Faculty of Science Overall impression 2013 Introduction The year 2013 put the spotlight on the Faculty of Science’s top research, both in the Netherlands and abroad, because of many prestigious awards including a Spinoza Prize, Gravitation subsidies, an ERC Synergy Grant and many others. Our Professors have stepped up their efforts to join forces with related disciplines and further developed a focus on various social challenges such as sustainable energy, fundamentals of health, future food and understanding complex systems. We believe that is of vital importance to build a bridge between fundamental research and the challenges the world is facing, because it enables us to make a valuable contribution to the progress of science while being a strong knowledge partner for society and the business community. We therefore view educating students as a great privilege, not only because we want our students to contribute to top science in the future, but also because we want to teach them the knowledge and skills that will enable them to make a difference in the world. I am proud of what our faculty achieved this year and I want to share my pride with you by looking back on the past year by means of the telling examples in this overall impression of 2013! Professor Gerrit van Meer Dean of the Faculty of Science Research areas The Faculty of Science is committed to the following research themes: Research theme Foundations of Complex Systems Research theme Future Food Research theme Research theme Game Research Integrative Bioinformatics Research theme Research theme Science for Life Water, Climate & Ecosystems The faculty also makes a significant contribution to the following research focus areas of the Utrecht University: 1 Focus areas Focus areas Education for Learning Societies Future Deltas Focus areas History and Philosophy of the Sciences and the Humanities Focus areas Neuroscience & Cognition Utrecht Research theme Energy & Resources Education Pharmaceutical Sciences & CPS Source: Studielink/VSNU, overview of 30 September 2013 compared to 2012 119 141 728 145 2013 2012 142 2013 2012 142 52 105 160 2013 2012 School of Pharmacy 206 2013 2012 199 79 82 112 2013 2012 Graduate School of Life Sciences 344 2013 2012 120 368 251 213 233 Chemistry 2013 2012 Graduate School of Natural Sciences Mathematics / Mathematics & Applications 403 Information Technology Intake 1129 Information and Computing Sciences Physics and Astronomy Master's programmes 1132 Biology Intake 2013 2012 2013 2012 2013 2012 2013 2012 2013 627 Bachelor's programmes 2012 Source: Bio-BT management data. Overview of September and February, intake in the academic year 2013/2014 compared to 2012/2013 The 2013 intake of students in Master’s programmes was at the regular level again after a slight decrease between 2011 and 2012. We noticed an increase for several programmes of the Graduate School of Natural Sciences. At the Graduate School of Life Sciences the increase was mainly due to the greater popularity of the programme Molecular and Cellular Life Sciences. 2 Education State Secretary Dekker finds inspiration for talent policy at U-Talent Academy In September 2013, more than 100 students from 5VWO classes started the U-Talent Academy, the new programme of the Faculty of Science for talented and motivated VWO students of Junior College Utrecht. U-Talent Academy offers students a wide and all-encompassing introduction to themes from the science subjects, a thorough orientation on scientific research and attention to personal development study attitude. On 11 November, State Secretary Dekker visited U-Talent Academy. He talked to the secondary school students and teachers involved about their experiences. “The entire education system and all individual students will benefit from talent policy”, Dekker said. 3 A thesis that reads like a novel Education Best Master’s thesis for Pablo Acuña Luongo Pablo Acuña Luongo, graduate of the Master’s programme History and Philosophy of Science, won Utrecht University’s 2013 thesis prize in the category ‘Best Master’s Thesis’. In his thesis, he combined philosophy of science and physics. “His thesis is written in a clear and exciting way and reads like a novel”, said the judges. They also praised him for the wide range, applicability and accessibility of his work. Five science Bachelor students make the selection Christine Verbeke wins Student Research Award From among more than 120 submissions, the research of Christine Verbeke, student of Physics and Astronomy at Utrecht University, was awarded the Student Research Award 2013, a €1,500 prize for the best Bachelor research in the Netherlands. According to the jury, Verbeke’s research into future energy sources is a highly relevant and innovative subject. The jury also praised her for the clear way she presented her research. 4 Valorisation and outreach ‘Creative industry’ subsidy for Time Capsule and Mycelium Design TNO and NWO established the Creative Industry programme to make scientific knowledge accessible to the creative industry, to develop new knowledge and to establish connections between science and practice. In 2013, the Faculty of Science received two subsidies from the programme, one for the research programme Time Capsule and one for Mycelium Design. Time Capsule By combining different databases, Toine Pieters, Professor of Pharmaceutical Sciences, looks for connections between the medicinal benefits of plants that are not obvious at first glance. Pieters: “All databases use different semantics, which makes it difficult to compare them. Therefore, we started working with information scientists to create a semantic thesaurus which can compare the databases. 