E. James Petersson University of Pennsylvania
University of Pennsylvania
Department of Chemistry
231 South 34 th Street
Philadelphia, PA 19104-6323
Email: ejpetersson@sas.upenn.edu
Website: ejpweb1.chem.upenn.edu
Phone: (215) 746-2221
CV current as of: 09/17/2014
Current Position
July 2008 - Present
January 2013 - Present
Academic Experience
July 2005 - June 2008
June 1999 - June 2005
University of Pennsylvania
Assistant Professor, Department of Chemistry
Perelman School of Medicine, University of Pennsylvania
Secondary Appointment, Biomedical Graduate Studies Group
Yale University
Postdoctoral Fellow with Prof. Alanna Schepartz
California Institute of Technology (Caltech)
Ph.D. 2005, Graduate Fellow with Prof. Dennis Dougherty
June 1995 - June 1998 Dartmouth College
B.A. 1998, Undergraduate Research Assistant with Prof. David M. Lemal
(Dartmouth College), Prof. G. Barney Ellison (University of Colorado), and Dr.
George Radzisewski (National Reusable Energy Labs)
Awards and Honors
University of Pennsylvania 2013 Journal of Physical Organic Chemistry Early Excellence Award
2012 Sloan Research Fellow
2012 NSF CAREER Award
2012 Chemical Communications – Emerging Investigator
2010 Searle Scholar
Yale University NIH/NIGMS Kirschstein Individual Postdoctoral Fellow
2006 Bioorganic Gordon Research Conference - outstanding poster
Caltech NIH/NINDS Kirschstein Individual Predoctoral Fellow
2005 Herbert Newby McCoy Award – outstanding graduate research
2002 Outstanding Chemistry Graduate Teaching Assistant
Dartmouth College 1998 Chandler T. White Prize – outstanding senior thesis
1998 Tarbell Organic Chemistry Book Prize
Rufus Choate Scholar
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E. James Petersson University of Pennsylvania
Professional Affiliations
American Chemical Society Member since 1998
Biophysical Society Member since 2001
New York Academy of Sciences Member since 2007
Pennsylvania Organic Chemist’s Club Member since 2009
Protein Society Member since 2006
Society for Biological Engineering Member since 2010
Publications (36 manuscripts, 679 citations, H-index 16)
* Authors contributed equally to the manuscript.
Peer Reviewed: Independent (18 manuscripts, 133 citations)
30. Strategies for Labeling α -Synuclein with Small Molecule Fluorophores and Assessing Their Impact on
Amyloidogenesis Warner, J. B.*; Wang, Y. J.*; Wissner, R. F.; Petersson, E. J.; In Preparation .
29. Inteins as traceless purification tags for unnatural amino acid proteins Batjargal, S.; Walters, C. R.;
Petersson, E. J.; Submitted .
28. Surface Effects Mediate Self-Assembly of Amyloid-beta Peptides Lin, Y.-C.; Petersson, E. J.; Fakhraai, Z.
ACS Nano In Press .
URL: http://dx.doi.org/10.1021/nn5031669
27. Specific Modulation of Protein Activity Through a Bioorthogonal Reaction Warner, J. B.; Muthusamy, A. K.;
Petersson, E. J. ChemBioChem In Press .
URL: http://dx.doi.org/10.1002/cbic.201402423
26. Characterization of the Lipid Binding Properties of Otoferlin Reveal Specific Interactions Between PI(4,5)P2 and the C2C and C2F Domains Padmanarayana, M; Hams, N.; Speight, L. C.; Petersson, E. J.; Mehl, R. A.;
Johnson, C. P. Biochemistry 2014 , 53 , 5023 - 5033.
URL: http://dx.doi.org/10.1021/bi5004469
25. Thioamide-Based Fluorescent Protease Sensors Goldberg, J. M.; Chin, X. S.; Meinhardt, N.; Greenbaum, D.
C.; Petersson, E. J. J. Am. Chem. Soc.
2014 , 136 , 2086 – 2093.
URL: http://dx.doi.org/10.1021/ja412297x
24. Synthesis of Thioester Peptides for the Incorporation of Thioamides into Proteins by Native Chemical
Ligation Batjargal, S.; Huang, Y.; Wang, Y. J.; Petersson, E. J. J. Peptide Sci.
2014 , 20 , 87 – 91.
URL: http://dx.doi.org/10.1002/psc.2589
Included in J. Peptide Sci . 2013 Chemical Protein Synthesis Meeting Issue.
