Informatics and Information Engineering CSE 5810 Prof. Steven A. Demurjian, Sr. Computer Science & Engineering Department The University of Connecticut 371 Fairfield Road, Box U-255 Storrs, CT 06269-2155 steve@engr.uconn.edu http://www.engr.uconn.edu/~steve (860) 486 - 4818 Copyright © 2008 by S. Demurjian, Storrs, CT. Portions of these slides are being used with the permission of Dr. Ling Lui, Associate Professor, College of Computing, Georgia Tech. IIE-1 Overview CSE 5810 Information Engineering Data vs. Information vs. Knowledge What is Science? What is Engineering? What is Information Consistency? Information Usage and Repositories How do we Store and Utilize Information? Sharing, Collaboration, and Security IIE-2 Information Engineering CSE 5810 Data vs. Information vs. Knowledge How do we Differentiate Between them? Where are they used in BMI? Science vs. Engineering What is each of their Roles in Informatics? How can we Engineer Information? What is their Role in BMI? What is Information Engineering? What are the Unique Challenges and Opportunities? What is Available Today and Tomorrow? IIE-3 From American Heritage CSE 5810 Data Information, esp. information organized for analysis or used as the basis for a decision. Numerical information in a form suitable for processing by computer. Information The act of informing or the condition of being informed; communication of knowledge. A non-accidental signal used as an input to a computer or communications system. Knowledge The state or fact of knowing. The sum or range of what has been perceived, discovered, or learned. Specific information about something. IIE-4 From Webster’s 9th Collegiate CSE 5810 Data Factual information (e.g. statistics) used as a basis for reasoning, discussion, or calculation. Information The communication of knowledge or intelligence Something (as a message, experimental data, or a picture) which justifies change in a construct (as a plan or theory) that represents physical or mental experience or another construct quantitative measure of the content of information Knowledge The fact or condition of having information or of being learned. The sum of what is known: the body of truth, information, and principles acquired by mankind. IIE-5 Data vs. Information vs. Knowledge CSE 5810 Overlapping Definitions Conflicting Definitions Agreement on Data Knowledge and Information - Synonyms Discussion Questions: Equivalence of Knowledge/Information? How can we Distinguish them? Do these Three Terms Cover Possibilities? IIE-6 Data, Information, and Knowledge in BMI CSE 5810 Data – Basic Level BP, Pulse, Temperature Peak Flow, Glucose Level, Biopsy Result X-Ray, MRI, Cat Scan Information - First level of Interpretation BPs, Peak Flow, Glucose over Time Interpreting Scan (Radiologist) or Biopsy Result (Oncologist) Knowledge – Applying Experience towards Diagnosis What can Low Peak Flows over Time lead to? What Next Step after Positive Scan or Biopsy? What if Glucose Level is Yo-yoing? IIE-7 From American Heritage CSE 5810 Science The observation, identification, description, experimental investigation, and theoretical explanation of natural phenomena. Methodologoical activity, discipline, or study. An activity that appears to require study & method. Knowledge, esp. gained through experience. Engineering The application of scientific and mathematical principles to practical ends such as the design, construction, and operation of efficient and economical structures, equipment, and systems. IIE-8 From Webster’s 9th Collegiate CSE 5810 Science The state of knowing: knowledge as distinguished from ignorance or misunderstanding A department of systemized knowledge as an object of study A system or method reconciling practical ends with scientific laws. Engineering The application of science and mathematics by which the properties of matter and the sources of energy in nature are made useful to people in structures, machines, products, systems, and processes. IIE-9 Science and Engineering in BMI CSE 5810 Science Data/Information Collection & Analysis to Reach Hypothesis Patients with CHF and Lipitor have Less Heart Attacks than CHF and Baby