Publications for Philip O'Connell 2016

Publications for Philip O'Connell

2016

Cozzi, E., Tonjes, R., Gianello, P., Buhler, L.,

Rayat, G., Matsumoto, S., Park, C., Kwon, I.,

Wang, W., O'Connell, P., et al (2016). First update of the International Xenotransplantation

Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation.

Xenotransplantation , 23(1), 14-24. <a href="http://dx.doi.org/10.1111/xen.12222">[Mo re Information]</a>

Hering, B., O'Connell, P. (2016). First update of the International Xenotransplantation

Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes - Chapter 6: Patient selection for pilot clinical trials of islet xenotransplantation. Xenotransplantation , 23(1),

60-76. <a href="http://dx.doi.org/10.1111/xen.12228">[Mo re Information]</a>

Joglekar, M., Trivedi, P., Kay, T., Hawthorne,

W., O'Connell, P., Jenkins, A., Hardikar, A.,

Thomas, H. (2016). Human islet cells are killed by BID-independent mechanisms in response to

FAS ligand. Apoptosis , 21(4), 379-389. <a href="http://dx.doi.org/10.1007/s10495-016-121

2-y">[More Information]</a>

Bartlett, S., Markmann, J., Johnson, P.,

Korsgren, O., Hering, B., Scharp, D., Kay, T.,

Bromberg, J., Odorico, J., Weir, G., O'Connell,

P., et al (2016). Report from IPITA-TTS opinion leaders meeting on the future of β-cell replacement. Transplantation , 100, S1-S44. <a href="http://dx.doi.org/10.1097/TP.00000000000

01055">[More Information]</a>

O'Connell, P., Yi, S. (2016). Response to comment on Yi et al.: Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes

2012; 61: 1180-1191. Diabetes , 65(2), e9-e10. <a href="http://dx.doi.org/10.2337/dbi15-0042">[M ore Information]</a>

2015

Wong, N., O'Connell, P., Chapman, J.,

Nankivell, B., Kable, K., Webster, A., Wong, G.

(2015). Bortezomib in ABO-incompatible kidney transplant desensitization: A case report.

Nephrology , 20(Suppl 1), 22-24. <a href="http://dx.doi.org/10.1111/nep.12424">[Mo re Information]</a>

Nankivell, B., Renthawa, J., Jeoffreys, N., Kable,

Publications for Philip O'Connell

K., O'Connell, P., Chapman, J., Wong, G.,

Sharma, R. (2015). Clinical Utility of Urinary

Cytology to Detect BK Viral Nephropathy.

Transplantation , 99(8), 1715-1722. <a href="http://dx.doi.org/10.1097/TP.00000000000


Stewart, J., Tarantal, A., Hawthorne, W.,

Salvaris, E., O'Connell, P., Nottle, M., D'Apice,

A., Cowan, P., Kearns-Jonker, M. (2015).

Clonidine inhibits anti-non-Gal IgM xenoantibody elicited in multiple pig-to-primate models. Xenotransplantation , 22(6), 413-426. <a href="http://dx.doi.org/10.1111/xen.12199">[Mo re Information]</a>

Vincenti, F., Silva, H., Busque, S., O'Connell, P.,

Russ, G., Budde, K., Yoshida, A., Tortorici, M.,

Lamba, M., Lawendy, N., et al (2015).

Evaluation of the effect of tofacitinib exposure on outcomes in kidney transplant patients.

American Journal of Transplantation , 15(6),

1644-1653. <a href="http://dx.doi.org/10.1111/ajt.13181">[Mor e Information]</a>

Menon, M., Chuang, P., Li, Z., Wei, C., Zhang,

W., Luan, Y., Yi, Z., Xiong, H., Woytovich, C.,

Greene, I., O'Connell, P., et al (2015). Intronic locus determines SHROOM3 expression and potentiates renal allograft fibrosis. Journal of

Clinical Investigation , 125(1), 208-221. <a href="http://dx.doi.org/10.1172/JCI76902">[Mor e Information]</a>

Marathe, C., Drogemuller, C., Marathe, J.,

Loudavaris, T., Hawthorne, W., O'Connell, P.,

Radford, T., Kay, T., Horowitz, M., Coates, P., et al (2015). Islet Cell Transplantation in Australia:

Screening, Remote Transplantation, and Incretin

Hormone Secretion in Insulin Independent

Patients. Hormone And Metabolic Research ,

47(1), 16-23. <a href="http://dx.doi.org/10.1055/s-0034-1389941

">[More Information]</a>

Jimenez, E., Davies, S., Phillips, P., O'Connell,

P., Hawthorne, W. (2015). Long-term cultured neonatal islet cell clusters demonstrate better outcomes for reversal of diabetes: In vivo and molecular profiles. Xenotransplantation , 22(2),

114-123. <a href="http://dx.doi.org/10.1111/xen.12151">[Mo re Information]</a>

Pathiraja, V., Kuehlich, J., Campbell, P.,

Krishnamurthy, B., Loudovaris, T., Coates, P.,

Brodnicki, T., O'Connell, P., Kedzierska, K.,

Rodda, C., et al (2015). Proinsulin specific,

HLA-DQ8 and HLA-DQ8 transdimer restricted,

CD4+ T cells infiltrate the islets in type 1 diabetes. Diabetes , 64(1), 172-182. <a href="http://dx.doi.org/10.2337/db14-0858">[M ore Information]</a>