23. Efficient Synthesis and In Vivo Incorporation of Acridonylalanine, a Fluorescent Amino Acid for Lifetime and Förster Resonance Energy Transfer/Luminescence Resonance Energy Transfer Studies Speight, L. C.;
Muthusamy, A. K.; Goldberg, J. M.; Warner, J. B.; Wissner, R. F.; Willi, T.; Woodman, B.; Mehl, R. A.;
Petersson, E. J. J. Am. Chem. Soc.
2013 , 135 , 18806 – 18814.
URL: http://dx.doi.org/10.1021/ja403247j
22. Thioamide Quenching of Fluorescent Probes Through Photoinduced Electron Transfer: Mechanistic Studies and Applications Goldberg, J. M.; Batjargal, S.; Chen, B. S.; Petersson, E. J. J. Am. Chem. Soc.
2013 , 135 , 18651
– 18658.
URL: http://dx.doi.org/10.1021/ja409709x
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E. James Petersson University of Pennsylvania
21. Efficient, Traceless Semi-Synthesis of α -Synuclein Labeled with a Fluorophore/Thioamide FRET Pair
Wissner, R. F.; Wagner, A. M.; Warner, J. B.; Petersson, E. J. Synlett 2013 , 24 , 2454 – 2458.
URL: http://dx.doi.org/10.1055/s-0033-1339853
Included in Synlett 2013 EuCheMS Young Investigator Workshop Issue.
20. Molecular Basis for Amino-Terminal Acetylation by the Heterodimeric NatA Complex Liszczak, G.;
Goldberg, J. M.; Petersson, E. J.; Arnesen, T.; Marmorstein, R. Nat. Struct. Mol. Biol.
2013 , 20, 1098 - 1105.
URL: http://dx.doi.org/10.1038/nsmb.2636
19. Expressed Protein Ligation at Methionine: N-terminal Attachment of Homocysteine, Ligation, and Masking
Tanaka, T.; Wagner, A. M.; Warner, J. B.; Wang, Y. J.; Petersson, E. J. Angew. Chem. Int. Ed . 2013 , 52 , 6210-
6213.
URL: http://dx.doi.org/10.1002/anie.201302065
18. Labeling Proteins with Fluorophore/Thioamide FRET Pairs by Combining Unnatural Amino Acid
Mutagenesis and Native Chemical Ligation Wissner, R. F.; Batjargal, S.; Fadzen, C. M.; Petersson, E. J. J. Am.
Chem. Soc. 2013 , 135 , 6529 – 6540.
URL: http://dx.doi.org/10.1021/ja4005943
17. Native Chemical Ligation of Thioamide-Containing Peptides: Development and Application to the Synthesis of Labeled α -Synuclein for Misfolding Studies Batjargal, S.; Wang, Y. J.; Goldberg, J. M.; Wissner, R. F.;
Petersson, E. J. J. Am. Chem. Soc . 2012 , 134 , 9172 - 9182.
URL: http://dx.doi.org/10.1021/ja2113245
“Spotlighted” in J. Am. Chem. Soc . 2012 , 134 , 6499. Selected for the cover of J. Am. Chem. Soc .
16. Minimalist Probes for Studying Protein Dynamics: Thioamide Quenching of Selectively-Excitable
Fluorescent Amino Acids Goldberg, J. M.; Speight, L. C.; Fegley, M. W.; Petersson, E. J. J. Am. Chem. Soc .
2012 , 134 , 6088 - 6091.
URL: http://dx.doi.org/10.1021/ja3005094
15. Thioamide Quenching of Intrinsic Protein Fluorescence Goldberg, J. M.; Wissner, R. F.; Klein, A. M.;
Petersson, E. J. Chem. Commun.
2012 , 48 , 1550 - 1552.
URL: http://dx.doi.org/10.1039/c1cc14708k
Included in Chem . Commun . 2012 Emerging Investigator Issue.
14. A Simple Chemoenzymatic Method for N-Terminal Protein Modification Wagner, A. M.; Fegley, M. W.;
Warner, J. B.; Grindley, C. L. J.; Marotta, N. P.; Petersson, E. J. J. Am. Chem. Soc.
2011 , 133 , 15139–15147.
URL: http://dx.doi.org/10.1021/ja2055098
13. Thioamides as Fluorescence Quenching Probes: Minimalist Chromophores to Monitor Protein Dynamics
Goldberg, J. M.; Batjargal, S.; Petersson, E. J. J. Am. Chem. Soc.
2010 , 132 , 14718-14720.
URL: http://dx.doi.org/10.1021/ja1044924
Peer Reviewed: Undergraduate, Graduate, and Postdoctoral (12 manuscripts, 518 citations)
12. Toward β -Amino Acid Proteins: Design, Synthesis, and Characterization of a 15-Kilodalton β -Peptide
Tetramer Petersson, E. J.; Schepartz, A. J. Am. Chem. Soc.