Aspirin Verify in Clinical Research/Epidemiological Study Engineering Usage of Information in Practice Apply Scientific Results to Medical Practice Image Processing used to Identify Tumors in CT and MRI Scans Transfer of Radiologists Knowledge into Computer Based (Assisted) Solution An Engineering Solution to Scientific Result IIE-10 What is Information Engineering? CSE 5810 Incorporation of an Engineering Approach and Discipline to the Generation of Information and the Promotion of the Better Use of Information and Resources Information Engineering Unifies and Combines: Software Engineering Database Engineering Security Engineering Performance Engineering Etc... Moral: Systems Cannot and Must Not be Engineered in a Vacuum! Particularly true in BMI (T1, T2, Clinical Research, and Clinical Practice) IIE-11 Information Engineering is Motivated by: CSE 5810 Realization that Management/Control of Information will be a Primary Concern as we Continue through the 1990s and into the 21st Century Currently in an Age of Information - Volume and Complexity Dependencies Critical Systems Heavily Depend on Information: Airline/Hotel/Auto Reservations Telecommunications Banking/ATMs ATM/Credit Cards at Gas Stations/Supermarkets Credit Bureaus Electronically Collect Information from Many Diverse Sources E-Tailing Medical Care/All Aspects of BMI IIE-12 Info. Engrg. - Challenge for 21st Century CSE 5810 Timely and Efficient Utilization of Information Significantly Impacts on Productivity Supports and Promotes Collaboration for Competitive Advantage Use Information in New and Different Ways Collection, Synthesis, Analyses of Information Better Understanding of Processes, Sales, Productivity, etc. Dissemination of Only Relevant/Significant Information - Reduce Overload Implications for BMI? Sharing of Results – Benefit Mankind Ability to Research on Rare Diseases Are there Unknown Isolated “Cures”? IIE-13 How is Information Engineered? CSE 5810 Careful Thought to its Definition/Purpose & Thorough Understanding of its Intended Usage/Potential Impact Insure and Maintain its Consistency Quality, Correctness, and Relevance Protect and Control its Availability (Secure Access) Who can Access What Information in Which Location and at What Time? Long-Term Persistent Storage/Recoverability Cost, Reusability, Longitudinal, and Cumulative Experience Integration of Past, Present and Future Information via Intranet and Internet Access What are Implications/Challenges for BMI? Let’s Discuss Briefly… IIE-14 Towards Information Consistency CSE 5810 Consistency of Information is Key! Consistency Gauged with respect to: Usage of Information Persistency of Information Integrity/Security of Information Allowable Values and Protection from Misuse Validity (Relevance) of Information Means Something to Someone in a Postive Way Discussion Questions: Why is Consistency Important for BMI? How is Consistency Attained for BMI? What Else Impacts Consistency BMI? IIE-15 What's Available to Support IE? CSE 5810 What Can be Provided to Make the Advanced Application Design Process: More Complete? More Robust? More Responsive? Less Error Prone? Current Choices to Support Information Engineering: Conventional Programming Languages and Data Models Object-Oriented Programming Languages Object-Oriented DBS XML and XML Databases Middleware and SOA (Web), Cloud Computing Data Mining/Warehouses IIE-16 What are Key Questions? CSE 5810 Focus on Information and its Behavior What are Different Kinds of Information? How is Information Manipulated? Is Same Information Stored in Different Ways? What are Information Interdependencies? Will Information Persist? Long-Term DB? Versions of Information? What Past Info. is Needed from Legacy DBs or Applications? Who Needs Access to What Info. When? What Information is Available Across WWW? All of these Questions Apply to BMI! IIE-17 Information Usage and Repositories CSE 5810 How do we Store and Utilize Information? Databases Data Mining What are Key Issues? Information Sharing/Data Correctness Collaboration 1. Among Providers and Researchers 2. Among Providers and Patients 3. Among Patients (Support Groups) Security 1. Control