Publications for Roger Reddel
Publications for Roger Reddel
2016
Shannon, M., Capes-Davis, A., Eggington, E.,
Georghiou, R., Huschtscha-Holliday, L., Moy,
E., Power, M., Reddel, R., Arthur, J. (2016). Is
cell culture a risky business? Risk analysis based
on scientist survey data. International Journal of
Cancer, 138(3), 664-670. <a
href="http://dx.doi.org/10.1002/ijc.29817">[Mor
e Information]</a>
Barbaro, P., Ziegler, D., Reddel, R. (2016). The
wide-ranging clinical implications of the short
telomere syndromes. Internal Medicine Journal,
46(4), 393-403. <a
href="http://dx.doi.org/10.1111/imj.12868">[Mo
re Information]</a>
2015
Killedar, A., Stutz, M., Sobinoff, A., Tomlinson,
C., Bryan, T., Beesley, J., Chenevix-Trench, G.,
Reddel, R., Pickett, H. (2015). A Common
Cancer Risk-Associated Allele in the hTERT
Locus Encodes a Dominant Negative Inhibitor of
Telomerase. PLoS Genetics, 11(6), 1-23. <a
href="http://dx.doi.org/10.1371/journal.pgen.100
5286">[More Information]</a>
Napier, C., Huschtscha-Holliday, L., Harvey, A.,
Bower, K., Noble, J., Hendrikson, E., Reddel, R.
(2015). ATRX represses alternative lengthening
of telomeres. Oncotarget, 6(18), 16543-16558.
Locke, W., Zotenko, E., Stirzaker, C., Robinson,
M., Hinshelwood, R., Stone, A., Reddel, R.,
Huschtscha, L., Clark, S. (2015). Coordinated
epigenetic remodelling of transcriptional
networks occurs during early breast
carcinogenesis. Clinical Epigenetics, 7(1), 1-15.
<a
href="http://dx.doi.org/10.1186/s13148-015-008
6-0">[More Information]</a>
Pickett, H., Reddel, R. (2015). Molecular
mechanisms of activity and derepression of
alternative lengthening of telomeres. Nature
Structural and Molecular Biology, 22(11),
875-880. <a
href="http://dx.doi.org/10.1038/nsmb.3106">[M
ore Information]</a>
Pan, J., Huang, L., Belousova, T., Lu, L., Yang,
Y., Reddel, R., Chang, A., Ju, H., DiMattia, G.,
Tong, Q., et al (2015). Stanniocalcin-1 inhibits
renal ischemia/reperfusion injury via an
AMP-activated protein kinase-dependent
pathway. Journal of the American Society of
Nephrology, 26(2), 364-378. <a
href="http://dx.doi.org/10.1681/ASN.201307070
3">[More Information]</a>
Chang, A., Doherty, J., Huschtscha-Holliday, L.,
Redvers, R., Restall, C., Reddel, R., Anderson,
R. (2015). STC1 expression is associated with
tumor growth and metastasis in breast cancer.
Clinical and Experimental Metastasis, 32(1),
15-27. <a
href="http://dx.doi.org/10.1007/s10585-014-968
7-9">[More Information]</a>
2014
Guo, Y., Kartawinata, M., Li, J., Pickett, H., Teo,
J., Kilo, T., Barbaro, P., Keating, B., Chen, Y.,
Tian, L., Al-Odaib, A., Reddel, R.,
Christodoulou, J., Bryan, T., et al (2014).
Inherited bone marrow failure associated with
germline mutation of ACD, the gene encoding
telomere protein TPP1. Blood, 124(18),
2767-2774. <a
href="http://dx.doi.org/10.1182/blood-2014-08-5
96445">[More Information]</a>
Singh, R., Kalra, R., Hasan, K., Kaul, Z.,
Cheung, C., Huschtscha, L., Reddel, R., Kaul, S.,
Wadhwa, R. (2014). Molecular characterization
of collaborator of ARF (CARF) as a DNA
damage response and cell cycle checkpoint
regulatory protein. Experimental Cell Research,
322(2), 324-334. <a
href="http://dx.doi.org/10.1016/j.yexcr.2014.01.
022">[More Information]</a>
Conomos, D., Reddel, R., Pickett, H. (2014).