2008 , 130 , 821-823.
URL: http://dx.doi.org/10.1021/ja077245x
11. Biophysical and Structural Characterization of a Robust Octameric β -Peptide Bundle Goodman, J. L.;
Petersson, E. J.; Daniels, D. S.; Qiu, J.; Schepartz, A. J. Am. Chem. Soc.
2007 , 129 , 14746-14747.
URL: http://dx.doi.org/10.1021/ja0754002
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E. James Petersson University of Pennsylvania
10. Biophysical Characterization of a β -Peptide Bundle: Comparison to Natural Proteins Petersson, E. J.; Craig,
C. J.; Daniels, D. S.; Qiu, J.; Schepartz, A. J. Am. Chem. Soc . 2007 , 129 , 5344-5345.
URL: http://dx.doi.org/10.1021/ja070567g
9. High Resolution Structure of a β -Peptide Bundle Daniels, D. S.; Petersson, E. J.; Qiu, J.; Schepartz, A . J. Am.
Chem. Soc . 2007 , 129 , 1532-1533.
URL: http://dx.doi.org/10.1021/ja068678n
8. Toward β -Amino Acid Proteins: A Cooperatively Folded β -Peptide Quaternary Structure Qui, J.; Petersson,
E. J.; Matthews, E. E.; Schepartz, A. J. Am. Chem. Soc . 2006 , 128 , 11338-11339.
URL: http://dx.doi.org/10.1021/ja063164+
7. Probing the Mg 2+ Blockade Site of the NMDA Receptor with Unnatural Amino Acid Mutagenesis
McMenimen, K. A.; Petersson, E. J.; Lester, H. A.; Dougherty D. A. ACS Chem. Biol . 2006 , 1 , 227-234.
URL: http://dx.doi.org/10.1021/cb6000944
6.
Caged Phosphoproteins Rothman, D. M.; Petersson, E. J.; Vasquez, M. E.; Brandt, G. S.; Dougherty, D. A.
Imperiali, B. I. J. Am. Chem. Soc.
2005 , 127 , 846-847.
URL: http://dx.doi.org/10.1021/ja043875c
5.
Using Physical Chemistry to Differentiate Nicotinic from Cholinergic Agonists at the Nicotinic Acetylcholine
Receptor Cashin, A. L.; Petersson, E. J.; Lester, H. A.; Dougherty, D. A. J. Am. Chem. Soc.
2005 , 127 , 350-356.
URL: http://dx.doi.org/10.1021/ja0461771
4.
A fluorophore attached to nicotinic acetylcholine receptor β M2 detects agonist binding to the αδ site Dahan,
D. S.; Dibas, M. I. ; Petersson, E. J.; Auyeung, V. C.; Chanda, B.; Bezanilla, F.; Dougherty, D. A. Lester, H. A.
Proc. Natl. Acad. Sci. USA 2004 , 101 , 10195-10200.
URL: http://dx.doi.org/10.1073/pnas.0301885101
3.
A Perturbed pK a
at the Binding Site of the Nicotinic Acetylcholine Receptor: Implications for Nicotine
Binding Petersson, E. J.; Choi, A.; Dahan, D. S.; Lester, H. A.; Dougherty, D. A. J. Am. Chem. Soc.
2002 , 124 ,
12662-12663.
URL: http://dx.doi.org/10.1021/ja028206i
2.
MALDI-TOF mass spectrometry methods for evaluation of in vitro aminoacyl tRNA production Petersson, E.
J.; Shagholi, M.; Lester, H. A.; Dougherty, D. A. RNA 2002 , 8 , 542-547.
URL: http://dx.doi.org/10.1017/S1355838202026146
1.
Nonplanarity of Tetrafluorocyclobutadiene Petersson, E. J.; Fanuele, J. C.; Nimlos, M. R. Lemal, D. M.,
Ellison, G. B.; Radziszewski, J. G. J. Am. Chem. Soc.
1997 , 119 , 11122-11123.
URL: http://dx.doi.org/10.1021/ja971930u
Book Chapters and Invited Reviews: Independent (5 manuscripts, 3 citations)
6. Synthesis and Applications of Thioamide Containing Proteins Wang, Y. J.; Batjargal, S.; Petersson, E. J. Org.
Biomol. Chem. Invited review, in preparation.
5.
Transferase-Mediated Labeling of Protein N-Termini with Click Chemistry Handles Wagner, A. M.; Warner,
J. B.; Garrett, H. E.; Walters, C. R.; Petersson, E. J. Methods Mol. Biol.
Expected publication 2014 .