of Patient Information (De-identified) 2. Secure Exchange/Patient Ownership 3. Establish Custom Patient Controlled Groups What is the Role of Web in Informatics? IIE-18 The Role of a Database CSE 5810 Database is a Norm in Today's and Tomorrow's Applications Usage Information Tightly Linked to its Storage Integration of Database - Key Component Support Many Representations of ``Same'' Information Promotes Retrieval of Information Geared Towards User Needs and Responsibilities Gap Exists Between Standalone Programming Applications and Database Systems For BMI: Database (Data Warehouse) is a Key Feature Need for Access to Data (De-identified) Need to Share and Interact among Stakeholders IIE-19 DBMS Architecture CSE 5810 DBMS Languages Data Definition Language (DDL) Data Manipulation Language (DML) From Embedded Queries or DB Commands Within a Program “Stand-alone” Query Language Host Language: DML Specification (e.g., SQL) is Embedded in a “Host” Programming Language (e.g., Java, C++) DBMS Interfaces Menu-Based Interface Graphical Interface Forms-Based Interface Interface for DBA (DB Administrator) IIE-20 ANSI/SPARC - Three Schema Architecture CSE 5810 External Data Schema (Users’ view) Conceptual Data Schema (Logical Schema) Internal Data Schema (Physical Schema) IIE-21 How are these Used for BMI? CSE 5810 Internal Data Schema (Physical Schema) Hidden Data Representation for Storage of BMI Data in Proprietary Format Under the Control of DB System Conceptual Data Schema (Logical Schema) The Data Model for the BMI Application Access to Schema Controllable via SQL External Data Schema (Users’ view) Subsets of the Data Model for Different Users External View for Patients External View for Providers Need Ability for a Patient to Control Access to his/her Own External View Aggregate View for Population Researches IIE-22 Data Independence CSE 5810 Ability that Allows Application Programs Not Being Affected by Changes in Irrelevant Parts of the Conceptual Data Representation, Data Storage Structure and Data Access Methods Invisibility (Transparency) of the Details of Entire Database Organization, Storage Structure and Access Strategy to the Users Both Logical and Physical Recall Software Engineering Concepts: Abstraction the Details of an Application's Components Can Be Hidden, Providing a Broad Perspective on the Design Representation Independence: Changes Can Be Made to the Implementation that have No Impact on the Interface and Its Users IIE-23 Physical Data Independence CSE 5810 The Ability to Modify the Physical Data Representation Without Causing Application Programs to Be Rewritten Examples: Transparency of the Physical Storage Organization Transparency of Physical Access Paths Numeric Data Representation and Units Character Data Representation Data Coding Physical Data Structure All of these are Vital for BMI – Particularly if we Use Standard to Achieve Application Independence IIE-24 Physical Data Independence CSE 5810 Physical Data Independence is a Measure of How Much the Internal Schema Can Change Without Affecting the Application Programs In BMI – Allows us to Plug and Play Different DBMS Platforms – Extensible and Versatile Integration Physical IIE-25 Logical Data Independence CSE 5810 Transparency of the Entire Database Conceptual Organization As a Result: Transparency of Logical Access Strategy Addition of New Entities Removal of Entities Virtual (Derived) Data Items Union of Records Views Common Mechanism for Logical Data Dependency Provide Different Logical Data Contexts to Different Users Based on Their Needs Update Views vs. Read-Only Views IIE-26 Logical Data Independence CSE 5810 Logical Data Independence is a Measure of How Much the Conceptual Schema Can Change Without Affecting the Application Programs For BMI – Allows us to Separate End User Applications (Patients, Providers, etc.) from DB Logical IIE-27 Classic Information System Design CSE 5810 IIE-28 Data vs. Information CSE 5810 IIE-29 Programming Language Systems vs. DBS CSE 5810 Similarities and Differences Exist At System Level: Shared Resources vs. Shared Data Execution Granularity - Programs vs. Transactions Granularity