15020
15021
Extraction:
➜ Robust and fast
chromatography
(injection interval: 15 min)
3.43
3.83
12
0
Lamotrig., Sulthiame:
0.5 - 50 μg/ml
Other Antiepileptics:
0.3 - 300 μg/ml
Recovery:
95 - 105 %
LLOD:
Lamotrig., Sulthiame:
0.2 μg/ml
Other Antiepileptics:
0.1 μg/ml
LLOQ:
Lamotrig., Sulthiame:
0.5 μg/ml
Other Antiepileptics:
0.3 μg/ml
Intraassay precision: 2.3 %
Interassay precision: 2.8 %
Sample Preparation
➜ Efficient sample clean-up
2.74
120
4.25
1.65
16
1.39
Antiepileptics
in Serum
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
10 μl
Injection interval:
15 min
UV/VIS-Detector:
Lamotrig., Sulthiame: 265 nm
Other Antiepileptics: 205 nm
HPLC-Thermostat: 55 °C
➜ Simultaneous analysis of
13 antiepileptic drugs
ClinChek® Plasma Control, Level II, recorded at 265 nm:
8.00
Antiepileptic Drugs
Intensity (mV)
Antiepileptic drugs (AED) are the mainstay of epilepsy treatment. The medication enables the patient
to live free of epileptic seizures. Depending on the
type of epilepsy, several AEDs with diverse activity
mechanisms may be used for the management of
the disease. For the monitoring of the drug level, this
ClinRep® Complete Kit allows for the simultaneous
determination of 13* AEDs and metabolites.
93
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on:
ble so fully autoa
l
i
a
v
A
ra
uid
duct fo
liq
nal pro
n with
Additio
paratio
e
r
p
tes
la
le
well p
samp
s and
mated
m
e
t
s
ng sy
handli
0
-5
Test Data
The test data are available on request.
* In case samples do not contain carbamazepine and phenytoin,
the injection interval can be reduced to 9 min.
Sample Preparation
Precipitation:
100 μl sample
150 μl supernatant
4
6
8
10
12
14
TDM
3.25
1.48
1.69
7.45
1.85
0
2
4
6
8
10
12
14
Ethosuximide: 0.77 min, Primidone: 1.07 min, Sulthiame:
1.35 min, Lamotrigine: 1.65 min, 10-Hydroxy-Carbamazepine:
2.46 min, Phenobarbital: 2.94 min, Carbamazepine-epoxide:
4.11 min, Oxcarbazepine: 5.57 min, IS: 7.45 min,
Carbamazepine: 12.13 min, Phenytoin: 12.74 min
Lacosamide: 1.24 min, Zonisamide: 1.48 min, Felbamate:
1.69 min, Rufinamide: 1.85 min, N-Desmethylmethsuximide:
3.25 min, IS: 7.45 min
Ordering Information
Order No.
Description
Quantity
14000
ClinRep® Complete Kit, advanced, for Antiepileptics in Serum / Plasma for 100 assays
1 pce.
14010
14011
14012
14013
14020
14021
Kit Components (order no. 14000):
Mobile Phase
Standard Solution Antiepileptics 3
P Precipitant with Internal Standard
Serum Calibrator Antiepileptics 3, lyophil.
Sample Preparation Vials
D Diluting Solution
Manual
Quick Reference
1000 ml
3 ml
20 ml
3 ml
100 pcs.
25 ml
14111
15111
14113
15113
Optional Components:
Standard Solution Antiepileptics 4
Standard Solution for Lamotrigine and Sulthiame
Serum Calibrator Antiepileptics 4, lyophil.
Plasma Calibrator for Lamotrigine and Sulthiame, lyophil.
3
3
3
3
14030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
14080
14081
14082
14180
14181
14182
15180
15181
15182
ClinChek® Controls:
Serum Control Antiepileptics 3, lyophil., Level I
Serum Control Antiepileptics 3, lyophil., Level II
Serum Control Antiepileptics 3, lyophil., Level I, II
Serum Control Antiepileptics 4, lyophil., Level I
Serum Control Antiepileptics 4, lyophil., Level II
Serum Control Antiepileptics 4, lyophil., Level I, II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
➜
HPLC Analysis:
2
Retention Time (min)
centrifuge
250 μl Diluting Solution D
5
0
Retention Time (min)
200 μl Precipitant P
(contains Internal Standard)
➜
Dilution:
10
-5
0
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.8 ml/min
Injection volume:
10 μl
Injection interval:
15 min (9 min*)
UV-Detector:
205 nm
HPLC-Thermostat: 30 °C
15
1.24
Intensity (mV)
5
12.13
12.74
10
20
7.45
15
25
4.11
20
30
5.57
2.46
25
ClinChek® Serum Control, Level II (order no. 14181)
2.94
30
0.77
Antiepileptics
in Serum / Plasma,
advanced
ClinChek® Serum Control, Level II (order no. 14081)
1.35
1.07
1.65
Antiepileptic Drugs
Intensity (mV)
In addition to the reliable ClinRep® Complete Kit
with order no. 15000 (see pages 92 - 93), RECIPE
offers a new test kit with an advanced chromatography and an extended analyte spectrum. The kit
features simultaneous quantification of 16 different
antiepileptics and clinically relevant metabolites, including novel drugs such as rufinamide, lacosamide
and eslicarbazepine. By use of the same analytical
column the kit can easily be combined with the
ClinRep® Complete Kit for Levetiracetam (see pages
100 - 101).
ml
ml
ml
ml
Inject 10 μl of the diluted supernatant
➜ Advanced chromatography
with 16 AEDs
➜ Injection interval:
15 min (9 min)
➜ 1 analytical column
for 16 AEDs and
Levetiracetam
95
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soon: autoe
l
b
a
l
i
Ava duct for a fully uid
with liq
nal pro
aration
Additio
p
e
r
p
plates
sample
d well
n
a
s
mated
m
te
ng sys
handli
0.02
Test Data
The test data are available on request.
Precipitation:
100 μl sample
200 μl Precipitant P
(contains Internal Standard)
➜
Dilution:
150 μl supernatant
Inject 2 μl of the diluted supernatant
TDM
3.44
2.80
2.05
1.79
0.050
0.040
0.030
0.020
0.010
0.000
3.00
3.50 4.00
0.00 0.50 1.00 1.50 2.00 2.50
Retention Time (min)
Ethosuximide: 1.39 min, Primidone: 1.71 min, Sulthiame:
1.80 min, Lamotrigine: 1.92 min, 10-Hydroxy-Carbamazepine:
2.33 min, Phenobarbital: 2.65 min, Carbamazepine-epoxide:
2.92 min, Oxcarbazepine: 3.16 min, IS: 3.44 min,
Carbamazepine: 3.64 min, Phenytoin: 3.71 min
3.00
3.50 4.00
Retention Time (min)
Lacosamide: 1.79 min, Zonisamide: 1.86 min, Felbamate:
1.99 min, Rufinamide: 2.05 min, N-Desmethylmethsuximide:
2.80 min, IS: 3.44 min
Ordering Information
Order No.
Description
Quantity
14100
ClinRep® Complete Kit for Antiepileptics in Serum / Plasma for 100 assays
1 pce.
14108
14109
14011
14012
14013
14020
14021
250 μl Diluting Solution D
➜
UHPLC Analysis:
centrifuge
Intensity (AU)
3.44
3.64
3.71
3.16
0.04
0.060
2.92
0.06
1.92
0.08
2.65
0.070
1.39
0.10
1.86
1.99
0.090
0.080
2.33
0.12
0.00 0.50 1.00 1.50 2.00 2.50
Sample Preparation
➜ Simultaneous determination of 16 AEDs including:
– Lacosamide
– Zonisamide
– Felbamate
– Rufinamide
– Eslicarbazepine
0.100
0.00
UHPLC Parameters
Pump:
binary gradient pump,
flow rate: 0.4 ml/min
Injection volume:
2 μl
Injection interval:
5 min
UV-Detector:
205 nm
HPLC-Thermostat: 30 °C
ClinChek® Serum Control, Level II (order no. 14181)
0.14
1.71
Antiepileptics
in Serum / Plasma
with UHPLC
ClinChek® Serum Control, Level II (order no. 14081)
1.80
Antiepileptic Drugs
Intensity (AU)
This new ClinRep® UHPLC Complete Kit shows an
identical analyte spectrum as the ClinRep® HPLC
Complete Kit with order no. 14000 (see pages 94 95). Thus, the following 16 substances can be
quantified simultaneously: carbamazepine, eslicarbazepine, ethosuximide, felbamate, lacosamide,
lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, rufinamide, sulthiame and zonisamide as well as the pharmacologically active metabolites N-desmethylmethsuximide, 10-hydroxy-carbamazepine and carbamazepine-epoxide. The chromatographic separation is performed with an injection interval of 5 min only.
Kit Components (order no. 14100):
Mobile Phase A
Mobile Phase B
Standard Solution Antiepileptics 3
P Precipitant with Internal Standard
Serum Calibrator Antiepileptics 3, lyophil.
Sample Preparation Vials
D Diluting Solution
Manual
Quick Reference
400 ml
200 ml
3 ml
20 ml
3 ml
100 pcs.
25 ml
14111
15111
14113
15113
Optional Components:
Standard Solution Antiepileptics 4
Standard Solution for Lamotrigine and Sulthiame
Serum Calibrator Antiepileptics 4, lyophil.
Plasma Calibrator for Lamotrigine and Sulthiame, lyophil.
3
3
3
3
14130
Start Accessories:
Analytical Column with test chromatogram
1 pce.
14080
14081
14082
14180
14181
14182
15180
15181
15182
ClinChek® Controls:
Serum Control Antiepileptics 3, lyophil., Level I
Serum Control Antiepileptics 3, lyophil., Level II
Serum Control Antiepileptics 3, lyophil., Level I, II
Serum Control Antiepileptics 4, lyophil., Level I
Serum Control Antiepileptics 4, lyophil., Level II
Serum Control Antiepileptics 4, lyophil., Level I, II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level II
Plasma Control for Lamotrigine and Sulthiame, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
ml
ml
ml
ml
➜ Injection interval: 5 min
97
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ClinChek® Plasma Control, Level I:
Test Data
Linearity:
0.5 - 50 μg/ml
Recovery:
95 - 105 %
LLOD:
0.2 μg/ml
LLOQ:
0.5 μg/ml
Intraassay precision: 2.4 %
Interassay precision: 2.6 %
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
20 μl
Injection interval:
7 min*
UV/VIS-Detector:
265 nm
HPLC-Thermostat: 55 °C
4.64
4.64
20
15
10
Intensity (mV)
1.74
15
2.44
Lamotrigine and
Sulthiame in Plasma
20
1.75
25
25
TDM
ClinChek® Plasma Control, Level II:
2.45
Antiepileptic Drugs
Intensity (mV)
Lamotrigine and sulthiame are important antiepileptic
drugs (AED) in the management of several types
of epilepsy. This ClinRep® Complete Kit is especially
designed for the determination of lamotrigine and
sulthiame from plasma. It features a short time for
analysis (7 min) and excellent test precision.
5
0
0
1
2
3
4
5
6
10
5
0
0
Retention Time (min)
Sulthiame: 1.74 min, Lamotrigine: 2.44 min, IS: 4.64 min
1
2
3
4
5
6
Retention Time (min)
Sulthiame: 1.75 min, Lamotrigine: 2.45 min, IS: 4.64 min
Ordering Information
Order No.
Description
Quantity
15100
ClinRep® Complete Kit for Lamotrigine, Sulthiame in Plasma for 100 assays
1 pce.
Kit Components (order no. 15100):
Mobile Phase
Standard Solution
P Precipitant with Internal Standard
Plasma Calibrator, lyophil.
Sample Preparation Vials with Reagent, lyophil.
D Diluting Solution
Manual
Quick Reference
1000 ml
3 ml
15 ml
3 ml
2 x 15020 (2 x 50 pcs.)
10 ml
1 pce.
1 pce.
15030
15032
Start Accessories:
Analytical Column with test chromatogram
Guard Column Holder incl. 1 Guard Column
1 pce.
1 pce.
15031
Refill Service:
Analytical Column with test chromatogram (original column needs to be returned)
1 pce.
15033
FK5810
FK5820
FK5821
Accessories:
Guard Column
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
5 pcs.
1 pce.
1 pce.
10 pcs.
15180
15181
15182
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
15010
15111
15112
15113
15020
15021
* In case the sample contains carbamazepine, the run
time must be extended to 15 min.
Sample Preparation
Extraction:
100 μl plasma
150 μl Precipitant P
(contains Internal Standard IS)
➜
Dilution:
100 μl supernatant
➜ Injection interval: 7 min
100 μl Diluting Solution D
➜
HPLC Analysis:
centrifuge
Inject 20 μl of the diluted supernatant
➜ Excellent test precision
99
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Test Data
12
10
Intensity (mV)
10
8
6
4
2
TDM
14
12
4.93
14
2.57
ClinChek® Serum Control, Level II
4.93
Levetiracetam (Keppra®)
in Serum and Plasma –
Manual Sample Prep. /
with Gilson® ASPEC™
ClinChek® Serum Control, Level I
2.58
Antiepileptic Drugs
Intensity (mV)
The RECIPE analytical method for levetiracetam
completes the RECIPE kit portfolio for the analysis
of antiepileptic drugs (AED). The sample preparation can be performed either manually (complete kit
with order no. 15500) or automated with the Gilson®
ASPEC™ pipetting system (order no. 15600). By
the use of the same analytical column, the kits can
easily be combined with the AED test kit with order
no. 14000 (see pages 94 - 95) which allows the
quantification of further 16 different drugs and clinically relevant metabolites.
8
6
4
2
0
0
0
1
2
3
4
5
6
0
1
2
3
4
Retention Time (min)
Retention Time (min)
Levetiracetam: 2.58 min, IS: 4.93 min
Levetiracetam: 2.57 min, IS: 4.93 min
5
6
Manual / Automated Processing (Gilson® ASPEC™)
Linearity:
Recovery:
LLOD:
LLOQ:
Intraassay precision:
Interassay precision:
0.5 - 1000 / 0.5 - 200 mg/l
97 - 105 / 90 - 102 %
0.15 mg/l
0.5 mg/l
1.5 / 1.2 %
1.9 / 1.9 %
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.4 ml/min
20 μl
6 min
205 nm
30 °C
Injection volume:
Injection interval:
UV-Detector:
HPLC-Thermostat:
Sample Preparation
Manual / Automated Processing (Gilson® ASPEC™)
Ordering Information
Order No.
Description
Quantity
15500
15600
ClinRep® Complete Kit for Levetiracetam in Serum / Plasma
– manual sample preparation, for 100 assays
– with Gilson® ASPEC™, for 200 assays
1 pce.
1 pce.
Kit Components :
– order no. 15500
Mobile Phase
Sample Preparation Columns
W Washing Solution 1
– order no. 15600
Mobile Phase
Sample Preparation Columns
W Washing Solution 1
– order nos. 15500 / 15600
Standard Solution
IS Internal Standard
Serum Calibrator, lyophil.
Conditioning Reagent
W Washing Solution 2
E Eluting Reagent
User Manual
Quick Reference
3 ml
10 ml
3 ml
300 ml
100 ml
100 ml
1 pce.
1 pce.
14030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
15580
15581
15582
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
15510
15520
15522
15510
15620
15522
15511
15512
15513
15521
15523
15524
Extraction:
Apply (conditioned* sample preparation column):
Sample
(100 μl / 50 μl)
Internal Standard IS
(100 μl / 50 μl)
➜
wash with
➜ 1 analytical column for
levetiracetam and further
16 AEDs
Elution:
Apply Eluting Reagent E
(1 ml / 500 μl)
➜
HPLC Analysis:
➜ Optional: method
with automated
sample preparation
1. Washing Solution W1
(3 ml / 1 ml)
2. Washing Solution W2
(1 ml / 330 μl)
1000 ml
2 x 15520 (2 x 50 pcs.)
3 x 15522 (3 x 200 ml)
2 x 15510 (2 x 1000 ml)
2 x 15620 (2 x 100 pcs.)
2 x 15522 (2 x 200 ml)
Inject 20 μl
* Conditioning with Conditioning Reagent
and Washing Solution W1
101
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ClinChek® Plasma Control, Level I:
70
60
60
50
50
20
Test Data
Linearity:
0.1 - 40 mg/l
Recovery:
95 - 105 %
LLOD:
0.06 mg/l
LLOQ:
0.1 mg/l
Intraassay precision: 3.3 %
Interassay precision: 4.0 %
20
5
6
10
4.99
10
40
30
6.05
30
4.99
40
TDM
70
Intensity (mV)
Mycophenolic Acid
in Plasma
ClinChek® Plasma Control, Level II:
6.05
Immunosuppressants
Intensity (mV)
Mycophenolate mofetil (MMF) belongs to the newer
immunosuppressive drugs and is usually used in
combination with cyclosporine A or tacrolimus. As a
pro-drug, MMF is rapidly hydrolised in vivo to its
active constituent mycophenolic acid (MPA). In order
to reach an optimal therapeutic efficiency, i.e. to
maximise drug efficiency while minimising its toxicity, the administration of MMF requires monitoring
of the MPA concentration with subsequent dosage
adjustment. For this purpose, our ClinRep® HPLC
Complete Kit provides an easy and quick sample
preparation and enables a reliable and fast analysis.
0
0
0
1
2
3
4
5
6
0
7
Retention Time (min)
1
2
3
4
7
Retention Time (min)
Mycophenolic acid: 4.99 min, IS: 6.05 min
Mycophenolic acid: 4.99 min, IS: 6.05 min
Ordering Information
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.2 ml/min
Injection volume:
50 μl
Injection interval:
7 min
UV/VIS-Detector:
215 nm
HPLC-Thermostat: 30 °C
Order No.
Description
Quantity
29000
ClinRep® Complete Kit for Mycophenolic Acid in Plasma for 100 assays
1 pce.
Kit Components (order no. 29000):
Mobile Phase
Test Solution
IS Internal Standard
Plasma Calibrator, lyophil.
Sample Preparation Vials
P Precipitant
Manual
Quick Reference
1000 ml
3 ml
2 ml
3 ml
100 pcs.
20 ml
1 pce.
1 pce.
29030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
29080
29081
29082
29083
ClinChek® Controls:
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
10 x 3 ml
10 x 3 ml
10 x 3 ml
3 x 3 x 3 ml
29010
29014
29012
29013
29020
29021
Sample Preparation
Precipitation:
100 μl plasma
➜
HPLC Analysis:
20 μl Internal
Standard IS
centrifuge
200 μl
Precipitant P
Inject 50 μl of the supernatant
Level
Level
Level
Level
I
II
III
I, II, III
➜ Easy and quick
sample preparation
➜ Reliable chromatography
➜ Injection interval: 7 min
103
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 104
➜ On-line sample
preparation
4
2
8
Injection volume:
Injection interval:
UV-detector:
HPLC-thermostat:
Olz, D-Olz, Clz, D-Clz, Qtp
Plp, Rsp
flow rates: 0.5 / 1.0 ml/min
flow rate: A: 1.3 ml/min
B: 1.0 ml/min
6-port/3-channel
(order no. FK1102)
A: 250 μl, B: 750 μl
A: 22 min, B: 20 min
A: 254 nm, B: 280 nm
30 °C
Addition of IS:
A: Add 20 μl Internal Standard IS/ml sample
B: Add 10 μl Internal Standard IS/ml sample
➜
On-Line Analysis:
TDM
16.65
2
0
9 10 11 12 13 14 15 16 17 18 19 20 21 22
9
Olz / D-Olz:
5 / 10 - 1000 μg/l
Clz / D-Clz:
6 / 5 - 5000 μg/l
Qtp: 10 - 2000 μg/l
Plp, Rsp: 1 - 200 μg/l
Recovery:
100 %
LLOD:
2 μg/l (Olz, Clz, D-Clz),
4 μg/l (D-Olz, Qtp)
0.4 μg/l (Plp, Rsp)
LLOQ:
5 μg/l (Olz), 6 μg/l (Clz),
10 μg/l (D-Olz, Qtp),
4 μg/l (D-Clz)
1 μg/l (Plp, Rsp)
Intraassay precision: 0.2 - 2 %
Interassay precision: 1 - 6 %
Switching valve:
4
11.68
Intensity (mV)
6
20.25
14.43
8
10.47
6
18.55
12.27
10
Test Data
Linearity:
Sample Pretreatment
➜ 100 % recovery
12
0
HPLC Parameters
A: Determination of
B: Determination of
Isocratic pump 1
(SPE buffer):
Isocratic pump 2
(mobile phase):
➜ Fully automated method
Chromatogram of the plasma calibrator, order no. 40113
(+ 10 μl Internal Standard IS per ml sample, order no. 40012)
8
11.15
Atypical Neuroleptics
in Plasma / Serum –
On-Line Analysis
Chromatogram of the plasma calibrator, order no. 40013
(+ 20 μl Internal Standard IS per ml sample, order no. 40012)
9.51
Psychoactive Drugs
Intensity (mV)
The drugs olanzapine, clozapine, quetiapine, risperidone, and paliperidone (= 9-OH-risperidone)
belong to the class of the so called ”atypical” neuroleptics and are used for the treatment of schizophrenia. Co-medication, smoking, caffeine and food
are factors that extensively influence their metabolism and thus lead to a high intra- and interindividual
variability of drug concentrations in blood. In order to
avoid severe side effects by overdosing and to ensure an optimal therapeutic effect, therapeutic drug
monitoring (TDM) is required. The RECIPE Complete
Kit represents a fully automated, robust on-line
technique, that allows for a direct sample injection
into the HPLC system.
10
11
12
13
14
15
16
17
18
19
20
Retention Time (min)
Retention Time (min)
Desmethylolanzapine (D-Olz): 9.51 min, Olanzapine (Olz):
11.15 min, Desmethylclozapine (D-Clz): 12.27 min, Internal
Standard IS: 14.43 min, Clozapine (Clz): 18.55 min,
Quetiapine (Qtp): 20.25 min
Paliperidone (Plp): 10.47 min, Risperidone (Rsp): 11.68 min,
Internal Standard IS: 16.65 min
Ordering Information
Order No.
Description
Quantity
40000
ClinRep® Complete Kit for Atypical Neuroleptics in Plasma / Serum
for 100 assays
1 pce.
Kit Components (order no. 40000):
SPE-Buffer
Mobile Phase
Plasma Calibrator, lyophil.
Manual
Quick Reference
2
2
5
1
1
40012
40014
40113
40114
Optional Components:
IS Internal Standard
Test Solution, lyophil.
Plasma Calibrator, lyophil., for Risperidone and Paliperidone
Test Solution, for Risperidone and Paliperidone
2 ml
5 x 2 ml
5 x 5 ml
15 ml
40030
40031
40032
40033
FK7400
Start Accessories:
Analytical Column with test chromatogram
SPE-Column
Guard Column Holder incl. 1 Guard Column
Guard Column
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
5
1
40034
Refill Service:
SPE-Column, refill (original column needs to be returned)
1 pce.
FK1102
FK7330
FK7340
FK7350
Accessories:
Switching valve, Sykam (6-port/3-channel) incl. electr. drive, PEEK
Endfittings
Sealings and sieves
Endstoppers
1
2
4
2
40080
40081
40082
40180
40181
40182
ClinChek® Controls:
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
Plasma Control, lyophil.,
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
10 x 5 ml
10 x 5 ml
2 x 5 x 5 ml
40009
40010
40013
Level I
Level II
Level I, II
for Risperidone and Paliperidone, Level I
for Risperidone and Paliperidone, Level II
for Risperidone and Paliperidone, Level I, II
x 40009 (2 x 1000 ml)
x 40010 (2 x 2000 ml)
x 3 ml
pce.
pce.
pce.
pce.
pce.
pcs.
pce.
pce.
pcs.
pcs. each
pcs.
centrifuge
A: Inject 250 μl
B: Inject 750 μl
105
HBM
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HPLC Complete Kits
ClinTox® HBM
for Human Biomonitoring
Benzene and Derivatives
ortho-Cresol and Phenol in Urine . . . 108 - 109
Hippuric Acid and
Methylhippuric Acids in Urine . . . . . . 110 - 111
t,t-Muconic Acid in Urine . . . . . . . . . . 112 - 113
Polycyclic Aromatic Hydrocarbons (PAH)
1-Hydroxypyrene in Urine –
On-Line Analysis . . . . . . . . . . . . . . . . . 114 - 115
107
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Test Data
Linearity:
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
10 - 20 μl
Injection interval:
15 min
Fluorescence
detector:
277 nm (exc.), 300 nm (em.)
HPLC-Thermostat: 30 °C
Sample Preparation
Enzymatic treatment:
250 μl urine
50 μl Internal
Standard IS
50 μl
Reagent D
incubate (37 °C, 2 - 24 h)
Transfer the whole sample to a conditioned
sample preparation column
Elution:
➜
➜ Enzymatic release
of the analytes
250 μl
Reagent C
➜
Extraction:
2
4
6
8
10
12
14
9.87
HBM
12.39
12.39
0
-149
500
11.07
Intensity (mV)
500
5.62
1000
9.87
1000
0
o-Cresol: 0.05 - 50 mg/l,
Phenol: 0.2 - 50 mg/l
Recovery:
85 - 95 %
LLOD:
o-Cresol: 0.03 mg/l,
Phenol: 0.1 mg/l
LLOQ:
o-Cresol: 0.05 mg/l,
Phenol: 0.2 mg/l
Intraassay precision: o-Cresol: 2.4 %,
Phenol: 3.2 %
Interassay precision: o-Cresol: 2.8 %,
Phenol: 4.8 %
ClinChek® Urine Control, Level II:
11.06
ortho-Cresol and
Phenol in Urine
ClinChek® Urine Control, Level I:
5.62
Benzene and Derivatives
Intensity (mV)
o-Cresol is a minor metabolite of toluene and serves for the assessment of an exposure to toluene,
which is a frequently used solvent in glues, paints
and thinners. In contrast to hippuric acid (see pages
110 - 111), which is the main metabolite of toluene,
o-cresol is not a physiological component of urine
and therefore reflects the internal exposure towards
the pollutant. Phenol is the main metabolite of benzene and is used for the assessment of benzene
as well as of phenol itself. The RECIPE ClinTox®
Complete Kit provides an excellent analytical sensitivity and ensures a reliable biomonitoring of both
analytes. The sample clean up is performed via
solid phase extraction (SPE).
0
-149
0
2
4
6
8
10
12
14
Retention Time (min)
Retention Time (min)
Phenol: 5.62 min, p-Cresol: 9.87 min, o-Cresol: 11.06 min,
IS: 12.39 min
Phenol: 5.62 min, p-Cresol: 9.87 min, o-Cresol: 11.07 min,
IS: 12.39 min
Ordering Information
Order No.
Description
Quantity
53000
ClinTox® Complete Kit for o-Cresol and Phenol in Urine for 100 assays
1 pce.
Kit Components (order no. 53000):
Mobile Phase
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
Reagent A
Reagent B
Reagent C
Reagent D
Manual
Quick Reference
1000 ml
5 ml
5 x 5 ml
2 x 52320 (2 x 50 pcs.)
400 ml
2 x 53022 (2 x 300 ml)
25 ml
3 x 53024 (3 x 2 ml)
1 pce.
1 pce.
52330
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK3000
FK5810
FK5820
FK5821
FK6200
FK6220
FK6230
Accessories:
Thermocult Incubator (37 °C)
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
Sample vial with screw thread, clear glass, 1.5 ml
Screw cap with hole for order no. FK6200
PTFE-septum for order no. FK6220
1 pce.
1 pce.
1 pce.
10 pcs.
100 pcs.
100 pcs.
100 pcs.
8925
ClinChek® Controls:
Urine Control, lyophil., Level I, II
2 x 5 x 5 ml
53010
53012
9925
52320
53021
53022
53023
53024
wash (2 x 2 ml Reagent B)
Elute with 2 ml Reagent A
HPLC Analysis:
➜
➜ Sample clean-up via SPE
collect the eluate
Inject 10 - 20 μl
➜ Injection interval: 15 min
➜ High analytical sensitivity
109
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ClinChek® Urine Control, Level I:
120
120
100
100
4.23
6.43
40
HPLC Parameters
Pump:
isocratic pump,
flow rate: 1.0 ml/min
Injection volume:
20 μl
Injection interval:
8 min
UV-Detector:
230 nm
HPLC-Thermostat: 30 °C
Sample Preparation
40
0
0
Hippuric Acid:
50 - 10000 mg/l,
Methylhippuric Acids:
5 - 5000 mg/l
Recovery:
85 - 95 %
LLOD:
Hippuric Acid: 30 mg/l,
Methylhip. Acids: 2 mg/l
LLOQ:
Hippuric Acid: 50 mg/l,
Methylhip. Acids: 4 mg/l
Intraassay precision: Hippuric Acid: 2.0 %,
Methylhip. Acids: 2.1 %
Interassay precision: Hippuric Acid: 2.3 %,
Methylhip. Acids: 3.2 %
60
20
0
Test Data
Linearity:
80
HBM
60
6.52
5.07
80
5.14
Intensity (mV)
140
20
3.24
160
140
4.29
160
Hippuric Acid and
Methylhippuric Acids
in Urine
ClinChek® Urine Control, Level II:
3.19
Benzene and Derivatives
Intensity (mV)
This ClinTox® Complete Kit is designed for the
reliable biomonitoring of hippuric acid and of o-, mand p-methylhippuric acid. Those compounds are
the urinary metabolites of toluene and of the corresponding xylenes and thus reflect an exposure
level towards these pollutants. Sample preparation
columns and analytical column of this kit can also
be used for the determination of o-cresol and phenol
in urine (see pages 108 - 109).
1
2
3
4
5
6
7
8
0
Retention Time (min)
Hippuric acid: 3.19 min, o-Methylhippuric acid: 4.23 min,
IS: 5.07 min, m-/p-Methylhippuric acid: 6.43 min
1
2
3
4
5
6
7
8
Retention Time (min)
Hippuric acid: 3.24 min, o-Methylhippuric acid: 4.29 min,
IS: 5.14 min, m-/p-Methylhippuric acid: 6.52 min
Ordering Information
Order No.
Description
Quantity
52000
ClinTox® Complete Kit for Hippuric Acid and Methylhippuric Acids in Urine
for 100 assays
1 pce.
Kit Components (order no. 52000):
Mobile Phase
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
Reagent A
Reagent B
Manual
Quick Reference
1000 ml
3 ml
10 ml
5 x 5 ml
2 x 52320 (2 x 50 pcs.)
400 ml
2 x 52022 (2 x 400 ml)
1 pce.
1 pce.
52330
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
8922
ClinChek® Controls:
Urine Control, lyophil., Level I, II
2 x 5 x 5 ml
52010
52011
52012
9922
52320
52021
52022
Dilution:
Extraction:
100 μl Internal
Standard IS
2 ml Reagent B
➜
➜ Sample clean-up via SPE
100 μl urine
Transfer the whole sample to a conditioned
sample preparation column
Elution:
➜
➜ Injection interval: 8 min
wash (2 x 2 ml Reagent B)
Elute with 2 ml Reagent A
HPLC Analysis:
➜
➜ High analytical sensitivity
collect the eluate
Inject 20 μl
111
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ClinChek® Urine Control, Level II:
100
HBM
7.15
Intensity (mV)
7.15
6
8
0
2
4
6
8
Retention Time (min)
t,t-Muconic acid: 5.75 min, IS: 7.15 min
Ordering Information
➜
➜
Order No.
Description
Quantity
51000
ClinTox® Complete Kit for t,t-Muconic Acid in Urine for 100 assays
1 pce.
Kit Components (order no. 51000):
Mobile Phase A
Mobile Phase B
Standard Solution
IS Internal Standard
Urine Calibrator, lyophil.
Sample Preparation Columns
Reagent A
Reagent B
Reagent C
Reagent D
Manual
Quick Reference
2 x 51008 (2 x 1000 ml)
800 ml
3 ml
15 ml
5 x 5 ml
2 x 51020 (2 x 50 pcs.)
300 ml
400 ml
300 ml
300 ml
1 pce.
1 pce.
51030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK5810
FK5820
FK5821
Accessories:
PEEK tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
1 pce.
10 pcs.
