Elanco Cattle Vaccine Portfolio Use Recommendations Calves Recommended vaccinations Disease Segment Respiratory Heifers Branding/ Turnout Pre-weaning Weaning Titanium 5+PH-M Titanium 5 Vira Shield 6 Titanium 5+PH-M Titanium 5 Vira Shield 6 Titanium 5+PH-M Titanium 5 Master Guard 5= Vira Shield 6 Vira Shield 6+L5 HB Vira Shield 6+L5 HB Reproductive (replacement females) Titanium 5 L5 HB Master Guard 10 HB= Vira Shield 6+VL5 HB (2 doses) Scours Pinkeye Titanium 5 L5 HB Master Guard 10 HB= Vira Shield 6+L5 HB Prebreeding Titanium 5 L5 HB Master Guard 10 HB= Vira Shield 6+VL5 HB Scour Bos 4 Pregcheck Precalving Titanium 5 L5 HB Master Guard 10 HB= Vira Shield 6+L5 HB* Scour Bos 9 Turnout Fusogard (2 doses) Quick Shield IN IBR PI3** Stocker Arrival Revaccinate (2-4 weeks) Titanium 5+PH-M Titanium 5 Master Guard 5= Vira Shield 6 Titanium 5+PH-M Titanium 5 Master Guard 5= Vira Shield 6+VL5 HB Scour Bos 4 NUPLURA PH Fusogard (2 doses) Fusogard (2 doses) NUPLURA PH NUPLURA PH Pinkeye Shield XT4 Pinkeye Shield XT4 Fusogard (2 doses) Quick Shield IN IBR PI3** Somnu Shield BRD Shield*** (2 doses) Reproductive (replacement females) Pneumonia Precalving Bulls NUPLURA PH Footrot Respiratory Pregcheck Scour Bos 9 Pneumonia Optional vaccinations Prebreeding Cows ReproSTAR VL5 HB ReproSTAR VL5 HB Pinkeye Shield XT4 Pinkeye Shield XT4 Pinkeye Shield XT4 Clostri Shield 7 Clostri Shield 7 Booster Clostri Shield 7 Clostri Shield 7 CP Type A CP Type A Booster CP Type A CP Type A Clostridial *Vira Shield 6+L5 HB may be used if cows are artificially inseminated. **Use Quick Shield only on calves nursing open cows. ***Use BRD Shield only on calves nursing open cows. Calves less than 6 months of age should receive another dose at weaning. = Master Guard may be used in calves at least 5 months of age. For all vaccine products: The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Somnu Shield Clostri Shield 7 Clostri Shield 7 Clostri Shield 7 Booster Elanco Cattle Vaccine Portfolio Use Recommendations Respiratory Protection BRD SHIELD ® • Noncytopathic BVD Type 1 and Type 2, IBR, BRSV, PI3 • Dosage: 2 mL dose, SubQ, booster in 3-4 weeks for the BRSV fraction. Calves vaccinated prior to six months of age should be revaccinated after six months of age. Revaccinate annually • Can be used safely in calves as young as four weeks. Not for use in pregnant cows or calves nursing pregnant cows ® QUICK SHIELD IN IBR-PI3 • IBR, PI3 • Dosage: 2 mL dose, intranasally or SubQ, revaccinate annually • Goes right to work at a common site of infection entry, the nostrils ® MASTER GUARD 5 • BVD, types 1 and 2, IBR, PI3, BRSV • Dosage: 3 mL, SubQ or IM, booster in 2-4 weeks with Master Guard 5 • Revaccinate annually. Calves vaccinated before weaning should be revaccinated 30 days after weaning • Approved for use in pregnant cows and nursing calves; may be used in calves at least 5 months of age • Unique combination of killed and MLV components that’s proven safe and effective against respiratory disease SOMNU SHIELD® • Histophilus somni • Dosage: 2 mL, IM or SubQ, booster in 2-3 weeks, revaccinate annually • Well-suited when cattle are grouped closely together in feedlots or when gathered for shipping or assembled for grazing fall and winter pasture. Protects again H. somni which is a leading cause of death in feedlot cattle. TITANIUM® 5 + PH-M • BVD, type 1 and 2, IBR, PI3, BRSV, M. haemolytica, P. multocida • Dosage: 2 mL, SubQ, booster in 2-4 weeks with monovalent BRSV vaccine (Titanium® BRSV) and M. haemolytica and P. multocida vaccine (PULMOGUARD® PH-M) to be given 14-28 days after the first dose. Revaccinate annually. Calves vaccinated before weaning should be revaccinated 30 days after weaning • Approved for use in pregnant cows and nursing calves; 60 days of age or older • Single-vaccine solution protects against BRD-causing viruses and bacteria TITANIUM 5 • BVD, types 1 and 2, IBR, PI3, BRSV • Dosage: 2 mL, SubQ, booster in 2-4 weeks with monovalent BRSV vaccine (Titanium® BRSV). Revaccinate annually. Calves vaccinated before weaning should be revaccinated 30 days after weaning • Approved for use in pregnant cows and nursing calves • Broad, proven, MLV protection against respiratory viruses at every stage of production Reproductive Protection VIRA SHIELD® 6+VL5 HB • Cytopathic (CP) BVD Type 1, noncytopathic (NCP) BVD Type 1, NCP BVD Type 2, IBR, BRSV, PI3, 5-way Lepto (including Lepto hardjo-bovis), Vibrio • Dosage: 5 mL, 2-4 weeks prebreeding, booster with Vira Shield 6+L5 HB in 4 weeks, SubQ, annual