1.1.1.i.a - Fundamental knowledge and basic tools for functional
genomics in all organisms
These records were published on CORDIS and relate to the invitation to submit Expressions
of Interest (EoI) to use the new instruments (Integrated Projects and Networks of
Excellence) proposed for the Sixth RTD Framework Programme published in the Official
Journal OJ C 71 of 20 March 2002 and which closed on 7 June 2002.
"Functional Genomics and Proteomics of malignant melanoma"
Acronym :
melanoma genomics
Organisation:
Department of Dermatology
Contact person details
Title:
PD Dr. med.
Gender:
Family Name:
Kunz
First Name:
Address:
Department of Dermatology, University of Rostock,
Augustentsr. 80, 18055 Rostock, Germany
M
Manfred
Country:
Telephone N°:
E-mail:
493814949702
Germany
493814949708
Fax N°:
manfred.kunz@med.uni-rostock.de
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.b Combating cancer
Abstract:
Human malignant melanoma is a highly metastatic tumor of steadily increasing incidence
and poor prognosis after metastasis. Since current therapeutic approaches have not been
able to improve the overall prognosis of these patients a more profound understanding of
the melanoma pathogenesis is urgently needed. In the proposed research action recently
developed molecular biology analysis techniques such as gene chip technology and
proteomics technology will be applied to malignant melanoma. Results from these
analyses will then be validated in DNA vaccination studies and pharmacological studies
on cell signalling processes. The described approach will strenghten the european
competitiveness in the field of genome-based biomedical research for implementation
of new treatment strategies for cancer.
Additional document:
int_30024.doc
A candidate gene approach to study iron homeostasis dysregulations
Acronym :
irhodys
Organisation:
UMR-CNRS 6061
Contact person details
Title:
Prof
Gender:
Family Name:
MOSSER
First Name:
Address:
Faculté de Médecine
2, av. du Pr. Léon Bernard - CS34317
35043 RENNES CEDEX, France
Country:
France
Telephone N°:
+33(0)223234491
Fax N°:
E-mail:
jean.mosser@univ-rennes1.fr
M
Jean
+33(0)223234478
Applicable Instrument: Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Iron is essential for life, but its homeostasis is frequently disrupted, leading to iron deficiency or
overload. Primary iron overload or hemochromatosis, the most frequent inherited disease in
Europe, is mainly due to the C282Y mutation in the HFE1 gene. But the expression of this
mutation is very likely modulated by other gene variants not yet identified. Their characterization
needs to conduct two studies in parallel. One corresponds to a transcriptomic approach for
identification of candidate genes expressed in the intestine. We will focus on 2 types of models: the
CaCo-2 cell line and transgenic mice exclusively over expressing protein HFE in the intestine. The
parallel study will evaluate the clinical implication by analysing the gene haplotypes distribution in
different sets of normal or affected individuals originated from Brittany.
Additional document:
int_29646.doc
A high throughput approach to decipher the histone code
Acronym :
Histone Code
Organisation:
University of Ioannina
Contact person details
Title:
Prof
Gender:
M
Family Name:
Georgatos
First Name:
Spyros
Address:
Laboratory of Biology, Medical School, University of Ioannina, Ioannina 45110, Greece
Country:
Telephone N°:
E-mail:
Greece
30651097565
sgeorgat@cc.uoi.gr
Fax N°:
30651097863
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Patterns of post-translational modifications marking the N-terminal tails of histones have been
suggested to serve as an epigenetic, information code.
Deciphering the histone code is one of the greatest challenges in contemporary biology and a key
to far-reaching biotechnological and pharmaceutical applications.
Aiming at this target our consortium, which includes 32 European experts on peptide chemistry,
proteomics, functional genomics, structural biology, immunology, molecular, cell, and
developmental biology, proposes a multidisciplinary, high throughput approach.
The new approach involves modeling of the histone tails by sophisticated theoretical methods,
production or selection of anti-histone code antibodies from rationally designed, combinatorial
peptide libraries and banks of autoimmune sera, and use of these reagents to investigate gene
regulation in health and disease.
Additional document:
int_29285.doc
An integrated network for transgenic and mutant mouse pathology
Acronym :
EMpath
Organisation:
Dept. of Anatomy University of Cambridge
Contact person details
Title:
Dr.
Gender:
M
Family Name:
Schofield
First Name:
Paul
Address:
Dept. of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
Country:
Telephone N°:
E-mail:
United Kingdom
44-1223-333893
ps@mole.bio.cam.ac.uk
Fax N°:
44-1223-338056
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The mouse has become the primary animal model for the study of human genetic diseases and
other disorders. There is currently a basic lack of specialist competence in mouse pathology in
Europe which impacts severely on the effectiveness of research programmes using mutant mice.
The aim of the proposal is to address the lack of expertise in mouse pathology available to
laboratories within Europe and to integrate our knowledge of mutant mouse pathology with
genomic and other phenotypic data. This project pools European expertise in mouse pathology,
genetics and bioinformatics to set up a European Centre for Mouse Pathology. The activities of the
centre will be training courses in mouse pathology, diagnostic referral, and research workshops. In
addition the project will continue the curation and development of the Pathbase mutant mouse
pathlogy database and produce web resources for pathology.
Additional document:
int_29814.doc
Applying Multiple-Valued Logic (MVL) to Bioinformatics
Acronym :
MVL Multiple-Valued
Organisation:
Intelligent Systems Engineering Laboratory, at the University of Ulster
Contact person details
Title:
Prof
Gender:
M
Family Name:
McGinnity
First Name:
Martin
Address:
School of Computing and Intelligent Systems, University of Ulster,Northland Road, Londonderry,
Northern Ireland, BT48 7JL
Country:
Telephone N°:
E-mail:
United Kingdom
+44(0) 2871375417
tm.mcginnity@ulst.ac.uk
Fax N°:
+44(0) 2871375570
Applicable Instrument: Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
1.1.2.iii Components and microsystems
Abstract:
The four-valued nature of the genetic code makes it an obvious choice for applications of
four-valued logic. The existing techniques that are used in MVL can be modified and extended to
meet the new challenges of bioinformatics. MVL can mine genetic data in a search for rules and
relationships; and suggest structures that model natures own way closely so that the model can
achieve good predictability and give the bio-engineer better insights. The European community
should take the lead in bringing these two diverse disciplines together.
Additional document:
int_29720.doc
Basic and comparative aspects of gene regulation related to innate and adaptive immune responses
to virus infections: from fish genomics to host-pathogen interactions in man
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
PO Box 8146 Dep
N-0033 Oslo,
Norway
Country:
Telephone N°:
E-mail:
GENREGFISH
Norwegian School of Veterinary Science
Professor
Evensen
Gender:
First Name:
Norway
+47 2259 7106
Fax N°:
oystein.evensen@veths.no
M
Øystein
+47 2321 6101
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Bony fishes are the first groups of animals from an evolutionary point of view, where innate and
adaptive immune functions are involved in an integrated immune response. One of the most
frequently used model species in genome research in lower vertebrates is the zebra fish, also
recognised as a model in human genome research. This project will be a multidisciplinary
approach to functional genomics in commercially important fish species (salmon, trout, sea bass
and sea bream) and zebra fish using a virus infections as models to study basic biological processes
related to i) infection and responses to infection and to ii) biological processes related to innate and
adaptive immune responses focusing on the elucidation of the mechanisms underlying these
fundamental cellular processes. The key issue is to identify the genes/gene products involved in
defense against viruses and to decipher their biological functions in the living organism. This will
foster a basic understanding of fundamental processes in relation to health of animals and humans
as well as provide tools for development of efficient vaccines against important diseases of
aquacultured fish.
Additional document:
int_29478.pdf
Basic Helix-Loop-Helix Proteins: Crossroads of Development and Disease
Acronym :
bHLH-D&D
Organisation:
Flanders Interuniversity Institute for Biotechnology
Contact person details
Title:
Dr.
Gender:
M
Family Name:
HASSAN
First Name:
Bassem
Address:
Laboratory of Neurogenetics
Department of Human Genetics-VIB4
Flanders Interuniversity Institute for Biotechnology (VIB)
O&N 6, Herestraat 49, Gasthuisberg, KUL
3000 Leuven
Belgium
Country:
Telephone N°:
E-mail:
Belgium
3216346226
Fax N°:
Bassem.Hassan@med.kuleuven.ac.be
3216346218
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
Abstract:
Basic Helix-Loop-Helix proteins control the generation and differentiation of a large number of
cell types in many tissues including the nervous system, the heart and the gastrointestinal tract.
Their role as markers, potential causative agents and therap
Additional document:
int_30494.doc
Bio- and Nano- Technologies for Health
Acronym :
BIONTH
Organisation:
University of Abertay Dundee
Contact person details
Title:
Dr
Gender:
Family Name:
ADYA
First Name:
Address:
School of Contemporary Sciences
University of Abertay Dundee
Bell Street
Dundee DD1 1HG
Scotland (UK)
Country:
Telephone N°:
E-mail:
United Kingdom
+44-1382-308653
A.Adya@abertay.ac.uk
Fax N°:
M
Ashok
+44-1382-308663
Applicable Instrument: Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.3.i Nanotechnologies and Nanosciences
Abstract:
The concerted and integrated efforts of the network partners from diverse disciplines will be used
in an effective and complementary way to characterise and analyse the structure, function, stability,
chemical and mechanical properties, etc. of a wide variety of macromolecular biological systems,
such as proteins, DNA/RNA, biomolecular complexes, living cells, etc., in vivo and in vitro, under
different environmental and physiological conditions by using different techniques, such as atomic
force microscopy, scanning electron microscopy, neutron fibre diffraction, neutron and X-ray
reflection, ellipsometry, modelling, etc. The information obtained will be used (i) to advance and
further strengthen the knowledge base in the ERA, (ii) to develop new devices based on biosensors,
and nano-systems, such as, those for telecare, telehealth, etc., and (iii) to develop new
biocompatible materials for use in biomedicine, etc.
Additional document:
int_29211.doc
BioInformatics Tools to Optimise Prediction and Integrative Analysis for Functional Genomics
Acronym :
BITOPIA-FUGE
Organisation:
National Institute for Medical Research
Contact person details
Title:
Dr
Gender:
M
Family Name:
Heringa
First Name:
Jakob (Jaap)
Address:
Division of Mathematical Biology, National Institute for Medical Research, The Ridgeway, Mill
Hill, London NW7 1AA, UK
Country:
Telephone N°:
E-mail:
United Kingdom
442088162293
Fax N°:
jhering@nimr.mrc.ac.uk
442088162460
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.2.ii Communication, computing and software technologies
Abstract:
We propose to construct an integrated bioinformatics software suite for functional genomics. The
suite aims to improve the discovery cycle from genomic
sequence data to protein network functionality, relevant for Biotechnological, Pharmaceutical and
Medical research. The project involves high-level integration
of bioinformatics tools for DNA/protein sequence data, protein 3-dimensional data, gene
expression (microarray) data, and metabolic/signalling pathway data.
The tools will be intertwined to integrate the biological information brought about by the various
methods in order to optimise the functional interpretation
over all data sources. The software suite will also be fully integrated with parallelised/distributed
computing and the latest World Wide Web technologies.
Additional document:
int_29860.doc
BIOTECH APPLICATIONS FROM FUNCTIONAL GENOMICS AND PROTEOMICS OF
RHIZOSPHERE MICROORGANISMS
Acronym :
RHIZOTECH
Organisation:
NEWBIOTECHNIC, S.A.
Contact person details
Title:
Mr
Gender:
Family Name:
Camacho Fumanal
First Name:
Address:
Av. Américo Vespucio,69 – local 3
Parque Científico y Tecnológico “Isla de la Cartuja”
41092 Sevilla
Country:
Spain
Telephone N°:
+34 954081031
Fax N°:
E-mail:
fumanal@newbiotechnic.com
M
Rafael
+34 954081034
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6 Sustainable development, global change and ecosystems
Abstract:
The objective of this INTEGRATED PROJECT is to develop post-genomic tools and to use them
in the identification of genes and gene products from rhizosphere microbial biodiversity, with a
specific focus on the interaction between plants and biocontrol bacterial and fungal strains of
biotechnological value, to assess their industrial potential in five separate sectors: 1) Agriculture, 2)
Industrial enzymes, 3) Environmental protection, 4) Food industry, and 5) Medicine;, and to
exploit and commercialise them in concert with EU biotechnology strategies.
Additional document:
int_36366.pdf
Brain Databases: Enabling the Transition from Genomics to Brain Function
Acronym :
BrainDB
Organisation:
University of Oslo, Oslo, Norway
Contact person details
Title:
Professor
Gender:
Family Name:
Bjaalie
First Name:
Address:
Neural Systems and Graphics Computing Laboratory,
Institute of Basic Medical Sciences, Department of Anatomy
University of Oslo
P.O. Box 1105 Blindern
N-0317 Oslo, Norway
Country:
Norway
Telephone N°:
4791787901
Fax N°:
E-mail:
j.g.bjaalie@basalmed.uio.no
M
Jan G.
4722851045
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
1.1.2.i Applied IST research addressing major societal and economic challenges
Abstract:
In order to understand the functions and dysfunctions of the brain, there is a need to integrate many
levels of description, ranging from molecule and gene, cell and synapse, to perception, cognition
and behavior. Progress cannot only be achieved by the continued collection of more data,
published in hundreds of journals, and integrated via conventional publication formats. The
construction of data and knowledge management systems for multiple levels of neuroscience data,
together with advanced analytical tools, will be a necessity to achieve this integration. The
proposed NoE will seek to structure and integrate brain databasing efforts in Europe, and to inform
and influence the community of scientists to gradually make use of novel opportunities offered by
electronic information and communication systems.
Additional document:
int_29884.doc
Cellular Signalling and Protein Phosphorylation Network
Acronym :
Cell Signalling NoE
Organisation:
University of Oslo
Contact person details
Title:
Professor, M.D., Ph.D.
Gender:
M
Family Name:
Taskén
First Name:
Kjetil
Address:
Department of Medical Biochemistry, Institute of Basic Medical Sciences,and Norwegian
Research Council Medicine and Health Group for Signal Transduction in Health and Disease,
University of Oslo, P.O.B. 1112, Blindern, N-0317 Oslo, Norway
Country:
Norway
Telephone N°:
47-22851454
Fax N°:
47-22851497
E-mail:
kjetil.tasken@basalmed.uio.no
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Over 20% of the human genome encodes proteins that are devoted to cellular signalling,
illustrating the importance of these regulatory processes that are pivotal to normal cell functioning
and often are perturbed in disease. Signalling networks involving protein phosphorylation are
involved in major chronic diseases within the European Community such as cancer, cardiovascular
disease, type II diabetes, asthma, infectious diseases such as HIV and also underpins various
genetic diseases. By combining complementary expertise held by key institutes across the EU we
will co-ordinate a joint effort to understand complex and integrated intracellular signalling with the
focus to elucidate basic molecular mechansims to provide novel approaches for development of
therapeutic and diagnostic reagents. Highly competitive and major tasks leading to novel insights
will be solved.
Additional document:
int_36703.doc
Characterization and Sex Determination in Pistacia Species
Acronym :
PMB
Organisation:
University of Cukurova, Faculty of Agriculture
Contact person details
Title:
Assoc.Prof.
Gender:
M
Family Name:
KAFKAS
First Name:
Salih
Address:
University of Cukurova Faculty of Agriculture Department of Horticulture
Country:
Telephone N°:
E-mail:
Turkey
+90 322 338 63 88
skafkas@mail.cu.edu.tr
Fax N°:
+90 322 338 63 88
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6.3 Global Change and ecosystems
Abstract:
There are more than 100 P. vera cultivars and more than 10 Pistacia species. There are several
molecular phylogenetic and cytological studies in Pistacia and the results need to be confirmed.
Therefore, the first aim in this project will be clarification of relationships between Pistacia species
and P. vera cultivars by several molecular markers and characterization of chromosomes of
Pistacia species by counting and karyotyping. The sex habit of the genus is dioecious and
juvenility period is long (5-8 years). The sex mechanism is still unknown in Pistacia. Therefore, the
other aim of this project will be screening of sex genes in Pistacia. Besides rootstock material, the
nuts of the wild Pistacia species are also used for oil production by local growers. Therefore, it is
necessary to test the quality of this organic oil for human health and compare with the commercial
ones. Thus, the objectives of this project are to characterize Pistacia germplasm at molecular and
cytological level and to find genes linked to sex and to understand sex mechanism in pistachio, and
to evaluate wild Pistacia oil at commercial level
Additional document:
int_38464.doc
Circadian rhythms in the nervous system of Drosophila melanogaster and their analysis by genetic
means
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Ingardena 6
30-60 Krakow
Poland
Country:
Telephone N°:
E-mail:
Biological rhythms
Jagiellonian University, Institute of Zoology, Department of Cytology and
Histology
Dr
Pyza
Gender:
First Name:
F
Elzbieta
Poland
48126336377
pyza@zuk.iz.uj.edu.pl
Fax N°:
48126344951
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Circadian rhythms are biological rhythms which have a period about 24 h and are expressed in
behavioural, physiological and biochemical processes in all organisms. They are generated by
internal oscillators called circadian clocks and entrained to daily changes of the day and night by
light. The fruit fly Drosophila melanogaster was a first organism in which the first clock gene,
period, was discovered and still Drosophila as a major model to study the circadian rhythms and
the molecular mechanism of the clock. In the visual system of Drosophila and other fly species we
have found that frequency of synaptic contacts and shape and size of some neurons are controlled
by the circadian clock. Using Drosphila mutants and transgenic lines we propose to study the
function and mechanism of circadian rhythms in neuronal plasticity their significance for a normal
activity of the visual system.
Additional document: int_29804.doc
Comparative Genomics of Filamentous Fungi
Acronym :
FUNGINOMICS
Organisation:
Institut National de la Recherche Agronomique (INRA)
Contact person details
Title:
Dr
Gender:
M
Family Name:
Rouxel
First Name:
Thierry
Address:
INRA-PMDV, Route de St Cyr
78026 Versailles Cedex, France
Country:
Telephone N°:
E-mail:
France
33130833229
Fax N°:
rouxel@versailles.inra.fr
33 1 30 83 31 95
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6.3 Global Change and ecosystems
Abstract:
Fungi are of primary medical, agricultural, ecological, biotechnological and economic importance,
recently leading the USA and EU to launch major whole-genome sequencing initiatives. The aim
of the FUNGINOMICS network is to take advantage of the availabil
Additional document:
int_29943.doc
Comparative genomics of recombination and DNA damage repair systems
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Carl-von-Linne-Weg 10
D-50829 Koeln, Germany
ComRec
Max-Planck-Institut fuer Zuechtungsforschung
Country:
Telephone N°:
E-mail:
Germany
492215062220
Fax N°:
reiss@mpiz-koeln.mpg.de
Dr.
Reiss
Gender:
First Name:
M
Bernd
49 221 5062213
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Processes determining genome stability, like DNA replication, DNA recombination, DNA damage
and mismatch repair are basic biological processes with conservation between organisms. Yet they
play different roles in the development and live of different orga
Additional document:
int_28925.doc
Comparative Transcriptome/Proteome Analysis in Mouse Models.
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Ingolstaedter Landstr.1
85764 Neuherberg
Germany
Country:
Telephone N°:
E-mail:
ECoTraMP
GSF - National Research Centre for Environment and Health
Dr.
Beckers
Gender:
First Name:
M
Johannes
Germany
498931873513
beckers@gsf.de
Fax N°:
498931873500
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
Abstract:
The aim of the proposal is to establish a European Integrated Project to understand molecular
regulatory networks underlying disease. The generation of such basic knowledge is a requirement
for selective and targeted therapy. The ECoTraMP consortium (European Consortium for
Comparative Transcriptome and Proteome Analysis in Mouse Models) will combine a critical mass
of European expertise in mouse genetics, gene expression analysis, and bioinformatics in a
multidisciplinary approach. The consortium will establish Europe as international leader in the
molecular analysis of disease models by the year 2008.
Additional document:
Not available
Complex Metal-Containing Cofactors
Acronym :
CoMeCo
Organisation:
The CoMeCo consortium
Contact person details
Title:
Dr.
Gender:
Family Name:
Hansson
First Name:
Address:
Department of Biochemistry, Lund University, Box 124,
22100 Lund, Sweden
Country:
Sweden
Telephone N°:
46462220105
Fax N°:
E-mail:
mats.hansson@biokem.lu.se
M
Mats
46462224534
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
Abstract:
Approximatelly 40% of all biochemical reactions in the cell involve a metal ion. Very often the
metal ion is tied to an organic molecule, forming a complex metal-containing cofactor.