8922
ClinChek® Controls:
Urine Control, lyophil., Level I, II
2 x 5 x 5 ml
51008
51009
51011
51012
9922
51020
51021
51022
51023
51024
1 ml Reagent B
wash (2 x 1.5 ml Reagent C)
Elute with 2 x 1.5 ml Reagent D
➜
HPLC Analysis:
4
t,t-Muconic acid: 5.83 min, IS: 7.15 min
Transfer the whole sample to a conditioned
sample preparation column
Elution:
2
Retention Time (min)
Dilution:
Extraction:
50
0
-11
0
Sample Preparation
150 μl Internal
Standard IS
50
0
-11
Test Data
Linearity:
0.24 - 20 mg/l
Recovery:
75 - 80 %
LLOD:
0.07 mg/l
LLOQ:
0.24 mg/l
Intraassay precision: 5.9 %
Interassay precision: 5.5 %
1 ml urine
100
5.83
t,t-Muconic Acid
in Urine
HPLC Parameters
Pump:
gradient pump,
flow rate: 1.0 ml/min
Injection volume:
50 μl
Injection interval:
18 min
UV-Detector:
264 nm
HPLC-Thermostat: 45 °C
➜ High diagnostic specificity
ClinChek® Urine Control, Level I:
5.75
Benzene and Derivatives
Intensity (mV)
t,t-Muconic acid is a minor metabolite of benzene
and serves for the assessment of an occupational
benzene exposure. In contrast to phenol (see pages
108 - 109), t,t-muconic acid is not a physiological
component of urine and thus provides a higher
diagnostic specificity. This ClinTox® Complete Kit
represents a robust and sensitive method with a
highly selective sample preparation, followed by
isocratic separation with UV detection.
collect the eluates
Inject 50 μl
➜ Highly selective sample
preparation
➜ High analytical sensitivity
113
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5
5
4
4
3
3
1
0
Sample Pretreatment
Enzymatic hydrolysis:
2 ml urine
1 ml Stabilising
Reagent S
➜
1. incubate (37 °C, 2 - 36 h)
10 μl Enzyme
Solution
2. centrifuge
12
14
16
18
20
22
24
0
10
Retention Time (min)
1-Hydroxypyrene: 18.17 min
12
14
16
18
20
22
24
Retention Time (min)
1-Hydroxypyrene: 18.00 min
Ordering Information
Order No.
Description
Quantity
50000
ClinTox® Complete Kit for 1-Hydroxypyrene in Urine for 100 assays
1 pce.
Kit Components (order no. 50000):
Mobile Phase A
Mobile Phase B
SPE - Buffer
Urine Calibrator, lyophil.
S Stabilising Reagent
Enzyme Solution
Manual
Quick Reference
1500 ml
2 x 50008 (2 x 2000 ml)
2 x 50009 (2 x 2500 ml)
5 x 5 ml
200 ml
1 ml
1 pce.
1 pce.
50030
FK7000
50031
50032
Start Accessories:
Analytical Column with test chromatogram
manu-CART® cartridge holder, one time accessory
SPE - Column
Guard Column
1
1
1
5
50040
FK5405
FK5810
FK5820
FK5821
FK1103
FK3000
Accessories:
Vials for Sample Pretreatment with Screw Cap, 10 ml
Sample loop, stainless steel, 500 μl
PEEK-tubing (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
Switching valve, Sykam (6-port/3-channel) incl. electr. drive, steel
Thermocult Incubator (37 °C)
100 pcs.
1 pce.
1 pce.
1 pce.
10 pcs.
1 pce.
1 pce.
8925
ClinChek® Controls:
Urine Control, lyophil., Level I, II
2 x 5 x 5 ml
50007
50008
50009
9925
50021
50022
On-Line Analysis:
Inject 250 μl
1
1
10
Test Data
Linearity:
100 - 24000 ng/l
Recovery:
100 %
LLOD:
20 ng/l
LLOQ:
100 ng/l
Intraassay precision: 2.6 %
Interassay precision: 2.9 %
2
HBM
2
1
HPLC Parameters
Pump 1:
gradient pump,
flow rates: 1.0, 1.5 ml/min
Pump 2:
isocratic pump: 1.0 ml/min
Switching valve:
6-port/3-channel
(order no. FK1103)
Injection volume:
250 μl
Injection interval:
36 min
Fluorescence
detector:
242 nm (exc.), 388 nm (em.)
HPLC-Thermostat: 30 °C
➜ Fully automated method
ClinChek® Urine Control, Level II:
18.00
1-Hydroxypyrene
in Urine –
On-Line Analysis
ClinChek® Urine Control, Level I:
Intensity (mV)
Polycyclic Aromatic Hydrocarbons
18.17
PAH
Intensity (mV)
Urinary 1-hydroxypyrene is used as a biological
index for the assessment of an exposure to polycyclic aromatic hydrocarbons (PAH). Many individual PAHs are genotoxic carcinogens and are formed by the incomplete combustion of fossil fuels.
The RECIPE ClinTox® Complete Kit is designed for
the automated determination of urinary 1-hydroxypyrene in order to estimate an environmental or
occupational related PAH exposure. The sample preparation is performed on-line by column switching
using a highly selective SPE-column (SPE: solid
phase extraction).
pce.
set
pce.
pcs.
➜ Recovery 100 %
➜ High analytical sensitivity
115
LC-MS/MS
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 116
LC-MS/MS
ClinMass® Complete Kits
ClinMass® Optimisation
Mixes and Internal Standards
ClinMass® LC-MS/MS Complete Kits are designed
for a reliable and standardised analysis with tandem
mass spectrometry. Similar to our HPLC complete
kits, all components required for analysis are included (with the exception of start accessories, optimisation mixes, accessories, and matrix controls).
ClinMass® Optimisation Mixes are applied to optimise the MS/MS parameters, as well as for the
subsequent check-up of the analytical system.
ClinMass® Internal Standards are used for the internal standardisation of the LC-MS/MS analysis.
These components are available for various parameters also as kit-independent ivd-reagents and
can be used for the verification or implementation
of inhouse methods.
117
Complete Kits
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 118
LC-MS/MS
ClinMass® Complete Kits
Alcoholism
Ethylglucuronide and Ethylsulfate
in Urine, Plasma and Serum . . . . . . . 120 - 121
Immunosuppressants
Immunosuppressants in
Whole Blood – On-Line Analysis . . . 122 - 123
Immunosuppressants in
Whole Blood, advanced
– On-Line Analysis . . . . . . . . . . . . . . . 124 - 125
Metabolic Disease
Homocysteine in Plasma / Serum . . 126 - 127
Homocysteine in
Whole Blood (DBS) . . . . . . . . . . . . . . 128 - 129
Psychoactive Drugs
Benzodiazepines in Serum
– On-Line Analysis . . . . . . . . . . . . . . . 130 - 131
Vitamin Status
Methylmalonic Acid
in Serum / Plasma / Urine,
advanced . . . . . . . . . . . . . . . . . . . . . . . 132 - 133
25-OH Vitamin D2 / D3 in Plasma
and Serum – On-Line Analysis . . . . . 134 - 135
119
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Test Data (Urine)
Linearity:
EtG: 76.2 - 100000 μg/l
EtS: 21.8 - 76356 μg/l
LLOD:
EtG: 45.7 μg/l / EtS: 13.1 μg/l
LLOQ:
EtG: 76.2 μg/l / EtS: 21.8 μg/l
Intraassay precision: EtG: 5.3 % / EtS: 4.6 %
Interassay precision: EtG: 5.4 % / EtS: 4.9 %
LC-MS/MS Parameters
LC-Parameters
HPLC pump:
isocratic, flow rates:
0.2 ml/min, 0.5 ml/min
Injection volume:
10 μl
Injection interval:
5 min
Column heater:
40 °C
MS-Parameters
Ion source:
ESI negative
MS/MS-Mode:
MRM
3300
3200
3000
2800
2600
2400
2200
2000
1800
1600
1400
1200
1000
800
600
400
200
0.0
1.9
Dilution:
50 μl urine
(calibrator, control, patient)
➜ First CE/IVD test kit
for LC-MS/MS
Dilution:
mix, centrifuge
50 μl
supernatant
LC-MS/MS Analysis:
500 μl
Diluting Solution D
3.8
97.8
96.8
4.5
Retention Time (min)
Quantity
MS8000
ClinMass® Complete Kit for Ethylglucuronide and Ethylsulfate in Urine
for 400 assays
1 pce.
MS8005
MS8010
MS8012
MS8713
MS8100
Kit Components (order no. MS8000):
Autosampler Washing Solution
Mobile Phase
IS Internal Standard
Urine Calibrator Set, lyophil., Level 0 - 6
Manual
ClinMass® Supplement Kit for Ethylglucuronide and Ethylsulfate in Plasma and Serum
for 100 assays
1000 ml
1000 ml
4 x MS8012 (4 x 100 ml)
7 x 1 x 1 ml
1 pce.
1 pce.
MS8112
MS8113
MS8121
Kit Components (order no. MS8100):
IS Internal Standard
Serum Calibrator Set, lyophil., Level 0 - 3
D Diluting Solution
30 ml
4 x 1 x 1 ml
50 ml
MS8014
MS8413
Additional Components:
Optimisation Mix
Urine Calibrator Set, lyophil., Level 0 - 3
2 ml
4 x 1 x 1 ml
MS8030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
MS8080
MS8081
MS8082
MS8083
MS8180
MS8181
MS8182
ClinChek® Controls:
Urine Control, lyophil., Level I
Urine Control, lyophil., Level II
Urine Control, lyophil., Level III
Urine Control, lyophil., Level I, II, III
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 1 ml
10 x 1 ml
10 x 1 ml
3 x 3 x 1 ml
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
➜
➜ Method validation
according to
GTFCh guidelines
➜
➜ Fast and easy
sample preparation
300 μl
Internal Standard IS
2.4
4.10 EtS
m/z: 124.8
Description
B: Plasma / Serum
100 μl sample
(calibrator, control, patient)
74.8
4.05 d5-EtS
m/z: 129.9
Order No.
Inject 10 μl
Precipitation:
2.14 EtG
m/z: 220.9
1.6e5
1.5e5
1.4e5
1.3e5
1.2e5
1.1e5
1.0e5
9.0e4
8.0e4
7.0e4
6.0e4
5.0e4
4.0e4
3.0e4
2.0e4
1.0e4
0.0
Ordering Information
1000 μl
Internal Standard IS
➜
LC-MS/MS Analysis:
74.8
Retention Time (min)
Sample Preparation
A: Urine
2.11 d5-EtG
m/z: 226.1
Complete Kits
Ethylglucuronide and
Ethylsulfate in Urine,
Plasma and Serum
Intensity (cps)
Chromatogram of the ClinChek® Urine Control, Level II (order no. MS8081):
Alcoholism
Intensity (cps)
Ethylglucuronide (EtG) and ethylsulfate (EtS) are
known as relatively new, specific parameters for the
assessment of alcohol consumption, which dates
back several days. The analysis is primarily performed from urine but may be extended to plasma and
serum. For this purpose RECIPE offers a ClinMass®
Complete Kit for analysis from urine, which can be
expanded to plasma and serum samples (ClinMass®
Supplement Kit, order no. MS8100). The analytical
method features fast and easy sample preparation
and guarantees a reliable analyte determination.
The kit validation was established in compliance
with the German GTFCh guidelines for quality
assurance.
Inject 10 μl
121
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This ClinMass® Complete Kit is designed for the the-
Immunosuppressants
Chromatogram (left) and mass traces (right) of the ClinCal® Whole Blood Calibrator for Immunosuppressants, Level 4, order no. 9933
tacrolimus, sirolimus and everolimus. The sample pre-
val. A 4-Level and a 7-Level ClinCal® Whole Blood
Calibrator Set are provided for precise calibration and
measurement. The calibration range may be optionally
Immunosuppressants
in Whole Blood –
On-Line Analysis
extended by use of an additional high calibration point.
:
e soonlly autol
b
a
l
i
a
fu
Av
ct for a
id
u
du
with liq
nal pro
aration
Additio
p
e
r
e
p
t
pla s
sample
nd well
a
s
mated
m
e
t
ng sys
handli
Test Data
Linearity (up to):
2000 μg/l (Cyc), 80 μg/l (Tcr, Srl, Evr)
LLOD:
0.011 μg/l (Cyc), 0.004 μg/l (Tcr),
0.073 μg/l (Srl), 0.126 μg/l (Evr)
LLOQ:
0.037 μg/l (Cyc), 0.014 μg/l (Tcr),
0.244 μg/l (Srl), 0.420 μg/l (Evr)
Intraassay precision:
2.3 % (Cyc), 4.8 % (Tcr), 4.8 % (Srl), 5.0 % (Evr)
Interassay precision:
7.7 % (Cyc), 3.6 % (Tcr), 4.4 % (Srl), 4.1 % (Evr)
LC-MS/MS Parameters
LC-Parameters
Pump 1: SPE-Buffer (0.1 / 2.5 ml/min)
Pump 2: Mobile Phase (0.5 / 1.0 ml/min)
Injection volume:
50 μl
Injection interval:
2 min
Switching valve:
6-port/3-channel
(order no. FK1102)
Column heater:
60 °C
MS-Parameters
Ion source:
ESI positive
MS/MS-Mode:
MRM
➜ 4- and 7-Level calibrator
set available
Sample Pretreatment
Precipitation:
200 μl
Precipitant P
20 μl Internal
Standard IS
➜
➜ Calibration range
optionally extensible
On-Line Analysis:
100 μl whole blood
(calibrator, control,
patient)
1. mix and incubate
(ambient temperature)
2. mix and centrifuge
Inject 50 μl of the supernatant
➜ Controls available
in five levels
1.7e4
1.6e4
1.5e4
1.4e4
1.3e4
1.2e4
1.1e4
1.0e4
9000.0
8000.0
7000.0
6000.0
5000.0
4000.0
3000.0
2000.0
1000.0
0.0
3500
0.0
Intensity (cps)
lowed by on-line analysis within a 2 min injection inter-
Intensity (cps)
paration is based on a simple pretreatment step, fol-
1.6e4
0.0
Tacrolimus (Tcr)
1.3e4
0.0
d4-Everolimus
4133
0.0
Sirolimus (Srl)
3900
0.0
Everolimus (Evr)
1.7e4
0.0
1.07e4
0.0
1.1
Ascomycin
Cyclosporine A (Cyc)
1.26
m/z:
809.5 ➜ 756.6
1.28
m/z:
821.6 ➜ 768.4
1.34
m/z:
979.6 ➜ 912.6
1.34
m/z:
931.7 ➜ 864.4
1.35
m/z:
975.6 ➜ 908.4
Complete Kits
rapeutic drug monitoring (TDM) of cyclosporine A,
m/z:
1219.9 ➜ 1203.2
1.46
1.50 m/z:
1233.9 ➜ 1217.3
Cyclosporine D
0.1 0.3 0.5 0.7 0.9 1.1 1.3 1.5 1.7 1.9
1.8
Retention Time (min)
Retention Time (min)
Ordering Information
Order No.
Description
Quantity
MS1000
ClinMass® Complete Kit for Immunosuppressants in Whole Blood
for 400 assays
1 pce.
Kit Components (order no. MS1000):
Autosampler Washing Solution
SPE - Buffer
Mobile Phase
IS Internal Standard, lyoph. (contains: Ascomycin, Cyclosporine D, d4-Everolimus)
Sample Pretreatment Vials
P Precipitant
Manual
1000 ml
2 x MS1009 (2 x 1000 ml)
800 ml
3 x MS1212 (3 x 3 ml)
4 x MS1020 (4 x 100 pcs.)
80 ml
1 pce.
MS1006
MS1014
MS1015
5013
9028
9033
9933
Additional Components:
Reagent MP
Optimisation Mix 1, lyophil.
Optimisation Mix 2, lyophil.
Whole Blood Calibrator, lyophil. (single point)
Whole Blood Calibrator, lyophil. (additional level for order nos. 9033 and 9933)
Whole Blood Calibrator Set, lyophil., Level 0 - 3
Whole Blood Calibrator Set, lyophil., Level 0 - 6
8
2
3
5
2
4
7
ml
ml
ml
x2
x2
x1
x1
MS1030
MS1031
MS1032
MS1033
FK7400
Start Accessories:
Analytical Column with test chromatogram
SPE - Column
Guard Column Holder incl. 1 Guard Column
Guard Columns
Inline-Filter
1
1
1
5
1
pce.
pce.
pce.
pcs.
pce.
FK1102
FK7330
FK7340
FK7350
Accessories:
Switching valve, Sykam (6-port/3-channel, incl. electr. drive, PEEK)
Endfittings
Sealings and sieves
Endstoppers
1
2
4
2
pce.
pcs.
pcs. each
pcs.
8830
8831
8832
8833
8903
ClinChek® Controls:
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
5
5
5
3
2
x
x
x
x
x
MS1005
MS1009
MS1010
MS1212
MS1020
MS1021
lyophil.,
lyophil.,
lyophil.,
lyophil.,
lyophil.,
Level
Level
Level
Level
Level
I
II
III
I, II, III
IV, V
2
2
2
2
2
ml
ml
x 2 ml
x 2 ml
ml
ml
ml
x 2 ml
x 2 ml
123
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 124
duc
h liquid
nal pro
ion wit
t
a
r
a
Additio
p
pre
tes
well pla
sample
s and
mated
m
e
t
s
ng sy
handli
➜ Internal standard
containing isotope
labelled analytes
➜ 4- and 7-Level calibrator
set available
5.0e5
4.5e5
4.0e5
Intensity (cps)
3.5e5
3.0e5
2.5e5
2.0e5
1.0e5
Test Data
Linearity (up to):
2000 μg/l (Cyc), 80 μg/l (Tcr, Srl, Evr)
LLOD:
0.011 μg/l (Cyc), 0.004 μg/l (Tcr),
0.073 μg/l (Srl), 0.126 μg/l (Evr)
LLOQ:
0.037 μg/l (Cyc), 0.014 μg/l (Tcr),
0.244 μg/l (Srl), 0.420 μg/l (Evr)
Intraassay precision:
2.5 % (Cyc), 4.6 % (Tcr), 4.8 % (Srl), 4.9 % (Evr)
Interassay precision:
6.5 % (Cyc), 4.2 % (Tcr), 4.4 % (Srl), 4.3 % (Evr)
LC-MS/MS Parameters
LC-Parameters
Pump 1: SPE-Buffer (0.1 / 2.5 ml/min)
Pump 2: Mobile Phase (0.5 / 1.0 ml/min)
Injection volume:
50 μl
Injection interval:
2 min
Switching valve:
6-port/3-channel
(order no. FK1102)
Column heater:
60 °C
MS-Parameters
Ion source:
ESI positive
MS/MS-Mode:
MRM
7.9e4
7.0e4
6.0e4
5.0e4
4.0e4
3.0e4
2.0e4
1.0e4
0.0
5.9e5
5.5e5
1.5e5
5.0e4
0.0
1.0
1.2
1.4
1.6
1.24
Tacrolimus
13
Cd2-Tacrolimus
m/z:
821.5 ➜ 768.4
824.5 ➜ 771.5
3.0e4
2.8e4
2.4e4
2.0e4
1.6e4
1.2e4
8000.0
4000.0
0.0
1.8
1.30
Everolimus
13
C2d4-Everolimus
m/z:
975.5 ➜ 908.4
981.6 ➜ 914.7
3.1e4
2.8e4
2.4e4
2.0e4
1.6e4
1.2e4
8000.0
4000.0
0.0
5.9e5
5.0e5
1.29
Sirolimus
13
Cd3-Sirolimus
m/z:
931.5 ➜ 864.5
935.6 ➜ 864.7
1.42
Cyclosporine A
d12-Cyclosporine A
4.0e5
m/z:
1219.7 ➜ 1202.9
1232.0 ➜ 1215.0
3.0e5
2.0e5
1.0e5
0.0
0.2 0.6 1.0 1.4 1.8
0.2 0.6 1.0 1.4 1.8
Retention Time (min)
Retention Time (min)
Ordering Information
Order No.
Description
Quantity
MS1100
ClinMass® Complete Kit, advanced, for Immunosuppressants in Whole Blood
for 400 assays
1 pce.
MS1005
MS1009
MS1010
MS1412
MS1020
MS1021
Kit Components (order no. MS1100):
Autosampler Washing Solution
SPE-Buffer
Mobile Phase
IS Internal Standard, lyophil.
Sample Pretreatment Vials
P Precipitant
Manual
1000 ml
2 x MS1009 (2 x 1000 ml)
800 ml
3 x MS1412 (3 x 3 ml)
4 x MS1020 (4 x 100 pcs.)
80 ml
MS1006
MS1014
MS1115
5013
9028
9033
9933
Additional Components:
Reagent MP
Optimisation Mix 1, lyophil.
Optimisation Mix 2, lyophil.
Whole Blood Calibrator, lyophil. (single point)
Whole Blood Calibrator, lyophil. (additional level for order nos. 9033 and 9933)
Whole Blood Calibrator Set, lyophil. (Level 0 - 3)
Whole Blood Calibrator Set, lyophil. (Level 0 - 6)
8
2
2
5
2
4
7
ml
ml
ml
x2
x2
x1
x1
MS1030
MS1031
MS1032
MS1033
FK7400
Start Accessories:
Analytical Column with test chromatogram
SPE-Column
Guard Column Holder incl. 1 Guard Column
Guard Column
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
5
1
pce.
pce.
pce.
pcs.
pce.
FK1102
FK7330
FK7340
FK7350
Accessories:
Switching valve Sykam (6-port/3-channel incl. electr. drive, PEEK)
Endfittings
Sealings and sieves
Endstoppers
1
2
4
2
pce.
pcs.
pcs. each
pcs.
8830
8831
8832
8833
8903
ClinChek® Controls:
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
Whole Blood Control,
5
5
5
3
2
x
x
x
x
x
ml
ml
x 2 ml
x 2 ml
Sample Pretreatment
Precipitation:
200 μl
Precipitant P
20 μl Internal
Standard IS
➜
➜ No matrix effects
Immunosuppressants
in Whole Blood,
advanced –
On-Line Analysis
Chromatogram (left) and mass traces (right) of the ClinCal® Whole Blood Calibrator (order no. 9933), level 4
Complete Kits
on:
ble so fully autoa
l
i
a
v
A
t for a
Immunosuppressants
Intensity (cps)
This ClinMass® Complete Kit is an advancement of
our reliable complete kit with order no. MS1000
(see pages 122 - 123) and provides an improved
chromatographical performance. For analysis a new
internal standard with the isotope labelled analytes
d12-cyclosporine A, 13Cd2-tacrolimus, 13Cd3-sirolimus
und 13C2d4-everolimus is available. Thus, matrix
effects are excluded. As with our previous kit, the
sample preparation is based on a simple pretreatment step, followed by on-line analysis within a 2 min
injection interval.
On-Line Analysis:
100 μl whole blood
(calibrator, control,
patient)
1. mix and incubate
(ambient temperature)
2. mix and centrifuge
Inject 50 μl of the supernatant
lyophil.,
lyophil.,
lyophil.,
lyophil.,
lyophil.,
Level
Level
Level
Level
Level
I
II
III
I, II, III
IV, V
2
2
2
2
2
ml
ml
ml
x 2 ml
x 2 ml
125
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 126
Chromatogram (left) and mass traces (right) of the ClinCal® Serum Calibrator, Level 3 (order no. MS2013)
Test Data
Linearity:
0.1 - 106 μmol/l
LLOD:
0.01 μmol/l
LLOQ:
0.1 μmol/l
Intraassay precision: 1.9 %
Interassay precision: 4.8 %
LC-MS/MS Parameters
LC-Parameters
Pump:
isocratic (0.7 ml/min)
Injection volume:
1 μl
Injection interval:
1.0 min
Column heater:
room temperature
MS-Parameters
Ion source:
MS/MS-Mode:
ESI, positive
MRM
Sample Preparation
Reduction:
50 μl sample
(+ 50 μl Internal Standard IS)
➜
Precipitation:
➜
➜ Simple and quick two-step
sample preparation
0.74
0.6 0.65 0.7 0.75 0.8 0.85 0.9 0.95 1.0
Retention Time (min)
4.0e5
3.5e5
3.0e5
2.5e5
2.0e5
1.5e5
1.0e5
5.0e4
0.00
Homocysteine
m/z: 136.1 ➜ 90.1
0.73
3.0e5
2.5e5
2.0e5
1.5e5
1.0e5
5.0e4
0.00
d4-Homocysteine
m/z: 140.1 ➜ 94.1
0.55
0.65
0.75
0.85
0.95
Retention Time (min)
Ordering Information
Order No.
Description
MS2000
ClinMass® Complete Kit for Homocysteine in Plasma / Serum
for 300 assays
MS2005
MS2010
MS2012
MS2013
MS2020
MS2021
MS2022
Kit Components (order no. MS2000):
Autosampler Washing Solution
Mobile Phase
IS Internal Standard, lyophil.
Serum Calibrator Set, lyophil. (Level 0 - 3)
Sample Preparation Vials
Reagent A
Reagent B
Manual
1 pce.
1000 ml
800 ml
3 x MS2012
4 x 1 x 1 ml
3 x MS2020
3 x MS2021
2 x MS2022
(3 x 5 ml)
(3 x 100 pcs.)
(3 x 5 ml)
(2 x 30 ml)
50 μl Reagent A
mix, incubate
(room temperature, 5 min)
200 μl Reagent B
LC-MS/MS Analysis:
0.74
4.8e5
4.6e5
4.4e5
4.2e5
4.0e5
3.8e5
3.6e5
3.4e5
3.2e5
3.0e5
2.8e5
2.6e5
2.4e5
2.2e5
2.0e5
1.8e5
1.6e5
1.4e5
1.2e5
1.0e5
8.0e4
6.0e4
4.0e4
2.0e4
0.00
Complete Kits
Homocysteine
in Plasma / Serum
Intensity (cps)
Metabolic Disease
Intensity (cps)
Homocysteine is an established parameter for the
risk assessment of degenerative vascular diseases,
which may lead to heart attack, stroke and thrombosis. The RECIPE ClinMass® Complete Kit allows
a reliable determination of total homocysteine for
the detection of hyperhomocysteinemia. After an
easy sample preparation (reduction and precipitation step) the samples are analysed with an injection interval of 1.0 min only.
Optionally, the sample preparation can be performed
fully automated with liquid handling systems and
96-well plates.
1. mix, incubate (4 °C, 5 min)
2. centrifuge
Inject 1 μl of the supernatant
MS2030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK6500
FK6510
FK6511
Accessories:
Protective sheets for 96-well-plate (aluminium foil, 80 x 140 mm)
96-Well-Plates (370 μl)
96-Well-Plates (1200 μl)
100 pcs.
5 pcs.
5 pcs.
23080
23081
23082
ClinChek® Controls:
Plasma Control, lyophil., Level I
Plasma Control, lyophil., Level II
Plasma Control, lyophil., Level I, II
10 x 3 ml
10 x 3 ml
2 x 5 x 3 ml
➜ Injection interval: 1.0 min
➜ Optional: method with
automated sample
preparation (96-well plates)
127
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 128
Chromatogram (left) and mass traces (right) of the ClinCal® Whole Blood Calibrator (DBS), Level 3 (order no. MS2113)
Test Data
Linearity:
0.2 - 104 μmol/l
LLOD:
0.07 μmol/l
LLOQ:
0.2 μmol/l
Intraassay precision: 2.8 %
Interassay precision: 3.8 %
LC-MS/MS Parameters
LC-Parameters
Pump:
isocratic (0.7 ml/min)
Injection volume:
1 μl
Injection interval:
1.0 min
Column heater:
room temperature
MS-Parameters
Ion source:
MS/MS-Mode:
ESI, positive
MRM
Sample Preparation
Reduction:
Filter Spot Sample
(+ 15 μl Internal Standard)
2.5e4
2.4e4
2.3e4
2.2e4
2.1e4
2.0e4
1.9e4
1.8e4
1.7e4
1.6e4
1.5e4
1.4e4
1.3e4
1.2e4
1.1e4
1.0e4
9000.0
8000.0
7000.0
6000.0
5000.0
4000.0
3000.0
2000.0
1000.0
0.0
0.50
0.66
0.74
0.82
0.90
0.98
2.5e4
2.1e4
1.8e4
1.5e4
1.2e4
9000.0
6000.0
3000.0
0.0
0.71
2.3e4
2.1e4
1.8e4
1.5e4
1.2e4
9000.0
6000.0
3000.0
0.0
0.71
Homocysteine
m/z: 136.1 ➜ 90.1
d4-Homocysteine
m/z: 140.1 ➜ 94.1
0.50 0.60 0.70 0.80 0.90 0.98
Retention Time (min)
Ordering Information
Order No.
Description
Quantity
MS2100
ClinMass® Complete Kit for Homocysteine in Whole Blood (DBS)
for 300 assays
1 pce.
MS2005
MS2010
MS2112
MS2113
MS2020
MS2021
MS2022
15 μl Reagent A
Kit Components (order no. MS2100):
Autosampler Washing Solution
Mobile Phase
IS Internal Standard, lyophil.
Whole Blood Calibrator Set (filter spots, Level 0 - 3)
Sample Preparation Vials
Reagent A
Reagent B
Manual
1000 ml
800 ml
5 ml
4 x 1 x 3 spots
3 x MS2020 (3 x 100 pcs.)
5 ml
30 ml
➜
MS2030
Start Accessories:
Analytical Column with test chromatogram
1 pce.
FK6500
FK6510
MS2170
Accessories:
Protective sheets for 96-well-plate (aluminium foil, 80 x 140 mm)
96-Well-Plates (370 μl)
Filter Testcards
100 pcs.
5 pcs.
100 pcs.
MS2182
ClinChek® Controls:
Whole Blood Control (filter spots), Level I, II
mix
100 μl Reagent B
➜
LC-MS/MS Analysis:
0.58
Retention Time (min)
Precipitation:
➜ Simple and quick two-step
sample preparation
0.71
Complete Kits
Homocysteine
in Whole Blood (DBS)
Intensity (cps)
Metabolic Disease
Intensity (cps)
The determination of homocysteine from dried blood
spots (DBS) is used for the newborn screening for
inherited defects of the methionine metabolism
(homocystinuria). The RECIPE ClinMass® Complete
Kit allows a reliable determination of total homocysteine from filter spots. The easy sample preparation
(reduction and precipitation step) is followed by the
sample analysis with an injection interval of 1.0 min
only. For blood collection suitable filter test cards
are available.
Optionally, the sample preparation can be performed
fully automated with liquid handling systems and
96-well plates.
1. mix
2. centrifuge
2 x 1 x 3 spots
Inject 1 μl of the supernatant
➜ Injection interval: 1.0 min
➜ Optional: method with
automated sample
preparation (96-well plates)
129
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Benzodiazepines are a class of psychoactive drugs,
Psychoactive Drugs
Chromatogram of the ClinCal® Serum Calibrator, Level 1 (order no. MS6013)
which are widely prescribed to treat conditions such
as anxiety and insomnia. The chronic administration
allows for the routine analysis of 33 different benzodiazepines and metabolites. No manual sample preparation is required. The serum sample is directly
Benzodiazepines
in Serum –
On-Line Analysis
injected; the Internal Standard IS added by an autosampler injector program and the sample preparation
performed on-line by solid phase extraction (SPE).
The entire run time is 11 minutes, including sample
clean-up, LC-MS/MS analysis and column regeneration,
enabled by automated column switching.
Test Data
Test data are available on request.
LC-MS/MS Parameters
LC-Parameters
Isocratic HPLC pump: SPE Buffer
(0.1 / 1.5 / 5.0 ml/min)
Binary HPLC pump: Mobile Phases A/B
(0.7 ml/min)
Injection volume:
20 μl
Injection interval:
11 min
Switching valve:
6-port/3-channel
(order no. FK1103)
Column heater:
30 °C
MS-Parameters
Ion source:
Heated Nebulizer (APcI),
positive
MS/MS mode:
MRM
On-Line Analysis
Injection of 10 μl sample +
10 μl Internal Standard IS*
* contains 20 isotope labeled compounds
➜ Quantification of
33 analytes
➜ On-line sample
preparation
5.1e5
7-Aminoclonazepam
7-Aminonitrazepam
7-Aminoflunitrazepam
Zaleplon
Demoxepam
Bromazepam
Desmethylflunitrazepam
Norclobazam
α-OH-Triazolam
Clonazepam
Flunitrazepam
Nitrazepam
α-OH-Alprazolam
Estazolam
Clobazam
Triazolam
Lorazepam
3.0e5
2.8e5
2.6e5
2.4e5
2.2e5
2.0e5
1.8e5
1.6e5
1.4e5
1.2e5
1.0e5
8.0e4
6.0e4
4.0e4
2.0e4
0.0
3.5
4.5
5.5
6.5
7.5
8.5
9.5
3.96
3.96
4.13
4.86
5.12
5.27
5.27
5.43
5.44
5.59
5.64
5.66
5.75
5.81
5.86
6.01
6.13
Alprazolam
Oxazepam
Desalkylflurazepam
Zolpidem
Temazepam
α-OH-Midazolam
Lormetazepam
Chlordiazepoxide
Nordiazepam
Midazolam
Diazepam
Flurazepam
Trazodone
Tetrazepam
Prazepam
Medazepam
6.21
6.23
6.54
6.56
6.64
6.81
6.84
7.21
7.51
7.93
7.98
8.55
8.74
9.19
9.23
9.67
Complete Kits
toring. For this purpose, the ClinMass Complete Kit
®
Intensity (cps)
of benzodiazepines may require therapeutic drug moni-
10.5
Retention Time (min)
Ordering Information
Order No.