Chung, H., Lam, V., Yuen, L., Ryan, B.,

O'Connell, P., Chapman, J., Hawthorne, W.,

Pleass, H. (2015). Renal transplantation: better fat than thin. Journal of Surgical Research ,

194(2), 644-652. <a href="http://dx.doi.org/10.1016/j.jss.2013.12.027

">[More Information]</a>

2014

Huang, J., Zheng, S., Liu, Y., Wang, H.,

Chapman, J., O'Connell, P., Millis, M., Fung, J.,

Delmonico, F. (2014). China organ donation and transplantation update: the Hangzhou Resolution.

Hepatobiliary & Pancreatic Diseases

International , 13(2), 122-124. <a href="http://dx.doi.org/10.1016/S1499-3872(14)

60022-9">[More Information]</a>

Hawthorne, W., Salvaris, E., Phillips, P.,

Hawkes, J., Liuwantara, D., Burns, H., Barlow,

H., Stewart, A., Peirce, S., Hu, M., O'Connell, P., et al (2014). Control of IBMIR in Neonatal

Porcine Islet Xenotransplantation in Baboons.



Jin, X., Wang, Y., Hawthorne, W., Hu, M., Yi,

S., O'Connell, P. (2014). Enhanced Suppression of the Xenogeneic T-Cell Response in Vitro by

Xenoantigen Stimulated and Expanded

Regulatory T Cells. Transplantation , 97(1),

30-38. <a href="http://dx.doi.org/10.1097/TP.0b013e3182a

860fa">[More Information]</a>

Balamurugan, A., Naziruddin, B., Lockridge, A.,

Tiwari, M., Matsumoto, S., Papas, K., Trieger,

M., Rainis, H., Kin, T., Kay, T., O'Connell, P., et al (2014). Islet Product Characteristics and

Factors Related to Successful Human Islet

Transplantation From the Collaborative Islet

Transplant Registry (CITR) 1999-2010.



Delmonico, F., Chapman, J., Fung, J., Capron,

A., Danovitch, G., Levin, A., Busuttil, R.,

O'Connell, P. (2014). Open letter to Xi Jinping, president of the People's Republic of China:

China's fight against corruption in organ transplantation. Transplantation , 97(8), 795-796.

<a href="http://dx.doi.org/10.1097/TP.00000000000


Delmonico, F., Capron, A., Danovitch, G.,

Levin, A., O'Connell, P. (2014). Organ transplantation in China-not yet a new era. The

Lancet , 384(9945), 741. <a href="http://dx.doi.org/10.1016/S0140-6736(14)



Brady, J., Harrison, L., Goodman, D., Cowan, P.,

Hawthorne, W., O'Connell, P., Sutherland, R.,

Lew, A. (2014). Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model. Clinical & Translational

Immunology , 3(12), 1-7.

Chapman, J., McCaughan, G., O'Connell, P.

(2014). Professor Bruce Hall and the ABC.

Medical Journal of Australia , 201(6), 322.

Stewart, J., Tarantal, A., Hawthorne, W.,

Salvaris, E., O'Connell, P., Nottle, M., D'Apice,

A., Cowan, P., Kearns-Jonker, M. (2014).

Rhesus monkeys and baboons develop clotting factor VIII inhibitors in response to porcine endothelial cells or islets. Xenotransplantation ,

21(4), 341-352. <a href="http://dx.doi.org/10.1111/xen.12100">[Mo re Information]</a>

Toki, D., Zhang, W., Hor, K., Liuwantara, D.,

Alexander, S., Yi, Z., Sharma, R., Chapman, J.,

Nankivell (Nankievell), B., Murphy, B.,

O'Connell, P. (2014). The Role of Macrophages in the Development of Human Renal Allograft

Fibrosis in the First Year After Transplantation.

American Journal Of Transplantation , 14(9),


Chen, Y., Stewart, J., Gunthart, M., Hawthorne,

W., Salvaris, E., O'Connell, P., Nottle, M., d'Apice, A., Cowan, P., Kearns-Jonker, M.

(2014). Xenoantibody response to porcine islet cell transplantation using GTKO, CD55, CD59, and fucosyltransferase multiple transgenic donors. Xenotransplantation , 21(3), 244-253. <a href="http://dx.doi.org/10.1111/xen.12091">[Mo re Information]</a>

2013

Cantley, J., Walters, S., Jung, M., Weinberg, A.,

Cowley, M., Whitworth, P., Kaplan, W.,

Hawthorne, W., O'Connell, P., Weir, G., et al

(2013). A Preexistent Hypoxic Gene Signature

Predicts Impaired Islet Graft Function and

Glucose Homeostasis. Cell Transplantation ,

22(11), 2147-2159. <a href="http://dx.doi.org/10.3727/096368912X658


Brady, J., Sutherland, R., Hancock, M.,

Kitsoulis, S., Lahoud, M., Phillips, P.,

Hawthorne, W., d'Apice, A., Cowan, P.,

Harrison, L., O'Connell, P., et al (2013).

Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model. Xenotransplantation , 20(2), 100-109. <a href="http://dx.doi.org/10.1111/xen.12025">[Mo re Information]</a>

Stokes, R., Cheng, K., Deters, N., Lau, S.,

Hawthorne, W., O'Connell, P., Stolp, J., Grey, S.,

Loudovaris, T., Kay, T., Gunton, J., et al (2013).

Hypoxia-inducible factor-1α (HIF-1α) potentiates β-cell survival after islet transplantation of human and mouse islets. Cell

Transplantation , 22(2), 253-266. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.

fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract

&list_uids=22710383">[More Information]</a>

Hu, M., Wang, C., Zhang, G., Saito, M., Wang,

Y., Fernandez, M., Wang, Y., Wu, H.,

Hawthorne, W., Jones, C., O'Connell, P., Bishop,

A., Sharland, A., Alexander, S., et al (2013).

Infiltrating Foxp3+ regulatory T cells from spontaneously tolerant kidney allografts demonstrate donor-specific tolerance. American

Journal of Transplantation , 13, 2819-2830. <a href="http://dx.doi.org/10.1111/ajt.12445">[Mor e Information]</a>

O'Connell, P., Holmes-Walker, J., Goodman, D.,

Hawthorne, W., Loudovaris, T., Gunton, J.,

Thomas, H., Grey, S., Drogemuller, C., Ward,

G., et al (2013). Multicenter Australian Trial of

Islet Transplantation: Improving Accessibility and Outcomes. American Journal of

Transplantation , 13(7), 1850-1858. <a href="http://dx.doi.org/10.1111/ajt.12250">[Mor e Information]</a>

Hu, M., Wu, J., Zhang, G., Wang, Y., Watson,

D., Yi, S., Hawthorne, W., O'Connell, P.,

Alexander, S. (2013). Selective Depletion of

Alloreactive T cells Leads to Long-Term Islet

Allograft Survival Across a Major

Histocompatibility Complex Mismatch in

Diabetic Mice. Cell Transplantation , 22(10),

1929-1941. <a href="http://dx.doi.org/10.3727/096368912X658


Myint, T., Turner, R., Craig, J., Cross, N., Kable,

K., Nankivell, B., Chapman, J., Webster, A.,

O'Connell, P., Dwyer, D., Jeoffreys, N., Wong,

G., et al (2013). Test performance characteristics of quantitative nucleic acid testing for polyomaviruses in kidney and kidney-pancreas transplant recipients. Clinical Transplantation ,

27(5), 571-579. <a href="http://dx.doi.org/10.1111/ctr.12195">[Mor e Information]</a>

O'Connell, P., Cowan, P., Hawthorne, W., Yi, S.,

Lew, A. (2013). Transplantation of Xenogeneic

Islets: Are We There Yet? Current Diabetes

Reports , 13(5), 687-694. <a href="http://dx.doi.org/10.1007/s11892-013-041


2012

Donaghue, K., Keech, A., Craig, M., O'Connell,

P. (2012). A 'cure' for diabetes and its

Publications for Philip O'Connell complications. In Louise A. Baur, Stephen M.

Twigg, Roger S.Magnusson (Eds.), A Modern

Epidemic: Expert Perspectives on Obesity and

Diabetes , (pp. 401-420). Sydney, Australia:

Sydney University Press.

Yi, S., Ji, M., Wu, J., Ma, X., Phillips, P.,

Hawthorne, W., O'Connell, P. (2012). Adoptive

Transfer With In Vitro Expanded Human

Regulatory T Cells Protects Against Porcine Islet

Xenograft Rejection via Interleukin-10 in

Humanized Mice. Diabetes , 61(5), 1180-1191.

<a href="http://dx.doi.org/10.2337/db11-1306">[M ore Information]</a>

Campbell, P., Weinberg, A., Chee, J., Mariana,

L., Ayala, R., Hawthorne, W., O'Connell, P.,

Loudovaris, T., Cowley, M., Kay, T., et al

(2012). Expression of Pro- and Anti-apoptotic

Molecules of the Bcl-2 Family in Human Islets

Postisolation. Cell Transplantation , 21(1), 49-60.

<a href="http://dx.doi.org/10.3727/096368911X566


Yeom, H., Koo, O., Yang, J., Cho, B., Hwang, J.,

Park, S., Hurh, S., Kim, H., Lee, E., Ro, H.,

O'Connell, P., et al (2012). Generation and characterization of human heme oxygenase-1 transgenic pigs. PloS One , 7(10), 1-12. <a href="http://dx.doi.org/10.1371/journal.pone.004


Cowley, M., Weinberg, A., Zammit, N., Walters,

S., Hawthorne, W., Loudovaris, T., Thomas, H.,

Kay, T., Gunton, J., Alexander, S., O'Connell, P., et al (2012). Human islets express a marked proinflammatory molecular signature prior to transplantation. Cell Transplantation , 21(9),

2063-2078. <a href="http://dx.doi.org/10.3727/096368911X627


Barton, F., Rickels, M., Alejandro, R., Hering,

B., Wease, S., Naziruddin, B., Oberholzer, J.,

Odorico, J., Garfinkel, M., Levy, M., O'Connell,

P., et al (2012). Improvement in Outcomes of

Clinical Islet Transplantation: 1999-2010.

