Curriiculum Vitaee Tanis Hogg, Dr. rer. n
nat. Assistant Academic De
ean for Mediccal Education
nd Vice Chair, Department of Medical E ducation Associate Professor an
essor, Departtment of Biom
medical Sciencces Clinical Asssociate Profe
Paul L. Foster School of Medicine Texas Tecch University Health Sciencces Center El Paso, TX Office add
dress: Departme
ent of Medicaal Education Medical EEducation Building – Suite 2200‐E Paul L. Foster School of Medicine 5001 El Paaso Drive El Paso, TX 79905 one: (915) 215‐4340 Office pho
Office fax: (915) 783‐1715 Cell phone: (915) 504‐9
9597 uhsc.edu E‐mail: tanis.hogg@ttu
EDUCATIO
ON: 1993 Bachelor of Sciencce Biochemisstry 2001 Dr. re
er. nat. (Ph.D..) Magn
na cum laudee Biochemisstry and Biophysicss h University of British
mbia, Vancouvver, Colum
Canad
da Friedrrich‐Schiller University of Jena, Germaany Page 1
1 of 21 ACADEMIC AND PROFESSIONAL EXPERIENCE: 05/01‐04/02 05/02‐03/04 04/04‐12/07 01/08‐present 10/13‐present 02/14‐present Post‐Doctoral Research Associate Department of Structural Biology and Crystallography, Institute of Molecular Biotechnology, Jena, Germany JenaDrugDiscovery GmbH, Jena, Germany Founding Director of Pharmaceutical Research and Development Research Group Leader and Institute of Biochemistry, Center for Structural and Senior Lecturer Cell Biology in Medicine, University of Lübeck, Germany Associate Professor Department of Medical Education, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX Associate Professor Graduate School of Biomedical Sciences Texas Tech University Health Sciences Center El Paso, TX Clinical Associate Professor Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX EDUCATIONAL FACULTY DEVELOPMENT: 2009 PLFSOM Faculty Development Course VII 2010 IAMSE Faculty Development Workshop: How To Become an Effective Course Director Harvard Macy Program for Educators in Health Professions Harvard Macy Program: A Systems Approach to Assessment in Health Professions Education 2010‐2011 2014 El Paso, TX New Orleans, LA Harvard University, Cambridge, MA Harvard University, Cambridge, MA Page 2 of 21 UNIVERSITY TEACHING EXPERIENCE: Local 04/98‐04/02 Macromolecular Crystallography 1st year graduate students 04/04‐12/07 Biochemistry I/II 2nd year undergraduate students 04/04‐12/07 Biochemistry Practicum 2nd year undergraduate students 04/04‐12/07 Medical Biochemistry Seminar 1st year medical students 05/05‐12/07 Drug Design 1st year graduate students 08/09‐present Scientific Principles of Medicine 1st and 2nd year medical students 09/09‐present PLFSOM Faculty Development Course TTUHSC El Paso Faculty PLFSOM Community Faculty Development Program TTUHSC El Paso Faculty Introduction to Biomedical Studies 1st year graduate students 10/10‐10/11 02/13‐05/14 09/13‐present Regional 05/12‐present Biochemistry 1st year graduate students Biochemistry and Cell Biology Senior pre‐med students National/International 03/04 Macromolecular Crystallization Course Institute of Molecular Biotechnology, Friedrich‐Schiller University of Jena, Germany
24 hours per academic year University of Lübeck, Germany 36 hours per academic year University of Lübeck, Germany 16 hours per academic year University of Lübeck, Germany 24 hours per academic year University of Lübeck, Germany 18 hours per academic year Paul L. Foster School of Medicine 130 hours per academic year Paul L. Foster School of Medicine 5 hours per academic year Paul L. Foster School of Medicine 1 hour per academic year TTUHSC – Graduate School of Biomed. Sci. 2 hours per academic year TTUHSC – Graduate School of Biomed. Sci. 10 hours per academic year Texas Joint Admission Medical Program Summer II Enrichment Course (PLFSOM) 17 hours per academic year 21st Annual Meeting of the German Crystallographic Society (DGK) Page 3 of 21 Doctoral students, post‐docs, independent scientists 08/06 Macromolecular Crystallization Course Doctoral students, post‐docs, independent scientists 10/09‐present PLFSOM Curriculum Overview In‐state and out‐of‐state pre‐med candidates for admission Jena, Germany 8 hours per course 11th International Conference for the Crystallization of Biological Macromolecules (ICCBM‐11) Quebec City, Canada 10 hours per course PLFSOM Office of Admissions 10 hours per academic year MENTORING EXPERIENCE: 03/03‐04/04 Master’s thesis project mentor 2nd year graduate students 06/04‐12/07 Bachelor’s thesis project mentor 3rd year undergraduate students 09/04‐12/07 Doctoral thesis project mentor PhD students 06/05‐12/07 Master’s thesis project mentor 2nd year graduate students 05/12‐present Scholarly