NuRD-ZNF827 recruitment to telomeres creates
a molecular scaffold for homologous
recombination. Nature Structural and Molecular
Biology, 21(9), 760-770. <a
href="http://dx.doi.org/10.1038/nsmb.2877">[M
ore Information]</a>
Gupta, R., Dong, Y., Solomon, P., Wettersten,
H., Cheng, C., Min, J., Henson, J., Dogra, S.,
Hwang, S., Hammock, B., Reddel, R., et al
(2014). Synergistic tumor suppression by
combined inhibition of telomerase and
CDKN1A. Proceedings of the National Academy
of Sciences of the United States of America
(PNAS), 111(30), E3062-E3071. <a
href="http://dx.doi.org/10.1073/pnas.141137011
1">[More Information]</a>
Lee, M., Hills, M., Conomos, D., Stutz, M.,
Dagg, R., Lau, L., Reddel, R., Pickett, H. (2014).
Telomere extension by telomerase and ALT
generates variant repeats by mechanistically
distinct processes. Nucleic Acids Research,
42(3), 1733-1746. <a
href="http://dx.doi.org/10.1093/nar/gkt1117">[
More Information]</a>
Reddel, R. (2014). Telomere maintenance
mechanisms in cancer: clinical implications.
Current Pharmaceutical Design, 20(41),
6361-6374.
2013
Neumann, A., Watson, C., Noble, J., Pickett, H.,
Publications for Roger Reddel
Tam, P., Reddel, R. (2013). Alternative
lengthening of telomeres in normal mammalian
somatic cells. Genes and Devleopment, 27(1),
18-23. <a
href="http://dx.doi.org/10.1101/gad.205062.112"
>[More Information]</a>
Conomos, D., Pickett, H., Reddel, R. (2013).
Alternative lengthening of telomeres: remodeling
the telomere architecture. Frontiers in Oncology,
3, 1-7. <a
href="http://dx.doi.org/10.3389/fonc.2013.00027
">[More Information]</a>
Lau, L., Dagg, R., Henson, J., Au, A., Royds, J.,
Reddel, R. (2013). Detection of alternative
lengthening of telomeres by telomere
quantitative PCR. Nucleic Acids Research, 41(2),
1-9. <a
href="http://dx.doi.org/10.1093/nar/gks781">[M
ore Information]</a>
Bojesen, S., Pooley, K., Johnatty, S., Beesley, J.,
Michailidou, K., Tyrer, J., Edwards, S., Pickett,
H., Shen, H., Smart, C., Stutz, M., Reddel, R., et
al (2013). Multiple independent variants at the
TERT locus are associated with telomere length
and risks of breast and ovarian cancer. Nature
Genetics, 45(4), 371-384. <a
href="http://dx.doi.org/10.1038/ng.2566">[More
Information]</a>
Durukan Tolvanen, A., Westberg, J., Serlachius,
M., Chang, A., Reddel, R., Andersson, L.,
Tatlisumak, T. (2013). Stanniocalcin 1 is
important for poststroke functionality, but
dispensable for ischemic tolerance.
Neuroscience, 229, 49-54. <a
href="http://dx.doi.org/10.1016/j.neuroscience.2
012.10.062">[More Information]</a>
Pena, C., Cespedes, M., Lindh, M., Kiflemariam,
S., Mezheyeuski, A., Edqvist, P., Hagglof, C.,
Birgisson, H., Bojmar, L., Jirstrom, L., Chang,
A., Reddel, R., et al (2013). STC1 Expression By
Cancer-Associated Fibroblasts Drives Metastasis
of Colorectal Cancer. Cancer Research, 73(4),
1287-1297. <a
href="http://dx.doi.org/10.1158/0008-5472.CAN
-12-1875">[More Information]</a>
2012
Shay, J., Reddel, R., Wright, W. (2012). Cancer
and Telomeres - An ALTernative to Telomerase.
Science, 336(6087), 1388-1390. <a
href="http://dx.doi.org/10.1126/science.1222394
">[More Information]</a>
Huschtscha-Holliday, L., Napier, C., Noble, J.,
Bower, K., Au, A., Campbell, H., Braithwaite,
A., Reddel, R. (2012). Enhanced isolation of
fibroblasts from human skin explants.