4. Two-for-One Designer Labels Petersson, E. J.; Warner, J.B. Nat. Chem. 2014 , 6 , 379-381.
URL: http://dx.doi.org/10.1038/nchem.1935
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E. James Petersson University of Pennsylvania
3. On the use of thioamides as fluorescence quenching probes for tracking protein folding and stability
Petersson, E. J.; Wissner, R. F.; Goldberg, J. M. Phys. Chem. Chem. Phys. 2014 , 16 , 6827-6837.
URL: http://dx.doi.org/10.1039/C3CP55525A
2. Minimalist Approaches to Protein Labeling: Getting the most fluorescent bang for your steric buck Speight, L.
C.; * Samanta, M.; * Petersson, E. J. Aust. J. Chem. 2014 , 67 , 687-700.
URL: http://dx.doi.org/10.1071/CH13554
Included in Aust. J. Chem . 2013 Physical Organic Chemistry Gordon Research Conference Issue.
Book Chapters and Invited Reviews: Graduate and Postdoctoral (1 manuscript, 21 citations)
1.
Caging Proteins through Unnatural Amino Acid Mutagenesis Petersson, E. J.; Brandt, G. S.; Zacharias, N.
M.; Dougherty, D. A.; Lester, H. A. Methods Enzymol.
2003 , 360 , 258-273.
URL: http://dx.doi.org/10.1016/S0076-6879(03)60114-X
Highlights of Independent Research
8. A Symposium in Honor of Peter B. Dervan, the 2014 ACS Chemical Biology Lectureship Award Winner
Soares, J. ACS Chem. Biol.
2014 , 9 , 1221-1223.
URL: http://dx.doi.org/10.1021/cb5003703
7. PROFILE: Early Excellence in Physical Organic Chemistry Petersson, E. J. J. Phys. Org. Chem.
2013 , 26 ,
869.
URL: http://dx.doi.org/10.1002/poc.3151
6. Chemical Protein Synthesis (CPS) Meeting 2013 Metanis, N. ChemBioChem 2013 , 14 , 1381-1384.
URL: http://dx.doi.org/10.1002/cbic.201300337
5. Tweaks Boost Protein Stability Arnaud, C. Chem. Eng. News 2012 , 90 , 68-71.
URL: http://cen.acs.org/articles/90/i36/Tweaks-Boost-Protein-Stability.html
4. Protein Motion Capture Drahl, C. Chem. Eng. News 2012 , 90 , 34.
URL: http://cen.acs.org/articles/90/i15/Protein-Motion-Capture.html
3. The Three Cornerstones of Chemical Biology: Innovative Probes, New Discoveries, and Enabling Tools
Thompson, A. D.; Makley, L. N.; McMenimen, K.; Gestwicki, J. E. ACS Chem. Biol . 2012 , 7 , 791-796.
URL: http://dx.doi.org/10.1021/cb3001827
2. Emerging Investigators 2012 Staff Chem. Commun. 2012 , 48 , 1350–1363.
URL: http://dx.doi.org/10.1039/c1cc90228h
1. Innovative Research at the Interface of Chemistry and Biology Soares, J. ACS Chem. Biol . 2011 , 6 , 521-522.
URL: http://dx.doi.org/10.1021/cb200157b
Patents
3.
Novel Thioamide-Modified Peptides and Uses Thereof Petersson, E. J.; Saghatelian, A. U.S. Provisional
Patent Application No. 61/985,045, filed April 28, 2014.
2.
One Step N-Terminal Tagging of Proteins Petersson, E. J.; U.S. Patent Application No. 61/659,559, filed
June 14, 2012.
1.
Novel Methods of Identifying Proteins Via N-Terminal Tagging and Selective Pull-Down Petersson, E. J.;
Noren C. U.S. Patent Application No. 61/659,562, filed June 14, 2012.