5 It is a ground-breaking, digital historical research that combines old and new knowledge.” The acquired knowledge can be linked to current medication and offers advantages to future medication research. Mycelium design The toadstool species Schizophyllum has a network of hyphal threads, which is called the mycelium. The mycelium found on the Chinese Wall appears to have different features than those found in Dutch woods. “We want to find out which genes are responsible for these features and what the relevance is in nature”, says Han Wösten, Professor of Biology. Several designers and architects are also working with the fungus in the project. Their goal is to make sustainable materials from the fungus and to incorporate them in contemporary products. Valorisation and outreach Simulating large crowds in 3D Crowdsourcing with tea bags How does a large crowd move through a train station or at an event such as King’s Day? Information scientists of Utrecht University developed new generation software to accurately simulate crowd movements. The software programs offers life-like, super-fast and super-easy 3D simulations of crowds of up to 80,000 people. The software program’s principle is derived from Utrechts gaming research. Utrecht-based company INCONTROL Simulation Solutions uses the software program, for example, to simulate walking routes for NS/ProRail at large train stations in the Netherlands that are being renovated. Together with a team of international scientists, Utrecht ecologists Joost Keuskamp, Bas Dingemans and Margriet Hefting thought of a way to conduct cheap and easy soil research: the Tea Bag Index. Tea bags contain plant material. Burying them in soil for a while is a simple way to measure how long the decomposition process takes. By comparing decomposition at various locations across the world, it is easier to predict the consequences of climate change. Game ‘Hooked!’ discovers secret to popular songs What is it that makes you immediately recognise that wellknown song? Why does one song stick in your head and the other does not? In order to find out more about this, researchers of Utrecht University, the University of Amsterdam and the Netherlands Institute for Sound and Vision developed Hooked!, a game with music from the Radio 2 Top 2000. Hooked! can be downloaded for free and the players’ answers are used as research data. 6 Subsidies & Grants Faculty of Science part of prestigious Gravitation programme With the Gravitation programme, the Dutch Ministry of Education, Culture and Science and research financier NWO invest in long-term and large-scale top research. The Faculty of Science was closely involved in three of the six awarded proposals, thereby providing an important contribution to Utrecht University’s strategic themes ‘Sustainability’ and ‘Life Sciences’. 7 Subsidies & Grants Out of the box cooperation in catalysis research € 31,9 million Chemical immunology: a new discipline € 27,6 million Reading the past to predict the future € 28 million At the Netherlands Center for Multiscale Catalytic Energy Conversion, researchers of Utrecht University (coordinator), TU Eindhoven and Twente University joined forces to radically change processes with which fuels and chemical building blocks are made. The goal is to develop new catalysis processes and to perfect existing ones at all relevant scales: from the atomic level up to the level of the actual reactor in which the catalysis takes place. If a person’s immune system does not function properly, infection and cancer may develop. If it functions too well, this may lead to auto-immune diseases, meaning that the body attacks its own immune system, such as is the case with rheumatoid arthritis and multiple sclerosis. Increasing knowledge of how this works at the molecular level is the way to successfully tackle diseases. This knowledge will enable researchers to develop innovative medication. Researchers of the Netherlands Cancer Institute, Leiden University, Utrecht University and UMC St Radboud have therefore developed a new discipline: chemical immunology. At the joint Institute for Chemical Immunology (ICI) the immunologists and chemists conduct joint research and develop a multidisciplinary programme. The Netherlands Earth System Science Centre (ESSC) is focused on research into climate of the past, present and future to be able to better predict future climate circumstances on our planet. The new centre brings together paleoclimatologists, bio-geo scientists and climate modellers. Bert Weckhuysen, Professor of Chemistry: “This subsidy from the Ministry of Education, Culture and Science and NWO is a huge appreciation and boost for all researchers involved and will undoubtedly work like a magnet for talent, also from abroad.” Bert Weckhuysen (Chemistry) is the lead applicant and Alfons van Blaaderen (Physics and Astronomy) the fellow applicant. On behalf of the Faculty of Science, climate researchers of the Institute for Marine and Atmospheric Research Utrecht (IMAU), under the supervision of Hans Oerlemans, Professor of Physics & Astronomy, Utrecht University are involved in the centre. “You have to know your enemy to beat him”, says fellow applicant Albert Heck, Professor of Biomolecular Mass Spectrometry and Proteomics. 