Examples are heme (with bound Fe), vitamin B12 (Co), chlorophyll (Mg) and coenzyme F430
(Ni). The aim of this proposal is to coordinate the European scientific expertise in the research
of these cofactors. The consortium covers most techniques within functional genomic research.
The integration is expected to provide the basic knowledge for under-standing the molecular
mechanisms of cofactor biosynthesis and incorporation of these cofactors into proteins, as
well as the understanding of diseases associated with disorders in these processes. Further,
the project will have applications in clinical improvments of cancer therapy, in developing new
antimicrobial agents and in fighting malaria.
Additional document:
int_29740.pdf
Computational Biology - Network of Excellence
Acronym :
Organisation:
COMBINE
Max-Planck-Gesellschaft z.F.d.W.represented byMax-Planck-Institut für
Informatik
Contact person details
Title:
Prof. Dr. Ph.D.
Family Name:
Lengauer
Address:
Stuhlsatzenhausweg 85
66123 Saarbrücken
Germany
Country:
Telephone N°:
E-mail:
Germany
496819325300
lengauer@mpi-sb.mpg.de
Gender:
First Name:
M
Thomas
Fax N°:
496819325399
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.2.iv Knowledge and interface technologies
Abstract:
This network will bundle and expand Europe's competence in the algorithmic and statistical part of
computational biology. The network is carried through by 10 founding partners. 15 associated
partners broaden the research expertise of the network and also
Additional document: int_29914.pdf
Computational tools for large and small scale structure of genomes
Acronym :
GenomeScape
Organisation:
University of Helsinki
Contact person details
Title:
Prof.
Family Name:
Mannila
Address:
HIIT Basic Research Unit
Department of Computer Science, PO Box 26,
FIN-00014 University of Helsinki
Country:
Telephone N°:
E-mail:
Gender:
First Name:
Finland
358919144254
Fax N°:
Heikki.Mannila@cs.helsinki.fi
M
Heikki
358919144441
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.2.i Applied IST research addressing major societal and economic challenges
Abstract:
The GenomeScape integrated project will develop computational techniques and tools for the
analysis of large (genome-wide) and small-scale structure of genomes. The project will develop
tools for hierarchical description of haplotype structures, methods for analyzing rearrangements
and other segment structure of genomes, and structure-based tools for gene mapping. The
techniques will be based on modern data mining and statistical approaches. The consortium
consists of high-quality research groups in bioinformatics and computational biology, and groups
working in biological data production and analysis.
Additional document:
Not available
Coordinating Cell growth, Cell number and Differentiation
Acronym :
Organisation:
GrowDiffer
Institut de Génétique Moleculaire de Montpellier (IGMM) UMR
5535CNRS/Université Montpellier II
Contact person details
Title:
Dr
Family Name:
Gandarillas
Address:
IGMM, CNRS. 1919 Route de Mende.
34293 Montpellier Cedex 5
France
Country:
France
Telephone N°:
33 (0)467 613649
E-mail:
agandari@igm.cnrs-mop.fr
Gender:
First Name:
M
Alberto
Fax N°:
33 (0)467 040231
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The co-ordination of cell growth and differentiation is crucial to tissue homeostasis and disease,
but it has been poorly studied in a physiological context, especially in mammalian organisms. The
GrowthDiffer focus is to use and develop models to study growth on tissue, organ and organism
levels to explore: 1. how cells communicate to co-ordinate their growth; 2. what are the targets of
these signalling pathways, 3. how growth and cell division are coupled to cell differentiation, 4.
how endoreplication, a special cell cycle, contribute to growth and differentiation. Our integrative
project employs genomic information, genetics, functional genomics, proteomics and microarray
tools on conserved growth-regulatory pathways in distantly related or separately evolved
organisms. The generated knowledge will set novel basis for diagnostic and therapeutic strategies
on diseases related to malfunctions in growth, such as cancer, muscle atrophy, nerve damage or
diabetes.
Additional document:
int_30475.doc
Creatine in the brain: molecular, experimental, clinical and therapeutical aspects
Acronym :
Brain creatine
Organisation:
IRCCS Fondazione Stella Maris
Contact person details
Title:
Prof.
Gender:
Family Name:
Cioni
First Name:
Address:
Viale del Tirreno, 331, 56018 Calambrone, Pisa, Italy
Country:
Italy
Telephone N°:
39050886283
Fax N°:
E-mail:
gcioni@inpe.unipi.it
M
Giovanni
39050886247
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Abstract:
Genetic defects of creatine (Cr) synthesis or transport have been discovered. They cause severe
brain disorders, at least partially reversible by oral Cr supplementation, thus demonstrating that Cr
is necessary for normal brain functioning. Moreover, Cr administration has been reported to protect
against neurodegenerative diseases, stroke and muscular distrophy. We will: 1) develop cellular
and animal models to study the function of Cr in the brain; 2) characterize the role of the genes
(GAMT, AGAT; CT1) involved in inherited Cr deficiency syndromes and study their
genotype/phenotype correlations; 3) identify the frequency of their mutations and polymorphisms
in various European populations; 4) develop new technologies for pre- and post-natal diagnosis of
Cr deficiency syndromes; 5) investigate Cr as a neurotherapeutic drug; 6) develop new Cr-derived
drugs.
Additional document:
int_29767.doc
Cytochrome P450 as a biomarker of human susceptibility to chemical toxicity
Acronym :
CYP - MARKER
Organisation:
UNIVERSITY OF PADUA, ITALY
Contact person details
Title:
Dr.
Gender:
M
Family Name:
MANNO
First Name:
MAURIZIO
Address:
DEPARTMENT OF ENVIRONMENTAL MEDICINE AND PUBLIC HEALTH
Via Giustiniani, 2
35128 Padua, Italy
Country:
Telephone N°:
E-mail:
Italy
390498218855
manno@unipd.it
Fax N°:
390498212542
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
The proposal is based on the scientific hypothesis that individual susceptibility to the toxic effects
of many environmental/occupational chemicals is multifactural and depends a great deal on both
genetic and environmental factors, and more particularly on their interaction. Therefore, we
propose to: a)develop and validate new rational, specific and sensitive biomarkers capable of
predicting, on an individual basis, the human susceptibility to the toxicity of chemicals used
occupationally, environmentally and clinically; b) improve quantitative risk assesment of
chemicals by replacing the traditional methodologies, currently based on indiscriminate toxicity
testing, extensive use of laboratory animals and recruitment of the so-called"safety" factors with in
vitro tests. These objectives will be achieved through the collaboration of a number of academic
institutions and biotechnology industries offering both basic and clinical competence, each with a
considerable expertise on a specific research area related to the proposed objectives.
Additional document:
int_29605.doc
Data Management Tools for Bioinformatics: Algorithms, Systems and Applications
Acronym :
BIOMOD
Organisation:
University of Ioannina
Contact person details
Title:
Assistant Professor
Family Name:
Fudos
Address:
Department of Computer Science,
University of Ioannina
PO BOX 1186
Panepistimioupoli Ioanninon,
GR 45110 Ioannina, Greece
Country:
Greece
Telephone N°:
+30-6510-98805
E-mail:
fudos@cs.uoi.gr
Gender:
First Name:
M
Ioannis
Fax N°:
+30-6510-98890
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.ii Combating major diseases
Abstract:
The aim of the proposed project is to locate and identify human genes conferring resistance to
humans against bacterial, fungal and viral pathogens, and genes involved in human – pathogen
interactions in general. To this end, an “in silica reverse genetics” approach will be developed,
based on currently existing knowledge and databases. The first step of this approach will exploit
existing databases of amino acid sequence motifs, involved in protein – protein interactions, and
will generate a specific database of such proteins/motifs involved in host - pathogen interactions.
This database will include every known host – pathogen data, regardless of their organismic nature
(e.g. such as plant – plant pathogenic microbes). The motifs will be “reverse translated” into every
possible DNA sequence and each sequence will be used as a probe to search the human genome
database for identical and/or similar sequences.
New methods for indexing and retrieval of amino sequences as well as 3D structures will be
developed to support these processes.
Additional document:
Not available
DE-ORPHANIZING G-PROTEIN-COUPLED RECEPTORS AND DISCLOSING NOVEL
PUTATIVE P2Y RECEPTORS
Acronym :
DISCOVER-P2Y
Organisation:
Universita' degli Studi di Milano (University of Milan),Italy
Contact person details
Title:
Associate Professor
Gender:
F
Family Name:
ABBRACCHIO
First Name:
MARIAPIA
Address:
Department of Pharmacological Sciences, via Balzaretti 9 -20133 Milan, ITALY
Country:
Telephone N°:
E-mail:
Italy
+39-02-50318310
Fax N°:
Mariapia.Abbracchio@unimi.it
+39-02-50318284
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Several cloned "orphan" GPCRs may represent yet-uncharacterized P2Y receptors responding to
purine and pyrimidine nucleotides. The project aims at cloning these receptors from human tissues,
functionally characterize them, synthetize selective agonist/antagonist ligands, and gain
information on the distribution and pathophysiological roles of the new receptors.
Tissues from both healthy subjects and diseased patients (e.g., with cancer or neuro-immune
diseases) will be utilized.The "deorphanization" of new putative P2Y receptors may disclose
biological targets for the development of novel therapeutic strategies to major currently incurable
human diseases. The aggregation of 9 qualified european groups will enable the
project to become internationally competive in this area of research and guarantee the achievement
of the desired objectives in due time.
Additional document:
int_30171.doc
Diversity and epidemiology of plant viruses
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Zaliuju ezeru 49,
Vilnius LT-2021, Lithuania
EPIDIPLAVIRUS
Institute of Botany
Country:
Telephone N°:
E-mail:
Lithuania
37022729838
Fax N°:
juozas.staniulis@botanika.lt
Dr. Habil.
Staniulis
Gender:
First Name:
M
Juozas
37022729950
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6 Sustainable development, global change and ecosystems
Abstract:
Knowledge of virus biology, epidemiology, virus-host and virus-vector interactions is prerequisite
for disease management. Increased exange and movement of plant material among EC countries
and necessity to gain knowledge about virus epidemiological situation in all climatic and
ecological regions of EC encaurages close collaboration of plant virologists within the EU.
Appearance of new and mutation of mild virus strains and their unexpected spread can cause
potential problems. Virologists of separate countries can't overcome such threat. Only local
precausion measures hardly can be effective. This implies that along with network of exellence in
EU should be created integrated projects, which would also include regional units of plant
virology, competent enough to carry out research on virus detection, identification, spread, ecology
using modern technique and capable for close international co-operation.
Additional document:
int_30868.doc
DYNAMICS OF MOLECULAR MACHINERY:FROM MECHANISM TO CELL PHYSIOLOGY
Acronym :
DYNACELL
Organisation:
Ecole PolytechniqueINSERM U451 - CNRS UMR 7645
Contact person details
Title:
Professor
Gender:
M
Family Name:
MARTIN
First Name:
Jean-Louis
Address:
Laboratory for Optics and BiosciencesINSERM U451 - CNRS UMR 7645Ecole
Polytechnique-ENSTA91128 PALAISEAU CEDEX France
Country:
France
Telephone N°:
331 69 33 41 24
Fax N°:
33 1 69 33 30 17
E-mail:
jean-louis.martin@polytechnique.fr
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.3 Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new
production processes and devices
1.1.3.i Nanotechnologies and Nanosciences
Abstract:
The fundamental challenge of this Network of Excellence is to bridge the gap between the
understanding of molecular machines and the behaviour of intact cells. This theme will generate a
new paradigm for biology, i.e., nanophysiology. It will pave the way for a rational site-directed
pharmacology with predictable impact of drugs on the whole cell physiology and ultimately on
organs and organisms. Understanding the functioning of the cell requires bringing together the
whole range of expertise from optics, femtosecond dynamics and novel microscopy techniques to
protein crystallography, protein engineering and cell physiology. This is what this network
proposes to do on a European level. Going beyond experimentation and data collection, the key
elements of the Network are the databasing of the molecular circuitry within a cell and the
integration through computational modeling
Additional document:
int_29648.doc
Energy-dissipating membrane proteins : a challenge for life and health
Acronym :
Edissip
Organisation:
University of Liege
Contact person details
Title:
Professor
Gender:
M
Family Name:
Sluse
First Name:
Francis
Address:
Allée de la chimie, Institut de Chimie, Bât. B6c, ULg, Sart Tilman, 4000 Liège, Belgium
Country:
Belgium
Telephone N°:
0032 4 366 35 87
Fax N°:
0032 4 366 28 78
E-mail:
F.Sluse@ulg.ac.be
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.c Confronting the major communicable diseases linked to poverty
Abstract:
In mitochondria, two pathways are opposing : a "conservating" part, the mitochondrial respiratory
chain which generates energy, and a "dissipating" part, which prevents energy production.
Dynamic equilibrium between these two systems is the cornerstone of the cell's energetic balance
and this is the reason why it is very important to understand these processes at any level of
complexity. The dissipating versant is mainly composed by two membrane proteins acting at two
different levels of the energy transduction : uncoupling proteins (UCP) and alternative oxidases
(AOX). As they are strong energy regulators, UCPs play a major role in energy consumption and
are involved in several human pathologies such as hyperinsulinemia and obesity. AOXs, that are
not present in mammals, are putative targets for drugs against Plasmodium (Malaria) and various
infectious microorganisms.
Additional document:
int_37924.doc
Engineering of animal models by renal-specific gene targeting
Acronym :
RSGT
Organisation:
UMR-CNRS 6548 University of Nice-Sophia Antipolis
Contact person details
Title:
Dr
Gender:
M
Family Name:
Poujeol
First Name:
Philippe
Address:
UMR-CNRS 6548 Université de Nice-Sophia Antipolis
Parc Valrose, 06108 Nice Cedex 2, France
Country:
Telephone N°:
E-mail:
France
33492076852
Fax N°:
poujeol@unice.fr; tauc@unice.fr
33492076850
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
Abstract:
The aim of the present EoI is to create and to investigate pathophysiological models of renal
function obtained by manipulating the mouse embryos via the transgenic technology.
Additional document:
int_29896.doc
EPIGENETIC PLASTICITY OF THE GENOME
Acronym :
Organisation:
'The Epigenome'
Research Institute of Molecular Pathology (IMP)A-1030 Vienna,
AUSTRIA
Contact person details
Title:
Dr.
Gender:
Family Name:
JENUWEIN
First Name:
Address:
Research Institute of Molecular Pathology (IMP)
Dr. Bohrgasse 7
A-1030 Vienna, AUSTRIA
Country:
Austria
Telephone N°:
+43-1-797-30-474
Fax N°:
E-mail:
jenuwein@nt.imp.univie.ac.at
M
Thomas
+43-1-798-7153
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Since the discoveries of Mendel, Flemming, Boveri and others, Europe has been a world leader in
genetic and chromosome research. The significance of these early findings has become even
greater following the nearly full sequence description of many eukaryotic genomes, including the
human genome. "We are more than the sum of our genes", and have just entered a ‘post-genomic’
era that promises to reveal more clearly the molecular basis of our identity. One genome can
generate many - epigenomes -, as the fertilised egg progresses through development and generates
a multitude of cell fates. In the proposed NoE, = 15 leaders will form a 'virtual core center' to focus
on molecular mechanisms of modern epigenetic research. This NoE will be extended with teams
primarily comprising young talent to build a coherent European Research Area of the
primarily comprising young talent to build a coherent European Research Area of the
‘epigenome’.
Additional document: int_29839.doc
EU Programme for Rat Functional and Comparative Genomics
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
2 rue Gaston Crémieux
CP 5721
91057 EVRY Cedex
France
EURATOMIC
CENTRE NATIONAL DE GENOTYPAGE
Country:
Telephone N°:
E-mail:
France
33160878403
Fax N°:
mark.lathrop@cng.fr
Prof.
LATHROP
Gender:
First Name:
M
Mark
33160878484
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Leading European groups in rat physiology, clinical investigations, genetics, genomics and
bioinformatics will undertake an integrated project to identify the major susceptibility
genes in the rat for disorders such as diabetes, stroke, hypertension, etc. for which this
species provides the most relevant models. The functional consequences of these genes
will be established by several experimental strategies, including investigations in wellcharacterised clinical samples for human disease already collected by consortium members.
Phenotying methodologies, rat gene targetting, and other technologies will be developed to
extend the range of exploratory techniques and models available. New genomic resources,
such as full-length cDNAs, created within this programme, will have a major impact on
comparative genomics and genome annotation in general.
Additional document:
Not available
European Chemoinformatics Network
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Toernooiveld 1
NL - 6525 ED Nijmegen
The Netherlands
Country:
Telephone N°:
E-mail:
Chemoinformatics
KUN (University of Nijmegen)
Prof. dr.
Buydens
Gender:
First Name:
F
Lutgarde
Netherlands
+31 24 3653192/3180
L.Buydens@sci.kun.nl
Fax N°:
+31 24 3652653
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
Within the field of drug discovery and the understanding of the working mechanism from gene to
drug (molecules), the domain and expertise of chemoinformatics is the analysis of small molecules,
their properties, interactions, and reactions. Research in Chemoinformatics encompasses
fundamental and applied research in the field of chemometrics, structure-activity relationships,
drug-receptor interaction, design and mining of (bio)chemical databases and metabolomics.
Chemoinformatics is grown out of different subdisciplines, e.g. chemometrics, computer
chemistry. The major bottleneck at this moment is the difficult communication due to differences
in computer and software systems and in terminology. Therefore this project proposes to create a
network of leading European expertise to overcome these barriers and boosting in this way
chemoinformatics research.
Additional document:
int_29046.doc
European CoHOrts to study vascular Genetics from Infancy network.
Acronym :
‘ECHOGENI’
Clinical Epidemiology and Endocrine Sciences Groups, Manchester
Organisation:
University Medical School, Manchester, UK.
Contact person details
Title:
Dr.
Gender:
M
Family Name:
Cruickshank
First Name: Kennedy
Address:
Director, Clinical Epidemiology Group, Unit of Chronic Disease Epidemiology, Manchester
University Medical School, Manchester M13 9PT, UK.
Country:
United Kingdom
Telephone N°:
441612755199/5211
Fax N°:
441612755208/5205
E-mail:
clinep@man.ac.uk
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
This Integrated Project will study interaction of genetic factors with environmental triggers in the
early evolution of cardiovascular (CVS) disease & diabetes. We will build & maintain a European
network of infant cohorts of over15,000 neonates & parents, to study CVS development
longitudinally through infancy to early childhood & in parental follow-up. We will integrate
genetic, molecular & epidemiological research across our network to examine genomic variation of
growth factor and vascular hormone systems within and across the cohorts. Variation in gene
expression, measured by peptide/ protein products in plasma at different growth stages /ages, of
insulin- and other vascular growth factor systems renin-angiotensin and other hormones, will be
related to vascular outcomes of blood pressure, aortic pulse wave velocity, left ventricular mass
and glycosylated haemoglobin.
Additional
Not available
document:
European Collaboration on Environment, Genes and Suicide
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Trubarjeva 2
1000 Ljubljana
Slovenia
Country:
Telephone N°:
E-mail:
SuicideLess Europe
Institute of Public Health of the Republic of Slovenia
Dr.
Marušic
Gender:
First Name:
Slovenia
+ 386 1 2441 402
Fax N°:
Andrej.marusic@ivz-rs.si
M
Andrej
+386 1 2441 447
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
Abstract:
In many European countries suicide is the cause of a significant proportion of total mortality. We
will perform an integrated research (traditional, molecular genetic and neuroimaging) accross
suicidal behaviour, from medically serious suicide attempts to completed suicide, to identify
common and risk factors. By doing so, we will create a scientific consortium with a strong
component of European added value, with access to a large DNA sample collection, with uniform
clinical information, for genetic analysis. Results will be used to create an integrated model of
genetic and environmental risk factors for suicidal behaviour, which will have implications for
behavioral treatments, pharmacological treatments and the development of an overall model of
suicidal behaviour aetiology.
Additional document:
int_29317.doc
European Community Osteoarthritis Research Alliancefor validated drug targets and tissue implants
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
M.E. Muller Institute
Murtenstrasse 35
P.O. Box 30
CH-3010 Bern
Switzerland
Country:
Telephone N°:
E-mail:
ECORA
University of Bern
Prof.
Trueb
Gender:
First Name:
Switzerland
+41 31 632 8726
Fax N°:
beat.trueb@mem.unibe.ch
M
Beat
+41 31 632 4963
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The aims of the Integrated Project ECORA are: 1) establish Europe as a world leader in strategic
research on osteoarthritis, and 2) translate the generated knowledge into applications by industrial
parties and health organizations.
Integration Activities comprise: integration of the European expertise in osteoarthritis, active
dissemination of the results, translation of strategic research into applications from companies).