activity and research project (SARP) mentor 2nd ,3rd and 4th year medical students M.S. project mentor 2nd year graduate students 05/14‐present JenaDrugDiscovery GmbH, in affiliation with Friedrich‐Schiller University of Jena Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany Department of Medical Education, Laboratory for Education in Molecular Medicine, Paul L. Foster School of Medicine Graduate School of Biomedical Sciences, Paul L. Foster School of Medicine RESEARCH GRANTS: 04/05‐03/08 The bacterial stringent response: the role of RelA and related proteins in modulating the critical balance between proliferation and survival. German‐Israeli Foundation for Scientific Research and Development (GIF) 835/2004 Co‐investigator (€399,600 over 3 years) (PI: Prof. Dr. Rolf Hilgenfeld) The major goal of this study was to rationally design novel antibiotics targeting the bacterial stringent response by using a combination of computational chemistry, medicinal chemistry, and X‐ray crystallography. Page 4 of 21 03/06‐02/08 01/08‐12/13 01/08‐12/12 06/14‐present Intracellular feeding of Plasmodium parasites: Characterization and inhibition of the interaction between falcipain‐2 and hemoglobin. German Research Foundation (DFG) Priority Program ‘Life Inside Cells’ (SPP 1131) Co‐investigator (€105,000 over 2 years) (PI: Prof. Dr. Rolf Hilgenfeld) The major goal of this study was to elucidate the 3D structures and binding constants of the malarial protease falcipain‐2 in complex with its hemoglobin substrate to facilitate rational synthesis of novel antimalarial compounds. Autoimmunity to type VII collagen: From genetic susceptibility to novel therapeutic strategies. German Research Foundation (DFG) Excellence Cluster ‘Inflammation at Interfaces’ (EXC 306) Co‐investigator (€3.6 million over 6 years) (PI: Prof. Dr. Detlef Zillikens) The goals of this integrated and multi‐institutional study were to: (i) Elucidate susceptibility genes for blister induction by autoantibodies against type VII collagen and other cell‐matrix adhesion molecules; (ii) Determine the crystal structure of type VII collagen and its antibody‐binding sites at atomic resolution; (iii) Characterize inflammatory pathways triggered by autoantibodies resulting in loss of cell‐matrix adhesion and epithelial stem cell deletion; and (iv) Identify and therapeutically target T and B cell‐dependent mechanisms required for production of pathogenic autoantibodies against type VII collagen. *Note: I was recruited to TTUHSC‐PLFSOM prior to commencement of funding. Structural analysis of virulence‐associated proteins of Chlamydiae. German Research Foundation (DFG) Excellence Cluster ‘Inflammation at Interfaces’ (EXC 306) Principle investigator (€830,000 over 5 years) The major goal of this study was to take a structural proteomics approach to surveying the 3D structures of virulence‐associated chlamydial proteins, to use this information to predict and verify the biological function of these proteins, and to initiate structure‐based drug design strategies. *Note: I was recruited to TTUHSC‐
PLFSOM prior to commencement of funding. Structural and functional characterization of an inactive EF‐Tu mutant. TTUHSC‐PLFSOM Scholarly Activity and Research Project (SARP) Mini‐Grant Principle Investigator ($4,000 over 1 year) The focus of this study is to shed light on the structural and functional roles of conserved catalytic residues of elongation factor Tu (EF‐Tu), a key protein involved in bacterial protein biosynthesis and an important antibacterial drug target. Page 5 of 21 MAJOR ADMINISTRATIVE LEADERSHIP POSITIONS: Local 05/02‐03/04 04/04‐12/07 04/04‐04/05 04/04‐12/07 05/05‐12/07 02/08‐09/08 08/08‐06/10 Founding Director of Pharmaceutical Research and Development Research Group Leader Molecular basis of bacterial and protozoal infections Unit Director Course: X‐ray Crystallography Unit Director Course: Proteins Founding Course Director Course: Drug Design Unit Director Course: Scientific Principles of Medicine Unit: GI/Heme Founding Course Director Course: Scientific Principles of Medicine Year 2 (SPM III/IV) 08/08‐present Founding Course Director Course: Scientific Principles of Medicine Year 1 (SPM I/II) 08/08‐present Vice‐Chair Department of Medical Education 03/10‐present Test Construction Coordinator National Board of Medical Examiners (NBME) 07/10‐present Course Co‐director Course: Scientific Principles of Medicine Year 2 (SPM III/IV) Chair 08/10‐06/12 JenaDrugDiscovery GmbH, Jena, Germany Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Germany University of