Neuroprosthetic Devices: The Path from Proof-of-Concept Laboratory Demonstrations to Robust Clinical Use Kip Ludwig, Ph.D. Over the last thirty years proof of concept laboratory experiments have shown that neuroprosthetic devices have great promise to reduce the burden of numerous neurological disorders. Despite this promise, relatively few neuroprosthetics have been taken beyond laboratory experiments, and even fewer have progressed beyond "first in human" feasibility studies to provide meaningful, long-term improvements in patient quality of life. For neuroprosthetic devices to truly revolutionize patient care and achieve widespread user acceptance, they must make the leap from experimental studies in the lab or clinic to robust and reliable at-home patient use. Dr. Kip Ludwig will give an overview of present trends in neurotechnology and discuss the necessary steps to translate these device concepts to meaningful improvements in patients’ health, function and quality of life. He will look at commonalities between neuroprosthetic devices that have successfully translated to at-home patient use, and outline opportunities to assist translation available at NINDS to academics and industry.