Research Activities: deliverables from genomics, proteomics, and metabolomics (combined into
‘systems biology’), matrix biology, and monitoring techniques are: validated targets for
development of new drugs, engineered tissue for tissue replacement, diagnostic tools, relevant in
vivo and in vitro models to validate new drug targets and to test new drug candidates and
engineered tissue implants.
Additional document:
Not available
European Critical Care Research Network: integrating science, education, patient care.
Acronym :
ECCRN
Organisation:
European Society of Intensive Care Medicine
Contact person details
Title:
Dr
Gender:
M
Family Name:
Bion
First Name:
Julian
Address:
ESICM, 40 Avenue Wybran, B-1070 Brussels, Belgium
Country:
Belgium
Telephone N°:
+32.2/559.03.50
Fax N°:
+32.2/527.00.62
E-mail:
Public@esicm.org
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
An increasing proportion of health care budgets is spent on intensive care and critically ill patients.
Progress in understanding the causes and methods of prevention of critical illness has been slow.
We propose to develop a European critical care research network to integrate laboratory and
clinical research with bedside care and education to improve patient-centred outcomes. Focussing
initially on sepsis genetics, we will proceed to examine a range of interventions using large scale
studies involving as many intensive care units as possible to enhance generalisability and to
explore the effects of organisational variation. The network will include clinical, scientific and
industrial partners, and will integrate national projects through the development of common core
datasets.
Additional document:
int_29138.doc
European Epidermal Biology Research Initiative (EEBRI)
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Department of Virology
University of Heidelberg
INF 324
69120 Heidelberg
Country:
Telephone N°:
E-mail:
University of Heidelberg, Department of Virology
PD
Bugert
Gender:
First Name:
Germany
496221565007
Fax N°:
joachim_bugert@med.uni-heidelberg.de
M
Joachim J.
496221565003
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
Abstract:
The goal of this project is to implement a European epidermal biology network, that includes all
aspects of epidermal research from genome information to health care and biotech industry
applications. This integrated project would make Europe a leader in skin research. To achieve that
goal the European Epidermal Biology Research Initiative (EEBRI) is envisioned as a
multidisciplinary group of investigators, integrating already established networks of research
institutions, health care providers and biotech industries of different European countries. The
investigators share a commitment to advancing the understanding of the development of normal
epidermis and skin and aim to develop applications for diagnosis and treatment of a variety of
related skin diseases.
Additional document:
int_29319.txt
European Excellence Network on Genetic Deafness
Acronym :
DEAFNET
Organisation:
Amplifon s.p.a. -Centre forResearch and Studies Amplifon
Contact person details
Title:
Dr.
Gender:
M
Family Name:
Rollier
First Name:
Giovanni Martino
Address:
via Ripamonti 133, Milano - Italy
Country:
Telephone N°:
E-mail:
Italy
(39-02)57472373
rollier@amplifon.it
Fax N°:
(39-02)57409594
Applicable Instrument: Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.3 Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new
production processes and devices
Abstract:
The Network is aimed at structuring and integrating efforts of EU research, strengthening and
spreading the scientific and technological excellence in the area of genomics and its applications to
genetic hearing impairments. This will be achieved by networking together at EU level (I, F, UK,
E, NO, SE, DK, CH, FI, IL, NL) 500 researchers and expertise, integrating basic science, clinical
research, knowlegde management and nanotechnology applications, through a multidisciplinary
approach involving genetics, biochemistry, cell biology, epidemiology, medical statistics, ENT
surgery, audiology, physiology and pharmacology. Common use of a network of facilities
(infrastructures, equipment, database), joint training and exchange of personnel will constitute the
structure of the network.
Additional document:
int_29346.doc
EUROPEAN FUNCTIONAL ONCOGENOMICS: EXPLORING BIOLOGICAL FUNCTIONS
OF CANCER-RELATED GENES
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Strada. Prov. 142, km 3.95
10060 Candiolo (TO)
ITALY
EuroFOG
Institute for Cancer Research and Treatment (IRCC)
Prof.
Comoglio
Gender:
First Name:
M
Paolo M.
Country:
Telephone N°:
E-mail:
Italy
390119933601
enzo.medico@ircc.it
Fax N°:
390119933225
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The present project aims at developing and spreading technology for large-scale gene functional
analysis, with an initial focus on basic processes involved in cancer metastasis. Towards this aim,
participating Units will integrate world-recognised competences to implement six activities: (1)
Candidate gene generation by genomic screenings; (2) Full-length cDNA collection and setup of
systems for high-throughput in vitro and in vivo gene delivery; (3) Generation of a collection of
expression plasmids encoding small interfering RNAs, for loss of function analysis; (4) Adaptation
of existing biochemical and cell-based assays to a high-throughput configuration; (5) Proteomic
analysis of signal transduction and protein-protein interaction; (6) Bioinformatic networking.This
will greatly increase Europe competitiveness and validate several new molecular targets for
anticancer drug discovery.
Additional document:
int_30035.doc
European Light Microscopy in Functional Genomics/Proteomics
Acronym :
ELMiNet
Organisation:
Gothenburg University
Contact person details
Title:
Professor
Family Name:
Nilsson
Address:
Department of Medical Biochemistry
Goteborg University
Medicinaregatan 9A
413 90 Gothenburg
Country:
Telephone N°:
E-mail:
Gender:
First Name:
Sweden
+46-31-7733488
Fax N°:
nilsson@embl-heidelberg.de
M
Tommy
+46-31-416108
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
In ?Genomics and Biotechnology for Health?, the success of Functional Genomics/Proteomics
requires a coordinated implementation of Light Microscopy. Following a pan- European Initiative
launched in 2001, we have identified more than 60 partners in Academia and Industry interested in
driving Light Microscopy forward by taking an integrated approach in meeting the demands of
future European Research. We can now state that infrastructure as well as explicit intent is in place
to form a Network of Excellence termed European Light Microscopy Network (ELMiNet) for
effective dissimination of know-how through exchange of researchers and information. The spirit
of ELMiNet is inclusiveness and aims to ensure that state of the art techniques and equipment
become readily available and implemented for all European users thusensuring effective use of
present and future investments.
Additional document:
int_36537.doc
European Network for Integration of Genetic, Molecular, and Epidemiological research into
Cardio-Cerebro-Vascular-Renal Disorders
Acronym :
ENIGME-CCVRD
Organisation:
University of Leuven (K.U.Leuven)
Contact person details
Title:
Dr.
Gender:
Family Name:
Staessen
First Name:
Address:
Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium
Country:
Belgium
Telephone N°:
+32 16 34 7104
Fax N°:
E-mail:
jan.staessen@med.kuleuven.ac.be
M
Jan
+32 16 34 7106
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The last decade witnessed tremendous progress in high-throughput genomics and proteomics
as well as in cell and molecular biology. However, the pathophysiology of polygenic
age-related disorders remains insufficiently understood. To clarify the pathogenesis of
complex cardio-cerebro-vascular and renal disorders, the ENIGME-CCVRD network will integrate
genetic, molecular and epidemiological research. The consortium will take full advantage of
existing and new population and patient cohorts to determine the relationship between gene
function and health as opposed to disease, will develop genetic epidemiology tools,
implement validated procedures for genotyping, and improve the prevention and management
of important causes of mortality and morbidity. The network will achieve integration by
structuring collaborative projects across disciplines and Member States. It will spread
excellence through the network, by providing new strategies for prevention and treatment
of chronic age-related disorders, by enabling a more cost-effective expenditure of health care
resources and by collaboration with researchers in developing countries of Africa and Asia.
Additional document:
int_38491.pdf
European Network of Excellence on Molecular Recognition-based Separation Engineering
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
via Luigi Borsari, 46
I-44100 Ferrara
Italy
EuNEx MoRSE
Department of Chemistry, University of Ferrara
Prof
Dondi
Gender:
First Name:
M
Francesco
Country:
Telephone N°:
E-mail:
Italy
+39 0532 291154
f.dondi@unife.it
Fax N°:
+39 0532 240709
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.3.i Nanotechnologies and Nanosciences
1.1.3.ii Knowledge-based Multifunctional Materials
1.1.5 Food Quality and Safety
1.1.6.3 Global Change and ecosystems
Abstract:
The extended demand of separation methods and tools deriving from several thematic Areas, the
innovative approach of Separation Science moving towards the use of Molecular
Recognition-based mechanisms as the base of separation and the increasing employement of
Nanotechnologies in designing separation tools, stimulates the proposal of a Network of
Excellence on "Molecular Recognition-based Separation Engineering". The conceptual structure of
the Network results from coordination and integration of different scientific and technological
fields such as Separation Science, Synthetic Chemistry, Physical Chemistry, Nanotechnologies,
Computational Sciences. The horizontal character of this Network allows optimum interaction with
other thematic Networks and Programs underliyng the strategic character of EuNEx MoRSE for
the VI Framework Program.
Additional document:
int_30448.pdf
European Network of Insect Genomics for Medicine and Agriculture
Acronym :
ENIGMA
Organisation:
INRA
Contact person details
Title:
Dr
Family Name:
Feyereisen
Address:
INRA centre de recherche d'Antibes
1382 route de Biot
06560 valbonne
France
Country:
France
Telephone N°:
33 493 12 38 02
E-mail:
rfeyer@antibes.inra.fr
Gender:
First Name:
M
Rene
Fax N°:
33 493 12 25 28
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
This Network will unite the critical mass of insect scientists in the European Research Area
to tackle emerging global problems such as malaria and insect- related pressures on world
food supply and quality. ENIGMA will use core genomic and post-genomic technologies
with central and ambitious goals: to abolish the fractionation of insect research between
model species, vectors of disease and agricultural pests by exploiting comparative
genomics; to enable breakthroughs in research on the physiological mechanisms which
determine the success of insects as vectors and pests. ENIGMA comprises the top
institutions with well over 60 research groups representing 16 European countries.
ENIGMA will provide a vehicle for training, risk assessment and knowledge transfer in
vector control and agricultural pest control to developing countries.
Additional document:
int_36876.pdf
European network on comparative genomics in Musa.
Acronym :
ENCOGEM
Organisation:
Katholieke Universiteit Leuven, KULeuven
Contact person details
Title:
Doctor
Gender:
F
Family Name:
Aert
First Name:
Rita
Address:
Laboratory Of Gene Technology (LoGT)
Kasteelpark Arenberg 21
B-3001 Leuven, Belgium
Country:
Telephone N°:
E-mail:
Belgium
3216329671
Fax N°:
rita.aert@agr.kuleuven.ac.be
3216321965
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
Among plants, the most important genome models so far studied have been rice and Arabidopsis.
However, in order to understand the universal features of genome organization and develop
exploitable tools applicable to all species, it is clear that that a further model is required. More
basic genomic information is needed to meet the challenges of exploring the interactions of genes
with each other and with their environment. European scientists have demonstrated excellence in
the efficient leveraging of exploitable knowledge from public genome information. In this
proposed network, we will develop the genome of Musa spp. (banana) as a platform for
comparative genomics. By bringing together European expertise, and developing the next
generation of talented people, this network will put in place underpinning models, techniques for
exploiting, and expertise for delivering value from understanding the functioning of all higher
genomes, animal and plant, in differentiating, developing and disease states using high-efficiency,
incremental strategies.
Additional document:
int_30037.doc
European Program on the Metazoan Tree of Life
Acronym :
EUROMETATREE
Organisation:
UNIVERSITAT DE BARCELONA
Contact person details
Title:
Prof
Gender:
Family Name:
BAGUNA
First Name:
Address:
Departament de Genetica, Facultat de Biologia,
Universitat de Barcelona, Diagonal 645,
08028 Barcelona
Country:
Spain
Telephone N°:
34-93-4021497
Fax N°:
E-mail:
bagunya@porthos.bio.ub.es
M
JAUME
34-93-4110969
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6.3 Global Change and ecosystems
Abstract:
We aim to map the evolution of Earth’s species of Metazoa and show how they split off from one
another over time. We will use a multigenic approach identifying and sequencing new nuclear
genes, the mitochondrial genome, and whenever available the Hox gene cluster using BAC
libraries. Comparative expression analyses and functional assays will also be carried out in extant
selected clades involved in key evolutionary steps. The new Tree of the Metazoa will: 1) provide
all biologists and taxonomists with a sounder Systematics of the Metazoa; 2) help genome
researchers to make more meanigful comparisons of genes and proteins; 3) afford biomedical
researchers and epidemiologists better methods to understand disease spreading; 4) help
conservationists to better assess biodiversity and extinction; and 5) provide parasitologists with a
phylogenetic framework to better understand parasite biology.
Additional document:
int_37364.doc
European Protein Distribution Database and Visualisation Archive
Acronym :
PROTVIZ
Organisation:
University of Glasgow
Contact person details
Title:
Dr
Gender:
Family Name:
Daly
First Name:
Address:
Wolfson Building (room 448)
Faculty of Biomedical & Life Sciences
University of Glasgow
Glasgow G12 8QQ
Country:
United Kingdom
Telephone N°:
+44 141 330 3920
Fax N°:
E-mail:
c.daly@bio.gla.ac.uk
M
Craig
+44 141 330 2923
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.2 Information Society technologies
1.1.2.ii Communication, computing and software technologies
Abstract:
Genomics and proteomics have enabled biologists to search and compare gene and protein
sequences via a varierty of bioinformatics tools. However, a gap exists between our knowledge of
protein structure and our understanding of protein function and spatial distribution within cells.
The European PROTVIZ project aims to fill this gap by creating a public database of receptor
protein distribution. The database will be indexed in a way that will enable information scientists to
build relational links between the PROTVIZ database and the existing sequence databases. This
will be the first step towards integrating sequence and functional databases. The project will aim to
set global standards for the archiving of subsequently similar data. In addition, the archive will hold
multi-dimensional data sets which will be used for visualisation of protein interactions and will
enable others to view and model the collected data. The project draws on the expertise of European
enable others to view and model the collected data. The project draws on the expertise of European
science and gives a significant lead in the emerging area of genomics and information sciences.
Additional document:
int_38000.doc
European Resource of Ligand Binding Molecules against the Human Proteome
Acronym :
EuroBinders
Organisation:
The Babraham Institute
Contact person details
Title:
Dr
Gender:
Family Name:
Taussig
First Name:
Address:
Technology Research Group,
The Babraham Institute,
Babraham, Cambridge CB2 4AT,
UK
Country:
United Kingdom
Telephone N°:
441223496557
Fax N°:
E-mail:
mike.taussig@bbsrc.ac.uk
M
Michael
441223496045
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Characterisation of the human proteome requires a comprehensive collection of specific ligand
binding molecules (antibodies, scaffolds, aptamers) corresponding to each protein in its native and
modifed forms. Since the human proteome may encompass upwards of 500,000 molecular species,
obtaining such a collection is a huge task which must be coordinated in order to be effective. The
objective of this Network is to create a European resource of ligand binding molecules covering
the entire human proteome, which will be made freely available to biomedical researchers for
application in functional genomics projects. A European resource of proteome binding reagents
will lead to enormous benefits for basic and applied research, healthcare, diagnostics, drug
discovery and therapeutics.
Additional document:
int_29908.doc
Evolution of endocytic machinery
Acronym :
Endocytic-evolution
Laboratory of Cell Membrane Physiology,Department of Cell
Organisation:
Biology,Nencki Institute of Experimental Biology
Contact person details
Title:
Dr
Gender:
F
Family Name:
Wyroba
First Name:
Elzbieta
Address:
3 Pasteur Str,. 02-093 Warsaw, POLAND
Country:
Telephone N°:
E-mail:
Poland
(48-22)659-85-71
wyroba@nencki.gov.pl
Fax N°:
(48-22)822-53-42
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Abstract:
Endocytosis is a fundamental process in living cell enabling delivery of essential nutrients and
communication with surrounding environment. Disturbances in this pathway may lead to health
malfunctions. We identified gene fragments encoding the following components of endocytic
machinery participating in endosome formation, sorting and maturation of proprotein precursors,
respectively: dynamin 2, Rab7 and furin in unicellular eukaryote Paramecium. All are expressed
and show a very high homology to human counterparts thus pointing out to this cell as a model
system - similarly to our previous studies on uptake of photosensitizers used in photodynamic
therapy of tumors. Growing evidence suggests that endocytosis is also involved in signal
termination, propagation and activation and therefore deciphering molecular mechanism
underlying this process is of major biological interest.
Additional
int_29446.doc
document:
Exploiting membrane protein synthesis in health and disease
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
School of Biological Sciences
Mem-prot-ex
University of Manchester
Professor
High
Gender:
First Name:
M
Stephen
University of Manchester
2.205 Stopford Building
Oxford Road
Manchester
M13 9PT
Country:
Telephone N°:
E-mail:
United Kingdom
0044 161 275 5070
Fax N°:
shigh@fs1.scg.man.ac.uk
0044 161 275 5082
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Despite compelling medical and economic drivers, pitifully few high resolution structures of
Despite compelling medical and economic drivers, pitifully few high resolution structures of
complex membrane proteins are currently being produced. The goal of this integrated project is to
tackle this problem at source, and we will dramatically enhance the production of recombinant
membrane proteins and exploit this material for structural and functional studies. We will use a
defined set of commercially relevant membrane proteins to challenge a series of rationally
optimised expression systems. Our vision is to mobilise the wealth of available European expertise
in distinct facets of membrane protein biology. We will harness this scientific and technical
excellence to create a portfolio of complementary expression systems that will provide real
solutions to a very real problem and directly benefit both the academic and commercial consumer
communities.
Additional document:
int_38162.doc
Function of signal-dependent transcription factors in oncogenesis and development
Acronym :
ONCOTAF
Organisation:
University of Innsbruck
Contact person details
Title:
Dr.
Family Name:
Hartl
Address:
Institute of Biochemistry
Peter-Mayr-Straße 1a
A-6020 Innsbruck
Country:
Austria
Telephone N°:
0043-512-507-5271
E-mail:
markus.hartl@uibk.ac.at
Gender:
First Name:
M
Markus
Fax N°:
0043-512-507-2894
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.b Combating cancer
Abstract:
Regulation of prototypic oncogenic transcription factors by upstream signal transduction cascades
and subsequent transcriptome and genome alterations will be analyzed in distinct avian and
mammalian cell systems suitable to investigate oncogenic and developmental processes. The
comprehensive identification and functional characterization of critical transcriptional target genes
will constitute a major focus in this INTEGRATED PROJECT. The elucidation of common
principles underlying operative pathways in oncogenesis and development will result in a deeper
understanding of these biological processes in molecular terms. Furthermore, selection of specific
components of cell transformation pathways as potential drug targets should contribute to the
development of novel therapeutic principles to interfere with tumorigenesis.
Additional document: int_37062.doc
Functional genomics for new connections in bacterial communication networks: from pathogenicity
to biodiversity
Acronym :
Bact.Com
Organisation:
CNRS
Contact person details
Title:
Professor
Gender:
Family Name:
Zhang
First Name:
Address:
Laboratoire de Chimie Bactérienne, IBSM
CNRS
31 chemin Joseph Aiguier
13402 Marseille cedex 20
Country:
France
Telephone N°:
0033-4-91164096
Fax N°:
E-mail:
cczhang@ibsm.cnrs-mrs.fr
M
Cheng-Cai
0033-4-91718914
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Protein phosphorylation is the main mechanism by which intracellular events are controlled by
external physiological stimuli. Bacterial genomic data revealed the presence of nume-rous genes
encoding putative protein kinases and phosphatases. The understanding of the associated
mechanisms of signal transduction will greatly enhance our capacity to control the proliferation
and pathogenicity of bacteria, enabling us to develop new therapeutic stra-tegies for pathogens or
find new applications for biotechnology. The aim of this proposal is to strengthen the collaboration
among European laboratories and to establish the leader role of Europe in the studies of bacterial
signaling. Functional genomic and multidisciplinary approaches will be used to study the basic
mechanisms of bacterial signaling and to define new targets for the development of future drugs
against human pathogens.
Additional document:
int_35981.doc
Functional genomics in the maize grain, a model for cereal seed development
Acronym :
EUkernel
Organisation:
University of Alcala
Contact person details
Title:
Dr.
Gender:
Family Name:
Hueros
First Name:
Address:
Dpto. Bologia Celular y Genetica,Univ. Alcala
Alcala de Henares, Madrid, Spain
Country:
Spain
Telephone N°:
+34918854758
Fax N°:
E-mail:
gregorio.hueros@uah.es
M
Gregorio
+34918854799
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6 Sustainable development, global change and ecosystems
Abstract:
Cereals are the most important crops worldwide and their grain contributes more than 60% to
human nutrition. Grain yield and nutritional balance are thus of primordial importance for human
health. In addition to their nutritional value for humans and livestock, cereals are the most
important renewable source of raw materials for industrial processes.
