Bryce DA, King NJC, Graebner CF, Myers JH: Evaluation of a diagnostic reasoning program (DxR): exploring student perceptions and addressing faculty concerns. JIME 1998., 98: 451455. Eshach H, Bitterman H: From case-based reasoning to problem-based learning. Acad Med 2003, 78:491-496. Garrett BM, Callear D: The value of intelligent multimedia simulation for teaching clinical decision-making skills. Nurse Educ Today 2001, 21:382-390. Higgs J, Burn A, Jones M: Integrating clinical reasoning and evidence-based practice. AACN Clin Issues 2001, 12:482-490. Hooper RJ, O'Connor J, Cheesmar R: Clinical case-based multimedia tutorials as a solution to some problems facing medical education. Clin Chim Acta 1998, 270:65-74. Issenberg SB, McGaghie WC, Hart IR, Mayer JW, Felner JM, Petrusa ER, Waugh RA, Brown DD, Safford RR, Gessner IH, Gordon DL, Ewy GA: Simulation technology for health care professional skills training and assessment. Jama 1999, 282:861-866. Norman GR, Schmidt HG: The psychological basis of problem-based learning: a review of the evidence. Acad Med 1992, 67:557-565. Yamakawa T, Toyabe S, Cao P, Akazawa K: Web-based delivery of medical multimedia contents using an MPEG-4 system. Comput Methods Programs Biomed 2004, 75:259-264.