8 Personal awards NWO-Spinoza NWO-Vici Bert Weckhuysen (Chemistry) Marius Crainic (Mathematics) NWO-Vidi Ronald Pierik (Biology) NWO-Vidi Maarten Altelaar (Pharmaceutical Sciences) ERC-Synergy Grant NWO-Vidi ERC-Synergy Grant Anna Akhmanova (Biology), (in cooperation with Marileen Dogterom, Professor of Technical Sciences of AMOLF/TU Delft) Leonie Bentsink (Biology) NWO-Vidi NWO-Veni NWO-Veni Umut Gursoy (Physics) Harold Mac Gillavry (Biology) Lukas Kapitein (Biology) Tom Groot Kormelink (Pharmaceutical Sciences) NWO-Veni Daniele Sepe (Mathematics) NWO-Veni Laura Filion (Physics) ERC-Advanced Grant Krijn de Jong (Chemistry) ERC-Advanced Grant ERC-Consolidator Grant ERC-Consolidator Grant Frank de Groot (Chemistry UU / Stanford University US) Jan Broersen (Information and Computing Sciences) Casper Hoogenraad (Biology) Contract cases in 2013 Type of contract Bilateral consultancy contracts Total 2012 3 3 23 24 7 6 Consortium agreements 20 5 Non-disclosure agreements 20 9 Material transfer agreements 15 13 6 12 13 13 107 85 Bilateral contracts with a company Bilateral contracts with a university Cooperation agreements (including PPC) Other contract cases Totals 9 Total 2013 NWO-Vidi en ERC-Starting Grant NWO-Veni Celia Berkers (Chemistry) Research Key figures Scientific publications PhD theses 2013 2012 1834 1715 146 139 Source: Metis Research volume 2013 per department; in FTEs and broken down by type of funding¹ Type of funding Biology 1 34 Pharmaceutical Sciences Physics and Astronomy 32 29 Chemistry Mathematics Information and Computing Sciences Total 35 18 16 164 201 2 65 17 35 50 13 21 3 35 66 10 42 17 14 185 Total 2013 135 115 74 127 48 51 550 Total 2012 134 119 107 107 39 53 559 Source: Metis 1 Government funding(1) is a grant for Utrecht University from the Ministry of Education, Culture and Science. Indirect funding (2) comprises grants from research financiers NWO - including STW and FOM - and KNAW for research programmes as well as personal grants, such as Veni, Vidi and Vici grants. Contract funding (3) comprises grants from all other financiers, such as the EU, ministries, companies and non-profit organisations. 10 Publications Increasing susceptibility New insight into the effects of cancer medication Chemotherapy is an effective way to fight tumours, but it has severe side-effects and sometimes tumours become insusceptible to medication. If you want to develop new and better medication, it is very important to understand how the medicinines interact with our cells. By applying advanced microscopic techniques, cell biologists of the Faculty of Science discovered that certain proteins make the cellular tubes more susceptible to medication. Anna Akhmanova, Professor of Cell Biology: “Our results could contribute to finding better cancer medication.” The results of the research funded by NWO and the European Commission were published in the renowned journal PNAS in May 2013. New instrument detects hundreds of organic substances over forest Climate researchers of Utrecht University and the University of Berkeley (US) have managed to make a detailed measurement of the uptake and emission of organic substances. So far this was only possible for the most important substances that are responsible for that typical forest smell, but now the researchers were also able to measure hundreds of 11 other substances. This knowledge is vital for a better understanding of the influence of plants on the climate. Rupert Hilzinger, Utrecht University “Our new tool is important to increase our understanding of our climate system’s biosphere.” An article about the research was published in the renowned journal Science. Ultra-thin graphene electrical wires Electronics will become faster and more advanced in the future. The semi-conductors we use now will no longer be able to cope, calling for new materials with better conductivity. Dr Ingmar Swart and colleagues of Utrecht University and Aalto University (Finland) have successfully established electrical contact with tiny graphene wires through a single chemical connection. Thanks to its unique electrical properties, graphene is a promising material for use in future computers. The results were published in 2013 in the renowned scientific journal Nature Communications. Too small for Archimedes Does an object float on top of a fluid, or not? That was the question chemists of Utrecht University and the FOM Foundation studied in their research of tiny solid particles only a few nanometres in size. Their research is relevant for studies into quantum dots, which are tiny semi-conductor crystals with quantum mechanical features. Under UV light they emit light of a varying Publications colour, depending on the size of the particle. Ben Erné: “On the surface of a fluid, the particles will arrange themselves in a nice grid. We can scoop them up from that fluid phase and use them in other applications. For the first time ever we have successfully created a 3D image of the surface of the liquid.” The