Despite this pivotal socio-economic position of cereals, the information on the molecular basis of
cereal grain development is scarce. Knowledge gathered in the model plant species Arabidopsis is
of little use due to fundamental differences in grain development. Attempts to improve cereal
performance by knowledge-driven approaches are thus seriously hampered. Maize grain research
is by far the most advanced among the cereals and the well established European maize scientific
community has largely contributed with molecular, cytological and genetic approaches. We
propose here to tackle this problem in a holistic approach, including functional genomics,
proteomics and metabolomics.
Additional document:
Not available
Functional genomics of antibiotic-producing Streptomyces
Acronym :
STREPGEN
Organisation:
UNIVERSITY OF WALES SWANSEA
Contact person details
Title:
Dr
Gender:
Family Name:
DYSON
First Name:
Address:
SCHOOL OF BIOLOGICAL SCIENCES
UNIVERSITY OF WALES SWANSEA
SINGLETON PARK
SWANSEA SA2 8PP UK
Country:
Telephone N°:
E-mail:
United Kingdom
441792295667
Fax N°:
p.j.dyson@swansea.ac.uk
M
PAUL
441792295447
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
As a consequence of the landmark completion of the genome sequence of Streptomyces coelicolor,
and the provision of key functional genomic resources, we are now in a unique position to
investigate gene function, antibiotic production, ecology, physiology and development in this
model organism closely related to Mycobacterium tuberculosis.
Additional document:
int_29404.doc
Functional Genomics of Plant Secondary Metabolism: a resource for health and medicine
Acronym :
Organisation:
GENSEM
.Department of Natural Products and Biotechnology,Mediterranean
Agronomic Institute of Chania
Contact person details
Title:
Dr
Family Name:
Johnson
Address:
Alsyllion Agrokepion
73100 Chania
Greece
Country:
Telephone N°:
E-mail:
Greece
(30-821) 081151
cjohnson@maich.gr
Gender:
First Name:
M
Christopher
Fax N°:
(30-821) 81154
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
This project will involve a multidisciplinary approach to elucidate the mechanism of plant
secondary compound metabolism by identifying the genes involved and deciphering their
biological functions. High-throughput methods of analysis of genes, proteins and metabolites
associated with the main groups of secondary compounds will be exploited and, where necessary,
developed. The work will encompass the application of structural studies and investigation of
protein interactions and will include the development of new bioinformatics tools for managing
and interpreting the data generated. Understanding the pathways of synthesis of these compounds
and their regulatory networks will enable their full exploitation in health and medicine.
Additional document: int_29092.doc
Functional genomics of the mammary gland in health and disease
Acronym :
Fugema
Organisation:
Institut National de la Recherche Agronomique
Contact person details
Title:
Dr
Gender:
F
Family Name:
Ollivier-Bousquet
First Name:
Michèle
Address:
Inra
Unité de Biologie cellulaire et moléculaire
78352 Jouy-en-Josas cedex
Country:
France
Telephone N°:
330134652549
Fax N°:
330134652241
E-mail:
ollivier@jouy.inra.fr
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Elucidation of mechanisms that control mammary development, function and neoplasia is
fundamental to advancement of breast cancer therapy, to promotion of breastfeeding and neonatal
health, and to sustainable agriculture. The tools of biotechnology, including genomics and
proteomics, allow new approaches to these goals. Our European research consortium, founded
through COST Action, will use these tools to build a globally-competitive programme of
interdisciplinary research. The Network of Excellence will co-ordinate research on functional
genomics of the mammary gland.The objectives are to describe the gene and protein signals that
control normal and tumour growth in various species; to apply results in new therapeutic strategies;
to enable biological interpretation of epidemiologic data and sustainable agriculture; to promote
training and knowledge transfer.
Additional document:
Not available
Functional genomics, proteomics and cell signaling in the immune system
Acronym :
ImmuGen
Organisation:
University of Cadiz
Contact person details
Title:
Prof Asociado
Gender:
M
Family Name:
Garcia-Cozar
First Name:
Francisco J.
Address:
Unidad de Investigación Hospital Universitario de Puerto Real/Universidad de Cadiz. Carretera
Nacional IV Km 665. Puerto Real 11510. Cadiz. Spain
Country:
Spain
Telephone N°:
34670399971
Fax N°:
34956830477
E-mail:
curro.garcia@uca.es (http://www.espagen.com)
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
1.1.3.i Nanotechnologies and Nanosciences
Abstract:
Autoimmune diseases, hypersensitivity, allograft rejection and failure of immune therapy are
common clinical situations that stem from immune system malfunction. Since a great number of
cellular and molecular processes are involved, joint coordinated efforts are needed to deepen our
understanding of general issues such as immune cell transformation, tolerance and inflammation.
Our consortium brings together basic as well as clinical expertise and infrastructure, allowing use
of high throughput techniques such as DNA microarray and proteomics in combination with
functional studies of relevant genes in animal models and clinical situations. Development of
nanobiosensors, analysis of cell-cell, protein-protein and protein-DNA interactions, gene silencing,
intracellular signaling, transcriptional regulation and cell cycle control studies are among our
capabilities.
Additional document:
int_29508.doc
Functional Proteomics: Towards defining the interaction proteome
Acronym :
INTERACTION PROTEOME
Max-Planck- Gesellschaft zur Förderung der Wissenschaften, represented by :
Organisation:
Max-Planck-Institut für Biochemie, Martinsried, Germany
Contact person details
Title:
Prof. Dr.
Gender:
M
Family Name:
Hartl
First Name:
F.-Ulrich
Address:
Max-Planck-Institut für Biochemie
Am Klopferspitz 18A
D-82152 Martinsried, Germany
Country:
Germany
Telephone N°:
498985782233
Fax N°:
498985782211
E-mail:
uhartl@biochem.mpg.de
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
The aim of INTERACTION PROTEOME is to establish Europe as the International scientific
leader in functional proteomics, i.e. in the analysis of protein-protein interactions. Major objectives
of the proposed Integrated Project include the establishment of a 2D-gel-free, automated
high-throughput proteome technology platform with broad applicability by 2006 along with a
platform to integrate toponomic and proteomic analyses of protein complexes. The latter will
integrate light and electron microscopy for the resolution of protein networks. Protein-protein
interaction data obtained in the project will be collected in a public novel protein interactions
database. Software for in silico modeling of protein interactions will be developed by 2007. These
tools will form the basis for an efficient analysis and systems modeling of fundamental biological
processes in health and disease.
Additional
Not available
document:
Gene expression profiling in cancer research: pathogenetic and therapeutic clues
Acronym :
Organisation:
CANCERARRAY
Centre of Oncology - Maria Sklodowska-Curie Memorial Institute,
Gliwice, Poland
Contact person details
Title:
Prof
Gender:
Family Name:
Jarzab
First Name:
Address:
Centre of Oncology - Maria Sklodowska-Curie Memorial Institute,
Dept. of Nuclear Medicine and Endocrine Oncology,
Wybrzeze Armii Krajowej 15, 44-100 Gliwice, Poland
Country:
Telephone N°:
E-mail:
Poland
48322789301
bjarzab@io.gliwice.pl
Fax N°:
F
Barbara
48322313512
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.b Combating cancer
Abstract:
DNA microarray technology promises a breakthrough in studies on pathogenesis and therapy of
cancer, since it enables assessing changes in the expression level of numerous genes, allowing not
only a better understanding of neoplastic transformation and progression, but also a more acccurate
classification of cancer subtypes, prediction of the optimal therapy and prognosis of outcome.
Wealth of data gained by microarrays studies require a much closer interdisciplinary cooperation
that it has been predicted until now. The aim of the project is to perform a number of specific
tumor gene expression profiling studies directed to the area of interest of participating groups,
among them hormone-dependent tumors occuring in women (thyroid and breast ca) and tumors
with the poorest prognosis, in which no major improvements have been achieved until now, such
as lung cancers, melanomas and gliomas, as well as hematopoietic malignancies, to analyse them
by optimised mathematical modelling and next to make them open for further cross-comparisons in
order to improve both our understanding of tumor biology and answering clinical questions.
Additional document: int_29470.doc
Gene-environmental interactions in inflammatory periodontitis
Acronym :
GENVIP
Organisation:
University of Manchester
Contact person details
Title:
Dr
Gender:
Family Name:
James
First Name:
Address:
University Dental Hospital of Manchester,
Higher Cambridge Street, Manchester, United Kingdom, M15 6FH
F
Jacqueline
Country:
Telephone N°:
E-mail:
-4401612756797
United Kingdom
44(0)1612756712
jackie.james@man.ac.uk
Fax N°:
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
Abstract:
Aim: To explore gene-environment interactions in inflammatory periodontitis. Background:
Periodontitis variably affects up to 90% of individuals. Severe disease results in poor life quality.
The rate of disease progression indicates a multifactorial inher
Additional document:
int_30187.doc
Genetic and molecular ecology of Plant Adaptation to a Changing Environment
Acronym :
PACE
Organisation:
Centre National de la Recherche Scientifique UPR2357
Contact person details
Title:
Dr.
Gender:
F
Family Name:
Werck-Reichhart
First Name:
Danièle
Address:
Institute of Plant Molecular Biology
Department Plant Stress Response
28, rue Goethe
F-67 000 Strasbourg, France
Country:
Telephone N°:
E-mail:
France
33(0) 3 90 24 18 54
Fax N°:
daniele.werck@ibmp-ulp.u-strasbg.fr
33 (0) 3 90 24 18 84
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
Plants are sessile organisms that to survive have developed unique abilities to adapt to climatic,
chemical and biotic changes in their natural environment. This has resulted in an extreme
variability and complexity in their chemical composition, driven by evolution of large gene
families, and intricate signalling cascades. Plant gene super families in turn provide a platform for
fast adaptation, and determine plant tolerance to UV light, environmental chemicals, resistance to
pathogens and herbivores. Only a small proportion of the plant genes that govern plant adaptive
response is so far identified. Much less is known about their real potential for plant protection, fast
adaptation to environmental changes, phytoremediation of contaminated sites, or the impact of
altered metabolism and defence on food constituents and nutritional quality. Such knowledge may
become critical with accelerated and uncontrolled perturbation of the local and global
environments. We propose to use the tools of genomics, proteomics and metabolomics to identify
relevant genes, transcription factors, enzymes and metabolites important for plant stress signalling
and response to environmental challenges.
Additional document:
int_30929.doc
Genetic Markers for Osteoporosis
Acronym :
GENOMOS
Organisation:
University of Malta
Contact person details
Title:
Professor
Family Name:
Xuereb Anastasi
Address:
Department of Pathology,
University of Malta Medical School,
Guardamangia MSD06,
Malta
Country:
Telephone N°:
E-mail:
Gender:
First Name:
Malta
35625951882
Fax N°:
angela.a.xuereb@um.edu.mt
F
Angela
35621235638
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Osteoporosis is a complex disease with a strong genetic component. Early identification of subjects
at risk could help prevent this disease. Gene polymorphisms are the most probable risk factors. In
Malta we are currently conducting studies on the genotyping of candidate genes involved in
osteoporosis, for example, the vitamin D receptor gene and the oestrogen receptor gene in
postmenopausal women, and measuring bone density and biochemical bone markers. We would
like to collaborate with other European partners conducting similar studies in the GENOMOS
project. The inclusion of a sample of Maltese subjects could contribute to the European-wide
collection of DNA samples for evaluating risk genes for osteoporosis. The expansion of the project
to include more diverse European populations would ensure that the study is a very significant and
robust one.
Additional document:
int_30030.doc
Genetic mechanisms in development and (patho)physiology of the kidney
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Robert-Roessle-Strasse 10
D-13125 Berlin
Germany
Country:
Telephone N°:
E-mail:
EUREGENE
Max-Delbrueck-Center for Molecular Medicine
Prof.
Willnow
Gender:
First Name:
Germany
493094062569
Fax N°:
willnow@mdc-berlin.de
M
Thomas
493094063382
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Diseases of the kidney represent a major cause of morbidity and mortality in Europe. This disease
burden and its challenge for our society is the focus of the present proposal. We will develop and
implement an interdisciplinary research program that integrates European excellence in research
relevant to renal development and (patho)physiology. Our goal is to discover genes responsible for
renal development and disease, their proteins, and their actions. To meet this goal, we have
established a consortium of basic scientists, clinicians and SME partners that will apply efforts
from molecular biology and cell biology, to studies in animal models and human populations.
Ultimately, our identification of disease genes will lead to a better understanding of disease
processes, to improved diagnosis and new concepts in therapy.
Additional document:
int_30456.pdf
Genetic variants of hormones, their activities and milk performance of cattle
Acronym :
Functional genetics
Organisation:
The University of South Bohemia, Czech Republic
Contact person details
Title:
Doc. Dipl. Ing. Cand. Sci.
Gender:
M
Family Name:
Citek
First Name:
Jindrich
Address:
The University of South Bohemia - Agricultural Faculty
Department of Genetics, Animal Breeding and Nutrition
Studentska 13
370 05 Ceské Budejovice
Czech Republic
Country:
Czech Republic
Telephone N°:
420387772591
Fax N°:
420387772593
E-mail:
citek@zf.jcu.cz
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
Abstract:
Genetic variants of hormones, their activities and milk performance of cattle
Ambition:To analyse hormones genetic variants, their activities, and performance in cattle.
Objectives: 1/ To establish set of hormones with detected polymorphisms, potentially able
to regulate productive traits: A/ growth hormone polymorphisms. Southern blot analysis
(e.g. TaqI revealed 4 DNA fragments; HindIII - two RFLPs). Leu/Val substitution of GH amino
acid 127 by the PCR/RFLP. SSCP within GHG etc. B/ Polymorphism of GHR gene. The new
polymorphisms will be looked for. C/ Polymorphisms of DGAT1 gene, leptin and pituitary
transcription factors. The set of analysed loci will be adapted to the new knowledge.
2/ To analyse the activity of different polymorphic hormone variants in vitro. 3/ To look
for association between polymorphic hormones and productive traits.
Integration
We want to join the 6FP in order to do the research more extent, to combine the capacity
of more labs and their methodical abilities. Until we have co-operated with FBN Dummerstorf,
Germany, e.g. (see Panicke, Citek et al., 2001, Czech J Anim Sci, 46, 202-208.).
Additional document:
int_28084.doc
Genome and Environment, Implication of Genetic and Epigenetic Factors on the Development and
Ageing of Living Organisms
Acronym :
GE-DALO
Organisation:
Centre National de la Recherche Scientifique (CNRS)
Contact person details
Title:
DR
Gender:
M
Family Name:
JAMON
First Name:
Marc
Address:
INPC, Equipe " Psychophysiologie du Développement Moteur ",
31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, FRANCE
Country:
France
Telephone N°:
(33) 4 91 16 40 86
Fax N°:
(33) 4 91 77 50 84
E-mail:
jamon@dpm.cnrs-mrs.fr
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
Abstract:
Genomic expression is affected by epigenetic factors. The mechanisms of this interaction is a
central question for functional genomics. In order to extract the "invariants" leading to basic
rules for the role of environment on the genomic expression, we propose to confront various
biological systems (from cell to plants and animals) at different stages of the organisms' life
(development, ageing,…) to modulations of a common environmental factor. We propose to
begin with a universal force, acting evenly on any organism, the gravity. To enable this
multidisciplinary approach we need to gather researchers with high expertise in genetics,
molecular biology, physiology, and behaviour in a Network of Excellence. Advances in Biology,
new development of facilities allowing studies under altered gravity (ISS, centrifuges…)
and grouping of numerous teams make it now possible.
Additional document:
int_36680.pdf
Genome-Wide Scale Search for Transmembrane Proteins and Functional Residues
Acronym :
TMP
Organisation:
Tel Aviv University
Contact person details
Title:
Dr.
Gender:
Family Name:
Ben-Tal
First Name:
Address:
Dept of Biochemistry, Tel Aviv University, Ramat Aviv 69978, Israel
Country:
Israel
Telephone N°:
(972-3) 640-6709
Fax N°:
E-mail:
bental@ashtoret.tau.ac.il
M
Nir
(972-3) 640-6834
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The proposed Network of Excellence has two related main goals. First, to carry out wide genome
scale searches for transmembrane (TM) proteins. We will use existing bioinformatics tools (some
of which were developed in our labs) and develop new ones if necessary. The search for TM
proteins will include proteins from the cytoplasmic, inner organelles and bacterial outer
membranes. Membrane proteins are the most common drug targets and the project is very likely to
produce more of them. The second goal is to look for functionally important residues (e.g., these
involved in catalysis and protein-protein interactions) both in TM and globular proteins. We will
use evolutionary information to look for such residues. The outcome of the project is likely to help
in manipulating the interactions and may therefore be useful for the pharmaceutical industry.
Additional document:
int_29703.doc
Genomic determination of development and function of adipose tissue(as precursor of type 2
diabetes and cardiovascular disease)
Acronym :
GENOFAT
Organisation:
Copenhagen University Hospital, Institute of Preventive Medicine
Contact person details
Title:
Professor, Dr Med Sci
Gender:
M
Family Name:
Sørensen
First Name:
Thorkild I.A.
Address:
Institute of Preventive Medicine, Kommunehospitalet, Entrance 23A, Øster Farimagsgade 5, DK
1399 Copenhagen K, Denmark
Country:
Telephone N°:
E-mail:
Denmark
4533383860
tias@ipm.hosp.dk
Fax N°:
4533324240
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.5 Food Quality and Safety
Abstract:
There is urgent need for development of improved strategies for combating health and disability
problems of obesity, type 2 diabetes and cardiovascular disease. Despite a recent decline in
incidence of and mortality from cardiovascular disease, a future d
Additional document:
int_30241.doc
Genomic Signal Representation and Analysis
Acronym :
GenSig
Organisation:
<> University of Bucharest (UPB)
Contact person details
Title:
Prof
Gender:
Family Name:
CRISTEA
First Name:
Address:
Biomedical Engineering Center
Spl. Independentei 313, sect.6, 77206 Bucharest, Romania
Country:
Romania
Telephone N°:
40214114437
Fax N°:
E-mail:
pcristea@dsp.pub.ro
M
Paul Dan
40214104414
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The proposed NoE aims to the systematic analysis of genomic data for prokaryote and
eukaryote organisms, including home sapiens, to extract valuable knowledge that has
relevance both for the better understanding of the genomic information and for potential
applications in medicine and biology. The proposed original methodology is the conversion
of DNA sequences into digital genomic signals. Such an approach allows using powerful
digital signal processing methods and algorithms for the processing of genomic sequences
and largely increases the efficiency of their analysis. The consortium brings together a
considerable expertise in Biology, Genomics, ICT, Data & Signal Processing, HPC and other
topics relevant for Genomic Signal Representation and Analysis. This provides an almost
ideal context to carry out the multidisciplinary activities implied by the NoE topics.
Additional document:
int_29939.doc
Genomics and bioinformatics usage to reduce inputs of cereals production
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
ul. Strzeszynska 34,
60-479 Poznan, Poland
Country:
Telephone N°:
E-mail:
GENBIP
INSTITUTE OF PLANT GENETICS, Polish Academy of Sciences
Prof.
Chelkowski
Gender:
First Name:
M
Jerzy
Poland
(+48 61) 822 11 12
office@igr.poznan.pl
Fax N°:
(+48 61) 8233 671
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Low resistance of cultivated cereals causes increase of production costs. New resistant cultivars
have to be derived for sustainable farming system, for reduction of extensive usage of
agrochemicals and for improvement of final product quality (prevention of mycotoxins in grains).
Data present in various resources on resistance genes identified in various cultivars and
germplasms will be organised in the uniform bioinformatic system. DNA sequences of gene clones
and clone libraries, as well as STS, SCAR, SSR, RAPD and AFLP markers for resistance genes
and important agronomic characters as yield-related traits, malting quality, bread-making quality
will be collected and incorporated into the same data management system. Co-operation of
institutes and breeding companies with needs of sustainable agriculture of Central and Eastern
Europe will be in focus and will be integrated.
Additional document:
int_29156.doc
Genomics and Proteomics in Plant Pathology and Plant Protection
Acronym :
Organisation:
AgroPathOmics
Agro-Genomics/Agro-Proteomics Network North Rhine-Westphalia,
Germany
Contact person details
Title:
Prof. Dr.
