th
Seminar room, level 3, Wolfson Wohl Bldg, Garscube Campus, Glasgow G61 1QH
Monday Sept 21.
09.00 – 09.30 Coffee
09.30 – 09.40 Welcome
Session 1. 09.40 – 11.30
09.40 – 10.00 Terry Smith. Targeting key metabolic steps in trypanosomatids.
10.00 – 10.30 Fred Bringaud. De novo biosynthesis of sterols and fatty acids in the T. brucei procyclic form: carbon source preferences and metabolic flux redistributions.
10.30 – 11.00 Achim Schnauffer. Use it or lose it – function and functionality of kinetoplast DNA in
T. brucei.
11.00 - 11.20 Jurgen Haanstra. The role of fructose-1,6-bisphosphate (FBP)-activated Lactate
Dehydrogenase in the metabolism of Schistosoma mansoni.
11.20 – 11.40 Americo Ranzani. Discovery of new inhibitors of Malic Enzyme from T. cruzi.
11.40 – 12.00 Coffee
Session 2. 12.00 – 13.00
12.00 – 12.20 Darren Creek. The extent of glucose metabolism in T. brucei.
12.20 – 12.40 Snezhana Akpunarlieva. Quantitative proteomic and metabolomic analysis of
Leishmania.
12.40 – 13.10 Luisa Figueiredo. Adipose tissue is the main target organ in T. brucei infection.
13.20 – 14.00 Sandwiches
Session 3. 14.00 – 15.30
14.00 – 14.30 Christine Clayton. A repressor of procyclic-form gene expression in bloodstreamform trypanosomes.
14.30 – 14.50 Alena Zikova. In vivo and in vitro inhibition of HGPRT/XPRT enzymes by acyclic nucleoside phosphonates in T. brucei: Is purine salvage pathway a good drug target?
14.50 – 15.10 Meng Yuan. Allosteric regulation of Leishmania major fructose 1,6-bisphosphatase.
15.10 – 15.30 Hazel Hamilton. Leishmania secretomics.
15.30 – 15.50 Martin Wiese. Metabolic insights into a Leishmania kinase mutant.
15.50 – 16.10 Coffee

Session 4. 16.10 – 17.30
16.10 – 16.40 Wolfgang Schliebs. Glycosome biogenesis: new insights and drug targeting.
16.40 – 17.00 Doris Rensch. T. brucei amino acid transporters.
17.00 – 17.30 Doreen Schlisselberg. A novel role for the N-terminus of proline/alanine transporter in Leishmania (LdAAP24) in determining substrate specificity.
17.30 – 17.50 Archana Nayak. Amino acid requirements of Leishmania promastigotes.
Pub and dinner. Meet in Curlers Rest, Byres Rd. On to Café Andaluz at 19.30
Tuesday Sept 22.
09.00 – 09.30 Coffee
Session 5. 09.30 – 11.00
09.30 – 10.00 Paul Michels. Peculiarities of autophagy and autophagy-related proteins in trypanosomes.
10.00 – 10.30 Susan Wyllie. A novel nitroreductase in Leishmania that is responsible for activation of bicyclic nitroimidazoles.
10.30 - 11.00 – Nicole Ziebart. Metabolic signals and glycosomal isocitrate dehydrogenase (IDHg) control procyclic to metacyclic development of T. brucei fly stages.
11.00 – 11.30 Coffee
Session 5. 11.30 – 13.00
11.30 – 12.00 Matheus Postigo. T. cruzi and Auranofin: updates.
12.00 – 12.30 Peter Fernandes. T. cruzi phosphofructokinase.
12.30 – 12.50 James Kinkead. Characterisation of novel inhibitors against T.brucei PFK.
12.50 – 13.10 Willie Yen. Determination of the efficacy of selective phosphofructokinase-specific inhibitors on in vitro cultured T. brucei.
Close of meeting