Description
Quantity
MS6000
ClinMass® Complete Kit for Benzodiazepines in Serum
for 200 assays
1 pce.
MS6005
MS6007
MS6008
MS6009
MS6012
MS6013
Kit Components (order no. MS6000):
Autosampler Washing Solution
Mobile Phase A
Mobile Phase B
SPE - Buffer
IS Internal Standard, lyophil.
Serum Calibrator Set, lyophil., Level 0 - 3
Manual
1000 ml
1000 ml
1000 ml
2 x MS6009 (2 x 1000 ml)
5 x MS6012 (5 x 2 ml)
4 x 1 x 1 ml
1 pce.
Additional Components
MS6015 MS6019
Optimisation Mix 1 - 5, lyophil.
2 ml, each
MS6030
MS6031
MS6032
MS6033
FK7400
Start Accessories:
Analytical Column with test chromatogram
SPE - Column
Guard Column Holder incl. 1 Guard Column
Guard Column
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
5
1
pce.
pce.
pce.
pcs.
pce.
FK1103
FK7330
FK7340
FK7350
Accessories:
Switching valve, Sykam (6-port/3-channel incl. electr. drive, steel)
Endfittings
Sealings and sieves
Endstoppers
1
2
4
2
pce.
pcs.
pcs., each
pcs.
MS6082
ClinChek® Controls:
Serum Control, lyophil., Level I, II
2 x 5 x 1 ml
➜ Injection interval: 11 min
131
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:33 Seite 132
Methylmalonic acid (MMA) serves for the assessment of
Chromatogram of the ClinChek® Serum Control, Level I (order no. MS5080)
Vitamin Status
the vitamin B12 status. Vitamin B12 deficiency leads to an
increased MMA concentration in serum, plasma and urine.
preparation with only one pipetting step (serum, plasma)
or direct injection of samples after dilution and addition
of IS (urine). The subsequent LC-MS/MS analysis is performed within a 2 min injection interval only while the isobar component succinic acid, which may interfere with
MMA, is separated reliably. Calibration and quality control is performed in a convenient and cost-efficient way.
The method is fully validated using only one (serum) calibration and control set for all three sample matrices
(ClinCal® 4-Level Calibrator Set and ClinChek® Controls).
Test Data
Linearity:
– Serum, Plasma:
– Urine:
LLOD:
– Serum, Plasma:
– Urine:
LLOQ:
– Serum, Plasma:
– Urine:
Intraassay precision:
Interassay precision:
25 - 67745 nmol/l
651 - 1426200 nmol/l
25 nmol/l
651 nmol/l
4.3 %
5.1 %
Sample Preparation
Precipitation / Addition of IS:
400 μl P Precipitant
(contains internal standard)
➜ Reliable separation
of succinic acid
➜
LC-MS/MS Analysis:
Succinic Acid
1.50
d3-Methylmalonic Acid
m/z: 119.9 ➜ 76
Methylmalonic Acid
m/z: 116.9 ➜ 73
0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0
15 nmol/l
391 nmol/l
LC-MS/MS Parameters
LC-Parameters
Binary gradient pump: Mobile Phase A / B
(0.7 ml/min)
Injection volume:
2 - 5 μl
Injection interval:
2.0 min
Column heater:
25 °C
MS-Parameters
Ion source:
Turbo-ionspray (TIS) ESI,
negative
MS/MS-Mode:
MRM
➜ One-step sample preparation (serum / plasma)
0.56
1.02e4
1.00e4
9500.00
9000.00
8500.00
8000.00
7500.00
7000.00
6500.00
6000.00
5500.00
5000.00
4500.00
4000.00
3500.00
3000.00
2500.00
2000.00
1500.00
1000.00
500.00
0.00
Complete Kits
and time saving MMA analysis featuring short sample
Methylmalonic Acid
in Serum / Plasma /
Urine, advanced
Intensity (cps)
This new RECIPE ClinMass® Complete Kit provides a fast
Retention Time (min)
Ordering Information
Order No.
Description
Quantity
MS5100
ClinMass® Complete Kit, advanced, for Methylmalonic Acid in Serum / Plasma / Urine
for 300 assays
1 pce.
Kit Components (order no. MS5100):
Autosampler Washing Solution
Mobile Phase A
Mobile Phase B
P Precipitant with Internal Standard
Serum Calibrator Set, lyophil., (Level 0 - 3)
Sample Preparation Vials
Manual
1000 ml
1000 ml
200 ml
3 x MS5112 (3 x 40 ml)
4 x 1 x 2 ml
3 x MS5020 (3 x 100 pcs.)
1 pce.
MS5114
MS5021
Additional Components:
Optimisation Mix
D Diluting Solution for Urine
2 ml
50 ml
MS5130
Start Accessories:
Analytical Column with test chromatogram
1 pce.
MS5080
MS5081
MS5082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 2 ml
10 x 2 ml
2 x 5 x 2 ml
MS5005
MS5108
MS5109
MS5112
MS5013
MS5020
100 μl sample*
(calibrator, control, patient)
mix and centrifuge
Inject 2 - 5 μl of the sample
* Urines are diluted (50 μl urine + 1000 μl Diluting Solution D)
➜ Injection interval: 2 min
133
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Vitamin Status
on-line analysis of 25-OH vitamin D (D2, D3) with an
25-OH-Vit D2
injection interval of 3 min only. In order to avoid false
from the analyte peak. An analytical column with a run
time of 4 min (order no. MS7035) is additionally available in order to obtain base line separation.
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25-OH Vitamin D2 / D3
in Plasma and Serum –
On-Line Analysis
- 250 μg/l (D2)
- 250 μg/l (D3)
μg/l (D2)
μg/l (D3)
μg/l (D2)
μg/l (D3)
% (D2)
% (D3)
% (D2)
% (D3)
➜ Traceable to NIST
standard SRM 972a
Precipitation:
50 μl sample
(calibrator, control, patient)
➜
➜ Separation of the
C-3 epimer
100
MS7030
Vit D3
7000
2500
6000
2000
2000
1500
3-epi Vit D3
5000
4000
1500
1000
3000
1000
0
2.5
3.0
100
MS7035
Vit D3
1. mix, incubate (4 °C)
2. mix, centrifuge
Inject 10 - 50 μl
500
0
3.0
3-epi Vit D3
1000
0
2.5
0
0
2.5
3.0
2.5
3.0
Retention Time (min)
left:
right:
3.6
4.1
Retention Time (min)
ClinCal® Serum Calibrator, order no. MS7013, level 2 (25-OH vitamin D2 and D3) and
ClinMass® Internal Standard, order no. MS7012 (d6-25-OH vitamin D3)
Human serum with 25-OH vitamin D3 and 3-epi-25-OH vitamin D3, measured with the
3-min method (top) and 4-min method (bottom)
Ordering Information
Order No.
Description
Quantity
MS7000
ClinMass® Complete Kit for 25-OH Vitamin D2 / D3 in Plasma and Serum
for 300 assays
1 pce.
MS7005
MS7009
MS7010
MS7012
MS7013
MS7020
MS7021
MS7014
MS7015
Kit Components (order no. MS7000):
Autosampler Washing Solution
SPE-Buffer
Mobile Phase
IS Internal Standard
Serum Calibrator Set, lyophil. (Level 0 - 3)
Sample Pretreatment Vials
P Precipitant
Manual
Additional Components:
Optimisation Mix
Optimisation Mix 3-epi
1000 ml
2 x MS7009 (2 x 1000 ml)
700 ml
30 ml
4 x 1 x 1 ml
3 x MS7020 (3 x 100 pcs.)
15 ml
2 ml
1 ml
MS7031
FK7400
Start Accessories:
Analytical Column with test chromatogram
Analytical Column 3-epi with test chromatogram
(for the additional analysis of 3-epi-25-OH Vitamin D3)
SPE-Column
Inline-Filter (stainless steel sieve, free of dead volume)
1 pce.
1 pce.
FK1102
FK7330
FK7340
FK7350
Accessories:
Switching valve Sykam (6-port/3-channel incl. electr. drive, PEEK)
Endfittings
Sealings and sieves
Endstoppers
1
2
4
2
MS7080
MS7081
MS7082
ClinChek® Controls:
Serum Control, lyophil., Level I
Serum Control, lyophil., Level II
Serum Control, lyophil., Level I, II
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
MS7030
MS7035
Sample Pretreatment
On-Line Analysis:
2500
500
1.4
2.3
LLOD:
0.4
0.7
LLOQ:
1.4
2.3
Intraassay precision: 6.8
4.7
Interassay precision: 7.6
6.6
150 μl
mixture IS/P
2.65
8000
3000
2000
Test Data
Linearity:
LC-MS/MS Parameters
LC-Parameters
Pump 1:
SPE-Buffer (0.1 - 5.0 ml/min)
Pump 2:
Mobile Phase (0.5 ml/min)
Injection volume:
10 - 50 μl
Injection interval:
3 min (4 min)
Switching valve:
6-port/3-channel
(order no. FK1102)
Column heater:
40 °C
MS-Parameters
Ion source:
Heated Nebulizer (APcI),
positive
MS/MS-Mode:
MRM
➜ Fast on-line analysis
(injection interval: 3 min)
2.65
Complete Kits
min D3 (3-epi-25-OH vitamin D3) is separated reliably
Intensity (cps)
high analytical values, the C-3 epimer of 25-OH vita-
2895
d6-25-OH-Vit D3
25-OH-Vit D3
2.69
Intensity (%)
This ClinMass® LC-MS/MS Complete Kit enables a fast
1 pce.
1 pce.
pce.
pcs.
pcs. each
pcs.
135
Opti Mix, IS
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LC-MS/MS
ClinMass®
Optimisation Mixes
ClinMass®
Internal Standards
. . . . 138 - 139
. . . . . 140 - 141
137
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Product Survey, Optimisation Mixes
Antiretrovirals
Immunosuppressants
■ Analytes:
■ Analytes:
Amprenavir, atazanavir, darunavir, delavirdine, efavirenz, etravirine, indinavir, lopinavir,
Cyclosporine A, everolimus, sirolimus, tacrolimus
maraviroc, nelfinavir, nevirapine, raltegravir, ritonavir, saquinavir, tipranavir
Order no.
Description
MS1014
ClinMass Optimisation Mix 1, lyophil., for Immunosuppressants
Order no.
Description
MS4014
ClinMass® Optimisation Mix, ready for use, for Antiretrovirals
Quantity
2 ml
®
Quantity
2 ml
(for ClinMass® Complete Kits with order nos. MS1000 and MS1100)
■ Analytes:
Benzodiazepines
Ascomycin, cyclosporine D, d4-everolimus
■ Analytes:
Order no.
Description
7-Aminoflunitrazepam, 7-aminonitrazepam, demoxepam, flunitrazepam, prazepam,
MS1015
ClinMass Optimisation Mix 2, lyophil., for Immunosuppressants
®
Quantity
3 ml
Order no.
Description
MS6015
ClinMass® Optimisation Mix 1, lyophil., for Benzodiazepines
Opti Mix, IS
(for ClinMass® Complete Kit with order no. MS1000)
temazepam
Quantity
2 ml
■ Analytes:
d12-Cyclosporine A, 13C2d4-everolimus, 13Cd3-sirolimus, 13Cd2-tacrolimus
■ Analytes:
Order no.
Description
Bromazepam, clobazam, lormetazepam, nitrazepam, norclobazam, nordiazepam
MS1115
ClinMass® Optimisation Mix 2, lyophil., for Immunosuppressants
Order no.
Description
MS6016
ClinMass® Optimisation Mix 2, lyophil., for Benzodiazepines
Quantity
2 ml
(for ClinMass® Complete Kit with order no. MS1100)
Quantity
2 ml
■ Analytes:
Methylmalonic Acid
Alprazolam, 7-aminoclonazepam, clonazepam, α-hydroxymidazolam, medazepam,
■ Analytes:
midazolam, norflunitrazepam, tetrazepam
Methylmalonic acid, d3-methylmalonic acid
Order no.
Description
MS6017
ClinMass® Optimisation Mix 3, lyophil., for Benzodiazepines
Quantity
2 ml
Order no.
Description
MS5114
ClinMass® Optimisation Mix, ready for use, for Methylmalonic Acid
Quantity
2 ml
(for ClinMass® Complete Kit with order no. MS5100)
■ Analytes:
Chlordiazepoxide, desalkylflurazepam, diazepam, flurazepam, α-hydroxyalprazolam,
25-OH Vitamin D2 / D3
trazodone, zolpidem
Order no.
Description
MS6018
ClinMass® Optimisation Mix 4, lyophil., for Benzodiazepines
Quantity
2 ml
■ Analytes:
■ Analytes:
25-Hydroxy-vitamin D2, 25-hydroxy-vitamin D3, d6-25-hydroxy-vitamin D3
Order no.
Description
MS7014
ClinMass® Optimisation Mix, ready for use, for 25-OH Vitamin D2 / D3
Quantity
2 ml
Estazolam, α-hydroxytriazolam, lorazepam, oxazepam, triazolam, zaleplone
Order no.
Description
MS6019
ClinMass® Optimisation Mix 5, lyophil., for Benzodiazepines
Quantity
2 ml
(Order nos. MS6015 - MS6019: for ClinMass® Complete Kit with order no. MS6000)
■ Analytes:
25-Hydroxy-vitamin D3, 3-epi-25-hydroxy-vitamin D3
Order no.
Description
MS7015
ClinMass® Optimisation Mix, ready for use, for 25-OH Vitamin D3
Quantity
1 ml
and C-3 Epimer
Ethylglucuronide
(Order nos. MS7014 - MS7015: for ClinMass® Complete Kit with order no. MS7000)
■ Analytes:
Ethylglucuronide, d5-ethylglucuronide, ethylsulfate, d5-ethylsulfate
Order no.
Description
MS8014
ClinMass Optimisation Mix, ready for use, for Ethylglucuronide
®
Quantity
2 ml
(for ClinMass® Complete Kit with order no. MS8000/MS8100)
138
139
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Product Survey, Internal Standards
Antiretrovirals
Immunosuppressants
■ Analytes:
■ Analytes:
d4-Amprenavir, d5-atazanavir, d9-darunavir, d4-efavirenz, d8-etravirine, d6-indinavir,
Cyclosporine D
d8-lopinavir, d6-maraviroc, d3-nelfinavir, d5-nevirapine, d3-raltegravir, d6-ritonavir,
Order no.
Description
d6-saquinavir, d4-tipranavir
MS1112
ClinMass Internal Standard, lyophil., for Immunosuppressants
Order no.
Description
MS4012
ClinMass® Internal Standard, ready for use, for Antiretrovirals
Quantity
25 μg
®
Quantity
2 ml
■ Analytes:
Ascomycin, cyclosporine D, d4-everolimus
Benzodiazepines
Order no.
Description
MS1212
ClinMass® Internal Standard, lyophil., for Immunosuppressants
■ Analytes:
Quantity
3 ml
(for ClinMass Complete Kit with order no. MS1000)
®
d4-clonazepam, d5-diazepam, d5-estazolam, d7-flunitrazepam, d5-α-hydroxyalprazolam,
■ Analytes:
d4-α-hydroxymidazolam, d4-α-hydroxytriazolam, d4-lorazepam, d4-midazolam,
d12-Cyclosporine A, 13C2d4-everolimus, 13Cd3-sirolimus, 13Cd2-tacrolimus
d5-nitrazepam, d5-nordiazepam, d5-oxazepam, d5-prazepam, d5-temazepam,
Order no.
Description
d4-triazolam, d6-zolpidem
MS1312
ClinMass Internal Standard, lyophil., for Immunosuppressants
Order no.
Description
MS6012
ClinMass® Internal Standard, lyophil., for Benzodiazepines
Quantity
(for ClinMass Complete Kit with order no. MS6000)
6.25 / 0.5 /
®
Quantity
2 ml
Opti Mix, IS
d5-Alprazolam, d4-7-aminoclonazepam, d7-7-aminoflunitrazepam, d5-chlordiazepoxide,
0.5 / 0.5 μg
■ Analytes:
d12-Cyclosporine A, 13C2d4-everolimus, 13Cd3-sirolimus, 13Cd2-tacrolimus
®
Order no.
Description
MS1412
ClinMass Internal Standard, lyophil., for Immunosuppressants
Ethylglucuronide
Quantity
®
3 ml
(for ClinMass® Complete Kit with order no. MS1100)
■ Analytes:
d5-Ethylglucuronide, d5-ethylsulfate
Order no.
Description
MS8012
ClinMass® Internal Standard, ready for use, for Ethylglucuronide
Quantity
100 ml
(for ClinMass Complete Kit with order no. MS8000)
ClinMass® Internal Standard, ready for use, for Ethylglucuronide
■ Analytes:
d3-Methylmalonic acid
®
MS8112
Methylmalonic Acid
30 ml
(for ClinMass Complete Kit with order no. MS8100)
®
Order no.
Description
Quantity
MS5112
ClinMass Internal Standard, lyophil., for Methylmalonic Acid
®
40 ml
(in Precipitant, for ClinMass® Complete Kit with order no. MS5100)
Homocysteine
■ Analytes:
Nicotine and Metabolites
d8-Homocystine
■ Analytes:
Order no.
Description
MS2012
ClinMass® Internal Standard, lyophil., for Homocysteine
Quantity
5 ml
(for ClinMass Complete Kit with order no. MS2000)
®
MS2112
ClinMass® Internal Standard, lyophil., for Homocysteine
d3-Cotinine, d3-hydroxycotinine, d3-nicotine
Order no.
Description
Quantity
MS3012
ClinMass Internal Standard, ready for use, for Nicotine and Metabolites
®
1.5 ml
5 ml
(for ClinMass® Complete Kit with order no. MS2100)
25-OH Vitamin D2 / D3
■ Analytes:
140
Immunosuppressants
d6-25-Hydroxy-vitamin D3
■ Analytes:
Order no.
Description
Ascomycin
MS7012
ClinMass® Internal Standard, ready for use, for 25-OH Vitamin D2 / D3
Order no.
Description
MS1012
ClinMass® Internal Standard, lyophil., for Immunosuppressants
30 ml
(for ClinMass Complete Kit with order no. MS7000)
Quantity
2 μg
Quantity
®
MS7112
ClinMass® Internal Standard, lyophil., for 25-OH Vitamin D2 / D3
2 μg
141
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Quality Assurance
Quality Assurance
ClinTest® Solutions
ClinCal® Calibrators
ClinChek® Controls
RECIPE provides a wide range of IVD/CE labelled
test and reference materials. Our products help to
ensure a coherent QA process including the testing of the analytical system (ClinTest®), calibration
(ClinCal®) and quality control (ClinChek®).
ClinTest® Standard and Test Solutions are matrixfree and thus are ready to use. ClinCal® Calibrators
and ClinChek® Controls are available in different
matrices (urine, plasma, serum, whole blood) and
are prepared for analysis like the patient samples.
le:
availab ml
s
e
t
a
d
t
eet up
ates.h
Datash e.de/en/upd
ecip
www.r
143
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Quality Assurance
. . . . . 146 - 151
ClinTest®
ClinTest® Solutions
145
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ClinTest® Standard and Test Solutions
Amiodarone
Atypical Neuroleptics
■ Analytes:
■ Analytes:
Amiodarone, desethylamiodarone, internal standard
Clozapine, desmethylclozapine, desmethylolanzapine, internal standard, olanzapine,
Order no.
Description
20011
ClinTest® Standard Solution, ready for use, for Amiodarone
Quantity
quetiapine
1 x 3 ml
Order no.
Description
40014
ClinTest Test Solution, lyophil., for Atypical Neuroleptics
®
Antiasthmatics
■ Analytes:
■ Analytes:
Paliperidone (9-OH-risperidone), risperidone
Caffeine, internal standard, theobromine, theophylline
Order no.
Description
12011
ClinTest® Standard Solution, ready for use, for Antiasthmatics
Quantity
Quantity
5 x 2 ml
Order no.
Description
Quantity
40114
ClinTest® Test Solution, ready for use, for Risperidone, Paliperidone
1 x 15 ml
1 x 4 ml
Antiepileptics
■ Analytes:
■ Analytes:
6-Acetylmorphine, amphetamine, codeine, EDDP, internal standard, MDA, methadone,
Carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide, ethosuximide,
morphine, tilidine
10-hydroxy-carbamazepine, internal standard, oxcarbazepine, PEMA, phenobarbital,
Order no.
Description
phenytoin, primidone
60014
ClinTest® TOX.I.S.TM Test Solution, ready for use, for Basic Drugs in Urine 1 x 15 ml
Order no.
Description
15011
ClinTest® Standard Solution, ready for use, Antiepileptics
ClinTest®
Basic Drugs (TOX.I.S.TM)
Quantity
Quantity
1 x 3 ml
β-Carotene
■ Analytes:
■ Analytes:
Carbamazepine, carbamazepine-epoxide, ethosuximide, internal standard,
See title
10-hydroxy-carbamazepine, lamotrigine, oxcarbazepine, phenobarbital, phenytoin,
Order no.
Description
primidone, sulthiame
30014
ClinTest® Test Solution, lyophil., for β-Carotene
Order no.
Description
14011
ClinTest® Standard Solution, ready for use, Antiepileptics 3
Quantity
1 x 3 ml
Quantity
1 x 3 ml
Catecholamines
■ Analytes:
■ Analytes:
N-Desmethylmethsuximide, felbamate, internal standard, lacosamide, rufinamide,
Dopamine, epinephrine, internal standard, norepinephrine
zonisamide
Order no.
Description
Quantity
1011
ClinTest Standard Solution, ready for use, for Catecholamines
1 x 10 ml
Order no.
Description
14111
ClinTest® Standard Solution, ready for use, Antiepileptics 4
Quantity
1 x 3 ml
®
in Plasma
2011
ClinTest® Standard Solution, ready for use, for Catecholamines
1 x 10 ml
in Urine
CDT
■ Analytes:
A-, mono-, di-, tri-, tetra-, penta-, hexasialotransferrin
146
Order no.
Description
Quantity
21014
ClinTest® Test Solution, ready for use, for CDT
1 x 15 ml
147
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ClinTest® Standard and Test Solutions
Coenzyme Q10
Lamotrigine and Sulthiame
■ Analytes:
■ Analytes:
Coenzyme Q10 (ubiquinone), internal standard
Internal standard 1, internal standard 2, lamotrigine, sulthiame
Order no.
Description
31014
ClinTest® Test Solution, ready for use, for Coenzyme Q10
Quantity
1 x 3 ml
Order no.
Description
15111
ClinTest® Standard Solution, ready for use,
Quantity
1 x 3 ml
for Lamotrigine and Sulthiame
Hemoglobin A1c
■ Analytes:
Levetiracetam (Keppra®)
■ Analytes:
See title
Order no.
Description
Quantity
Internal standard, levetiracetam
11011
ClinTest® Reference Standard, ready for use, for HbA1c
10 x 5 ml
Order no.
Description
15511
ClinTest® Standard Solution, ready for use, for Levetiracetam
Quantity
1 x 3 ml
Hemoglobin Variants
■ Analytes:
Metanephrines
Order no.
Description
13114
ClinTest® Test Solution, ready for use, for Hemoglobin Variants
Quantity
5 x 3 ml
ClinTest®
■ Analytes:
Hemoglobin A0, A1c, A2, C, D, E, F, S
Internal standard, metanephrine, 3-methoxytyramine, normetanephrine
Order no.
Description
Quantity
4011
ClinTest Standard Solution, ready for use, for Metanephrines
1 x 10 ml
®
Hippuric Acids
■ Analytes:
t,t-Muconic Acid
Hippuric acid, internal standard, m-methyl-hippuric acid, o-methyl-hippuric acid
■ Analytes:
Order no.
Description
52011
ClinTest® Standard Solution, ready for use, for Hippuric Acids
Quantity
1 x 3 ml
Internal standard, t,t-muconic acid
Order no.
Description
51011
ClinTest® Standard Solution, ready for use, for t,t-Muconic Acid
Quantity
1 x 3 ml
Homocysteine
■ Analytes:
Mycophenolic Acid
■ Analytes:
Cysteine, cysteinylglycine, homocysteine, internal standard
Order no.
Description
23011
ClinTest® Standard Solution, ready for use, for Homocysteine
Quantity
1 x 3 ml
Internal standard, mycophenolic acid
Order no.
Description
29014
ClinTest® Test Solution, ready for use, for Mycophenolic Acid
Quantity
1 x 3 ml
Hydroxyproline
■ Analytes:
Pharmaceuticals (TOX.I.S.TM)
■ Analytes:
Hydroxyproline, internal standard
148
Order no.
Description
16011
ClinTest® Standard Solution, ready for use, for Hydroxyproline
Quantity
1 x 5 ml
Carbamazepine, doxepin, doxylamine, internal standard, norclozapine,
oxazepam, temazepam
Order no.
Description
Quantity
60114
ClinTest® TOX.I.S.TM Test Solution, ready for use, for Pharmaceuticals
1 x 15 ml
149
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ClinTest® Standard and Test Solutions
Porphyrins
Vitamin C
■ Analytes:
■ Analytes:
Coproporphyrin I, coproporphyrin III, heptacarboxyporphyrin I, hexacarboxyporphyrin I ab,
See title
hexacarboxyporphyrin I ac, internal standard, pentacarboxyporphyrin I, uroporphyrin I
Order no.
Description
17011
ClinTest® Standard Solution, ready for use, for Porphyrins
Quantity
Order no.
Description
28014
ClinTest Test Solution, lyophilised, for Vitamin C
®
Quantity
5 x 1 ml
1 x 5 ml
25-OH Vitamin D2 / D3
Serotonin
■ Analytes:
■ Analytes:
Internal standard, 25-hydroxy vitamin D2, 25-hydroxy vitamin D3
Internal standard, serotonin
Order no.
Description
6711
ClinTest® Standard Solution, lyophilised, for Serotonin
Quantity
Order no.
Description
35014
ClinTest® Test Solution, lyophilised, for 25-hydroxy Vitamin D2 / D3
Quantity
2 x 2 ml
5 x 2 ml
■ Analytes:
■ Analytes:
Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), internal standard,
Internal standard, vitamin A, vitamin E
Order no.
Description
22011
ClinTest® Standard Solution, ready for use, for Vitamin A and E
ClinTest®
VMA , HVA, and 5-HIAA
Vitamin A and E
vanillylmandelic acid (VMA)
Quantity
1 x 3 ml
Order no.
Description
3011
ClinTest® Standard Solution, lyophilised, for VMA/HVA/5-HIAA
Quantity
5 x 1 ml
Vitamin B1
■ Analytes:
Thiamine, thiaminemonophosphate (TMP), thiaminepyrophosphate (TPP)
Order no.
Description
24014
ClinTest® Test Solution, ready for use, for Vitamin B1
Quantity
1 x 3 ml
Vitamin B2
■ Analytes:
Flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN), riboflavin
Order no.
Description
25014
ClinTest® Test Solution, lyophilised, for Vitamin B2
Quantity
5 x 2 ml
Vitamin B6
■ Analytes:
Pyridoxal, Pyridoxal-5-phosphate
150
Order no.
Description
26011
ClinTest Standard Solution, ready for use, for Vitamin B6
®
Quantity
1 x 3 ml
151
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Quality Assurance
ClinCal® Calibrators
ClinCal®
Analyte Survey . . . . . . . . . . . . . . . . . . 154 - 167
Product Survey
Urine Calibrators . . . . . . . . . . . . . . . . . 168 - 170
Plasma Calibrators . . . . . . . . . . . . . . . . 170 - 172
Serum Calibrators . . . . . . . . . . . . . . . . 172 - 176
Whole Blood Calibrators . . . . . . . . . . . 176 - 177
153
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Analyte
(alphabetical)
5-ALA (5-Aminolevulinic acid)
Matrix
Urine
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
●
●
Order No.
Page
Analyte
(alphabetical)
Beryllium
Matrix
Urine
Plasma Serum
ClinCal® Calibrator
Order No.
Page
ClinCal® Trace Elements
9988
9985
9982
169
172
175
ClinCal® Trace Elements
9985
9982
172
175
ClinCal® Phenolic Compounds
9925
169
MS6013
174
Whole
● = available
Blood
❍ = in preparation
ClinCal® 5-ALA, PBG
ClinCal® Porphyrins
17213
17013
168
169
ClinCal® Amino Acids
10213
170
MS6013
174
9988
9985
9982
169
172
175
Bisphenol A
Bromazepam
●
ClinCal® Benzodiazepines
10213
170
Bromide
●
ClinCal® Antiepileptics
15013
173
●
ClinCal® Psychoactive Drugs TDM6
9717
175
ClinCal® Occupational Medicine
9922
169
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® Antiasthmatics
12013
170
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
ClinCal® β-Carotene
30013
171
MS6013
174
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® Psychoactive Drugs TDM1
ClinCal® Psychoactive Drugs TDM6
9702
9717
175
175
ClinCal® Amino Acids
10213
170
●
●
●
Alanine
●
Bismuth
Alprazolam
Aluminium
ClinCal® Benzodiazepines
●
ClinCal® Trace Elements
●
●
●
α-Aminoabutyric acid
ClinCal® Amino Acids
●
●
●
●
7-Aminoclonazepam
●
ClinCal® Benzodiazepines
MS6013
174
Bupropion
7-Aminoflunitrazepam
●
ClinCal® Benzodiazepines
MS6013
174
Butoxy acetic acid
●
17213
17013
168
169
Cadmium
●
MS6013
174
5-Aminolevulinic acid (5-ALA)
ClinCal® 5-ALA, PBG
ClinCal® Porphyrins
●
●
●
●
7-Aminonitrazepam
●
ClinCal® Benzodiazepines
Amiodarone
●
ClinCal® Amiodarone
9909
20013
172
172
●
●
Caffeine
●
Carbamazepine
Amisulpride
●
ClinCal® Psychoactive Drugs TDM2
9705
175
Amitriptyline
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
Carbamazepine-epoxide
●
●
ClinCal® Antiretrovirals
MS4013
173
β-Carotene
9988
9985
9982
169
172
175
Chlordiazepoxide
Amprenavir
Antimony
ClinCal® Trace Elements
●
●
●
●
●
●
●
Chromium
●
ClinCal® Benzodiazepines
●
●
●
Arginine
●
ClinCal® Amino Acids
10213
170
ClinCal® Psychoactive Drugs TDM1
ClinCal® Psychoactive Drugs TDM6
9702
9717
175
175
●
●
Aripiprazole
●
●
Citalopram
●
●
Arsenic
ClinCal® Trace Elements
●
●
●
●
Ascorbic acid (Vitamin C)
●
ClinCal® Vitamin C
9988
9985
9982
9943
169
172
175
177
28013
176
Asparagine
●
ClinCal® Amino Acids
10213
170
Aspartic acid
●
ClinCal® Amino Acids
10213
170
MS4013
173
9982
175
Citrulline
●
Clobazam
●
ClinCal® Benzodiazepines
MS6013
174
Clomipramine
●
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
●
ClinCal® Benzodiazepines
MS6013
174
ClinCal® Atypical Neuroleptics
ClinCal® Psychoactive Drugs TDM3
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
40013
9708
9711
MS9113
170
175
175
175
Clonazepam
Clozapine
Atazanavir
●
ClinCal® Antiretrovirals
Barium
●
ClinCal® Trace Elements
●
●
●
154
●
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
155
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 156
Analyte
(alphabetical)
Cobalt
Matrix
Urine
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Trace Elements
●
●
●
●
Coenzyme Q10 (Ubiquinone)
ClinCal® Coenzyme Q10
●
Order No.