Family Name:
Moerschbacher
Address:
Westfälische Wilhelms-Universität Münster
Institut für Biochemie und Biotechnologie der Pflanzen
Hindenburgplatz 55
48143 Münster
Country:
Telephone N°:
E-mail:
Germany
+ 49 251 83247 94/91
moersch@uni-muenster.de
Gender:
First Name:
M
Bruno
Fax N°:
+ 49 251 8328371
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
The AgroPathOmics Integrated Project will combine the expertise and resources of top university
and non-university research groups and key players from the agro-industries located in the three
leading European centres of molecular plant pathology - North Rhine-Westphalia (D), Norwich
(UK), and Wageningen (NL), supported by selected renowned experts from other EU countries for co-ordinated post-genomic, proteomic, and bio-informatic approaches in basic and applied
phytopathology. The project will include both model and crop plants with their pathogens, yielding
genetic markers for resistance breeding and molecular targets for novel plant protectants. A small
number of European Graduate Schools will guarantee efficient multilateral communication
between all partners. The project will allow EU research and industry to remain at the forefront of
plant biotechnology in the interest of sustainable production of healthy food in a healthy
environment.
Additional document:
int_37961.pdf
Genomique fonctionnelle et comparative utilisant Paramecium tetraurelia
Acronym :
Organisation:
ParameciumGenome
CENTRE DE GENETIQUE MOLEULAIRECENTRE NATIONAL DE LA
RECHERCHE SCIENTIFIQUE
Contact person details
Title:
Dr.
Gender:
M
Family Name:
COHEN
First Name:
Jean
Address:
Gentre de Génétique Moléculaire, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette cedex
France
Country:
Telephone N°:
E-mail:
France
33169824373
cohen@cgm.cnrs-gif.fr
Fax N°:
33169823150
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Les recherches sur la paramécie (Paramecium tetraurelia) ont atteint un degré de maturité tel que
nous envisageons le séquençage de son génome en vue d'une génomique fonctionnelle et
comparative. La paramécie, comme tous les ciliés, présente deux génomes au sein d'une même
cellule. Le génome somatique dérive du génome germinal (120 Mb) par réarrangements de
séquences apparentés à ceux rencontrés dans la lignée hématopoÏétique et dans certains cancers,
par élimination de séquences, et par amplification massive. L'existence d'une génétique
performante et de procédés d'extinction génique aisés permet d'envisager une étude fonctionnelle à
grande échelle. Notre projet est (1) de promouvoir le séquençage et l'annotation comparative des
deux génomes avec mise au point de programmes de recherche de gènes et (2) d'entreprendre une
analyse fonctionnelle par extinction génique systématique et par étude du transcriptome. Le
consortium de laboratoires européens, GDRE " Paramecium Genomics "soutenu par le CNRS,
pourra être au cœur d’une étude d'une telle envergure grâce à la complémentarité des compétences
en son sein et avec l’aide des autres laboratoires travaillant sur les ciliés.
Additional
int_28872.txt
document:
GLUTAMINE AS A SIGNAL
Acronym :
SIGNALQ
Organisation:
UNIVERSIDAD DE MÁLAGA
Contact person details
Title:
Dr
Gender:
M
Family Name:
JAVIER
First Name:
MARQUEZ
Address:
Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias,
Universidad de Málaga, 29071 Málaga, Spain
Country:
Spain
Telephone N°:
34-952-132024
Fax N°:
34-952-132000
E-mail:
marquez@uma.es
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
Many cellular processes seem to be regulated by glutamine. Apart from its relevant role in cellular
metabolism, emerging evidence is now linking glutamine with signalling cascades related to cell
growth and proliferation. Furthermore, glutamine might also play an important role in protecting
cells from apoptosis and may function as a transcription signal. These facts prompted us to
consider glutamine as a signal and the target of this action. The research will focus on elucidation
of the mechanisms underlying those fundamental processes in which glutamine plays a key role,
including cell growth, proliferation and apoptosis, glutamine-induced cell swelling and activation
of osmosignaling pathways, and the regulation of the glutamine/glutamate cycle in brain. The
methodologies of functional genomics and proteomics will be employed as essential tools to
ascertain these issues.
Additional document:
int_30003.doc
IMGT-European Excellence Network for Immunogenetics and Immunoinformatics
Acronym :
IMGT-EENII
Organisation:
Centre National de la Recherche Scientifique (CNRS)
Contact person details
Title:
Professor
Gender:
F
Family Name:
LEFRANC
First Name:
Marie-Paule
Address:
IMGT, the international ImMunoGeneTics database, http://imgt.cines.fr
Institut de Génétique Humaine, IGH, UPR CNRS 1142
141 rue de la Cardonille, 34396 Montpellier cedex 5
France
Country:
Telephone N°:
E-mail:
France
(33-4)99619965
lefranc@ligm.igh.cnrs.fr
Fax N°:
(33-4)99619901
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Europe has taken a lead in the development of IMGT, an high-quality integrated ImMunoGeneTics
information system, unique in the world, specialized in the multigene families of the specific
immune response in human and other vertebrates: Immunoglobulins, T
Additional document:
int_30302.doc
Innovative Analysis of Reproductive Health: Male and Female Meiosis
Acronym :
MEIOSIS
Organisation:
Erasmus University Rotterdam, Erasmus MC
Contact person details
Title:
Prof. Dr.
Gender:
M
Family Name:
Grootegoed
First Name:
J. Anton
Address:
Erasmus University Rotterdam
Erasmus MC
Department of Reproduction and Development
P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
Country:
Netherlands
Telephone N°:
+31-10-4087345
Fax N°:
+31-10-4089461
E-mail:
grootegoed@endov.fgg.eur.nl
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
In todays Europe, social changes and a longer life expectancy are associated with increasing
parental age at birth of the first child. As a result, a growing proportion of European couples
experience fertility problems and many couples have to resort to in vitro fertilization and other
forms of assisted conception. This development raises important medical, financial and bioethical
issues in connection with the possible transmission of mutations or aneuploidy to the children of
these patients. Molecular and genetic analysis of gametogenesis, including meiosis and epigenetic
reprogramming, have increased our knowledge in this critical field. We now propose to gain
further information about the biology of reproduction by using state-of-the-art postgenomic
functional approaches in our preclinical work. Our approach is based upon efficient transfer of
knowledge of gene function and dysfunction into clinical applications. In the long term we seek to
reduce the impact of reproductive disorders and demographic changes on European citizens and
their countrie's health care systems.
Additional document:
int_36904.pdf
Integrated biomedicine and functional genomics of the spectrin-associated cytoskeleton
Acronym :
PRO-SPECT
Organisation:
University of Kent
Contact person details
Title:
Dr
Gender:
M
Family Name:
Baines
First Name:
Anthony
Address:
Department of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK
Country:
Telephone N°:
E-mail:
United Kingdom
+44 1227 823462
Fax N°:
A.J.Baines@ukc.ac.uk
441227763912
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
Abstract:
The spectrin-associated cytoskeleton has a critical role in integrating individual cells into tissues.
Alterations to this protein complex are involved in the major diseases that affect the EU
population. In this integrated project, we will bring together selected leading European scientists to:
establish a comprehensive inventory of spectrin, ankyrin and protein 4.1 isoforms; identify
networks of protein interaction; manipulate gene expression; analyse regulation of function by
phosphorylation; analyse the spectrin-associated cytoskeleton in disease; develop pharmacological
approaches to disease states linked to the spectrin-associated cytoskeleton.
Key deliverables from this project are:
identification of function and regulation of proteins in the spectrin-associated cytoskeleton;
generation of antibodies to splice variants and phosphorylation-states of proteins in the
spectrin-associated cytoskeleton; training young scientists in modern functional genomics;
establishing a database of gene products and their interactions hyperlinked to other relevant
databases; developing screening technologies candidates in diseases
Additional document:
int_29485.pdf
Integrated Development of Methods in X-ray Crystallography
Acronym :
METHINX
Organisation:
University of Göttingen
Contact person details
Title:
Prof.
Gender:
Family Name:
SHELDRICK
First Name:
Address:
Department of Structural Chemistry
Tammannstraße 4
D-37077 Göttingen
Germany
Country:
Germany
Telephone N°:
49551393068
Fax N°:
E-mail:
gsheldr@shelx.uni-ac.gwdg.de
M
George
49551392582
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Abstract:
Macromolecular X-ray crystallography is universally recognised as an essential strategic
tool in post-genomic research. European contributions to its methodology and software
have been outstanding and not only constitute the backbone of the theoretical and practical
developments of the past, but are also playing a major role in the ongoing efforts to
assemble high-throughput (HT) structure determination capabilities. We propose that the
immediate goal of integrating the currently available software into technological platforms
oriented towards Structural Genomics should be accompanied by the longer-term goal of
integrating the activities of the research groups who wrote it within a Network of
Excellence, to speed up progress towards even more powerful HT platforms in the future.
By balancing curiosity-driven and goal-oriented activities, the Network will attract young
scientists to the field and help ensure that European crystallographers will continue to meet
the permanent challenge created by the exponential growth of structural biology.
Additional document:
int_29514.doc
Integrated mucosal protection networks stop ‘intruders’ and prevent major diseases
Acronym :
mucprovin
Organisation:
Lund University
Contact person details
Title:
Professor
Gender:
Family Name:
Carlstedt
First Name:
Address:
Lund University
Department of Cell and Molecular Biology
BMC/C13
SE-22184 Lund
Sweden
Country:
Sweden
Telephone N°:
+46 46 222 46 39
Fax N°:
E-mail:
ingemar.carlstedt@medkem.lu.se
M
Ingemar
+ 46 46 222 31 28
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
Mucprovin will be established as a virtual European Institute that by unravelling the regulatory
networks, molecular interactions and bio-complexity that control the fundamental biological
processes of mucosal protection – including host-pathogen interactions – will establish
conceptually new drug targets/preventive measures for several chronic diseases (e.g COPD,
asthma, CF, ulcerative colitis, peptic ulcers, ‘allergies’, oral dryness, cancer) as well as infectious
disease – conditions that have major socio-economic impact in the EU. In addition, improvement
of mucosal protection will diminish the effects of allergen/‘pollutant’/carcinogen exposure.
Cross-disciplinary collaborations, shared technology platforms and integration of basic and applied
research will provide a creative, synergy-prone environment and ensure that R&D results are
converted into useful economic and society benefits.
Additional document:
int_28963.doc
Integrated Project for Insect Systems Biology
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Department of Genetics
University of Cambridge
Downing Street
Cambridge CB2 3EH
UK
Country:
Telephone N°:
E-mail:
InSysBio
Department of Genetics, University of Cambridge
Dr
Russell
Gender:
First Name:
United Kingdom
+44 1223 766929
Fax N°:
s.russell@gen.cam.ac.uk
M
Steven
+44 1223 765202
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
Abstract:
This ambitious Project aims to integrate over 60 European research groups to develop and apply
state-of-the-art post genomics research tools. In order to effectively exploit the information locked
in genome sequences to improve basic science and generate economic output, the ESA needs to
consolidate research infrastructure. This proposal aims to coordinate the development of Systems
Biology tools, specifically those for genomics, proteomics, genetics and bioinformatics, for
applications in insect biology. By consolidating existing genomics expertise we shall develop a
platform for exploiting model insect systems, along with species of economic and medical
importance. Considerable research expertise, covering many aspects of biology, will utilise the
tools to further our understanding of basic biological processes with medical and agronomic
importance.
Additional document:
int_29738.pdf
Integrated Vaccines for Ticks and Tick-borne Pathogens
Acronym :
IV-TTP
Organisation:
Utrecht University, The Netherlands
Contact person details
Title:
Prof.dr.
Gender:
M
Family Name:
Jongejan
First Name:
Frans
Address:
Faculty of Veterinary Medicine, Department of Parasitology and Tropical Veterinary Medicine,
Yalelaan 1, 3508 TD Utrecht, The Netherlands
Country:
Telephone N°:
E-mail:
Netherlands
31302532568
Fax N°:
31 30 254 0784
F.Jongejan@vet.uu.nl ; tropicalticks@vet.uu.nl
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Globally, ticks and tick-borne diseases are major constraints to animal production, whereas in
Europe diseases transmitted by ticks constitute an increasing public health problem. The
development of vaccines against tick-borne diseases, but also against ticks is a sustainable
alternative to chemical tick control.
The availability of genomic sequence data and novel vaccine delivery systems has made it feasible
to construct multivalent DNA vaccines of bacterial, viral, and protozoan origin, combined with
anti-tick components.
To this end, European research efforts towards recombinant vaccines against ticks and tick-borne
diseases will be coordinated by the International Consortium on Ticks and Tick-borne Diseases
(ICTTD) Network of Excellence. The ambitious recombinant vaccine development program will
be carried out in an integrated project.
Additional sequence sequence data for the development of micro array analysis of ticks, hosts and
pathogens is required in order to fully exploit the various genomes and to identify genes from
proteomics data.
Additional document:
int_30459.pdf
Interaction Proteomics of Eukaryotic and Prokaryotic Cells
Acronym :
Interactome
Organisation:
University of Helsinki
Contact person details
Title:
Dr.
Gender:
F
Family Name:
Lankinen
First Name: Hilkka
Address:
Peptide and Protein Lab, Dep of Virology, Haartman Institute, P.O.Box 21 (Haartmaninkatu 3),
FIN-00014 University Of Helsinki, Finland
Country:
Finland
Telephone N°:
+358-(0)9-19126306
Fax N°:
+358-(0)9-191 26491
E-mail:
hilkka.lankinen@helsinki.fi
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
1.1.3 Nanotechnologies and nanosciences, knowledge-based multifunctional materials and new
production processes and devices
Abstract:
One of the major challenges of present research is in the function of human genes, which is linked
with the flourishing of new biotechnologies. Growing number of biological processes are being
described in terms of interacting proteins and their respective functions. At the present time also
interaction analyses flourish as functional proteomics research tools to provide mechanistic
descriptions of proteins within pathways of cellular and molecular processes. Interaction
proteomics is a bona fide research in promotion of innovations in structure-function based
biotechnologies of life science research, diagnostics, drug and vaccine development and gene
therapy. Yet, it will take a long time before biology or disease will be faithfully described in terms
of kinetic parameters, or reliably predicted from changes in primary sequences. Coherent efforts in
interactome research are called for.
Additional document:
int_29962.doc
Legionella pneumophila: from environmental habitats to disease pathology, detection and control
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Katholieke Universiteit Leuven
Rega Institute
Minderbroedersstraat 10, 3000
Leuven, Belgium
Country:
Telephone N°:
E-mail:
Legion
Katholieke Universiteit Leuven
Prof. Dr.
Anné
Gender:
First Name:
Belgium
3216337371
Fax N°:
jozef.anne@rega.kuleuven.ac.be
M
Jozef
3216337340
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Legionella pneumophila is an important emerging pathogen responsible for community-acquired
pneumonia. Infection is acquired through breathing aerosols of contaminated water. Although
Legionellae are fastidious bacteria to grow, they possess the ability t
Additional document:
int_30020.doc
Membrane Protein Structural Genomics
Acronym :
MePSGen
Organisation:
Chalmers University of Technology
Contact person details
Title:
Dr
Gender:
Family Name:
Bill
First Name:
Address:
Chalmers University of Technology
Department of Molecular Biotechnology
Box 462, 405 30 Göteborg, Sweden
Country:
Sweden
Telephone N°:
46317733923
Fax N°:
E-mail:
roslyn.bill@molbiotech.chalmers.se
F
Roslyn
46317733910
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Our consortium aims to integrate the activities of many of the world leaders in membrane protein
structural biology. We will develop methods and exchange laboratory and in silico tools aimed at
solving the structures of membrane proteins, which comprise more than 25% of known proteomes.
Specifically, we will streamline the heterologous production, purification and crystallisation of a
library of membrane proteins by elucidating the parameters responsible for success and failure at
each of these three key stages. In the process we will develop new technologies to overcome
existing bottlenecks peculiar to membrane protein structural genomics, which cannot be solved by
existing methods. A mobilisation of European expertise to address this timely issue will ultimately
contribute to understanding membrane protein-related human diseases such as cancer and
infections.
Additional document:
int_29934.pdf
MEMBRANE TRAFFICKING IN EUCARYOTIC ORGANISMS: FROM FUNCTIONAL
GENOMICS TO DISEASES
Acronym :
METEOR
Organisation:
CNRS and Institut Curie
Contact person details
Title:
Dr
Gender:
Family Name:
Goud
First Name:
Address:
UMR CNRS 144
Institut Curie,
26 rue d'Ulm, 75248 Paris Cedex 05, France
M
Bruno
Country:
Telephone N°:
E-mail:
(33) 142346382
France
(33) 142346398
bruno.goud@curie.fr
Fax N°:
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Membrane trafficking is a basic biological process in all eucaryots. It is essential for cell
compartmentalization, homeostasis, differentiation, and intra- and inter-cellular communication.
Alterations in these processes are involved in major pathophysiological conditions, including
diabetes, obesity, cancer, neurodegenerative, and infectious diseases. The Meteor network will
integrate the already extensive European membrane trafficking community to perform a
comprehensive analysis from molecules to function in different organisms at different levels of
complexity. It will deliver an accessible multi-dimensional model of membrane trafficking
processes in cells. This information is essential and will be used for the subsequent analysis of the
ethiology of diseases, the identification of novel drug targets, and the development of therapeutic
strategies.
Additional document:
Not available
Microbial diversity for Health
Acronym :
MD4Health
Organisation:
Katholieke Universiteit Leuven
Contact person details
Title:
Prof. Dr.
Gender:
Family Name:
Anné
First Name:
Address:
Rega Institute, Minderbroedersstraat 10, 3000 Leuven, Belgium
Country:
Telephone N°:
E-mail:
Belgium
3216337371
Fax N°:
jozef.anne@rega.kuleuven.ac.be
M
Jozef
3216337340
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.b Combating cancer
Abstract:
A novel approach to the molecular analysis of uncultured micro-organisms has recenty been
developed. This methodology, termed "Metagenomics" involves the construction of gene libraries
in appropriate vectors, followed by identification of genes of interes
Additional document:
int_29724.doc
Modelling Language for Systems Biology: Analysis, Simulation, Comparison, and Prediction
Acronym :
MoBydic
Organisation:
Università di Trento
Contact person details
Title:
Prof.
Family Name:
Priami
Address:
Dipartimento di Informatica e Telecomunicazioni
Via Sommarive 14
38050 Povo (TN)
Country:
Italy
Telephone N°:
+39 0461 882085
E-mail:
priami@dit.unitn.it
Gender:
First Name:
M
Corrado
Fax N°:
+39 0461 882093
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
We will design and implement an integrated computational environment which will allow
biologists to directly write computational models of complex molecular systems to edit, to analyse,
to compare, and to simulate the complex world of regulatory and metabolic pathways in different
tissues and organisms. This ultimate and ambitious goal follows a three step plan:
1. Development of a modelling language for systems biology fully equipped with a graphical
interface, allowing different level of abstraction and friendly, easy use by molecular biologists,
including representation of dynamic spatio-temporal behaviour, multiple molecular states forms
and interaction with the environment;
2. Development and of qualitative and quantitative methods for simulation and analysis based on
the computer science frameworks of process algebras, Petri nets and constraint programming;
3. Experimental validation and tuning of the computational environment.
Additional document:
int_36804.doc
Molecular and cellular biology of protein tyrosine phosphatases
Acronym :
PTP network
Organisation:
Universitätsklinikum Tübingen
Contact person details
Title:
Dr.
Gender:
Family Name:
Lammers
First Name:
Address:
Medical Clinic IV, Otfried-Müller Str. 10, 72076 Tübingen, Germany
Country:
Telephone N°:
E-mail:
Germany
4970712987599
Fax N°:
reiner.lammers@med.uni-tuebingen.de
M
Reiner
497071295974
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The current research on PTPs in Europe reflects the complicated nature of this enzyme class
and the basic research status that it still has. Although the sequencing of the human genome
and the vastly improved methods in protein research promise a major advance in many areas,
this will not be immediately helpful for the understanding of the regulation of PTPs. On the
other hand, with the first clinical studies initiated on PTP inhibitors, a rapid increase of
knowledge is required. Currently, each group working on PTPs has contacts to a few other
groups, and collaborations are mostly temporarily. Further, research on PTPs is carried out on
different biological backgrounds including areas as diverse as neuroscience, diabetes and
cancer. Being aware of the general knowledge deficit on basic aspects of PTP regulation,
most groups are willing to change this status.
Additional document:
int_29501.doc
Molecular characterization of modifier genes affecting mouse lymphoma development
Acronym :
Tumor modifier genes
Organisation:
UNIVERSIDAD AUTONOMA DE MADRID
Contact person details
Title:
Professor of Genetics, Ph.D
Gender:
M
Family Name:
Santos
First Name:
Javier
Address:
Departamento de Biología. Facultad de Ciencias. Universidad Autónoma de Madrid. Cantoblanco.