Lübeck, Germany University of Lübeck, Germany University of Lübeck, Germany Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech Page 6 of 21 Medical Educator Search Committee 12/10‐10/12 12/10‐10/12 05/11‐05/12 09/11‐present 10/12 11/12 09/14‐present Regional 05/11‐present 05/11‐present PLFSOM Leadership Team Member – LCME Accreditation Survey: Education Program, Program Design, Implementation, Evaluation and Management PLFSOM Leadership Team Member – LCME Accreditation Survey: Required Courses and Clerkships Unit Director Course: Scientific Principles of Medicine Unit: Introduction to Health and Disease University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Paul L. Foster School of Medicine, Texas Tech Co‐Director University Health Sciences Center, El Paso, Department of Biomedical Sciences Texas X‐ray Microanalysis Facility PLFSOM Leadership Team Member – Paul L. Foster School of Medicine, Texas Tech LCME Accreditation Survey: Graduate University Health Sciences Center, El Paso, Programs, Basic Science and Texas Clinical/Translational Research Paul L. Foster School of Medicine, Texas Tech Ad hoc Leadership Team Member – University Health Sciences Center, El Paso, Society for Simulation in Healthcare Council for Accreditation Survey: Texas Review of PLFSOM Curricula Assistant Academic Dean for Medical Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Education Texas Founding Course Director Course: Texas Joint Admission Medical Program (JAMP) Summer II Enrichment Course Alternate Council Representative Texas Joint Admission Medical Program (JAMP) Council Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas Joint Admission Medical Program Austin, TX Page 7 of 21 National/International 04/04‐09/04 Chief Organizer and Conference Program Chair 04/10 PLFSOM Leadership Team: Curriculum Consultant 05/10 08/10‐08/12 12/10 01/12 03/12 03/12 03/12‐08/12 05/11‐present 02/11‐05/11 PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant Executive Committee Member Conference Planning Committee Member 05/11‐05/13 Conference Organization Committee Member and Program Co‐chair 06/12‐11/12 Conference Organization Committee Member and Program Co‐chair 05/13‐present Conference Organization Committee Member and Program Co‐chair 1st Baltic Sea Biocrystallography Meeting, Travemünde, Germany Fu‐Jen Catholic University School of Medicine, Taiwan I‐Shou University College of Medicine, Taiwan University of Oklahoma‐Tulsa School of Medicine AAMC Senior Director for Educational Affairs, Brownell Anderson California Northstate University College of Medicine Georgetown University School of Medicine ATSU College of Osteopathic Medicine Central Michigan University College of Medicine International Association of Biochemistry Course Directors (ABCD) AAMC New and Developing Medical Schools Consortium Meeting El Paso, TX 4th International Conference of the Association of Biochemistry Course Directors Santa Fe, NM TTUHSC and the Dartmouth Institute: A Healthcare Dialogue on the Border El Paso, TX 5th International Conference of the Association of Biochemistry Course Directors Santa Fe, NM Page 8 of 21 06/13 04/14 PLFSOM Leadership Team: Curriculum Consultant PLFSOM Leadership Team: Curriculum Consultant The Dell Medical School at UT Austin California University of Science and Medicine (Cal Med) and California Northstate University College of Medicine PROFESSIONAL SOCIETIES: 1996‐2007 German Crystallographic Association (DGK) 1996‐present International Union of Crystallography (IUCr) 2001‐2007 European Crystallographic Association (ECA) 2008‐present American Crystallographic Association (ACA) 2008‐present International Association of Medical Science Educators (IAMSE) 2009‐present Association of Biochemistry Course Directors (ABCD) 2011‐present Association of Biochemistry Course Directors Executive Committee (ABCDEx) Member (non‐elected) Member (non‐elected) Member (non‐elected) Member (non‐elected) Member (non‐elected) Member (non‐elected) Member (elected) EDITORIAL ACTIVITIES: 2004‐2008 Ad hoc Reviewer 2004‐2008 Ad hoc Reviewer 2007‐present Ad hoc Reviewer 2008‐present Biochemistry Assessment Item Author, Case Reviewer and Content Consultant 2012‐present Ad hoc Reviewer 2013‐present Ad hoc Reviewer Journal of Molecular Biology FEBS Letters Acta Crystallographica Section D Elsevier BMC Medical Education MedEdPORTAL Page 9 of 21 GRANT REVIEW ACTIVITIES: 2011 Ad hoc Reviewer Einstein Foundation Berlin AWARDS AND HONORS: 1986 1986 1989 2001 2004 2006 2007 2009 2009 2010 2011 2012 2012 2013 Kevin Lapa Scholarship (Kevin Lapa Scholarship