BIOM 600: Cell Biology and Biochemistry--Fall 2014
Director:
Richard Assoian~898-7157 ~ assoian@mail.med.upenn.edu
Office: 805 BRB II/III
Co-Directors:
Theme I:
Mickey Marks ~ 215-590-3664~ marksm@mail.med.upenn.edu
Mark Lemmon ~ 898-3072 ~ mlemmon@mail.med.upenn.edu
Theme II:
John Weisel ~ 898-3573 ~ weisel@mail.med.upenn.edu
Theme III:
Toshinori Hoshi ~ 573-7305 ~ hoshi@mail.med.upenn.edu
Theme IV:
Xiaolu Yang ~ 573-6739 ~ xyang@mail.med.upenn.edu
BGS Coordinator:
Colleen Dunn ~ 898-2792 ~ dunncoll@mail.med.upenn.edu
TAs:
Kurt Engleka ~ kengleka@mail.med.upenn.edu
Megan Fisher ~ mefisher@mail.med.upenn.edu
Jamie Lemon ~ jlemon@mail.med.upenn.edu
TA Office hours/location:
Megan: Wednesday 12-2PM (Smilow Rm. 9-143)
phone: 267-426-7378
Jamie: Thursday 8:30-10:30AM (Johnson Pavilion Rm 401/Lab: Johnson Pavilion 403)
Phone: 215-573-3510
Kurt: Thursday 3-5PM (Office: Smilow Rm. 9-143)
Phone: 215-898-0252
Lectures:
Monday, Wednesday and Friday from 10:30 AM – 12:00 PM
Austrian Auditorium
Textbook:
Molecular Biology of the Cell, Eds. Alberts, et al. 5th edition
REQUIRED introductory lectures (prerecorded; available via MediaSite On-Line)
Protein Purification (9-4-13)
M. Ostap
Immunological Techniques (9-6-13)
M. Marks
Basics of Protein Structure and Folding (9-9-13)
K. Ferguson
DATE
TOPIC
LECTURER
THEME I: COMPARTMENTATION
W Sept 3
Course introduction
R. Assoian
Themes in Compartmentation
M. Marks
Membrane Structure
M. Lemmon
F Sept 5
Cellular Quality Control
P. Oliver
M Sept 8
Protein Biogenesis and Translocation
into the Endoplasmic Reticulum
J. Wilusz
W Sept 10
Protein Folding and Assembly in the
Endoplasmic Reticulum
M. Marks
DATE
TOPIC
LECTURER
F Sept 12
Imaging
A. Stout
M Sept 15
Imaging continued (10:30-11am)
A. Stout
Biochemistry Quiz (11am-12pm)
W Sept 17
Mechanisms of Vesicular Transport
M. Marks
F Sept 19
Golgi Function and Protein Sorting in
the Secretory Pathway
C. Giraudo
M Sept 22
Endocytosis and Lysosomal Degradation
M. Marks
W Sept 24
Exocytosis and Secretion
C. Giraudo
F Sept 26
Mitochondria Function and Biogenesis
A. Dancis
M Sept 29
Nuclear Architecture and Nucleocytoplasmic
Transport
B. Black
W Oct 1
Protein-Protein Interactions
R. Marmorstein
W Oct 1
Exam review *3:30 – 5:00 pm
TAs/Faculty
F Oct 3
Exam Review
TAs/Faculty
THEME II: CELL MOTILITY AND ADHESION
M Oct 6
Exam 1 (Dunlop Auditorium)
W Oct 8
Microtubules
E. Holzbaur
F Oct 10
Microtubule-Based Motility
E. Holzbaur
M Oct 13
Actin Cytoskeleton
R.Dominguez
W Oct 15
Actin-Based Motility
M. Ostap
F Oct 17
Adhesion
J. Weisel
M Oct 20
Cell Extracellular Interactions
J. Weisel
W Oct 22
Mitosis and Cytokinesis
E. Bi