BioTechniques, 53(4), 239-244. <a
href="http://dx.doi.org/10.2144/0000113939">[
More Information]</a>
Bender, H., Murchison, E., Pickett, H., Deakin,
J., Strong, M., Conlan, C., McMillan, D.,
Neumann, A., Greider, C., Hannon, G., Reddel,
R., et al (2012). Extreme telomere length
dimorphism in the Tasmanian devil and related
marsupials suggests parental control of telomere
length. PloS One, 7(9), 1-10. <a
href="http://dx.doi.org/10.1371/journal.pone.004
6195">[More Information]</a>
Kaul, Z., Cesare, A., Huschtscha, L., Neumann,
A., Reddel, R. (2012). Five dysfunctional
telomeres predict onset of senescence in human
cells. EMBO Reports, 13(1), 52-59. <a
href="http://dx.doi.org/10.1038/embor.2011.227
">[More Information]</a>
Lovejoy, C., Li, W., Reisenweber, S., Thongthip,
S., Bruno, J., De Lange, T., De, S., Petrini, J.,
Sung, P., Jasin, M., Reddel, R., et al (2012). Loss
of ATRX, Genome Instability, and an Altered
DNA Damage Response Are Hallmarks of the
Alternative Lengthening of Telomeres Pathway.
PLoS Genetics, 8(7), 1-16. <a
href="http://dx.doi.org/10.1371/journal.pgen.100
2772">[More Information]</a>
Bower, K., Napier, C., Cole, S., Dagg, R., Lau,
L., Duncan, E., Moy, E., Reddel, R. (2012). Loss
of Wild-Type ATRX Expression in Somatic Cell
Hybrids Segregates with Activation of
Alternative Lengthening of Telomeres. PloS
One, 7(11), 1-10. <a
href="http://dx.doi.org/10.1371/journal.pone.005
0062">[More Information]</a>
Reddel, R. (2012). Senescence and
immortalization. (Vol. 1, pp. 2697-2699).
Pickett, H., Reddel, R. (2012). The role of
telomere trimming in normal telomere length
dynamics. Cell Cycle, 11(7), 1309-1315. <a
href="http://dx.doi.org/10.4161/cc.19632">[Mor
e Information]</a>
Conomos, D., Stutz, M., Hills, M., Neumann, A.,
Bryan, T., Reddel, R., Pickett, H. (2012). Variant
repeats are interspersed throughout the telomeres
and recruit nuclear receptors in ALT cells. The
Journal of Cell Biology, 199(6), 893-906. <a
href="http://dx.doi.org/10.1083/jcb.201207189">
[More Information]</a>
2011
Beesley, J., Pickett, H., Johnatty, S., Dunning,
A., Chen, X., Li, J., Michailidou, K., Lu, Y.,
Rider, D., Palmieri, R., Stutz, M., Reddel, R., et
al (2011). Functional polymorphisms in the
TERT promoter are associated with risk of
serous epithelial ovarian and breast cancers. PloS
One, 6(9), 1-6. <a
href="http://dx.doi.org/10.1371/journal.pone.002
4987">[More Information]</a>
Publications for Roger Reddel
Jiang, W., Nguyen, A., Cao, Y., Chang, A.,
Reddel, R. (2011). HP1-Mediated Formation of
Alternative Lengthening of
Telomeres-Associated PML Bodies Requires
HIRA but Not ASF1a. PloS One, 6(2),
e17036-1-e17036-12. <a
href="http://dx.doi.org/10.1371/journal.pone.001
7036">[More Information]</a>
Yoon, A., Gao, R., Kaul, Z., Choi, I., Ryu, J.,
Noble, J., Kato, Y., Saito, S., Hirano, T., Ishii,
T., Reddel, R., et al (2011). MicroRNA-296 is
enriched in cancer cells and downregulates
p21WAF1 mRNA expression via interaction
with its 3' untranslated region. Nucleic Acids
Research, 39(18), 8078-8091. <a
href="http://dx.doi.org/10.1093/nar/gkr492">[M
ore Information]</a>
Pickett, H., Henson, J., Au, A., Neumann, A.,
Reddel, R. (2011). Normal mammalian cells
negatively regulate telomere length by telomere
trimming. Human Molecular Genetics, 20(23),
4684-4692. <a
href="http://dx.doi.org/10.1093/hmg/ddr402">[
More Information]</a>
Au, A., Hackl, T., Yeager, T., Cohen, S., Pass,
H., Harris, C., Reddel, R. (2011). Telomerase
activity in pleural malignant mesotheliomas.