Society) Royal Canadian Legion Scholarship Thompson Rivers University Faculty of Science Scholarship Magna cum laude, Doctoral Dissertation, Friedrich‐Schiller University Editors’ Choice for Biochemistry Research, Science Magazine, Science 304 Front Cover Feature Illustration, Journal of Biological Chemistry 281 (35) Heinrich‐Dräger Prize for Infectious Disease Research TTUHSC PLFSOM Faculty Development Course VII Valedictorian TTUHSC PLFSOM Faculty of the Year Nominee TTUHSC PLFSOM Faculty of the Year Award Presenter Harvard‐Macy Scholar in Medical Education TTUHSC PLFSOM Faculty of the Year Nominee Master of Ceremonies, Annual PLFSOM Faculty Recognition Awards and Banquet TTUHSC PLFSOM Faculty of the Year Nominee COMMITTEE SERVICE: Local 01/08‐05/14 01/08‐09/08 PLFSOM Department of Medical Education Basic Science Medical Educator Search Committee TTUHSC El Paso Science Luncheon Member Organizer and Chair Page 10 of 21 05/08‐08/08 PLFSOM Year3‐4 Medical Curriculum Task Force 05/08‐05/14 PLFSOM Department of Medical Education Clinician Medical Educator Search Committee PLFSOM Department of Medical Education College Master Search Committee PLFSOM Biomedical Research Core Facility Scientific Advisory Group Biomedical Research Core Facility Director Search Committee PLFSOM Graduate School Planning Group 05/08‐12/11 07/08‐06/09 07/08‐09/12 07/08‐06/09 07/08‐present 08/08‐present 09/08‐present 12/08‐12/10 PLFSOM Office of Admissions Candidate Interviewer Panel PLFSOM Course Directors Committee PLFSOM Curriculum and Educational Policy Committee (CEPC) PLFSOM Ad hoc Committee for Tenure and Promotion Criteria 01/09‐12/10 PLFSOM Grading and Remediation Task Force 02/09‐06/09 Howard Hughes Medical Institute ‘Med into Grad’ Grant Application Task Force 06/09‐present PLFSOM Student Scholarly Activity and Research Project Oversight Committee PLFSOM Laboratory for Education in Molecular Medicine (LEMM) Strategic Planning Committee PLFSOM Director of Assessment and Evaluation Search Committee PLFSOM Cancer Center of Excellence Planning Committee Scientific Principles of Medicine Course Committee PLFSOM LCME Subcommittee on Educational Objectives and Content Standards 07/09‐present 07/09‐03/10 01/08‐09/08 08/08‐present 09/09‐12/09 Member Member Member Member Member Member Member Member Member Member Member Member Member Member Member Member Chair Member Page 11 of 21 01/10‐12/10 Chair of Pediatrics Search Committee 03/10‐06/10 Associate Dean of Clinical Affairs Search Committee 05/10‐12/12 Biomedical Research Scientist Search Committee 06/10‐12/11 PLFSOM Professionalism Committee 06/10 PLFSOM Student and Community Enrichment Program LCME Subcommittee on Required Courses and Clerkships 07/10‐present 07/10‐present 08/10‐03/11 LCME Subcommittee on Educational Objectives and Curriculum Structure PLFSOM Ad hoc Committee for Faculty Evaluations 08/10‐12/12 PLFSOM Educational Program Strategic Task Force 09/10‐present PLFSOM Research Committee 03/11‐12/12 PLFSOM Student Assessment Task Force PLFSOM Medical Education IT and IT Security Consultant Group PLFSOM Post‐Baccalaureate and Joint Admissions Medical Program (JAMP) Committee PLFSOM Histopathology Core Facility Committee 06/11‐present 06/11‐present 01/12‐present 06/12‐12/12 PLFSOM Ad hoc Committee For New Faculty Tracks 02/13‐03/13 Chair of Internal Medicine Search Committee 04/13 7th Annual TTUHSC‐PLFSOM Research Colloquium Poster Judging Panel Candidate Consultant: Curriculum and Educational Facilities Candidate Consultant: Curriculum and Educational Facilities Ad hoc Interviewer and Candidate Consultant: Educational Facilities Member Mock Interviewer Member Member Member Member Member Member Member Member Member and Co‐director pro tem Member Candidate Consultant: Curriculum and Educational Facilities Member Page 12 of 21 05/13‐present 06/‐13‐07/13 05/13‐present 11/13‐12/13 11/13‐12/13 11/13‐01/14 03/14‐04/14 11/13‐05/14 04/14 01/15‐present Regional 11/11‐present PLFSOM Curriculum Management System (Ilios/NemiSYS) Steering Committee PLFSOM Histopathology Core Facility Lab Manager Search Committee AAMC Medical Academic Performance Services (MedAPS) and MedBiquitous Curriculum Inventory: PLFSOM Transition and Compliance Group Chair of Anesthesiology Search Committee Member Member Member Candidate Consultant: Curriculum and Educational Facilities Director of Institutional Planning and Effectiveness Search Candidate Consultant: Curriculum and Committee Educational Facilities Member Society, Community and the Individual Course Director Search Committee Associate Dean of Research