Life Sciences Outlook Long Island | 2015 Long Island The Long Island life sciences landscape will continue to grow as firms emerge from Cold Spring Harbor Laboratory in Nassau, as well as Stony Brook University and Brookhaven National Lab in Suffolk. Accelerate Long Island, an economic development initiative launched by the Long Island Association and the Broadhollow Bioscience Foundation, is actively seeking space across Long Island for growing biotech firms, cementing Long Island as a hub for small and mid-sized, growing firms. Major lab supply: Clusters of established lab stock with longtime industry presence Emerging lab supply: Areas with limited lab stock today that are poised for growth Life Sciences manufacturing supply: Clusters of manufacturing space devoted to pharmaceutical, biological or medical device & instrument manufacturing Nassau County overview Nassau County is well positioned for future life sciences growth, given its proximity to New York City facilities. New laboratory partnerships continue to develop at the rapidly expanding North Shore-LIJ Health System, which includes the Feinstein Institute for Medical Research. Nassau County is the setting for Cold Spring Harbor Laboratory, a 125 year-old biomedical not-for-profit laboratory, and home to lab-based companies such as Mirimus and Certerra. The Nassau County life sciences market is mainly comprised of owner-occupied laboratory facilities. Suffolk County overview The life sciences industry in Suffolk County is dominated by the federal government and Stony Brook University. Suffolk County is home to Brookhaven National Laboratory, a 4.0 million square foot multipurpose research lab facility funded by the U.S. Department of Energy, founded in 1947. The National Institute of Health has awarded Stony Brook University’s Center for Biotechnology a three-year $3.0 million grant to create the Long Island Bioscience Hub along with Cold Spring Harbor and Brookhaven Lab. Codagenix, Traverse Biosciences and Marrowsource Therapeutics received National Institute of Health funding in 2014 and are supported by the Stony Brook Long Island High Technology Incubator. The majority of life sciences establishments occupy owned facilities in a campus setting. A key trend to watch for is new pharmaceutical developments: three pharmaceutical companies are constructing build-to-suit buildings totaling 270,000 square feet in Islip. JLL | Long Island | Life Science Outlook | 2015 2 Cluster score: Economic scorecard 29,405 % life sciences to private employment 2.8% Year-overyear growth -1.1% 535 0.5% 3.1% Workforce Total life sciences Employment Establishments Funding 48.2 Total life sciences % to total U.S. VC funding* $719.5M 5.1% NIH funding $157.5M 0.7% Innovation Total life sciences % to all patent classes 1,713 21.7% Patents* The number of pharmaceutical and medicine manufacturing establishments in Suffolk increased over 25.0 percent since 2004. The NIH awarded $90.6 million to organizations in Suffolk and $40.8 million to organizations in Nassau County in 2014. *Includes NYC totals Long Island biotech jobs have grown approximately 60.0 percent since 1960, according to the Long Island Index. Pharmaceutical and medicine manufacturing employment lead life sciences employment growth, having increased over 50.0 percent since 2004 in Suffolk. In Nassau, employment in medical and diagnostic laboratories increased over 40.0 percent since 2004. Life sciences employment composition Pharma & medicine manufacturing 13.0% 28.0% Life sciences employment 29,405 6.0% 36.0% 17.0% non-lab using Electromedical instrument manufacturing Medical equipment & supplies manufacturing Testing laboratories lab using Research & development Medical & diagnostic laboratories Life sciences patents by classification 2.8% Life sciences patents 1,713 Medical equipment & instruments 37.0% Pharmaceuticals & biotechnology 60.0% Crop science Life sciences patents for drug, bio-affecting and body treating compositions increased over 20.0 percent since 2000 in the metro area. Stony Brook University faculty are responsible for numerous patents. Stony Brook received 157 rewards from the NIH, worth $48.1 million, in 2014. Further, Suffolk County is the state’s largest agricultural county by crop value. JLL | Long Island | Life Science Outlook | Spring 2015 3 Nassau County Nassau County Proximity to NYC, 16.5 percent vacancy and low rent, positions market for growth • • • • • • In April 2015, Cold Spring Harbor Laboratory and North Shore-LIJ Health System formed a cancer research partnership in Lake Success, Western Nassau. North Shore-LIJ has invested more than $175 million to expand cancer treatment centers throughout Long Island. Additionally, Cold Spring Harbor Laboratory received $35 million in funding from the National Institute of Health in 2014. The Feinstein Institute for Medical Research is part of the North Shore-LIJ Health System and is headquartered in Manhasset, Western Nassau. The institute received $33.9 million in funding from the National Institute of Health in 2014 and specializes in autoimmune diseases, neurodegenerative diseases and cancer. Though the vacancy rate slightly decreased to 16.5 percent, there is available quality lab space in