Tamilselvan Jayavelu, Ph.D
Assistant Professor
Centre for Biotechnology
Anna University, Chennai – 600 025
India
Phone : +91-44-22358381
Fax
: +91-44-22358381
E.mail : tamilselvan@annauniv.edu
EDUCATION
DEGREE
Ph.D – Biochemistry
M.Sc – Biochemistry
B.Sc – Biochemistry
UNIVERSITY
Department of Medical Biochemistry, University of Madras
Department of Medical Biochemistry, University of Madras
University of Madras
YEAR
2003 – 2008
2000 – 2002
1997 – 2000
RESEARCH EXPERIENCE
POSITION/UNIVERSITY/DEPARTMENT
AREA OF RESEARCH
YEAR
Postdoctoral fellow
Medical University of South Carolina
Dept of Pharmaceutical & Biomedical Sciences,
Charleston, SC, USA
Mitochondrial biogenesis signaling
during oxidant injury
2009 - 2010
Postdoctoral fellow
University of Pennsylvania
Department of Animal Biology, Philadelphia,
PA, USA
Mitochondrial – to – nucleus stress
signaling
2008 – 2009
Doctor of philosophy
University of Madras
Department of Medical Biochemistry
Taramani Campus, Chennai – 600113, India
Mitochondrial dysfunction and skeletal
muscle apoptosis during aging
2003 – 2008
RESEARCH INTERESTS
1. Molecular mechanism(s) of Insulin Resistance.
2. Molecular mechanisms of aging process and degenerative diseases
CURRENT RESEARCH
Dysregulation of autophagy as a possible mechanism of insulin resistance: Organelles dysfunction
are often associated with insulin resistance in various cell types, including muscle and adipose tissue. However,
it is uncertain whether organelles dysfunction is a cause or consequence of insulin resistance. Since defective
organelles are usually cleared off by a process called autophagy and it is negatively influenced by insulin, we
hypothesize that the chronic hyperinsulinemia (associated with obesity and type 2 diabetes) may inhibit
autophagy and, thus, adipose tissue dysfunction and development of insulin resistance.
RESEARCH PUBLICATIONS
AUTHOR/TITLE/JOURNAL INFORMATION
1 Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG (2010). 5-hydroxytryptamine receptor
stimulation of mitochondrial biogenesis. J Pharmacol Exp Ther 332 (2), 632-639.
2 Tamilselvan J, Jayaraman G, Sivarajan K, Panneerselvam C (2007). Age dependent upregulation of p53 and
cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: Role of carnitine
and lipoic acid. Free Radic Biol Med 43(12), 1656-1669.
3 Tamilselvan J, Sivarajan K, Anusuyadevi M, Panneerselvam C (2007) Cytochrome c Oxidase Rather than
Cytochrome c is a Major Determinant of Mitochondrial Respiratory Capacity in Skeletal Muscle of Aged
Rats: Role of Carnitine and lipoic Acid. Rejuvenation Res 10(3), 311-326.
4 Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C (2005) Oxidative stress on mitochondrial
antioxidant defense system in the aging process: role of DL-α-lipoic acid and L-carnitine. Clin Chim Acta
355: 173-180.
5 Samuel S, Kathirvel R, Jayavelu T, Chinnakkannu P (2005) Protein oxidative damage in arsenic induced rat
brain: influence of DL-α-lipoic acid. Toxicol Lett 155: 27-34.