Search Committee Candidate Consultant: Curriculum and Educational Facilities Department of Medical Education Curriculum Retreat and Co‐organizer and Workshop Program Co‐Chair 8th Annual TTUHSC‐PLFSOM Research Colloquium Poster Member Judging Panel Director of the Center of Excellence for Diabetes and Member Obesity Search Committee Texas Joint Admissions Medical Program (JAMP) Council Alternate Representative National/International 04/08 US/Mexico Infectious Disease Forum Steering Committee Member 11/10‐02/11 Faculty Tenure and Promotion Committee, Sultan Qaboos External Reviewer University, College of Medicine and Health Sciences, Sultanate of Oman 04/11‐present International Association of Biochemistry Course Member Page 13 of 21 10/13 Directors Executive Committee (ABCDEx) National Board of Medical Examiners (NBME) Customized Member Assessment Services Program Focus Group ORAL PRESENTATIONS: 05/97 12/97 02/98 10/98 10/98 02/99 09/99 07/03 11/04 10/05 10/06 Protein‐protein interactions in EF‐Tu*GDP crystals. Joint Annual Meeting: Human Capital and Mobility Network on Molecular Mechanisms of Initiation of Prokaryotic Translation & Human Capital and Mobility Network on Molecular Mechanisms of Elongation Factor Tu, Spetses, Greece. Biological role and structural consequences of proteolytic cleavage of bacterial elongation factor Tu. Protease Symposium, Dornburg Castle, Germany. Structures of Thermus thermophilus elongation factor Tu mutants lacking conserved histidine residues. 3rd Colloquium of the German Research Foundation Priority Program "GTPases as Central Regulators of Cellular Function", Reisensburg Castle, Günzburg, Germany. Structure based mechanism of GTP hydrolysis in EF‐Tu. 1st Heart of Europe Meeting on Bio‐Crystallography, Walkmühle, Mühltal, Germany. Zooming in on the GTPase mechanism of EF‐Tu. 6th European Meeting on Elongation Factors, Walkmühle, Mühltal, Germany. Crystallographic studies of hyperactive EF‐Tu mutants provide evidence for a dissociative GTPase mechanism. 4th Colloquium of the German Research Foundation Priority Program "GTPases as Central Regulators of Cellular Function", Reisensburg Castle, Günzburg, Germany. Structural and mutational studies of elongation factor Tu. 7th European Meeting on Elongation Factors, Kemer, Turkey. The structural basis of the bacterial stringent response. 4th European Biophysics Congress, Alicante, Spain. Maximum‐likelihood protein crystallization. Center for Structural and Cell Biology in Medicine Seminar Series, Lübeck, Germany Structural investigations into the bacterial stringent response. Wittenberg Symposium on Infectivity and Host Cells, Wittenberg, Germany. The stringent response in bacteria: a new target for therapy? Page 14 of 21 02/07 06/07 06/07 04/09 05/11 05/11 04/12 05/13 Forum for Innovative Therapies (FIT2006): Infectious Diseases and Host Defense ‐ New Targets for Innovative Therapies, Hamburg, Germany. Crystallization of Rel/Spo‐ligand complexes: not so complex? Center for Structural and Cell Biology in Medicine Seminar Series, Lübeck, Germany Reopening the book on metal‐mediated signal termination: are Rel/Spo homologues really Mn2+‐dependent phosphohydrolases? International Mini‐Symposium on the Bacterial Stringent Response, Lübeck, Germany The stringent response in bacteria: a new target for therapy? International Mini‐Symposium on the Bacterial Stringent Response, Lübeck, Germany Conceptual frameworks and process worksheets: tools for retaining basic science knowledge in the clinical years. 2nd Medical Biochemistry Education Strategies Workshop, Myrtle Beach, SC Innovations in Medical Biochemistry Education (co‐presented with A. Trott). PLFSOM Medical Education Scholarship and Research Seminar Series, El Paso, TX. Developing and implementing a curriculum planning framework at PLFSOM. AAMC New and Developing Medical Schools Consortium, El Paso, TX Innovations in Medical Biochemistry Education (co‐presented with A. Trott). PLFSOM Internal Medicine Grand Rounds, El Paso, TX. The Association of Biochemistry Course Directors educational scholarship initiatives (co‐
