BIOM 600: Cell Biology and Biochemistry--Fall 2015
Course Director: Richard Assoian, PhD
assoian@mail.med.upenn.edu
Office: 805 BRB II/III
Assistant Course Director: Kurt Engleka, PhD
kengleka@mail.med.upenn.edu
Office: 09-179 SCTR
Co-Directors:
Theme I:
Theme II:
Theme III:
Theme IV:
Mickey Marks, PhD (marksm@mail.med.upenn.edu)
John Weisel, PhD (weisel@mail.med.upenn.edu)
Toshinori Hoshi, PhD (hoshi@mail.med.upenn.edu)
Xiaolu Yang, PhD (xyang@mail.med.upenn.edu)
BGS Coordinator:
Colleen Dunn (898-2792; dunncoll@mail.med.upenn.edu)
TAs:
Malcolm Daniels (malcolmd@mail.med.upenn.edu)
Stephen Bart (sbart@mail.med.upenn.edu)
Lectures:
Monday, Wednesday and Friday from 10:30 AM – 11:50 AM
Austrian Auditorium
Recommended Textbook: Molecular Biology of the Cell, Eds. Alberts, et al. 6th edition
Weekly office hours/location:
Stephen Bart:
Mondays; 3-5 PM in Johnson Pavillion, Room 303
Malcolm Daniels:
Thursdays; 9:30-11:30 AM in Abramson/CHOP, 4th floor
Kurt Engleka:
Thursdays; 3-5 PM in SCTR, 09_142
Biochemistry Quiz: open note/on-line. To be completed by September 14, 2015.
REQUIRED introductory lectures (prerecorded; available via MediaSite On-Line)
Protein Purification (9-4-13)
M. Ostap
Immunological Techniques (9-6-13)
M. Marks
Basics of Protein Structure and Folding (9-9-13)
K. Ferguson
Basics of Imaging (9-12-14)
A. Stout
THEME I: COMPARTMENTATION
DATE
TOPIC
LECTURER
M Aug 31
Course introduction
Assoian
Themes in Compartmentation/Membrane
Structure
Lemmon
W Sept 2
Protein-Protein Interactions
Marmorstein
F Sept 4
Cellular Quality Control
Oliver
M Sept 7
Labor Day (no class)
W Sept 9
Protein Biogenesis & Translocation
into the Endoplasmic Reticulum
Wilusz
F Sept 11
Protein Folding & Assembly in the
Endoplasmic Reticulum
Marks
M Sept 14
Advances in Imaging
Stout
W Sept 16
Mechanisms of Vesicular Transport
Marks
F Sept 18
Golgi Function & Protein Sorting
in the Secretory Pathway
Giraudo
M Sept 21
Exocytosis & Secretion
Giraudo
W Sept 23
Endocytosis & Lysosomal Degradation
Marks
Sept 25* (ON-LINE)
Mitochondria Function & Biogenesis
Dancis
M Sept 28
Nuclear Architecture & Nucleocytoplasmic
Transport
Black
Exam review *3:30 – 5:00 pm
Engleka & TAs
W Sept 30
Exam Review
Engleka & TAs
F Oct 2
Exam 1 (10am-12pm; SCTR Auditorium)
THEME II: CELL MOTILITY AND ADHESION
M Oct 5
Actin Cytoskeleton
Dominguez
W Oct 7
Actin-Based Motility
Ostap
F Oct 9
no class (BGS anniversary celebration)
M Oct 12
Microtubules
Holzbaur
W Oct 14
Microtubule-Based Motility
Holzbaur
F Oct 16
Adhesion
Weisel
M Oct 19
Cell Extracellular Interactions
Weisel
W Oct 21
Mitosis and Cytokinesis
Bi
THEME III: MEMBRANES AND SOLUTE TRANSPORT
MediaSite On-Line
Introduction to Kinetics (Prerecorded 10-11-13) Kohli
F Oct 23
Principles of Ion Transport
Foskett
M Oct 26
Ion Channels 1
Hoshi
W Oct 28
Ion Channels 2
Hoshi
F Oct 30
Integrated Functions of Ion Channels
Foskett
M Nov 2
Membrane Problem Set
Foskett
W Nov 4
Exam Review
Engleka & TAs
F Nov 6
Exam 2 (10am-12pm; SCTR Auditorium)
THEME IV: SIGNAL TRANSDUCTION and CELL FATE
MediaSite On-Line
Introduction to Signal Transduction
Lemmon
M Nov 9
G-protein Coupled Receptors & G-proteins
Manning
W Nov 11
Small GTPases & Phosphoinositides
Chou
F Nov 13
Tyrosine Kinases & Phosphatases
Seykora
M Nov 16
Calcium Signaling & Phospolipases
Foskett
W Nov 18
Serine & Threonine Kinases
Lee
F Nov 20
Nuclear Receptor Signaling
Lazar
M Nov 23
Review
Engleka & TAs
T Nov 24
Exam 3 Part 1 (6pm – 8pm; BRB Auditorium)
W Nov 25
no class
F Nov 27
no class
M Nov 30
Signaling & Metabolism
Wellen
W Dec 2
Cell Cycle I: cyclins & CDKs
Luca
F Dec 4
Cell Cycle II: the Rb-E2F pathway
Assoian
M Dec 7
Autophagy
Cherry
W Dec 9
Apoptosis
Yang
F Dec 11
Integration of Signaling by p53
Yang
M Dec 14
Review
Engleka & TAs
W Dec 16
Exam 3 Part 2 (10am – 12pm; SCTR Auditorium)
Faculty Lecturers
Richard Assoian – assoian@mail.med.upenn.edu – 898-7157
Erfei Bi – ebi@mail.med.upenn.edu – 573-6676
Ben Black – blackbe@mail.med.upenn.edu – 898-5669
Sara Cherry – cherrys@mail.med.upenn.edu – 746-2384
Margaret Chou – mmc@mail.med.upenn.edu – 267-426-9228
Andy Dancis – adancis@mail.med.upenn.edu – 573-6275
Roberto Dominguez – droberto@mail.med.upenn.edu – 573-4559
Kevin Foskett – Foskett@mail.med.upenn.edu – 898-1354
Claudio Giraudo – giraudoc@mail.med.upenn.edu – 267-425-2124
Erika Holzbaur – holzbaur@mail.med.upenn.edu – 573-3257
Toshi Hoshi – hoshi@mail.med.upenn.edu – 573-7305
Rahul Kohli – rkohli@upenn.edu – 573-7523
Frank Lee – franklee@mail.med.upenn.edu – 898-4701
Mitch Lazar – lazar@mail.med.upenn.edu – 898-0198
Frank Luca – fluca@mail.vet.upenn.edu – 573-5664
Ronen Marmorstein – marmor@mail.med.upenn.edu– 898-7740
Dave Manning – manning@mail.med.upenn.edu – 898-1775
Mickey Marks – marksm@mail.med.upenn.edu – 898-3204
Paula Oliver – paulao@mail.med.upenn.edu – 267-426-2839
Mike Ostap – ostap@mail.med.upenn.edu – 573-9758
John Seykora – john.seykora@uphs.upenn.edu – 898-0170
Andrea Stout – astout@mail.med.upenn.edu – 573-3942
John Weisel – weisel@mail.med.upenn.edu – 898-3573
Katy Wellen – wellenk@mail.med.upenn.edu – 746-8599
Jeremy Wilusz – wilusz@mail.med.upenn.edu – 898-8862
Xiaolu Yang – xyang@mail.med.upenn.edu – 573-6739