Human CD Antigens
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Human CD Antigens B Cell Antigens CD5 CD19 CD20 CD22 CD23 CD25 CD40 CD69 CD70 CD79a CD79b CD80 CD86 CD137 (4-1BB) CD138 (Syndecan) CD252 CD268 Dendritic Cell Antigens CD1a CD1b CD1c CD11c CD14 CD40 CD49d CD80 CD83 CD85g (ILT7)pDC CD86 CD123pDC CD197 (CCR7) CD205 (DEC-205) CD207 (Langerin) CD209 (DC-SIGN) CD273 (B7-DC) CD289 (TLR9) CD303 (BDCA2) CD304 (BDCA4) Endothelial Cell Antigens CD31 (PECAM-1) CD34 CD54 CD61 CD62E (E-Selectin) CD105 (Endoglin) CD106 (VCAM-1) CD144 (VE-Cadherin) CD146 CD202b (Tie2) CD309 (FLK1) Antigen Name CD1a CD1b CD1c CD1d CD1e Alternate Names T6, Leu-6, R4, HTA1 R1 R7, M241 R3 R2 MW (kD) 49 45 43 49 28 CD2 CD2R CD3δ T11, LFA-2, SRBC-R T11-3 T3D 50 50 20 Distribution cortical thymocytes, Langerhans, DC cortical thymocytes, Langerhans, DC cortical thymocytes, Langerhans, DC, B subset cortical thymocytes, intestinal epithelial cells DC (Golgi compartments, endosomes, and lysosomes) thymocytes, T, NK, B Tact T, thymocyte subset CD3ε T3E, Leu-4 20 T, thymocyte subset CD3γ T3G 25 T, thymocyte subset CD4 CD5 CD6 CD7 T4, Leu-3a T1, Tp67, Leu-1 T12 Leu-9, gp40 55 67 100-130 40 CD8α CD8β CD9 CD10 CD11a T8, Leu-2 Leu-2 p24, MRP-1 CALLA, NEP, gp100 LFA-1, integrin αL, ITGAL Mac-1, integrin αM, CR3, ITGAM p150,95, CR4, integrin αX, ITGAX 32-34 30-32 22-27 100 180 170 thymocyte subset, T subset, monocyte thymocytes, T, B subset, B-CLL thymocytes, T, B subset hematopoietic progenitors, thymocytes, T, NK, T-ALL thymocyte subset, T subset, NK thymocyte subset, T subset pre-B, eosinophils, basophils, platelets, Tact B precursors, T precursors, neutrophils lymphocytes, granulocytes, monocytes, macrophages myeloid, NK, monocytes 150 DC, myeloid, NK, B subset, T subset adhesion, migration, heterodimer with CD18 monocytes, granulocytes, platelets myeloid cells, AML zinc-binding metalloproteinase corona virus receptor CD101 CD102 CD103 LPS sensor adhesion LPS receptor CD104 adhesion CD62L, CD62P CD11b CD11c CD12 CD13 CD14 CD15 90-120 Aminopeptidase N, 150-170 APN, gp150 LPS-R 53-55 Lewis-x, Lex, SSEA-1 CD15s Sialyl Lewis X CD15u CD16a Sulfated Lewis X FcγRIIIA 50-65 monocytes, tissue macrophages granulocytes, neutrophils, eosinophils, monocytes neutrophils, eosinophils, monocytes, memory T, Tact, B, NK, HEV myeloid subset neutrophils, macrophages, NK, mast CD16b FcγRIIIB 48 neutrophils CD17 115-165 CD18 lactosylceramide, LacCer Integrin β2, ITGB2 95 neutrophils, monocytes, platelets, granulocytes, basophils, B subset all leukocytes CD19 B4 95 B, FDC CD20 CD21 CD22 CD23 CD24 CD25 B1, Bp35 C3DR, CR2, EBV-R BL-CAM, Siglec-2 FcεRII BA-1, HSA Tac, p55, IL-2Rα 33-37 110, 145 150 45 35-45 55 CD26 CD27 DPP IV T14, TNFRSF7, S152 110 50-55 CD28 CD29 Tp44, T44 Integrin β1, platelet GPIIa, ITGB1 Ki-1, Ber-H2 44 130 CD30 CD31 CD32 Granulocyte Antigens CD10 CD11b CD11c CD14low CD15 CD16b CD31 CD33 CD66b CD88 CD181 (CXCR1) CD182 (CXCR2) CD217 (IL-17RA) CD11a CD11b CD11c CD14 CD15low CD33 CD64 CD68 CD80 CD85 (ILT) family CD86 CD105 (Endoglin) CD115 CD163 CD195 (CCR5) CD282 (TLR2) CD284 (TLR4) PECAM-1, endocam, 130-140 GPIIa FcγRII 40 CD33 p67, Siglec-3, My9 67 CD34 My10, Mucosialin, gp105-120 CR1, C3b/C4bR, Immune adherence receptor GPIV, GPIIIb, OKM5 antigen, PASIV 105-120 CD35 CD36 250 88 CD9 CD31 (PECAM-1) CD41 CD42b CD51 CD61 CD62P (P-Selectin) CD122 CD158 (KIR) family CD161 CD244 CD314 (NKG2D) CD319 (CRACC) CD328 (Siglec-7) CD34 CD38low CD90 CD105 (Endoglin) CD110 CD111 CD117 (c-Kit) CD133 CD135 (Flt3) CD184 (CXCR4) CD202b (Tie1) CD243 (MDR1) CD309 (FLK1) CD338 (ABCG2) platelets, megakaryocytes platelets, megakaryocytes leukocytes, except resting B, plateletslow 80-95 leukocytes, endothelial, epithelial adhesion, migration CD44var (v4) CD44var (v10) CD44 variant 1-10 CD45 CD45R CD45RA CD45RB LCA, PTPRC, T200 B220 CD45RC CD45R0 180-240 220 205-220 190-220 190-220 180 CD46 MCP 56-76 CD47 IAP, neurophilin 45-60 CD47R MEM-133 120 CD48 CD49a Blast-1, Hulym3 VLA-1, Integrin α1, ITGA1 VLA-2, Integrin α2, ITGA2 VLA-3, Integrin α3, ITGA3 VLA-4, Integrin α4, ITGA4 VLA-5, Integrin α5, ITGA5 VLA-6, Integrin α6, ITGA6 ICAM-3 CD49d CD49e CD49f CD50 CD51 B differentiation/ costimulation, isotype-switching, rescues B cells from apoptosis heterodimer with CD61, platelet activation and aggregation 60 80 65-75 64 CD130 IL-6Rβ, gp130, IL6ST 130 CD154 CD131 95-120 vitronectin, fibrinogen, fibronectin, vWF, thrombospondin vWF and thrombin CD132 CFS2RB, IL-3R common β Common γ, IL2RG 120 CD134 CD135 CD136 AC133, prominin-like 1, PROM1 OX-40, TNFRSF4 Flt3/Flk-2 MSP-R, RON, MST1R 48-50 130-150 180 CD137 CD138 4-1BB, TNFRSF9 Syndecan-1 30 80-150 vWF and thrombin vWF and thrombin vWF and thrombin CD54, hyaluronic acid hyaluronin CD147 28 leukocytes, erythrocytes, platelets, endothelial adhesion adhesion, metastasis hyaluronin hyaluronin, osteopontin, fibronectin CD151 exon C isoforms of CD45 isoform of CD45 lacking A, B, C exons CD152 CD153 CD154 membrane cofactor protein leukocyte adhesion, migration, activation adhesion adhesion adhesion regulates complement-mediated cell lysis T subset, platelets, thymic epithelium, astrocytes T subset, Bact T subset platelets, megakaryocytes, macrophages, endothelial activated endothelium costimulation B, naïve T, memory T, monocytes, granulocytes, NK, thymocytes plateletsact, endothelial, megakaryocytes adhesion, leukocyte homing and rolling CD72 CD73 Ly-32.2, Ly-19.2 NT5E 42 69 CD74 Ii, invariant chain CD75 CD75s 33, 35, 41, 43 67, 85 110 CD85b CD85c LIR8, LILRB5 CD85d Cd85e LIR2, ILT4, MIR10, LILRB2 ILT6, LIR4, LILRA3 CD85f ILT11, LIR9, LILRA5 CD85g CD85h LIR4, ILT7 LIR7, ILT1, LILRA2 CD85i ILR6, LILRA1 CD85j LIR1, ILT2, MIR-7, LILRB1 110 55 53 110 T and B cell costimulation proliferating cells, reticulocytes, erythroid iron uptake precursors B, FDC, macrophages B proliferation B subset, T subset, FDC, epithelial, endothelial ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph adhesion B, macrophages, monocytes, Langerhans, MHC class II traffic and function, maturation of DC, Tact follicular B cells B subset, epithelial lactosamines B subset, T subset a-2,6-sialylated lactosamines (previously CDw75 and CDw76) germinal center B, Burkitt’s lymphomashigh, apoptosis follicular lymphomaslow B component of BCR, BCR surface expression and signal transduction B component of BCR, BCR surface expression and signal transduction Bact and Tact, macrophages, DC T costimulation B, T, NK, thymocytes, DC, endothelial, complex w/ CD19, CD21 and CD225, signaling, T fibroblast, neuroblastomas, melanomas costimulation leukocytes, fibroblast, epithelial, endothelial signal transduction, associates with MHC-I, MHC-II, CD37, CD52, CD81 and β1 integrins mature DC, Langerhans, Bact and Tact dendritic cell marker thymocytes, monocytes, plateletslow, B, T putative role in adhesion, costimulation subset, tissue macrophages monocytes, macrophages, DC, granulocytes, suppression of NK cell-mediated cytotoxicity T subset NK, T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcRγ NK, T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcRγ NK, monocytes, macrophages suppression of NK cell-mediated cytotoxicity, associates with HLA -G, -B, -G1 B, NK activation of NK-mediated cytotoxicity, associates with FcRγ monocytes, neutrophils, macrophages, DC activation of NK-mediated cytotoxicity, associates with FcRγ pDC signaling for cytokine production monocytes activation of NK-mediated cytotoxicity, associates with FcRγ T subset, monocytes, macrophages, DC, B activation of NK-mediated cytotoxicity, associates with FcRγ DC, monocytes., T, mature B suppression of NK cell-mediated cytotoxicity, associates with HLA -A, -B, -C 42-45 CD158a KIR2DL1, p58.1 50-58 CD158b1 KIR2DL2, p58.2 50-58 CD158b2 KIR2DL3, p58.2 50-58 CD158d KIR2DL4 41 CD158e KIR3DL1 70 CD158f KIR2DL5A 50-58 CD158g KIR2DS5 CD158h KIR2DS1 50 CD158i KIR2DS4 35, 58 CD158j KIR2DS2 50 CD158k KIR3DL2 70 CD158z KIR3DL3 CD159a NKG2A, KLRC1 43 CD159c NKG2C, KLRC2 40 CD160 CD161 CD162 BY55,NK1, NK28 NKR-P1A, KLRB1 PSGL-1 27 40 120 CD162R CD163 110-140 130 CD164 PEN-5 M130, GHI/61, D11, RM3/1 MGC-24, MUC-24 CD15s,CD34, CD57, CD162, GlyCAM-1, MAdCAM-1 CD15s, CD162 CD165 CD166 CD167a CD168 AD2, gp37 ALCAM DDR1 RHAMM 42 105 120 84-88 monomeric and aggregated IgG CD169 CD170 sialoadhesin, Siglec-1 185 Siglec-5, CD33-like2 140 CD171 L1 200-210 CD172a SIRPa, SHPS-1 110 CD172b SIRPβ1 50 CD172g CD173 45-50 56-62 38-42 16-18 neutrophil subset Tact, testis, neutrophil, monocytes, NK pro- and pre-B 80 HSC, embryonal tissue, monocytes, stromal cells lymphocytes, thymocytes, platelets, epithelial neurons, monocytes, epithelial, fibroblasts, Tact epithelial, DC myelomonocytic lineage and DC monocytes, macrophages, granulocytes T subset, stem monocytes, granulocytes, DC CD236 CD236R CD238 CD239 CD240CE CD240D CD241 CD242 Glycophorin C/D Glycophorin C Kell B-CAM Rh30CE, RHCE Rh30D, RhD, RH1 RhAg, Rh50 ICAM-4 32, 23 32 93 78-85 30-32 30-32 50 42 erythrocytes, stem cell subset erythrocytes, stem cell subset erythrocytes, stem cell subset erythrocytes, stem cell subset, fibroblasts erythrocytes erythrocytes erythrocytes erythrocytes major sialoglycoproteins of the erythrocyte membrane, antigenic determinants for the MN and Ss blood groups Gerbich blood group antigen Gerbich blood group antigen zinc endopeptidase adhesion, signaling Rh blood group system Rh blood group system complex with CD47, LW, glycophorin B adhesion, Landsteiner-Wiener blood group CD243 CD244 CD245 180 70 220-240 CD246 MDR-1, p170, P-gp 2B4, p38 , NKLR2B4 p220/240, DY12, DY35 ALK CD247 TCRζ, CD3ζ 16 stem cells, endothelial, epithelial T subset, monocytes, basophils, NK lymphocytes, platelets, monocytes, granulocytes, NK anaplastic T cell leukemias, small intestine, testis, brain T, NK subset CD248 CD249 CD252 TEM1, Endosialin Aminopeptidase A OX-40 Ligand, gp34, TNFSF4 TRAIL, APO-2L, TL2, TNFSF10 TRANCE, RANKL, TNFSF11 TNFSF12, TWEAK, APO3L APRIL, TALL-2, TNFSF13 BLyS, BAFF, TNFSF13b 175 160 34 endothelial tissue, stromal fibroblasts epithelial, endothelial B, DC, mast, endothelial, cardiac myocytes TCR complex subunit, coupling of antigen recognition to signaling tumor angiogenesis associates with angiotensin II and cholecystokinin-8 T costimulation CD134 32 T, DC, Bact, NK, monocytes apoptosis SCF LIF Ifnγ TNFα, TNFβ TNFα, TNFβ IL-1α, IL-1β, IL1ra IL-3 CD256 CD257 IL-4, IL-13 IL-5 IL-6 IL-7 IL-9 oncostatin M, IL-6, LIF CD252 FLT3 ligand MSP, HGF1 4-1BB ligand ECM adhesion CD62E IGLL1, IGO 22 pro- and pre-B CD180 CD181 RP-105, LY64 CXCR1, IL-8RA 95-105 39 CD182 CXCR2, IL-8RB 40 CD183 CXCR3 40 CD184 CXCR4, fusin 45 CD185 CXCR5, BLR1 45 CD186 CD191 40 39 CD192 CXCR6, BONZO CCR1, MIP-1αR, RANTES-R CCR2, MCP-1-R CD193 CCR3, CKR3 45 B subset, monocytes, DC neutrophils, basophils, NK, T subset, monocytes neutrophils, basophils, NK, T subset, monocytes eosinophils, Tact, NK, GM-CSF activated CD34+ progenitors B, DC, T subset, monocytes, endothelial, epithelial, granulocytes mature B, T subset, monocytes and Burkitt Lymphoma cells Tact, B subset, NK subset T, monocytes, macrophages, NK, DC, stem cell subset NKact, monocytesact, basophils, macrophages, T subset, B, endothelial eosinophils, basophils, T subset CD195 CCR5 45 CD196 CCR6, LARC receptor, DRY6 CCR7, EBI-1 CCR8, GPRCY6, TER1 CCR9, GPR-9-6 45 45-50 48 50 150 130-150 CD204 CD205 CD206 OX-2 OX-2R EPC-R, PROCR Tie2, Tek ENPP3, PDNP3, PD-1b MSR-1, SRA DEC-205 MRC1 T subset, DC subset, B T, high in Th2, NK, monocytes subset of memory T, lamina propria mononuclear cells thymocytes, endothelial, Bact, Tact myeloid lineage endothelial subset stem cells, endothelial basophils, mast, glioma cells, HSC 220 205 180 macrophages, DC DC, thymic epithelial DC subset, macrophages CD207 Langerin 40 Langerhans, DC 40 45 50 43 lymphocytes, monocytes, macrophages and immature DC T subset, B, DC subset, Langerhans polio virus, CD96 pleiotrophin, midkine CD261, CD262, CD263, CD264, OPG osteoclast differentiation, enhances DC stimulation of CD265, OPG naïve T proliferation induces apoptosis, promotes angiogenesis CD266 CD270, LTβR CD253 60 leukocytes induces apoptosis via FADD and caspase 8 CD253 65 T, B, NK, macrophages, monocytes, granulocytes T, B, NK, macrophages, monocytes, granulocytes broad expression, DC, osteoclasts inhibits CD253 mediated