presented with T.B. Fulton). 4th International Association of Biochemistry Course Directors (ABCD) Conference, La Fonda on the Plaza, Santa Fe, NM. WORKSHOPS: 03/04 08/06 05/11 08/12 Hogg, T. (2004). Protein solubility and the phase diagram: basic principles and practical applications. German Crystallographic Society ‐ Crystallization Workshop, Jena, Germany. Hogg, T. (2006). Protein solubility and the phase diagram: basic principles and practical applications. International School on Protein Crystallization (ISPC),ICCBM‐11, Quebec City, Canada. Hogg, T., Pfarr, C.M. and Piskurich, J. (2011). Organizing basic sciences within the framework of a clinical presentation. American Association of Medical Colleges (AAMC) Developing Medical Schools Consortium, El Paso, TX. Hogg, T., Baston, R.K., Woods, G., Pfarr, C. and Bramblett, D. (2012) Workshop on developing Page 15 of 21 05/13 and implementing a clinical‐presentation based medical curriculum. Host Institutions: OU School of Community Medicine & Central Michigan University College of Medicine – Tulsa, OK Fulton, T.B., Hogg, T. and Sabina, R. (2013). Revisiting, refining, and linking medial biochemistry objectives and competencies. (2013). 4th International Association of Biochemistry Course Directors (ABCD) Conference, La Fonda on the Plaza, Santa Fe, NM. ABSTRACTS: 1. 2. 3. 4. 5. 6. 7. 8. Hogg, T., Mesters, J.R., Wagner, A., Sprinzl, M. and Hilgenfeld, R. (1997). Structures of Thermus thermophilus elongation factor Tu mutants lacking conserved histidine residues. Structural Aspects of Protein Synthesis Meeting, Tällberg, Sweden Hogg, T., Mesters, J.R., Wagner, A., Sprinzl, M. and Hilgenfeld, R. (1998). Structures of Thermus thermophilus elongation factor Tu mutants lacking conserved histidine residues. 18th European Crystallographic Meeting (ECM‐18), Prague, Czech Republic. Hogg, T., Berchtold, H., Wagner, A., Sprinzl, M. and Hilgenfeld, R. (1999). Differences between the binding modes of GTP and its analogues to GTPases. 1st Symposium on Protein Structure Analysis for Biomedical Research, Murnau, Germany. Hogg, T., Mesters, J., Sprinzl, M. and Hilgenfeld, R. (1999). Highly refined 1.7 Å crystal structure of Thermus thermophilus EF‐Tu*GppNHp: multiple binding modes provide implications for catalysis. The Ribosome: Structure, Function, Antibiotics and Cellular Interactions, Helsingør, Denmark. Hogg, T. Wagner, A., Sprinzl, M. and Hilgenfeld, R. (2000). Proteolytic cleavage of bacterial elongation factor Tu as a defense mechanism against phage infection. Russian‐German Summer School on Advanced Protein Chemistry, Irkutsk ‐ Lake Baikal ‐ Moscow, Russia. Hogg, T., Mechold, U., Malke, H. and Hilgenfeld, R. (2000). Guanosine polyphosphates and Magic Spot: Crystallographic analysis of stringent response factor, RelS, from Streptococcus equisimilis. 51st Mosbach Colloquium: GTP‐binding Proteins as Central Regulators in Cell Biology, Mosbach, Germany. Hogg, T., Wagner, A., Sprinzl, M. and Hilgenfeld, R. (2001). Structural consequences of Switch I cleavage in elongation factor Tu. 9th Annual Meeting of the German Crystallographic Society (DGK), Bayreuth, Germany. Hogg, T. and Hilgenfeld, R. (2004). Crystal‐contact engineering without mutagenesis: Just add zinc! 10th International Conference on the Crystallization of Biological Macromolecules (ICCBM10), Beijing, China. Page 16 of 21 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. Hogg, T., Vasilyeva, O.V., Ovchinnikova, T.V. and Hilgenfeld, R. (2006). Trace metals, proteolytic activity, and fortuity: Crystallization of an autolytic product of E. coli Lon protease. 11th International Conference on the Crystallization of Biological Macromolecules (ICCBM11), Quebec City, Canada. Nagarajan, K., Hogg, T., Herzberg, S., Wecke, M., Blohmke, C., Schmidt, C., and Hilgenfeld, R. (2006). Structural analysis of the Plasmodium falciparum cysteine protease falcipain‐2. Acta Cryst. A62, s154. Rennenberg, A., Witt, T., Nagarajan, K., Hogg, T., Schmidt, C.L., Hilgenfeld, R., and Heussler, V. (2007). PbICP, a Plasmodium berghei inhibitor of cysteine proteases. Int. J. Med. Microbiol. 297, 26. Nagarajan, K., Alterio, V., Hogg, T., Schmidt, C.L., and Hilgenfeld, R. (2007). Intracellular feeding: Investigation of hemoglobin and myoglobin degradation by Plasmodium falciparum proteases – key to antimalarial drug design. Int. J. Med. Microbiol. 297, 34‐35. Li, H., Chen, L., Tan, J., Nagarajan, K., Pumpor, K., Hogg, T., Schmidt, C.L., Jiang, H., Shen, X., and Hilgenfeld, R. (2007). Low‐molecular‐weight inhibitors of falcipain‐2 from Plasmodium falciparum. Int. J. Med. Microbiol. 297, 34. Hogg, T., Mechold, U., Cashel, M., Malke, H. and Hilgenfeld, R. (2008). Targeting the bacterial ‘stringent response’ for structure‐based antibiotic design. 