Publications for Roger Truscott
Publications for Roger Truscott
2012
Hooi, M., Raftery, M., Truscott, R. (2012).
Age-dependent deamidation of glutamine
residues in human yS crystallin: Deamidation
and unstructured regions. Protein Science, 21(7),
1074-1079. <a
href="http://dx.doi.org/10.1002/pro.2095">[Mor
e Information]</a>
Friedrich, M., Lam, J., Truscott, R. (2012).
Degradation of an Old Human Protein:
Age-Dependent Cleavage of γS-Crystallin
Generates a Peptide that Binds to Cell
Membranes. Journal of Biological Chemistry,
287(46), 39012-39020. <a
href="http://dx.doi.org/10.1074/jbc.M112.39156
5">[More Information]</a>
Hughes, J., Deeley, J., Blanksby, S., Leisch, F.,
Ellis, S., Truscott, R., Mitchell, T. (2012).
Instability of the cellular lipidome with age. Age,
34(4), 935-947. <a
href="http://dx.doi.org/10.1007/s11357-011-929
3-6">[More Information]</a>
Truscott, R., Mizdrak, J., Friedrich, M., Hooi,
M., Lyons, B., Jamie, J., Davies, M., Wilmarth,
P., David, L. (2012). Is protein methylation in
the human lens a result of non-enzymatic
methylation by S-adenosylmethionine?
Experimental Eye Research, 99(1), 48-54. <a
href="http://dx.doi.org/10.1016/j.exer.2012.04.0
02">[More Information]</a>
Su, S., Lyons, B., Friedrich, M., McArthur, J.,
Song, X., Xavier, D., Truscott, R., Aquilina, J.
(2012). Molecular signatures of long-lived
proteins: autolytic cleavage adjacent to serine
residues. Aging Cell, 11(6), 1125-1127. <a
href="http://dx.doi.org/10.1111/j.1474-9726.201
2.00860.x">[More Information]</a>
Hooi, M., Raftery, M., Truscott, R. (2012).
Racemization of Two Proteins over Our
Lifespan: Deamidation of Asparagine 76 in yS
Crystallin Is Greater in Cataract than in Normal
Lenses across the Age Range. Investigative
Ophthalmology and Visual Science, 53(7),
3554-3561. <a
href="http://dx.doi.org/10.1167/iovs.11-9085">[
More Information]</a>
2011
Nealon, J., Blanksby, S., Donaldson, P., Truscott,
R., Mitchell, T. (2011). Fatty Acid Uptake and
Incorporation into Phospholipids in the Rat Lens.
Investigative Ophthalmology and Visual Science,
52(2), 804-809. <a
href="http://dx.doi.org/10.1167/iovs.10-5830">[
More Information]</a>
Truscott, R. (2011). Macromolecular
deterioration as the ultimate constraint on human
lifespan. Ageing Research Reviews, 10(4),
397-403. <a
href="http://dx.doi.org/10.1016/j.arr.2010.12.001
">[More Information]</a>
Hooi, M., Truscott, R. (2011). Racemisation and
human cataract. D-Ser, D-Asp/Asn and d-Thr are
higher in the lifelong proteins of cataract lenses
than in age-matched normal lenses. Age, 33(2),
131-141. <a
href="http://dx.doi.org/10.1007/s11357-010-917
1-7">[More Information]</a>
Lyons, B., Jamie, J., Truscott, R. (2011).
Spontaneous cleavage of proteins at serine
residues. International Journal of Peptide
Research and Therapeutics, 17(2), 131-135. <a
href="http://dx.doi.org/10.1007/s10989-011-925
0-3">[More Information]</a>
Su, S., McArthur, J., Truscott, R., Aquilina, J.
(2011). Truncation, cross-linking and interaction
of crystallins and intermediate filament proteins
in the aging human lens. Biochimica et
Biophysica Acta. Proteins and Proteomics, 1814
(5), 647-656. <a
href="http://dx.doi.org/10.1016/j.bbapap.2011.03
.014">[More Information]</a>
Su, S., McArthur, J., Friedrich, M., Truscott, R.,
Aquilina, J. (2011). Understanding the
α-crystallin cell membrane conjunction.
Molecular Vision, 17, 2798-2807.
