Publications for Patrick Tam
Publications for Patrick Tam
2016
Kondo, M., Gray, L., Pelka, G., Leang, S.,
Christodoulou, J., Tam, P., Hannan, A. (2016).
Affective dysfunction in a mouse model of Rett
syndrome: Therapeutic effects of environmental
stimulation and physical activity. Developmental
Neurobiology, 76(2), 39-43. <a
href="http://dx.doi.org/10.1002/dneu.22308">[M
ore Information]</a>
Fossat, N., Radziewic, T., Jones, V., Tourle, K.,
Tam, P. (2016). Conditional restoration and
inactivation of Rbm47 reveal its tissue-context
requirement for viability and growth. Genesis,
54(3), 115-122. <a
href="http://dx.doi.org/10.1002/dvg.22920">[Mo
re Information]</a>
Tam, P., Fossat, N., Wilkie, E., Loebel, D., Ip,
C., Ramialison, M. (2016). Formation of the
Embryonic Head in the Mouse: Attributes of a
Gene Regulatory Network. Current Topics in
Developmental Biology, 117, 497-521. <a
href="http://dx.doi.org/10.1016/bs.ctdb.2015.11.
019">[More Information]</a>
Tam, P. (2016). Human Stem Cells Can
Differentiate in Post-implantation Mouse
Embryos. Cell Stem Cell, 18(1), 3-4. <a
href="http://dx.doi.org/10.1016/j.stem.2015.12.0
10">[More Information]</a>
Peng, G., Suo, S., Chen, J., Chen, W., Liu, C.,
Yu, F., Wang, R., Chen, S., Sun, N., Cui, G.,
Tam, P., et al (2016). Spatial Transcriptome for
the Molecular Annotation of Lineage Fates and
Cell Identity in Mid-gastrula Mouse Embryo.
Developmental Cell, 36(6), 681-697. <a
href="http://dx.doi.org/10.1016/j.devcel.2016.02.
020">[More Information]</a>
Loebel, D., Plageman, T., Tang, T., Jones, V.,
Muccioli, M., Tam, P. (2016). Thyroid bud
morphogenesis requires CDC42- and
SHROOM3-dependent apical constriction.
Biology Open, 5(2), 130-139. <a
href="http://dx.doi.org/10.1242/bio.014415">[M
ore Information]</a>
2015
McShane, S., Mole, M., Savery, D., Greene, N.,
Tam, P., Copp, A. (2015). Cellular basis of
neuroepithelial bending during mouse spinal
neural tube closure. Developmental Biology,
404(2), 113-124. <a
href="http://dx.doi.org/10.1016/j.ydbio.2015.06.
003">[More Information]</a>
Fossat, N., Ip, C., Jones, V., Studdert, J., Khoo,
P., Lewis, S., Power, M., Tourle, K., Loebel, D.,
Kwan, K., Tam, P., et al (2015). Context-specific
function of the LIM homeobox 1 transcription
factor in head formation of the mouse embryo.
Development (Cambridge), 142(11), 2069-2079.
<a
href="http://dx.doi.org/10.1242/dev.120907">[M
ore Information]</a>
Williamson, S., Ellaway, C., Peters, G., Pelka,
G., Tam, P., Christodoulou, J. (2015). Deletion
of protein tyrosine phosphatase, non-receptor
type 4 (PTPN4) in twins with a Rett
syndrome-like phenotype. European Journal of
Human Genetics, 23(9), 1171-1175. <a
href="http://dx.doi.org/10.1038/ejhg.2014.249">
[More Information]</a>
Greenlees, R., Mihelec, M., Yousoof, S., Speidel,
D., Wu, S., Rinkwitz, S., Prokudin, I., Perveen,
R., Cheng, A., Ma, A., Nash, B., Loebel, D.,
Grigg, J., Tam, P., Becker, T., Jamieson, R., et al
(2015). Mutations in SIPA1L3 cause eye defects
through disruption of cell polarity and
cytoskeleton organization. Human Molecular
Genetics, 24(20), 5789-5804. <a
href="http://dx.doi.org/10.1093/hmg/ddv298">[
More Information]</a>
Pera, M., de Wert, G., Dondorp, W.,
Lovell-Badge, R., Mummery, C., Munsie, M.,
Tam, P. (2015). What if stem cells turn into
embryos in a dish? Nature Methods, 12(10),
917-919. <a
href="http://dx.doi.org/10.1038/nmeth.3586">[M
ore Information]</a>
2014
Tanaka, S., Yamaguchi, Y., Jones, V., Tam, P.