Page
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Trace Elements
●
●
●
●
Coproporphyrin I
ClinCal® Porphyrins
●
Coproporphyrin III
●
ClinCal® Porphyrins
Cotinine
●
ClinCal® Nicotine and Metabolites
o-Cresol
●
●
ClinCal® Benzodiazepines
Diphenylhydantoin (Phenytoin)
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
31013
171
Dopamine
ClinCal® Catecholamines
2013
2113
1013
168
168
171
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
●
ClinCal® Psychoactive Drugs TDM3
ClinCal® Psychoactive Drugs TDM6
9708
9717
175
175
●
ClinCal® Antiretrovirals
MS4013
173
ClinCal® Catecholamines
2013
2113
1013
168
168
171
9705
175
MS6013
174
9988
9985
9982
9943
169
172
175
177
17013
169
17013
169
MS3013
169
ClinCal® Phenolic Compounds
9925
169
ClinCal® Immunosuppressants
5013
9028
9033
9933
177
177
177
177
●
●
MS4013
173
●
Doxepin
●
●
Duloxetine
●
●
●
●
●
●
●
Darunavir
●
ClinCal® Antiretrovirals
Escitalopram
●
ClinCal® Psychoactive Drugs TDM2
Estazolam
●
ClinCal® Benzodiazepines
Ethosuximide
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
9922
169
●
Delavirdine
●
ClinCal® Antiretrovirals
MS4013
173
Demoxepam
●
ClinCal® Benzodiazepines
MS6013
174
Desalkylflurazepam
●
ClinCal® Benzodiazepines
MS6013
174
Desethylamiodarone
●
ClinCal® Amiodarone
9909
20013
172
172
Ethoxy acetic acid
●
ClinCal® Occupational Medicine
Ethylglucuronide
●
ClinCal® Ethylglucuronide
MS8413
MS8713
MS8113
168
168
174
ClinCal® Ethylglucuronide
MS8413
MS8713
MS8113
168
168
174
ClinCal® Antiretrovirals
MS4013
173
ClinCal® Immunosuppressants
5013
9028
9033
9933
177
177
177
177
ClinCal® Vitamin B1, B2 and B6
24513
177
15213
MS9213
14113
173
173
173
24513
177
●
●
●
Ethylsulfate
●
●
Desipramine
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
●
ClinCal® Atypical Neuroleptics
ClinCal® Psychoactive Drugs TDM3
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
40013
9708
9711
MS9113
170
175
175
175
Desmethylfluoxetine
●
ClinCal® Psychoactive Drugs TDM6
9717
175
N-Desmethylmethsuximide (NDMS)
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 4
15013
14113
173
173
ClinCal® Atypical Neuroleptics
40013
170
ClinCal® Psychoactive Drugs TDM1
ClinCal® Psychoactive Drugs TDM2
ClinCal® Psychoactive Drugs TDM6
9702
9705
9717
175
175
175
●
●
●
Etravirine
Desmethylclozapine
(Norclozapine)
●
●
●
●
Everolimus
●
●
●
●
●
FAD (Flavin adenine dinucleotide,
Vitamin B2)
Felbamate
Desmethylolanzapine
●
●
ClinCal® Antiepileptics 2
●
●
ClinCal® Antiepileptics 4
●
O-Desmethylvenlafaxine
●
●
●
156
174
Diazepam
Epinephrine
●
MS6013
169
172
175
177
Efavirenz
Cyclosporine A
Page
9988
9985
9982
9943
●
Copper
Order No.
Flavin adenine dinucleotide (FAD,
Vitamin B2)
●
ClinCal® Vitamin B1, B2 and B6
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
157
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 158
Analyte
(alphabetical)
Matrix
Urine
Fluconazole
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Antimycotics
●
Order No.
Page
Analyte
(alphabetical)
9939
170
Matrix
Urine
Homocysteine
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Homocysteine
●
●
Flunitrazepam
Fluoride
ClinCal® Benzodiazepines
●
ClinCal® Trace Elements
●
●
●
Fluoxetine
●
ClinCal® Psychoactive Drugs TDM6
Flurazepam
●
ClinCal® Benzodiazepines
●
ClinCal® Psychoactive Drugs TDM6
Gabapentine
●
ClinCal® Antiepileptics 2
169
172
175
Homovanillic acid (HVA)
●
ClinCal® VMA, HVA, 5-HIAA
3013
170
HVA (Homovanillic acid)
●
ClinCal® VMA, HVA, 5-HIAA
3013
170
9717
175
α-Hydroxyalprazolam
●
ClinCal® Benzodiazepines
MS6013
174
MS6013
174
10-Hydroxy-Carbamazepine
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 2
ClinCal® Antiepileptics 3
ClinCal® Psychoactive Drugs TDM1
15013
15213
MS9213
14013
9702
173
173
173
173
175
MS3013
169
9717
175
15213
MS9213
173
173
●
●
●
ClinCal® Nicotine and Metabolites
5-Hydroxyindoleacetic acid
(5-HIAA)
●
ClinCal® VMA, HVA, 5-HIAA
3013
170
170
33013
xxx
Hydroxy-Itraconazole
ClinCal® Antimycotics
9939
170
ClinCal® Amino Acids
10213
170
α-Hydroxymidazolam
MS6013
174
ClinCal® Trace Elements
9985
9982
172
175
Hydroxyproline
ClinCal® Psychoactive Drugs TDM3
9708
175
1-Hydroxypyrene
ClinCal® Hemoglobin A1c (HbA1c)
11011
148, 176
ClinCal® Amino Acids
10213
170
Glutamine
●
ClinCal® Amino Acids
10213
ClinCal® Glutathione
Glycine
●
Gold
●
●
Haloperidol
●
Hb A1c (Hemoglobin A1c)
●
●
3ʼ-Hydroxycotinine
●
❍
Hb A2 (Hemoglobin A2)
●
ClinCal® Hemoglobin F / A2
13113
177
Hb F (Hemoglobin F)
●
ClinCal® Hemoglobin F / A2
13113
177
Hemoglobin A1c (Hb A1c)
●
ClinCal® Hemoglobin A1c (HbA1c)
11011
148, 176
Hemoglobin A2 (Hb A2)
●
ClinCal® Hemoglobin F / A2
13113
177
●
●
ClinCal® Benzodiazepines
●
ClinCal® Amino Acids
ClinCal® Hydroxyproline
10213
16013
170
168
●
ClinCal® Phenolic Compounds
9925
169
●
ClinCal® Psychoactive Drugs TDM3
ClinCal® Risperidone, Paliperidone
9708
40113
175
170
α-Hydroxytriazolam
●
ClinCal® Benzodiazepines
MS6013
174
25-Hydroxy-Vitamin D2
●
ClinCal® 25-OH Vitamins D2 / D3
35013
MS7013
176
176
ClinCal® 25-OH Vitamins D2 / D3
35013
MS7013
176
176
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
●
ClinCal® Antiretrovirals
MS4013
173
ClinCal® Trace Elements
9988
9985
169
172
ClinCal® Trace Elements
9988
9982
169
175
ClinCal® Amino Acids
10213
170
●
9-Hydroxy-Risperidone
(Paliperidone)
●
●
25-Hydroxy-Vitamin D3
●
●
Hemoglobin F (Hb F)
●
ClinCal® Hemoglobin F / A2
13113
177
Imipramine
Heptacarboxyporphyrin I
●
ClinCal® Porphyrins
17013
169
Hexacarboxyporphyrin lac, lab
●
ClinCal® Porphyrins
17013
169
Indinavir
5-HIAA
(5-Hydroxyindoleacetic acid)
●
ClinCal® VMA, HVA, 5-HIAA
3013
170
Iodide
Hippuric acid
●
●
●
●
ClinCal® Occupational Medicine
9922
169
Iron
●
●
Histidine
●
ClinCal® Amino Acids
10213
170
Isoleucine
158
171
174
177
9988
9985
9982
Glutamic Acid
Glutathione
23013
MS2013
MS2113
174
●
●
Page
MS6013
●
Fluvoxamine
Order No.
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
●
159
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 160
Analyte
(alphabetical)
Matrix
Urine
Itraconazole
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Antimycotics
●
Keppra® (Levetiracetam)
ClinCal® Antiepileptics 2
●
●
●
ClinCal® Levetiracetam
●
ClinCal® Antiepileptics 2
Order No.
Page
Analyte
(alphabetical)
9939
170
Medazepam
15213
MS9213
15513
173
173
174
Mercury
15213
MS9213
14113
173
173
173
15213
MS9213
14013
15113
9702
173
173
173
171
175
Matrix
Urine
Plasma Serum
ClinCal® Calibrator
Order No.
Page
MS6013
174
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® Metanephrines
4013
MS11013
168
xxx
ClinCal® Amino Acids
10213
170
ClinCal® Occupational Medicine
9925
169
4013
MS11013
168
xxx
Whole
● = available
Blood
❍ = in preparation
ClinCal® Benzodiazepines
●
●
●
●
●
Lacosamide
●
Lamotrigine
●
ClinCal® Antiepileptics 4
●
ClinCal® Antiepileptics 2
●
ClinCal® Antiepileptics 3
ClinCal® Lamotrigine and Sulthiame
ClinCal® Psychoactive Drugs TDM1
●
●
●
Metanephrine
●
❍
Methionine
●
Methoxy acetic acid
●
3-Methoxytyramine
●
ClinCal® Metanephrines
❍
Lead
ClinCal® Trace Elements
●
●
Leucine
ClinCal® Amino Acids
●
Levetiracetam (Keppra®)
ClinCal® Antiepileptics 2
●
●
ClinCal® Levetiracetam
●
Lithium
ClinCal® Trace Elements
●
●
9988
9943
169
177
Methylenedianiline
●
ClinCal® Occupational Medicine
9925
169
10213
170
N-Methylformamide
●
ClinCal® Occupational Medicine
9922
169
15213
MS9213
15513
173
173
174
m/p-Methyl-hippuric acid
●
ClinCal® Occupational Medicine
9922
169
o-Methyl-hippuric acid
●
ClinCal® Occupational Medicine
9922
169
9985
9982
172
175
1-Methyl-histidine
●
ClinCal® Amino Acids
10213
170
3-Methyl-histidine
●
ClinCal® Amino Acids
10213
170
MS5013
174
9717
175
MS6013
174
Lopinavir
●
ClinCal® Antiretrovirals
MS4013
173
Lorazepam
●
ClinCal® Benzodiazepines
MS6013
174
Lormetazepam
●
ClinCal® Benzodiazepines
MS6013
174
ClinCal® Amino Acids
10213
170
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® Malondialdehyde
32013
171
Lysine
Magnesium
●
●
●
●
●
Methylmalonic Acid
●
ClinCal® Methylmalonic Acid
Mianserin
●
ClinCal® Psychoactive Drugs TDM6
Midazolam
●
ClinCal® Benzodiazepines
Mirtazapine
●
ClinCal® Psychoactive Drugs TDM2
ClinCal® Psychoactive Drugs TDM6
9705
9717
175
175
ClinCal® Trace Elements
9988
9985
9982
169
172
175
ClinCal® Occupational Medicine
9922
169
ClinCal® Mycophenolic Acid
9904
29013
172
172
●
Molybdenum
●
●
●
Malondialdehyde
●
t,t-Muconic acid
Mandelic acid
●
ClinCal® Occupational Medicine
9922
169
Manganese
●
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
9711
MS9113
175
175
●
Mycophenolic Acid
●
●
●
Maprotiline
●
●
Maraviroc
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
ClinCal® Antiretrovirals
MS4013
●
1-Naphtol
●
ClinCal® Phenolic Compounds
9925
169
2-Naphtol
●
ClinCal® Phenolic Compounds
9925
169
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 4
15013
14113
173
173
●
ClinCal® Antiretrovirals
MS4013
173
NDMS (N-Desmethylmethsuximide)
●
173
Nelfinavir
160
●
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
161
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 162
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Nevirapine
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Antiretrovirals
●
Order No.
Page
Analyte
(alphabetical)
MS4013
173
Palladium
Matrix
Order No.
Page
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® Psychoactive Drugs TDM6
9717
175
●
ClinCal® 5-ALA, PBG
ClinCal® Porphyrins
17213
17013
168
169
●
ClinCal® Phenolic Compounds
9925
169
ClinCal® Antiepileptics
15013
173
Urine
Plasma Serum
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
●
●
Nickel
ClinCal® Trace Elements
●
●
●
●
Nicotine
ClinCal® Nicotine and Metabolites
●
9988
9985
9982
9943
169
172
175
177
Paroxetine
MS3013
169
PBG (Porphobilinogen)
Nitrazepam
●
ClinCal® Benzodiazepines
MS6013
174
Norclobazam
●
ClinCal® Benzodiazepines
MS6013
174
Norclomipramine
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
●
ClinCal® Atypical Neuroleptics
ClinCal® Psychoactive Drugs TDM3
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
40013
9708
9711
MS9113
170
175
175
175
Nordiazepam
●
ClinCal® Benzodiazepines
MS6013
174
Nordoxepin
●
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
2013
2113
1013
168
168
171
ClinCal® Benzodiazepines
MS6013
174
ClinCal® Metanephrines
4013
MS11013
168
xxx
●
●
PCP (Pentachlorophenol)
●
●
PEMA (Phenylethyl-malonamide)
●
Norclozapine (Desmethylclozapine)
●
●
●
●
Pentacarboxyporphyrin I
●
ClinCal® Porphyrins
17013
169
Pentachlorophenol (PCP)
●
ClinCal® Phenolic Compounds
9925
169
Perampanel
●
ClinCal® Antiepileptics 2
15213
173
Perazine
●
ClinCal® Psychoactive Drugs TDM1
9702
175
Phenobarbital
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
ClinCal® Phenolic Compounds
9925
169
ClinCal® Amino Acids
10213
170
ClinCal® Antiepileptics
15013
173
●
Phenol
Norepinephrine
ClinCal® Catecholamines
●
●
●
●
●
Phenylalanine
●
Phenylethyl-malonamide (PEMA)
Norflunitrazepam
Normetanephrine
●
●
❍
Nortriptyline
Olanzapine
Phenylglyoxylic acid
●
ClinCal® Occupational Medicine
9922
169
S-Phenylmercapturic acid
●
ClinCal® Occupational Medicine
9922
169
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
ClinCal® Amino Acids
10213
170
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
ClinCal® 5-ALA, PBG
ClinCal® Porphyrins
17213
17013
168
169
ClinCal® Antimycotics
9939
170
ClinCal® Trace Elements
9943
177
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
9711
MS9113
175
175
Phenytoin (Diphenylhydantoin)
●
ClinCal® Atypical Neuroleptics
ClinCal® Psychoactive Drugs TDM3
40013
9708
170
175
Phosphoserine
●
ClinCal® Amino Acids
10213
170
●
●
●
●
●
Platinum
Ornithine
●
●
●
●
●
Oxazepam
●
ClinCal® Benzodiazepines
MS6013
174
Oxcarbazepine
●
ClinCal® Antiepileptics
ClinCal® Antiepileptics 2
15013
15213
MS9213
14013
173
173
173
173
Porphobilinogen (PBG)
9708
40113
175
170
Potassium
●
●
Paliperidone
(9-Hydroxy-Risperidone)
162
●
●
ClinCal® Antiepileptics 3
●
ClinCal® Psychoactive Drugs TDM3
ClinCal® Risperidone, Paliperidone
●
●
●
Posaconazole
●
●
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
163
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 164
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Prazepam
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Benzodiazepines
●
Order No.
Page
Analyte
(alphabetical)
MS6013
174
Matrix
Urine
Silver
Plasma Serum
ClinCal® Calibrator
Order No.
Page
ClinCal® Trace Elements
9985
9982
9943
172
175
177
ClinCal® Immunosuppressants
5013
9028
9033
9933
177
177
177
177
ClinCal® Antiepileptics 2
15213
MS9213
173
173
ClinCal® Antiepileptics 2
15213
MS9213
14013
15113
173
173
173
171
ClinCal® Immunosuppressants
5013
9028
9033
9933
177
177
177
177
ClinCal® Amino Acids
10213
170
Whole
● = available
Blood
❍ = in preparation
●
●
Pregabaline
ClinCal® Antiepileptics 2
15213
MS9213
173
173
ClinCal® Antiepileptics
ClinCal® Antiepileptics 3
15013
14013
173
173
ClinCal® Amino Acids
10213
170
●
ClinCal® Vitamin B1, B2 and B6
ClinCal® Vitamin B6
24513
26013
177
176
●
ClinCal® Vitamin B1, B2 and B6
ClinCal® Vitamin B6
24513
26013
177
176
●
●
●
Sirolimus
Primidone
●
●
●
●
●
●
Proline
●
Stiripentol
Pyridoxal (Vitamin B6)
●
●
●
Sulthiame
Pyridoxal-5-phosphate
(Vitamin B6)
●
●
●
ClinCal® Antiepileptics 3
ClinCal® Lamotrigine and Sulthiame
●
●
Quetiapine
●
ClinCal® Atypical Neuroleptics
ClinCal® Psychoactive Drugs TDM1
ClinCal® Psychoactive Drugs TDM2
ClinCal® Psychoactive Drugs TDM3
Raltegravir
●
ClinCal® Antiretrovirals
MS4013
173
Retigabine
●
ClinCal® Antiepileptics 2
15213
MS9213
173
173
Temazepam
●
ClinCal® Benzodiazepines
MS6013
174
●
ClinCal® Benzodiazepines
MS6013
174
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
●
●
●
40013
9702
9705
9708
170
175
175
175
Tacrolimus
●
●
●
●
Taurine
●
Retinol, all-trans (Vitamin A)
Risperidone
●
ClinCal® Vitamin A and E
22013
176
Tetrazepam
●
ClinCal® Psychoactive Drugs TDM3
ClinCal® Risperidone, Paliperidone
9708
40113
175
170
Thallium
●
●
●
●
●
Ritonavir
●
ClinCal® Antiretrovirals
MS4013
173
Rufinamide
●
ClinCal® Antiepileptics 2
173
173
173
Theobromine
●
ClinCal® Antiasthmatics
12013
170
Theophylline
●
ClinCal® Antiasthmatics
12013
170
Thiaminepyrophosphate (TPP,
Vitamin B1)
ClinCal® Vitamin B1, B2 and B6
24513
177
ClinCal® Amino Acids
10213
170
ClinCal® Antiepileptics 2
15213
MS9213
173
173
ClinCal® Trace Elements
9988
9985
9982
169
172
175
MS4013
173
22013
176
●
ClinCal® Antiepileptics 4
15213
MS9213
14113
●
ClinCal® Antiretrovirals
MS4013
173
9988
9985
9982
9943
169
172
175
177
●
Saquinavir
Selenium
ClinCal® Trace Elements
●
●
●
●
●
●
Threonine
●
Tiagabine
●
●
Serine
●
ClinCal® Amino Acids
10213
170
ClinCal® Serotonin
7013
6013
169
172
Tin
Serotonin
●
●
164
●
●
●
Sertindole
●
ClinCal® Psychoactive Drugs TDM6
9717
175
Tipranavir
●
ClinCal® Antiretrovirals
Sertraline
●
ClinCal® Psychoactive Drugs TDM6
9717
175
α-Tocopherol (Vitamin E)
●
ClinCal® Vitamin A and E
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
165
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 166
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Topiramate
ClinCal® Calibrator
Whole
● = available
Blood
❍ = in preparation
ClinCal® Antiepileptics 2
●
●
TPP (Thiaminepyrophosphate,
Vitamin B1)
●
ClinCal® Vitamin B1, B2 and B6
Order No.
Page
Analyte
(alphabetical)
15213
MS9213
173
173
Vitamin D2
24513
177
Vitamin D3
Urine
Plasma Serum
ClinCal® Calibrator
Order No.
Page
ClinCal® 25-OH Vitamins D2 / D3
35013
MS7013
176
176
ClinCal® 25-OH Vitamins D2 / D3
35013
MS7013
176
176
ClinCal® Vitamin A and E
22013
176
ClinCal® VMA, HVA, 5-HIAA
3013
170
ClinCal® Antimycotics
9939
170
MS6013
174
ClinCal® Trace Elements
9988
9985
9982
9943
169
172
175
177
9708
175
Whole
● = available
Blood
❍ = in preparation
●
●
●
●
Trazodone
●
ClinCal® Benzodiazepines
MS6013
174
Vitamin E
Triazolam
●
ClinCal® Benzodiazepines
MS6013
174
VMA (Vanillylmandelic acid)
9922
169
Voriconazole
9711
MS9113
175
175
Zaleplon
Trichloroacetic acid
Matrix
ClinCal® Occupational Medicine
●
Trimipramine
ClinCal® Psychoactive Drugs TDM4
ClinCal® Tricyclic Antidepressants
●
●
Zinc
●
●
●
ClinCal® Benzodiazepines
●
●
Tryptophane
●
ClinCal® Amino Acids
10213
170
Tyrosine
●
ClinCal® Amino Acids
10213
170
Ubiquinone (Coenzyme Q10)
●
ClinCal® Coenzyme Q10
31013
171
Ziprasidone
●
ClinCal® Psychoactive Drugs TDM3
Urea
●
ClinCal® Amino Acids
10213
170
Zolpidem
●
ClinCal® Benzodiazepines
MS6013
174
ClinCal® Porphyrins
17013
169
Zonisamide
●
ClinCal® Antiepileptics 2
173
173
173
174
●
●
Uroporphyrin I
●
●
●
ClinCal® Antiepileptics 4
15213
MS9213
14113
●
ClinCal® Benzodiazepines
MS6013
●
Valine
Valproic acid
Vanadium
ClinCal® Amino Acids
10213
170
ClinCal® Antiepileptics
15013
173
ClinCal® Trace Elements
9988
9985
9982
169
172
175
ClinCal® VMA, HVA, 5-HIAA
3013
170
●
ClinCal® Psychoactive Drugs TDM1
ClinCal® Psychoactive Drugs TDM2
ClinCal® Psychoactive Drugs TDM6
9702
9705
9717
175
175
175
●
ClinCal® Antiepileptics 2
15213
MS9213
173
173
ClinCal® Vitamin A and E
22013
176
●
●
●
●
●
Vanillylmandelic acid (VMA)
Venlafaxine
●
●
●
Vigabatrine
●
Vitamin A
●
Vitamin B1
●
ClinCal® Vitamin B1, B2 and B6
24513
177
Vitamin B2
●
ClinCal® Vitamin B1, B2 and B6
24513
177
●
●
ClinCal® Vitamin B1, B2 and B6
ClinCal® Vitamin B6
24513
26013
177
176
●
ClinCal® Vitamin C
28013
176
Vitamin B6
Vitamin C
166
Zopiclone
ClinCal®
With ClinCal® Calibrator Materials the following analytes
are available:
Analyte Survey
167
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 168
Product Survey
The analytes listed in the Analyte Survey (see pages 154 - 167) are included in
the following ClinCal® Urine, Plasma, Serum, and Whole Blood Calibrators:
Nicotine and Metabolites (Calibrator Set)
■ Analytes:
Cotinine, 3ʼ-hydroxycotinine, nicotine
Order no.
Description
MS3013
ClinCal® Urine Calibrator Set, lyophil., for Nicotine and Metabolites
ClinCal® Urine Calibrators, Lyophilised:
Quantity
7 x 1 x 3 ml
(Level 0 - 6)
5-ALA, PBG
Porphyrins
■ Analytes:
■ Analytes:
5-Aminolevulinic acid (5-ALA), porphobilinogen (PBG)
5-Aminolevulinic acid (5-ALA), coproporphyrin I, coproporphyrin III,
Order no.
Description
17213
ClinCal® Urine Calibrator, lyophil., for 5-ALA, PBG
Quantity
5 x 5 ml
heptacarboxyporphyrin I, hexacarboxyporphyrin Iac + Iab,
pentacarboxyporphyrin I, porphobilinogen (PBG), uroporphyrin I
Order no.
Description
17013
ClinCal® Urine Calibrator, lyophil., for Porphyrins
Quantity
5 x 5 ml
Catecholamines
■ Analytes:
Serotonin
Description
2013
ClinCal Urine Calibrator, lyophil., for Catecholamines
5 x 8 ml
See title
2113
ClinCal® Urine Calibrator, lyophil., for Catecholamines (FD)
5 x 5 ml
Order no.
Description
7013
ClinCal Urine Calibrator, lyophil., for Serotonin
®
Quantity
■ Analytes:
Order no.
Quantity
5 x 8 ml
®
ClinCal®
Dopamine, epinephrine, norepinephrine
Ethylglucuronide (Calibrator Sets)
■ Analytes:
Parameters for Occupational Medicine
■ Analytes:
Ethylglucuronide, ethylsulfate
Order no.
Description
MS8413
ClinCal® Urine Calibrator Set, lyophil., for Ethylglucuronide
Quantity
4 x 1 x 1 ml
(Level 0 - 3)
MS8713
ClinCal Urine Calibrator Set, lyophil., for Ethylglucuronide
®
methylenedianiline, N-methyl-formamide, m/p-methyl-hippuric acid, o-methyl-hippuric acid,
t,t-muconic acid, phenylglyoxylic acid, S-phenylmercapturic acid, trichloroacetic acid
7 x 1 x 1 ml
(Level 0 - 6)
Order no.
Description
9922
ClinCal® Urine Calibrator, lyophil., for Occupational Medicine
Hydroxyproline
Phenolic Compounds
■ Analytes:
■ Analytes:
See title
Quantity
5 x 5 ml
Bisphenol A, o-cresol, 1-hydroxypyrene, 1-naphtol, 2-naphtol, pentachlorophenol, phenol
Order no.
Description
16013
ClinCal Urine Calibrator, lyophil., for Hydroxyproline
®
Quantity
5 x 8 ml
Metanephrines
168
Butoxy acetic acid, ethoxy acetic acid, hippuric acid, mandelic acid, methoxy acetic acid,
Order no.
Description
9925
ClinCal Urine Calibrator, lyophil., for Phenolic Compounds
®
■ Analytes:
Metanephrine, 3-methoxytyramine, normetanephrine
Al, As, Be, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Iodide, Mg, Mn, Mo, Ni, Pb, Pd, Pt, Sb,
Description
4013
ClinCal® Urine Calibrator, lyophil., for Metanephrines
5 x 5 ml
Trace Elements
■ Analytes:
Order no.
Quantity
Quantity
5 x 8 ml
Se, Sn, Tl, V, Zn
Order no.
Description
Quantity
9988
ClinCal Urine Calibrator, lyophil., for Trace Elements
5 x 10 ml
®
169
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Product Survey
VMA, HVA, 5-HIAA
β-Carotene
■ Analytes:
■ Analytes:
Vanillylmandelic acid (VMA), homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA)
Order no.
Description
3013
ClinCal® Urine Calibrator, lyophil., for VMA, HVA, 5-HIAA
See title
Quantity
5 x 5 ml
Order no.
Description
30013
ClinCal Plasma Calibrator, lyophil., for β-Carotene
®
Quantity
5 x 0.5 ml
Catecholamines
ClinCal® Plasma Calibrators, Lyophilised:
■ Analytes:
Dopamine, epinephrine, norepinephrine
Amino Acids (by Amino Acid Analyser)
Order no.
Description
1013
ClinCal® Plasma Calibrator, lyophil., for Catecholamines
Quantity
5 x 5 ml
■ Analytes:
Alanine, α-aminobutyric acid, arginine, asparagine, aspartic acid, citrulline, glutamic acid,
glutamine, glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine,
Coenzyme Q10
1-methyl-histidine, 3-methyl-histidine, ornithine, phenylalanine, phosphoserine, proline, serine,
■ Analytes:
taurine, threonine, tryptophane, tyrosine, urea, valine
See title
Description
10213
ClinCal® Plasma Calibrator, lyophil., for Amino Acids (by Amino Acid Analyser)
Quantity
5 x 3 ml
Order no.
Description
31013
ClinCal Plasma Calibrator, lyophil., for Coenzyme Q10
®
Antiasthmatics
Homocysteine
■ Analytes:
■ Analytes:
Caffeine, theobromine, theophylline
Order no.
Description
12013
ClinCal® Plasma Calibrator, lyophil., for Antiasthmatics
1 x 3 ml
Order no.
Description
23013
ClinCal® Plasma Calibrator, lyophil., for Homocysteine
■ Analytes:
Fluconazole, itraconazole, hydroxy-itraconazole, posaconazole, voriconazole
Lamotrigine, sulthiame
9939
ClinCal Plasma Calibrator Set, lyophil., for Antimycotics
®
Quantity
1 x 3 ml
Lamotrigine and Sulthiame
■ Analytes:
Description
5 x 2 ml
See title
Quantity
Antimycotics (Calibrator Set)
Order no.
Quantity
ClinCal®
Order no.
Quantity
4 x 1 x 1 ml
Order no.
Description
15113
ClinCal® Plasma Calibrator, lyophil., for Lamotrigine and Sulthiame
Quantity
1 x 3 ml
(Level 0 - 3)
Malondialdehyde
Atypical Neuroleptics
■ Analytes:
■ Analytes:
See title
Clozapine, desmethylclozapine, desmethylolanzapine, olanzapine, quetiapine
Order no.
Description
40013
ClinCal® Plasma Calibrator, lyophil., for Atypical Neuroleptics
Quantity
Order no.
Description
32013
ClinCal Plasma Calibrator, lyophil., for Malondialdehyde
®
Quantity
5 x 0.5 ml
5 x 3 ml
■ Analytes:
Paliperidone (9-OH-risperidone), risperidone
170
Order no.
Description
40113
ClinCal Plasma Calibrator, lyophil., for Risperidone, Paliperidone
®
Quantity
5 x 5 ml
171
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Product Survey
Mycophenolic Acid (Single Point / Calibrator Set)
Antiepileptics (Single Point / Calibrator Set)
■ Analytes:
■ Analytes:
See title
Bromide, carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide,
Order no.
Description
29013
ClinCal® Plasma Calibrator, lyophil., for Mycophenolic Acid
Quantity
1 x 3 ml
(single point)
9904
ClinCal® Plasma Calibrator Set, lyophil., for Mycophenolic Acid
4 x 1 x 1 ml
ethosuximide, 10-hydroxy-carbamazepine, oxcarbazepine, PEMA, phenobarbital,
phenytoin, primidone, valproic acid
Order no.
Description
15013
ClinCal® Serum Calibrator, lyophil., Antiepileptics
Quantity
1 x 3 ml
(Level 0 - 3)
■ Analytes:
Felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine,
Serotonin
levetiracetam, oxcarbazepine, perampanel, pregabaline, retigabine, rufinamide,
■ Analytes:
stiripentol, sulthiame, tiagabine, topiramate, vigabatrine, zonisamide
See title
Order no.
Description
6013
ClinCal® Plasma Calibrator, lyophil., for Serotonin
Quantity
Order no.
Description
15213
ClinCal® Serum Calibrator, lyophil., Antiepileptics 2
Quantity
1 x 2 ml
1 x 5 ml
■ Analytes:
10-OH-Carbamazepine, felbamate, gabapentine, lacosamide, lamotrigine,
levetiracetam, oxcarbazepine, pregabaline, retigabine, rufinamide, stiripentol,
■ Analytes:
sulthiame, tiagabine, topiramate, vigabatrine, zonisamide
Ag, Al, As, Au, Be, Bi, Cd, Co, Cr, Cu, Fluoride, Hg, Iodide, Li, Mg, Mn, Mo, Ni,
Order no.
Description
Pd, Pt, Sb, Se, Sn, Tl, V, Zn
MS9213
ClinCal Serum Calibrator Set, lyophil., Antiepileptics 2
Order no.
Description
9985
ClinCal® Plasma Calibrator, lyophil., for Trace Elements
Quantity
5 x 3 ml
®
Quantity
4 x 1 x 1 ml
ClinCal®
Trace Elements
(Level 0 - 3)
■ Analytes:
Carbamazepine, carbamazepine-epoxide, ethosuximide, 10-hydroxy-carbamazepine,
lamotrigine, oxcarbazepine, phenobarbital, phenytoin, primidone, sulthiame
Order no.
Description
ClinCal® Serum Calibrators, Lyophilised:
14013
ClinCal Serum Calibrator, lyophil., Antiepileptics 3
Amiodarone (Single Point / Calibrator Set)
N-Desmethylmethsuximide, felbamate, lacosamide, rufinamide, zonisamide
■ Analytes:
Order no.
Description
Amiodarone, desethylamiodarone
14113
ClinCal Serum Calibrator, lyophil., Antiepileptics 4
®
Quantity
1 x 3 ml
■ Analytes:
Order no.