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E. James Petersson University of Pennsylvania
Recent and Upcoming Invited Presentations (of 75 total)
Syracuse University; Syracuse, NY Spring 2015
Johns Hopkins University; Baltimore, MD December 2014
Gettysburg College; Gettysburg, PA November 2014
University of Delaware; Newark, DE October 2014
Albert Einstein College of Medicine; Bronx, NY September 2014
Chemical Biology Summer School; Villars-sur-Ollon, Switzerland September 2014
Swiss Federal Institute of Technology (ETH); Zurich, Switzerland August 2014
University of Zurich; Zurich, Switzerland August 2014
Fluorescent Biomolecules and their Building Blocks (FB3) ; San Diego, CA August 2014
Yale University; New Haven, CT April 2014
American Chemical Society 2014 Chemical Biology Lectureship Symposium; Dallas, TX March 2014
University of California, San Diego; La Jolla, CA December 2013
University of Minnesota, Twin Cities; Minneapolis, MN November 2013
University of California, Berkeley; Berkeley, CA November 2013
Stanford University; Palo Alto, CA November 2013
University of California, San Francisco; San Francisco, CA November 2013
University of Rochester; Rochester, NY October 2013
University of Illinois, Urbana-Champaign; Urbana, IL October 2013
California Institute of Technology; Pasadena, CA October 2013
The Ohio State University; Columbus, OH October 2013
University of Wisconsin, Madison; Madison, WI October 2013
Temple University; Philadelphia, PA September 2013
Columbia University; New York, NY September 2013
Swarthmore College; Swarthmore, PA September 2013
American Chemical Society Fall 2013 Young Investigator Symposium; Indianapolis, IN September 2013
European Symposium on Organic Chemistry Young Investigator Workshop; Marseilles, France July 2013
Physical Organic Chemistry Gordon Conference; Holderness, NH June 2013
Japanese Chemical Biology Society 8 th Annual Meeting; Tokyo, Japan June 2013
Chemical Protein Synthesis Meeting; Vienna, Austria April 2013
University of Pittsburgh; Pittsburgh, PA March 2013
University of Michigan; Ann Arbor, MI February 2013
Wayne State University; Detroit, MI February 2013
Tufts University; Medford, MA January 2013
University of California, Los Angeles; Los Angeles, CA November 2012
University of California, Irvine; Irvine, CA October 2012
Colorado State University; Fort Collins, CO October 2012
Dartmouth College; Hanover, NH September 2012
New York University; New York, NY September 2012
St. Mary’s College, Philadelphia; MD August 2012
Fluorescent Biomolecules and their Building Blocks (FB3) ; Göteborg, Sweden July 2012
Stony Brook University (SUNY), Stony Brook; NY April 2012
University of Colorado, Boulder; CO October 2011
New England Biolabs, Ipswich; MA September 2011
Lehigh University, Bethlehem; PA September 2011
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E. James Petersson University of Pennsylvania
Research Funding
Pending Support
NIH R01
“Targeting LexA to Combat Antibiotic Resistance”
Kohli (PI)/Petersson (Co-Invest.) 04/2015 – 04/2020
Development of fluorescent assays and application to deciphering LexA activation mechanism.
Total costs: $1,900,030 ($323,040 to EJP)
UPenn URF Petersson/Schelter (Co-PI) 07/2014 – 06/2015
“Preparing Tomorrow’s PIs”
Training program including research proposal and undergraduate mentorship experiences for graduate students.
Total costs: $50,000
NIH R21 (EB019699-01) Petersson/Saghatelian (Co-PI)
“Thioamide Substituted Incretins with Increased Stability and High Potency”
In vitro and in vivo tests of thioamide-modified dietary hormones.
Total costs: $469,737 ($232,237 to EJP)
10/2014 – 10/2016
Current Support
NSF MRI (CHE-1337449) Petersson/Baumgart (Co-PI) 10/2013 – 10/2016
“MRI: Acquisition of Autosampling Stopped-Flow Spectrometer for in vitro Kinetic Characterization of
Biomolecule Binding and Enzymatic Activity”
Instrument grant to obtain stopped-flow fluorometer for Biological Chemistry Resource Center.
Total costs: $157,500 (includes $47,250 cost share)
NIH R01 (NS081033) Petersson (PI)
“Semi-synthetic α -Synuclein for Tracking Aggregation and Cell-to-Cell Transmission”
10/2012 – 07/2016
Application of fluorescent protein folding probes to the study of α -synuclein oligomers and fibrils in vitro and in cultured cells.
Total costs: $1,354,049
NSF CAREER Award (CHE-1150351) Petersson (PI)
“CAREER: Thioamides as Minimalist Chromophores to Monitor Protein Dynamics”
07/2012 – 06/2017
Study of photophysical properties of sulfur analogs of peptide bonds and their impact on protein folding.
Total costs: $575,000
Completed Support
Sloan Research Fellowship (BR2012-085) Petersson (PI)
“Toward Single Amino Acid Resolution Protein Folding Studies”
Development of in vitro and in vivo fluorescent protein labeling methods.
Total costs: $50,000
Searle Scholar Award (10-SSP-214) Petersson (PI)
“New Methods for Probing and Controlling Dynamic Proteins”
General methods for ribosomal incorporation of synthetic modifications into proteins.
Total costs: $300,000
09/2012 – 08/2014
07/2010 – 07/2014
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E. James Petersson University of Pennsylvania
UPenn Institute on Aging Petersson (PI) 07/2012 – 06/2013
“Using Semi-synthetic Proteins to Understand the Formation and Propagation of Lewy Bodies in Parkinson's
Disease and Dementia”
Application of fluorescent protein folding probes to the study of amyloid formation.