1st US‐Mexico Border Infectious Disease Forum, El Paso, TX. Peterman, N., Schmidt, C.L., Wagner, A.K., Hogg, T., Hansen, G. and Hilgenfeld, R. (2009). Structural basis for the intrinsic GTPase and GDI activities of FeoB. 17th Annual Meeting of the German Crystallographic Society, Hannover, Germany. Tobin, B., Steele, D., Arroyave, A., Pfarr, C., McMahon, K., Woods, G. and Hogg, T. (2009). Medical Education Curriculum for the 21st Century: Integration is Key Innovations in Medical Education Exhibit, 2009 AAMC Annual Meeting, Washington, DC. Piskurich, J., Kupesic, S.P., Hogg, T. and Steele, D.J. (2009). Building and effective team of basic science and clinician medical educators. SGEA 2009 Conference Proceedings. Pfarr, C.M., Kupesic, S.P., Patham, B., Janssen, H., Guerra, M., Lopez, J., Coral, L., Rodriguez, J., Brower, R., Steele, D.J. and Hogg, T. (2010). Towards a comprehensive e‐book for delivering learning materials in a clinical presentation‐based curriculum. JIAMSE 20‐2s, 201‐202. Brower, R., Steele, D., Arroyave, A., Pfarr, C., McMahon, K., Woods, G. and Hogg, T. (2010). Medical Education Curriculum for the 21st Century: Integration is Key Innovations in Medical Education Exhibit, 2010 AAMC Annual Meeting, Washington, DC. Trott, A. and Hogg, T. (2011). The integration of biochemistry into a clinical scheme‐based medical school curriculum. Association of Biochemistry Course Directors Workshop, Myrtle Beach, SC. Page 17 of 21 21. 22. 23. 24. 25. 26. 27. 28. Hogg, T., Lacy, N.L., Osborne, D. and Pfarr, C.M. (2011). Evaluating the impact of unit duration and holiday breaks on student performance: are there unwanted proximity effects? Harvard Macy Program for Educators in Health Professions, Cambridge, MA. Pfarr, C., Trott, A., Bramblett, D., Hogg, T., Osborne, D., Cooper, R., Balsiger, H. and Coue, M. (2012). Developing cell and gene therapies for Duchenne muscular dystrophy 6th Annual TTUHSC PLFSOM Research Colloquium, El Paso TX Pfarr C.M., Trott, A., Bramblett, D., Hogg, T., Osborne, D., Cooper, R., Balsiger, H. and Coue, M. (2012). A laboratory for education in molecular medicine: a dedicated resource for medical student research. (2012) Med Sci Educ., 22(4S), 293‐294 Pfarr, C.M., Baatar, D., Hogg, T., Osborne, D., Bramblett, D., Balsiger, H., Perry, C. and Brower, R. (2013). Development of a small group / large group multi‐use educational space. (2013). Video Tour Presentation at 2013 AAMC Annual Meeting, Philadelphia, PA. Pfarr, C.M., Baatar, D., Bramblett, D., Brower, R. and Hogg, T. (2014). Developing a comprehensive assessment system in a clinical presentation‐based curriculum Harvard Macy Program for Educators in the Health Professions, Cambridge, MA. Mendel J.T., Rivera S., Parada J., Lavezo J., Paul J. and Hogg T. (2014). Overproduction of T. thermophilus wild‐type and H85L elongation factor Tu. TTUHSC PLFSOM Student Activity and Research Program (SARP) Symposium, El Paso, TX. Lavezo J., Mendel J.T., Rivera S., Parada J., Paul J. and Hogg T. (2014) Protein purification and crystallization screening of Thermus thermophilus EF‐Tu H85L mutant. TTUHSC PLFSOM Student Activity and Research Program (SARP) Symposium, El Paso, TX. Rivera S., Parada J., Mendel J.T., Lavezo J., Paul J. and Hogg T. (2014) Purification and X‐ray structural analysis of bacterial elongation factor Tu (EF‐Tu): a step towards the rational design of novel antibiotics. TTHUSC El Paso 2nd Annual Infectious Diseases Symposium, El Paso, TX. PUBLICATIONS: 1. 2. 3. Hogg, T., Mesters, J.R., Hornung, V., Wagner, A., Sprinzl, M. and Hilgenfeld, R. (1999). Structure‐
function studies of His85Leu elongation factor Tu from Thermus thermophilus in complex with the GTP analogue, GppNHp. EMBL‐DESY Photon Science Reports 1999. Hogg, T., Mechold, U., Malke, H., Hilgenfeld, R. (1999). Crystallographic analysis of bacterial stringent response factor, RelS, from Streptococcus equisimilis. EMBL‐DESY Photon Science Reports 1999. Hilgenfeld, R., Mesters, J.R. and Hogg, T. (2000). Insights into the GTPase mechanism of EF‐Tu from structural studies. In: The Ribosome: Structure, Function, Antibiotics and Cellular Interactions (R.A. Garrett, S.R. Douthwaite, A. Liljas, A.T. Matheson, P.B. Moore, and H.F. Noller, Page 18 of 21 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. eds.), ASM Press, Washington, D.C., pp. 347‐357. Hogg, T., Smatanova, I., Ulbrich, N. and Hilgenfeld, R. (2001). Crystal structure determination of the pokeweed antiviral protein (PAP) from Phytolacca acinosa to 1.7 Å resolution. EMBL‐DESY Photon Science Reports 2001. Rau, A., Hogg, T., Marquardt, R. and Hilgenfeld, R. (2001). A new lysozyme fold: Structure of the muramidase from Streptomyces coelicolor at 1.65 Å resolution. J. Biol. Chem. 276, 31994‐31999. Hogg, T., Petterson, S. and Hilgenfeld, R. (2001). High‐resolution structure determination of the monoclinic crystal form of a long‐acting insulin derivative, HOE901 (“insulin glargine”). EMBL‐
