Latin for “poison” A virus is a particle that can only be seen with an electron microscope. 1 Day 1 Goal: The TAKS objective asks students to: compare the structures and functions of viruses to cells: 1. Compare & contrast structure of viruses and cells 2. Overview of virus structure 3. Function of viruses 2 Engage Booooo, who cares about viruses? Doing the following activity will help you understand: – how quickly viruses spread – why it’s important to prevent the spreading of viruses – THEN….you’ll want to know more about the these tiny particles that can be so deadly!!!! 3 Viruses spread! If you were a taxonomist, how would you classify these infectious particles? Predict the kingdom you believe they are assigned to. 4 Explore Analyze the following virus. Using prior knowledge of the structure of a cell, compare and contrast cells to viruses. . ligands . 5 Explain What is a Virus? A virus is a non-cellular particle made up of nucleic acid (genetic material) and protein that can invade living cells. • Cannot reproduce without a host • Capsid head filled with DNA or RNA • Covered in a sticky glycoprotein coat for specific attachment to host cell site Shapes of viruses 6 Viruses are not cells and are not madeup of cells. They don’t… Contain a nucleus or cytoplasm Eat/ metabolize nutrients Grow and develop Carry on respiration Or perform other biological functions 7 A virus is surrounded by a capsid (protein coat) which determines the shape of the virus. The capsid contains nucleic acids (either DNA or RNA). Tail fibers for attachment to host cell. 8 Viruses are classified by: type of host cell presence of DNA or RNA (retroviruses) shape: 9 Now, try to assemble a basic virus: • http://www.wisconline.com/objects/index_tj.asp?objID=MB Y101 10 Viruses differ from living cells in that all viruses — A metabolize nutrients B can be destroyed by antibiotics C have rigid cell walls D must be reproduced in living cells Remember, viruses can’t reproduce on their own. The need to use the machinery of a living cell to produce their DNA and proteins. 11 Day 2 Goal: Describe the role of viruses in causing diseases 1. Diseases viruses may cause (just a few, there are too many to cover and some still unknown) 2. How do viruses do this? 3. Treatment/ prevention 12 Can you think of some illnesses caused by viruses? Viral Infections • • • • • • • • Flu (Influenza) Common cold AIDS hepatitis chicken pox measles mumps E. Bola • • • • • • • • Pneumonia West Nile cervical cancer Warts Polio Hepatitis Rabies Smallpox 13 I still don’t get it! If a virus is not a living thing than how do they replicate? Flu Attack! How A Virus Invades Your Body : NPR 14 Wait, I’m made up of millions and millions of cells. Does that mean ANY virus can infect ANY type of cell? How do viruses recognize a target cell? Activity 15 Using the following illustration, explain the process of VIRAL REPLICATION. 2. 1. Virus recognizes and attaches to its host cell. 5. 3. 4. 16 Viruses can inject their DNA into a HOST cell, taking over its machinery, reproducing, and then killing the cell. 17 Another example of a virus reproducing Virus attaches to host cell. Virus injects its DNA Cell lyses (breaks apart) and new viruses are released Virus DNA commands host cell to make new viral parts New viral parts assembled 18 Ex of a virus, its host cell and the disease it causes: Think of a virus virus and the host cellby it attacking targets. The HIV causes AIDS Predict what would this virus if itthat did white blood cells happen called to Helper T cells not have the host cell to attach to nor invade. prevent infections in the body. 19 VIRAL DISEASES Disease Transmission Symptoms AIDS/HIV Sexual contact; contaminated blood or needles Immune system failure; fatal Common Cold Inhalation, direct contact Sinus congestion, muscle aches, cough, fever Smallpox Inhalation Blisters, lesions, fever, blindness, scars; often fatal Influenza (Flu) Inhalation Headache, muscle ache, sore throat, cough, fatigue, fever, chills Warts Direct contact Lumps on skin or mucus membranes Herpes Direct contact Open sores on mucus membranes 20 Should you ask for an antibiotic when you have the flu? NO Vaccines contain a weakened or killed virus that provides immunity to the disease. 21 Can a disease be cured? Virus No! Bacteria Yes! 1. Vaccines can prevent 1. Antibiotics kill most bacteria 2. Antibiotic resistance them. A weakened or dead strain of the virus is injected 2. Antibodies form in 710 days and will give immunity from the virus. occurs when some strong bacteria aren’t killed by antibiotics. They reproduce and are resistant. Natural Selection in action 22 1. Most viruses infect a specific kind of cell. Which of the following are infected by the human immunodeficiency virus (HIV)? A Helper T cells B Liver cells C skin cells D Red blood cells Remember, HIV infects helper-T cells (white blood cells, not red) causing the immune system to be unable to fight infection 23 2. Which of the following explains why antibiotics can treat flu-like symptoms caused by bacteria but are ineffective against flu? A Flu is a response to an antigen. B Antibiotics require time to work. C Antibiotics strengthen antibodies. D Flu is caused by a virus. Remember, the flu is caused by a virus. They can sometimes be prevented by vaccines, but cannot 24 be cured with antibiotics. Emerging Infectious Diseases Stations Activity 25