Description
20013
ClinCal® Serum Calibrator, lyophil., for Amiodarone
9909
ClinCal® Serum Calibrator Set, lyophil., for Amiodarone
(Level 0 - 3)
®
Quantity
1 x 3 ml
Quantity
1 x 3 ml
4 x 1 x 2 ml
Antiretrovirals (Calibrator Set)
■ Analytes:
Amprenavir, atazanavir, darunavir, delavirdine, efavirenz, etravirine, indinavir,
lopinavir, maraviroc, nelfinavir, nevirapine, raltegravir, ritonavir, saquinavir, tipranavir
Order no.
Description
MS4013
ClinCal Serum Calibrator Set, lyophil., for Antiretrovirals
®
Quantity
7 x 1 x 0.5 ml
(Level 0 - 6)
172
173
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Product Survey
Psychoactive Drugs TDM 1 - TDM 4, TDM 6
Benzodiazepines (Calibrator Set)
■ Analytes:
■ Analytes:
Alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam,
Aripiprazole, citalopram, O-desmethylvenlafaxine, 10-hydroxy-carbamazepine,
bromazepam, chlordiazepoxide, clobazam, clonazepam, demoxepam,
lamotrigine, perazine, quetiapine, venlafaxine
desalkylflurazepam, diazepam, estazolam, flunitrazepam, flurazepam,
Order no.
Description
α-hydroxyalprazolam, α-hydroxymidazolam, α-hydroxytriazolam, lorazepam,
9702
ClinCal Serum Calibrator, lyophil., for Psychoactive Drugs TDM1
®
Quantity
5 x 5 ml
lormetazepam, medazepam, midazolam, nitrazepam, norclobazam, nordiazepam,
■ Analytes:
norflunitrazepam, oxazepam, prazepam, temazepam, tetrazepam, trazodone,
Amisulpride, O-desmethylvenlafaxine, escitalopram, mirtazapine, quetiapine, venlafaxine
triazolam, zaleplon, zolpidem, zopiclone
Order no.
Description
MS6013
ClinCal Serum Calibrator Set, lyophil., for Benzodiazepines
Quantity
4 x 1 x 1 ml
®
Order no.
Description
9705
ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM2
Quantity
5 x 5 ml
(Level 0 - 3)
■ Analytes:
Clozapine, desmethylclozapine, duloxetine, haloperidol, olanzapine, paliperidone,
Ethylglucuronide (Calibrator Set)
quetiapine, risperidone, ziprasidone
■ Analytes:
Order no.
Description
Ethylglucuronide, ethylsulfate
9708
ClinCal Serum Calibrator, lyophil., for Psychoactive Drugs TDM3
Order no.
Description
MS8113
ClinCal® Serum Calibrator Set, lyophil., for Ethylglucuronide
®
Quantity
5 x 5 ml
Quantity
4 x 1 x 1 ml
■ Analytes:
Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin,
(Level 0 - 3)
Homocysteine (Calibrator Set)
Order no.
Description
9711
ClinCal® Serum Calibrator, lyophil., for Psychoactive Drugs TDM4
ClinCal®
imipramine, maprotiline, norclomipramine, nordoxepin, nortriptyline, trimipramine
Quantity
5 x 5 ml
■ Analytes:
■ Analytes:
See title
Order no.
Description
MS2013
ClinCal® Serum Calibrator Set, lyophil., for Homocysteine
Quantity
Aripiprazole, bupropion, citalopram, desmethylfluoxetine, O-desmethylvenlafaxine,
4 x 1 x 1 ml
duloxetine, fluoxetine, fluvoxamine, mianserin, mirtazapine, paroxetine, sertindole,
sertraline, venlafaxine
(Level 0 - 3)
Order no.
Description
9717
ClinCal Serum Calibrator, lyophil., for Psychoactive Drugs TDM6
®
Quantity
5 x 5 ml
Levetiracetam (Keppra®)
■ Analytes:
Trace Elements
See title
Order no.
Description
15513
ClinCal Serum Calibrator, lyophil., for Levetiracetam (Keppra )
®
Quantity
®
1 x 3 ml
■ Analytes:
Ag, Al, As, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Li, Mg, Mo, Mn, Ni,
Pd, Pt, Sb, Se, Sn, Tl, V, Zn
Methylmalonic Acid (Calibrator Set)
Order no.
Description
9982
ClinCal Serum Calibrator, lyophil., for Trace Elements
®
Quantity
5 x 3 ml
■ Analytes:
See title
Order no.
Description
MS5013
ClinCal® Serum Calibrator Set, lyophil., for Methylmalonic Acid
(Level 0 - 3)
Quantity
4 x 1 x 2 ml
Tricyclic Antidepressants (Calibrator Set)
■ Analytes:
Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin,
imipramine, maprotiline, norclomipramine, nordoxepin, nortriptyline, trimipramine
Order no.
Description
MS9113
ClinCal Serum Calibrator Set, lyophil., for Tricyclic Antidepressants
®
Quantity
4 x 1 x 1 ml
(Level 0 - 3)
174
175
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Product Survey
Vitamins A and E
Hemoglobins F/A2
■ Analytes:
■ Analytes:
See title
Hemoglobin F, hemoglobin A2
Order no.
Description
22013
ClinCal® Serum Calibrator, lyophil., for Vitamins A and E
Quantity
1 x 3 ml
Vitamin B6
Order no.
Description
13113
ClinCal® Hemolysate Calibrator, ready for use, for Hemoglobins F / A2
Quantity
5 x 3 ml
Homocysteine (Calibrator Set, DBS)
■ Analytes:
■ Analytes:
Pyridoxal, pyridoxal-5-phosphate (PLP)
See title
Order no.
Description
26013
ClinCal Serum Calibrator, lyophil., for Vitamin B6
®
Quantity
1 x 3 ml
Order no.
Description
MS2113
ClinCal Whole Blood Calibrator Set, filter spots, for Homocysteine
®
Quantity
4 x 1 x 3 spots
(Level 0 - 3)
Vitamin C
■ Analytes:
Immunosuppressants (Single Point / Calibrator Set)
■ Analytes:
See title
Order no.
Description
28013
ClinCal® Serum Calibrator, lyophil., for Vitamin C
Quantity
5 x 0.5 ml
Cyclosporine A, everolimus, sirolimus, tacrolimus
Order no.
Description
5013
ClinCal Whole Blood Calibrator, lyophil.,
®
Quantity
5 x 2 ml
25-OH Vitamin D2 / D3 (Single Point / Calibrator Set)
9033
■ Analytes:
4 x 1 x 2 ml
for Immunosuppressants (Level 0 - 3)
25-Hydroxy-vitamin D2, 25-hydroxy-vitamin D3
Order no.
Description
35013
ClinCal® Serum Calibrator, lyophil., for 25-OH Vitamin D2 / D3
9933
5 x 2 ml
ClinCal® Serum Calibrator Set, lyophil., for 25-OH Vitamin D2 / D3
ClinCal® Whole Blood Calibrator Set, lyophil.,
7 x 1 x 2 ml
for Immunosuppressants (Level 0 - 6)
Quantity
9028
(single point)
MS7013
ClinCal® Whole Blood Calibrator Set, lyophil.,
ClinCal®
for Immunosuppressants (single point)
ClinCal® Whole Blood Calibrator, lyophil.,
2 x 2 ml
for Immunosuppressants (Level 7)
4 x 1 x 1 ml
(Level 0 - 3)
Trace Elements
■ Analytes:
Ag, As, Cd, Co, Cr, Cu, Hg, K, Mg, Mn, Ni, Pb, Pd, Pt, Se, Tl, Zn
ClinCal® Whole Blood Calibrators, Lyophilised / Ready for Use:
Order no.
Description
9943
ClinCal® Whole Blood Calibrator, lyophil., for Trace Elements
Quantity
5 x 5 ml
Hemoglobin A1c
■ Analytes:
Vitamins B1, B2, B6
■ Analytes:
See title
176
Order no.
Description
Quantity
Flavin adenine dinucleotide (FAD), pyridoxal, pyridoxal-5-phosphate (PLP),
11011
ClinTest® Reference Standard, ready for use, for HbA1c
10 x 5 ml
thiaminepyrophosphate (TPP)
Order no.
Description
24513
ClinCal® Whole Blood Calibrator, lyophil., for Vitamins B1, B2 and B6
Quantity
5 x 2 ml
177
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Quality Assurance
ClinChek® Controls
Analyte Survey . . . . . . . . . . . . . . . . . . 180 - 195
Product Survey
Urine Controls . . . . . . . . . . . . . . . . . . . 196 - 198
ClinChek®
Plasma Controls . . . . . . . . . . . . . . . . . . 198 - 201
Serum Controls . . . . . . . . . . . . . . . . . . 201 - 206
Whole Blood Controls . . . . . . . . . . . . . 206 - 207
179
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Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Acetylcarnitine
5-ALA (5-Aminolevulinic acid)
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
●
●
●
Alanine
●
●
ClinChek® Acylcarn. a. Amino Acids
Order No.
Page
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® Arsenic Species
8931
196
10182
206
Arsenobetaine
ClinChek® 5-ALA / PBG
ClinChek® Porphyrins
17280-17282
17080-17082
196
198
Ascorbic Acid (Vitamin C)
●
ClinChek® Vitamin C
28080-28082
205
Asialotransferrin
●
ClinChek® CDT
21080-21082
203
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
Asparagine
●
ClinChek® Amino Acids
10280-10282
198
8605
203
Aspartic acid
●
ClinChek® Amino Acids
10280-10282
198
MS4082
202
●
●#
ClinChek® CSF/Serum Quotients
Alprazolam
●
ClinChek® Benzodiazepines
MS6082
203
Atazanavir
●
ClinChek® Antiretrovirals
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
Barium
●
ClinChek® Trace Elements
8880-8882
205
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
ClinChek® Trace Elements
8883-8885
8880-8882
201
205
8925
198
8850-8851
203
8928
197
MS6082
203
15080-15082
202
●
●
●
Beryllium
●
●
α-Aminobutyric acid
ClinChek® Amino Acids
●
7-Aminoclonazepam
ClinChek® Benzodiazepines
●
10280-10282
198
MS6082
203
●
Bismuth
●
●
7-Aminoflunitrazepam
ClinChek® Benzodiazepines
●
MS6082
203
17280-17282
17080-17082
196
198
MS6082
203
20080-20082
201
Br2-CA [3-(2,2-Dibromovinyl)2,2-dimethylcyclopropan1-carboxylic acid])
Bisphenol A
5-Aminolevulinic acid (5-ALA)
ClinChek® 5-ALA / PBG
ClinChek® Porphyrins
●
●
ClinChek® Phenolic Compounds
●
Blank (Drugfree)
ClinChek® Drugfree
●
7-Aminonitrazepam
●
ClinChek® Benzodiazepines
Amiodarone
●
ClinChek® Amiodarone
Amisulpride
●
ClinChek® Psychoactive Drugs TDM2
8705
204
Bromazepam
●
ClinChek® Benzodiazepines
Amitriptyline
●
ClinChek® Psychoactive Drugs TDM4
8711
204
Bromide
●
ClinChek® Antiepileptics
Amprenavir
●
ClinChek® Antiretrovirals
MS4082
202
Bupropion
●
ClinChek® Psychoactive Drugs TDM6
8717
205
8847-8849
8883-8885
8880-8882
198
201
205
Butoxy acetic acid
ClinChek® Parameters for
Occupational Medicine
8922
197
ClinChek® Acylcarn. a. Amino Acids
10182
206
10182
10280-10282
206
198
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
ClinChek® Antiasthmatics
12080-12082
199
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
●
ClinChek® CDT
21080-21082
203
Antimony
ClinChek® Trace Elements
●
●
●
ClinChek® Parameters for
Environmental Medicine
●
●
Butyrylcarnitine
Arginine
●
●
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
Cadmium
●
●
●
Aripiprazole
ClinChek® Psychoactive Drugs TDM1
ClinChek® Psychoactive Drugs TDM6
●
●
Arsenic
ClinChek® Trace Elements
●
●
●
●
Arsenic III
Arsenic V
●
●
ClinChek® Arsenic Species
ClinChek® Arsenic Species
8702
8717
204
205
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
Caffeine
8931
196
Carbamazepine-epoxide
8931
●
●
Carbamazepine
●
●
●
●
196
Carbohydrate deficient
transferrin (CDT)
180
Page
Albumin
Aluminium
#
Order No.
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
Serum and CSF
181
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Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Carnitine
Whole
● = available
Blood
❍ = in preparation
●
β-Carotene
●
CDT (Carbohydrate
deficient transferrin)
●
Chlordiazepoxide
●
Chromium
ClinChek® Control
ClinChek® Acylcarn. a. Amino Acids
Order No.
Page
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
●
ClinChek® Nicotine and Metabolites
ClinChek® β-Carotene
30080-30082
200
o-Cresol
●
ClinChek® Phenolic Compounds
8925
198
ClinChek® CDT
21080-21082
203
Cyclosporine A
ClinChek® Immunosuppressants
8903
8830-8833
207
207
MS4082
202
10182
206
ClinChek® Benzodiazepines
MS6082
203
Darunavir
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
Decanoylcarnitine
ClinChek® Psychoactive Drugs TDM1
ClinChek® Psychoactive Drugs TDM6
8702
8717
204
205
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
8928
197
●
●
Citrulline
●
●
cis-Cl2-CA [cis-3(2,2-Dichlorovinyl)2,2-dimethylcyclopropan1-carboxylic acid]
●
trans-Cl2-CA [trans-3(2,2-Dichlorovinyl)2,2-dimethylcyclopropan1-carboxylic acid]
●
●
ClinChek® Parameters for
Environmental Medicine
ClinChek® Parameters for
Environmental Medicine
●
197
Clobazam
●
ClinChek® Benzodiazepines
Clomipramine
●
ClinChek® Psychoactive Drugs TDM4
Clonazepam
●
ClinChek® Benzodiazepines
●
ClinChek® Antiretrovirals
MS4082
202
Demoxepam
●
ClinChek® Benzodiazepines
MS6082
203
Desalkylflurazepam
●
ClinChek® Benzodiazepines
MS6082
203
Desethylamiodarone
●
ClinChek® Amiodarone
20080-20082
201
Desipramine
●
ClinChek® Psychoactive Drugs TDM4
8711
204
●
●
ClinChek® Atypical Neuroleptics
40080-40082
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Psychoactive Drugs TDM4
8711
199
204
204
Desmethylfluoxetine
●
ClinChek® Psychoactive Drugs TDM6
8717
205
N-Desmethylmethsuximide (NDMS)
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 4
15080-15082
14180-14182
202
202
ClinChek® Atypical Neuroleptics
40080-40082
199
●
MS6082
203
Desmethylolanzapine
8711
204
Desmethylsertraline
●
ClinChek® Psychoactive Drugs TDM6
8717
205
MS6082
203
O-Desmethylvenlafaxine
●
●
ClinChek® Psychoactive Drugs TDM1
ClinChek® Psychoactive Drugs TDM2
ClinChek® Psychoactive Drugs TDM6
8702
8705
8717
204
204
205
●
ClinChek® Benzodiazepines
MS6082
203
ClinChek® Arsenic Species
8931
196
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
●
ClinChek® CDT
21080-21082
203
10182
206
8820-8822
8809-8811
2180-2182
196
199
196
8711
204
●
●
●
●
●
Cobalt
●
ClinChek® Atypical Neuroleptics
40080-40082
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Psychoactive Drugs TDM4
8711
199
204
204
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
Dimethylarsinic Acid
ClinChek® Coenzyme Q10
31080-31082
200
Disialotransferrin
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
Dodecanoylcarnitine
●
●
●
Coenzyme Q10 (Ubiquinone)
Copper
●
●
●
●
●
Diazepam
●
Diphenylhydantoin (Phenytoin)
Dopamine
●
●
Coproporphyrin I
●
ClinChek® Porphyrins
17080-17082
198
Coproporphyrin III
●
ClinChek® Porphyrins
17080-17082
198
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Biogenic Amines
●
●
ClinChek® Catecholamines (FD)
●
Doxepin
182
ClinChek® Acylcarn. a. Amino Acids
Delavirdine
Desmethylclozapine
(Norclozapine)
8928
ClinChek® Antiretrovirals
●
●
Clozapine
197
Cotinine
●
●
MS3080-3083
206
●
Citalopram
Page
10182
●
●
Order No.
●
ClinChek® Psychoactive Drugs TDM4
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
183
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Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Duloxetine
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
●
ClinChek® Psychoactive Drugs TDM3
ClinChek® Psychoactive Drugs TDM6
●
ClinChek® Antiretrovirals
●
Efavirenz
Order No.
Page
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Biogenic Amines
●
●
ClinChek® Catecholamines (FD)
●
MS4082
202
8820-8822
8809-8811
2180-2182
196
199
196
Glutamine
8705
204
Glutarylcarnitine
●
ClinChek® Acylcarn. a. Amino Acids
MS6082
203
Glutathione
❍
●
ClinChek® Antiepileptics 2
15282
202
Glucose
●#
ClinChek® CSF/Serum Quotients
8605
203
Estazolam
●
ClinChek® Benzodiazepines
Ethosuximide
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
Glycine
ClinChek® Parameters for
Occupational Medicine
8922
197
Gold
ClinChek® Ethylglucuronide
MS8080-8083
MS8180-8182
197
203
ClinChek® Ethylglucuronide
MS8080-8083
MS8180-8182
197
203
Ethylglucuronide
●
●
Ethylsulfate
●
●
●
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
●
ClinChek® Amino Acids
10280-10282
198
10182
206
ClinChek® Glutathione
33080-33082
xxx
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
8883-8885
8880-8882
201
205
8708
204
11080-11082
206
●
●
ClinChek® Trace Elements
●
●
Haloperidol
ClinChek® Psychoactive Drugs TDM3
●
Hb A1c (Hemoglobin A1c)
●
ClinChek® Hemoglobin A1c
Hb A2 (Hemoglobin A2)
●
ClinChek® Hemoglobins F / A2
ClinChek® Hemoglobins F / A2 / S
13182
13183
207
207
●
ClinChek® Hemoglobin A1c
ClinChek® Hemoglobins F / A2
ClinChek® Hemoglobins F / A2 / S
11080-11082
13182
13183
206
207
207
Hb S (Hemoglobin S)
●
ClinChek® Hemoglobins F / A2 / S
13183
207
Hemoglobin A1c (Hb A1c)
●
ClinChek® Hemoglobin A1c
11080-11082
206
Hemoglobin A2 (Hb A2)
●
ClinChek® Hemoglobins F / A2
ClinChek® Hemoglobins F / A2 / S
13182
13183
207
207
●
ClinChek® Hemoglobin A1c
ClinChek® Hemoglobins F / A2
ClinChek® Hemoglobins F / A2 / S
11080-11082
13182
13183
206
207
207
●
Etravirine
ClinChek® Antiretrovirals
●
MS4082
202
Hb F (Hemoglobin F)
Everolimus
●
ClinChek® Immunosuppressants
8830-8833
207
FAD (Flavin adenine dinucleotide,
Vitamin B2)
●
ClinChek® Vitamins
8874-8876
207
Felbamate
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 4
●
●
Flavin adenine dinucleotide (FAD,
Vitamin B2)
●
●
●
15282
14180-14182
202
202
8874-8876
207
8839
199
ClinChek® Benzodiazepines
MS6082
203
Hemoglobin S (Hb S)
●
ClinChek® Hemoglobins F / A2 / S
13183
207
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
Hemoglobin, free
●
ClinChek® Free Hemoglobin
ClinChek® Free Hemoglobin (low)
8812-16
8912-16
206
206
8717
205
Heptacarboxyporphyrin I
●
ClinChek® Porphyrins
17080-17082
198
MS6082
203
Hexacarboxyporphyrin Iab + lac
●
ClinChek® Porphyrins
17080-17082
198
8717
205
Hexadecanoylcarnitine
●
ClinChek® Acylcarn. a. Amino Acids
10182
206
8812-8816
8912-8916
206
206
Hexanoylcarnitine
●
ClinChek® Acylcarn. a. Amino Acids
10182
206
ClinChek® Vitamins
●
Hemoglobin F (Hb F)
Fluconazole
Flunitrazepam
Fluoride
ClinChek® Antimycotics
●
●
●
●
●
Fluoxetine
●
ClinChek® Psychoactive Drugs TDM6
Flurazepam
●
ClinChek® Benzodiazepines
Fluvoxamine
●
ClinChek® Psychoactive Drugs TDM6
Free hemoglobin
●
●
ClinChek® Free Hemoglobin
ClinChek® Free Hemoglobin (low)
●
●
●
#
184
Page
●
ClinChek® Psychoactive Drugs TDM2
●
❍ = in preparation
Order No.
Gabapentine
●
Ethoxy acetic acid
● = available
Blood
204
205
Escitalopram
●
Whole
8708
8717
Glutamic acid
Epinephrine
ClinChek® Control
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
Serum and CSF
185
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Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Hexasialotransferrin
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® CDT
●
5-HIAA (5-Hydroxyindoleacetic acid)
●
ClinChek® Biogenic Amines
Hippuric acid
●
ClinChek® Parameters for
Occupational Medicine
Order No.
Analyte
Page
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
203
IgM (Immunoglobuline M)
●#
ClinChek® CSF/Serum Quotients
8605
203
8820-8822
196
Imipramine
●
ClinChek® Psychoactive Drugs TDM4
8711
204
8922
197
Immunoglobuline A (IgA)
●#
ClinChek® CSF/Serum Quotients
8605
203
Immunoglobuline G (IgG)
●#
ClinChek® CSF/Serum Quotients
8605
203
8605
203
MS4082
202
ClinChek® Trace Elements
8847-8849
8883-8885
198
201
ClinChek® Trace Elements
8847-8849
8880-8882
198
205
10280-10282
198
ClinChek® Acylcarn. a. Amino Acids
10182
206
ClinChek® Antimycotics
8839
199
ClinChek® Antiepileptics 2
ClinChek® Levetiracetam
15282
15580-15582
202
204
●
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 4
15282
14180-14182
202
202
Lactate
●#
ClinChek® CSF/Serum Quotients
8605
203
Lamotrigine
●
ClinChek® Antiepileptics 2
15282
ClinChek® Antiepileptics 3
14080-14082
ClinChek® Lamotrigine a. Sulthiame 15180-15182
ClinChek® Psychoactive Drugs TDM1
8702
202
202
200
204
ClinChek® Trace Elements
8847-8849
8840-8843
198
207
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
ClinChek® Antiepileptics 2
ClinChek® Levetiracetam
15282
15580-15582
202
204
ClinChek® Trace Elements
8883-8885
8880-8882
201
205
●
ClinChek® Amino Acids
10280-10282
198
Immunoglobuline M (IgM)
●#
ClinChek® CSF/Serum Quotients
Homocysteine
●
ClinChek® Homocysteine
23080-23082
MS2182
200
207
Indinavir
●
ClinChek® Antiretrovirals
8820-8822
196
Iodide
Homovanillic acid (HVA)
ClinChek® Biogenic Amines
●
●
●
HVA (Homovanillic acid)
●
ClinChek® Biogenic Amines
8820-8822
196
MS6082
203
8717
205
Isoleucine
Isovalerylcarnitine
Iron
α-Hydroxyalprazolam
●
ClinChek® Benzodiazepines
Hydroxybupropion
●
ClinChek® Psychoactive Drugs TDM6
10-Hydroxy-Carbamazepine
●
ClinChek® Antiepileptics
15080-15082
ClinChek® Antiepileptics 2
15282
ClinChek® Antiepileptics 3
14080-14082
ClinChek® Psychoactive Drugs TDM1
8702
202
202
202
204
MS3080-3083
197
8820-8822
196
●
●
●
●
●
●
ClinChek® Nicotine and Metabolites
5-Hydroxyindoleacetic acid (5-HIAA)
●
ClinChek® Biogenic Amines
Hydroxy-Itraconazole
ClinChek® Antimycotics
8839
199
ClinChek® Benzodiazepines
MS6082
203
●
ClinChek® Amino Acids
ClinChek® Biogenic Amines
10280-10282
8820-8822
198
196
●
ClinChek® Phenolic Compounds
8925
198
●
α-Hydroxymidazolam
●
Hydroxyproline
●
ClinChek® Amino Acids
●
●
Itraconazole
●
Keppra® (Levetiracetam)
3-Hydroxycotinine
●
●
Lacosamide
●
●
●
●
1-Hydroxypyrene
Lead
9-Hydroxy-Risperidone
(Paliperidone)
●
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Risperidone, Paliperidone 40180-40182
204
199
α-Hydroxytriazolam
●
ClinChek® Benzodiazepines
MS6082
203
25-Hydroxy-Vitamin D2
●
ClinChek® 25-OH Vitamins D2 / D3
35080-35082
MS7080-7082
205
205
Levetiracetam (Keppra®)
35080-35082
MS7080-7082
205
205
Lithium
●
●
●
Leucine
●
25-Hydroxy-Vitamin D3
●
ClinChek® 25-OH Vitamins D2 / D3
●
#
186
Page
21080-21082
Histidine
●
Order No.
●
●
●
●
●
●
IgA (Immunoglobuline A)
●#
ClinChek® CSF/Serum Quotients
8605
203
Lopinavir
●
ClinChek® Antiretrovirals
MS4082
202
IgG (Immunoglobuline G)
●#
ClinChek® CSF/Serum Quotients
8605
203
Lorazepam
●
ClinChek® Benzodiazepines
MS6082
203
Serum and CSF
#
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
Serum and CSF
187
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 188
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Lormetazepam
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® Benzodiazepines
●
Order No.
Page
Analyte
(alphabetical)
MS6082
203
3-Methoxytyramine
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® Biogenic Amines
ClinChek® Metanephrines
●
❍
Lysine
Magnesium
ClinChek® Amino Acids
●
10280-10282
198
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
32080-32082
201
ClinChek® Acylcarn. a. Amino Acids
10182
206
ClinChek® Trace Elements
●
●
●
●
Malondialdehyde
ClinChek® Malondialdehyde
●
Malonylcarnitine
●
8922
197
N-Methylformamide
●
ClinChek® Parameters for
Occupational Medicine
8922
197
m/p-Methyl-hippuric acid
●
ClinChek® Parameters for
Occupational Medicine
8922
197
o-Methyl-hippuric acid
●
ClinChek® Parameters for
Occupational Medicine
8922
197
8922
197
Manganese
●
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
8711
204
Methylmalonylcarnitine
1-Methyl-histidine
●
ClinChek® Amino Acids
10280-10282
198
3-Methyl-histidine
●
ClinChek® Amino Acids
10280-10282
198
ClinChek® Methylmalonic Acid
MS5080-5082
204
10182
206
ClinChek® Psychoactive Drugs TDM6
8717
205
ClinChek® Parameters for
Environmental Medicine
8928
197
MS6082
203
Methylmalonic Acid
●
Maprotiline
●
ClinChek® Psychoactive Drugs TDM4
Maraviroc
●
ClinChek® Antiretrovirals
MS4082
202
Mianserin
ClinChek® Parameters for
Environmental Medicine
8928
197
MiBP (Mono-iso-butylphthalate)
MS6082
203
Midazolam
●
ClinChek® Benzodiazepines
ClinChek® Parameters for
Environmental Medicine
8928
197
Mirtazapine
●
ClinChek® Psychoactive Drugs TDM2
ClinChek® Psychoactive Drugs TDM6
8705
8717
204
205
ClinChek® Parameters for
Environmental Medicine
8928
197
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
MBzP (Mono-benzylphthalate)
●
Medazepam
ClinChek® Benzodiazepines
●
●
●
●
5-OH-MEHP [Mono-(2-ethyl5-hydroxyhexyl) phthalate]
●
5-oxo-MEHP [Mono-(2-ethyl5-oxohexyl) phthalate]
●
ClinChek® Parameters for
Environmental Medicine
8928
197
MnBP (Mono-n-butylphthalate)
●
5-cx-MEPP [Mono-(2-ethyl5-carboxypentyl) phthalate]
●
ClinChek® Parameters for
Environmental Medicine
8928
197
Molybdenum
●
Mercury
●
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
8820-8822
MS11080-11082
196
xxx
10182
10280-10282
206
198
8922
197
●
ClinChek® Acylcarn. a. Amino Acids
●
●
●
●
●
Metanephrine
ClinChek® Biogenic Amines
ClinChek® Metanephrines
●
❍
Methionine
●
●
Methoxy acetic acid
●
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
ClinChek® Parameters for
Occupational Medicine
Monomethylarsonic Acid
●
ClinChek® Arsenic Species
8931
196
t,t-Muconic Acid
●
ClinChek® Parameters for
Occupational Medicine
8922
197
29080-29083
201
Mycophenolic Acid
ClinChek® Mycophenolic Acid
●
1-Naphthol
●
ClinChek® Phenolic Compounds
8925
198
2-Naphthol
●
ClinChek® Phenolic Compounds
8925
198
15080-15082
14180-14182
202
202
NDMS (N-Desmethylmethsuximide)
●
●
188
196
xxx
ClinChek® Parameters for
Occupational Medicine
ClinChek® Parameters for
Occupational Medicine
●
8820-8822
MS11080-11082
●
●
●
Page
Methylenedianiline
Mandelic acid
●
Order No.
ClinChek® Antiepileptics
ClinChek® Antiepileptics 4
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
189
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 190
With ClinChek® Control Materials the following analytes
are available:
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
Nelfinavir
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® Antiretrovirals
●
Nevirapine
ClinChek® Antiretrovirals
●
Order No.
Page
Analyte
(alphabetical)
MS4082
202
MS4082
202
ClinChek® Trace Elements
●
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
●
●
●
MS3080-3083
197
Urine
Paliperidone
(9-Hydroxy-Risperidone)
Palladium
Nickel
Matrix
Plasma Serum
ClinChek® Nicotine and Metabolites
●
Nitrazepam
●
ClinChek® Benzodiazepines
MS6082
203
Norclobazam
●
ClinChek® Benzodiazepines
MS6082
203
Whole
● = available
Blood
❍ = in preparation
●
●
●
●
ClinChek® Psychoactive Drugs TDM4
8711
●
●
ClinChek® Atypical Neuroleptics
40080-40082
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Psychoactive Drugs TDM4
8711
199
204
204
Nordiazepam
●
ClinChek® Benzodiazepines
MS6082
203
Nordoxepin
●
ClinChek® Psychoactive Drugs TDM4
8711
204
8820-8822
8809-8811
2180-2182
196
199
196
ClinChek® Benzodiazepines
MS6082
203
ClinChek® Biogenic Amines
ClinChek® Metanephrines
8820-8822
MS11080-11082
196
xxx
ClinChek® Psychoactive Drugs TDM4
8711
204
ClinChek® Acylcarn. a. Amino Acids
10182
206
Norepinephrine
●
ClinChek® Biogenic Amines
●
●
ClinChek® Catecholamines (FD)
●
Norflunitrazepam
Normetanephrine
●
●
❍
Nortriptyline
●
Octadecanoylcarnitine
●
●
ClinChek® Acylcarn. a. Amino Acids
10182
●
●
Ornithine
●
●
ortho-Cresol
197
PBG (Porphobilinogen)
●
ClinChek® 5-ALA / PBG
ClinChek® Porphyrins
17280-17282
17080-17082
196
198
ClinChek® Antiepileptics
15080-15082
202
17080-17082
198
8925
198
21080-21082
203
204
●
Pentacarboxyporphyrin I
●
ClinChek® Porphyrins
Pentachlorophenol
●
ClinChek® Phenolic Compounds
Pentasialotransferrin
●
ClinChek® CDT
Perampanel
●
ClinChek® Antiepileptics 2
15282
202
Perazine
●
ClinChek® Psychoactive Drugs TDM1
8702
204
Phenobarbital
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
●
Phenol
●
ClinChek® Phenolic Compounds
8925
198
3-Phenoxybenzoic acid (3-PBA)
●
ClinChek® Parameters for
Environmental Medicine
8928
197
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
ClinChek® Antiepileptics
15080-15082
202
Phenylalanine
●
206
●
●
ClinChek® Parameters for
Occupational Medicine
8922
197
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
S-Phenylmercapturic acid
●
ClinChek® Parameters for
Occupational Medicine
8922
197
8925
198
MS6082
203
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
15080-15082
15282
14080-14082
202
202
202
ClinChek® Amino Acids
10280-10282
198
Phenytoin (Diphenylhydantoin)
190
8928
Phenylglyoxylic acid
●
ClinChek® Benzodiazepines
Oxcarbazepine
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 3
●
205
199
204
Oxazepam
●
8717
ClinChek® Atypical Neuroleptics
40080-40082
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Phenolic Compounds
●
ClinChek® Psychoactive Drugs TDM6
ClinChek® Parameters for
Environmental Medicine
Phenylethyl-malonamide (PEMA)
Olanzapine
198
201
205
207
●
●
Octanoylcarnitine
8847-8849
8883-8885
8880-8882
8840-8843
3-PBA (3-Phenoxybenzoic acid)
PEMA (Phenylethyl-malonamide)
Norclozapine
(Desmethylclozapine)
ClinChek® Trace Elements
●
●
Norclomipramine
Page
204
199
●
●
Order No.