Total costs: $50,000
NSF EAGER Grant (CHE-1020205) Petersson (PI)
“Backbone Selenoamides as Minimal Chromophores to Monitor Protein Dynamics”
07/2010 – 06/2012
Study of photophysical properties of sulfur and selenium analogs of peptide bonds and chemical ligations for incorporating them into proteins.
Total costs: $275,000
UPenn TAPITMAT (Biomedical Imaging) Petersson (PI)
“Voltage-Sensitive Quantum Dots for High Resolution Imaging of Neuronal Activity”
02/2010 – 02/2011
Cell-surface fluorophores that respond to changes in membrane voltage to monitor nerve cell excitability.
Total costs: $50,000
UPenn URF Petersson (PI) 02/2010 – 02/2011
“Voltage-Sensitive Quantum Dots for High Resolution Imaging of Neuronal Activity”
Cell-surface fluorophores that respond to changes in membrane voltage to monitor nerve cell excitability.
Total costs: $50,000
Researchers Supervised
Undergraduate Nicholas P. Marotta (University of Pennsylvania, B.S. 2010)
Currently: University of Southern California Biochemistry Graduate Program
Christina L. J. Grindley (University of Pennsylvania, B.S. 2011)
Currently: Oliver Wyman Consulting
Eileen M. Moison (University of Pennsylvania, B.S. 2012)
Currently: Harvard University Chemical Biology Graduate Program
Alyssa M. Klein (Harvard University, Class of 2013)
Currently: Research Assistant, Fox Chase Cancer Center
Colin M. Fadzen (University of Pennsylvania, B.S./M.S. 2013)
Currently: Harvard University/Massachusetts Institute of Technology M.S.T.P. Program
Haviva E. Garrett (University of Pennsylvania, B.S. 2013)
Currently: Research Assistant, Xiangpeng Kong, New York University Medical Center
Anand Muthusamy (University of Pennsylvania, Class of 2014)
Currently: Research Assistant, Luke Lavis, HHMI Janelia Farm Campus
Benson S. Chen (University of Pennsylvania, Class of 2016)
Graduate Mark W. Fegley (University of Pennsylvania, M.S. 2011)
Currently: Temple St. Luke's Medical School
Jacob M. Goldberg (University of Pennsylvania, Ph.D. 2013)
Currently: Postdoctoral Scholar, Stephen Lippard, Massachusetts Institute of Technology
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E. James Petersson University of Pennsylvania
Anne M. Wagner (University of Pennsylvania, Ph.D. 2013)
Currently: Senior Scientist, L’Oreal Inc.
Lee C. Speight (University of Pennsylvania, Ph.D. 2014)
Currently: Development Analyst, Green Biologics, Inc.
John B. Warner (University of Pennsylvania, Ph.D. 2014)
Currently: Postdoctoral Scholar, Hillel Lashuel, École Polytech. Fédérale de Lausanne
Solongo Batjargal (University of Pennsylvania, Ph.D. 2014)
Postdoctoral Tomohiro Tanaka (Tokyo Medical and Dental University, Ph.D. 2011)
Currently: Research Associate, Shin Aoki, Tokyo University of Science
Moumita Samanta (Indian Institute of Science, Ph.D. 2011)
Currently: Lecturer, Liberal and Professional Studies Program, University of Pennsylvania
Current Research Group
Undergraduate E. Keith Keenan (University of Pennsylvania, Class of 2015)
Lily Owei (University of Pennsylvania, Class of 2016)
Eileen Hoang (Swarthmore College, Class of 2016)
Graduate Rebecca F. Wissner (New York University, B.S. 2009)
Yanxin Wang (Hong Kong University of Science and Technology, B.S. 2010)
Christopher R. Walters (University of Michigan, B.S. 2012)
Xing Chen (Peking University, B.S. 2012)