apoptosis CD253 decoy receptor, inhibits apoptosis CD253 osteoclastogenesis, T-DC interactions CD254 14 vascular endothelial and epithelial cells, keratinocyte cell-matrix interactions and endothelial growth and migration CD255 32 25 B, myeloma B, T subset involved in the stimulation of T cell function mature B survival CD256, CD257 CD257 20 mature B (membrane and perinuclear), plasma cells T, monocytes, DC B survival and proliferation CD256, CD257 stimulatory and inhibitory signaling 33 25 CD276 CD277 CD278 CD279 ICOS, AILIM PD1, SLEB2, PDC1 55-60 55 CD280 UPARAP, MRC2 180 CD281 TLR1 90 CD282 TLR2 90 CD283 TLR3 100 CD284 TLR4 100 CD286 TLR6 90 CD288 TLR8 110 CD289 CD290 CD292 CD293 CD294 CD295 CD296 TLR9 TLR10 BMPR1A, ALK3 BMPR1B, ALK6 CRTH2. GPR44 LeptinR, LEPR ART1, RT6, ART2 120 90 57 57 55-70 132 37 CD297 ART4, dombrock blood group, DOK1 ATP1β3 DC-SIGN-related, LSIGN, DC-SIGN2, CLEC4M CMRF35H, IRC1, IRp60 CMRF35A, LIR 35 97 33 60 40-45 56 B cell growth factor and costimulator of Ig production CD267, CD268, CD269 neurons (Schwann cells), BM mesenchymal cells, DC subset, monocytes Tact, Bact , Th1, macrophages, DC DC subset, monocytes, macrophages mediates cell survival as well as cell death CD258, CD272, HSV-1, HSV-2 NGF, BDNF, NT-3, NT-4 attenuation of T-cell activation costimulation or suppression of T proliferation CD270 CD279 macrophages, epithelial, DC, NK, monocytesact, Tact, Bact endothelial, macrophages, DC, T, B, monocytesact epithelial, NK, monocytesact, B, T, DC subset B, T, NK, DC, monocytes, endothelial, stem cell subsets Tact, Th2 Tact , Bact, thymocytes costimulation or suppression for T cells CD279 costimulation, cytokine production CD278 regulation of T cell-mediated immune response regulator of T cell activation and function T costimulation CD275 associated with apoptotic programmed cell death and CD273, CD274 the inhibition of T cell proliferation collagen matrix remodeling and endocytic recycling collagen chondrocytes, osteoclasts, osteocytes, endothelial, macrophages DC, keratinocytes, macrophages, monocytes, neutrophils monocytes, macrophages, granulocytes, keratinocytes, DC, neutrophils fibroblasts, epithelial, myeloid DC (may be intracellular) monocytes, DC, macrophages, granulocytes, endothelial, Tact macrophages, monocytes, epithelial, endothelial leukocytes, monocytes, DC innate immune response to bacterial LPS, associates with MD2 and CD14 innate immune response to bacterial LPS, associates with MD2 and CD14 pathogen recognition, activation of innate immunity 38 pDC (intracellular), Bact pDC, Bact bone progenitor cells, chondrocytes, epithelial epithelial, mesenchymal and bone progenitors Th2, eosinophils, basophils hematopoietic cells heart and skeletal muscle, T subset, NK, neutrophils, epithelial erythroid, T, monocytesact pathogen recognition, activation of innate immunity pathogen recognition, activation of innate immunity bone development bone development stimulatory effects on Th2, allergic inflammation adipose metabolism, immune dysfunction in obesity ADP ribosylation of target proteins, associates with PDGFβ, integrins and defensin ADP ribosylation of target proteins 52 all leukocytes 45 endothelial subset transport sodium and potassium ions across membrane pathogen recognition receptor 60 pathogen recognition, activation of innate immunity, associates with CD282 pathogen recognition, activation of innate immunity, associates with CD281 and CD286 pathogen recognition, activation of innate immunity CD300e CD300f CD301 CD302 CD303 CD304 CMRF35L IREM1, MAIR-V MGL, HML, CLEC10A DCL1, BIMLEC BDCA2, HECL BDCA4, neuropilin 1, NRP1 45 60 38 19-28 38 130 T subset, B, monocytes, mast, granulocytes, NK, neutrophils, DC monocytes, neutrophils, NK, DC, B and T subsets monocytes, macrophages, neutrophils myeloid immature DC, macrophages macrophages, granulocytes, monocytes, DC pDC, neutrophils, macrophages neurons, Treg, DC, endothelial CD305 CD306 LAIR1 LAIR2 32-40 16 NK, B, T, monocytes, DC monocytes, T CD307a FCRL1 55-105 B subset, B lymphoma CD307b FCRL2 B subset HLA-E CD307c CD307d FCRL3 FCRL4 B subset B subset HLA-C CD307e FCRL5 B subset CD62P, CD62E, CD62L CD309 VEGFR2, KDR 230 CD62L CD312 EMR2 90 CD314 NKG2D, KLRK1 42 CD315 135 CD317 CD318 CD319 CD320 CD9P1, SMAP6, FPRP, PTGFRN EWI2, PGRL, CD81P3, KASP, IGSF8 BST2, HM1.24 CDCP1, SIMA135 CRACC, SLAMF7 8D6A, 8D6 CD321 JAM1, F11R 35 CD322 JAM2, VE-JAM 43 CD324 E-Cadherin, CDH1 120 CD325 140 CD326 CD327 N-Cadherin, NCAD, CDH2 EpCAM, TACSTD1 SIGLEC6 35-40 49 CD328 SIGLEC7, AIRM-1 75 CD329 SIGLEC9 50 B cell growth and development cell adhesion with ECM regulates T and NK cells development of germinal centers and proliferation of B cells endothelial, epithelial, erythrocytes, platelets, formation of tight junctions neutrophils, monocytes, lymphocytes HEV, endothelial, B, monocytes, T subsets cell adhesion, lymphocyte homing to secondary lymphoid organs, formation of tight junctions non-neural epithelial, stem cells, cell adhesion, homotypic interaction erythroblasts, keratinocytes, trophoblasts, platelets endothelial , stem cells, muscle cells, forms a complex with catenins that is linked to the osteoblasts, neurons, BM stromal cells actin cytoskeleton epthelial cell adhesion, metastatic carcinoma cell marker placenta, spleen, B, neutrophils, granulocytes adhesion, cell-cell interactions trophoblasts may inhibit regulation of T cell and NK cell activation resting and activated NK, granulocytes, monocytes, T neutrophils, monocytes negative regulation of immune responses CD331 30 fibroblasts, epithelial, endothelial CD332 FGFR1, Fms-like tyrosine kinase-2, KAL2, N-SAM FGFR2, BEK, KGFR 115-135 fibroblasts, epithelial, mesenchymal cells CD333 FGFR3, ACH, CEK2 115 fibroblasts, epithelial CD334 FGFR4, JTK2, TKF 110 CD335 NKp46, NCR1 46 lymphocytes, macrophages, fibroblasts, skeletal muscle, epithelial NK CD336 NKp44, Ly-95 44 homolog, NCR2 NKp30, Ly-117, NCR3 30 HLA-G HLA-B HLA-B HLA-C CD300c HLA-C HLA-C HLA-E CD6 collagen CD43, CD206, CD227 α2,3- and α2,6-linked sialic acid CD9, CD24, CD56, CD142, CD166, CD171, neurocan, phosphocan, laminin CD47 CD47 CD95 IL-8 IL-8, GRO-α, β, γ and NAP-2 