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Risperidone, Paliperidone 40180-40182
●
Paroxetine
Nicotine
ClinChek® Control
ClinChek®
Analyte Survey
●
●
Phosphoserine
●
191
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 192
Analyte
(alphabetical)
Platinum
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
ClinChek® Trace Elements
●
Posaconazole
●
(alphabetical)
Matrix
Urine
●
Whole
● = available
Blood
❍ = in preparation
8717
205
Sertraline
●
ClinChek® Psychoactive Drugs TDM6
8717
205
ClinChek® Antimycotics
8839
199
ClinChek® Trace Elements
ClinChek® Trace Elements
8840-8843
207
8883-8885
8880-8882
8840-8843
201
205
207
MS6082
203
ClinChek® Immunosuppressants
8830-8833
207
15282
202
15282
14080-14082
15180-15182
202
202
200
8830-8833
207
10280-10282
198
MS6082
203
10182
206
21080-21082
203
●
ClinChek® Antiepileptics 2
15282
202
●
●
●
Primidone
●
ClinChek® Antiepileptics
ClinChek® Antiepileptics 3
15080-15082
14080-14082
202
202
Sirolimus
●
Stiripentol
●
ClinChek® Antiepileptics 2
Sulthiame
●
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 3
ClinChek® Lamotrigine a. Sulthiame
●
Pyridoxal (Vitamin B6)
ClinChek® Amino Acids
●
10280-10282
198
10182
206
Tacrolimus
ClinChek® Vitamins
8870-8873
8874-8876
206
207
Taurine
ClinChek® Vitamins
8870-8873
8874-8876
206
207
ClinChek® Acylcarn. a. Amino Acids
●
●
●
●
●
Quetiapine
●
199
204
204
204
Raltegravir
●
ClinChek® Antiretrovirals
MS4082
202
Retigabine
●
ClinChek® Antiepileptics 2
15282
202
Retinol, all-trans (Vitamin A)
●
ClinChek® Vitamins
8870-8873
206
Theobromine
●
ClinChek® Psychoactive Drugs TDM3
8708
ClinChek® Risperidone, Paliperidone 40180-40182
204
199
Theophylline
Ritonavir
●
ClinChek® Antiretrovirals
MS4082
202
Rufinamide
●
●
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 4
15282
14180-14182
202
202
●
ClinChek® Antiretrovirals
MS4082
202
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
●
●
ClinChek® Benzodiazepines
●
Tetradecanoylcarnitine
ClinChek® Atypical Neuroleptics
40080-40082
ClinChek® Psychoactive Drugs TDM1
8702
ClinChek® Psychoactive Drugs TDM2
8705
ClinChek® Psychoactive Drugs TDM3
8708
●
ClinChek® Immunosuppressants
ClinChek® Amino Acids
●
Temazepam
Pyridoxal-5-phosphate
(Vitamin B6)
●
ClinChek® Acylcarn. a. Amino Acids
Tetrasialotransferrin
●
ClinChek® CDT
Tetrazepam
●
ClinChek® Benzodiazepines
MS6082
203
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
●
ClinChek® Antiasthmatics
12080-12082
199
●
ClinChek® Antiasthmatics
12080-12082
199
8874-8876
207
10280-10282
198
ClinChek® Antiepileptics 2
15282
202
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
MS4082
202
Thallium
●
●
●
Risperidone
●
●
Thiaminepyrophosphate (TPP,
Vitamin B1)
●
Threonine
Tin
Selenium
ClinChek® Trace Elements
●
●
●
●
192
ClinChek® Vitamins
ClinChek® Amino Acids
●
Tiagabine
Saquinavir
196
199
ClinChek® Psychoactive Drugs TDM6
Pregabaline
●
8820-8822
8809-8811
●
ClinChek® Biogenic Amines
●
●
Propionylcarnitine
198
Sertindole
ClinChek® Benzodiazepines
●
10280-10282
196
198
●
Proline
Page
17280-17282
17080-17082
Prazepam
●
Order No.
ClinChek® 5-ALA / PBG
ClinChek® Porphyrins
Serotonin
ClinChek® Amino Acids
●
Silver
Potassium
Plasma Serum
ClinChek® Control
Serine
●
●
Analyte
198
201
205
207
●
●
Page
8847-8849
8883-8885
8880-8882
8840-8843
●
Porphobilinogen (PBG)
Order No.
●
●
●
●
Tipranavir
●
ClinChek® Antiretrovirals
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
193
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:34 Seite 194
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
α-Tocopherol (Vitamin E)
●
ClinChek® Vitamins
Topiramat
●
ClinChek® Antiepileptics 2
Total porphyrins
ClinChek® 5-ALA / PBG
ClinChek® Porphyrins
●
●
Total protein
●#
ClinChek® CSF/Serum Quotients
TPP (Thiaminepyrophosphate,
Vitamin B1)
●
ClinChek® Vitamins
Trazodone
●
Order No.
Page
Analyte
(alphabetical)
Matrix
Urine
Plasma Serum
ClinChek® Control
Whole
● = available
Blood
❍ = in preparation
206
Vitamin B1
●
ClinChek® Vitamins
8874-8876
207
15282
202
Vitamin B2
●
ClinChek® Vitamins
8874-8876
207
17280-17282
17080-17082
196
198
Vitamin B6
ClinChek® Vitamins
8870-8873
8874-8876
206
207
8605
203
Vitamin C
●
ClinChek® Vitamin C
28080-28082
205
8874-8876
207
Vitamin D2
●
ClinChek® 25-OH Vitamins D2 / D3
35080-35082
MS7080-7082
205
205
ClinChek® 25-OH Vitamins D2 / D3
35080-35082
MS7080-7082
205
205
●
●
MS6082
203
Vitamin D3
●
●
Triazolam
Trichloroacetic acid
ClinChek® Benzodiazepines
●
●
MS6082
203
ClinChek® Parameters for
Occupational Medicine
8922
197
8711
204
Voriconazole
Vitamin E
●
ClinChek® Vitamins
8870-8873
206
VMA (Vanillylmandelic acid)
●
ClinChek® Biogenic Amines
8820-8822
196
8839
199
ClinChek® Benzodiazepines
MS6082
203
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
8840-8843
198
201
205
207
8708
204
MS6082
203
15282
14180-14182
202
202
MS6082
203
Trimipramine
●
ClinChek® Psychoactive Drugs TDM4
Trisialotransferrin
●
ClinChek® CDT
21080-21082
203
Zaleplon
ClinChek® Amino Acids
10280-10282
198
Zinc
Tryptophane
●
ClinChek® Antimycotics
●
●
●
●
Tyrosine
●
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
Ubiquinone (Coenzyme Q10)
●
ClinChek® Coenzyme Q10
31080-31082
200
Ziprasidone
●
ClinChek® Psychoactive Drugs TDM3
Urea
●
ClinChek® Amino Acids
10280-10282
198
Zolpidem
●
ClinChek® Benzodiazepines
ClinChek® Porphyrins
17080-17082
198
Zonisamide
●
●
ClinChek® Antiepileptics 2
ClinChek® Antiepileptics 4
●
ClinChek® Benzodiazepines
Uroporphyrin I
●
●
Valine
ClinChek® Acylcarn. a. Amino Acids
ClinChek® Amino Acids
10182
10280-10282
206
198
ClinChek® Antiepileptics
15080-15082
202
ClinChek® Trace Elements
8847-8849
8883-8885
8880-8882
198
201
205
ClinChek® Biogenic Amines
8820-8822
196
●
ClinChek® Psychoactive Drugs TDM1
ClinChek® Psychoactive Drugs TDM2
ClinChek® Psychoactive Drugs TDM6
8702
8705
8717
204
204
205
Vigabatrine
●
ClinChek® Antiepileptics 2
15282
202
Vitamin A
●
ClinChek® Vitamins
8870-8873
206
●
●
Valproic acid
Vanadium
●
●
●
●
Vanillylmandelic acid (VMA)
Venlafaxine
●
●
●
#
194
Page
8870-8873
●
ClinChek® Benzodiazepines
Order No.
●
●
Zopiclone
ClinChek®
With ClinChek® Control Materials the following analytes
are available:
Analyte Survey
Serum and CSF
195
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Product Survey
The analytes listed in the Analyte Survey (see pages 180 - 195) are included in the following
ClinChek® Urine, Plasma, Serum, and Whole Blood Controls:
Ethylglucuronide
■ Analytes:
Ethylglucuronide, ethylsulfate
ClinChek® Urine Controls, Lyophilised:
Order no.
Description
Quantity
MS8080
ClinChek Urine Control, lyophil., for Ethylglucuronide, Level I
10 x 1 ml
MS8081
ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level II
10 x 1 ml
MS8082
ClinChek® Urine Control, lyophil., for Ethylglucuronide, Level III
10 x 1 ml
MS8083
ClinChek Urine Control, lyophil., for Ethylglucuronide, Level I, II, III
®
®
3 x 3 x 1 ml
5-ALA, PBG, Total Porphyrins
■ Analytes:
Nicotine and Metabolites
5-Aminolevulinic acid (5-ALA), porphobilinogen (PBG), total porphyrins
Order no.
Description
Quantity
■ Analytes:
17280
ClinChek Urine Control, lyophil., for 5-ALA, PBG, Level I
10 x 5 ml
Cotinine, 3ʼ-hydroxycotinine, nicotine
17281
ClinChek® Urine Control, lyophil., for 5-ALA, PBG, Level II
10 x 5 ml
Order no.
Description
17282
ClinChek® Urine Control, lyophil., for 5-ALA, PBG, Level I, II
MS3080
ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level I
5 x 3 ml
MS3081
ClinChek Urine Control, lyophil., for Nicotine and Metabolites, Level II
5 x 3 ml
MS3082
ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level III
MS3083
ClinChek® Urine Control, lyophil., for Nicotine and Metabolites, Level I, II, III
®
2 x 5 x 5 ml
Arsenic Species
®
Quantity
5 x 3 ml
3 x 2 x 3 ml
■ Analytes:
Arsenic III, arsenic V, arsenobetaine, dimethylarsinic acid, monomethylarsonic acid
Order no.
Description
8931
ClinChek® Urine Control, lyophil., for Arsenic Species, Level I, II
Quantity
2 x 5 x 5 ml
Parameters for Environmental Medicine
■ Analytes:
Br2-CA [3-(2,2-dibromovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid],
trans-Cl2-CA [trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid],
■ Analytes:
MBzP [Mono-benzylphthalate], 5-OH-MEHP [Mono-(2-ethyl-5-hydroxyhexyl)phthalate],
Dopamine, epinephrine, homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), hydroxyproline,
5-oxo-MEHP [Mono-(2-ethyl-5-oxohexyl)phthalate], 5-cx-MEPP [Mono-(2-ethyl-5-
metanephrine, 3-methoxytyramine, norepinephrine, normetanephrine, serotonin, vanillylmandelic acid (VMA)
carboxypentyl)phthalate], MiBP [Mono-iso-butylphthalate], MnBP [Mono-n-butylphthalate],
Order no.
Description
Quantity
3-PBA [3-phenoxybenzoic acid]
8820
ClinChek® Urine Control, lyophil., for Biogenic Amines, Level I
10 x 8 ml
Order no.
Description
8821
ClinChek® Urine Control, lyophil., for Biogenic Amines, Level II
10 x 8 ml
8928
ClinChek® Urine Control, lyophil., for Environmental Medicine, Level I, II
8822
ClinChek® Urine Control, lyophil., for Biogenic Amines, Level I, II
ClinChek®
cis-Cl2-CA [cis-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropan-1-carboxylic acid],
Biogenic Amines
Quantity
2 x 5 x 5 ml
2 x 5 x 8 ml
Parameters for Occupational Medicine
Catecholamines
■ Analytes:
■ Analytes:
Butoxy acetic acid, ethoxy acetic acid, hippuric acid, mandelic acid, methoxy acetic acid,
Dopamine, epinephrine, norepinephrine
196
methylenedianiline, N-methyl-formamide, m/p-methyl-hippuric acid, o-methyl-hippuric acid,
Order no.
Description
Quantity
t,t-muconic acid, phenylglyoxylic acid, S-phenylmercapturic acid, trichloroacetic acid
2180
ClinChek® Urine Control, lyophil., for Catcholamines (FD), Level I
10 x 5 ml
Order no.
Description
2181
ClinChek Urine Control, lyophil., for Catcholamines (FD), Level II
10 x 5 ml
8922
ClinChek Urine Control, lyophil., for Occupational Medicine, Level I, II
2182
ClinChek® Urine Control, lyophil., for Catcholamines (FD), Level III
2 x 5 x 5 ml
®
®
Quantity
2 x 5 x 5 ml
197
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Product Survey
Phenolic Compounds
Antiasthmatics
■ Analytes:
■ Analytes:
Bisphenol A, o-cresol, 1-hydroxypyrene, 1-naphthol, 2-naphthol, pentachlorophenol, phenol
Order no.
Description
8925
ClinChek Urine Control, lyophil., for Phenolic Compounds, Level I, II
®
Caffeine, theobromine, theophylline
Quantity
2 x 5 x 5 ml
Order no.
Description
Quantity
10 x 3 ml
12080
ClinChek Plasma Control, lyophil., for Antiasthmatics, Level I
12081
ClinChek® Plasma Control, lyophil., for Antiasthmatics, Level II
12082
ClinChek® Plasma Control, lyophil., for Antiasthmatics, Level I, II
®
10 x 3 ml
2 x 5 x 3 ml
Porphyrins
■ Analytes:
Antimycotics
5-Aminolevulinic acid (5-ALA), coproporphyrin I, coproporphyrin III, heptacarboxyporphyrin I,
hexacarboxyporphyrin Iac + Iab, pentacarboxyporphyrin I, porphobilinogen (PBG), total porphyrins,
■ Analytes:
uroporphyrin I
Fluconazole, hydroxy-itraconazole, itraconazole, posaconazole, voriconazole
Order no.
Description
Quantity
Order no.
Description
17080
ClinChek® Urine Control, lyophil., for Porphyrins, Level I
10 x 5 ml
8839
ClinChek® Plasma Control, lyophil., for Antimycotics, Level I, II, III
17081
ClinChek® Urine Control, lyophil., for Porphyrins, Level II
10 x 5 ml
17082
ClinChek Urine Control, lyophil., for Porphyrins, Level I, II
®
Quantity
3 x 2 x 1 ml
2 x 5 x 5 ml
Atypical Neuroleptics
■ Analytes:
Trace Elements
Clozapine, desmethylclozapine, desmethylolanzapine, olanzapine, quetiapine
■ Analytes:
Order no.
Description
Quantity
Al, As, Be, Cd, Co, Cr, Cu, Fluoride, Fe, Hg, Iodide, Mg, Mn, Mo, Ni, Pb, Pd, Pt, Sb, Se, Sn, Tl, V, Zn
10 x 3 ml
Description
8847
ClinChek® Urine Control, lyophil., for Trace Elements, Level I
8848
ClinChek® Urine Control, lyophil., for Trace Elements, Level II
8849
ClinChek® Urine Control, lyophil., for Trace Elements, Level I, II
40080
ClinChek Plasma Control, lyophil., for Atypical Neuroleptics, Level I
Quantity
40081
ClinChek® Plasma Control, lyophil., for Atypical Neuroleptics, Level II
10 x 10 ml
40082
ClinChek® Plasma Control, lyophil., for Atypical Neuroleptics, Level I, II
10 x 3 ml
2 x 5 x 3 ml
10 x 10 ml
2 x 5 x 10 ml
ClinChek®
Order no.
®
■ Analytes:
Paliperidone (9-hydroxy-risperidone), risperidone
ClinChek® Plasma Controls, Lyophilised:
Order no.
Description
Quantity
40180
ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level I
10 x 5 ml
40181
ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level II
40182
ClinChek® Plasma Control, lyophil., for Risperidone, Paliperidone, Level I, II
10 x 5 ml
2 x 5 x 5 ml
Amino Acids (by Amino Acid Analyser)
198
■ Analytes:
Biogenic Amines
Alanine, α-aminobutyric acid, arginine, asparagine, aspartic acid, citrulline, glutamic acid, glutamine,
■ Analytes:
glycine, histidine, hydroxyproline, isoleucine, leucine, lysine, methionine, 1-methyl-histidine,
Dopamine, epinephrine, norepinephrine, serotonin
3-methyl-histidine, ornithine, phenylalanine, phosphoserine, proline, serine, taurine, threonine,
Order no.
Description
Quantity
tryptophane, tyrosine, urea, valine
10 x 5 ml
8810
ClinChek Plasma Control, lyophil., for Biogenic Amines, Level I
Order no.
Description
Quantity
8811
ClinChek® Plasma Control, lyophil., for Biogenic Amines, Level II
10280
ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level I
10 x 3 ml
8809
ClinChek® Plasma Control, lyophil., for Biogenic Amines, Level I, II
10281
ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level II
10282
ClinChek® Plasma Control, lyophil., for Amino Acids (by Amino Acid Analyser), Level I, II
®
10 x 5 ml
2 x 5 x 5 ml
10 x 3 ml
2 x 5 x 3 ml
199
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Product Survey
β-Carotene
Malondialdehyde
■ Analytes:
■ Analytes:
See title
See title
Order no.
Description
Quantity
Order no.
Description
30080
ClinChek Plasma Control, lyophil., for β-Carotene, Level I
10 x 2 ml
32080
ClinChek Plasma Control, lyophil., for Malondialdehyde, Level I
30081
ClinChek® Plasma Control, lyophil., for β-Carotene, Level II
10 x 2 ml
32081
ClinChek® Plasma Control, lyophil., for Malondialdehyde, Level II
30082
ClinChek® Plasma Control, lyophil., for β-Carotene, Level I, II
2 x 5 x 2 ml
32082
ClinChek® Plasma Control, lyophil., for Malondialdehyde, Level I, II
®
Coenzyme Q10
®
Quantity
10 x 0.5 ml
10 x 0.5 ml
2 x 5 x 0.5 ml
Mycophenolic Acid
■ Analytes:
■ Analytes:
See title
See title
Order no.
Description
Quantity
Order no.
Description
Quantity
31080
ClinChek® Plasma Control, lyophil., for Coenzyme Q10, Level I
10 x 2 ml
29080
ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level I
10 x 3 ml
31081
ClinChek® Plasma Control, lyophil., for Coenzyme Q10, Level II
10 x 2 ml
29081
ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level II
10 x 3 ml
31082
ClinChek Plasma Control, lyophil., for Coenzyme Q10, Level I, II
2 x 5 x 2 ml
29082
ClinChek Plasma Control, lyophil., for Mycophenolic Acid, Level III
29083
ClinChek® Plasma Control, lyophil., for Mycophenolic Acid, Level I, II, III
®
®
10 x 3 ml
3 x 3 x 3 ml
Homocysteine
■ Analytes:
Trace Elements
Order no.
Description
Quantity
Ag, Al, As, Au, Be, Bi, Cd, Co, Cr, Cu, Fluoride, Hg, Iodide, Li, Mg, Mn, Mo, Ni, Pd, Pt,
23080
ClinChek® Plasma Control, lyophil., for Homocysteine, Level I
10 x 3 ml
Sb, Se, Sn, Tl, V, Zn
23081
ClinChek Plasma Control, lyophil., for Homocysteine, Level II
10 x 3 ml
Order no.
Description
Quantity
23082
ClinChek® Plasma Control, lyophil., for Homocysteine, Level I, II
8883
ClinChek® Plasma Control, lyophil., for Trace Elements, Level I
10 x 3 ml
8884
ClinChek® Plasma Control, lyophil., for Trace Elements, Level II
10 x 3 ml
8885
ClinChek Plasma Control, lyophil., for Trace Elements, Level I, II
®
2 x 5 x 3 ml
®
ClinChek®
■ Analytes:
See title
2 x 5 x 3 ml
Lamotrigine and Sulthiame
■ Analytes:
See title
Order no.
Description
15180
ClinChek Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level I
10 x 3 ml
15181
ClinChek® Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level II
10 x 3 ml
15182
ClinChek® Plasma Control, lyophil., for Lamotrigine and Sulthiame, Level I, II
®
Quantity
2 x 5 x 3 ml
ClinChek® Serum Controls, Lyophilised:
Amiodarone
■ Analytes:
Amiodarone, desethylamiodarone
200
Order no.
Description
Quantity
20080
ClinChek® Serum Control, lyophil., for Amiodarone, Level I
10 x 3 ml
20081
ClinChek® Serum Control, lyophil., for Amiodarone, Level II
10 x 3 ml
20082
ClinChek Serum Control, lyophil., for Amiodarone, Level I, II
®
2 x 5 x 3 ml
201
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Product Survey
Antiepileptics
Benzodiazepines
■ Analytes:
■ Analytes:
Bromide, carbamazepine, carbamazepine-epoxide, N-desmethylmethsuximide, ethosuximide,
Alprazolam, 7-aminoclonazepam, 7-aminoflunitrazepam, 7-aminonitrazepam, bromazepam,
10-hydroxy-carbamazepine, oxcarbazepine, PEMA, phenobarbital, phenytoin, primidone, valproic acid
chlordiazepoxide, clobazam, clonazepam, demoxepam, desalkylflurazepam, diazepam,
Order no.
Description
Quantity
estazolam, flunitrazepam, flurazepam, α-hydroxyalprazolam, α-hydroxymidazolam,
15080
ClinChek® Serum Control, lyophil., Antiepileptics, Level I
10 x 3 ml
α-hydroxytriazolam, lorazepam, lormetazepam, medazepam, midazolam, nitrazepam,
15081
ClinChek® Serum Control, lyophil., Antiepileptics, Level II
10 x 3 ml
norclobazam, nordiazepam, norflunitrazepam, oxazepam, prazepam, temazepam, tetrazepam,
15082
ClinChek Serum Control, lyophil., Antiepileptics, Level I, II
®
2 x 5 x 3 ml
■ Analytes:
trazodone, triazolam, zaleplon, zolpidem, zopiclone
Order no.
Description
MS6082
ClinChek® Serum Control, lyophil., for Benzodiazepines, Level I, II
Quantity
2 x 5 x 1 ml
Felbamate, gabapentine, 10-hydroxy-carbamazepine, lacosamide, lamotrigine, levetiracetam,
oxcarbazepine, perampanel, pregabaline, retigabine, rufinamide, stiripentol, sulthiame, tiagabine,
CDT
topiramate, vigabatrine, zonisamide
Order no.
Description
15282
ClinChek® Serum Control, lyophil., Antiepileptics 2, Level I, II
Quantity
2 x 5 x 2 ml
■ Analytes:
A-, di-, tri-, tetra-, penta-, hexasialotransferrin
Order no.
Description
Quantity
■ Analytes:
21080
ClinChek® Serum Control, lyophil., for CDT, Level I
10 x 1 ml
Carbamazepine, carbamazepine-epoxide, ethosuximide, 10-hydroxy-carbamazepine, lamotrigine,
21081
ClinChek® Serum Control, lyophil., for CDT, Level II
10 x 1 ml
oxcarbazepine, phenobarbital, phenytoin, primidone, sulthiame
21082
ClinChek Serum Control, lyophil., for CDT, Level I, II
Order no.
Description
Quantity
14080
ClinChek® Serum Control, lyophil., Antiepileptics 3, Level I
10 x 3 ml
14081
ClinChek® Serum Control, lyophil., Antiepileptics 3, Level II
14082
ClinChek® Serum Control, lyophil., Antiepileptics 3, Level I, II
10 x 3 ml
2 x 5 x 3 ml
®
2 x 5 x 1 ml
CSF/Serum Quotients
■ Analytes:
Order no.
Description
N-Desmethylmethsuximide, felbamate, lacosamide, rufinamide, zonisamide
8605
ClinChek® CSF/Serum Control, lyophil., for CSF/Serum Quotients, Level I, II
Order no.
Description
Quantity
14180
ClinChek® Serum Control, lyophil., Antiepileptics 4, Level I
10 x 3 ml
14181
ClinChek® Serum Control, lyophil., Antiepileptics 4, Level II
14182
ClinChek® Serum Control, lyophil., Antiepileptics 4, Level I, II
10 x 3 ml
2 x 5 x 3 ml
ClinChek®
Albumin, glucose, IgA, IgG, IgM, lactate, total protein
■ Analytes:
Quantity
4 x 2 x 1 ml
Drugfree
■ Analytes:
Blank matrix
Order no.
Description
Antiretrovirals
8850
ClinChek® Serum Control, lyophil., Drugfree (animal origin)
10 x 10 ml
■ Analytes:
8851
ClinChek® Serum Control, lyophil., Drugfree (human origin)
10 x 5 ml
Amprenavir, atazanavir, darunavir, delavirdine, efavirenz, etravirine, indinavir, lopinavir,
8850B
ClinChek Serum Control, frozen, Drugfree (animal origin)
500 ml
maraviroc, nelfinavir, nevirapine, raltegravir, ritonavir, saquinavir, tipranavir
8851B
ClinChek® Serum Control, frozen, Drugfree (human origin)
500 ml
Order no.
Description
MS4082
ClinChek® Serum Control, lyophil., for Antiretrovirals, Level I, II
®
Quantity
Quantity
2 x 5 x 0.5 ml
Ethylglucuronide
■ Analytes:
Ethylglucuronide, ethylsulfate
202
Order no.
Description
Quantity
MS8180
ClinChek Serum Control, lyophil., for Ethylglucuronide, Level I
10 x 1 ml
MS8181
ClinChek® Serum Control, lyophil., for Ethylglucuronide, Level II
10 x 1 ml
MS8182
ClinChek Serum Control, lyophil., for Ethylglucuronide, Level I, II
®
®
2 x 5 x 1 ml
203
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Product Survey
Levetiracetam (Keppra®)
Psychoactive Drugs TDM 6
■ Analytes:
■ Analytes:
See title
Aripiprazole, bupropion, citalopram, desmethylfluoxetine, desmethylsertraline,
Order no.
Description
Quantity
O-desmethylvenlafaxine, duloxetine, fluoxetine, fluvoxamine, hydroxybupropion,
15580
ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level I
10 x 3 ml
mianserin, mirtazapine, paroxetine, sertindole, sertraline, venlafaxine
15581
ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level II
10 x 3 ml
Order no.
Description
15582
ClinChek® Serum Control, lyophil., for Levetiracetam (Keppra®), Level I, II
8717
ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM6, Level I, II
2 x 5 x 3 ml
Methylmalonic Acid
Quantity
2 x 5 x 5 ml
Trace Elements
■ Analytes:
■ Analytes:
See title
Ag, Al, As, Au, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Fluoride, Hg, Li, Mg, Mn, Mo, Ni,
Order no.
Description
Quantity
Pd, Pt, Sb, Se, Sn, Tl, V, Zn
MS5080
ClinChek Serum Control, lyophil., for Methylmalonic Acid, Level I
10 x 2 ml
Order no.
Description
Quantity
MS5081
ClinChek® Serum Control, lyophil., for Methylmalonic Acid, Level II
10 x 2 ml
8880
ClinChek® Serum Control, lyophil., for Trace Elements, Level I
10 x 3 ml
MS5082
ClinChek® Serum Control, lyophil., for Methylmalonic Acid, Level I, II
2 x 5 x 2 ml
8881
ClinChek® Serum Control, lyophil., for Trace Elements, Level II
8882
ClinChek® Serum Control, lyophil., for Trace Elements, Level I, II
®
10 x 3 ml
2 x 5 x 3 ml
Psychoactive Drugs TDM 1 - TDM 4
■ Analytes:
Vitamin C
■ Analytes:
perazine, quetiapine, venlafaxine
See title
Order no.
Description
8702
ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM1, Level I, II
Quantity
2 x 5 x 5 ml
■ Analytes:
Order no.
Description
28080
ClinChek Serum Control, lyophil., for Vitamin C, Level I
28081
ClinChek® Serum Control, lyophil., for Vitamin C, Level II
28082
ClinChek® Serum Control, lyophil., for Vitamin C, Level I, II
®
Quantity
10 x 0.5 ml
ClinChek®
Aripiprazole, citalopram, O-desmethylvenlafaxine, 10-hydroxy-carbamazepine, lamotrigine,
10 x 0.5 ml
2 x 5 x 0.5 ml
Amisulpride, O-desmethylvenlafaxine, escitalopram, mirtazapine, quetiapine, venlafaxine
Order no.
Description
8705
ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM2, Level I, II
Quantity
2 x 5 x 5 ml
25-OH Vitamin D2 / D3
■ Analytes:
■ Analytes:
25-hydroxy-vitamin D2, 25-hydroxy-vitamin D3
Clozapine, desmethylclozapine, duloxetine, haloperidol, olanzapine, paliperidone, quetiapine,
Order no.
Description
Quantity
risperidone, ziprasidone
35080
ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I
10 x 2 ml
Quantity
35081
ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level II
10 x 2 ml
2 x 5 x 5 ml
35082
ClinChek Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I, II
MS7080
ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I
■ Analytes:
MS7081
ClinChek Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level II
Amitriptyline, clomipramine, clozapine, desipramine, desmethylclozapine, doxepin, imipramine,
MS7082
ClinChek® Serum Control, lyophil., for 25-OH Vitamin D2 / D3, Level I, II
Order no.
Description
8708
ClinChek® Serum Control, lyophil., for Psychoactive Drugs TDM3, Level I, II
®
®
2 x 5 x 2 ml
10 x 1 ml
10 x 1 ml
2 x 5 x 1 ml
maprotiline, norclomipramine, nordoxepin, nortriptyline, trimipramine
204
Order no.
Description
8711
ClinChek Serum Control, lyophil., for Psychoactive Drugs TDM4, Level I, II
®
Quantity
2 x 5 x 5 ml
205
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Product Survey
Vitamins
Hemoglobins F / A2 / S
■ Analytes:
■ Analytes:
All-trans-retinol (vitamin A), alpha-tocopherol (vitamin E), pyridoxal (vitamin B6), pyridoxal-5-phosphate (vitamin B6)
Hemoglobin F, hemoglobin A2
Order no.
Description
Quantity
Order no.
Description
8870
ClinChek Serum Control, lyophil., for Vitamins, Level I
10 x 5 ml
13182
ClinChek Hemolysate Control, ready to use, for Hemoglobins F / A2, Level I, II
8871
ClinChek® Serum Control, lyophil., for Vitamins, Level II
10 x 5 ml
8872
ClinChek® Serum Control, lyophil., for Vitamins, Level III
10 x 5 ml
8873
ClinChek Serum Control, lyophil., for Vitamins, Level I, II, III
®
3 x 3 x 5 ml
®
Quantity
2 x 5 x 3 ml
■ Analytes:
Hemoglobin F, hemoglobin A2, hemoglobin S
13183
ClinChek® Whole Blood Controls, Lyophilised / Ready for Use:
®
ClinChek® Hemolysate Control, ready to use, for Hemoglobins F / A2 / S, Level I
5 x 3 ml
Homocysteine
■ Analytes:
See title
Acylcarnitines and Amino Acids
Order no.
Description
Analytes:
MS2182
ClinChek Whole Blood Control, filter spots, for Homocysteine, Level I, II
®
Quantity
2 x 1 x 3 spots
Acetylcarnitine, alanine, arginine, butyrylcarnitine, carnitine, citrulline, decanoylcarnitine, dodecanoylcarnitine,
glutamic acid, glutarylcarnitine, glycine, hexadecanoylcarnitine, hexanoylcarnitine, isovalerylcarnitine, leucine,
malonylcarnitine, methionine, methylmalonylcarnitine, octadecanoylcarnitine, octanoylcarnitine, ornithine,
Immunosuppressants
phenylalanine, propionylcarnitine, tetradecanoylcarnitine, tyrosine, valine
■ Analytes:
Description
10182
ClinChek® Whole Blood Control (filter spot) for
Quantity
Cyclosporine A, everolimus, sirolimus, tacrolimus
Order no.
Description
8830
ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level I
8831
ClinChek Whole Blood Control, lyophil., for Immunosuppressants, Level II
5 x 2 ml
8832
ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level III
5 x 2 ml
Hemoglobin A1c
8833
ClinChek® Whole Blood Control, lyophil., for Immunosuppressants, Level I, II, III
3 x 2 x 2 ml
■ Analytes:
8903
ClinChek Whole Blood Control, lyophil., for Immunosuppressants, Level IV, V
2 x 2 x 2 ml
Acylcarnitines and Amino Acids, Level I,II
2 x 1 x 3 spots
®
®
Quantity
5 x 2 ml
ClinChek®
Order no.