Nassau, including 24,000 square feet at 177 Cantiague Rock Road in Westbury. Port Washington-based Aceto Corporation, a manufacturer of drugs and chemicals, is rapidly expanding. Aceto recently purchased three drugs from Par Pharmaceuticals for $8.2 million. Angion Biomedica, a clinical stage biopharmaceutical company established in 1998, leased 40,000 square feet at 51 Charles Lindbergh Boulevard in Uniondale in 2011. In Eastern Nassau, two renewals were signed. Shore Pharmaceutical Providers signed a renewal for 40,000 square feet at 55 West Ames in Plainview. Bioreclamation, a provider of biological products to life sciences and pharmaceutical companies, signed a renewal at 123 Frost Street in Westbury. Facilities scorecard Nassau County Major lab Supply Rentable lab stock (% of total stock) 424,429 s.f. 77.0% Direct vacancy (Change year-over-year) 16.5% (-1.0)% # of large blocks over 100,000 s.f. 0 Under construction (s.f.) 0 Demand # of requirements Total s.f. requirements 1 80,000 s.f. Pricing Average asking rent (NNN) (Change year-over-year) $15.33 p.s.f. (1.0)% ANGION BIOMEDICA CORP. 51 Charles Lindbergh Boulevard, Uniondale 40,000 s.f. Term: 15 years SHORE PHARMACEUTICAL PROVIDERS 55 West Ames, Plainview 40,000 s.f. Term: 10 years Renewal 177 CANTIAGUE ROCK ROAD Westbury 24,100 s.f. Class A Direct options BIORECLAMATION INC. 123 Frost Street, Westbury 16,000 s.f. Term: 7 years Renewal and Expansion Leasing Under construction Sales Large blocks of space Activity key: JLL | Long Island | Life Science Outlook | 2015 4 Suffolk County Suffolk County Build-to-suits drive new construction activity • • • • • • • • • In Suffolk County, space options increased over the last year, comprised of lab space formerly occupied by OSI Pharmaceuticals. Hence, the Suffolk County vacancy rate increased 4.6 percent to 23.7 percent year-over-year. OSI Pharmaceuticals canceled the company’s 62,000-square-foot lease at Farmingdale State College’s Broad Hollow Bioscience Park in 2014, leaving 45,000 square feet of lab space available. The park is a nonprofit partnership between Farmingdale State and Cold Spring Harbor Lab. There are two active Suffolk County requirements totaling 80,000 square feet. The majority of tenants require 10,000 to 40,000 square feet. The largest transaction of 2014 was Steel Equities’ purchase of Forest Laboratories’ headquarters at 500 Commack Road for $25 million, due to the Forest consolidation. Actavis PLC purchased Forest Labs for $25 billion in 2014 and Forest announced it would close six of its seven facilities in Suffolk. Pharmaceutical manufacturer A&Z is expanding in Suffolk and purchased a 118,000-square-foot building at 350 Wireless Boulevard in Hauppauge. Two Hauppauge-based pharmaceutical companies are expanding operations onto an 18-acre parcel in Central Islip. InvaGen is constructing a 125,000-square-foot facility and Alpha Med Bottles is constructing a 70,000-square-foot facility on Carlton Avenue. Centereach-based Spirit Pharmaceuticals LLC will construct a 75,000-square-foot building in Islip. The $15 million expansion project will consolidate the Centereach office and the 55,000 square feet it occupies at 2004 Orville Drive North, Ronkonkoma. The proposed factory will be in the town's foreign trade zone. Contract Pharmacal Corp. in Hauppauge, a manufacturer of over-thecounter drugs, vitamins and dietary supplements, plans to invest $4.0 million in its seven Hauppauge plants. Stony Brook University R & D Park is a 246-acre parcel of open land available for development. The space will be built in response to demand from Start-Up NY designated companies. Stony Brook University has several business incubators with space available for Start-Up NY Companies. Start-up NY provides tax incentives for businesses to expand through affiliations with universities. Facilities scorecard Suffolk County Major lab Supply Rentable lab stock (% of total stock) 381,376 s.f. 10.5% Direct vacancy (Change year-over-year) 23.7% (4.6)% # of large blocks over 100,000 s.f. Under construction (s.f.) 0 270,000 s.f. Demand # of requirements Total s.f. requirements 2 80,000 s.f. Pricing Average asking rent (NNN) (Change year-over-year) $16.90 p.s.f. (1.0)% A&Z PHARMACEUTICALS 350 Wireless Boulevard Hauppauge 118,042 s.f. Class C $12.6M / $107 p.s.f. INVAGEN PHARMACEUTICALS 275 Carlton Avenue, Islip 125,000 s.f. Expected delivery: 2016 BROADHOLLOW BIOSCIENCE PARK Farmingdale 45,000 s.f. Class A Direct lease SPIRIT PHARMACEUTICALS Islip 75,000 s.f. Expected delivery: 2016 Leasing Under construction Sales Large blocks of space Activity key: JLL | Long Island | Life Science Outlook | 2015 5 For more information, please contact: Stephen Jenco Vice President, Suburban Tri-State Research +1 (201) 528-4454 steve.jenco@am.jll.com About JLL JLL (NYSE: JLL) is a professional services and investment management firm offering specialized real estate services to clients seeking increased value by owning, occupying and investing in real estate. With annual fee revenue of $4.0 billion and gross revenue of $4.5 billion, JLL has more than 200 corporate offices, operates in 75 countries and has a global workforce of approximately 53,000. 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