Difference - Files vs. Instances Classic Problem of “Impedance Mismatch” Thin Layer of Overlap between PLS (C++, Java, etc.) and Relational Database System What will Future Bring? SQL3 with Object-Oriented Extensions XML Databases (Apached Xindice, Sendra, etc.) Today Tomorrow? PLS PLS RDBS XML DBS IIE-30 What is Today’s Impedance Mismatch? CSE 5810 Relational Data Organizes Information into Flat Files Relational Tables with Primary Key High Number of Tuples per Table (1000s & more) Limited Number of Tables (10-50) for Even Large Size Application Limited Linkages Among Tables (Foreign Keys) What Does BMI/PHR/EMR Require? For Each Patient, Track Multiple Dependencies Visits per Patient Tests per Patient Prescriptions per Patient Data Inherently Complex and Interdependent Flattened into Relational Format IIE-31 The Health Care Application - Classes CSE 5810 IIE-32 The Health Care Application - Classes CSE 5810 IIE-33 The Health Care Application - Classes CSE 5810 IIE-34 The Health Care Application - Relationships CSE 5810 IIE-35 How Does Mismatch Occur? CSE 5810 On Left – OO Classes Inheritance Dependencies Programmatic View C++ or Java Usage Staging from DB to OO Item(Phy_Name*, Date*, Visit_Flag, Symptom, Diagnosis, Treatment, Presc_Flag, Pre_No, Pharm_Name, Medication, Test_Flag, Test_Code, Spec_No, Status, Tech) Above – Relational Tables Stage Data from Tables into OO (e.g. Java) format Utilize JDBC What are the Implications/Impacts? IIE-36 Implications and Impact CSE 5810 Three Copies of “Same” Information in Different Database Table (Item) OO Representation – Server Side (Classes) GUI Display Client Side (html/xml) Visualization What can this Lead to? Dr. D, Jan 01, 08 Fever, Flu, Bed Rest No Scripts No Tests Item(Phy_Name*, Date*, Visit_Flag, Symptom, Diagnosis, Treatment, Presc_Flag, Pre_No, Pharm_Name, Medication, Test_Flag, Test_Code, Spec_No, Status, Tech) IIE-37 Information Sharing/Access: Potential Pitfalls CSE 5810 Another Critical Issue is Information Sharing Perception: How do I see/understand Data/Info? Differences: What is the Reality? Dealing with Information at Different Levels Syntax – Format of Information Semantics – Meaning of Information Pragmatics – Usage of Information When Unifying Databases/Information Repositories, Must Address all Three! Data Integrity and Data Security Correct and Consistent Values Assurance in All Secure Accesses For BMI – All of the Above are Critical for Correct Usage and Interpretation in All Contexts (T1, T2, …) IIE-38 Information Syntactic Considerations CSE 5810 Syntax is Structure and Format of the Information That is Needed to Support a Coalition Incorrect Structure or Format Could Result in Simple Error Message to Catastrophic Event For Sharing, Strict Formats Need to be Maintained Health Care Data Suffers from Lack of Standards Standards for Diagnosis (Insurance Industry) Emerging Standards Include: Health Level 7 (HL7) Based on XML Formats Non-Standard for Different Health Organizations, Insurers, Pharmacy Networks, etc. N*N Translations Prone to Errors! IIE-39 Information Semantics Concerns CSE 5810 Semantics (Meaning and Interpretation) NATO and US - Different Message Formats Distances (Miles vs. Kilometers) Grid Coordinates (Mils, Degrees) Maps (Grid, True, and Magnetic North) What Can Happen in Health Care Data? Possible to Confuse Dosages of Medications? Weight of Patients (Pounds vs. Kilos)? Measurement of Vital Signs? Dana Farber Chemo Death – Checks/Balances What Others are Possible? IIE-40 Syntactic & Semantic Considerations CSE 5810 What’s Available to Support Information Sharing? How do we Insure that Information can be Accurately and Precisely Exchanged? How do we Associate Semantics with the Information to be Exchanged? What Can we Do to Verify the Syntactic Exchange and that Semantics are Maintained? Can Information Exchange Facilitate Federation? Can this be Handled Dynamically? Or, Must we Statically Solve Information Sharing in Advance? IIE-41 Information Pragmatics Considerations CSE 5810 Pragmatics Require that we Totally Understand Information Usage and Information Meaning What are the Critical Information Sources? How will