HbA1c, HbF
206
Order no.
Description
Quantity
11080
ClinChek® Hemolysate Control, ready to use, for Hemoglobin A1c, Level I
10 x 5 ml
Trace Elements
11081
ClinChek® Hemolysate Control, ready to use, for Hemoglobin A1c, Level II
10 x 5 ml
■ Analytes:
11082
ClinChek Hemolysate Control, ready to use, for Hemoglobin A1c, Level I, II
®
2 x 5 x 5 ml
Ag, As, Cd, Co, Cr, Cu, Hg, K, Mg, Mn, Ni, Pb, Pd, Pt, Se, Tl, Zn
Order no.
Description
Quantity
8840
ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level I
10 x 5 ml
Hemoglobin, free
8841
ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level II
10 x 5 ml
■ Analytes:
8842
ClinChek® Whole Blood Control, lyophil., for Trace Elements, Level III
10 x 5 ml
See title
8843
ClinChek Whole Blood Control, lyophil., for Trace Elements, Level I, II, III
®
3 x 3 x 5 ml
Order no.
Description
8812
ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level I
8813
ClinChek Hemoglobin Control, lyophil., for free Hemoglobin, Level II
9 x 1 ml
8814
ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level III
9 x 1 ml
8816
ClinChek® Hemoglobin Control, lyophil., for free Hemoglobin, Level I, II, III
3 x 3 x 1 ml
8912
ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level I
9 x 1 ml
Order no.
Description
Quantity
8913
ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level II
9 x 1 ml
8874
ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level I
10 x 2 ml
8914
ClinChek® Hemoglobin Control (low), lyophil., for free Hemoglobin, Level III
9 x 1 ml
8875
ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level II
8916
ClinChek Hemoglobin Control (low), lyophil., for free Hemoglobin, Level I, II, III
3 x 3 x 1 ml
8876
ClinChek® Whole Blood Control, lyophil., for Vitamins B1, B2, B6, Level I, II
®
®
Quantity
9 x 1 ml
Vitamins B1, B2, B6
■ Analytes:
Flavin adenine dinucleotide (FAD), pyridoxal, pyridoxal-5-phosphate (PLP), thiaminepyrophosphate (TPP)
10 x 2 ml
2 x 5 x 2 ml
207
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HPLC Instruments
ClinLab® HPLC Instruments
Chromatography Software
ClinLab® HPLC Instruments are intended for the
use in analytical laboratories.
HPLC Instruments
Our instruments are designed for routine analysis
and particularly characterised by user friendliness
and robust design. ClinLab® HPLC Instruments may
be easily combined with modular components from
other manufacturers.
209
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HPLC Instruments
ClinLab® HPLC Instruments
Autosampler
Autosampler, Model AS5000 . . . . . . . 212 - 213
Degasser
4-Channel-Degasser,
Model DG4000 . . . . . . . . . . . . . . . . . . 214 - 215
Detectors
Digital Amperometric EC Detector,
Model EC3000 . . . . . . . . . . . . . . . . . . . 216 - 217
HPLC Instruments
Fixed-Wavelength-VIS-Detector
for 460 nm, Model FW3000 . . . . . . . . 218 - 219
Universal Detector Cell for
Amperometric Detectors,
Model Sputnik® . . . . . . . . . . . . . . . . . . 220 - 221
UV/VIS-Detector, Model UV3000 . . . . 222 - 223
HPLC-Pumps
Isocratic Pump, Model IP3000 . . . . . 224 - 225
Gradient Pump, Model GP3000 . . . . . 226 - 227
HPLC-Thermostats
HPLC-Thermostat, Model HT4000 . . 228 - 229
Column Heater, Model CH3000 . . . . . 230 - 231
Chromatography Software
ClarityTM Software . . . . . . . . . . . . . . . . 232 - 233
211
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Autosampler
Autosampler,
Model AS5000
TM
Ordering Information
Specifications
General:
Sample capacity:
➜ Software controlled
➜ Suitable for any conventional HPLC System
96 samples
(2 x 48 vials, 1.5 ml)
192 samples
(2 x 96-well, high and low)
384 samples (384-well)
Sample dosing:
500 μl syringe,
sample loops (10 - 500 μl)
Analytical Performance:
RSD:
< 0.3 % (entire filling),
< 0.5 % (partial filling)
Linearity:
0.999
Injection Parameters:
Sample volume:
0 - 500 μl in 1 μl steps
Needle wash,
Loop wash:
with solvent / sample
Wash mode:
every injection /
between vials/wells
Power Supply, Dimensions, Weight:
Power supply:
95 - 240 Volt AC, 50 - 60 Hz
Power input:
200 VA
Dimensions:
300 x 510 x 360 mm
(w x d x h)
Weight:
19 kg
Order No.
Description
Quantity
AS5000
ClinLab® Autosampler, Model AS5000, complete
1 pce.
consisting of:
Autosampler, power supply cable, serial cable, fuses, user manual
AS5101
AS5102
Accessories:
Power supply cable
RS232 Serial cable
1 pce.
1 pce.
AS5201
Fuse 250 V, T 2.5 A
1 pce.
FK5000
PEEK Starterkit
contents:
Fingertight fitting, in one piece, 1/16"
Fingertight fitting, in one piece, narrow head, 1/16"
Hex head nut, 1/16"
Double ferrule, 1/16"
Union, 1/16"
Tubing, OD: 1:59 mm (= 1/16"), ID: 0.25 mm, blue
Tubing, OD: 1:59 mm (= 1/16"), ID: 0.50 mm, orange
ClinLab® Plus, cutter and flange tool
1 pce.
5
5
5
5
1
3
3
1
pcs.
pcs.
pcs.
pcs.
pce.
m
m
pce.
Sample
Sample
Sample
Sample
Sample
Sample
Sample
Sample
Sample
Sample
1
1
1
1
1
1
1
1
1
1
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
FK5301
FK5302
FK5303
FK5304
FK5305
FK5401
FK5402
FK5403
FK5404
FK5405
loop,
loop,
loop,
loop,
loop,
loop,
loop,
loop,
loop,
loop,
PEEK, 10 μl
PEEK, 20 μl
PEEK, 50 μl
PEEK, 100 μl
PEEK, 500 μl
stainless steel,
stainless steel,
stainless steel,
stainless steel,
stainless steel,
10 μl
20 μl
50 μl
100 μl
500 μl
HPLC Instruments
➜ Suitable for HPLC vials /
microtiter plates
The ClinLab® AS5000* is a reliable autosampler for
routine analysis, using state-of-the-art injection technology. Samples may be handled both using HPLC
vials and microtiter plates (2 x 96-well and 384well). The sample injection is performed within 1 μl
increments between 0 - 500 μl and with a minimum
carry-over (standard mode: < 0.05 %, with extra
wash: < 0.01%). The instrument control of the
AS5000 can be performed with the chromatography software ClarityTM (see pages 232 - 233).
* identical in construction with Spark Holland, model ALIAS
213
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Degasser
4-Channel-Degasser,
Model DG4000
The ClinLab® 4-Channel-Degasser DG4000 removes
dissolved gases (O2, N2, CO2, ...) in a mild but highly
efficient way. Solvent degassing increases the detection sensitivity by improvement of the base line stability and noise reduction. It prevents the formation of
bubbles in the detector cell, in the pump check valves
or solvent mixing systems and thus ensures a reliable performance of the whole HPLC system. Since
2011 a new instrument series with improved degassing technology and vacuum display is available.
➜ RS232 Connection
➜ Suitable for any conventional HPLC system
Specifications
Principle:
Vacuum degassing technique. The solvent is passed
through a gas permeable membrane tube that is kept
at a constant vacuum level (vacuum chamber).
Vacuum Chamber:
Degassing capacity: 0.5 ppm O2 at 0.5 ml/min
Number of channels: 4
Interior volume
per channel:
8 ml
Maximum flow rate: 10 ml/min
Vacuum pump:
membrane pump
Tube connections:
ID = 1.45 mm; OD = 3 mm
Wetted parts:
PTFE (Teflon) and PEEK
RS232-Connection:
Pressure
output signal:
YES
Error output signal:
YES
Power Supply, Dimensions, Weight:
Power supply:
230 V / 110 V, 50 / 60 Hz
Dimensions:
260 x 510 x 160 mm
(w x d x h)
Weight:
11.5 kg
Ordering Information
Order No.
Description
Quantity
DG4000
ClinLab® 4-Channel-Degasser, Model DG4000, complete
1 pce.
consisting of:
degasser with 4 inlet tubings (incl. fittings and ferrules), user manual
DG4101
Accessories:
Power supply cable
1 pce.
DG4501
Fuse 250 V, T 2.0 A
1 pce.
DG4502
Tubing with fitting and ferrule, 1m, OD: 3 mm
1 pce.
HPLC Instruments
➜ Improved technology
215
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Detectors
Digital Amperometric
EC Detector,
Model EC3000
The EC3000 is a highly sensitive electrochemical
detector for analytical HPLC. The instrument allows
for detection of substances down to the lower picogram range. For the use in routine analysis, the
EC3000 features easy handling and provides a
multitude of functions for automatisation. The basic
equipment of the EC3000 includes the detector cell
EC4000, model Sputnik® (see pages 220 - 221).
➜ Easy handling
➜ Detector cell Sputnik®
included
➜ Cost efficient
Specifications
Principle:
Amperometric detector with three-electrode technique
Detector Cell:
ECD cell EC4000, model Sputnik® (s. p. 220 - 221)
Electronics:
Working potential:
Measurement range:
Auto-Zero range:
Manual offset range:
LCD-display:
± 2.00 V
± (10 pA - 20 μA)
max ± 50 μA
max ± 50 μA
display of settings and
measurement data
Filter:
5 Hz - 0.02 Hz (0.2 - 50 sec)
Detector noise level: < 0.3 pA
Cleaning potential:
± 2.00 V
Cleaning duration:
1 - 100 sec
Delay time before
applying cleaning pot.: 10 - 1500 sec
Cleaning cycle:
every 1st to 10th cycle
Storage capacity for
measurement progr.: 0 - 99
Storage capacity for
cell-cleaning progr.: 0 - 99
Analogue output:
± 1 V per measurem. range
Auto-zero interface: active low, switching contact,
active high, curr./volt. input
Power supply:
input: 115 - 230 V, 50 - 60 Hz
output: 12 V DC, 2.5 A
Dimensions, Weight:
Dimensions:
260 x 510 x 160 mm
(w x d x h)
Weight:
7.6 kg
Ordering Information
Order No.
Description
Quantity
EC3000
ClinLab® Digital Amperometric Detector, Model EC3000, complete
1 pce.
consisting of:
Digital electronic unit, power supply, cell-, signal- and autozero-cable,
complete cell, installed in cell housing, ready-to-use, user manual
EC4000
EC4010
Accessories:
ClinLab® ECD cell, Model Sputnik®, complete
consisting of:
cell, tubings, fittings, glassy carbon working electrode, gaskets,
reference electrode, wrenches, 3 M KCl, manual
ClinLab® Accessory Kit for ECD cell, Model Sputnik®
consisting of:
tubings, fittings, glassy carbon working electrode, gaskets,
reference electrode, wrenches, 3 M KCl, in assortment box
HPLC Instruments
➜ High detection sensitivity
1 pce.
1 pce.
For spareparts of the cell see page 221!
EC3101
EC3102
EC3103
EC3104
EC1103
EC1104
Power supply
Multiple shielded cell-cable for cell EC4000, Model Sputnik®
Autozero-cable with universal-terminals
Autozero-cable with HITACHI-connector
BNC-cable for analog-output with universal-terminals
BNC-cable for analog-output with HITACHI-connector
1
1
1
1
1
1
pce.
pce.
pce.
pce.
pce.
pce.
217
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Detectors
Fixed-WavelengthVIS-Detector (460 nm),
Model FW3000
The FW3000 is designed for a reliable and sensitive
analyte detection at 460 nm. The detector noise
level is at ±5 μAU and thus enables an excellent
detection limit. The FW3000 features easy handling and maintenance at a most favourable price.
The instrument can be controlled via the DataApex
Chromatography Software ClarityTM (see pages
232 - 233).
➜ Easy handling and
maintenance
➜ Cost efficient
Specifications
Principle:
Optics:
Light source:
Wavelength:
Spectral half-width:
Measurement Cell:
Cell volume:
ID of capillary inlet:
Optical path length:
Electronics:
Measurement range:
Single beam principle
Ordering Information
LED
460 nm
12 nm
Description
Quantity
FW3000
ClinLab® Fixed-Wavelength-VIS-Detector (460 nm), Model FW3000, complete
1 pce.
consisting of:
Digital electronic unit, detector cell, test cell, power supply cable,
signal cable (analogue output), autozero-cable, hydrodynamic restrictor,
fuses, adapters, user manual
10 μl
0.2 mm
5 mm
0 - 0.1 AU analogue
0 - 4 AU digital
Detector noise level: ± 0.5 x 10-5 AU
Time constant:
Drift (empty cell):
Analogue output:
Digital output:
Data interface:
Power supply:
Power input:
Miscellaneous:
Wetted parts:
Order No.
fast, middle and slow
2 x 10-4 AU/h
10 V/AU
1 V/AU
RS232
100 / 115 / 230 V, 50 - 60 Hz
80 VA
FW3101
FW3102
FW3103
FW3104
Accessories:
Power supply cable
Signal cable (analogue output)
Autozero-cable with core cable ends
Autozero-cable with Hitachi-connector
1
1
1
1
FW3201
Fuse 230 V, T 1A
1 pce.
FW3301
FW3302
FW3303
FW3304
Detector cell
Test cell
Hydrodynamic restrictor
Lamp replacement
1
1
1
1
pce.
pce.
pce.
pce.
HPLC Instruments
➜ High detection sensitivity
pce.
pce.
pce.
pce.
Vespel, fused silica,
stainless steel
Dimensions, Weight:
Dimensions:
220 x 460 x 180 mm
(w x d x h)
Weight:
7.2 kg
219
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Detectors
Universal Detector
Cell for Amperometric
Detectors,
Model Sputnik®
The detector cell EC4000, model Sputnik® is suitable
for all conventional* amperometric detectors. The cell
enables a high detection sensitivity (see EC3000,
pages 216 - 217) and features optimal handling,
easy maintenance and a most favourable price.
* e.g.: RECIPE, Merck, Antec, Waters, Pharmacia, BioRad
➜ Easy handling and
maintenance
➜ Cost efficient
Specifications
Working Electrode:
Glassy carbon in zirconium oxide
Auxiliary Electrode:
Stainless steel
Reference Electrode:
Ag/AgCl reference electrode with Kel-F housing,
refillable
Diaphragm:
Base-stable zirconium oxide diaphragm
Cell Volume:
1.5 μl with 30 μm spacer
Materials:
Stainless steel, PTFE, PEEK, zirconium oxide,
glassy carbon, Kel-F
Dimensions (w x d x h):
Housing: 120 x 110 x 150 mm
Cell: 40 x 40 x 80 mm
Ordering Information
Order No.
Description
Quantity
EC4000
ClinLab® ECD cell, Model Sputnik®, complete
1 pce.
consisting of:
cell, tubings, fittings, glassy carbon working electrode, gaskets,
reference electrode, wrenches, 3 M KCl, manual
EC4010
EC1107
EC1108
EC1109
EC1113
EC2101
EC2402
EC4201
EC4301
EC4302
EC4303
EC4304
EC4305
EC4501
EC4603
EC4604
EC4605
EC4800
EC2900
Accessories:
ClinLab® Accessory Kit for ECD cell, Model Sputnik®
consisting of:
tubings, fittings, glassy carbon working electrode, gaskets,
reference electrode, wrenches, 3 M KCl, in assortment box
Cell cable for Merck/RECIPE-Detector L-3500A
Cell cable for Antec-Detector
Cell cable for ECD (Waters, Pharmacia)
Adapter Set for BioRad-Detector
Glassy carbon working electrode
Cell gasket 30 μm
Reference electrode, complete
Cell top
Cell body
Compression screw complete with compression disc and contact pin
Wrench for compression screw
Allen wrench 1.5 mm
Tubing set (inlet tubing PEEK 0.25 mm x 100 cm, blue
outlet tubing PEEK 0.5 mm x 100 cm, orange)
Cell housing with mounting device
Mounting device for RECIPE-detector EC3000
Mounting device for ECD (Waters, Pharmacia)
Cell top (exchange)
3 M KCl-Solution
1 pce.
1
1
1
1
1
3
1
1
1
1
1
1
1
HPLC Instruments
➜ High detection sensitivity
pce.
pce.
pce.
pce.
pce.
pcs.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
1 pce.
1 pce.
1 pce.
1 pce.
50 ml
221
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Detectors
UV/VIS-Detector,
Model UV3000
➜ Variable wavelength:
190 - 600 nm
➜ Suitable for any conventional HPLC system
Specifications
Principle:
Variable wavelength UV/VIS-Detector
Optics:
Light source:
Deuterium-Lamp
Wavelength range:
190 -600 nm
Precision:
± 1 nm
Reproducibility:
± 0.5 nm
Spectral half-width:
6 nm
Measurement Cell:
Cell volume:
10 μl
Optical path length: 5 mm
Electronics:
Detector noise:
± 0.5 x 10-5 AU
Time constant:
fast (0.4 sec),
middle (1 sec), slow (5 sec)
Drift (empty cell):
1 x 10-4 AU/h
Output:
1 V / AU (analogue)
Offset / Interface:
± 50 mV / RS232
Miscellaneous:
Wetted parts:
stainless steel,
fused silica, vespel
Power Supply, Dimensions, Weight:
Power supply:
110 / 115 / 230 V, 50 / 60 Hz
Power input:
55 VA
Dimensions:
260 x 490 x 170 mm
(w x d x h)
Weight:
11 kg
Ordering Information
Order No.
Description
Quantity
UV3000
ClinLab® UV/VIS-Detector, Model UV3000, complete
1 pce.
consisting of:
Digital electronic unit, detector cell, test cell, power supply cable,
signal cable (analogue output), autozero cable, hydrodynamic restrictor,
fuses, adapters, fittings, user manual
UV3101
UV3102
UV3103
UV3104
Accessories:
Power supply cable
Signal cable (analogue output)
Autozero-cable
CINCH-connector 2xV (male-male)
1
1
1
1
UV3201
UV3202
UV3203
Fuse 250 V, T 0.8 A
Fuse 250 V, T 1 A
Fuse 250 V, T 2 A
1 pce.
1 pce.
2 pcs.
UV3301
UV3302
UV3303
Detector cell
Test cell
Hydrodynamic restrictor
1 pce.
1 pce.
1 pce.
UV3401
Deuterium lamp
1 pce.
UV3501
UV3502
UV3503
UV3504
UV3505
UV3506
Union, 1/16ʼʼ
Nut, 1/16ʼʼ
Ferrule, 1/16ʼʼ
Fingertight fitting, in one piece, 1/16ʼʼ
PFTE-tubing: OD: 2 mm, ID: 1.5 mm
Luer adapter
2 pcs.
2 pcs.
2 pcs.
2 pcs.
0.5 m
2 pcs.
pce.
pce.
pce.
pce.
HPLC Instruments
➜ High detection sensitivity
The ClinLab® UV/VIS-Detector enables a sensitive
detection (noise level ± 0.5 x 10-5 AU) with a variable wavelength in a range between 190 - 600 nm.
During analysis, the detection wavelength can be
easily switched and thus allows for the determination
at different wavelengths within the same analytical
series. For use in the routine laboratory, the UV3000
features robustness and user-friendliness (e.g. detector diagnosis, easy changing of the detector lamp).
The instrument can be controlled via the DataApex
Chromatography Software ClarityTM (see pages
232 - 233).
223
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HPLC-Pumps
Isocratic Pump,
Model IP3000
The ClinLab® isocratic HPLC pump IP3000 is designed to fulfill the requirements of routine analysis.
The pump ensures a reliable, accurate and stable buffer delivery at any flow rate between 0.01 - 10 ml/min.
The robust instrument allows for a maximum column
backpressure of 400 bar. The IP3000 can be operated with any conventional HPLC system. The instrument can be controlled via the DataApex Chromatography Software ClarityTM (see pages 232 - 233).
➜ Robust design
Specifications
General:
Isocratic dual piston (1/8ʼʼ) HPLC pump with
electronic pulse compensation.
Flow Rates, Pressures:
Flow rates:
0.01 - 10 ml/min
(in 0.01 steps)
-Precision:
±1%
-Accuracy:
±2%
Max. operating
pressure:
400 bar
Precision of pressure
measurement:
±2%
Electronics:
Interface:
RS232
Miscellaneous:
Wetted parts:
stainless steel,
PTFE, PEEK, saphire
Power Supply, Dimensions, Weight:
Power supply:
110 / 115 / 230 V, 50 / 60 Hz
Power input:
30 VA
Dimensions:
260 x 490 x 170 mm
(w x d x h)
Weight:
8.5 kg
Ordering Information
Order No.
Description
Quantity
IP3000
ClinLab® HPLC-Pump, isocratic, Model IP3000, complete
1 pce.
consisting of:
Pump, power supply cable, fuses, inlet tubing incl. fittings,
syringe, waste tubing, user manual
IP3101
IP3102
Accessories:
Power supply cable
RS232 serial cable
1 pce.
1 pce.
IP3201
IP3202
IP3203
Fuse 250 V, T 4 A
Fuse 250 V, T 1 A
Fuse 250 V, T 0.5 A
1 pce.
1 pce.
1 pce.
IP3301
IP3302
IP3310
Inlet tubing, OD: 1/8", ID: 1/16", 1m
Waste tubing with adapter
Plastic syringe 20 ml
1 pce.
1 pce.
1 pce.
IP3401
IP3402
IP3403
IP3404
Piston
Piston seal
Piston rear washing set
Washing seal
1
1
1
1
IP3503
Inlet/outlet valve cartridge
1 pce.
FK5000
PEEK Starterkit
contents:
Fingertight fitting, in one piece, 1/16"
Fingertight fitting, in one piece, narrow head, 1/16"
Hex head nut, 1/16"
Double ferrule, 1/16"
Union, 1/16"
Tubing, OD: 1.59 mm (=1/16"), ID: 0.25 mm, blue
Tubing, OD: 1.59 mm (=1/16"), ID: 0.50 mm, orange
ClinLab® Plus, cutter and flange tool
1 pce.
5
5
5
5
1
3
3
1
HPLC Instruments
➜ Safe, accurate and stable
buffer delivery
pce.
pce.
set
pce.
pcs.
pcs.
pcs.
pcs.
pce.
m
m
pce.
225
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HPLC-Pumps
Gradient Pump,
Model GP3000
The ClinLab® GP3000 is a ternary HPLC gradient
pump designed to meet the requirements in laboratory analysis. The pump provides the selected
eluent composition, either isocratic or as ternary
gradient. In routine analysis, the GP3000 facilitates
storage of up to 100 different gradient programs, the
corresponding data files can be imported via RS232
interface. The GP3000 can be controlled via the
DataApex Chromatography Software ClarityTM (see
pages 232 - 233).
➜ Safe, accurate and stable
buffer delivery
➜ Robust design
Specifications
General:
Dual piston (1/8ʼʼ), ternary low pressure
gradient HPLC pump.
Flow Rates, Pressures:
Flow rates
(in 0.01 steps):
gradient mode:
0.01 - 3 ml/min
isocratic mode:
0.01 - 10 ml/min
-Precision:
±1%
-Accuracy:
±2%
Max. op. pressure:
400 bar
Gradient Elution:
Number of valves:
3 (A, B, C)
Setting of components
A, B, C:
0 - 100 % (in 1 % steps)
Gradient programs: up to 100
Gradient sections
per program:
up to 50
Electronics:
Interface:
RS232
Miscellaneous:
Wetted parts:
stainless steel,
PTFE, PEEK, saphire
Power Supply, Dimensions, Weight:
Power supply:
110 / 115 / 230 V, 50 / 60 Hz
Power input:
50 VA
Dimensions:
260 x 490 x 170 mm
(w x d x h)
Weight:
9 kg
Ordering Information
Order No.
Description
Quantity
GP3000
ClinLab® Gradient HPLC-Pump, Model GP3000, complete
1 pce.
consisting of:
Pump, power supply cable, fuses, inlet tubing incl. fittings,
syringe, waste tubing, start-signal cable, user manual
GP3101
GP3102
Accessories:
Power supply cable
RS232 serial cable
1 pce.
1 pce.
GP3201
GP3202
GP3203
Fuse 250 V, T 4 A
Fuse 250 V, T 1 A
Fuse 250 V, T 0.5 A
1 pce.
1 pce.
1 pce.
GP3301
GP3302
GP3310
Inlet tubing, OD: 1/8", ID: 1/16", 1m
Waste tubing with adapter
Plastic syringe 20 ml
1 pce.
1 pce.
1 pce.
GP3401
GP3402
GP3403
GP3404
Piston
Piston seal
Piston rear washing set
Washing seal
1
1
1
1
GP3503
Inlet/outlet valve cartridge
1 pce.
FK5000
PEEK Starterkit
contents:
Fingertight fitting, in one piece, 1/16"
Fingertight fitting, in one piece, narrow head, 1/16"
Hex head nut, 1/16"
Double ferrule, 1/16"
Union, 1/16"
Tubing, OD: 1.59 mm (=1/16"), ID: 0.25 mm, blue
Tubing, OD: 1.59 mm (=1/16"), ID: 0.50 mm, orange
ClinLab® Plus, cutter and flange tool
1 pce.
5
5
5
5
1
3
3
1
HPLC Instruments
➜ Precise ternary gradients
pce.
pce.
set
pce.
pcs.
pcs.
pcs.
pcs.
pce.
m
m
pce.
227
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HPLC-Thermostat
HPLC-Thermostat,
Model HT4000
The ClinLab® HPLC-Thermostat HT4000 establishes
the basis for optimised and standardised detection.
All HPLC components which influence the chromatographic separation, from injection valve to ECdetector cell, are temperature controlled (10 - 60 °C).
The thermostat chamber provides room for several
columns as well as for the detector cell EC4000
(see pages 220 - 221). The HT4000 can be controlled via the DataApex Chromatography Software
ClarityTM (see pages 232 - 233).
➜ Detector cell EC4000
installable
➜ Cost efficient
Specifications
Principle:
Microprocessor-controlled peltier heating/cooling.
Forced air concept for homogenous temperature
distribution and quick temperature adjustment.
Thermostat Chamber:
Temperature control range:
10 °C - 60 °C
Temperature control accuracy: ± 0.5 °C
Temperature constancy:
± 0.15 °C
Safety in Operation:
The HT4000 is equipped with a gas sensor and an
automatic shut-down in case of failure.
Power Supply, Dimensions:
Power supply:
100 - 240 V, 50 - 60 Hz
Power input:
190 VA
Housing dimensions: 260 x 490 x 220 mm
(w x d x h)
Thermostat chamber
dimensions:
100 x 440 x 120 mm
(w x d x h)
Ordering Information
Order No.
Description
Quantity
HT4000
ClinLab® HPLC-Thermostat, Model HT4000, complete
1 pce.
consisting of:
HPLC-Thermostat, power supply cable, fuse, mounting device for ClinLab® ECD cell,
model Sputnik®, user manual
HT4104
Accessories:
Power supply cable
RS232 Serial cable
Multiple shielded cell-cable for cell EC4000,
model Sputnik® and EC-detector, modell EC3000
Cell cable for cell EC4000, model Sputnik® and EC-detector, model L-3500A
1 pce.
HT4201
HT4202
Fuse 250 V, 3.15 A
Fuse 250 V, 16 A
1 pce.
1 pce.
HT4501
Waste tubing
1 pce.
FK1000
FK1005
Manual injection valve Rheodyne 7725i, complete
Manual injection valve Rheodyne 9725i (PEEK), complete
1 pce.
1 pce.
FK5101
FK5102
Fingertight fitting, in one piece, 1/16"
Fingertight fitting, in one piece, narrow head, 1/16"
5 pcs.
5 pcs.
FK5201
FK5202
FK5203
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.17 mm, yellow
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.25 mm, blue
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.50 mm, orange
3m
3m
3m
HT4101
HT4102
HT4103
1 pce.
1 pce.
1 pce.
HPLC Instruments
➜ Temperature control from
10 - 60 °C
229
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HPLC-Thermostat
Column Heater,
Model CH3000
The ClinLab® Column Heater, Model CH3000, is
designed for a thermostatisation at temperatures
between ambient temperature and 100 °C and provides space for two HPLC columns. The instrument
can be controlled via the DataApex Chromatography Software ClarityTM (see pages 232 - 233).
➜ RS232 interface
➜ Cost efficient
Ordering Information
Order No.
Description
Quantity
CH3000
ClinLab® Column Heater, Model CH3000, complete
1 pce.
consisting of:
Column heater, power supply cable, fuses, user manual
CH3101
CH3102
Accessories:
Power supply cable
RS232 Serial cable
1 pce.
1 pce.
CH3201
CH3202
Fuse 250 V, T 1.25 A
Fuse 250 V, T 2.5 A
1 pce.
1 pce.
FK5101
FK5102
Fingertight fitting, in one piece, 1/16"
Fingertight fitting, in one piece, narrow head, 1/16"
5 pcs.
5 pcs.
FK5201
FK5202
FK5203
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.17 mm, yellow
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.25 mm, blue
Tubing, OD: 1.59 mm (= 1/16"), ID: 0.50 mm, orange
3m
3m
3m
HPLC Instruments
➜ Temperature control
from ambient temperature
to 100 °C
Specifications
Principle:
Microprocessor-controlled heating.
Heating Chamber:
Temperature control range:
from the actual
ambient temperature to 99.9 °C
Temperature control accuracy: ± 0.5 °C
Temperature constancy:
± 0.1 °C
Heating rate:
5 °C/min
Power Supply, Dimensions, Weight:
Power supply:
100 / 115 / 230 V ± 10 %,
50 / 60 Hz
Weight:
8.5 kg
Housing dimensions: 260 x 490 x 160 mm
(w x d x h)
Heating block:
34 x 310 x 27 mm
(w x d x h)
231
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Chromatography Software
Several of our ClinLab® HPLC Instruments can be used with the chromatography software Clarity™
from DataApex.
Clarity™ is suitable for the control of the HPLC-system, for data acquisition, and data evaluation.
RECIPE is an authorised Clarity™-Trainingscenter in Germany.
We provide a 1 day intensive course (see order no. SW1900) were
we give all essential knowledge for software handling.
Ordering Information
Order No.
Description
Quantity
SW1000
Software:
Software-Packet Clarity™
1 pce.
consisting of:
basic software module, 2 control modules, A/D-converter (2-channel) (for data aquisition
and chromatography evaluation*, as well as for controlling an HPLC-system)
Basic Software Module Clarity™
(for data aquisition and chromatography evaluation*)
1 pce.
SW1201
SW1202
Software-extension modules:
Module for an additional HPLC-system
Module for system suitability tests
1 pce.
1 pce.
SW1301
SW1302
Control modules:
Control module for HPLC-instruments like pump, detector, etc.
Control module for Autosampler
1 pce.
1 pce.
SW1604
SW1605
SW1612
SW1613
Hardware:
A/D-converter (USB), 2-channel, incl. cable
A/D-converter (USB), 4-channel, incl. cable
USB-RS232 Adapter
Multicom-Converter (1 x USB to 6 x RS232)
1
1
1
1
SW1701
RS232 Serial cable
1 pce.
SW1900
Clarity Training
1 day course
pce.
pce.
pce.
pce.
HPLC Instruments
SW1100
* For controlling HPLC-instruments, corresponding RS232 serial cables and RS232 serial ports, as well as free
USB ports are required in the PC; please note hardware-requirements!
Hardware-Requirements
with operating system: Windows XP/2000:
minimum: Pentium III/700 MHz, 256 MB RAM
recommended: Pentium 4/2 GHz, 512 MB RAM
with operating system: Windows Vista, Windows 7 / 8:
identical with requirements for operating system
Monitor:
minimum: resolution 1024 x 768, 64K
recommended: resolution 1280 x 1024, 64K
free USB ports, CD-ROM drive
Clarity™ is a registered trademark of DataApex
232
233
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HPLC Accessories
ClinRep® Reagents
for Chromatography
. . . . . . . . 236
HPLC Accessories
ClinLab® HPLC
Accessories . . . . . . . . . . . . . . 237 - 239
235
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ClinRep® Reagents for Chromatography
ClinLab® HPLC Accessories
Reagents for Passivation
Tubings, Fittings and Helpful Tools
Order No.