28049-Madrid. SPAIN
Country:
Telephone N°:
E-mail:
Spain
34-91-3978200
javier.santos@uam.es
Fax N°:
34-91-3978202
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
The present Expression of Interest intends to mobilise a critical mass of research activities and
technological development resources focuses on the understanding of the inherited predisposition
to those cancers ussualy considered sporadic, in particular lymphomas, but that may be affected
genetic factors whose role is point out by recent results of epidemiological studies and
experimental mouse models. The activities we plan to carry out in the context of an Integrated
Project aim at the characterization at the molecularlevel of genes that play a role as inherited risk
factors for lymphomas. To do this, we will use experimental mouse models of carcinogen-induced
thymic lymphomas, and the success of this kind of project would be based on the multidisciplinary
approach to the research tasks, from experimental cancer biology to advanced molecular genetic
techniques. The cloning of thymic modifier genes would be of a great relevance in terms of basic
cancer research because little is known about the genetic basis of cancer susceptibility. The
identification of modifier genes may be also important to the designing of new therapies for both
treatment and prevention of cancer
Additional document:
int_29640.doc
Molecular Mechanisms of Calcium Signalling in Health and Disease
Acronym :
EuroCalciumNet
Organisation:
University of Siena
Contact person details
Title:
Professor
Family Name:
Sorrentino
Address:
Sezione di Medicina Molecolare,
Dipartimento di Neuroscienze,
Università di Siena,
via Aldo Moro 5,
53100, Siena, Italy
Country:
Italy
Telephone N°:
39 0577 234 079
E-mail:
v.sorrentino@unisi.it
Gender:
First Name:
M
Vincenzo
Fax N°:
39 0577 234 191
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
Ca2+ signalling is a key process in the regulation of physiological and pathophysiological
conditions. Subtle structural and functional interaction between a multitude of different proteins is
responsible for the regulation of cellular Ca2+ signals in a cell-type dependent fashion. It is
therefore necessary to analyse and compare Ca2+ signalling in different cell types. The many
serious ailments caused by disregulation of Ca2+ signalling (including diabetes, heart and
circulatory diseases, ageing disorders, acute pancreatitis, cognitive processes) reduce the quality of
life and are, in many cases, life-threatening. By probing Ca2+ signalling in all its contexts, new
understanding of disease states will emerge that can lead to novel targets for therapeutic
intervention. This requires multi-disciplinary approaches and a combination of sophisticated
functional techniques. We therefore propose a Network of Excellence of 138 scientists working in
25 groups from 8 European countries.
Additional document:
int_30495.pdf
Molecular Mechanisms of Hormone Action and Clinical Implications of Their Disturbances
Acronym :
MOLMECHHORMACT
Organisation:
Vinca” Institute of Nuclear Sciences
Contact person details
Title:
Dr Res.Prof.
Gender:
Family Name:
Ribarac-Stepic
First Name:
Address:
”Vinca” Institute of Nuclear Sciences
Laboratory for Molecular Biology and Endocrinology
P.O. Box 522
11001 Belgrade
Yugoslavia
Country:
Serbia and Montenegro
Telephone N°:
+381 11 444 25 32
Fax N°:
E-mail:
nrs@rt270.vin.bg.ac.yu
F
Nevena
+381 11 455 561
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The study of insulin and steroid receptors as well as mediators involved in signal transduction of
these hormones and interaction between their signalling pathways on regulation of cell function
including regulation of gene expression, is the subject of this proposal. More specifically, the
mechanism of cell responses to ageing, stress, nonphysiological hormone concentrations as well as
pathophysiological states of the organisms (cancer, diabetes and other hormone dependent
diseases) will be investigated on the level of structural/functional modifications of the insulin and
steroid receptors, as well as mediators involved in their action. It will be also studied the role of
receptor systems in the interaction between different hormone action.
Additional document:
Not available
Molecular studies of selected nervous system disorders and diseases.
Acronym :
neuro-net
Organisation:
University of Oslo, Norway
Contact person details
Title:
Prof
Gender:
Family Name:
Andersson
First Name:
Address:
Department of Biochemistry, PO Box 1041 Blindern
NO 0316 Oslo
Norway
Country:
Norway
Telephone N°:
4722856625
Fax N°:
E-mail:
k.k.andersson@biokjemi.uio.no
M
K. Kristoffer
4722854443
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
Abstract:
The goal of this IP is to design new drugs for use in the treatment of major neurological/
psychiatric disorders including depression, schizophrenia, Parkinson's and Alzheimer's diseases.
The IP will study proteins that catalyze important steps in the biosynthesis/ regulation/release of
neurotransmitters or/and are involved in the function of synapses. The 2 SME and 19 partners will
examine the neurotransmitter systems of dopamine, glutamate, noradrenaline, NO, and serotonin,
including their receptors and downstream/upstream processing. The IP will analyze and modulate
all levels from sub-atomic level to biological function in cells/animals, with transgenic mice, and
explore genomic regulation of key processes. It will succeed to differentiate between some genetic
and environmental factors in neurological diseases. The IP will train scientist using a
multidisciplinary approach.
Additional document:
int_30509.doc
Multiorganismic Approach to Study Normal and Aberrant Muscle Development, Function, Ageing
and Repair
Acronym :
MYORES
Organisation:
Institut National de la Santé et de la Recherche Médicale (INSERM)
Contact person details
Title:
Dr
Gender:
M
Family Name:
JAGLA
First Name:
Krzysztof
Address:
INSERM U.384, 28, Place Henri Dunant 63000 Clermont-Ferrand
Country:
France
Telephone N°:
+33 473178181
Fax N°:
+33 473276132
E-mail:
Christophe.Jagla@u-clermont1.fr
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
Abstract:
The regulation of muscle development, function and repair is a widely represented field of
research that has accumulated an extensive body of information on a variety of organisms. Many
of the mechanisms governing myogenesis are evolutionarily conserved. The main goal of the
proposed Network is to take advantage of this conservation by creating a platform that allows the
rapid transfer and application of knowledge on muscle development and function. We aim to
exploit the growing body of genomic data and use the particular strengths of different animal
models to study the function of genes involved in muscle formation and muscle repair. MYORES
will serve to coordinate muscle studies across Europe, create efficient data banks and facilitate the
transfer of knowledge into specific applications for human muscle diseases and the development of
novel biotech initiatives.
Additional document:
int_29349.doc
Natural Product-like libraries for Use in Proteomics
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Auf der Morgenstelle 18
D-72076 Tübingen
Chemiomics
University of Tübingen, Institute of Organic Chemistry
Country:
Telephone N°:
E-mail:
Germany
4970712975247
Fax N°:
martin.e.maier@uni-tuebingen.de
Prof. Dr.
Maier
Gender:
First Name:
M
Martin E.
497071295137
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
1.1.1.ii.b Combating cancer
Abstract:
The aim of the joint project is to utilize natural product-like libraries for chemical genetics, probing
the function of proteins. Natural product-like compounds possess the necessary structural
complexity to interact selectively with proteins. The network will prepare libraries of natural
products by using the most advanced techniques in modern organic chemistry (solid phase
synthesis, solid-phase reagents, and combinatorial chemistry). The goals will be achieved by
investing in aspects of automation in chemistry and assay technology. The libraries will be very
useful for transcriptional profiling. It has already been shown by the group of Prof. Waldmann that
with such libraries an altered function can be achieved. The group of Prof. Ley developed the basic
synthesis tools to underpin this program. This way it should be possible to elucidate the language
of protein domains.
Additional document:
int_29825.doc
Nematode Genomics for Health
Acronym :
Organisation:
NemaGen
Institute of Molecular Biology and Biotechnology, Foundation for
Research and Technology
Contact person details
Title:
PhD
Gender:
M
Family Name:
Tavernarakis
First Name:
Nektarios
Address:
Institute of Molecular Biology and Biotechnology,
Foundation for Research and Technology,
Vassilika Vouton, P.O.Box 1527, Heraklion GR 71110, Crete, GREECE
Country:
Telephone N°:
E-mail:
Greece
30810391066
Fax N°:
tavernarakis@imbb.forth.gr
30810391101
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Biomedical research is in urgent need of tools and systems that will facilitate conversion of the vast
amounts of information in databases into tangible benefits for human health and quality of life.
Simple animal models, amenable to high-throughput approaches are required to accomplish this
goal. The nematode Caenorhabditis elegans has decisively contributed to our understanding of
numerous cellular and developmental processes and offers a unique platform with unmatched
strengths, ideal for comprehensive functional genomics applications. We propose to federate top
European laboratories with exceptional expertise in C. elegans biology, to carry out a systematic
genome-wide analysis of gene function at the organismal level. Our initiative will provide the
means to reveal and understand biological processes implicated in human disease and pathology,
and will directly contribute to the development of therapeutic intervention strategies by the
European biotechnology and pharmaceutical industry.
Additional document: Not available
Nerve Cell Simulator
Acronym :
NCellSim
Organisation:
Lay Line Genomics SpA
Contact person details
Title:
Prof.
Gender:
Family Name:
Cattaneo
First Name:
Address:
Via di Castel Romano, 100
00128 Roma
Italy
Country:
Italy
Telephone N°:
+39-6-80319053
Fax N°:
E-mail:
cattaneo@laylinegenomics.com
M
Antonino
+39-6-80319054
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The new available information on genomes and proteomes allow to figure genes and proteins as
parts of a complex network of interacting elements rather than as isolated entities. A molecular
function becomes then a function of cellular context and not only an individual property of single
proteins. Current efforts for the analysis of protein-protein interactions are the first steps for the
construction of molecular interactions networks.These qualitative networks provide the basis for
the quantitative simulation of the time evolution of a protein network at the whole cell level.The
proposed Integrated Project aims to realize a “Nerve Cell Simulator” (NCellSim)through a
European-wide effort produced by major public Research Institutions, as well as private
companies. The main scientific outcome of the project will consist in the creation of an integrated
in silico model of an entire human neuronal cell, built on the bases of existing and purposely
acquired biochemical and biophysical experimental data. Aside to that, NCellSim will also define a
"general protocol", i.e. the complete set of methods and tools able to extend this activity to the
simulation of other types of human cells.
Additional document:
int_29340.doc
Network on Molecular Epidemiology of Malaria
Acronym :
INMEM
Organisation:
Instituto de Higiene e Medicina Tropical
Contact person details
Title:
Prof.
Gender:
Family Name:
do Rosário
First Name:
Address:
IHMT, Dept. Centro Malária Doenças Tropicais
Rua da Junqueira, 96
1349-008 Lisboa
Portugal
Country:
Telephone N°:
E-mail:
Portugal
++ 351213622458
cmdt@ihmt.unl.pt
Fax N°:
M
Virgilio E.
351213622458
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.1.ii.c Confronting the major communicable diseases linked to poverty
Abstract:
The present inability to keep malaria under control is due to a number of different known factors.
Research on basic biology and genotyping of the parasite and its hosts (human and the mosquito
vector), including host/parasite interactions is essential to the understanding of mechanisms
leading to control programmes. The formation of the present network aims at a multi-factorial
research approach, including expertise in pre-erythrocytic/erythrocytic cycle of the parasite,
host-parasite interactions, monitoring diverse aspects of the infection in relation to the
disease/morbidity and mortality. The utilisation of rodent malaria models will be pursued. In
addition, the development of new antimalarials and vaccine formulations is also envisaged.
Collaboration with research in other Protozoa in strongly considered due to similarities in research
approaches and control programmes.
Additional document:
int_28889.doc
Additional document:
int_28889.doc
Neurogen: A genome -based analysis of brain development
Acronym :
NEUROGEN
Organisation:
Ecole Normale Supérieure
Contact person details
Title:
Dr
Gender:
Family Name:
ROSA
First Name:
Address:
Groupe Danio, U368 INSERM
Biologie Moléculaire du développement
46, rue d’Ulm
F-75230 PARIS cedex 05
Country:
France
Telephone N°:
33 1 44 32 39 78
Fax N°:
E-mail:
rosa@wotan.ens.fr
M
Frédéric
33 1 44 32 39 88
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
Abstract:
This EoI proposes a network of excellence centred on nervous system development. Understanding
how the genome shapes the brain is the most challenging task of functional genomics and
underpins progress in combating neurological and psychiatric diseases. The network will put
together the leading European research centres and laboratories working on this topic. They
combine the expertise (genetics, genomics, cell biology, embryology, anatomy, physiology),
animal models (man, mouse, chick, Xenopus, Drosophila, C. elegans) and technology platforms
required. The network will have the critical mass to centralise resources, training and outside
communication in the field in Europe and to become a leading competitor world wide.
Additional document:
Not available
NEUROPEPTIDES IN BRAIN THEORY, BEHAVIOUR AND PATHOGENESIS OF DISEASE
Acronym :
EUROPEP
Organisation:
UNIVERSITY OF LIVERPOOL
Contact person details
Title:
PROFESSOR
Gender:
Family Name:
QUINN
First Name:
Address:
Chair of Neurobiology
Physiological Laboratory & Dept Human Anatomy and Cell Biology
Crown St
University of Liverpool
Liverpool L69 3BX
Country:
United Kingdom
Telephone N°:
441517945498
Fax N°:
E-mail:
JQUINN@LIV.AC.UK
M
JOHN
441517945517
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
The objectives of the EUROPEP network is a European coordinated and interdisciplinary
investigation of the molecular and cellular regulation and function of neuropeptides and their
receptors. We would also validate the emerging clinical genomic and polymorphic data of
neuropeptide association with disease. Thus:
1) improve the basic understanding, diagnosis and treatment of diseases in which neuropeptides
play a significant role including nervous system disorders such as Alzheimer’s and Parkinson
diseases, epilepsy, brain tumours, depression but also lung disease, cardiovascular disease, the
dysregulation of the neuro-immune axis, obesity, diabetes mellitus type 2, cancer, gastrointestinal
disease.
2) to foster the development of therapeutic systems and designed drug discovery, in cooperation
2) to foster the development of therapeutic systems and designed drug discovery, in cooperation
with biotechnology and pharmaceutical companies.
3) to create an advanced brain theory on the basis of the neuropeptides' huge number of degrees of
freedom in coding and memory spaces
Additional document:
int_29888.doc
New Methods in Biomedical Imaging and Diagnostics for functional Genomics
Acronym :
NEMBI
Organisation:
ENEA, Ente per le Nuove tecnologie, l’Energia e l’Ambiente
Contact person details
Title:
Dr
Gender:
M
Family Name:
Gallerano
First Name:
Gian Piero
Address:
UTS – Tecnologie Fisiche Avanzate
Via Enrico Fermi 45 00044 Frascati, Italy
Country:
Telephone N°:
E-mail:
Italy
-390694005223
Fax N°:
gallerano@frascati.enea.it
-390694005334
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Looking into the inside of living organisms has been a major challenge since the early stage of
biological and biomedical research. It can provide fundamental information about the structural
and functional properties of such systems starting from a macroscopic scale to reach increasingly
deeper microscopic details. Electromagnetic radiation has proven to be a fundamental tool in this
process and, over the years, it has literally shed new light onto a variety of biological systems by
providing spectroscopic tools and non-invasive techniques for biomedical diagnostics. With this
Expression of Interest we propose an Integrated Project on the development and combination of
new methods in biomedical imaging and diagnostics for functional genomics, which include
fundamental research in portions of the electromagnetic spectrum not yet fully explored, such as
the Terahertz range, lying between the Microwave and Infrared regions, and the Soft X-ray region.
Selective information about structural and functional properties of increasing complexity can be
achieved by exploiting the specific spectroscopic fingerprints of biological systems in these
frequency ranges.
Additional document:
int_29835.doc
NEW SYNTETIC VECTORS IN GENE THERAPY - SYNVEGET
Acronym :
SYNVEGET
Organisation:
University of Parma43100 Parma- Italy
Contact person details
Title:
Prof
Gender:
Family Name:
Fisicaro
First Name:
Address:
Dipartimento di Scienze Farmacologiche, Biologiche e Chimiche Applicate
Università di Parma
Parco Area delle Scienze 27/A
43100 Parma - Italy
Country:
Italy
Telephone N°:
+39 521 905028 (9050
Fax N°:
E-mail:
Fisicaro@unipr.it
F
Emilia
+39 521 905026
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
This integrated project is devoted to the synthesis, chemico-physical, and structural characterization
of newly synthesized vectors, particularly cationic surfactants, both monomeric and gemini, and to
the evaluation of their biological activity and potentiality of application as vectors in gene therapy.
Gene therapy, in the mind of many researchers, could change the face of the medicine and of the
pharmaceutical industry in this new century: the researches in this field are therefore very relevant
in the international framework. Recently, the interest in cationic surfactants has grown up, because
cationic liposomes are now recognised as a potent means to assist the delivery of gene and nucleic
acids to cells. This open the very interesting possibility that cationic liposomes could play a major
role in the future as a core technology in the emerging field of gene therapy
Additional document:
int_29600.doc
Novel gene regulatory mechanisms: Oligopeptide-encoding and non-coding RNAs
Acronym :
sORF-RNAs
Organisation:
Institut des Sciences du Végétal
Contact person details
Title:
Ph.D.
Gender:
Family Name:
Crespi
First Name:
Address:
Institut des Sciences du Végétal-CNRS
1 Avenue e la Terrasse
91198 Gif sur Yvette
Country:
France
Telephone N°:
33 1 69823703
Fax N°:
E-mail:
crespi@isv.cnrs-gif.fr
M
Martin
33 1 69823695
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Small RNAs and oligopeptides are emerging as key partners in novel regulatory mechanisms
controlling gene expression and signalling in eukaryotes. Genes encoding them (mRNAs
containing ORFs smaller than 100 aminoacids or sORF-RNAs) constitute a significant unexplored
portion of the eukaryotic genome. The present project aims to identify sORF-RNA genes in
arabidopsis, zebrafish and mouse and explore their role and cellular targets using the large genetic
and genomic resources available in arabidopsis. European partners with expertise in peptide/RNA
biology, bioinformatics, functional genomics and industrial exploitation of genomes will come
together to develop novel post-genomic technologies, based on oligopeptide or small RNA
molecules, for the control of growth, differentiation and responses to environmental challenges.
Additional document:
int_36859.doc
OLIVES –DEVELOPING TOOLS FOR SUSTAINABLE CROP IMPROVEMENT DURING
GLOBAL CHANGE
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Biotechnology Unit
School of Applied Sciences
University of Glamorgan
Trefforest
CF37 1DL, United Kingdom
Country:
Telephone N°:
E-mail:
NEWOLIVE
University of Glamorgan, Treforest, Wales, UK
Prof
Murphy
Gender:
First Name:
United Kingdom
44 14 43 48 37 47
Fax N°:
dmurphy2@glam.ac.uk
M
Denis Joseph
44 14 43 48 22 85
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
Abstract:
We will establish the first truly Europe-wide network of research and development on olive crops
and their improvement for new markets. The immediate aim is to form a cohesive EU program to
develop scientific tools in order to offset the serious emerging effects of global change on olive
crops in the Mediterranean region. We will develop advanced molecular tools to enable breeders to
introduce new olive cultivars with enhanced drought tolerance and, ultimately, improved oil
yield/quality parameters. The eventual aim is to work with producers, processors and distributors in
order to use our technology to launch a vibrant new olive export industry to satisfy the emerging
markets in North America and East Asia.
Additional document:
int_31464.doc
Open Reading Frames for European Union Scientists
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Ihnestr. 73
14195 Berlin, Germany
ORFEUS
Max Planck Institute for Molecular Genetics
Country:
Telephone N°:
E-mail:
Germany
+49 30 8413 1221
Fax N°:
lehrach@molgen.mpg.de
Prof. Dr.
Lehrach
Gender:
First Name:
M
Hans
+49 30 8413 1380
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
To manage large collections of proteins it is practical to store clones containing each
corresponding Open Reading Frame (ORF). From ORF clones, proteins can be synthesised in any
cell type or expressed as translational fusions with any peptide moieties. Cloned ORF
complements representing all proteins expressed in an organism (ORFeomes) are necessary for
functional proteomics research but are not yet available. Their construction is now possible via
novel recombinational cloning techniques. Based on a network of EU labs directly involved in
ORF cloning from human and other metazoan species, our objectives are to organise collaborative
efforts for the construction of large ORF collections improving the cost effectiveness of European
research funding and to disseminate widely materials and expertise for the exploitation of ORF
resources (see http://www.psb.rug.ac.be/orfeus).
Additional document:
int_30261.doc
PHOTOsensors and light signal transduction: functional GENomics/proteomics in photosynthetic
organisms
Acronym :
PHOTOGEN
Organisation:
Max-Planck-Institut fuer Strahlenchemie
Contact person details
Title:
Professor Dr.