DESY Photon Science Reports 2001. Hogg, T., Mechold, U., Cashel, M., Malke, H. and Hilgenfeld, R. (2001). Preliminary crystal structure determination of the stringent response factor from Streptococcus equisimilis. EMBL‐
DESY Photon Science Reports 2001. Hogg, T., Smatanova, I.K., Bezouska, K., Ulbrich, N. and Hilgenfeld, R. (2002). Sugar‐mediated lattice contacts in crystals of a plant glycoprotein. Acta Cryst. D58, 1734‐1739. Hogg, T., Mesters, J.R. and Hilgenfeld, R. (2002). Inhibitory mechanisms of antibiotics targeting elongation factor Tu. Current Protein & Peptide Science 3, 121‐131. Mesters, J.R., Hogg, T. and Hilgenfeld, R. (2003). G proteins. In: Encyclopedia of Life Sciences, Nature Publishing Group, Macmillan Publishers, London. Hogg, T. and Mesters, J.R. (2003). Structural investigations into the mechanism of reversible CO2 hydration by human carbonic anhydrase isozymes I and II at atomic resolution. EMBL‐DESY Photon Science Reports 2003. Smatanová, I.K., Hogg, T., Hilgenfeld, R., Grandori, R, Carey, J, Vácha, F, and Štys, D. (2003) Proteins and their crystals. Materials Structure 10, 30‐31. Schmidt, H., Hilgenfeld, R. and Hogg, T. (2004). Activation of human carbonic anhydrase. EMBL‐
DESY Photon Science Reports 2004. Hogg, T., Mechold, U., Malke, H., Cashel, M., and Hilgenfeld, R. (2004). Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response. Cell 117, 57‐68. Mesters, J.R., Hogg, T., Küttner, E.B., Weiss, M.S., Smatanova, I.K. (2004). Glycosylation can be essential for crystallization. In: Zeitschrift für Kristallographie, Suppl. Issue 21, Gemeinsame Jahrestagung der Deutschen Gesellschaft für Kristallographie (DGK) und der Deutschen Kristallwachstum und Kristallzüchtung (DGKK), Oldenbourg, München. Nagarajan, K., Hogg, T., Blohmke, C.J., Schmidt, C.L. and Hilgenfeld, R. (2005). Structural analysis of the Plasmodium falciparum cysteine protease falcipain‐2. EMBL‐DESY Photon Science Reports 2005. Page 19 of 21 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. Hogg, T. and Hilgenfeld, R. (2005). Structure‐based mechanistic analysis of (p)ppGpp synthesis by members of the RelA/SpoT superfamily. EMBL‐DESY Photon Science Reports 2005. Hogg, T., Vasilyeva, O.V., Ovchinnikova, T.V. and Hilgenfeld, R. (2005). Structural characterization of an autolytic product of Escherichia coli Lon protease. EMBL‐DESY Photon Science Reports 2005. Wrase, R., Elger,W., Hillisch, A. and Hogg, T. (2005). Crystallographic studies of human carbonic anhydrase isozymes I and II in complex with estrogen sulfamates. EMBL‐DESY Photon Science Reports 2005. Hogg, T., Nagarajan, K., Herzberg, S., Chen, L., Shen, X., Jiang, H., Wecke, M., Blohmke, C., Hilgenfeld, R., and Schmidt, C.L. (2006). Structural and functional characterization of falcipain‐2, a hemoglobinase from the malarial parasite Plasmodium falciparum. J. Biol. Chem. 281, 25425‐
25437. Petermann, N., Schmidt, C.L., Wagner, A, Hilgenfeld, R. and Hogg, T. (2006) Crystallographic studies on the bacterial iron transport protein, FeoB. MAX‐lab Activity Report 2005‐2006, pp. 389‐390. Petermann, N., Schmidt, C.L., Wagner, A., Hogg, T., and Hilgenfeld, R. (2007) Crystallographic studies on NFeoB, a protein involved in ferrous iron uptake of bacteria. EMBL‐DESY Photon Science Reports 2007. Hogg, T. and Hilgenfeld, R. (2007). Lead Search and Optimization: Protein Crystallography in Drug Discovery. In: Comprehensive Medicinal Chemistry II, Vol. 3 (J. Taylor, D. Triggle and H. Kubinyi, eds.), Elsevier, Amsterdam, pp. 875‐900. Pfarr, C.M., Bramblett, D., Osborne, D., Trott, A., Balsiger, H., Coue, M., Brower, R. and Hogg, T. (2013). A laboratory for education in molecular medicine: a dedicated resource for medical student research. Med. Sci. Educ. 23(1S), 108‐118. Sabina R.L., McKee E.E., Osheroff N., Fulton T.B., Franklin D.S., Hogg T., Kearney K.R., King S.C., Niederhoffer E.C., Noramly S., Thompson K., & Wimmer M.J. (2013). Teaching biochemistry to students of medicine, pharmacy & dentistry. Med. Sci. Educ. 23(3); 394‐399. Hogg T., Mendel J.T. and Lavezo J. (2015). Structural analysis of a type 1 ribosome inactivating protein reveals multiple Asn‐GlcNAc monosaccharide modifications: Implications for cytotoxicity. Molecular Medicine Reports (in press) Page 20 of 21 DOCTORAL DISSERTATION: 2001 Hogg T. Crystallographic investigations on ribosome‐associated GTP‐binding proteins. German National Library (Deutsche National Bibliothek) http://d‐nb.info/964287307 Page 21 of 21