2010
Hains, P., Truscott, R. (2010). Age-Dependant
Deamidation of Life-Long Proteins in the Human
Lens. Investigative Ophthalmology and Visual
Science, 51(6), 3107-3114. <a
href="http://dx.doi.org/10.1167/iovs.09-4308">[
More Information]</a>
Zhu, X., Korlimbinis, A., Truscott, R. (2010).
Age-Dependent Denaturation of Enzymes in the
Human Lens: A Paradigm for Organismic
Aging? Rejuvenation Research, 13(5), 553-560.
<a
href="http://dx.doi.org/10.1089/rej.2009.1009">[
More Information]</a>
Zhu, X., Gaus, K., Lu, Y., Magenau, A.,
Truscott, R., Mitchell, T. (2010). alpha- and
beta-Crystallins Modulate the Head Group Order
of Human Lens Membranes during Aging.
Investigative Ophthalmology and Visual Science,
51(10), 5162-5167. <a
href="http://dx.doi.org/10.1167/iovs.09-4947">[
More Information]</a>
Truscott, R. (2010). Are Ancient Proteins
Responsible for the Age-Related Decline in
Health and Fitness? Rejuvenation Research,
13(1), 83-89. <a
href="http://dx.doi.org/10.1089/rej.2009.0938">[
Publications for Roger Truscott
More Information]</a>
Ellis, S., Wu, C., Deeley, J., Zhu, X., Truscott,
R., Panhuis, M., Cooks, R., Mitchell, T.,
Blanksby, S. (2010). Imaging of Human Lens
Lipids by Desorption Electrospray Ionization
Mass Spectrometry. Journal of the American
Society for Mass Spectrometry, 21(12),
2095-2104. <a
href="http://dx.doi.org/10.1016/j.jasms.2010.09.
003">[More Information]</a>
Friedrich, M., Truscott, R. (2010). Large scale
binding of alpha-crystallin to cell membranes of
aged normal human lenses; a phenomenon that
can be induced by mild thermal stress.
Investigative Ophthalmology and Visual Science,
51(10), 5145-5152. <a
href="http://dx.doi.org/10.1167/iovs.10-5261">[
More Information]</a>
Truscott, R., Zhu, X. (2010). Presbyopia and
Cataract: A question of Heat and Time. Progress
in Retinal and Eye Research, 29(6), 487-499. <a
href="http://dx.doi.org/10.1016/j.preteyeres.2010
.05.002">[More Information]</a>
Hooi, M., Truscott, R. (2010). Racemisation and
human cataract. D: -Ser, D: -Asp/Asn and D:
-Thr are higher in the lifelong proteins of cataract
lenses than in age-matched normal lenses. Age,
33(2), 131-141. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=20686926">[More Information]</a>
Deeley, J., Hankin, J., Friedrich, M., Murphy, R.,
Truscott, R., Mitchell, T., Blanksby, S. (2010).
Sphingolipid distribution changes with age in the
human lens. Journal of Lipid Research, 51,
2753-2760. <a
href="http://dx.doi.org/10.1194/jlr.M007716">[
More Information]</a>
Truscott, R., Comte-Walters, S., Ablonczy, Z.,
Schwacke, J., Berry, Y., Korlimbinis, A.,
Friedrich, M., Schey, K. (2010). Tight Binding
of Proteins to Membranes From Older Human
Cells. Age, , 1-12. <a
href="http://dx.doi.org/10.1007/s11357-010-919
8-9">[More Information]</a>
2009
Deeley, J., Thomas, M., Truscott, R., Mitchell,
T., Blanksby, S. (2009). Identification of
Abundant Alkyl Ether Glycerophospholipids in
the Human Lens by Tandem Mass Spectrometry
Techniques. Analytical Chemistry, 81(5),
1920-1930. <a
href="http://dx.doi.org/10.1021/ac802395d">[M
ore Information]</a>
Friedrich, M., Truscott, R. (2009). Membrane
association of proteins in the aging human lens:
profound changes take place in the 5th decade of
life. Investigative Ophthalmology and Visual
Science, 50(10), 4786-4793. <a
href="http://dx.doi.org/10.1167/iovs.09-3588">[
More Information]</a>
Korlimbinis, A., Berry, Y., Thibault, D., Schey,
K., Truscott, R. (2009). Protein aging:
Truncation of aquaporin 0 in human lens regions
is a continuous age-dependent process.