Gender:
Family Name:
Gaertner
First Name:
Address:
Max-Planck-Institut fuer Strahlenchemie
Stiftstr. 34-36, D-45470 Muelheim, Germany
Country:
Germany
Telephone N°:
X49-208-3063693
Fax N°:
E-mail:
gaertner@mpi-muelheim.mpg.de
M
Wolfgang
X49-208-3063951
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6.1.i Research activities having an impact in the short and medium term
Abstract:
Light perception is of paramount importance for plants and microbes to regulate growth,
movement, biological rhythms, and photosynthetic performance and to ensure ecological fitness of
agricultural plants (harvest index, nutritional quality). Research on photosensory receptors is highly
interdisciplinary, requiring expertise in academic and and applied sciences. US and Japan have
been leading, up to now, in this research area, by bringing together basic research and applied
technology. Europe has highly qualified laboratories which, however, collaborate only
occasionally. The purpose of this EoI is to bring together these laboratories in an Integrated
Project. An activity as outlined in this proposal can, due to its complexity and interdisciplinary
character, only be envisaged on the level of the European Community. The expected outcome of
this proposal will reveal outstanding information on light-induced processes in biology. The results
from this collaborative effort will be of importance for the agricultural and pharmacological
European companies and will contribute to maintain the high standard of food production in
Europe.
Additional document:
int_29912.doc
Plant Cell Signaling
Acronym :
PCS
Organisation:
Ecole Normale Supérieure de Lyon
Contact person details
Title:
Dr
Gender:
Family Name:
GAUDE
First Name:
Address:
Ecole Normale Supérieure
Reproduction et Développement des Plantes
46, Allée d'Italie 69364 Lyon Cedex FRANCE
Country:
France
Telephone N°:
33472728609
Fax N°:
E-mail:
thierry.gaude@ens-lyon.fr
M
Thierry
33472728600
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6.1.i Research activities having an impact in the short and medium term
Abstract:
The aim of this "Plant Cell Signaling" project is to better our understanding of the diverse cell
communication mechanisms that control growth and development, stress (biotic and abiotic)
responses and sexual reproduction in plants. The federating element
Additional document:
int_30338.doc
Population genomics
Acronym :
Population genomics
Organisation:
Université Paris-6 “Pierre et Marie Curie”, Paris, France
Contact person details
Title:
Professor
Gender:
M
Family Name:
Veuille
First Name:
Michel
Address:
Population genetics group
Laboratoire d’Ecologie Cc 237
Université Pierre et Marie Curie
7 quai saint Bernard,
75252 Paris cedex 05, France
Country:
France
Telephone N°:
+ 331 4427 2631
Fax N°:
+ 331 4427 3516
E-mail:
mveuille@snv.jussieu.fr
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6.3 Global Change and ecosystems
Abstract:
Population genomics is the study of the forces that determine patterns of DNA variation in
populations. These forces include mutation, recombination, genetic drift, transposition, natural
selection, genetic conflicts, and the demographic history of species. The full sequencing of the
genomes of several model organisms will for the first time allow us to evaluate the role of these
factors in genome evolution. This knowledge will play a critical part in the success of programmes
attempting to characterise genes responsible for complex diseases, for the improvement of
domestic species, and for the management of natural resources in conservation biology. The
network will use two kinds of instruments: shared genomic data will integrate and structure
research in Europe; a summer school, along with mobility and training actions, will spread basic
knowledge inside and outside the network.
Additional document:
int_28911.pdf
Pre- and post-meiotic gene expression in spermatogenic arrests
Acronym :
Organisation:
Male gonad
Institute of Human Genetics Polish Academy of ScienceUnit of
Reproductive Biology
Contact person details
Title:
Prof.
Family Name:
Kurpisz
Address:
Strzeszynska 32, 60-479 Poznan, Poland
Country:
Telephone N°:
E-mail:
Gender:
First Name:
Poland
48618233011
Fax N°:
kurpimac@man.poznan.pl
M
Maciej
48618233235
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
Abstract:
Spermatogenesis is a complex process of cell development, differentiation and maturation. Two
opposite biological forces are in operation with a common task to deliver a functionally active male
gamete, i.e. proliferation vs apoptosis. Finally, only 20%
Additional document: int_30393.doc
Prediction and Analysis of Folding and Sequence-structure-Function Relations of Proteins and
Protein Complexes
Acronym :
STRFUNGEN
Organisation:
Koc University
Contact person details
Title:
Professor
Family Name:
Erman
Address:
College of Engineering, Dept. of Mech Engineering
Koc University
80910 Sariyer, Istanbul Turkey
Country:
Turkey
Telephone N°:
(90)212 338 1704
E-mail:
berman@ku.edu.tr
Gender:
First Name:
M
Burak
Fax N°:
(90)212 338 1548
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i Advanced genomics and its applications for health
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
The project aims to develop fundamental knowledge and to obtain novel, fast and working tools for
predictions and analysis of proteins and protein complexes with the collaboration of
inter-disciplinary research groups. The main objectives of the project are: (i) to predict secondary
and tertiary protein structure and contact maps, (ii) to improve the analysis of the inverse folding
problem, (iii) to develop the problems of protein classification and gene and protein repositories,
(iv) to study cellular processes, and (v) to analyze dynamics of proteins during folding into the
native state and in the folded state. The outcome of the project will be: production of software,
organization of training courses and workshops and possibly initiation and development of
collaboration with the industry.
Additional document:
int_36511.doc
Production of Transgenic Livestock using Nuclear Transfer as Human Disease Model
Acronym :
Transgenic Livestock
TUBITAK,Research Institute for Genetic Engineering and Biotechnology,
Organisation:
Transgenic and ESC Core Facility, Gebze-Kocaeli, Turkey
Contact person details
Title:
Dr.
Gender:
F
Family Name:
Arat
First Name:
Sezen
Address:
TUBITAK,Research Institute for Genetic Engineering and Biotechnology, Transgenic and ESC
Core Facility, 41470 Gebze-Kocaeli, Turkey
Country:
Telephone N°:
E-mail:
Turkey
90-262-6412300
sezen@rigeb.gov.tr
Fax N°:
90-262-6412309
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
Genetically modified livestock have important implication for agriculture and human medicine.
The birth of calves following nuclear transfer (NT) with cultured transgenic fetal cell lines
demonstrates the possibility of producing cloned transgenic cattle.Since the mouse model is
insufficient in many case the main objective of the project is to produce transgenic livestock
models which can be better model than murine,and show similar symptoms of human diseases and
have temporal and spatial embryonic development similar to that of human,and a longer lifespan
than murine, in order to get more information on the mechanism of human diseases and improve
new therapeutic strategies,by using nuclear transfer of genetically manipulated somatic cells.
Additional
Additional
document:
int_30056.doc
Programmed Cell Death Across Kingdoms
Acronym :
TransDeath
Organisation:
University of Copenhagen, Denmark
Contact person details
Title:
Prof
Gender:
Family Name:
Mundy
First Name:
Address:
Institute of Molecular Biology, University of Copenhagen
Oester Farimagsgade 2A, 1353 Copenhagen K, Denmark
M
John
Country:
Telephone N°:
E-mail:
45 35322128
Denmark
4535322131
mundy@biobase.dk
Fax N°:
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
Cells may die by genetically defined, programmed cell death (PCD) invoked during development
or in defense against pathogens. TransDeath aims to produce knowledge on genes and biochemical
processes that regulate PCD in different organisms, and to apply that knowledge to develope
strategies and targets for human disease therapy. TransDeath objectives include: - Characterize the
diversity of genes & biochemicals controlling PCD- Functionally compare these genes &
biochemicals between organisms- Derive genetic & functional models of PCD evolution- Test
genes & biochemicals on cell growth & PCD related to human disease- Develope drug discovery
& applications for selected genes & biochemicals
Additional document:
int_28946.pdf
Protein Folding and Disease
Acronym :
Organisation:
ERFOLD
Università Vita-Salute San Raffaele Scientific Institute, DiBiTVia
Olgettina 58. 20132 Milano Italy
Contact person details
Title:
Prof
Gender:
Family Name:
Sitia
First Name:
Address:
Università Vita-Salute, DiBiT San Raffaele Scientific Institute
via Olgettina 58
20132 Milano Italy
Country:
Italy
Telephone N°:
+39 02 2643 4763
Fax N°:
E-mail:
r.sitia@hsr.it
M
Roberto
390226434723
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
Abstract:
Recently, two novel classes of human diseases have entered textbooks: Conformational Diseases
and Endoplasmic Reticulum Storage Diseases. Their pathogenesis involves alterations in the
pathways of protein folding, intracellular transport and degradation. The tightening links with
medicine are opening a new challenge for European top cell-biology laboratories. The main aims
of this proposal are i) to integrate our basic studies on the folding and quality control of secretory
proteins in the ER, ii) to rapidly translate results into an understanding of the proteins or
mechanisms that are involved in human diseases or have therapeutic potentials and iii) to create
new open research spaces able to attract and train medical staff.
Additional document: int_30361.doc
Protein folding-misfolding: from theory to therapy
Acronym :
Protein (mis)folding
Organisation:
University of Granada
Contact person details
Title:
Dr
Gender:
Family Name:
Conejero-Lara
First Name:
Address:
Department of Physical Chemistry, Faculty of Sciences
Av. Fuentenueva s/n, 18071, Granada, Spain
M
Francisco
Country:
Telephone N°:
E-mail:
34958272879
Spain
34958242371
conejero@ugr.es
Fax N°:
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Understanding the mechanism of protein folding remains a true grand challenge for post-genomic
research. Previous (1996-2001) and present (2002-2005) TMR Networks on protein folding and
misfolding have set the seed for a more ambitious integration of researchers under the 6th
framework to achieve the following general goals: i) to understand in detail the relationships
between folding kinetics, folding mechanism and structure; ii) to explore the evolutionary basis for
natural selection of protein sequences and avoidance of aggregation and fibril formation; iii) to
characterise folding intermediates and their relationship with species involved in initiating protein
or peptide aggregation; iv) to investigate the structure of early of early pre-fibrillar and mature
fibrillar aggregates; v) to explore the mechanisms underlying aggregate toxicity to living systems.
Additional document:
int_29507.doc
Protein kinases - novel drug targets of post genomic era
Acronym :
PROTKINDRUGS
Organisation:
University of Helsinki
Contact person details
Title:
Professor
Gender:
M
Family Name:
Tuominen
First Name:
Raimo
Address:
Drug Discovery Technology Center and Division of Pharmacology and Toxicology, Department of
Pharmacy, P.O.Box 56, FIN-00014
University of Helsinki, Helsinki, FINLAND
Country:
Finland
Telephone N°:
+358919159469
Fax N°:
+358919159471
E-mail:
raimo.tuominen@helsinki.fi
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
1.1.1.ii.b Combating cancer
Abstract:
European expertise in basic research on protein kinases and rational drug discovery based on
natural compounds will be integrated to strengthen the impact of the EU as a major contributor to
improving the treatment of major disabling diseases such as cancer and chronic inflammatory
diseases. The consortium will apply the most advanced methods in basic research and drug
discovery in order to find new protein kinase inhibitors and/or activators with potential as novel
therapeutics. Natural compounds found from the European biosphere will be analysed for their
structure – activity relationship and will be used as model drugs or templates for rational drug
discovery. Also new technologies for drug discovery will be developed and research on the role of
protein kinases in the regulation of physiological and pathophysiological phenomena pertinent to
the aforementioned diseases will be pursued.
Additional document:
int_36517.doc
Protein Structure Prediction
Acronym :
ProteinPredictor
Organisation:
Structural Chemistry, Stockholm University
Contact person details
Title:
Prof.
Gender:
M
Family Name:
Hovmöller
First Name:
Sven
Address:
Structural Chemistry, Stockholm University
SE_106 91 Stockholm, Sweden
Country:
Telephone N°:
E-mail:
Sweden
468162380
svenh@struc.su.se
Fax N°:
468163118
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
The leading European research groups in the closely connected fields of fold recognition,
homology modelling, ab-initio protein structure predictions, de novo design of proteins and
protein-protein docking will integrate their efforts in this network. We
Additional document:
int_29938.doc
Proteins in cells: structure, folding and interactions in crowded environments
Acronym :
CROWD
Organisation:
University of Barcelona
Contact person details
Title:
Prof
Gender:
Family Name:
Pons
First Name:
Address:
Departament de Química Orgànica
Martí i Franqués, 1-11
08028- Barcelona
SPAIN
Country:
Telephone N°:
E-mail:
Spain
+34 934021263
mpons@qo.ub.es
Fax N°:
M
Miquel
+34 933397878
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
The aim of the project is the exploitation of European expertise in the emerging area of the study of
the structure, energetics, dynamics and function of protein assemblies, protein-protein interactions
and protein folding in macromolecularly crowded media resembling the physiological
environment.
This project will i) provide a solid basis for the use of structural information, obtained by structural
genomics consortia, in the interpretation of in vivo experiments, ii) facilitate the development of
efficient structure-driven in vivo drug screening assays and iii) establish an interdisciplinary body
of theory and experiments that could uncover emerging properties of proteins and protein networks
at high concentrations or in confined/crowded environments.
Additional document:
int_30441.pdf
RdRp : a key enzyme in the genomic and post-genomic era
Acronym :
Organisation:
RNApolGeneControl
UniversityClaude Bernard Lyon 1 & Centre National de la Recherche
Scientifique UMR5537
Contact person details
Title:
Dr
Gender:
Family Name:
Gerlier
First Name:
Address:
CNRS-UCBL UMR5537 Virologie et Pathogénèse Virale
Faculté de Médecine Lyon RTH Laennec
69372 LYON CEDEX 08, France
Country:
France
Telephone N°:
33478778618
Fax N°:
E-mail:
gerlier@laennec.univ-lyon1.fr
M
Denis
33478778754
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
RNA is the source of biological information for highly pathogenic viruses and for cellular
post-transcriptional silencing of gene expression, where RNA-dependant-RNA-polymera-ses
(RdRp) play a key role. The aim is to establish the structure-function relationship of viral and
cellular RdRps, their handling of the (nucleoprotein:)RNA template and their regulation by viral
and/or cellular cofactors. The resulting basic knowledge will allow to design new antiviral drugs
and new RdRp-derived therapeutic tools. The multidisciplinary approach includes several virus
and cell RdRp models, high throughput technologies for 3D structure and proteomic analysis,
anti-RdRp chemicals screening and large scale bioinfor-matic. A durable EU Integrated laboratory
network will ensure the long term coordinated and complementing research in the field of the
RNA-driven genetic information
Additional document: int_29064.doc
Redesigning Photosynthesis for an Uncertain Future: Enhancing Productivity, Using Scarce
Resources more Effectively, and Protecting the Environment
Acronym :
REDESIGN
Organisation:
University of Sheffield
Contact person details
Title:
Professor
Gender:
Family Name:
Leegood
First Name:
Address:
Robert Hill Insitute
Department of Animal and Plant Sciences
University of Sheffield
Sheffield
S10 2TN
Country:
United Kingdom
Telephone N°:
+44 114 222 0040
Fax N°:
E-mail:
r.leegood@sheffield.ac.uk
M
Richard
+44 114 222 0050
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.6.3 Global Change and ecosystems
1.1.5 Food Quality and Safety
1.1.6.3 Global Change and ecosystems
Abstract:
The aim of this proposal is to establish Europe as the major centre for the redesign of crop plants,
particularly cereals, to reduce inputs (fertilizers, irrigation), to increase yield under stress by
enhancing tolerance of crop plants to high temperature, high light, drought and salinity, and to alter
cereal grain composition (carbohydrates, proteins and amino acids). This will involve the
identification of novel genes and traits and their application to transformation and breeding of
cereal crops. Beneficiaries will include the EU Farming Industry, Water Industry, Raw Materials
Manufacturers, Human Health/Nutrition Organisations, Food Processing Industries and
Environmental Protection Agencies, as well as EU regions in which climate currently precludes
commercial production of cereals.
commercial production of cereals.
Additional document:
int_36754.doc
Reliable processing of next generation thermal barrier coating systems
Acronym :
Organisation:
RELIABLE NEW TBCs
Forschungszentrum Jülich GmbH,Institut für Werkstoffe und Verfahren
der Energietechnik 1
Contact person details
Title:
Dr.
Family Name:
Vaßen
Address:
Forschungszentrum Jülich GmbH
IWV 1, D-52425 Jülich
Country:
Germany
Telephone N°:
++49 2461 61 6108
E-mail:
r.vassen@fz-juelich.de
Gender:
First Name:
M
Robert
Fax N°:
++49 2461 61 2455
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
Abstract:
In gas turbines, efficiency and hence further reduction of fuel consumption, is dependent upon an
increasing extent on performance and reliability of thermal barrier coating (TBC) systems. The
standard TBC material, yttria stabilized zirconia, is close to its maximum operating temperature, so
new designs and new systems with enhanced high temperature capability have been investigated.
However, even for the standard TBC system, knowledge on failure mechanisms and reliable
processing requires to be improved. The aim of this proposal is to achieve a break through for the
most relevant issues: reliable processing in combination with advanced monitoring systems and
development of new TBCs. A new generation of TBC systems with negligible scatter of properties
with reliable life time prediction methods, monitoring systems for remaining life time prediction,
and enhanced performance is envisaged.
Additional document:
Not available
RICE EXCELLENCE NETWORK WITHIN THE EUROPEAN UNION
Acronym :
EURICEN
Organisation:
CONSEJERIA DE AGRICULTURA, AGUA Y MEDIO AMBIENTE
Contact person details
Title:
Dr.
Gender:
F
Family Name:
PASCUAL-VILLALOBOS
First Name: MARIA JESUS
Address:
CIDA, Estación Sericícola
C/ Mayor s/n
30150 La Alberca
MURCIA, SPAIN
Country:
Spain
Telephone N°:
34-968-366768
Fax N°:
34-968-366792
E-mail:
MJesus.Pascual@carm.es
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
1.1.6.3 Global Change and ecosystems
Abstract:
Rice is a unique case within Europe. On the one hand it holds a global importance as a model
organism for genomic research. On the other, it is a crop of regional (mediterranean) importance
for a multifunctional and sustainable agriculture to produce quality foods. A proposal to establish a
Network of Excellence covering all aspects of rice and a recommendation that rice be mentioned
clearly within the priorities of the Sixth Framework Programme is made by this Expression of
Interest.
Additional
document:
int_28055.doc
RNA metabolism: Arabidopsis as a model for basic eukaryotic processes
Acronym :
RNA-MET
Organisation:
Scottish Crop Research Institute, Dundee, Scotland, UK
Contact person details
Title:
Dr.
Gender:
M
Family Name:
Brown
First Name: John W. S.
Address:
Scottish Crop Research institute, Invergowrie, Dundee, DD2 5DA, Scotland, UK
Country:
United Kingdom
Telephone N°:
+44-1382-562731
Fax N°:
+44-1382-568503
E-mail:
jbrown@scri.sari.ac.uk
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
Abstract:
Many human diseases are caused by mutations in RNA metabolism processes or components of
RNA-protein complexes or nuclear bodies. To understand the complexity of interactions in RNA
metabolism, and, for example, in alternative splicing, generic and specific approaches are required.
Model organisms are essential to dissecting basic processes as they provide comparative
phylogenetic information and opportunities for experimentation which is difficult to conduct in
humans. At the level of RNA metabolism, plants have many similarities to humans in terms of
mechanisms, components and nuclear organisation. Arabidopsis has advantages for global
expression studies of co-ordinated and inter-linked expression, whole genome alternative splicing,
and the function of orthologous proteins involved in a variety of human diseases due to defects in
RNA metabolism.
Additional document:
int_28868.doc
SECONDARY METABOLISM, PRIMARY INTEREST!Elucidation principles regulation plant
secondary metabolism
Acronym :
PlantChemoDiversity
Organisation:
Leiden University
Contact person details
Title:
Prof. dr.
Gender:
M
Family Name:
Verpoorte
First Name:
Robert
Address:
Division of Pharmacognosy, Leiden/Amsterdam Center for Drug Research
PO Box 9502, 2300 RA Leiden The Netherlands
Country:
Telephone N°:
E-mail:
Netherlands
31715274528
Fax N°:
Verpoort@lacdr.leidenuniv.nl
31715274511
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
Biodiversity is our richest natural resource. It is an important source of chemodiversity, which
supplies us with e.g. medicines, flavors, fragrances, insecticides and dyes. Secondary metabolites
produced in plants play also an important role for our heal
Additional document:
Not available
Signal Transduction Pathways in Plants
Acronym :
Signaling
Organisation:
Institute of Experimental Botany, AS CR
Contact person details
Title:
Prof.