Diabetes Care , 35(7), 1436-1445. <a href="http://dx.doi.org/10.2337/dc12-0063">[M ore Information]</a>

Chadban, S., Barraclough, K., Campbell, S.,

Clark, C., Coates, P., Cohney, S., Cross, N., Eris,

J., Henderson, L., Howell, M., O'Connell, P.,

Webster, A., Wong, G., et al (2012). KHA-CARI guideline: KHA-CARI Adaptation of the

KDIGO Clinical Practice Guideline for the Care of Kidney Transplant Recipients. Nephrology ,

17(3), 204-214. <a href="http://dx.doi.org/10.1111/j.1440-1797.201

1.01559.x">[More Information]</a>

Vincenti, F., Tedesco-Silva, H., Busque, S.,


O'Connell, P., Friedewald, J., Cibrik, D., Budde,

K., Yoshida, A., Cohney, S., Weimar, W., et al

(2012). Randomized Phase 2b Trial of

Tofacitinib (CP-690,550) in De Novo Kidney

Transplant Patients: Efficacy, Renal Function and Safety at 1 Year. American Journal Of

Transplantation , 12(9), 2446-2456. <a href="http://dx.doi.org/10.1111/j.1600-6143.201


2011

Blyth, E., Clancy, L., Simms, R., Deo, S.,

O'Connell, P., Micklethwaite, K., Gottlieb, D.

(2011). BK Virus-Specific T Cells for Use in

Cellular Therapy Show Specificity to Multiple

Antigens and Polyfunctional Cytokine

Responses. Transplantation , 92(10), 1077-1084.

<a href="http://dx.doi.org/10.1097/TP.0b013e31823

328c0">[More Information]</a>

Holdaas, H., Rostaing, L., Seron, D., Cole, E.,

Chapman, J., Fellstrom, B., Strom, E., Jardine,

A., Midtvedt, K., Machein, U., O'Connell, P., et al (2011). Conversion of Long-Term Kidney

Transplant Recipients From Calcineurin Inhibitor

Therapy to Everolimus: A Randomized,

Multicenter, 24-Month Study. Transplantation ,

92(4), 410-418. <a href="http://dx.doi.org/10.1097/TP.0b013e31822

4c12d">[More Information]</a>

Hawthorne, W., Simond, D., Stokes, R., Patel,

A., Walters, S., Burgess, J., O'Connell, P. (2011).

Pre-clinical model of composite foetal pig pancreas fragment/renal xenotransplantation to treat renal failure and diabetes.

Xenotransplantation , 18(6), 390-399. <a href="http://dx.doi.org/10.1111/j.1399-3089.201


Hawthorne, W., Simond, D., Stokes, R., Patel,

A., Walters, S., Burgess, J., O'Connell, P. (2011).

Subcapsular Fetal Pig Pancreas Fragment

Transplantation Provides Normal Blood Glucose

Control in a Preclinical Model of Diabetes.

Transplantation , 91(5), 515-521. <a href="http://dx.doi.org/10.1097/TP.0b013e31820


Ji, M., Yi, S., Smith-Hurst, H., Phillips, P., Wu,

J., Hawthorne, W., O'Connell, P. (2011). The

Importance of Tissue Factor Expression by

Porcine NICC in Triggering IBMIR in the

Xenograft Setting. Transplantation , 91(8),

841-846. <a href="http://dx.doi.org/10.1097/TP.0b013e31821


Fisicaro, N., Londrigan, S., Brady, J., Salvaris,

E., Nottle, M., O'Connell, P., Robson, S., d'Apice, A., Lew, A., Cowan, P. (2011).

Versatile co-expression of graft-protective proteins using 2A-linked cassettes.



2010

Sun, L., Yi, S., O'Connell, P. (2010). Foxp3 regulates human natural CD4+CD25+ regulatory

T-cell-mediated suppression of xenogeneic response. Xenotransplantation , 17(2), 121-130.

<a href="http://dx.doi.org/10.1111/j.1399-3089.201


Akalin, E., O'Connell, P. (2010). Genomics of

Chronic Allograft Injury. Kidney International ,

78(Suppl 119), S33-S37. <a href="http://dx.doi.org/10.1038/ki.2010.420">[

More Information]</a>

Cheng, K., Ho, K., Stokes, R., Scott, C., Lau, S.,

Hawthorne, W., O'Connell, P., Loudovaris, T.,

Kay, T., Kulkarni, R., Biankin, A., Kench, J.,

Gunton, J., et al (2010). Hypoxia-inducible factor-1alpha regulates beta cell function in mouse and human islets. Journal of Clinical

Investigation , 120(6), 2171-2183. <a href="http://dx.doi.org/10.1172/JCI35846">[Mor e Information]</a>

Sun, L., Yi, S., O'Connell, P. (2010). IL-10 is required for human CD4+CD25+ regulatory T cell-mediated suppression of xenogeneic proliferation. Immunology and Cell Biology ,

88(4), 477-485. <a href="http://dx.doi.org/10.1038/icb.2009.117">[


Londrigan, S., Sutherland, R., Brady, J.,

Carrington, E., Cowan, P., d’Apice, A.,

O'Connell, P., Zhan, Y., Lew, A. (2010). In Situ

Protection Against Islet Allograft Rejection by

CTLA4Ig Transduction. Transplantation , 90(9),

951-957. <a href="http://dx.doi.org/10.1097/TP.0b013e3181f


O'Connell, P., Yi, S., Carrington, E., Lew, A.