CXCL13 CD316 CD337 coreceptor for SIV, strains of HIV-2 and m-tropic HIV-1 CXCL16 binds C-C type chemokines CCL4, CCL5, CCL6, CCL14, CCL15, CCL16, CCL23 alternative coreceptor for HIV-1 CCL2, CCL8, CCL16 CCL11, CCL26, CCL7, CCL13, CCL15, CCL24, CCL5, CCL28 CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, CCL16 CCL20 cell migration to secondary lymphoid tissue CCL19, CCL21 allergic inflammation, alternative coreceptor for HIV-1 CCL1 cell migration, alternative coreceptor for HIV-1 CCL25 inhibition of immune response inhibitory receptor, inhibits TNFα secretion involved in blood coagulation receptor tyrosine kinase involved in angiogenesis ectoenzyme, binding to and clearance of extracellular nucleotides endocytosis of macromolecules endocytic receptor for antigen up-take/processing phagocytosis and pinocytosis of mannose containing molecules endocytic receptor brain development, implicated in ALK lymphomas B cell survival and activation induces apoptosis via FADD and caspase 8 BTLA B7DC, PD-L2, PDCD1L2, PDCD1LG2 B7-H1, PD-L1, PDCD1LG1 B7-H2, ICOSL, B7RP1, GL50, ICOSLG B7-H3 BT3.1, BTF5, BTN3A1 CD300a CD48 28 57 CD272 CD273 HLA-C ATP-dependent efflux transporter NK activation, T costimulation signal transduction; costimulation of T and NK DC, monocytesact, B, macrophages, myeloid cells Tact, monocytesact Tact 45 CD299 OX-2R CD200 protein C angiopoietin-1 nucleotides LDL oligomannose-containing carbohydrates mannose-bearing glycoproteins and glycolipids CD338 CD11a/CD18, CD11b/ CD18, CD51, CD29, integrin β5 31 NGFR, TNFRSF16 CD275 laminin α5 chain CD267, CD269 CD271 CD274 CXCL1, CXCL5, CXCL8, CCL2, CCL5, CCL7 CD170, influenza virus, erythrocyte binding antigen (EBA-175) of Plasmodium falciparum monocytes, macrophages, leukocytes, myeloid B proliferation, apoptosis 30 CD267 CD268 adhesion, costimulation, homophilic interaction protects cells from apoptosis marker for T-ALL associates with CD108 and poxvirus semaphorin-like protein A39R anion exchanger pump, transport of CO2, linking red cell membrane to cytoskeleton chemokine decoy receptor iron, pro-UPA, plasminogen CD229 16 TNFRSF14, HVEM CD264 HLA-C cell migration binds β-defensins lymph node and BM stroma, Tact, osteoblasts, osteoclasts 18, 30-35 endothelial cells, smooth muscle, fibroblasts 35 CD270 CD263 CD298 CXCL12, HIV-1 coreceptor for HIV-1 80 CD269 CD262 HLA-C associates with CXCL-10 (IP10), CXCL9 (Mig) and CXCL11 (I-TAC), chemotaxis of T cells cell migration and HIV entry alternative coreceptor for HIV-1 95, 110 35 30-45 200 LIGHT, TNFSF14 TRAIL-R1, DR4, TNFRSF10a TRAIL-R2, DR5, TNFRSF10b TRAIL-R3, DcR1, LIT, TNFRSF10c TRAIL-R4, TRUNDD, DcR2, TNFRSF10D RANK, TRANCE-R, ODFR, TNFRSF11A TWEAK-R, FGFinducible 14, TNFRSF12A TACI, TNFRSF13B BAFFR, TR13C, TNFRSF13C BCMA, TNFRSF17 CD266 CD144, β-catenin induces apoptosis B cell differentiation/signaling, associates with CD179b and IgM B cell differentiation/signaling, associates with CD179a and IgM B cell activation, LPS signaling, associates with MD-1 neutrophil chemotaxis, phospholipase D activation, repiratory burst chemotaxis of neutrophils CD258 CD261 CD265 adhesion, endothelium biology adhesion, signaling CD254 CD255 angiotensin I, bradykinin putative role in intracellular adhesion, hematopoietic progenitor cell-stromal cell interaction adhesion, thymocyte-thymic epithelium interaction migration, adhesion tyrosine kinase, adhesion associates with CD44, adhesion, tumor migration, metastasis adhesion, cell-cell and cell-matrix interactions adhesion CD253 IL-1α, IL-1β, IL1ra IL-2, IL-15 angiotensin converting enzyme putative role as co-factor to pro-coagulant y precursor for ABO antigens putative role in tumor metastasis putative role in tumor metastasis CD179b CD200 CD200R CD201 CD202b CD203c erythrocytes factor VIIa stem cell subset, epithelial stem cell subset erythroblasts, epithelial, endothelial stem cell subset,erythrocytes, endothelial CD27 CD197 CDw198 CDw199 20 initiator of clotting T, NK, B erythrocytes, stem cell subset CD177 CD178 CD179a CD28, CD152 Glycophorin B PDGF-B thrombin negative regulation of RTK-coupled signaling, associates with DAP12 negative regulation of RTK-coupled signaling biosynthetic precursor of the A and B antigens oxidized LDL Shiga toxin, verotoxin 1 CD235b tyrosine kinase receptor initiation of protein C anticoagulant signal tissue macrophage subset macrophage subset, neutrophils, DC, monocytes glial cells, monocytes, T subset, B, DC, neurons adhesion and migration CD174 CD175 CD175s CD176 CD5, CD100 major sialoglycoproteins of the erythrocyte membrane, antigenic determinants for the MN and Ss blood groups PDGF-A, PDGF-B, PDGF-C cell migration and adhesion, associates with CD113 leukocyte extravasation, adhesion cleaves membrane proteins (TNF, TGFα) to generate soluble forms proteolytic cleavage of cell-surface molecules including Notch, TNF-α, APP and ephrin-A2 granulocytes, monocytes, B progenitors, ADP-ribosyl-cyclic ADP-ribose hydrolase activities, endothelial pre-B cell growth NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset activation of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor NK subset, T subset inhibition of NK cell cytolytic activity, MHC class-I specific NK receptor T subset, NK associates with CD94, inhibition of NK cell cytolytic activity T subset, NK associates with CD94, inhibition of NK cell cytolytic activity NK subset, T subset costimulation of CD8 T T subset, NK NK cell-mediated cytotoxicity monocytes, granulocytes, most lymphocytes, leukocyte adhesion, rolling HSC NK subset homing receptor for NK cells monocytes, macrophages hemoglobin/haptoglobin scavenger receptor SIRPγ, SIRPβ2 Blood group H type 2, blood group type O Lewis Y, FUT3, LeY TN antigen Sialyl-Tn TF, Thomson Friedrenreich Ag NB1, HNA-2A FasL, CD95L VPREB1, IGVPB transferrin receptor erythrocytes, HSC CD80, CD86 CD30 CD40 BST-1 signal transduction 36 negative regulation of T cell activation T costimulation B and DC costimulation CD157 CD66a, CD66c, CD66e Glycophorin A CD150 98 CD62E, CD66a, CD66b, CD66c, CD66e CD235a costimulation, proliferation, Ig production, measles virus receptor, T and B cell activation cell