Lung Cancer, 73(3), 283-288. <a
href="http://dx.doi.org/10.1016/j.lungcan.2010.1
2.023">[More Information]</a>
2010
Cesare, A., Reddel, R. (2010). Alternative
lengthening of telomeres: models, mechanisms
and implications. Nature reviews. Genetics,
11(5), 319-30. <a
href="http://dx.doi.org/10.1038/nrg2763">[More
Information]</a>
Henson, J., Reddel, R. (2010). Assaying and
investigating Alternative Lengthening of
Telomeres activity in human cells and cancers.
FEBS Letters, 584(17), 3800-11. <a
href="http://dx.doi.org/10.1016/j.febslet.2010.06.
009">[More Information]</a>
Capes-Davis, A., Atkin, I., Drexler, H., Kohara,
A., Macleod, R., Masters, J., Nakamura, Y.,
Reid, Y., Reddel, R., Freshney, R. (2010). Check
your cultures! A list of cross-contaminated or
misidentified cell lines. International Journal of
Cancer, 127(1), 1-8. <a
href="http://dx.doi.org/10.1002/ijc.25242">[Mor
e Information]</a>
McDonald, K., McDonnell, J., Muntoni, A.,
Henson, J., Hegi, M., von Deimling, A.,
Wheeler, H., Cook, R., Biggs, M., Little, N.,
Robinson, B., Reddel, R., et al (2010). Presence
of Alternative Lengthening of Telomeres
Mechanism in Patients With Glioblastoma
Identifies a Less Aggressive Tumor Type With
Longer Survival. Journal of Neuropathology and
Experimental Neurology, 69(7), 729-736. <a
href="http://dx.doi.org/10.1097/NEN.0b013e318
1e576cf">[More Information]</a>
Reddel, R. (2010). Senescence: an antiviral
defense that is tumor suppressive?
Carcinogenesis, 31(1), 19-26. <a
href="http://dx.doi.org/10.1093/carcin/bgp274">
[More Information]</a>
2009
Hinshelwood, R., Melki, J., Huschtscha, L., Paul,
C., Song, J., Stirzaker, C., Reddel, R., Clark, S.
(2009). Aberrant de novo methylation of the
p16INK4A CpG island is initiated post gene
silencing in association with chromatin
remodelling and mimics nucleosome positioning.
Human Molecular Genetics, 18(16), 3098-3109.
<a
href="http://dx.doi.org/10.1093/hmg/ddp251">[
More Information]</a>
Pickett, H., Reddel, R. (2009). Alternative
lengthening of telomeres in human cells. In
Keiko Hiyama (Eds.), Telomeres and
Telomerase in Cancer, (pp. 127-148). New
York: Springer.
Pickett, H., Cesare, A., Johnston, R., Neumann,
A., Reddel, R. (2009). Control of telomere length
by a trimming mechanism that involves
generation of t-circles. The EMBO Journal,
28(7), 799-809. <a
href="http://dx.doi.org/10.1038/emboj.2009.42"
>[More Information]</a>
Henson, J., Cao, Y., Huschtscha-Holliday, L.,
Chang, A., Au, A., Pickett, H., Reddel, R.
(2009). DNA C-circles are specific and
quantifiable markers of
alternative-lengthening-of-telomeres activity.
Nature Biotechnology, 27(12), 1181-1185. <a
href="http://dx.doi.org/10.1038/nbt.1587">[Mor
e Information]</a>
Graham, J., Mote, P., Salagame, U., Van Dijk, J.,
Balleine, R., Huschtscha-Holliday, L., Reddel,
R., Clarke, C. (2009). DNA replication licensing
and progenitor numbers are increased by
progesterone in normal human breast.
Endocrinology, 150(7), 3318-3326. <a
href="http://dx.doi.org/10.1210/en.2008-1630">[
More Information]</a>
Jiang, W., Zhong, Z., Nguyen, A., Henson, J.,
Toouli, C., Braithwaite, A., Reddel, R. (2009).
Induction of alternative lengthening of
telomeres-associated PML bodies by p53/p21
requires HP1 proteins. The Journal of Cell
Biology, 185(5), 797-810. <a
href="http://dx.doi.org/10.1083/jcb.200810084">
[More Information]</a>
Publications for Roger Reddel
Huschtscha-Holliday, L., Moore, J., Noble, J.,
Campbell, H., Royds, J., Braithwaite, A., Reddel,
R. (2009). Normal human mammary epithelial
cells proliferate rapidly in the presence of
elevated levels of the tumor suppressors p53 and
p21WAF1/CIP1. Journal of Cell Science,
122(16), 2989-2995. <a
href="http://dx.doi.org/10.1242/jcs.044107">[M
ore Information]</a>
Jiang, W., Henson, J., Neumann, A., Reddel, R.