(2010). Role of regulatory T cells in xenotransplantation. Current Opinion in Organ




Vitalone, M., O'Connell, P., Wavamunno, M.,

Fung, C., Chapman, J., Nankivell (Nankievell),

B. (2010). Transcriptome Changes of Chronic

Tubulointerstitial

Damage in Early Kidney Transplantation.

Transplantation , 89(5), 537-547. <a href="http://dx.doi.org/10.1097/TP.0b013e3181c

a7389">[More Information]</a>

2009

Cross, N., Webster, A., Masson, P., O'Connell,

P., Craig, J. (2009). Antihypertensive treatment for kidney transplant recipients. Cochrane

Database of Systematic Reviews , (3), 1-157. <a href="http://dx.doi.org/10.1002/14651858.CD00

3598.pub2">[More Information]</a>

Cross, N., Webster, A., Masson, P., O'Connell,

P., Craig, J. (2009). Antihypertensives for kidney transplant recipients: systematic review and meta-analysis of randomized controlled trials.

Transplantation , 88(1), 7-18. <a href="http://dx.doi.org/10.1097/TP.0b013e3181a

9e960">[More Information]</a>

Cross, N., Webster, A., O'Connell, P., Jeffreys,

N., Dwyer, D., Craig, J. (2009). Diagnostic accuracy of blood qualitative nucleic acid testing for polyomavirus-associated nephropathy in kidney recipients. Nephrology , 14(3), 350-356.

<a href="http://dx.doi.org/10.1111/j.1440-1797.200


Londrigan, S., Brady, J., Sutherland, R., Cowan,

P., d'Apice, A., Hawthorne, W., O'Connell, P.,

Lew, A. (2009). Optimizing transduction of pig islet cell clusters for xenotransplantation.



Suh, N., Ryan, B., Allen, R., O'Connell, P.,

Pleass, H. (2009). Simultaneous pancreas and kidney transplantation from organ donation after cardiac death. ANZ Journal of Surgery , 79(4),

245-256. <a href="http://dx.doi.org/10.1111/j.1445-2197.200


Hering, B., Cooper, D., Cozzi, E., Schuurman,

H., Korbutt, G., Denner, J., O'Connell, P.,

Vanderpool, H., Pierson, R. (2009). The

International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes-- executive summary.



O'Connell, P. (2009). The International

Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--chapter 6: Patient selection for pilot clinical trials of islet xenotransplantation.



Akima, S., Hawthorne, W., Favaloro, E., Patel,

A., Blyth, K., Mudaliar, M., Chapman, J.,


O'Connell, P. (2009). Tirofiban and Activated

Protein C Synergistically Inhibit the Instant

Blood Mediated Inflammatory Reaction (IBMIR) from Allogeneic Islet Cells Exposure to Human

Blood. American Journal Of Transplantation , 9,



Chapman, J., O'Connell, P. (2009). XXII

International Congress of The Transplantation

Society. Transplantation Proceedings , 41(1), 13.

<a href="http://dx.doi.org/10.1016/j.transproceed.20

09.01.031">[More Information]</a>

2008

Vitalone, M., O'Connell, P., Jimenez, E., Yuksel,

A., Wavamunno, M., Fung, C., Chapman, J.,

Nankivell (Nankievell), B. (2008).

Epithelial-to-Mesenchymal Transition in Early

Transplant Tubulointerstitial Damage. Journal of the American Society of Nephrology , 19(8),

1571-1583. <a href="http://dx.doi.org/10.1681/ASN.200705058


Feller, J., Simpson, A., Nelson, M., O'Connell,

P., Swan, M., Hawthorne, W., Tao, C., O'Brien,

B. (2008). Growth Promoting Effect of Rh(D)

Antibody on Human Pancreatic Islet Cells.

Journal of Clinical Endocrinology and

Metabolism , 93(9), 3560-3567. <a href="http://dx.doi.org/10.1210/jc.2008-0510">[


Wu, J., Yi, S., Ouyang, L., Jimenez, E., Simond,

D., Wang, W., Wang, Y., Hawthorne, W.,

O'Connell, P. (2008). In Vitro Expanded Human

CD4+CD25+ Regulatory T Cells are Potent

Suppressors of T-Cell-Mediated Xenogeneic

Responses. Transplantation , 85(12), 1841-1848.