Experimental Eye Research, 88, 966-973. <a
href="http://dx.doi.org/10.1016/j.exer.2008.12.0
08">[More Information]</a>
2008
Heys, K., Friedrich, M., Truscott, R. (2008). Free
and bound water in normal and cataractous
human lenses. Investigative Ophthalmology and
Visual Science, 49(5), 1991-1997. <a
href="http://dx.doi.org/10.1167/iovs.07-1151">[
More Information]</a>
Deeley, J., Mitchell, T., Wei, X., Korth, J.,
Nealon, J., Blanksby, S., Truscott, R. (2008).
Human lens lipids differ markedly from those of
commonly used experimental animals.
Biochimica et Biophysica Acta, 1781 (6-7),
288-298. <a
href="http://dx.doi.org/10.1016/j.bbalip.2008.04.
002">[More Information]</a>
Truscott, R. (2008). Presbyopia. Emerging from
a blur towards an understanding of the molecular
basis for this most common eye condition.
Experimental Eye Research, 88, 241-7. <a
href="http://dx.doi.org/10.1016/j.exer.2008.07.0
03">[More Information]</a>
Hains, P., Truscott, R. (2008). Proteome analysis
of human foetal, aged and advanced nuclear
cataract lenses. Proteomics - Clinical
Applications, 2(12), 1611-1619. <a
href="http://dx.doi.org/10.1002/prca.200800085"
>[More Information]</a>
Truscott, R., Hains, P. (2008). Proteomic
analysis of the oxidation of cysteine residues in
human age-related nuclear cataract lenses.
Biochimica et Biophysica Acta, 1784,
1959-1964. <a
href="http://dx.doi.org/10.1016/j.bbapap.2008.07
.016">[More Information]</a>
Heys, K., Truscott, R. (2008). The stiffness of
human cataract lenses is a function of both age
and the type of cataract. Experimental Eye
Research, 86(4), 701-703. <a
href="http://dx.doi.org/10.1016/j.exer.2007.12.0
09">[More Information]</a>
2007
Truscott, R. (2007). Eye Lens Proteins and
Cataracts. In Vladimir N Uversky and Anthony
L Fink (Eds.), Protein Misfolding, Aggregation,
and Conformational Diseases, (pp. 435-450).
Publications for Roger Truscott
USA: Springer.
Mizdrak, J., Hains, P., Kalinowski, D., Truscott,
R., Davies, M., Jamie, J. (2007). Novel human
lens metabolites from normal and cataractous
human lenses. Tetrahedron, 63(23), 4990-4999.
Hains, P., Truscott, R. (2007). Post-Translational
Modifications in the Nuclear Region of Young,
Aged, and Cataract Human Lenses. Journal of
Proteome Research, 6(10), 3935-3943. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17824632">[More Information]</a>
Heys, K., Friedrich, M., Truscott, R. (2007).
Presbyopia and heat: changes associated with
aging of the human lens suggest a functional role
for the small heat shock protein, alpha-crystallin,
in maintaining lens flexibility. Aging Cell, 6(6),
807-815. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17973972">[More Information]</a>
Korlimbinis, A., Aquilina, J., Truscott, R.
(2007). Protein-bound and free UV filters in
cataract lenses. The concentration of UV filters is
much lower than in normal lenses. Experimental
Eye Research, 85(2), 219-225. <a
href="http://dx.doi.org/10.1016/j.exer.2007.04.0
04">[More Information]</a>
Korlimbinis, A., Aquilina, J., Truscott, R.
(2007). Protein-bound UV filters in normal
human lenses: the concentration of bound UV
filters equals that of free UV filters in the center
of older lenses. Investigative Ophthalmology and
Visual Science, 48(4), 1718-1723. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17389504">[More Information]</a>
Parker, N., Korlimbinis, A., Jamie, J., Davies,
M., Truscott, R. (2007). Reversible binding of
kynurenine to lens proteins: potential protection
by glutathione in young lenses. Investigative
Ophthalmology and Visual Science, 48(8),
3705-3713. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17652742">[More Information]</a>
Mizdrak, J., Hains, P., Truscott, R., Jamie, J.,
Davies, M. (2007). Tryptophan-derived
ultraviolet filter compounds covalently bound to
lens proteins are photosensitizers of oxidative
damage. Free Radical Biology and Medicine,
44(6), 1108-1119. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2007.12.003">[More Information]</a>
2006
Korlimbinis, A., Hains, P., Truscott, R.,
Aquilina, J. (2006). 3-Hydroxykynurenine
oxidizes alpha-crystallin: potential role in
cataractogenesis. Biochemistry, 45(6),
1852-1860. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16460031">[More Information]</a>
Matin, A., Streete, I., Jamie, I., Truscott, R.,
Jamie, J. (2006). A fluorescence-based assay for
indoleamine 2,3-dioxygenase. Analytical
Biochemistry, 349(1), 96-102. <a
href="http://dx.doi.org/10.1016/j.ab.2005.10.039
">[More Information]</a>
Korlimbinis, A., Truscott, R. (2006).