adhesion, associates with integrins ADAM10 CD62E, CD66a, CD66c, CD66e CD66c CD49d/CD29, CD49d/β7 galectin-3, CD62L, C62E, CD62P galectin-3, CD62L, C62E, CD62P CD232 T subset (high upon activation), B, DC, endothelial endothelial, megakaryocytes, platelets, epithelial Tact and B Tact, macrophages, netrophils, B Tact, B, macrophages, DC CD156c CD11a/CD18, CD11b/CD18, rhinovirus C3b, C4b, CD97, echovirus, coxsackie B chondroitin sulphate proteoglycans CD62L, CD62P CD2 C8, C9 erythrocytes, endothelial, epithelial tyrosine kinase receptor monocytes, macrophages neutrophils, monocytes, granulocytes T, neutrophils, monocytes, macrophages, DC, enothelial neural precursors, fibroblasts, leukocytes CD54, CD169, selectins 35-45 75-95 33 40 32-39 CD112, CD155 Duffy, DARC tyrosine phosphatase R Type III, signaling 32 lymphocyte activation maintains cellular redox, maintains intracellular glutathione (GSH) concentrations associates with complexes of CD81, CD19 and CD21 intercellular adhesion, lymphocyte signaling, cytotoxicity, associates with CD11a/CD18 epithelial, stem cell subset, FDC, monocytes, B adhesion, signaling subset, some myelomas stem, melanomas iron transport CD234 granulocytes, monocytes, DC, Tact 80-90 69 100 C3b, C4b, measles virus receptor thrombospondin T costimulation cell morphology, adhesion and migration IL-18 insulin IGF-I, IGF-II, insulin TGFβ-LAP, plasminogen, proliferin, LIF, IGFII, HSV MHC class II TGFβ1, TGFβ3 240-260 CD155 CD156a CD156b CD22 adhesion, signal transduction, heterodimer with CD41 vitronectin, vWF, or CD51 fibrinogen and fibronectin adhesion, cell rolling, metastasis binds CD15s, CD162 adhesion, leukocyte rolling, platelet-neutrophil and platelet-mono interactions lysosomal membrane protein, expressed on cell surface after activation phagocytosis and ADCC MUC18, S-endo, MCAM, Mel-CAM Neurothelin, basoglin, EMMPRIN, BSG HPTP-eta, PTPRJ, DEP-1 SLAM, IPO-3 45 PETA-3, Tspan-24, RAPH CTLA-4 CD30L, TNFSF8 CD40L, gp39, TRAP, TNFSF5 PVR, NECL5 ADAM8, MS2 TACE/ADAM 17 adhesion, signal transduction, heterodimer with CD29 laminin, merosin or CD104 adhesion, costimulation CD11a/CD18, integrin αd/ CD18, CD209 adhesion, signal transduction, heterodimer with CD29, vitronectin, CD61, ITGB5, ITGB6, or ITGB8 vWF, fibrinogen, thrombospondin unknown signal transduction adhesion, signal transduction 228 CD150 exon A isoforms of CD45 exon B isoforms of CD45 T9, TFRC LIR-3, ILT5, HL-9, LILRB3 ILT8, LILRA6 CD139 CD148 tyrosine phosphatase, signaling CD71 CD85a CD133 64 adhesion, metastasis 50, 70, 90, 160 95 43 73 80 endothelial endothelial, melanoma, FDC, Tact Ki-24, CD27L HB15 GR6, SLAMF5 IL-1R type I, IL1R 90, 110 113-118 CD70 CD83 CD84 CD121a CDw145 CD146 28, 32 50-53 75-85 hyaluronin AIM, MLR3, VEA R2, 4F9, C33, IA4 TNFR-II, TNFRSF1B associates with CD281a to enhance IL-18 binding signaling signaling, cell proliferation, differentiation adhesion, tumor growth Band 3, SLC4A1, EPB3 90 GM-CSF adhesion, metastasis CD69 CD82 CD120b IL-18 CD233 associates with CD131, myeloid differentiation/ proliferation hematopoietic progenitor development/ differentiation associates with CD130, signal transduction, soluble form inhibits activity of LIF associates with IFN-γ AF-1, host defense hyaluronin monocytes, macrophages, neutrophils, basophils, mast, DC, myeloid progenitors, liver, B subset Tact, B, NK and granulocytes, thymocytes, platelets, Langerhans Bact and Tact, NK 60 26 50-60 associates with CD218b laminin M-CSF adhesion, metastasis 110 B7, B7-1, BB1 TAPA-1 TNFR-I, TNFRSF1A associates with IL-12 receptor β2 associates with CD124 signaling associates with CD132 and CD122 involved in inflammation CD50, CD102 IL-10 IL-10, IL-22 IL-12 IL-13 IL-13 IL-15 IL-17 CD11a/CD18 E-Cadherin monocytic differentiation/ proliferation 80-95 Ligand/Receptor T, B neurons, FDC T leukemias, neuroblastomas, brain neurons B, NK, DC, neuronal cells, monocytes, granulocytes erythrocytes CD111, CD112, CD155 G-CSF 130 Macrosialin, gp110 CD80 CD81 CD120a 300 Function putative role in sorting MHC Class II involved in innate immunity, HIV-1 binding protein signaling CD229 CD230 CD231 CD232 adhesion molecule that interacts with afadin myeloid differentiation/proliferation macrophages, monocytes, B, T, NK, neutrophils, endothelial, epithelial, fibroblasts nucleated cells mediates pro-inflammatory cellular responses, programmed cell death and anti-viral activity nucleated cells mediates pro-inflammatory cellular responses, programmed cell death and anti-viral activity T cells, thymocytes, chondrocytes, synovial IL-1 signaling cells, hepatocytes, endothelial, keratinocytes B cells, monocytes, macrophages, neutrophils IL-1 signaling, decoy receptor for IL-1b NK, T, B, monocytes, macrophages associates with CD25, CD132 and CD215, signal transduction lymphocyte subset, basophils, hematopoietic associates with CD131 progenitors, macrophages, DC, megakaryocytes mature T and B, hematopoietic precursors, associates with CD132 and IL-13Rα, T cell growth/ fibroblast, epithelial, endothelial differentiation eosinophils, basophils, B, mast associates with CD131 Bact, T, monocytes, fibroblasts associates with CD130 T, B cell precursors, thymocytes associates with CD132, B and T cell development T, B, erythroid and myeloid precursors, mast, associates with CD132, B and T cell development macrophages, epithelial Bact, plasma cells, T, monocytes, endothelial associates with CD126, LIF-R, OSMRb, signal transduction monocytes, granulocytes, early B associates with CD123, CD125, CD116, signal transduction T, B, NK, monocytes, macrophages, associates with CD25, CD122, CD124, CD127, CD129, granulocytes and CD215, signal transduction HSC and progenitors, epithelial and endothelial precursors Tact, Treg T cell activation, differentiation, apoptosis myelomonocytic, primitive B progenitors receptor tyrosine kinase, early lymph development epithelial , CNS, PNS, hematopoietic subset migration, morphological change and proliferation of different target cells CD228 MW (kD) Distribution 70-90 DCact, interdigitating DC 44 DC subset, macrophages T, B, NK, monocytes, macrophages T, B, NK, monocytes, macrophages 100 Tact, NKact 