Description
Quantity
Order No.
Description
Quantity
RC2000
RC2001
RC2002
Nitric acid halfconcentrated (32.5 %)
2-Propanol
Sodium hypochlorite solution (5 %)
200 ml
200 ml
12 ml
FK5000
PEEK Starterkit
➜ includes all order nos. marked with (*)
1 pce.
FK5201
FK5202
FK5203
Colour-coded tubings:
PEEK tubing, yellow, OD: 1.59 mm (=1/16ʼʼ), ID: 0.17 mm
* PEEK tubing, blue, OD: 1.59 mm (=1/16ʼʼ), ID: 0.25 mm
* PEEK tubing, orange, OD: 1.59 mm (=1/16ʼʼ), ID: 0.50 mm
3m
3m
3m
FK5101
FK5102
FK5110
FK5111
FK5120
FK5121
FK5122
FK5131
FK5132
PEEK fittings:
* Fingertight fitting, in one piece, for tubings with OD: 1/16ʼʼ
* Fingertight fitting, in one piece, narrow head, for tubings with OD: 1/16ʼʼ
* Hex head nut, for tubings with OD: 1/16ʼʼ
* Double ferrule, for tubings with OD: 1/16ʼʼ
* Union, for tubings with OD: 1/16ʼʼ
T-Union, for tubings with OD: 1/16ʼʼ
Cross-Union, for tubings with OD: 1/16ʼʼ
Fitting flangeless 1/8ʼʼ, 1/4ʼʼ-28
Ferrule 1/8ʼʼ for order no. FK5131
5
5
5
5
1
1
1
5
5
Solvents for Chromatography
Order No.
Description
Quantity
RC1000
RC1001
RC1050
Acetonitrile
Methanol
HPLC water
1000 ml
1000 ml
1000 ml
Sample Preparation Columns
The following products are permanently available from stock*:
FK5902
RC5000
RC5050
Column
Size
Amount
1 ml
1 ml
100 mg
100 mg
RC5060
1 ml
100 mg
RC5055
1 ml
200 mg
RC5010
RC5500
RC5200
RC5210
RC5220
RC5201
RC5211
RC5230
1
1
3
3
3
3
3
3
ml
ml
ml
ml
ml
ml
ml
ml
50 mg
empty
200 mg
200 mg
200 mg
500 mg
500 mg
500 mg
RC5510
RC6000
RC5100
RC5110
3 ml
8 ml
16 ml
16 ml
empty
1000 mg
1000 mg
1000 mg
RC5105
RC5120
RC5550
16 ml
16 ml
16 ml
500 mg
500 mg
empty
Filling Material
Properties
Quantity
RP18e
strong anion exchanger
(Cl- form capacity: at least 200 μeq/g)
weak cation exchanger
(H+ form capacity: at least 10 meq/g)
strong anion exchanger, suspension
(Cl- form capacity: at least 600 μeq/g)
RP8
100 pcs.
RP8
RP18
RP18e
RP8
RP18
strong anion exchanger
(Cl- form capacity: at least 200 μeq/g)
silica 60
RP18
strong anion exchanger, suspension
(Cl- form capacity: at least 600 μeq/g)
RP18
silica 60
100 pcs.
FK5890
FK5891
FK5901
Tubing cutter and accessories:
Tubing cutter (for PEEK capillaries)
Replacement blades for tubing cutter
Tubing cutter (for stainless steel capillaries)
1 pce.
1 pce.
1 pce.
100 pcs.
100 pcs.
100 pcs.
50 pcs.
50 pcs.
50 pcs.
50 pcs.
50 pcs.
50 pcs.
50
50
50
50
pcs.
pcs.
pcs.
pcs.
50
50
50
50
pcs.
pcs.
pcs.
pcs.
Accessories for Autosampler and Sample Vials
Order No.
Description
Quantity
FK6200
FK6201
FK6202
FK6203
FK6401
FK6402
Sample vials:
with screw thread, clear glass, 1.5 ml
with screw thread, brown glass, 1.5 ml
with Luer-adapter and screw thread, clear glass, 1.5 ml
with Luer-adapter and screw thread, brown glass, 1.5 ml
clear glass, 4 ml
PP, without cap, 1.5 ml
100
100
100
100
100
100
FK6002
FK6100
FK6210
FK6211
FK6212
Micro sample vials:
PE, with cap, 250 μl
PP, conical with crimp top, 300 μl
clear glass, 100 μl, for order nos. FK6200 and FK6201
PE, without cap, 200 μl, for order nos. FK6200 and FK6201
clear glass, 200 μl, for order nos. FK6200 and FK6201
1000 pcs.
1000 pcs.
100 pcs.
100 pcs.
100 pcs.
FK6001
FK6220
FK6221
FK6230
FK6240
FK6250
Vial accessories:
Rack adapter for micro sample vials
Screw cap with hole, for order nos. FK6200, FK6201, FK6202 and FK6203
Screw cap without hole, for order nos. FK6200, FK6201, FK6202 and FK6203
PTFE-septum, for order no. FK6220
Spring for micro sample vial, for order no. FK6210
Spring for micro sample vial, for order no. FK6212
50 pcs.
100 pcs.
100 pcs.
100 pcs.
100 pcs.
100 pcs.
FK6500
FK6510
FK6511
FK6512
96-Well plates:
Protective sheets for 96-well plate (aluminium foil, 80 x 140 mm)
96-well plates (370 μl)
96-well plates (1200 μl)
96-well plates (500 μl)
100 pcs.
5 pcs.
5 pcs.
8 pcs.
* Special designed products on request!
236
ClinLab® Plus:
* Cutter and flange tool for flanging Teflon and PEEK tubings (1/8ʼʼ and 1/16ʼʼ),
1 pce.
consisting of:
1 tubing cutter incl. replacement blade, 1 tubing holder, 1 flange-roll, 1 set of flange disks
pcs.
pcs.
pcs.
pcs.
pcs.
pcs.
HPLC Accessories
Order No.
pcs.
pcs.
pcs.
pcs.
pce.
pce.
pce.
pcs.
pcs.
237
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ClinLab® HPLC Accessories
ClinLab® HPLC Accessories
Injection Valves, Switching Valves, Sample Loops
Accessories for the HPLC-System
Order No.
Description
Quantity
Order No.
FK1000
FK1001
FK1005
Manual injection valves:
Rheodyne 7725i, complete
Rheodyne 7125 (serviced)
Rheodyne 9725i (PEEK), complete
1 pce.
1 pce.
1 pce.
FK2000
FK2001
ClinLab® Peristaltic pump:
Peristaltic pump (flow rate: 0.2 ml/min) incl. 2 tubings with fitting-adapter
(TYGON®, ID 0.38 mm)
Replacement tubing with fitting-adapter (TYGON®, ID 0.38 mm) for peristaltic pump
FK1102
FK1103
Column switching valves:
Switching Valve, Sykam, 6-port / 3-channel, incl. electric valve drive, PEEK version
Switching Valve, Sykam, 6-port / 3-channel, incl. electric valve drive, stainless steel version
1 pce.
1 pce.
FK2500
FK2501
ClinLab® Back Pressure Regulator:
Back pressure regulator, stainless steel version, 34 bar
Replacement cartridge gold coat, 34 bar
FK5301
FK5302
FK5303
FK5304
FK5305
PEEK sample loops:
10 μl
20 μl
50 μl
100 μl
500 μl
1
1
1
1
1
Accessories for columns
FK5401
FK5402
FK5403
FK5404
FK5405
Stainless steel sample loops:
10 μl
20 μl
50 μl
100 μl
500 μl
1
1
1
1
1
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
pce.
Order No.
Description
FK4000
ClinRep® Column Rack:
Column rack for 20 columns
1 pce.
FK3000
ClinLab® Incubator:
Thermocult Incubator (37 °C)
1 pce.
FK1050
FK1052
FK1060
Hamilton Injection syringes:
25 μl with replaceable needle
100 μl with replaceable needle
Hamilton replacement needle for injection syringes,
order no.: FK1050 and order no.: FK1052
Quantity
1 pce.
2 pcs.
1 pce.
1 pce.
Order No.
Description
Quantity
FK5801
FK5802
FK5810
FK5820
FK5821
Prefilters and accessories:
PEEK prefilter holder
Replacement filter for PEEK prefilter holder
PEEK capillary connector (connection of prefilter and column)
Stainless steel prefilter holder
Replacement filter for stainless steel prefilter holder
1 pce.
5 pcs.
1 pce.
1 pce.
10 pcs.
FK7200
FK7201
Accessory for LichroCART® stainless steel cartridges:
manu-CART® cartridgeholder for ClinRep® Analytical Columns
(stainless steel cartridges)
Seal elements (PTFE-rings)
Tool for seal elements
10 pcs.
1 pce.
FK7300
FK7310
FK7320
FK7330
FK7340
FK7350
FK7360
FK7400
HPLC-cartridge column with accessories:
HPLC-cartridge column, empty, 20 x 4 mm, complete with endfittings
HPLC-cartridge column, empty, 20 x 4 mm
Column holder for order no. FK7310
Endfittings
Sealings and sieves
Endstoppers
Cartridge caps for order no. FK7310
Inline-Filter (stainless steel sieve, free of dead volume)
1
1
1
2
4
2
2
1
FK7000
Accessories for Sample Preparation
Description
1 set
Quantity
1 pce.
1 pce.
1 pce.
Reagent tube:
100 x 16 mm, with screw cap and o-ring, PP, autoclavable up to 121 °C
50 pcs.
FK5830
Syringe filter:
with Luer connector, Polyamide, 0.22 μm
100 pcs.
HPLC Accessories
FK6300
pce.
pce.
pce.
pcs.
pcs. each
pcs.
pcs.
pce.
238
239
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Index
Acetylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Bromide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Diazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
HbC (Hemoglobin C) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
6-Acetylmorphine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Bupropion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Dimethylarsinic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
HbD (Hemoglobin D) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
Acylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Butoxy acetic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Diphenylhydantoin (Phenytoin) . . . . . . . . 92 - 97, 146, 173, 202
HbE (Hemoglobin E) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
5-ALA (5-Aminolevulinic acid) . . . . . . . . . . . . . 54 - 55, 60 - 61,
Butyrylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Disialotransferrin . . . . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
HbF (Hemoglobin F) . . . . . . . . . . . . . . . . . . 148, 177, 206 - 207
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 168 - 169, 196, 198
Cadmium . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Dodecanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
HbS (Hemoglobin S) . . . . . . . . . . . . . . . . . . . . . . . . . . 148, 207
Alanine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Caffeine . . . . . . . . . . . . . . . . . . . . . . . . . 90 - 91, 146, 170, 199
Dopamine . . . . . . . . . . . . . . . . 22 - 31, 147, 168, 171, 196, 199
Hemoglobin A0 (HbA0) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
Alcoholism . . . . . . . . . . . . . . . . . . . . . . . . . . . 12 - 17, 120 - 121
Carbamazepine . . . . . . . . . . . . . . . 92 - 97, 146, 149, 173, 202
Doxepin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Hemoglobin A1 (HbA1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Alprazolam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Carbamazepine-epoxide . . . . . . . . . . . . . 92 - 97, 146, 173, 202
Doxylamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 149
Hemoglobin A1c (HbA1c) . . . . . . . . . . . . . . . . 48 - 51, 148, 176
Alprazolam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Carnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Drugfree . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
Hemoglobin A2 (HbA2) . . . . . . . . . . . . . . . . . . . . 148, 177, 207
Aluminium . . . . . . . . . . . . . . . . . . .169, 172, 175, 198, 201, 205
β-Carotene . . . . . . . . . . . . . . . . . . . . . . . 64 - 65, 147, 171, 200
Duloxetine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Hemoglobin C (HbC) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
Amino Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Catecholamines . . . . . . . . . . . 22 - 31, 147, 168, 171, 196, 199
EDDP . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Hemoglobin D (HbD) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
α-Aminobutyric acid . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
CDT (carbohydrate
Efavirenz . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Hemoglobin E (HbE) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
7-Aminoclonazepam . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
deficiency transferrin) . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Efavirenz-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Hemoglobin F (HbF) . . . . . . . . . . . . . . . . . . 148, 177, 206 - 207
7-Aminoclonazepam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Chlordiazepoxide . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Epinephrine . . . . . . . . . . . . . . 22 - 31, 147, 168, 171, 196, 199
Hemoglobin S (HbS) . . . . . . . . . . . . . . . . . . . . . . . . . . 148, 207
7-Aminoflunitrazepam . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Chlordiazepoxide-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Escitalopram . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Hemoglobin, free . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
7-Aminoflunitrazepam-d7 . . . . . . . . . . . . . . . . . . . . . . . . . . . .140
Chromium . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Eslicarbazepine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 94 - 97
Heptacarboxyporphyrin I . . . . . . . . . . . . 60 - 61, 150, 169, 198
7-Aminonitrazepam . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
cis-Cl2-CA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Estazolam . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Hexacarboxyporphyrin I . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Amiodarone . . . . . . . . . . . . . . . . . . . . . . 88 - 89, 146, 172, 201
Citalopram . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Estazolam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Hexacarboxyporphyrin lab + lac . . . . . . . . . . . 60 - 61, 150, 198
Amisulpride . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Citrulline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Ethosuximide . . . . . . . . . . . . . . . . . . . . . 92 - 97, 146, 173, 202
Hexadecanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Amitriptyline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Clobazam . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Ethoxy acetic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Hexanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Amphetamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Clomipramine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Ethylglucuronide . . . . . 120 - 121, 138, 140, 168, 174, 197, 203
Hexasialotransferrin . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Amprenavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Clonazepam . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Ethylglucuronide-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 140
5-HIAA (5-Hydroxyindoleacetic acid) . . . . . . . . . . .42 - 47, 151,
Amprenavir-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Clonazepam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Ethylsulfate . . . . . . . . . 120 - 121, 138, 140, 168, 174, 197, 203
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 196
Antiarrhythmics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 88 - 89
Clozapine . . . . . . . . . . . . . . 104 - 105, 147, 170, 175, 199, 204
Ethylsulfate-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 140
Hippuric acid . . . . . . . . . . . . . . . . . . . . 110 - 111, 148, 169, 197
Antiepileptics . . . . . . . . . . . . 92 - 101, 146, 149, 171, 173, 174
Cobalt . . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Etravirine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Histidine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200, 202, 204
Codeine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Etravirine-d8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Homocysteine . . . . . . . . . . . . . . . 56 - 57, 126 - 129, 140, 148,
Antimony . . . . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
Coenzyme Q10 (Ubiquinone) . . . . . . . . . 66 - 67, 148, 171, 200
Everolimus . . . . . . . . . . . . . . . . . . . . . 122 - 125, 139, 177, 207
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171, 174, 177, 200, 207
Antiretrovirals . . . . . . . . . . . . . . . . . . . . . . . . 138, 140, 173, 202
Copper . . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Everolimus-13C2d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
Homocystine-d8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Arginine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Coproporphyrin I . . . . . . . . . . . . . . . . . . . 60 - 61, 150, 169, 198
Everolimus-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
Homovanillic acid (HVA) . . . . . . . . . . . . . 42 - 47, 151, 170, 196
Aripiprazole . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Coproporphyrin III . . . . . . . . . . . . . . . . . . 60 - 61, 150, 169, 198
FAD (Flavin adenine dinucleotide) . . . . . . . . . . 76 - 77, 80 - 81,
HPLC-Autosampler . . . . . . . . . . . . . . . . . . . . . . . . . . . 212 - 213
Arsenic . . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Cotinine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150, 177, 207
HPLC-Degasser . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 214 - 215
Arsenic III . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
Cotinine-d3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Felbamate . . . . . . . . . . . . . . . . . . . . . . . . 94 - 97, 146, 173, 202
HPLC-Detector . . . . . . . . . . . . . . . . . . . . . 216 - 219, 222 - 223
Arsenic Species . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
o-Cresol . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 - 109, 169, 198
Flavin adenine dinucleotide (FAD) . . . . . . . . . . 76 - 77, 80 - 81,
HPLC-EC-Detector Cell . . . . . . . . . . . . . . . . . . . . . . . 220 - 221
Arsenic V . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
CSF/Serum Quotient . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 203
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150, 177, 207
HPLC-Pump . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 224 - 227
Arsenobetaine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
Cyclosporine A . . . . . . . . . . . . . . . . . . 122 - 125, 139, 177, 207
Flavinemononucleotide (FMN) . . . . . . . . . 76 - 77, 80 - 81, 150
HPLC-Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 232 - 233
Ascomycin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 140
Cyclosporine A-d12 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
Flunitrazepam . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
HPLC-Thermostat . . . . . . . . . . . . . . . . . . . . . . . . . . . . 228 - 231
Ascorbic Acid (Vitamin C) . . . . . . . . . . . . . . . . 70 - 71, 151, 205
Cyclosporine D . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
Flunitrazepam-d7 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
HVA (Homovanillic acid) . . . . . . . . . . . . . 42 - 47, 151, 170, 196
Asialotransferrin . . . . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Cysteine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 - 57, 148
Fluoride . . . . . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
α-Hydroxyalprazolam . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Asparagine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Cysteinglycine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
Fluoxetine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
α-Hydroxyalprazolam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Aspartic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Darunavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Flurazepam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
10-Hydroxy-Carbamazepine . . . . . . . . . 92 - 97, 146, 171, 173,
Atazanavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Darunavir-d9 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Fluvoxamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 202, 204
Atazanavir-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Decanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
FMN (Flavinemononucleotide) . . . . . . . . . 76 - 77, 80 - 81, 150
3'-Hydroxycotinine . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Barium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Delavirdine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Free hemoglobin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Hydroxycotinine-d3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Basic Drugs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 - 19
Demoxepam . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Gabapentine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Hydroxy-Itraconazole . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 199
Benzodiazepines . . . . . . . . . . . . 130 - 131, 138, 140, 174, 203
Desalkylflurazepam . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Glutamic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
5-Hydroxy-MEHP [Mono-(2-ethyl-
Beryllium . . . . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
Desethylamiodarone . . . . . . . . . . . . . . . . . . . . . . 146, 172, 201
Glutamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
5-hydroxyhexyl) phthalate] . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Biogenic Amines . . . . . . . . . 22 - 31, 34 - 37, 44 - 47, 147, 168,
Desipramine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Glutarylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
α-Hydroxymidazolam . . . . . . . . . . . . . 130 - 131, 138, 174, 203
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 171, 196, 199
Desmethylclozapine (Norclozapine) . . . . . 104 - 105, 147, 149,
Glycine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
α-Hydroxymidazolam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Bismuth . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172, 175, 201, 205
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 175, 199, 204
Gold . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172, 175, 201, 205
Hydroxyproline . . . . . . . . . . . . . . . . . . . . 58 - 59, 148, 168, 196
Bisphenol A . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169
Desmethylfluoxetine . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Haloperidol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
1-Hydroxypyrene . . . . . . . . . . . . . . . . . . . . . 114 - 115, 169, 198
Br2-CA [3-(2,2-Dibromovinyl)-
N-Desmethylmethsuximide (NDMS) . . . . 92 - 97, 146, 173, 202
HbA0 (Hemoglobin A0) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 148
9-Hydroxy-Risperidone
2,2-dimethylcyclopropan-
Desmethylolanzapine . . . . . . . . . . . . . 104 - 105, 147, 170, 199
HbA1 (Hemoglobin A1) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
(Paliperidone) . . . . . . . . . . . . . . . 104 - 105, 147, 170, 175, 199
1-carboxylic acid] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
O-Desmethylvenlafaxine . . . . . . . . . . . . . . . . . . . . . . . 175, 204
HbA1c (Hemoglobin A1c) . . . . . . . . . . . . . . . . 48 - 51, 148, 176
α-Hydroxytriazolam . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Bromazepam . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Diazepam . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
HbA2 (Hemoglobin A2) . . . . . . . . . . . . . . . . . . . . 148, 177, 207
α-Hydroxytriazolam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:35 Seite 242
Index
25-Hydroxy-Vitamin D2 . . . . . . . . . . . . . . . . 82 - 85, 134 - 135,
Methylenedianiline . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 175, 199
Sertraline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 151, 176, 205
N-Methylformamide . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Palladium . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Silver . . . . . . . . . . . . . . . . . . . . . . 172, 175, 177, 201, 205, 207
25-Hydroxy-Vitamin D3 . . . . . . . . . . . . . . . . 82 - 85, 134 - 135,
m/p-Methyl-hippruric acid . . . . . . . . . . . . . . 169, 197, 110 - 111
Paroxetine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Sirolimus . . . . . . . . . . . . . . . . . . . . . . . 122 - 125, 139, 177, 207
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 151, 176, 205
o-Methyl-hippuric acid . . . . . . . . . . . . . . . . . 169, 197, 110 - 111
3-PBA (3-Phenoxybenzoic acid) . . . . . . . . . . . . . . . . . . . . . 197
Sirolimus-13Cd3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
3-epi-25-Hydroxy-Vitamin D3 . . . . . . . . . . . . . . . . . . . . . . . . 139
Methylmalonic acid . . . . . . . . . . . . . . . 132 - 133, 139, 174, 204
PBG (Porphobilinogen) . . . . . . . . . . 54 - 55, 60 - 61, 168 - 169,
Stiripentol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
25-Hydroxy-Vitamin D3-d6 . . . . . . . . . . . . . . . . . . . . . . 139, 176
Methylmalonic acid-d3 . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196, 198
Sulthiame . . . . . . . . . . . . 92 - 99, 146, 149, 171, 173, 200, 202
25-Hydroxy-Vitamin D3-d7 . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Methylmalonylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
PCP (Pentachlorophenol) . . . . . . . . . . . . . . . . . . . . . . 169, 198
Tacrolimus . . . . . . . . . . . . . . . . . . . . . . 122 - 125, 139, 177, 207
Imipramine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Methylxanthines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 90 - 91
PEMA (Phenylethyl-malonamide) . . . . . . 92 - 93, 146, 173, 202
Tacrolimus-13Cd2 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 141
Immunosuppressants . . . . . . . . . . . . . . . . 102 - 103, 122 - 125,
Mianserin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Pentacarboxyporphyrin I . . . . . . . . . . . . . 60 - 61, 150, 169, 198
Taurine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Temazepam . . . . . . . . . . . . . . . . 130 - 131, 138, 149, 174, 203
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 139, 140, 177, 207
MiBP [Mono-iso-butylphthalate] . . . . . . . . . . . . . . . . . . . . . . 197
Pentachlorophenol (PCP) . . . . . . . . . . . . . . . . . . . . . . 169, 198
Indinavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Midazolam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Pentasialotransferrin . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Temazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Indinavir-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Midazolam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Perampanel . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Tetradecanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Iodide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 172, 198, 201
Mirtazapine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Perazine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Tetrasialotransferrin . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Iron . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 175, 198, 205
MnBP [Mono-n-butylphthalate] . . . . . . . . . . . . . . . . . . . . . . . 197
Phenobarbital . . . . . . . . . . . . . . . . . . . . . 92 - 97, 146, 173, 202
Tetrazepam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Isoleucine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Molybdenum . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
Phenol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 108 - 109, 169, 198
Thallium . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Isovalerylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Monomethylarsonic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196
3-Phenoxybenzoic acid (3-PBA) . . . . . . . . . . . . . . . . . . . . . 197
Theobromine . . . . . . . . . . . . . . . . . . . . . . 90 - 91, 146, 170, 199
Itraconazole . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 199
Monosialotransferrin . . . . . . . . . . . . . . . . . . . . . . . . 12 - 17, 147
Phenylalanine . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Theophylline . . . . . . . . . . . . . . . . . . . . . . 90 - 91, 146, 170, 199
Keppra® (Levetiracetam) . . . . . . . . . 100 - 101, 149, 173 - 174,
Morphine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Phenylethyl-malonamide (PEMA) . . . . . . 92 - 93, 146, 173, 202
Thiamine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202, 204
Muconic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 - 113
Phenylglyoxylic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Thiaminemonophosphate (TMP) . . . . . . . . . . . . . . . . . . . . . 150
Lacosamide . . . . . . . . . . . . . . . . . . . . . . 94 - 97, 146, 173, 202
t,t-Muconic Acid . . . . . . . . . . . . . . . . . . . . . . . . . . 149, 169, 197
S-Phenylmercapturic acid . . . . . . . . . . . . . . . . . . . . . . 169, 197
Thiaminepyrophosphate (TPP) . . . . . . . . 74 - 75, 80 - 81, 150,
Lamotrigine . . . . . . . . . . . . . . 92 - 99, 146, 149, 171, 173, 175,
Mycophenolic acid . . . . . . . . . . . . . . . 102 - 103, 149, 172, 201
Phenytoin (Diphenylhydantoin) . . . . . . . . 92 - 97, 146, 173, 202
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177, 207
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 200, 202, 204
1-Naphthol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 198
Phosphoserine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Threonine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Lead . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 177, 198, 207
2-Naphthol . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 198
Platinum . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Tiagabine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Leucine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
NDMS (N-Desmethylmethsuximide) . . . . 92 - 97, 146, 173, 202
PLP (Pyridoxal-5-phosphate) . . . . . . . . 78 - 81, 150, 176 - 177,
Tilidine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Levetiracetam (Keppra®) . . . . . . . . . 100 - 101, 149, 173 - 174,
Nelfinavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 - 207
Tin . . . . . . . . . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 202, 204
Nelfinavir-d3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Porphobilinogen (PBG) . . . . . . . . . . 54 - 55, 60 - 61, 168, 169,
Tipranavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Lithium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 172, 175, 201, 205
Neuroleptics . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104 - 105, 147
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 196, 198
Tipranavir-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Lopinavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Nevirapine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Porphyrins . . . . . . . . . . . . . . . . . 54 - 55, 60 - 63, 150, 196, 198
TMP (Thiaminemonophosphate) . . . . . . . . . . . . . . . . . . . . . 150
Lopinavir-d8 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Nevirapine-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Potassium . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177, 207
α-Tocopherol (Vitamin E) . . . . . . . . . . . . 72 - 73, 150, 176, 206
Lorazepam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Nickel . . . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Prazepam . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Topiramate . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Lorazepam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Nicotine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Prazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Total porphyrins . . . . . . . . . . . . . . . . . . . . . . . 62 - 63, 196, 198
Lormetazepam . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Nicotine-d3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Pregabaline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
TOX.I.S.™, Basic Drugs . . . . . . . . . . . . . . . . . . . . . . . . . 18 - 19
Lysine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Nitrazepam . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Primidone . . . . . . . . . . . . . . . . . . . . . . . . 92 - 97, 146, 173, 202
TOX.I.S.™, Pharmaceuticals . . . . . . . . . . . . . . . . . . . . . 20 - 21
Magnesium . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Nitrazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Proline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
TPP (Thiaminepyrophosphate) . . . . . . . . 74 - 75, 80 - 81, 150,
Malondialdehyde . . . . . . . . . . . . . . . . . . . . . . . 68 - 69, 171, 201
Norclobazam . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Propionylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 177, 207
Malonylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Norclomipramine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Pyridoxal . . . . . . . . . . . . . . . 78 - 81, 150, 176 - 177, 206 - 207
trans-Cl2-CA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Mandelic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Norclozapine (Desmethylclozapine) . . . . . 104 - 105, 147, 149,
Pyridoxal-5-phosphate (PLP) . . . . . . . . 78 - 81, 150, 176 - 177,
Trazodone . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Manganese . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 175, 199, 204
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 - 207
Triazolam . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Maprotiline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Nordiazepam . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Quetiapine . . . . . . . . . . . . . 104 - 105, 147, 170, 175, 199, 204
Triazolam-d4 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Maraviroc . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Nordiazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Raltegravir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Trichloroacetic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Maraviroc-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Nordoxepin . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Raltegravir-d3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Tricyclic Antidepressants . . . . . . . . . . . . . . . . . . . . . . . . . . . 175
MBzP [Mono-benzylphthalate] . . . . . . . . . . . . . . . . . . . . . . . 197
Norepinephrine . . . . . . . . . . . . 22 - 31, 147, 168, 171, 196, 199
Retigabine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Trimipramine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
MDA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Norflunitrazepam . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Retinol, all-trans (Vitamin A) . . . . . . . . . . 72 - 73, 150, 176, 206
Trisialotransferrin . . . . . . . . . . . . . . . . . . . . . . 12 - 17, 147, 203
Medazepam . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Normetanephrine . . . . . . . . . . . . . . . . . . 32 - 37, 149, 168, 196
Riboflavine (Vitamin B2) . . . . . . . . . . . . . . . . . . . . . . . . . . . . 150
Tryptophane . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
5-oxo-MEHP [Mono-(2-ethyl-
Nortriptyline . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Risperidone . . . . . . . . . . . . 104 - 105, 147, 170, 175, 199, 204
Tyrosine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
5-oxohexyl) phthalate] . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197
Octadecanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Ritonavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Ubiquinone (Coenzyme Q10) . . . . . . . . . 66 - 67, 148, 171, 200
5-cx-MEPP [Mono-(2-ethyl-
Octanoylcarnitine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206
Ritonavir-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Urea . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
5-carboxypentyl) phthalate] . . . . . . . . . . . . . . . . . . . . . . . . . 197
Olanzapine . . . . . . . . . . . . . 104 - 105, 147, 170, 175, 199, 204
Rufinamide . . . . . . . . . . . . . . . . . . . . . . . 94 - 97, 146, 173, 202
Uroporphyrin I . . . . . . . . . . . . . . . . . . . . . 60 - 61, 150, 169, 198
Mercury . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Ornithine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Saquinavir . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 138, 173, 202
Valine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Metanephrine . . . . . . . . . . . . . . . . . . . . . 32 - 37, 149, 168, 196
Oxazepam . . . . . . . . . . . . . . . . . 130 - 131, 138, 149, 174, 203
Saquinavir-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Valproic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Methadone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 147
Oxazepam-d5 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Selenium . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Vanadium . . . . . . . . . . . . . . . . . . . 169, 172, 175, 198, 201, 205
Methionine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198, 206
Oxcarbazepine . . . . . . . . . . . . . . . . 92 - 97, 146, 171, 173, 202
Serine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 170, 198
Vanillylmandelic acid (VMA) . . . . . . . . . . 42 - 47, 151, 170, 196
Methoxy acetic acid . . . . . . . . . . . . . . . . . . . . . . . . . . . 169, 197
Paliperidone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204
Serotonin . . . . . . . . . . . . . . . . 38 - 41, 150, 169, 172, 196, 199
Venlafaxine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
3-Methoxytyramine . . . . . . . . . . . . . . . . . 32 - 37, 149, 168, 196
Paliperidone (9-Hydroxy-Risperidone) . . . . . . . 104 - 105, 147,
Sertindole . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 205
Vigabatrine . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 173, 202
Recipe_Katalog_14-15_Ansicht.qxd:Recipe_Katalog_14-15.qxd 12.03.14 11:35 Seite 244
Index
Vitamin A . . . . . . . . . . . . . . . . . . . . . . . . 72 - 73, 150, 176, 206
Vitamin B1 . . . . . . . . . . . . . . . . . 74 - 75, 80 - 81, 150, 177, 207
Vitamin B2 . . . . . . . . . . . . . . . . . 76 - 77, 80 - 81, 150, 177, 207
Vitamin B6 . . . . . . . 78 - 79, 80 - 81, 150, 176 - 177, 206 - 207
Vitamin C . . . . . . . . . . . . . . . . . . . . . . . . 70 - 71, 151, 176, 205
Vitamin D2 . . . . . . . . . . 82 - 85, 134 - 135, 139, 151, 176, 205
25-OH-Vitamin D2 / D3 . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
25-OH-Vitamin D2 / D3-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Vitamin D3 . . . . . . . . . . . . . . . . . . . . . . 82 - 85, 134 - 135, 139,
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141, 151, 176, 205
25-OH-Vitamin D3-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141
Vitamin E . . . . . . . . . . . . . . . . . . . . . . . . 72 - 73, 150, 176, 206
VMA (Vanillylmandelic acid) . . . . . . . . . . 42 - 47, 151, 170, 196
Zaleplone . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Zinc . . . . . . . . . . . . . . . 169, 172, 175, 177, 198, 201, 205, 207
Ziprasidone . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 175, 204
Zolpidem . . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 138, 174, 203
Zolpidem-d6 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 140
Zonisamide . . . . . . . . . . . . . . . . . . . . . . . 94 - 97, 146, 173, 202
Zopiclone . . . . . . . . . . . . . . . . . . . . . . . . . . 130 - 131, 174, 203
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