Identification of 3-hydroxykynurenine bound to
proteins in the human lens. A possible role in
age-related nuclear cataract. Biochemistry, 45(6),
1950-1960. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16460042">[More Information]</a>
Hains, P., Mizdrak, J., Streete, I., Jamie, J.,
Truscott, R. (2006). Identification of the new UV
filter compound cysteine-l-3-hydroxykynurenine
O-beta-d-glucoside in human lenses. FEBS
Letters, 580(21), 5071-5076. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16949076">[More Information]</a>
McGinty, S., Truscott, R. (2006). Presbyopia: the
first stage of nuclear cataract? Ophthalmic
research, 38(3), 137-148. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16397406">[More Information]</a>
Hains, P., Simpanya, M., Giblin, F., Truscott, R.
(2006). UV filters in the lens of the thirteen lined
ground squirrel (Spermophilus tridecemlineatus).
Experimental Eye Research, 82(4), 730-737. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16297909">[More Information]</a>
2005
Truscott, R. (2005). Age-related nuclear
cataract-oxidation is the key. Experimental Eye
Research, 80(5), 709-725. <a
href="http://dx.doi.org/10.1016/j.exer.2004.12.0
07">[More Information]</a>
Ferry, G., Ubeaud, C., Lambert, P., Bertin, S.,
Coge, F., Chomarat, P., Delagrange, P., Serkiz,
B., Bouchet, J., Truscott, R., et al (2005).
Molecular evidence that melatonin is
enzymatically oxidized in a different manner
than tryptophan: investigations with both
indoleamine 2,3-dioxygenase and
myeloperoxidase. Biochemical Journal, 388(Part
1), 205. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
Publications for Roger Truscott
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15636586">[More Information]</a>
2004
Heys, K., Cram, S., Truscott, R. (2004). Massive
Increase In The Stiffness Of The Human Lens
Nucleus With Age: The Basis For Presbyopia?
Molecular Vision, 10(114), 956-963.
Vazquez, S., Parker, N., Sheil, M., Truscott, R.
(2004). Protein-Bound Kynurenine Decreases
With The Progression Of Age-Related Nuclear
Cataract. Investigative Ophthalmology and
Visual Science, 45(3), 879-883.
Parker, N., Jamie, J., Davies, M., Truscott, R.
(2004). Protein-Bound Kynurenine Is A
Photosensitizer Of Oxidative Damage. Free
Radical Biology and Medicine, 37(9),
1479-1489. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2004.07.015">[More Information]</a>
McNulty, R., Wang, H., Mathias, R., Ortwerth,
B., Truscott, R., Bassnett, S. (2004). Regulation
Of Tissue Oxygen Levels In The Mammalian
Lens. The Journal of Physiology, 559(3),
883-898.
2003
Sweeney, M., Garland, D., Truscott, R. (2003).
Movement of cysteine in intact monkey lenses:
the major site of entry is the germinative region.
Experimental Eye Research, 77(2), 245-251.
Hains, P., Gao, L., Truscott, R. (2003). The
photosensitiser xanthurenic acid is not present in
normal human lenses. Experimental Eye
Research, 77(5), 547-553.
2002
Hazell, L., Fu, H., Dean, R., Stocker, R.,
Truscott, R. (2002). Is hypochlorous acid
(HOCI) involved in age-related nuclear cataract?
Clinical and Experimental Optometry, 85(2),
97-100.
Terentis, A., Thomas, S., Takikawa, O.,
Littlejohn, T., Truscott, R., Armstrong, R., Yeh,
S., Stocker, R. (2002). The Heme Environment
of Recombinant Human Indoleamine
2,3-Dioxygenase: Structural Properties and
Substrate-Ligand Interactions. Journal of
Biological Chemistry, 277(18), 15788-15794.