Information Flow Among Them? What Systems Need Access to these Sources? How will that Access be Delivered? Who (People/Roles) will Need to See What When? How will What a Person Sees Impact Other Sources? Focus on: Way that Information is Utilized and Understood in its Specific Context Can Medical Info be Misused even if Understood? IIE-42 Information Pragmatics Considerations CSE 5810 What are Pragmatics Issues re. Underinsured and Uninsured Populations in Event? How Can we Use Info Effectively if we Don’t Know if it is Complete? Has Info from All Sources Been Collected? What Happens if Same Patient in Different Repositories Can’t be Reconciled? What if Patient in Unresponsive and Can’t Supply any Info? Is Usage of Info Complicated due to Incompleteness? Multiple Locations? Or, if the Event is Major – will all Patient Populations Suffer Same Substandard Care? IIE-43 Collaboration and Security CSE 5810 Two Concepts go Hand in Hand Strong Parallels Collaboration Among Providers Among Providers and Patients Among Patients (Support Groups) Security Control of Patient Information (De-identified) Secure Exchange/Patient Ownership Establish Custom Patient Controlled Groups Let’s Explore them Both via our Semester Project Also Consider Emergent and Policy Issues IIE-44 Collaboration: Providers and Researchers CSE 5810 Providers Seeking new Treatment Plans Looking for Clinical Research Studies for Patients Looking to Communicate with Clinical Researchers Researchers Publish Evidence-Based Guidelines New Treatments Collect Data on Provider Visits Provide Forum to Discuss with Provider Allow Provider to Upload Anonymous Outcomes Also – Need to Collaborate Among Researchers of All Types (Sharepoint, WIKIs, etc.) IIE-45 Collaboration: Providers and Patients CSE 5810 Patients Open Personal Health Record to Providers Patients have Data Entry Facility for Chronic Conditions Ability to Graph and Track their Disease Education Materials also Available Providers Securely Communicate (email) with Patients (see https://www.relayhealth.com/rh/specific/patients/default.aspx) Access to Authorized Patient Data Tracking of Patients (to Reduce Office Visits) Proactive Intervention to Head off Potential Hospitalizations/Problems via Treatment Algorithms to Auto-Notify Based on Data Values IIE-46 Collaboration: Among Patients CSE 5810 Patients Provide Each with a List of Support Groups Allow them to Join Groups or Form New Groups Secure Communication via: Email Chatting Environment Link to Actual (Physical Meetings) Repository of Available Support Groups Overall: Patients can Meet other Patients with Same Issues Vital for Patients with Rare Diseases Form On-Line Communities IIE-47 Why is Collaboration Needed? CSE 5810 Emergent Need for Collaboration in Health Care: Patient Centered Medical Home (PCMH) Accountable Care Organizations (ACO) Need Coordination of Care Across Settings Recent Article Highlights Today’s Problem: “With every visit to a Boston hospital emergency room, she would meet an unfamiliar doctor and answer the same routine questions. Then, she would be whisked to another room and another doctor, and have to re-explain her situation.”1 1[http://www.boston.com/news/local/massachusetts/articles/2010/09/13/community_clinics_could_be_key_to_new_health_care_system/] IIE-48 Why is Collaboration Needed? CSE 5810 Current Situation in Health Care (IOM 2005): Limited collaboration and coordination among health care providers. Limited obligation mechanism to access to medical data and to collaborate. Limited obligation mechanism for medical treatment. Limited temporal requirements for collaboration/ coordination. Outcome (IOM 2007): High costs and inefficient patient treatment. Medical errors and increased adverse drug events. Redundancy of clinical data and medical actions. IOM = Institute of Medicine IIE-49 Why is Collaboration Needed? CSE 5810 Physician-Pharmacist Collaboration in the Management of Patients With Diabetes Resistant to Usual Care [Ramser, 2008] Team-Based Care With a Pharmacist Linked to Better Blood Pressure Control [Barclay, 2009] Physician and Pharmacist Collaboration to Improve Blood Pressure Control [Carter, 2009] The objective of each study was to evaluate if a collaborative model in community-based medical offices could improve the quality of patient treatment. The outcome was positive in each study. 