John J. Ferrie (The College of New Jersey, B.S. 2013)
Itthipol Sungwienwong (Mahidol University, B.S. 2013)
Daniel Miklos Szantai-Kis (Karlsruher Institut fur Technologie, Dipl.-Chem. 2012)
Yun Huang (Max Planck Institute, Ph.D. 2012) Postdoctoral
Conor M. Haney (University of Pittsburgh, Ph.D. 2014)
Selected Awards and Fellowships to Laboratory Personnel
Undergraduate Dean’s Scholar (top 0.3% of graduating class) – Eileen Moison, 2012; Colin Fadzen, 2013
Gates Scholarship - Eileen Moison, 2012
Vagelos Science Challenge Award - Colin Fadzen, 2012
NSF REU Fellowships – Alyssa Klein 2010, Keith Keenan 2013
Graduate Dean’s Scholar (top 0.3% of graduating class) – Jacob Goldberg, 2013
Excellence in Chemistry Research Award - Jacob Goldberg, 2012; Rebecca Wissner, 2013
Miller Award (Most Outstanding Chemistry Dissertation) - Jacob Goldberg, 2014
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E. James Petersson University of Pennsylvania
Penn Prize (University Teaching Award) - Jacob Goldberg, 2010; Mark Fegley, 2011
Departmental Outstanding Teaching Assistant Award – John Warner, 2009; Rebecca
Wissner, 2010; Solongo Batjargal, 2012; Lee Speight, 2013; Christopher Walters, 2014
Protein Society Outstanding Poster Prize – Rebecca Wissner and Solongo Batjargal, 2011
Dissertation Completion Fellowship - Jacob Goldberg, 2013; Rebecca Wissner, 2014
Douty Fellowship – Yanxin Wang, 2014
Chemistry-Biology Interface Training Grant Fellowship - Rebecca Wissner, 2010
Structural and Molecular Biology Training Grant Fellowship – Christopher Walters, 2014
Parkinson’s Disease Foundation Fellowship – Solongo Batjargal, 2013
Royal Thai Fellowship - Itthipol Sungwienwong, 2014
National Science Foundation Graduate Research Fellowship - John J. Ferrie, 2014
Postdoctoral Japan Society for Promotion of Science Fellowship – Tomohiro Tanaka, 2012
Teaching Experience
Chemistry 243-001: Organic Chemistry II: Applications in Chemical Biology (with Chenoweth) Spring 2014
Chemistry 700-401: Chemical Biology Spring 2014
Chemistry 243-001: Organic Chemistry II: Applications in Chemical Biology (with Chenoweth) Spring 2013
Chemistry 700-401: Chemical Biology Spring 2013
Chemistry 251-001: Principles of Biological Chemistry
Chemistry 700-401: Chemical Biology
Chemistry 601: Tutorial in Chemical Biology
Chemistry 251-001: Principles of Biological Chemistry (with Saven)
Spring 2012
Spring 2012
Fall 2011
Spring 2011
Chemistry 700-001: Chemical Biology
Chemistry 251-601: Principles of Biological Chemistry (LPS)
Chemistry 251-001: Principles of Biological Chemistry
Chemistry 700-001: Chemical Biology
Chemistry 557: Mechanisms of Biological Catalysis (with Christianson)
Chemistry 251-001: Principles of Biological Chemistry (with Saven)
Teaching Reviews (out of 4.0)
Spring 2011
Spring 2010
Spring 2010
Fall 2010
Spring 2009
Spring 2009
Chemistry 243:
Instructor Quality
Spring 2014 – 2.12
Average – 2.48
Amount Learned in Course
Spring 2014 – 2.91
Average – 2.75
Course Quality
Spring 2014 – 1.88
Average –2.78
Chemistry 251: Spring 2012 – 2.72
Average – 2.55
Spring 2012 – 2.51
Average – 2.50
Spring 2012 – 2.40
Average – 2.28
Chemistry 700: Spring 2013 – 3.83 Spring 2013 – 4.00 Spring 2013 – 3.50
Average – 3.65 Average – 3.73 Average – 3.58
Nominated for Jane Glick Award for outstanding contributions to biomedical graduate education in 2013.