<a href="http://dx.doi.org/10.1097/TP.0b013e31817


Fu, Y., Yi, S., Wu, J., Jimenez-Vera, E., Simond,

D., Hawthorne, W., O'Connell, P. (2008). In vitro suppression of xenoimmune-mediated macrophage activation by human CD4+CD25+ regulatory T cells. Transplantation , 86(6),

865-874. <a href="http://dx.doi.org/10.1097/TP.0b013e31818

530fd">[More Information]</a>

Fu, Y., Lu, X., Yi, S., O'Hara, J., Hawthorne, W.,

Hucker, K., O'Connell, P. (2008). Selective rejection of porcine islet xenografts by macrophages. Xenotransplantation , 15(5),



O'Connell, P. (2008). The rationale and practical

issues for the maintenance of clean herds for clinical islet xenotransplantation.



2007

Lehnert, A., Murray-Segal, L., Cowan, P., d'Apice, A., O'Connell, P. (2007). Blockade of the Passive Cell Death Pathway Does Not

Prevent Tolerance Induction to Islet Grafts.




Chandra, A., Ouyang, L., Yi, S., Wong, J., Ha,

H., Walters, S., Patel, A., Stokes, R., Jardine, M.,

Hawthorne, W., O'Connell, P. (2007).

Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection.

Xenotransplantation , 14(1), 48-59. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Londrigan, S., Brady, J., Sutherland, R.,

Hawthorne, W., Thomas, H., Jhala, G., Cowan,

P., Kay, T., O'Connell, P., Lew, A. (2007).

Evaluation of promoters for driving efficient transgene expression in neonatal porcine islets.




Nankivell (Nankievell), B., Wavamunno, M.,

Borrows, R., Vitalone, M., Fung, C., Allen, R.,

Chapman, J., O'Connell, P. (2007).

Mycophenolate mofetil is associated with altered expression of chronic renal transplant histology.

American Journal Of Transplantation , 7(2),

366-376. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Nottle, M., Beebe, L., Harrison, S., McIlfatrick,

S., Ashman, R., O'Connell, P., Salvaris, E.,

Fisicaro, N., Pommey, S., Cowan, P., et al

(2007). Production of homozygous alpha-1,3-galactosyltransferase knockout pigs by breeding and somatic cell nuclear transfer.




Yi, S., Wang, Y., Chandra, A., O'Hara, J., Wu, J.,

Ouyang, L., Burgess, J., Hawthorne, W., Wu, H.,

Chadban, S., O'Connell, P. (2007). Requirement of MyD88 for macrophage-mediated islet xenograft rejection after adoptive transfer.

Transplantation , 83(5), 615-623. <a

Publications for Philip O'Connell href="http://www.ncbi.nlm.nih.gov/entrez/query.



Wavamunno, M., O'Connell, P., Vitalone, M.,

Fung, C., Allen, R., Chapman, J., Nankivell

(Nankievell), B. (2007). Transplant

Glomerulopathy: Ultrastructural Abnormalities

Occur Early in Longitudinal Analysis of Protocol

Biopsies. American Journal Of Transplantation ,

7(12), 2757-2768. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



2006

Goddard, K., Pleass, H., Cross, N., O'Connell, P.,

Chapman, J., Nankivell (Nankievell), B., Allen,

R. (2006). A twist of fate or fated to twist?

O'Connell, P., Hawthorne, W., Holmes-Walker,

D., Nankivell (Nankievell), B., Gunton, J., Patel,

A., Walters, S., Pleass, H., Allen, R., Chapman,

J. (2006). Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial.

Medical Journal of Australia , 184(5), 221-225.

<a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Akima, S., Hawthorne, W., Koutts, J., Patel, A.,

Burgess, J., O'Hara, J., Mudaliar, Y., Favaloro,

E., O'Connell, P. (2006). Differences in the efficacy of recombinant human activated protein

C against allogeneic and xenogeneic IBMIR.

84(3), A16-A16.

Hawthorne, W., Patel, A., O'Hara, J., Akima, S.,

Salvaris, E., Nottle, M., d'Aspice, A., Cowan, P.,

O'Connell, P. (2006). Elimination of the alpha

Gal antigen on NICC reduces ibmir following exposure of pig NICC to human blood. 24th

Annual Scientific Meeting of the Transplantation

Society of Australia and New Zealand (2006) ,

Australia: Nature Publishing Group.

Vitalone, M., Kirk, M., Allen, R., Pleass, H.,

Chapman, J., O'Connell, P., Nankivell

(Nankievell), B. (2006).

Epithelial-to-mesenchymal transition (EMT) in chronic allograft nephropathy (CAN). 84(3),

A2-A2.

O'Connell, P., Lew, A., Cowan, P., Londrigan,

S., Hawthorne, W., Nottle, M., d'Apice, A.

(2006). Islet xenotransplantation: progress towards a clinical therapy. Current Opinion in

Organ Transplantation , 11(2), 174-179.

Chandra, A., Wong, J., Yi, S., Ha, H., Patel, A.,

O'Connell, P., Hawthorne, W. (2006). Lack of

IL-15 reduces recruitment of xenoreactive leukocytes into discordant islet xenografts but does not prolong graft survival. 24th Annual


Scientific Meeting of the Transplantation Society of Australia and New Zealand (2006) , Australia:

Nature Publishing Group.