50 IIE-50 Dimensions of Collaboration in PCMH CSE 5810 Coordinated Collaboration Obligated Collaboration Team-based Collaboration Collaboration Requirements in Health Care Adaptable/Dynamic Collaboration Secure Collaboration 1. How can we leverage software engineering strategies and existing models in order to address all five requirements? 2. How can we define a model that integrates all requirements? IIE-51 Dimensions of Collaboration in Health Care CSE 5810 Public Health Department Patients’ privacy preserving via restricted access to the virtual chart. Active collaboration via obligated and timely access to the virtual chart. Local EMR Access to the virtual patient chart via Health Information Exchange (HIE). Blood Tests X Ray Results Social History Scan Results Health History Med. History Coordinated collaboration via inter/intra workflow collaboration graph. Virtual Patient Chart Hospital Centers for Disease Control Medical collaboration role teams: 1.Technician Role 2.Specialist Role 3.Physician Role 4.Nurse Role 5.ER Nurse 6.ER Physician 7.Patient Role 8.Office Staff Role Legend Coordinated Collaboration in Health Care. IIE-52 Example Collaboration CSE 5810 IIE-53 Security: General Concepts CSE 5810 Authentication Proving you are who you are Signing a Message Is the Client who S/he Says they are? Authorization Granting/Denying Access Revoking Access Does the Client have Permission to do what S/he Wants? Encryption Establishing Communications Such that No One but Receiver will Get the Content of the Message Symmetric Encryption Public Key Encryption IIE-54 Key Security Issues CSE 5810 Legal and Ethical Issues Information that Must be Protected Information that Must be Accessible Policy Issues Who Can See What Information When? Applications Limits w.r.t. Data vs. Users? System Level Enforcement What is Provided by the DBMS? Programming Language? OS? Application? How Do All of the Pieces Interact? Multiple Security Levels/Organizational Enforcement Mapping Security to Organizational Hierarchy Protecting Information in Organization IIE-55 What are Key Access Control Concepts? CSE 5810 Assurance Are the Security Privileges for Each User Adequate to Support their Activities? Do the Security Privileges for Each User Meet but Not Exceed their Capabilities? Consistency Are the Defined Security Privileges for Each User Internally Consistent? Least-Privilege Principle: Just Enough Access Are the Defined Security Privileges for Related Users Globally Consistent? Mutual-Exclusion: Read for Some-Write for Others IIE-56 Available Security Approaches CSE 5810 Mandatory Access Control (MAC) Bell/Lapadula Security Model Security Classification Levels for Data Items Access Based on Security Clearance of User Role Based Access Control (RBAC) Govern Access to Information based on Role Users can Play Different Roles at Different Times Responsibilities of Users Guiding Factor Facilitate User Interactions while Simultaneously Protecting Sensitive Data Discretionary Access Control (DAC) Richer Set of Access Modes - Govern Access to Information based on User Id Discretionary Rules on Access Privileges Focused on Application Needs/Requirements IIE-57 Mandatory Security Mechanism CSE 5810 Typical Security Classification Levels for Subjects/programs and Objects/resources Top Secret (TS) and Secret (S) Confidential (C) and Unclassified (U) Rules: TS is the Highest and U is the Lowest Level TS > S > C > U Security Levels: C1 is Security Clearance Given to User U1 C2 is Security Classification Given to Object O1 U1 can Access O1 iff C1 C2 This is Referred to as the Domination of U1 Over O1 Not Prevalent in BMI – But May have Relevance IIE-58 Role Based Access Control (RBAC) CSE 5810 Focuses on Defining Roles of Typical Behavior Nurse, Nurse-Manager, Education-RN Physician, Attending-MD, Specialist Student, Faculty-Advisor, Head Focus on Duties that are Shared During Authorization of Roles to Users Establish Boundaries of Access