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E. James Petersson University of Pennsylvania
Departmental and University Service
Biomedical Graduate Studies Student Awards Committee
Structural and Molecular Biology Training Grant Trainer
Chemistry Future Faculty Trainer
Biological Chemistry Resource Center Faculty Director
Chemistry Biology Interface Training Grant Committee
Chemistry Instrumentation Committee
Search Committee for Bioorganic Junior Faculty Hire
Chemistry Graduate Admissions Committee
Chemistry Graduate Committee
Masters Degree Thesis Committees (11)
Yoonjoo Kim, Chemistry, M.S. 2009 – Jeffrey Bode
Sumeet Khetarpal, Chemistry, M.S. 2010 – Daniel Rader
Maggie He, Chemistry, M.S. 2010 – Jeffrey Bode
Yi-Lin Huang, Chemistry, M.S. 2010 – Jeffrey Bode
Arthur Argall, Chemistry, M.S. 2011 – Claire Mitchell
Min Pan, Chemistry, M.S. 20111 – Ronen Marmorstein
Le Wang, Chemistry, M.S. 2012 – Lawrence Brass
Nabil Darwich, Chemistry, M.S. 2013 – Virginia Lee
Henry Wang, Chemistry, M.S. 2013 – Jim Shorter
Jeffrey Yeh, Chemistry, M.S. 2013 – Virginia Lee
Alex Genshaft, M.S. 2014 – David Christianson
Doctoral Degree Thesis Committees (30)
P. Aru Hill, Chemistry, Ph.D. 2009 – Ivan Dmochowski
Jun Wang, Chemistry, Ph.D. 2010 – Bill DeGrado
Irene Medina, Chemistry, Ph.D. 2011 – Jeffrey Bode
Patrick Lombardi, Chemistry, Ph.D. 2011 – David Christianson
Christopher Lanci, Chemistry, Ph.D. 2012 – Jeffery Saven
Xiaojing Liu, Chemistry, Ph.D. 2012 – Ian Blair
Brittani Ruble, Chemistry, Ph.D. 2012 – Ivan Dmochowski
Ying-Ling Chiang, Chemistry, Ph.D. 2013 – Jeffrey Bode
Glen Liszczak, Chemistry, Ph.D. 2013 – Ronen Marmorstein
Wei Liu, Chemistry, Ph.D. 2013 – Barry Cooperman
Kathryn Smith, Biochemistry and Molecular Biophysics, Ph.D. 2013 – Feng Gai
2008 –
Nataline Meinhardt, Biochemistry and Molecular Biophysics, Ph.D. 2014 – Doron Greenbaum
Christopher Bryan, Chemistry (withdrawn) – Emmanuel Skordalakes
Daniel Emerson, Chemistry (withdrawn) – Ivan Dmochowski
Stephanie Barros, Chemistry – David Chenoweth
Steve Brown, Chemistry – Amos Smith
Matthew Eibling, Chemistry – Jeffery Saven
Golda Harris, Chemistry – David Christianson
Kelly Karch, Biochemistry and Molecular Biophysics – Benjamin Garcia
Roy Malakamal, Chemistry – David Chenoweth
Mark Mason, Chemistry – Emmanuel Skordalakes
Cheryl McCullough, Chemistry – Ronen Marmorstein
Charlie Mo, Biochemistry and Molecular Biophysics – Rahul Kohli
Brittany Riggle, Chemistry – Ivan Dmochowski
2013 –
2013 –
2012 –
2012 –
2011 –
2009 –
2009 – 2010
2008 –
2008 – 2009
2008 –
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E. James Petersson University of Pennsylvania
Rong Shen, Chemistry – Barry Cooperman
Mai Tran, Chemistry – David Chenoweth
Scott Ugras, Biochemistry and Molecular Biophysics – Harry Ischiropoulos
Christopher Von Bargen, Chemistry – Jeffery Saven
Zhenyu Zhao, Biochemistry and Molecular Biophysics – Les Dutton
Yitao Zhang, Chemistry – David Chenoweth
Extramural Service
Manuscript Peer Review
ACS Synthetic Biology
ACS Chemical Biology
ACS Medicinal Chemistry Letters
Amino Acids
Angewandte Chemie
Chemical Science
Chemistry: A European Journal
Journal of Organic Chemistry
Bioorganic and Medicinal Chemistry Letters
Biophysical Journal
ChemBioChem
Chemical Communications
Grant Application Peer Review
Alzheimer’s Association Ad Hoc Grant Reviewer
ETH Zurich Research Foundation Ad Hoc Grant Reviewer
Macromolecules
Molecular Biosystems
Nature Chemistry
Nature Chemical Biology
Organic Letters
Journal of the American Chemical Society
National Science Foundation Panel Participant and Ad Hoc Grant Reviewer
Research Corporation for Scientific Advancement Ad Hoc Grant Reviewer
Swiss National Science Foundation Ad Hoc Grant Reviewer
Meeting Organization
244 th American Chemical Society National Meeting Symposium Organizer
5 th Annual Frontiers at the Chemistry Biology Interface Symposium Chief Symposium Organizer
6 th Annual Frontiers at the Chemistry Biology Interface Symposium Organizing Committee
7 th Annual Frontiers at the Chemistry Biology Interface Symposium Organizing Committee
Advisory Committees
National Academy of Sciences Convergence Workshop Young Faculty Participant
American Chemical Society Biological Division Advisory Committee Council Member
New York Academy of Sciences Chemical Biology Steering Group
American Chemical Society National Award Selection Committee Member
Educational Outreach
UPenn Open Lab Days On-campus demonstrations
Cedarbrook Middle School; Cheltenham, PA Classroom visits
Science Café Lecturer
EJPLab YouTube Site www.youtube.com/user/ejplab/ (>25,000 views) Educational videos and tools
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