Gender:
Family Name:
Machackova
First Name:
Address:
Rozvojova 135, 16502 Praha 6
Czech Republic
Country:
Czech Republic
Telephone N°:
+420220390453
Fax N°:
E-mail:
machackova@ueb.cas.cz
F
Ivana
+420220390456
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6.3 Global Change and ecosystems
Abstract:
Plant growth and development is under the control of multiple signaling pathways. It includes
response, at the level of cells, organs and whole plant, to both internal (phytohormones) and
external (temperature, light, elicitors) signals. Signaling pathways include receptors, second
messengers, changes in ion fluxes, protein kinases, synthesis or activation/deactivation of
transcription factors. They occur partly at the membranes, partly in cytosol or organelles and some
signaling molecules can intercat with cytoskeleton. There is an extensive crosstalk among
individual pathways. The aim of the proposed Network is to concentrate research in this field in
Europe to obtain detailed characterization of signaling pathways and molecular mechanisms of
their cross-talk. This knowledge is crucial for plant biotechnologies, sustainable agriculture and
reforestation.
Additional document:
int_38204.doc
SIGNIFICANCE AND POPULATION IMPACT OF GENE-ENVIRONMENT INTERACTIONS
FOR HUMAN DISEASE
Acronym :
Organisation:
INTERGENE
FONDAZIONE I.S.I. - ISTITUTO PER L'INTERSCAMBIO
SCIENTIFICO
Contact person details
Title:
Prof.
Family Name:
VINEIS
Address:
Viale Settimio Severo nr. 65 - 10133 Torino Italy
Country:
Telephone N°:
E-mail:
Gender:
First Name:
Italy
390116603090
Fax N°:
epidemiology@isi36a.isi.it
M
Paolo
390116600049
Applicable Instrument: Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
Abstract:
With the Human Genome Project and similar large-scale initiatives for the decoding of the human
genome, many potential candidate genes for the study of the role of genetics and gene-environment
interactions (GEI) in human disease will emerge. The present
Additional document: int_29014.doc
Single Molecule Techniques for Cell Biology and Ultra-sensitive Diagnostics
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Leiden Institute of Physics
Niels Bohrweg 2
2333 CA LEIDEN
The Netherlands
Country:
Telephone N°:
E-mail:
SMT-CBUD
Leiden University
Prof. Dr.
Oosterkamp
Gender:
First Name:
M
Tjerk
Netherlands
+31-71-5275424
tjerk@phys.leidenuniv.nl
Fax N°:
+31-71-5275404
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.3.i Nanotechnologies and Nanosciences
Abstract:
Cancer, cardiovascular and inflammatory diseases, osteoporosis (and other skeletal disorders) as
well as viral pathogenic infections represent an area of major clinical need and are therefore of key
clinical and biotechnological interest. Cell function and disfunction is regulated and controlled by
directed macro-molecular transport within the cell. In these processes the non-random lateral
distribution of lipids and proteins in a membrane plays a major role. Recently developed single
molecule microscopy techniques allow to directly follow the movement of membrane components
and to study the transport and binding of transporter molecules in situ during cellular processes.
This will give novel insights into the regulation of cellular processes on the single molecule level
and lead to new diagnostic and therapeutic strategies.
Additional document:
Not available
SOX GENES AND CONTROL OF DEVELOPMENT
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Vojvode Stepe 444a
POBOX 446
11 000 Belgrade
Yugoslavia
SOX
Institute of Molecular Genetics and Genetic Engineering
Country:
Telephone N°:
E-mail:
Serbia and Montenegro
-381113976212
Fax N°:
stevanov@eunet.yu
Dr
Stevanovic
Gender:
First Name:
F
Milena
-381113975808
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
Abstract:
SOX genes comprise a family of transcriptional regulators implicated in the control of
development and differentiation. The evidences for developmental importance of SOX genes
come from mutation analysis of patients with developmental disorders as well as from
experiments when SOX genes were subjected to target deletion strategy.Presently, little is
known about the SOX genes function and ways by which those genes exert their roles in
control of development and differentiation. Studying the transcriptional regulation of SOX genes
expression will contribute, not only in understanding signalling pathways that involve SOX
genes, but also may contribute in understanding molecular mechanisms leading to
various human developmental disorders as the basis for development diagnostics and
therapeutic methods.
Additional document:
int_30423.doc
Standard for the scoring of arousals in children
Acronym :
Arousals in children
Organisation:
European Pediatric Wake-Up Club
Contact person details
Title:
Professor
Gender:
M
Family Name:
Kahn
First Name:
André
Address:
University Children’s Hospital Queen Fabiola, Av.J.J Crocq 15; B-1020 Brussels, Belgium
Country:
Belgium
Telephone N°:
32.2.477.3237
Fax N°:
32.2.477.2755
E-mail:
akahn@ulb.ac.be
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii Combating major diseases
Abstract:
The scoring of arousals from sleep is an important step in the evaluation of various clinical
problems in newborns (e.g. the determination of the neurologic state), infants (e.g. the Sudden
Infant Death Syndrome) and in children (e.g. insomnia). Scoring of arousals is done with the use of
polygraphic techniques. The evaluation of the propensity to arouse from sleep is important both for
research purposes and for clinical decisions. The scoring of arousals from sleep in adult subjects
relies on the guidelines edited by the American Sleep Disorders Association. No similar guidelines
are available for children, for whom the adult guildelines are not adequate. The European Pediatric
Wake-Up club has been established to address these issues. The Club will determine age-specific
guidelines for newborns, infants and children through its network of expert sleep centres.
Additional document:
Not available
Stem Cell Activation and Maintenance in Meristems
Acronym :
EU-STAMM
Organisation:
Max Planck Institute for Developmental Biology
Contact person details
Title:
Prof. Dr.
Gender:
M
Family Name:
Weigel
First Name:
Detlef
Address:
Max Planck Institute for Developmental Biology
Department of Molecular Biology
Spemannstrasse 37-39/VI
D-72076 Tuebingen
Country:
Germany
Telephone N°:
+49-7071-601 1411
Fax N°:
+49-7071-601 1412
E-mail:
weigel@weigelworld.org
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
Abstract:
Stem cells are the ultimate source of cells in organ development and regeneration of multicellular
organisms. The potential to produce diverse cell types is not an intrinsic property but rather
depends on the cellular context. Understanding how stem cells are established and maintained by
signals from neighbouring cells has far-reaching implications not only for reproductive biology but
also for potential applications. Europe is currently a leader in plant stem cell research, and an
integrated project, EU-STAMM, is proposed to maintain and strengthen European competence in
this area. EU-STAMM will have several clusters that will combine expertise reaching from
developmental biology to genomics platforms and mathematical modelling. Academic excellence
will be leveraged through the involvement of at least two plant functional genomics companies.
Additional document:
int_36433.pdf
Structural Genomics of Metalloproteins: Function and Mis-function
Acronym :
SGEMET
Organisation:
Abteilung StrukturforschungMax-Planck Institut für Biochemie
Contact person details
Title:
Prof
Gender:
M
Family Name:
Messerschmidt
First Name:
Albrecht
Address:
Am Klopferspitz 18 A
Planegg-Martinsried D-82152
GERMANY
Country:
Germany
Telephone N°:
498985782669
Fax N°:
498985783516
E-mail:
messersc@biochem.mpg.de
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
SGEMET aims to mobilise European research groups involved with 'age-related' disease,
metalloproteins structure-function research and high throughput structural determination
approaches (technical as well as methodological). Through this integration of effort across Europe
of some 12 major institutions (50 PIs with over 300 scientists) SGEMET will strengthen the
European competitiveness in Structural Genomics and address one of the most socially relevant
health issue of 'age-related diseases'.
Metalloproteins are involved in many disease states including ageing processes and are a special
class of proteins that are thought to make up ~30% of the genome and are not being addressed
specifically in the current high throughput programmes worldwide. Special approaches are needed
for structural genomics study of these proteins.
Additional document:
Not available
Sustainable Improvement in Nutrition Value and Quality of Cereal Grains
Acronym :
Organisation:
Contact person details
Title:
Family Name:
Address:
Department of Plant Biology
Research Centre Flakkebjerg
Forsøgsvej 1
DK-4200 Slagelse
susipep
Danish Institute of Agricultural Sciences
Country:
Telephone N°:
E-mail:
Denmark
45 58 11 35 79
Fax N°:
eva.vincze@agrsci.dk
dr
vincze
Gender:
First Name:
F
eva
45 58 11 33 01
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.5 Food Quality and Safety
Abstract:
The aim of the project is to fill the developing gap in the supply and demand for high quality
protein for human food and animal feed within Europe. This will promote and assist the move of
agriculture to a more sustainable platform, reduce the dependence on imported protein and thereby
increase European competitiveness with respect to the USA. This will be achieved by exploiting
natural genetic diversity, plant molecular biology tools and resources developed within the
European community for the model plant Arabidopsis over the last 15 years.
It is expected that by incorporating Arabidopsis, with its short growth cycle into a cereal-breeding
program, the time taken to develop the initial breeding lines exhibiting enhanced protein utilisation
and improved nutrition quality will be significantly reduced.
Additional document:
int_38087.doc
The EuroGlycomics Network: functional genomics and exploitation of polysaccharide metabolism
Acronym :
EuroGlycomics
Organisation:
The Royal Veterinary and Agricultural University
Contact person details
Title:
Prof.
Gender:
M
Family Name:
Scheller
First Name:
Henrik
Address:
Department of Plant Biology, 40 Throvaldsensvej,
DK-1871 Frederiksberg C, Copenhagen, Denmark
Country:
Denmark
Telephone N°:
-4535283354
Fax N°:
-4535283333
E-mail:
hvs@kvl.dk
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.3.ii Knowledge-based Multifunctional Materials
1.1.5 Food Quality and Safety
1.1.6 Sustainable development, global change and ecosystems
Abstract:
Cell walls made of complex carbohydrates are a unique feature of plants, bacteria and fungi and
they have many roles related to human health. The polysaccharides of the plant cell wall are
synthesized by means of a large number of enzymes, but very few of these have been identified at
the gene level. The Network assembles leading European groups with expertise in cell wall
metabolism and analytical methods to elucidate cell wall biogenesis. The objectives of the Network
is to define function of genes involved in cell wall metabolism, particularly biosynthesis.
Furthermore, the Network will determine biological function of polysaccharide features in human
health, food quality, and plant physiology and development. Finally, the Network will support
industrial exploitation of complex carbohydrates in pharmaceutical and food industry.
Additional document:
Not available
The Meso-telencephalic Telencephalic Dopamine Consortium
Acronym :
DopaNet
Organisation:
INSTITUT PASTEUR
Contact person details
Title:
Professeur
Family Name:
Changeux
Address:
Récepteurs et Cognition
Institut Pasteur
25, rue du Dr Roux
75724 Paris cedex 15, France
Country:
France
Telephone N°:
+33-1-45-68-88-05
E-mail:
lenov@pasteur.fr
Gender:
First Name:
M
Jean-Pierre
Fax N°:
+33-1-45-68-88-36
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The aim of this proposal is to mobilise the european scientific expertise in molecular and cellular
neurobiology, in order to investigate precisely and quantitatively all the aspects of
neurotransmission --- at the levels of the molecule, the supra-molecular assembly, the neuronal cell
and the neuronal network --- in a specific neuronal system, involved in many neuropathologies,
such as Parkinson's disease, schizophrenia and drug abuse. The resulting integrated knowledge will
not only provide relevant, up-to-date information, methods and tools for the diagnosis and
treatment of such pathologies, but also form a firm substrate to link the function of the
neurobiological structures and the implementation of cognitive and mental abilities.
Additional document:
int_30436.pdf
The Mouse as a Tool to Study the Alterations of Energy Homeostasis:Diabetes, Obesity, Energy
Expenditure and the Metabolic Syndrome
Acronym :
EndocrinoMOUSE
Organisation:
Université Libre de Bruxelles
Contact person details
Title:
Dr
Gender:
Family Name:
Schurmans
First Name:
Address:
IRIBHM, IBMM, ULB
CP300
12, rue des Professeurs Jeener et Brachet
6041 Gosselies
Belgium
Country:
Telephone N°:
E-mail:
Belgium
3226509825
sschurma@ulb.ac.be
Fax N°:
M
Stéphane
3226509820
Applicable Instrument:
Network of Excellence
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii Combating major diseases
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
The overall theme of this proposal is the application of co-ordinate efforts and expertises in the
generation and phenotyping of genetically-modified mouse models to improve the understanding
of the in vivo molecular mechanisms underlying human diseases characterized by alterations in
'energy homeostasis'. Specifically, our programme will focus on the molecular basis of insulin
resistant type 2 diabetes, obesity, energy expenditure and thyroid diseases, all of them integrated
under the concept of the 'metabolic syndrome'. As a network, our efforts will be directed to
increase our capabilities in the generation and phenotyping of new mouse models for these
diseases.
Additional document:
int_29671.doc
The Yeast Silicon Cell: a molecular systems biology approach
Acronym :
YSiC
Organisation:
Università degli Studi di Milano-Bicocca
Contact person details
Title:
Prof.
Gender:
F
Family Name:
Alberghina
First Name:
Lilia
Address:
Dipartimento di Biotecnologie e Bioscienze, Università degli Studi di Milano-Bicocca Piazza della
Scienza, 2 I-20126 Milano
Country:
Italy
Telephone N°:
+390264483515
Fax N°:
+390264483519
E-mail:
lilia.alberghina@unimib.it
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1 Genomics and biotechnology for health
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Abstract:
Computer models and in silico experiments are required to integrate the information delivered by
post-genomic techniques, the ultimate goal being to reproduce in silico the major properties of the
life cycle of the chosen model cell. This IP proposes a concerted European effort towards the first
computer replica of the organism for which more advanced technological tools are available, the
yeast Saccharomyces cerevisiae, to serve as a model for (in silico) human cell biology. The IP will
deliver a silicon cell of interest for the biotechnological industry to accelerate drug discovery and
to improve fermentation of rationally engineered strains. Distinguished yeast groups willing to
participate in collecting quantitative biochemical, genetic and physiological data as well as systems
engineers interested to implement these in the Yeast Silicon Cell are welcome to the initiative.
Additional document:
int_28997.doc
Therapeutic Modulation of Heat Shock - Chaperone Genes
Acronym :
TMCG
Organisation:
DIBIT - San Raffaele Scientific Institute
Contact person details
Title:
Dr. med
Gender:
M
Family Name:
Zimarino
First Name:
Vincenzo
Address:
Department of Molecular Biology and Functional Genomics
DIBIT - San Raffaele Scientific Institute
Via Olgettina 58
20132 Milano
Country:
Italy
Telephone N°:
39 2 2643 4896
Fax N°:
39 2 2643 4844
E-mail:
zimarino.enzo@hsr.it
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
In model organisms, individual Chaperone transgenes have been shown to modify disease-like
phenotypes caused by "protein misfolding" mutations, regardless of the identity of the disease
protein, providing a strong rationale and renewed interest for therapeutic exploitation. Augmenting
Chaperone activities requires the ability to control expression of multiple endogenous genes,
mainly because Chaperone systems depend on cooperation of distinct types of molecules which are
naturally co-induced. It is proposed to integrate the research of ten European laboratories with
expertises in : a)transcriptional regulation of Heat Shock - Chaperone genes, b)activities of
Chaperone proteins, c)transgenic animal models of genetically defined misfolding diseases, in
order to produce the knowledge, systems and reagents on which the development of flexible
strategies for Chaperone-mediated therapy can rely.
Additional document:
int_37515.pdf
Transport processes in filamentous fungi, their regulation and energetic aspects
Acronym :
Organisation:
Fungmetrans
Slovak University of Technology, Faculty of Chemical and Food
Technology, Department of Biochemistry and Microbiology
Contact person details
Title:
Dr. Assoc. Prof.
Family Name:
VARECKA
Address:
Radlinského 9, 812 37 – Bratislava 1, Slovakia
Country:
Slovakia
Telephone N°:
**421 2 49325 514
E-mail:
varel@chtf.stuba.sk
Gender:
First Name:
M
Ludovít
Fax N°:
**421 2 5249 3198
Applicable
Integrated Project
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
Abstract:
Filamentous fungi are saprophytic organisms capable living on numerous complex substrates.
Obviously, they have to possess adaptive metabolic and transport pathways which should enable to
exploit various available substrates. The information about these pathways is a pre-requisite for
their future genetic modification. Unfortunately, the knowledge of the metabolic and transport
pathways in filamentous fungi is far from exhaustive and scattered among many species. The aim
of the project would be to study the utilisation of selected substrates and to follow their fate by
NMR methods and/or radioactivity, the study of adaptations to non-standard substrates, to study the
changes of expression of genes associated with these pathways, and to find a relationship between
the substrate transport and the activation of the metabolism using selected fungal species.
Additional
document:
int_29299.doc
TRANSPOSABLE ELEMENT GENOMICS
Acronym :
TRANSGENOMICS
Organisation:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
Contact person details
Title:
PROF
Gender:
M
Family Name:
DERAGON
First Name:
JEAN-MARC
Address:
CNRS UMR6547, UNIVERSITE BLAISE PASCAL, BIOMOVE, 24 AVENUE DES LANDAIS,
63177, AUBIERE CEDEX
Country:
France
Telephone N°:
(0)473407752
Fax N°:
(0)473407777
E-mail:
J-MARC.DERAGON@GEEM.UNIV-BPCLERMONT.FR
Applicable
Network of Excellence
Instrument:
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.6.3 Global Change and ecosystems
Abstract:
The aim of this proposal is to establish Europe as the international scientific leader in genomic
database exploitation by concentrating a critical mass of research (160 full time scientists/year) on
the major component of genomes: the transposable elements (TEs). This project will produce the
new bioinformatic tools and databases on TEs that are urgently needed to correctly exploit the
huge amount of sequencing data generated by various genomic projects and to better integrate
post-genomic research into biomedical and biotechnological approaches. This network would give
European biotechnology industries a critical leading edge to exploit the full potential of genome
information to underpin applications to human health. The proposed work will also impact
fundamental understanding of processes generating human mutations and diseases and will provide
part of the knowledge needed to evaluate the impact of environmental changes on biodiversity.
Additional
int_29007.pdf
document:
XML based modeling language for stadartization of describing biological systems
Acronym :
ModML
Organisation:
Technion- Israel Institute of Technology
Contact person details
Title:
Professor
Gender:
M
Family Name:
Adam
First Name:
Dan
Address:
Department of Biomedical EngineeringTechnion - I.I.T.Haifa 32000, Israel
Country:
Israel
Telephone N°:
97248294140
Fax N°:
97248234131
E-mail:
dan@biomed.technion.ac.il
Applicable Instrument:
Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.2.ii Communication, computing and software technologies
1.1.2.iv Knowledge and interface technologies
Abstract:
An Expression-of-Interest is presented, to develop an Integrated Project for a custom-built
computer language, specifically for modeling (termed ModML). The beauty of such a common
language is that it will enable various models - describing different biological systems and levels
(genetic, molecular, cellular or organ) – to interact with each other, and thus provide composite
systems and simulations. Currently, several XML-based modeling languages are being developed
to facilitate Web-based sharing and the transfer of biological/structural models. It is the vision and
aim of the IP to incorporate their standards and concepts into the ModML which will be designed
to incorporate the objects, rules, and vernacular of different disciplines and modeling ontologies
(anatomy, histology, reaction pathways, governing equations of physical processes, etc) into a
common framework.
Additional document:
int_36586.pdf
Zebrafish Models for Human Development and Disease
Acronym :
ZF-MODELS
Organisation:
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Contact person details
Title:
Dr.
Gender:
M
Family Name:
Geisler
First Name:
Robert
Address:
Department III - Genetics, Max-Planck-Institut für Entwicklungsbiologie,
Spemannstr. 35/III, D-72076 Tübingen, Germany
Country:
Telephone N°:
E-mail:
Germany
497071601443
Fax N°:
robert.geisler@tuebingen.mpg.de
497071601384
Applicable Instrument: Integrated Project
Sub-Thematic Priority most relevant to your topic:
1.1.1.i.a Fundamental knowledge and basic tools for functional genomics in all organisms
Other relevant Sub-Thematic Priorities:
1.1.1.i.b Applications of knowledge and technologies in the field of genomics and biotechnology
for health
1.1.1.ii.a Application-oriented genomic approaches to medical knowledge and technologies
1.1.1.ii.b Combating cancer
1.1.5 Food Quality and Safety
Abstract:
We aim to combine the advantages of the zebrafish in mutagenesis screening and developmental
biology with recent advances in functional genomics, in an integrated high-throughput project for
the benefit of human health and basic research. Fish transgenic for Green Fluorescent Protein
(GFP) will be used to produce tissue-specific cDNA libraries and probes by cell sorting. Tissueand stage-specific gene expression will be systematically profiled. Mutants will provide entry
points into regulatory pathways, which will be followed up by knock-down (morpholino injection)
or targeted knock-out of downstream genes. Related species will be analysed for evolutionary
comparisons. In situ, microarray, phenotypic and proteomic data will be integrated in a public
database that will let us model regulatory networks in development, and apply this knowledge to
human disease.
Additional document:
int_30038.doc