THEME III: MEMBRANES AND SOLUTE TRANSPORT
MediaSite On-Line
Introduction to Kinetics (Prerecorded 10-11-13) R. Kohli
F Oct 24
Principles of Ion Transport
K. Foskett
M Oct 27
Ion Channels 1
T. Hoshi
W Oct 29
Membrane Problem Set Help Session
K. Foskett
F Oct 31
Ion Channels 2
T. Hoshi
M Nov 3
Integrated Functions of Ion Channels
K. Foskett
M Nov 3
Exam Review *3:30 – 5:00 pm
TAs/Faculty
W Nov 5
Exam Review
TAs/Faculty
F Nov 7
Exam 2 (Austrian Auditorium)
DATE
TOPIC
LECTURER
THEME IV: SIGNAL TRANSDUCTION
M Nov 10
Introduction to Signal Transduction
M. Lemmon
W Nov 12
G-Protein Coupled Receptors and G-Proteins
D. Manning
F Nov 14
Signaling by Small GTPases
M. Chou
Phosphoinositides
M Nov 17
Tyrosine Kinases and Phosphatases
M. Lemmon
W Nov 19
Calcium Signaling & Phospolipases
K. Foskett
F Nov 21
Serine and Threonine Phosphorylation
F. Lee
M Nov 24
Signaling and Metabolism
K. Wellen
W Nov 26
Autophagy
S. Cherry
F Nov 28
No Class--Thanksgiving Break
M Dec 1
Nuclear Receptor Signaling
M. Lazar
W Dec 3
Cell Cycle
F. Luca
F Dec 5
Rb-E2F/Cell cycle
R. Assoian
M Dec 8
Apoptosis
X. Yang
W Dec 10
Integration of Signaling and Disease by p53
X. Yang
F Dec 12
Exam Review
TAs/Faculty
M Dec 15
Exam Review
TAs/Faculty
W Dec 17
Exam 3 (Dunlop Auditorium)
Faculty Lecturers
Richard Assoian – assoian@mail.med.upenn.edu – 898-7157
Erfei Bi – ebi@mail.med.upenn.edu – 573-6676
Ben Black – blackbe@mail.med.upenn.edu – 898-5669
Sara Cherry – cherrys@mail.med.upenn.edu – 746-2384
Margaret Chou – mmc@mail.med.upenn.edu – 267-426-9228
Andy Dancis – adancis@mail.med.upenn.edu – 573-6275
Roberto Dominguez – droberto@mail.med.upenn.edu – 573-4559
Kevin Foskett – Foskett@mail.med.upenn.edu – 898-1354
Claudio Giraudo – giraudoc@mail.med.upenn.edu – 267-425-2124
Erika Holzbaur – holzbaur@mail.med.upenn.edu – 573-3257
Toshi Hoshi – hoshi@mail.med.upenn.edu – 573-7305
Rahul Kohli – rkohli@upenn.edu – 573-7523
Frank Lee – franklee@mail.med.upenn.edu – 898-4701
Mitch Lazar – lazar@mail.med.upenn.edu – 898-0198
Mark Lemmon – mlemmon@mail.med.upenn.edu – 898-3072
Frank Luca – fluca@mail.vet.upenn.edu – 573-5664
Ronen Marmorstein – marmor@mail.med.upenn.edu– 898-7740
Dave Manning – manning@mail.med.upenn.edu – 898-1775
Mickey Marks – marksm@mail.med.upenn.edu – 898-3204
Paula Oliver – paulao@mail.med.upenn.edu – 267-426-2839
Mike Ostap – ostap@mail.med.upenn.edu – 573-9758
Andrea Stout – astout@mail.med.upenn.edu – 573-3942
John Weisel – weisel@mail.med.upenn.edu – 898-3573
Katy Wellen – wellenk@mail.med.upenn.edu – 746-8599
Jeremy Wilusz – wilusz@mail.med.upenn.edu – 898-8862
Xiaolu Yang – xyang@mail.med.upenn.edu – 573-6739