65 B, monocytes, fibroblasts, endothelial 65 B, monocytes, fibroblasts, endothelial T, B 120 B, T, NK, granulocytes, monocytes, macrophages 70 lymphocytes, neutrophils, monocytes, granulocytes, endothelial, NK, DC 70 T, NK and DC 140, 70 leukocytes, fibroblasts, endothelial, epithelial 70, 140 broad expression 250 fibroblasts, granulocytes, lymphocytes and myocytes, 90-95% intracellular 70 Tact and NK 27, 68 lymphocytes, monocytes, granulocytes, endothelial, stem 17 leukocytes, endothelial 65 T, NK, monocytes, platelets, HUVECact MF12, Melanotransferrin Ly-9 PRNP, Prion protein TSPAN7, TALLA-1 PLXNC1, VESP-R CD72, plexin B1 intercellular adhesion VE-Cadherin, Cadherin-5 putative role in cell adhesion and signaling cell adhesion immune regulation, protects fetus from maternal immune system scavenger receptor 37 90-100 CD227 CD112, CD113, CD155, nectin-4 CD111, CD113, CD155 CD144 granulocytes epithelial placental syncytiotrophoblasts, fetal liver Igb, B29 IFNGR1, IFN-γRα CD178 (FasL) CD155 CD55 intercellular adhesion hyaluronin 35 180-200 54-72 CD79b CD119 CD28, CD152 uPA, vitronectin thrombopoietin adhesion, metastasis cell adhesion 33, 45 190 Ligand/Receptor regulates megakaryocyte and platelet formation 170 granulocytes, epithelial 1 LIFR, gp190 putative role in inflammation negative regulator of TGFβ in keratinocytes ACE 90 CD68 CD118 lysosomal membrane protein CD143 cell adhesion CD66d CD66e CD66f 145 heterodimer with CD49f, cell adhesion, differentiation, metastasis cellular response to TGFβ1, adhesion, embryonic angiogenesis leukocyte adhesion, migration, costimulation lysosomal membrane protein hyaluronin granulocytes CD66c c-kit, SCFR T cell activation costimulation, adhesion, lymphocyte recirculation heterodimer with β7, lymph homing/retention adhesion, metastasis 95-100 VIM2 BGP-1, NCA-160, CEACAM1 CD67, CGM6, NCA95, CEACAM8 NCA, NCA-50/90, CEACAM6 CGM1, CEACAM3 CEA, CEACAM5 PSG1, Sp-1 CD117 cellular activation, adhesion T cell activation, adhesion isoform of CD99 cell adhesion, cellular activation CD142 phagocytosis cell adhesion CD65s CD66a 70-85 Leu-13 DNAM-1, PTA-1, TLiSA1 MUC1, EMA hyaluronin 160-180 VIM2 150 CD225 CD226 adhesion, metastasis granulocytes, monocyte subset, myeloid leukemias granulocytes, monocytes, myeloid leukemias granulocytes, epithelial CD65 CD116 M-CSFR, c-fms, CSF-1R GM-CSFRa LAG-3 GGT1 hyaluronin 72 CD64 53 83 95, 139 CD34+ subset, megakaryocytes, endothelial, epithelial testis, placenta, epithelial granulocytes, monocytes, platelets, endothelial monocytes, macrophages, osteoclasts, DC, monocytic progenitors monocytes, granulocytes, DC, endothelial, neutrophils, fibroblasts hematopoietic stem cells and progenitors, fibroblasts, mast epithelial cells in adult and embryo CD223 CD224 complex w/ NKG2, inhibits NK function apoptosis adhesion of activated T and NK adhesion, signaling adhesion, metastasis plateletsact, monocytes, macrophages, endothelial monocytes, macrophages, DC LIMP, LAMP-3, ME491 FcγRI, FcRI CD113 CD114 64-72 C1q, MBL2, SPA 180 100 hematopoietic, endothelial, soluble in plasma complement regulation CD62L 64-72 CD111 82-84 clearance of apoptotic cells, adhesion CD218b CD220 CD221 CD222 PDGFRB, PDGFRβ Thrombomodulin, THBD Tissue Factor, TF, F3 60-70 97, 107115 L-selectin, LECAM-1, 74, 95 Leu-8, LAM-1 P-selectin, PADGEM 140 PRR1, Nectin-1, PVRL1, Hve C1 PRR2, Nectin-2, HVEB PVRL3, Nectin3 G-CSFR, CFS3R CD110 putative ligand transporter α2-macroglobulin, LDLs, HSP96 choline IL18R1, IL-18Rα, IL-1Rrp IL-18Rβ, IL18RAP INSR, Insulin-R IGF-1R, IGFR IGF2R, M6P-R CD140b CD141 DAF E-selectin, ELAM-1 80 170 CD218a 180 CD55 CD62E SEMA7A, JMH Platelet activation factor, 8As, E123 TPO-R, C-MPL, CD11b/CD18 associates with FcRγ associates with FcRγ T costimulation inflammatory cell invasion, metastasis, extracellular matrix degradation granulocyte activation phagocytosis, degranulation, respiratory burst PDGFRA, PDGFRα 35-42 90-110 105 CD108 CD109 plateletsact, T, endothelial, granulocytes, macrophages, DC, metastatic tumors plateletsact, T, endothelial, granulocytes, metastatic tumors erythrocytes, lymphoblasts Tact and platelets, CD34+ subset, endothelial, HUVEC megakaryocytes, platelets, some CD34+ stem cellslow stem cell subset, macrophages, neutrophils Alternate Names LAMP3, DC-LAMP DC-SIGN IL10RA, IL-10Rα IL10RB, IL-10Rβ IL-12Rβ1, IL12RB1 IL-13Rα1, IL13RA1 IL-13Rα2, IL13RA2 IL-15Rα IL-17R CD140a MCR, Tspan-25 ICAM-1 90-120 120 endothelialact, FDC C5a receptor IgA1, IgA2 Antigen Name CD208 CD209 CDw210a CDw210b CD212 CD213a1 CD213a2 CD215 CD217 hyaluronin, osteopontin, fibronectin adhesion, migration CD53 CD54 110 55-70 19 LAMP-2 IL5RA IL6R IL7R IL9R adhesion, signal transduction, heterodimer with CD29 collagen, laminin, fibronectin T, B, NK, thymocytes, monocytes, eosinophils, adhesion, signal transduction, heterodimer with CD29 CD106, fibronectin, mast, DC or ITGB7 (integrin β7) MAdCAM-1 thymocytes, T, monocytes, platelets, and Bact adhesion, signal transduction, heterodimer with CD29 fibronectin NK, T subset, neurons, some large granular lymphocyte leukemias, myeloid leukemias NK subset, T subset, neural tissue all nucleated cells all nucleated cells CD107b CD125 CD126 CD127 CD129 B and Tlow, most adherent cell lines NCAM, Leu-19, NKH1 175-220 VCAM-1, INCAM-110 110 LAMP-1 110 140 125 110-120 CD106 CD107a IL4R adhesion, signal transduction, heterodimer with CD29 collagen, laminin memory T, thymocytes, monocytes, platelets, megakaryocytes, epithelial hematopoietic, endothelial, epidermal Langerhans plateletslow, endothelial, osteoblasts, melanomas neutrophils, monocytes, endothelial, granulocytes, NK, platelets Kp43, KLRD1 43 NK, T subset Apo-1, Fas, TNFRSF6 45 lymphocytesact, monocytes, neutrophils TACTILE 160 Tact, NK BL-KDD/F12 74, 80, 90 Tact, B, monocytes. macrophages, granulocytes, DC 4F2, FRP-1, SLC3A2 40, 80 monocytes, Tact, B, and NK MIC2, E2 32 leukocytes E2 32 T, NK, myeloid cells, thymocytes Sema4D 150 hematopoietic cells except immature BM cells, RBC and platelets V7, P126, IGSF2 120 monocytes, granulocytes, DC, Tact ICAM-2 55-65 monocytes, platelets, endothelial ITGAE, HML-1, 25, 150 intraepithelial lymph, lymph