Christine Ann Caneba, CV
1815 University Avenue, Apartment 410 * Madison, WI 53726 * 920-284-9154 * Christine.caneba@gmail.com
Ph.D. Bioengineering
Rice University, Houston, TX
Aug 2008 - Dec 2013
GPA 3.9/4.0
Thesis Advisor: Prof. Deepak Nagrath
Thesis: Ovarian Cancer Metabolism: Effect of Anoikis Condition and Nitric Oxide on Ovarian Cancer
Metabolism, and Effect of Metabolites on Ovarian Cancer Migration
Aug 2003 - May 2007
GPA 3.4/4.0
B.S. Chemical and Biomolecular Engineering
Minor, Biomedical Engineering
Cornell University, Ithaca, NY
Biomedical Engineering Postdoctoral Research Fellow
University of Wisconsin – Madison, Madison, WI
Mentor: Prof. Naomi Chesler
April 2014 - Present
Research Area: Cell metabolism, vascular and pulmonary cell biology, tissue engineering
Project:

Designed and carried out experiments to elucidate the role of metabolism in pulmonary arterial hypertension (PAH) and right ventricular failure secondary to PAH
Bioengineering Researcher
Rice University, Houston, TX
Thesis Advisor: Prof. Deepak Nagrath
Aug 2008 - Dec 2013
Research Area: Cancer metabolism and biology, anoikis, and nitric oxide
Project:
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Designed and conducted experiments to gain insight into the metabolism of ovarian cancer cells in metastasis

Trained 12 students in mammalian cell culture, metabolic assays, wound healing migration assays, cell viability assays, light microscopy, image analysis, western blotting, and scientific figure production

Presented research findings during poster sessions at American Association for Cancer
Research (AACR) conferences
Howard Hughes Predoctoral Fellow
MD Anderson Cancer Center, Houston, TX
June 2009 – Dec 2013

Awarded highly selective internship (June 2009 – August 2009), which involved completing clinical rotations in cancer clinics
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Christine Ann Caneba, CV
Scientist I – Product Developer, Child Care Team
Kimberly-Clark Corporation, Neenah, WI
July 2007 - Aug 2008
Project:

Led studies to improve the aesthetics and performance of Huggies® Pull-Ups Training Pants

Collaborated with apparel design personnel, engineers, and marketing personnel

Communicated results to teammates and management during meetings and in technical reports

Product was as a result promoted to the next stage of development
Undergraduate Biomedical Engineering Researcher
Cornell University, Ithaca, NY
Research Advisor: Prof. Michael Shuler
May 2006 - Feb 2007
Project:

Worked on project to develop lab-on-a-chip that could measure the efficacy and toxicity of inputted drugs to organ tissues seeded in chambers on the chip

Designed and carried out experiment which involved exposing liver cells to cancer pro-drug
Tegafur under static conditions
Product Development Co-op, Developing and Emerging Markets May 2006 - Aug 2006
Kimberly-Clark Corporation, Neenah, WI
Project:

Designed and conducted bench tests to determine parameter for use in computer model of fluid analysis in Huggies® diapers

Results helped determine potential product dimensions for developing markets
Product Development Co-op, Health Care Explore Team Aug 2005 - Dec 2005
Kimberly-Clark Corporation, Roswell, GA
Project:

Conducted phone interviews and in-hospital observational studies to explore hand hygiene in hospitals

Collaborated with engineers, scientists, and marketing personnel

Communicated findings to management in presentation

Project was as a result continued to the next development phase

Imaging: Fluorescence microscopy, confocal microscopy, light microscopy

Cell Culture: Sterile culture technique, three-dimensional spheroidal culture, fibrin gel culture

Cell Biology and Biochemistry: Oxygen consumption rate (OCR) measurements, ultra-high performance liquid chromatography, metabolic assays, enzymatic assays, flow cytometry, histology, western blot, PCR

Computer Software: Sigma Plot, ImageJ, Microsoft Office, Adobe Illustrator

Computer Languages: Matlab, JAVA, R

Animal Handling: Mouse and rat handling/surgery
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Christine Ann Caneba, CV

Caneba, C.
, Achreja, A., D. Nagrath. “The role of the mitochondria in cancer metastasis.” In preparation for American Journal of Physiology. 2015

Salimian B., Caneba, C ., Nowicka A., Nabiyar A.W., Liu X., Klopp, A., D. Nagrath. “Nitric oxide mediates metabolic coupling of omentum-derived adipose to ovarian and endometrial cancer cells .” Cancer Research. 2014

Caneba, C.
, Yang, L., Baddour, J., Curtis, R., Win, J., Hartig, S., Marini, J., D. Nagrath. “Nitric oxide is a positive regulator of the Warburg ef fect in ovarian cancer cells.” Cell Death and
Disease. 2014

Caneba, C.
, Bellance, N., Yang, L., Pabst, L., D. Nagrath. “Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration.” American Journal of Physiology – Endocrinology and Metabolism. 2012 Oct 15;
303(8):E1036-52

Nagrath, D., Caneba, C.
, Karedath, T., N. Bellance . “Metabolomics for mitochondrial and cancer studies.
” Biochimica et Biophysica Acta. 2011 Jun; 1807(6):650-63
 Poster Presentation for American Association for Cancer Research Annual Meeting, “Effect of nitric oxide on invasiveness and metabolism of cancer cells”, 2013

Poster Presentation for American Association for Cancer Research Annual Meeting, “Study of altered metabolism due to anoikis resistance in ovarian cancer”, 2011
 Patent Application at Rice University, “Regulating ovarian cancer through pyruvate”, June 26,
2012

Patent Filed at Kimberly-Clark Corporation, “Personal wear absorbent article with disposal tab”,
December 3, 2009

NIH T32 Fellowship – Training Program in Translational Cardiovascular Science, 2014 - Present

Institute of Biosciences and Bioengineering (IBB) High School Student Mentor, 2012

O'REAR Travel Grant Winner, 2010

Howard Hughes Predoctoral Fellow, 2009

Rice University Bioengineering Tuition Award for full funding towards Ph.D., August 2008

American Heart Association, 2014 - Present

American Association for Cancer Research, 2010

Animal Surgical Training, University of Wisconsin – Madison, April 2014 - May 2014

Human Embryonic Stem Cell Training, Baylor College of Medicine, October 2010
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Christine Ann Caneba, CV

Fluorescently Activated Cell Sorting Training, Rice University, October 2010

Teaching Assistant: Mechanical Testing Lab, Rice University, Fall 2012

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Teaching Assistant: BIOMEMS and Medical Microdevices, Rice University, Spring 2010
Teaching Assistant: Introduction to Gene Therapy, Rice University, Fall 2009

Teaching Assistant: Fundamentals of Systems Physiology, Rice University, Spring 2009

Achievement Connections Tutor, Madison, WI, 2014-Present

Math Achievement Partnership Tutor, Appleton, WI, 2014

Old School Tutor, Houston, TX, 2013

Graduate Representative for Recreation Center Committee, Rice University, 2013
 First place overall in Women’s South Central Cycling Conference, Rice University, 2012

Rice University Cycling and Triathon Treasurer, Rice University, 2012-2013

Rice University Cycling and Triathlon Sponsorship Chair, Rice University, 2011-2012
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Bioengineering Graduate Student Association Communications Chair, Rice University, 2011-2012

Graduate Student Association Community Service Chair, Rice University, 2010-2012
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