Wavamunno, M., Vitalone, M., Borrows, R.,

Fung, C., Allen, R., O'Connell, P., Chapman, J.,

Nankivell (Nankievell), B. (2006).

Mycophenolate mofetil reduces the histological expression of chronic allograft nephropathy.

Immunology and Cell Biology , 84(3), A11-A11.

Simond, D., Moran, C., Garkavenko, O.,

O'Connell, P., Hawthorne, W. (2006). Real-time

PCR detection of porcine endogenous retroviruses. 24th Annual Scientific Meeting of the Transplantation Society of Australia and New

Zealand (2006) , Australia: Nature Publishing

Group.

Robertson, P., Allen, R., O'Connell, P., Pleass,

H., Nankivell (Nankievell), B., Waugh, D.,

Chapman, J. (2006). Transplant beta cell function and the 'lazarus factor'. 84(3), A10-A10.

Chapman, J., Allen, R., Nankivell (Nankievell),

B., O'Connell, P., Fung, C., Kee, T., Kable, K.,

Vitalone, M. (2006). Treatment of Subclinical

Rejection Diagnosed by Protocol Biopsy of

Kidney Transplants. Transplantation , 82(1),




Hawthorne, W., Stokes, R., Patel, A., Burgess, J.,

Walters, S., Simond, D., O'Connell, P. (2006).

Westran fetal pig pancreas fragment transplants provide long-term normoglycaemia in adult pi.

24th Annual Scientific Meeting of the

Transplantation Society of Australia and New

Zealand (2006) , Australia: Nature Publishing

Group.

Allen, R., Lau, H., Nankivell (Nankievell), B.,

O'Connell, P., Lennox, A., Pussell, B., Chapman,

J. (2006). When all the planets are in alignment.

84 (Suppl.)(3), A22-A22.

2005

Wong, K., Kable, K., Hawthorne, W., Robertson,

P., Chan, K., Nankivell (Nankievell), B.,

O'Connell, P., Chapman, J., Lau, H., Pleass, H.,

Allen, R. (2005). A comparison of 2 surgical techniques in pancreas transplantation.


Lee, J., Simond, D., Hawthorne, W., Walters, S.,

Patel, A., Smith, D., O'Connell, P., Moran, C.

(2005). Characterization of the swine major histocompatibility complex alleles at eight loci in

Westran pigs. Xenotransplantation , 12(4),




Chapman, J., O'Connell, P., Nankivell

(Nankievell), B. (2005). Chronic renal allograft dysfunction. Journal of the American Society of

Nephrology , 16(10), 3015-3026. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



O'Connell, P., Hawthorne, W., Simond, D.,

Chapman, J., Chen, Y., Patel, A., Walters, S.,

Burgess, J., Weston, L., Stokes, R., Moran, C.,

Allen, R. (2005). Genetic and Functional evaluation of the level of inbreeding of the

Westran pig: a herd with potential for use in xenotransplantation. Xenotransplantation , 12(4),




Davidson, J., Dotta, F., Home, P., Keown, P.,

Jardine, A., O'Connell, P., Schnitzler, M.,

Torregosa, J., Valantine, H., Villamil, F., et al

(2005). Guidelines for the treatment and management of new-onset diabetes after transplantation. Clinical Transplantation , 19(3),



Yi, S., Ouyang, L., Ha, H., O'Hara, J., Chandra,

A., Akima, S., Hawthorne, W., Patel, A., Stokes,

R., O'Connell, P. (2005). Involvement of CCR5

Signaling in Macrophage

Recruitment to Porcine Islet Xenografts.




Thiel, M., Steiger, J., O'Connell, P., Lehnert, A.,

Coster, D., Williams, K. (2005). Local or short-term systemic costimulatory molecule blockade prolongs rat corneal allograft survival.

Clinical and Experimental Ophthalmology , 33,



Gunton, J., Kulkarni, R., Yim, S., Okada, T.,

Hawthorne, W., Tseng, Y., Roberson, R.,

Ricordi, C., O'Connell, P., Gonzalez, F., et al

(2005). Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell ,

122(3), 337-349. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Mysore, T., Shinkel, T., Collins, J., Salvaris, E.,

Fisicaro, N., Murray-Segal, L., Johnson, L.,

Lepore, D., Walters, S., Stokes, R., Chandra, A.,


O'Connell, P., et al (2005). Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function. Diabetes , 54(7), 2109-16. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Wavamunno, M., Nankivell (Nankievell), B.,

Chapman, J., Kable, K., Allen, R., Pleass, H.,

O'Connell, P. (2005). The impact of screening for BK virus in renal allograft recipients.


Vitalone, M., Nankivell (Nankievell), B., Kirk,

M., Allen, R., Pleass, H., Lau, H., Chapman, J.,

O'Connell, P. (2005). The use of gene arrays to study the pathogenesis of chronic allograft nephropathy (CAN). Immunology and Cell

Biology , 83(4), A26-A26.