(2009). Protocol III: Detection of alternative
lengthening of telomeres. In Keiko Hiyama
(Eds.), Telomeres and Telomerase in Cancer,
(pp. 351-364). New York: Springer.
Cesare, A., Kaul, Z., Cohen, S., Napier, C.,
Pickett, H., Neumann, A., Reddel, R. (2009).
Spontaneous occurrence of telomeric DNA
damage response in the absence of chromosome
fusions. Nature Structural and Molecular
Biology, 16(12), 1244-1251. <a
href="http://dx.doi.org/10.1038/nsmb.1725">[M
ore Information]</a>
Nguyen, A., Chang, A., Reddel, R. (2009).
Stanniocalcin-1 acts in a negative feedback loop
in the prosurvival ERK1/2 signaling pathway
during oxidative stress. Oncogene, 28(18),
1982-1992. <a
href="http://dx.doi.org/10.1038/onc.2009.65">[
More Information]</a>
Ng, L., Cropley, J., Pickett, H., Reddel, R., Suter,
C. (2009). Telomerase activity is associated with
an increase in DNA methylation at the proximal
subtelomere and a reduction in telomeric
transcription. Nucleic Acids Research, 37(4),
1152-1159. <a
href="http://dx.doi.org/10.1093/nar/gkn1030">[
More Information]</a>
Muntoni, A., Neumann, A., Hills, M., Reddel, R.
(2009). Telomere elongation involves
intra-molecular DNA replication in cells utilizing
alternative lengthening of telomeres. Human
Molecular Genetics, 18(6), 1017-1027. <a
href="http://dx.doi.org/10.1093/hmg/ddn436">[
More Information]</a>
Yuan, J., Yang, B., Zhong, Z., Shatts, I.,
Milyavski, M., Rotter, V., Lock, R., Reddel, R.,
Mackenzie, K. (2009). Upregulation of survivin
during immortalization of nontransformed
human fibroblasts transduced with telomerase
reverse transcriptase. Oncogene, 28(29),
2678-2689. <a
href="http://dx.doi.org/10.1038/onc.2009.136">[
More Information]</a>
2008
Cohen, S., Reddel, R. (2008). A sensitive direct
human telomerase activity assay. Nature
Methods, 5(4), 355-360. <a
href="http://dx.doi.org/10.1038/nmeth.f.209">[
More Information]</a>
Cesare, A., Reddel, R. (2008). Alternative
Lengthening of Telomeres in Mammalian Cells.
In Josef Nosek and Lubomir Tomaska (Eds.),
Origin and Evolution of Telomeres, (pp. 45-57).
United States: Landes Biosciences.
Cao, Y., Huschtscha, L., Nouwens, A., Pickett,
H., Neumann, A., Chang, A., Toouli, C., Bryan,
T., Reddel, R. (2008). Amplification of
Telomerase Reverse Transcriptase Gene in
Human Mammary Epithelial Cells with Limiting
Telomerase RNA Expression Levels. Cancer
Research, 68(9), 3115-3123. <a
href="http://dx.doi.org/10.1158/0008-5472.CAN
-07-6377">[More Information]</a>
Cao, Y., Bryan, T., Reddel, R. (2008). Increased
copy number of the TERT and TERC
telomerase subunit genes in cancer cells. Cancer
science, 99(6), 1092-1099. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18482052">[More Information]</a>
Villa, R., Daidone, M., Motta, R., Venturini, L.,
De Marco, C., Vannelli, A., Kusamura, S.,
Baratti, D., Deraco, M., Costa, A., Reddel, R., et
al (2008). Multiple mechanisms of telomere
maintenance exist and differentially affect
clinical outcome in diffuse malignant peritoneal
mesothelioma. Clinical Cancer Research,
14(13), 4134-4140. <a
href="http://dx.doi.org/10.1158/1078-0432.CCR08-0099">[More Information]</a>
Chen, Y., Campbell, H., Wiles, A., Eccles, M.,
Reddel, R., Braithwaite, A., Royds, J. (2008).
PAX8 regulates telomerase reverse transcriptase
and telomerase RNA component in glioma.