subset, activated integrin αE lymph β4 integrin 220 epithelium, Schwann cells, keratinocytes, some tumor cells Endoglin, ENG 95 endothelial, BM stroma, activated monocytes CD98 CD99 CD99R CD100 120 CD124 CD31, hyaluronic acid granulocytes, monocytes, macrophages, DC monocytes, macrophages, granulocytes, neutrophils, B subset, T subset HSC, neurons Function thought to be an inhibitory receptor Tact, Bact plasma cells, pre-B, basolateral surface of epithium, neurons B, monocytes, granulocytes, erythrocyteslow, FDC mesenchymal, fibroblasts, glial cells, monocytes, endothelial mesenchymal, endothelial, stromal cells monocytes, neutrophils, endothelial, smooth muscle cells monocytes, endothelial, keratinocytes, epithelial endothelial, epithelial, neurons, fibroblasts, macrophagesact endothelial, stem cells thymocytes, lymphocytes, monocytes, macrophages leukocytes, DC, osteoblasts, osteoclasts endothelial, monocytes, lymphocytesact 9-O-acetyl GD3 7-O-acetyl GD3 GPIIIa, Integrin β3 CD80, CD86 VCAM-1, MAdCAM-1, ECM proteins CD153 B cell adhesion, ecto-apyrase 21-28 CD60b CD60c CD61 FAP, HIV Tat, collagen CD70 B, monocytes, platelets, Tact, megakaryocytes 125 CD93 CD115 IL-2 165 25, 135 neutrophils, monocytes, granulocytes CD112 C3d, CD23, EBV BPCNeuAc IgE, CD21, CD11b, CD11c cell adhesion CD2 (low affinity), CD244 adhesion, signal transduction, heterodimer with CD29 collagen, laminin 1 Epithelial Cell CD24 CD44R CD49f CD66a CD75 CD104 CD121a CD133 CD167a CD326 (EpCAM) Stromal Cell CD10 CD34 CD157 ecto-ADP-ribosyl cyclase, cell activation, signal transduction CAMPATH-1, HES CD60a CD50, CD54, CD102, iC3b, fibrinogen 45 210 Vitronectin receptor, 24, 125 ITGAV HNK-1, Leu-7 LFA-3 Protectin, MIRL, MACIF, P-18 GD3 IgG signal transduction CD52 CD57 CD58 CD59 aggregated IgG hematopoietic cells, epithelial, endothelial, fibroblasts new designation for CDw149, similar distribution as CD47 but dimmer all leukocytes Tact, monocytes 150 70 collagen (I, IV, V), thrombospondin, oxidized LDL 24 82 115-135 CD44 variant 1-10 p70, CHTL1. CDw92, SLC44A1 C1qRp adhesion, phagocytosis GPIbb GPV Leukosialin, sialophorin, gpL115 H-CAM, Pgp-1, Hermes antigen, ECMRIII H-CAM, Pgp-1, Hermes antigen, ECMRIII CD44 variant 1-10 CD44 (v7) CD92 70 CD42c CD42d CD43 CD44 variant 1-10 600 IL3RA platelets, megakaryocytes CD44 (v5) α2MR, LRP1 CD123 145 CD44 variant 1-10 CD91 hematopoietic stem cell and neuron differentiation, adhesion, signal transduction monocytes, macrophages, neurons, fibroblasts lipid homeostasis, signal transduction C3b, C4b GPIba CD44 (v6) 25-35 adhesion, phagocytosis CD42b CD44 variant 1-10 Thy-1 60-70 75 complex w/ CD42b, c and d, platelet adhesion/ activation complex w/ CD42a, c and d, platelet adhesion/ activation complex w/ CD42a, b, d, platelet adhesion/ activation complex w/ CD42a-c inhibits adhesion CD44 (v3) CD90 IL-1R, type II IL2RB platelets, megakaryocytes CD44 variant 1-10 43 55-75 CD121b CD122 22 CD44 (v6) C5aR C5R1 FcaR, IgA-R CD62L GPIX, GP9 heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact heterogeneous expression, constitutively on epithelial, monocytes, leukocytesact all leukocytes B, Tact B, naïve T, monocytes B, T subset, monocytes, macrophages, granulocytes B, T subset, NK Tact, memory T, B subset, monocytes, macrophages, granulocytes nucleated cells CD88 CD89 stem cell marker, adhesion CD42a leukocytes, endothelial, epithelial MW (kD) Distribution 60 DC, macrophages, monocytes, pDC, endothelial NK, T subset, monocytes, macrophages, DC, B NK, T subset, monocytes, macrophages, DC, B 80 monocytes, DC, Bact and Tact 39-66 monocytes, NK, Tact, endothelial, fibroblasts CD105 adhesion platelets, megakaryocytes 80-95 CD54, CD102, iC3b, fibrinogen, CD23 CD54, iC3b, fibrinogen, CD23 polymeric or aggregated IgG 22, 125 CD44std CD50, CD54, CD102 low affinity Fc receptor, B cell activation gpIIb, ITGA2B CD44 Antigen Name Alternate Names CD85k LIR5, ILT3, HM18, LILRB4 CD85l ILT9, LILRP1 CD85m ILT10 CD86 B70, B7-2 CD87 UPA-R, PLAUR CD94 CD95 CD96 CD97 CD31, CD38 CD41 CD79a Fibroblast CD10 CD29 CD47 CD81 CD91 CD121a platelets, monocytes, macrophages, endothelial MHC class II, HIV CD72 CD166 adhesion, signal transduction 48 Other Cell-Type Antigens Erythrocyte CD45 negative CD235a monocytes, granulocytes, B, platelets, macrophages myeloid progenitors, monocytes, granulocytes, DC, macrophages hematopoietic precursors, capillary endothelial, embryonic fibroblasts erythrocytes, B, monocytes, neutrophils, eosinophils, FDC, T subset lymphocyte proliferation, apoptosis CD40 CD77 Neuron CD6 CD24 CD90 CD143 CD166 CD171 CD200 CD230 (Prion Protein) CD271 (NGFR) CD304 (Neuropilin) Bact, T and NK cells , Reed-Sternberg cells, anaplastic large cell lymphoma leukocytes, platelets, endothelial 78 lactosamines sialylated lactosamines Gb3, Pk blood groupBLA, CTH Iga, MB1 Mast Cell CD23 CD117 CD203c complex w/ CD21 and CD81, BCR co-receptor, B cell activation/ differentiation B, T subset B cell activation B, FDC, T subset complex w/ CD19 and CD81, BCR co-receptor B adhesion, B-mono, B-T interactions B, macrophagesact, eosinophils, FDC, platelets signal transduction B, granulocytes, T subset, epithelial B cell differentiation marker Tact, Bact, Treg, lymphoid progenitors forms high affinity IL-2 receptor with CD122 and CD132 mature thymocytes, Tact, B, macrophages, NK dipeptidyl peptidase, T costimulation medullary thymocytes, T, B subset, NK subset, T costimulation HSC most T, thymocytes, plasma T costimulation All leukocytes, fibroblasts, endothial, epithelial Associates with integrin α subunits (CD49a-f, C D51) ENTPD-1, gp80, EC3.6.1.5 TNFRSF5, Bp50 CD66b CD69 CD73 CD101 CD127 CD134 CD137 (4-1BB) CD152 CD154 CD197 (CCR7) CD272 (BTLA) CD278 (ICOS) CD279 (PD-1) heterodimer with CD11a, b and c, adhesion 45 CD63 CD2 CD3 CD4 CD5 CD7 CD8 CD25 CD27 CD28 CD39 CD45RA CD45RO CD62L (L-Selectin) adhesion component of low affinity Fc receptor, phagocytosis and ADCC component of low affinity Fc receptor, phagocytosis and ADCC adhesion, phagocytosis T10, ADP-ribosyl cyclase CD62P T Cell Antigens MHC class I MHC class I CD38 CD56 Stem Cell Antigens T cell differentiation, activation T cell