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Serial Micro Sampling
Why SMS?
Conc entrations of Com pound X in M ous e P las m a (nM )
• For small animal studies
• Can eliminate the need to sacrifice
an animal per time point
• Can decrease inter-animal variability
commonly observed in small animal
PK/PD studies
• Can obtain PK information in PD animals
(Log) C onc entration (nM )
10000.00
1000.00
100.00
10.00
1.00
0.00
2.00
4.00
6.00
8.00
Time (Hour)
10.00
12.00
14.00
N = 9 animals dosed with Compound X
1 timepoint per animal
Advantages:
Concentrations of Compound X in Mouse Blood (nM)
– 1 mouse per time-course vs 1 mouse
per time point
• PK profile in the same animals as
the PD determination
• Decreased experimental variability
(Log) C onc entration (nM )
• Complete PK profile with fewer animals
10000.00
1000.00
100.00
10.00
1.00
0.00
1.00
2.00
3.00
4.00
Time (Hour)
5.00
6.00
7.00
N = 3 animals dosed with Compound X
6 timepoints per animal
Getting started is easy! Just contact your Technical Sale Rep to discuss your project, or
contact our Customer Success Team to set up an appointment with our technical staff.
215-795-2838
www.lampire.com
lampire@lampire.com