Cancer Research, 68(14), 5724-5732. <a
href="http://dx.doi.org/10.1158/0008-5472.CAN
-08-0058">[More Information]</a>
Cesare, A., Reddel, R. (2008). Telomere
uncapping and alternative lengthening of
telomeres. Mechanisms of ageing and
development, 129(1-2), 99-108. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18215414">[More Information]</a>
Chang, A., Hook, J., Lemckert, F., McDonald,
M., Nguyen, M., Hardeman, E., Little, D.,
Gunning, P., Reddel, R. (2008). The murine
stanniocalcin 2 gene is a negative regulator of
postnatal growth. Endocrinology, 149(5),
2403-2410. <a
href="http://dx.doi.org/10.1210/en.2007-1219">[
More Information]</a>
2007
Publications for Roger Reddel
Reddel, R. (2007). A SUMO ligase for ALT.
Nature Structural and Molecular Biology, 14(7),
570-571. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17611593">[More Information]</a>
lengthening of telomeres and favorable prognosis
in glioma. Cancer Research, 66(13), 6473-6476.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16818615">[More Information]</a>
Hinshelwood, R., Huschtscha, L., Melki, J.,
Stirzaker, C., Abdipranoto, A., Vissel, B.,
Ravasi, T., Wells, C., Hume, D., Reddel, R., et al
(2007). Concordant epigenetic silencing of
transforming growth factor-beta signaling
pathway genes occurs early in breast
carcinogenesis. Cancer Research, 67(24),
11517-11527. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18089780">[More Information]</a>
Neumann, A., Reddel, R. (2006). Telomerase
independent maintenance of mammalian
telomeres. In Titia De Lange, Vicki Lundblad,
Elizabeth H. Blackburn (Eds.), Telomeres and
Telomerase, (pp. 163-198). Michigan: Cold
Spring Harbor Laboratory Press.
Zhong, Z., Jiang, W., Cesare, A., Neumann, A.,
Wadhwa, R., Reddel, R. (2007). Disruption of
telomere maintenance by depletion of the
MRE11/RAD50/NBS1 complex in cells that use
alternative lengthening of telomeres. Journal of
Biological Chemistry, 282(40), 29314-29322. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17693401">[More Information]</a>
Fasching, C., Neumann, A., Muntoni, A.,
Yeager, T., Reddel, R. (2007). DNA Damage
Induces Alternative Lengthening of Telomeres
(ALT) Associated Promyelocytic Leukemia
Bodies that Preferentially Associate with Linear
Telomeric DNA. Cancer Research, 67(15),
7072-7077. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17652140">[More Information]</a>
Jiang, W., Zhong, Z., Henson, J., Reddel, R.
(2007). Identification of candidate alternative
lengthening of telomeres genes by methionine
restriction and RNA interference. Oncogene,
26(32), 4635-4647. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17297460">[More Information]</a>
Cohen, S., Graham, M., Lovrecz, G., Bache, N.,
Robinson, P., Reddel, R. (2007). Protein
composition of catalytically active human
telomerase from immortal cells. Science,
315(5820), 1850-1853. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17395830">[More Information]</a>
2006
Chen, Y., Hakin-Smith, V., Teo, M., Xinarianos,
G., Jellinek, D., Carroll, T., McDowell, D.,
MacFarlane, M., Boet, R., Baguley, B.,
Braithwaite, A., Reddel, R., et al (2006).
Association of mutant TP53 with alternative
Costa, A., Daidone, M., Daprai, L., Villa, R.,
Cantù, S., Pilotti, S., Mariani, L., Gronchi, A.,
Henson, J., Reddel, R., et al (2006). Telomere
maintenance mechanisms in liposarcomas:
association with histologic subtypes and disease
progression. Cancer Research, 66(17),
8918-8924. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16951210">[More Information]</a>
Wadhwa, R., Takano, S., Kaur, K., Deocaris, C.,
Pereira-Smith, O., Reddel, R., Kaul, S. (2006).
Upregulation of mortalin/mthsp70/Grp75
contributes to human carcinogenesis.
International Journal of Cancer, 118(12),
2973-2980. <a
href="http://dx.doi.org/10.1002/ijc.21773">[Mor
e Information]</a>
2005
Henson, J., Hannay, J., McCarthy, S., Royds, J.,
Yeager, T., Robinson, R., Wharton, S., Jellinek,
D., Arbuckle, S., Yoo, J., Robinson, B., Learoyd,
D., Reddel, R., et al (2005). A robust assay for
alternative lengthening of telomeres in tumors
shows the significance of alternative lengthening
of telomeres in sarcomas and astrocytomas.