revaccination • First and only inactivated viral vaccine available in combination with a U.S. origin Lepto hardjo-bovis — the most common cause of leptospirosis in U.S. cattle VIRA SHIELD 6+L5 HB • Noncytpathic BVD Type 1 and 2, Cytopathic BVD Type 1 PI3, IBR, BRSV, L. canicola L. grippotyphosa, L. hardjo-bovis, L. icterohaemorrhagiae, L. pomona • Dosage: 5 mL, SubQ, revaccinate 4-5 weeks. Revaccinate annually • Convenient, broad-spectrum protection against up to 12 disease-causing organisms • Safe for use in pregnant cows and heifers VIRA SHIELD 6 • Noncytopathic (NCP) BVD Type 1, NCP BVD Type 2, and cytopathic BVD Type 1, IBR, PI3, BRSV • Dosage: 5 mL, SubQ, Revaccinate in 4-5 weeks. Revaccinate Annually • Long-lasting protection against Type 2 BVD ® REPROSTAR VL5 HB • L. hardjo bovis, L. canicola, L. grippotyphosa, L. icterohaemorrhagiae, L. pomona • Dosage: 2 mL, 2-4 weeks prior to breeding, IM, booster in 4–6 weeks with ReproSTAR L5 HB, revaccinate annually • Lepto hardjo-bovis component was isolated from a U.S. dairy experiencing poor conception rates MASTER GUARD® 10 HB • BVD, types 1 and 2, IBR, PI3, BRSV, L. canicola, L. grippotoyphosa, L. hardjo, L. icterohaemorrhagiae, L. Pomona and L. hardjo-bovis • Dosage: 3 mL, SubQ or IM, booster in 2-4 weeks with Master Guard 10 HB. Revaccinate annually. Calves vaccinated before weaning should be revaccinated 30 days after weaning • Approved for use in pregnant cows and nursing calves; may be used in calves at least 5 months of age • Unique combination of killed and MLV components that’s proven safe and effective against reproductive and respiratory disease, and protects against Lepto TITANIUM 5 L5 HB • BVD, types 1 and 2, IBR, PI3, BRSV, L. canicola, L. grippotoyphosa, L. hardjo, L. icterohaemorrhagiae, L. Pomona and L. hardjo-bovis • Dosage: 2 mL, SubQ, booster in 2-4 weeks with monovalent BRSV vaccine (Titanium® BRSV). Revaccinate annually. Calves vaccinated before weaning should be revaccinated 30 days after weaning. • Approved for use in pregnant cows and nursing calves • Broad, proven protection against respiratory and reproductive viruses, and Leptospira, at every stage of production Calf Diarrhea (Scours) SCOUR BOS 4 • Coronavirus and 3 types of rotavairus • Dosage: 2 ML dose, IM, 8-16 weeks prior to calving. Revaccinate 8-10 weeks prior to calving • For use in healthy pregnant cattle as an aid in prevention of disease in calves caused by bovine rotavirus and bovine coronavirus Pneumonia NUPLURA® PH • M. haemolytica • Dosage: 2 mL dose, SubQ, revaccinate annually • First and only cattle vaccine developed in the U.S. market using a combination of outer membrane protein and recombinant leukotoxoid technology Footrot FUSOGARD® • F. necrophorum • Dosage: 2 mL, SubQ, revaccinate in 3 weeks, revaccinate annually • An economical, proactive protection alternative to antibiotic treatment Pinkeye PINKEYE SHIELD® XT4 • Moraxella bovis • Dosage: 2 mL, IM, revaccinate annually • Contains four field isolates of M. bovis — a leading cause of pinkeye Clostridial (Blackleg) CLOSTRI SHIELD® 7 • C. chauvoei, C. septicum, C. novyi, C. sordellii, C. perfringens Types C and D • Dosage: 2 mL, SubQ, booster in 2-4 weeks, revaccinate annually • Proprietary dual-component adjuvant system CLOSTRIDIUM PERFRINGENS — TYPE A TOXOID • • • • C. perfringens Type A Dosage: 2 mL, SubQ, booster in 2-4 weeks, revaccinate annually First conditionally licensed C. perfringens Type A vaccine for cattle C. perfringens Type A, implicated in hemorrhagic bowel syndrome in cows — also deadly in calves and commonly isolated in cases where abomasal ulcers and hemorrhage are found SCOUR BOS® 9 • 3 types of rotavirus, coronavirus, 4 isolates of E. coli bacteria, C. perfringens Type C • Dosage: 2 mL dose, IM, 8-16 weeks prior to calving, revaccinate annually 8-10 weeks prior to calving, revaccinate with 2 mL booster dose of Scour Bos® 4 (rotavirus, coronavirus) at four weeks precalving in year one • Vaccinating pregnant cows helps build colostral antibodies that protect newborn calves from scours For all vaccine products: The label contains complete use information, including cautions and warnings. Always read, understand and follow the label and use directions. Elanco, Full Value Beef, Master Guard®, Titanium®, BRD Shield®, Clostri Shield®, Fusogard®, NUPLURA®, Pinkeye Shield®, Quick Shield®, ReproSTAR®, Scour Bos®, Somnu Shield®, Vira Shield® and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates. © 2015 Elanco Animal Health. NCH 34334-7 USBBUMUL01136