Dear Publisher: Thank you for your attention to the enclosed submission. This article is based on research that was funded in whole or in part by grants from the Canadian Institutes of Health Research (CIHR) and is therefore subject to the CIHR policy on Access to Research Outputs (see http://www.cihr.ca/e/32005.html). According to this policy, all research papers generated from CIHR funded projects must be made freely accessible through the Publisher’s website or an online repository within six months of publication. In order to ensure compliance with this mandate, and to be sure that copyrights are addressed appropriately, we ask that the enclosed Addendum to the Copyright Agreement be signed and returned. This addendum retains the right to archive the final, peer-reviewed version of the manuscript in a digital repository and to make the manuscript freely available from that repository 6 months after the date of publication in the Journal. Thank you for your consideration and cooperation. Sincerely,