Clinical Cancer Research, 11(1), 217-225. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15671549">[More Information]</a>
Jeyapalan, J., Varley, H., Foxon, J., Pollock, R.,
Jeffreys, A., Henson, J., Reddel, R., Royle, N.
(2005). Activation of the ALT pathway for
telomere maintenance can affect other sequences
in the human genome. Human Molecular
Genetics, 14(13), 1785-1794. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15888482">[More Information]</a>
Moran-Jones, K., Wayman, L., Kennedy, D.,
Reddel, R., Sara, S., Snee, M., Smith, R. (2005).
hnRNP A2, a potential ssDNA/RNA molecular
adapter at the telomere. Nucleic Acids Research,
33(2), 486-496. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
Publications for Roger Reddel
&list_uids=15659580">[More Information]</a>
836-838.
Jiang, W., Zhong, Z., Henson, J., Neumann, A.,
Chang, A., Reddel, R. (2005). Suppression of
Alternative Lengthening of Telomeres by
Sp100-Mediated Sequestration of the
Reddel, R. (2003). Alternative lengthening of
telomeres, telomerase and cancer. Cancer
Letters, 194(2), 155-162.
MRE11/RAD50/NBS1 Complex. Molecular and
Cellular Biology, 25(7), 2708-2721. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15767676">[More Information]</a>
Fasching, C., Bower, K., Reddel, R. (2005).
Telomerase-Independent Telomere Length
Maintenance in the Absence of Alternative
Lengthening of Telomeres–Associated
Promyelocytic Leukemia Bodies. Cancer
Research, 65(7), 2722-2729. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15805271">[More Information]</a>
Muntoni, A., Reddel, R. (2005). The first
molecular details of ALT in human tumor cells.
Human Molecular Genetics, 14(Review Issue 2),
R191-R196. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16244317">[More Information]</a>
Chang, A., Cha, J., Koentgen, F., Reddel, R.
(2005). The murine stanniocalcin 1 gene is not
essential for growth and development. Molecular
and Cellular Biology, 25(23), 10604-10610. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16287871">[More Information]</a>
2004
Noble, J., Zhong, Z., Neumann, A., Melki, J.,
Clark, S., Reddel, R. (2004). Alterations In The
P16(Ink4A) And P53 Tumor Suppressor Genes
Of Htert-Immortalized Human Fibroblasts.
Oncogene, 23(17), 3116-3121.
Londono-Vallejo, J., Der-Sarkissian, H., Cazes,
L., Bacchetti, S., Reddel, R. (2004). Alternative
Lengthening Of Telomeres Is Characterized By
High Rates Of Telomeric Exchange. Cancer
Research, 64(7), 2324-2327.
Colgin, L., Reddel, R. (2004). Telomere Biology:
A New Player In The Dispatch End Zone.
Current Biology, 14(20), R901-R902. <a
href="http://dx.doi.org/10.1016/j.cub.2004.09.07
5">[More Information]</a>
2003
Hakin-Smith, V., Jellinek, D., Levy, D., Carroll,
T., Teo, M., Timperley, W., McKay, M., Reddel,
R., Royds, J. (2003). Alternative lengthening of
telomeres and survival in patients with
glioblastoma multiforme. The Lancet, 361(9360),
Reddel, R., Bryan, T. (2003). Alternative
lengthening of telomeres: dangerous road less
travelled. The Lancet, 361(9372), 1840-1841.
Colgin, L., Baran, K., Baumann, P., Cech, T.,
Reddel, R. (2003). Human POT1 facilitates
telomere elongation by telomerase. Current
Biology, 13(11), 942-946.
Chang, A., Jellinek, D., Reddel, R. (2003).
Mammalian stanniocalcins and cancer.
Endocrine-Related Cancer, 10(3), 359-373.
Kaul, S., Yaguchi, T., Taira, K., Reddel, R.,
Wadhwa, R. (2003). Overexpressed mortalin
(mot-2)/mthsp70/GRP75 and hTERT cooperate
to extend the in vitro lifespan of human
fibroblasts. Experimental Cell Research, 286(1),
96-101.
Toouli, C., Reddel, R. (2003). Telomeres and
cellular ageing. In S.C. Kaul and R. Wadhwa
(Eds.), Aging of Cells In and Outside the Body,
(pp. 171-205). US: Kluwer Academic Publishers.