research results were published in the journal Physical Review Letters. New model for the development of blood cells Protection against most toxic substance discovered A research team led by Utrecht University and the Swiss Paul Scherrer Institute developed a substance that protects nerve cells against the highly toxic substance botulinetoxine. The protective substance is interesting for a number of applications. “This means that an antidote could possibly be developed to protect people from the toxic substance botulinetoxine as a preventative measure”, says Casper Hoogenraad, Professor of Cellular Dynamics at the Faculty of Science. “Our substance could also be developed further to improve existing medical and cosmetic applications of botulinetoxine.” Theoretical biologist Professor Rob de Boer and researchers of the Netherlands Cancer Institute are developing a barcode technique to follow cells and their successors. De Boer: “The barcode has made it possible for us to follow cells in live organisms instead of only in petri dishes.” The codes yield an incredible amount of complex data. After all codes are processed, De Boer applies various mathematical models to translate the complex data into simpler underlying mechanisms. The Utrecht analyses were published in Science and Nature. The research results were published in the renowned journal Nature. In this short movie Utrecht researchers Josta Kevenaar and Casper Hoogenraad explain their research. 12 Dynamic study societies Photo: PiXel commissie Studievereniging Sticky Like every year, Utrecht study societies organised many interesting meetings and fascinating study trips in 2013. Below are a few examples of such events. At the Chemistry and Safety symposium, Chemistry students talked with companies about security measures regarding the handling of chemical substances. Organised by study society U.S.S. Proton society Sticky M.B.V. Mebiose Utrechtse Biologen Vereniging (UBV) U.S.S. Proton Unitas Pharmaceuticorum TEDx is one of the largest career-oriented activities Mebiose organised for medical biologists. Renowned scientists and successful alumni hold short talks about their careers. The keynote speaker was Anton Pijpers, Dean of the Faculty of Veterinary Medicine of Utrecht University. Organised by study society M.B.V. Mebiose 13 Study societies of the Faculty of Science In Dublin, Europe’s Silicon Valley, students visited IT giants Microsoft, Google, Riot Games, SAP and LinkedIn. Organised by study A-Eskwadraat Sticky Incognito Organisatie From left to right: Hans Dröge (alumnus of Pharmaceutical Sciences), Dennis Hesseling (alumnus of Mathematics), Diederik Zijderveld (alumnus of Biology), Thekla Teunis Msc Beatrice Boots (alumna of the Faculty of Geosciences), Missing is ir. Marijke Vos, alumna of Biology of Wageningen University and member of the Senate for GroenLinks. (alumna of Mathematics, alumna of Language and Culture Studies), Linking in with top sector policy Board team of the Faculty of Science The Faculty of Science has had a Social Advisory Committee since the end of 2012. The six members of the council act as a sounding board for the Faculty Board in the area of strategic choices in education and research. In 2013 the committee members could seriously start their work. Important points of attention this year were the new strategy and the research focus areas of Utrecht University. “We join the discussion about priority areas and how the programme of the Faculty of Science can link up with the top sector policy”, says Hans Dröge, alumnus of Pharmaceutical Sciences and member of the Social Advisory Committee. “Interdisciplinary cooperation in one programme with an external focus on social issues will I believe lead to new insights, in the interest of science and the Dutch economy.” Gerrit van Meer, Dean Sjef Smeekens,Vice Dean of Research Gerard Barkema,Vice Dean of Education Klaas Druijf, Faculty Director Felix Nolet, student member Organisational chart of the Faculty of Science Dean Faculty Council Board team Faculty Director Biology Services Pharmaceutical Sciences Chemistry Faculty of Science in FTEs Physics and Astronomy Permanent FTEs) Temporary (FTEs) Academic staff 264 of who 72 Professors m/f: 81/19% 564 of who 354 PhD candidates m/f: 62/38% total 828 Non-academic staff 311 m/f: 56/44% 43 m/f: 44/56% 354 Total 2013 575 607 1182 Total 2012 642 733 1375 Reference date: 31-12-2013 in FTEs (excl. teaching assistants/interns/on-call employees/declarants) Computing Sciences Mathematics Graduate School of Natural Sciences / Research institutes Graduate School of Life Sciences / Research institutes Undergraduate School of Sciences School of Pharmacy The Faculty of Science efficiently uses its funds. The overhead/turnover ratio is not higher than 20% (result of Utrecht University in Berenschot benchmark 2013). Within this percentage, a shift from general support to direct support of education and research takes place, if possible. 14 This is a publication of the Faculty of Science of Utrecht University. Editors: Irma Vermeend, Robert Kerst, Irma van Zand Design: Pieter van Dorp van Vliet Photograpy: Ivar Pel, Ed van Rijswijk, Arno Kamphuis, Pieter van Dorp van Vliet, Hollandse Hoogte For more information on the faculty of Science, please visit our website: http://bit.ly/1xXTM3B