differentiation, activation cellular adhesion and migration zinc-binding metalloproteinase, B cell development intercellular adhesion, T costimulation, heterodimer with CD18 adhesion, migration, heterodimer with CD18 B, B-CLL, HCL, B-NHL, Low on: T, granulocytes, monocytes, neutrophils, variable levels on majority of hematopoietic cells, high expression on plasma cells, B and Tact NK, macrophages, Langerhans cells, DC, Bact, Treg B, macrophages, FDC, endothelial, T subset CD49c CD11b CD16a CD25 CD56 CD57 CD69 CD94 CD58 40-52 CD49b NK Cell Antigens adhesion, T cell activation activation-dependent form of CD2 associates with TCR, TCR surface expression, signal transduction associates with TCR, TCR surface expression, signal transduction associates with TCR, TCR surface expression, signal transduction T cell differentiation, activation TCR or BCR signaling, T-B interaction T cell differentiation, costimulation T costimulation gp52-40, Tspan-26 CD44var (v7-v8) CD44 variant 1-10 Megakaryocyte/Platelet Antigens Ligand/Receptor CD1 restricted TCR CD1 restricted TCR CD1 restricted TCR CD1 restricted TCR CD37 CD39 Macrophage/Monocyte Antigens 105-120 Function lipid and glycolipid antigen presentation, w/β2m lipid and glycolipid antigen presentation, w/β2m lipid and glycolipid antigen presentation, w/β2m lipid and glycolipid antigen presentation, w/β2m lipid and glycolipid antigen presentation, w/β2m 23 B, T, NK, monocytes, DC, BM stromal cells HSC (subset of CD34+), epithelial Bact and DC subset, NK FDC, germinal centers 59 adult kidney, lung, brain, liver, neuronal progenitors adult and fetal brain, testis, eye, skeletal muscle, kidney, BM mesenchymal stem placenta and kidney; fetal lung and brain chondroitin sulfate, glycosaminoglycan, CD55 MICA, MICB, ULBP1, ULBP2, ULBP3 CD319 CD11a/CD18, reovirus PAR-3, CD49d/CD29 CD103, PS1, catenins, internalin N-Cadherin, catenins, FGFR, PS1 CD305, CD306 sialyl-Tn motifs, leptin α2,3- and α2,6-linked sialic acid α2,3- and α2,6-linked sialic acid cell division, regulation of cell growth and maturation, aFGF, bFGF formation of blood vessels cell division, regulation of cell growth and maturation, formation of blood vessels cell division, regulation of cell growth and maturation, formation of blood vessels cell division, regulation of cell growth and maturation, formation of blood vessels delivers activating signals via association with CD3ζ aFGF, bFGF aFGF, bFGF aFGF, bFGF viral HA, heparan sulfate proteoglycans delivers activating signals via association with DAP12/ viral HA KARAP delivers activating signals via association with CD3ζ membrane-associated heparan sulphate proteoglycans multi-drug resistance transporter, transport of molecules across cell membranes cell fate decisions during hematopoiesis Notch 1, Notch 2, Notch 3 SLAMF6 NK, T, B SLAMF8, BLAME monocytes, macrophages, B, DC CD354 TREM-1 monocytes, macrophages, neutrophils, granulocytes, DC, NK associates with DAP12, mediates pro-inflammatory signaling CD355 CRTAM NK act, CD8 Tact, B adhesion Necl-2 CD357 TNFRSF18, GITR, AITR Tact, Treg participates in dominant immunological selftolerance TNFSF18 CD358 TNFRSF21 hematopoietic and non-hematopoietic cells, tumor cells apoptosis APP CD360 IL-21R NK, monocytes, granulocytes, B, T associates with CD132, activation, proliferation, development, apoptosis IL-21 CD361 EVI2b, EVDB widely expressed in hematopoietic cells CD350 BM, mesenchymal stem, tumor CD50, HIV-1 gp120 CD353 CD349 185 BMP-2, BMP-4 BMP-7, GDF5 binds prostaglandin D2 leptin CD352 CD344 BM stroma, epithelial bacterial diacyllipopeptides CpG-DNA CD351 CD340 135 LPS ABCG2, BCRP, Bcrp1, MXR Jagged-1, JAG1, JAGL1, hJ1 HER2/neu, ERBB2, p185HER2 FZD4, frizzled-4, Fz-4, hFz-4, FzE4 FZD9, frizzled-9, Fz-9, hFz-9 FZD10, frizzled-10, Fz-10, hFz-10 Fca/mR, FCAMR CD339 stem cell subset (side population) LPS proposed activating receptor inhibitory receptor uptake of glycosylated antigens fusion protein in Hodgkin’s lymphoma with CD205 inhibit IFN-α/β production angiogenesis and cell survival, migration and invasion semaphorin-3A, vascular endothelial growth factor A, plexin-1 inhibitor of cell function soluble, mucosal tolerance, thought to inhibit cellular activation and inflammation regulating B cell activation, development and differentiation may have a regulatory role in normal and neoplastic B cell development may play a role in regulation of the immune system may function as an inhibitor of the B cell receptor signaling may be involved in B cell development and differentiation regulates adhesion and cell signaling, angiogenesis VEGF 30-36 135 66 30 73 dsRNA proposed activating receptor 63-75 NK lipoproteins and glycans proposed inhibitory receptor endothelial, megakaryocytes, platelets, primitive stem cell subsets monocytes, macrophages, monocyte-derived cell adhesion and migration for phagocytosis DC NK, T subset activates cytolysis and cytokine production, costimulation B subset, monocytesact, endothelial, epithelial associates with CD81 and CD9, regulates cell motility and polarity B, T, NK associates with CD81 and CD9 NK lipoprotein, lipopeptide 65 65 member of the ERBB family of receptor tyrosine kinases activation of the Wnt/β-catenin pathway Wnt, norrin activation of the Wnt/β-catenin pathway Wnt-2, Wnt-7a. activation of the Wnt/β-catenin pathway Wnt 58 IgA, IgM enhances cytokine production and proliferation CD362 Syndecan-2 granulocytes, monocytes, T subset, B subset adhesion, migration CD267 CD363 S1PR1 NK, B, T adhesion, migration, cytoskeletal organization S1P Human CD Antigens For information on CD antibody listings, fluorophore conjugations and availability from eBioscience, visit ebioscience.com/human-cd-chart Q310070h_CDAntigens Cert no. XXX-XXX-XXXX Human CD Antigens NORTH AMERICA: CUSTOMER SERVICE 888.999.1371 • info@eBioscience.com | TECHNICAL SUPPORT 888.810.6168 • tech@eBioscience.com || EUROPE: CUSTOMER SERVICE +43 1 796 40 40-304 • europe@eBioscience.com | TECHNICAL SUPPORT +43 1 796 40 40-120 • tech@eBioscience.com Customers in countries where direct sales are not available may contact their eBioscience distributor listed at www.eBioscience.com/distributors