2002
Wadhwa, R., Sugihara, T., Hasan, M., Taira, K.,
Reddel, R., Kaul, S. (2002). A Major Functional
Difference between the mouse and Human ARF
Tumor Suppressor proteins. Journal of
Biological Chemistry, 277(39), 36665-36670.
Henson, J., Neumann, A., Yeager, T., Reddel, R.
(2002). Alternative lengthening of telomeres in
mammalian cells. Oncogene, 21(4), 598-610.
Toouli, C., Huschtscha, L., Neumann, A., Noble,
J., Colgin, L., Hukku, B., Reddel, R. (2002).
Comparison of human mammary epithelial cells
immortalized by simian virus 40 T-antigen or by
the telomerase catalytic subunit. Oncogene,
21(1), 128-139.
Wadhwa, R., Yaguchi, T., Hasan, M., Mitsui, Y.,
Reddel, R., Kaul, S. (2002). Hsp70 Family
Member, mot-2/mthsp70/GRP75, binds to the
Cytoplasmic Sequestration Domain of the P53
Gene. Experimental Cell Research, 274(2),
246-253. <a
href="http://dx.doi.org/10.1006/excr.2002.5468"
>[More Information]</a>
Varley, H., Pickett, H., Foxon, J., Reddel, R.,
Royle, N. (2002). Molecular characterisation of
inter-telomere and intra-telomere mutations in
human ALT cells. Nature Genetics, 30(3),
301-305.
Wadhwa, R., Colgin, L., Yaguchi, T., Taira, K.,
Reddel, R., Kaul, S. (2002). Rhodacyanine Dye
MKT-077 Inhibits in Vito Telomerase Assay but
Publications for Roger Reddel
has no detectable effects on Telomerase activity
in vivo. Cancer Research, 62(15), 4434-4438.
Bouras, T., Southey, M., Chang, A., Reddel, R.,
Willhite, D., Glynne, R., Henderson, M., Armes,
J., Venter, D. (2002). Stanniocalcin 2 is an
estorgen-responsive gene coexpressed with the
estrogen receptor in human breast cancer.
Cancer Research, 62(5), 1289-1295.
Neumann, A., Reddel, R. (2002). Telomere
maintenance and cancer - look, no Telomerase.
Nature Reviews Cancer, 2(11), 879-884.
Fasching, C., Reddel, R. (2002). Telomere
maintenance in human cell lines and tumors
without telomerase. In Guido Krupp and Reza
Parwaresch (Eds.), Telomeres and telomerases:
Cancer and Biology, (pp. 359-373). Georgetown,
Texas, USA: Landes Biosciences.
2001
Reddel, R., Bryan, T., Colgin, L., Perrem, K.,
Yeager, T. (2001). Alternative lengthening of
telomeres in human cells. Radiation Research,
155(1), 194-200. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=11121234">[More Information]</a>
Reddel, R. (2001). An alternative lifestyle for
immortalized oral keratinocytes. Journal of
Clinical Investigation, 108, 665-667.
Reddel, R., Kaul, S., Mitsui,, Y., Wadhwa, R.
(2001). An N-Terminal Region of Mot-2 Binds
to p53 In Vitro. Neoplasia (Spanish Edition):
oncologia multidisciplinaria, 3, 110-114.
Perrem, K., Colgin, L., Neumann,, A., Yeager,
T., Reddel, R. (2001). Coexistence of Alternative
Lengthening of Telomeres and Telomerase in
hTERT-Transfected GM847 Cells. Molecular
and Cellular Biology, 21, 3862-3875.
Reddel, R., Huschtscha, L., Neumann,, A.,
Noble,, J. (2001). Effects of Simian Virus 40
T-Antigens on Normal Human Mammary
Epithelial Cells Reveal Evidence for
Spontaneous Alterations in Addition to Loss of
P16INK4a Expression. Experimental Cell
Research, 265, 125-134.
Reddel, R., Sugihara, T., Kaul, S., Kato, J.,
Nomura, H., Wadhwa, R. (2001). Pex19p
Dampens the p19ARF-p53-p21WAF1 Tumor
Suppressor Pathway. Journal of Biological
Chemistry, 276, 18649-18652.
Reddel, R., Szutorisz, H., Palmqvist, R., Roos,
G., Stenling,, R., Schorderet, D., Linger,, J.,
Nabholz,, M. (2001). Rearrangements of
minisatelites in the human telomerase reverse
transcriptase gene are not correlated with its
expression in colon carcinomas. Oncogene, 20,
2600-2605.