O'Connell, P. (2005). Thrombotic microangiopathy: the next big hurdle for xenotransplantation. Journal of the American

Society of Nephrology , 16(9), 2529-30. <a href="http://dx.doi.org/10.1681/ASN.200507073


2004

Harrison, S., Boquest, A., Grupen, C., Faast, R.,

Guildolin, A., Giannakis, C., Crocker, L.,

McIlfatrick, S., Ashman, R., Wengle, J.,

O'Connell, P., d'Apice, A., et al (2004). An

Efficient Method for Producing

α(1,3)-Galactosyltransferase Gene Knockout

Pigs. Cloning and Stem Cells , 6(4), 327-331.

Nankivell (Nankievell), B., Borrows, R., Fung,

C., O'Connell, P., Chapman, J., Allen, R. (2004).

Calcineurin Inhibitor Nephrotoxicity:

Longitudinal Assessment By Protocol Histology.

Transplantation , 78(4), 557-565.


C., O'Connell, P., Chapman, J., Allen, R. (2004).

Delta Analysis Of Posttransplantation

Tubulointerstitial Damage. Transplantation ,

78(3), 434-441.


C., O'Connell, P., Allen, R., Chapman, J. (2004).

Evolution And Pathophysiology Of

Renal-Transplant Glomerulosclerosis.


Chandra, A., Salvaris, E., Walters, S.,

Murray-Segal, L., Gock, H., Lehnert, A., Wong,

J., Cowan, P., d'Apice, A., O'Connell, P. (2004).

Fate Of Alphagal +/+ Pancreatic Islet Grafts

After Transplantation Into Alphagal Knockout

Mice. Xenotransplantation , 11(4), 323-331.



Natural History, Risk Factors, And Impact Of

Subclinical Rejection In Kidney Transplantation.


Zhan, Y., Brown, L., Deliyannis, G., Seah, S.,

Wijburg, O., Price, J., Strugnell, R., O'Connell,

P., Lew, A. (2004). Responses Against Complex

Antigens In Various Models Of Cd4 T-Cell

Deficiency: Surprises From An Anti-Cd4

Antibody Transgenic Mouse. Immunologic

Research , 30(1), 1-14.

2003

Russ, G., Campbell, S., Chadban, S., Eris, J.,

O'Connell, P., Pussell, B., Walker, R. (2003).

Reduced and standard target concentration tacrolimus with sirolimus in renal allograft recipients. Transplantation Proceedings , 35(3),

115S-117S.

Yi, S., Hawthorne, W., Lehnert, A., Ha, H.,

Wong, J., Rooijen, N., Davey, K., Patel, A.,

Walters, S., Chandra, A., O'Connell, P. (2003). T

Cell-Activated Macrophages Are Capable of

Both

Recognition and Rejection of Pancreatic Islet

Xenografts. The Journal of Immunology , 170(5),

2750-2758.



The natural history of chronic allograft nephropathy. New England Journal of Medicine ,

349(24), 2326-2333.

2001

Lehnert, A., Hawthorne, W., O'Connell, P.,

Mottram, P., Han, W., Walters, S., Patel, A.,

Cowan, P., d'Apice, A. (2001). Blockage of the cd28 and cd40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice. Transplant Immunology , 9, 51-56.

Nankivell (Nankievell), B., Fenton Lee, C.,

Allen, R., O'Connell, P., Chapman, J., Kuypers,

D., Cheung,, E. (2001). Effect of Histological damage on long-term kidney transplant outcome.

Transplantation , 71, 515-523.

Nankivell (Nankievell), B., Fenton Lee, C.,

Allen, R., O'Connell, P., Chapman, J., Kuypers,

D. (2001). Histological injury and renal transplant outcome: the cumulative damage hypothesis. Transplantation Proceedings , 33,

1149-1150.

Allen, R., Nankivell (Nankievell), B.,

Hawthorne, W., O'Connell, P., Chapman, J.

(2001). Pancreas and islet transplantation: an unfinished journey. Transplantation

Proceedings , 33, 3485-3488.

2000

Hawthorne, W., Cachia, A., Walters, S., Patel,


A., Clarke, J., O'Connell, P., Chapman, J., Allen,

R. (2000). A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation. Cell Transplantation , 9,

867-875.

Horton, P., Hawthorne, W., Walters, S., Patel,

A., O'Connell, P., Chapman, J., Allen, R. (2000).

Induction of allogenic islet tolerance in a large-animal model. Cell Transplantation , 9,

877-887.

Wallman, L., Stewart, G., Chapman, J.,

O'Connell, P., Fulcher, D. (2000).

Mycophenolate mofetil for treatment of refractory lupus nephritis: four pilot cases.

Internal Medicine Journal , 30, 712-715.

Pai, R., Mitchell, P., Chow, C., Chapman, J.,

O'Connell, P., Allen, R., Nankivell (Nankievell),

B. (2000). Posttransplant cataract: lessons from kidney-pancreas transplantation.

Transplantation , 69, 1108-1114.

Nankivell (Nankievell), B., Lau, S., Chapman, J.,

O'Connell, P., Fletcher, J., Allen, R. (2000).

Progression of macrovascular disease after transplantation. Transplantation , 69, 574-581.

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