User Steve with Role Faculty-Advisor Limited to Faculty Capabilities on Peoplesoft Only Can Manipulate His Advisees User Steve with Role Associate Head Possible Overlap in Responsibilities w/ Faculty-Advisor Other Activities not given to Faculty-Advisor Role IIE-59 Why is RBAC Needed? CSE 5810 In Health Care, different professionals (e.g., Nurses vs. Physicians vs. Administrators, etc.) Require Select Access to Sensitive Patient Data Suppose we have a Patient Access Client Lois playing the Nurse Role would be Allowed to Enter Patient History, Record Vital Signs, etc. Steve playing M.D. Role would be Allowed to do all of a Nurse plus Write Orders, Enter Scripts, etc. Vicky playing Admin Role would be Allowed to Enter Demographic/Insurance Info. Role Dictates Client Behavior Physician’s Write Scripts Nurses Enter Patient Data (Vitals + History) All Access Shared Medical Record Access is Limited Based on Role IIE-60 Discretionary Access Control CSE 5810 Discretionary Grant Privileges to Users, Including Capabilities to Access Specific Data Items in a Specific Mode Available in Most Commercial DBMSs Aspects of DAC User’s Identity Predefined Discretionary “Rules” Defined by the Security Administrator Allows User to “Delegate” Capabilities to Another User Delegate Capabilities and Ability to Delegate Role Delegation and Delegation Authority DAC Available in SQL2 IIE-61 What is Role Delegation? CSE 5810 Role Delegation, a User-to-User Relationship, Allows an Original User (OU) to Transfer Responsibility for a Particular Role to a Delegated User (DU) Two Major Types of Delegation Administratively-directed Delegation has an Administrative Infrastructure Outside the Direct Control of a User Mediates Delegation User-directed Delegation has an User (Playing a Role) Determining If and When to Delegate a Role to Another User In Both, Security Administrators Still Oversee Who Can Do What When w.r.t. Delegation IIE-62 Why is Role Delegation Important? CSE 5810 Many Different Scenarios Under Which Privileges May Want to be Passed to Other Individuals Large organizations often require delegation to meet demands on individuals in specific roles for certain periods of time True in Many Different Sectors Health Care and Financial Services Engineering and Academic Setting Example: Reda Delegates Head Role to Steve when Traveling Key Issues: Who Controls Delegation to Whom? How are Delegation Requirements Enforced? IIE-63 Coalitions for Clinical/Translational Science CSE 5810 Pfizer Bayer UConn Storrs UConn Health Center Saint DCF, Francis, DSS, etc. CCMC, … Info. Sharing - Joint R&D Support T1, T2, and Clinical Research Company and University Partnerships Collaborative Funding Opportunities Cohesive and Trusted Environment Existing Systems/Databases and New Applications How do you Protect Commercial Interests? Promote Research Advancement? Free Read for Some Data/Limited for Other? Commercialization vs. Intellectual Property? NIH FDA NSF Balancing Cooperation with Propriety IIE-64 Emergent Public Policy Issues CSE 5810 How do we Protect a Person’s DNA? Who Owns a Person’s DNA? Who Can Profit from Person’s DNA? Can Person’s DNA be Used to Deny Insurance? Employment? Etc. How do you Define Security Limitations/Access? What about i2b2 – Informatics for Integrating Biology and the Bedside (see https://www.i2b2.org/) Scalable Informatics Framework to Bridge Clinical Research Data Vast Data Banks for Basic Science Research Goal: Understand Genetic Bases of Diseases IIE-65 Emergent Public Policy Issues CSE 5810 Can DNA Repositories be Anonymously Available for Medical Research? Do Societal Needs Trump Individual Rights? Can DNA be Made Available Anonymously for Medical Research? De-identified Data Repositories Privacy Protecting Data Mining International Repository Might Allow Medical Researchers Access to Large Enough Data Set for Rare Conditions (e.g., Orphan Drug Act) Individual Rights vs. Medical Advances IIE-66 Concluding Remarks CSE 5810 We’ve looked at: Informatics Information Engineering Information Usage and Repositories Focused on Their Applicability and Relevance for BMI Likely Generated More Questions than Answers IIE-67