(2014). Analyzing gene function in whole mouse
embryo and fetal organ in vitro. In Mark
Lewandoski (Eds.), Mouse Molecular
Embryology: Methods and Protocols, (pp.
367-393). New York: Humana Press. <a
href="http://dx.doi.org/10.1007/978-1-60327-29
2-6-22">[More Information]</a>
Fossat, N., Tourle, K., Radziewic, T., Barratt, K.,
Liebhold, D., Studdert, J., Power, M., Jones, V.,
Loebel, D., Tam, P. (2014). C to U RNA editing
mediated by APOBEC1 requires RNA-binding
protein RBM47. EMBO Reports, 15(8), 903-910.
<a
href="http://dx.doi.org/10.15252/embr.20143845
0">[More Information]</a>
Kaufman-Francis, K., Goh, H., Kojima, Y.,
Studdert, J., Jones, V., Power, M., Wilkie, E.,
Teber, E., Loebel, D., Tam, P. (2014).
Differential response of epiblast stem cells to
Nodal and Activin signalling: A paradigm of
early endoderm development in the embryo.
Philosophical Transactions of the Royal Society
B. Biological Sciences, 369(1657), 1-10. <a
href="http://dx.doi.org/10.1098/rstb.2013.0550"
>[More Information]</a>
Publications for Patrick Tam
Loebel, D., Radziewic, T., Power, M., Studdert,
J., Tam, P. (2014). Generation of mouse embryos
with small hairpin RNA-mediated knockdown of
gene expression. In Mark Lewandoski (Eds.),
Mouse Molecular Embryology: Methods and
Protocols, (pp. 119-142). New York: Humana
Press. <a
href="http://dx.doi.org/10.1007/978-1-60327-29
2-6-8">[More Information]</a>
2013
Ip, C., Fossat, N., Jones, V., Lamonerie, T., Tam,
P. (2014). Head formation: OTX2 regulates
Dkk1 and Lhx1 activity in the anterior
mesendoderm. Development (Cambridge),
141(20), 3859-3867. <a
href="http://dx.doi.org/10.1242/dev.114900">[M
ore Information]</a>
Maxwell, S., Pelka, G., Tam, P., El-Osta, A.
(2013). Chromatin context and ncRNA highlight
targets of MeCP2 in brain. RNA Biology, 10(11),
1741-1757. <a
href="http://dx.doi.org/10.4161/rna.26921">[Mo
re Information]</a>
Hamada, H., Tam, P. (2014). Mechanisms of
left-right asymmetry and patterning: driver,
mediator and responder. F1000 Prime Reports,
6, 1-9. <a
href="http://dx.doi.org/10.12703/P6-110">[More
Information]</a>
Gold, W., Williamson, S., Kaur, S., Hargreaves,
I., Land, J., Pelka, G., Tam, P., Christodoulou, J.
(2014). Mitochondrial dysfunction in the skeletal
muscle of a mouse model of Rett syndrome
(RTT): Implications for the disease phenotype.
Mitochondrion, 15, 10-17. <a
href="http://dx.doi.org/10.1016/j.mito.2014.02.0
12">[More Information]</a>
Fossat, N., Tam, P. (2014). Re-editing the
paradigm of Cytidine (C) to Uridine (U) RNA
editing. RNA Biology, 11(10), 1233-1237. <a
href="http://dx.doi.org/10.1080/15476286.2014.
996054">[More Information]</a>
Kojima, Y., Kaufman-Francis, K., Studdert, J.,
Steiner, K., Power, M., Loebel, D., Jones, V.,
Hor, A., de Alencastro, G., Logan, G.,
Alexander, I., Pickett, H., Tam, P., et al (2014).
The Transcriptional and Functional Properties of
Mouse Epiblast Stem Cells Resemble the
Anterior Primitive Streak. Cell Stem Cell, 14(1),
107-120. <a
href="http://dx.doi.org/10.1016/j.stem.2013.09.0
14">[More Information]</a>
Loebel, D., Hor, A., Bildsoe, H., Tam, P. (2014).
Timed Deletion of Twist1 in the Limb Bud
Reveals Age-Specific Impacts on Autopod and
Zeugopod Patterning. PloS One, 9(6), e98945. <a
href="http://dx.doi.org/10.1371/journal.pone.009
8945">[More Information]</a>
Kojima, Y., Tam, O., Tam, P. (2014). Timing of
developmental events in the early mouse
embryo. Seminars in Cell & Developmental
Biology, 34, 65-75. <a
href="http://dx.doi.org/10.1016/j.semcdb.2014.0
6.010">[More Information]</a>
Neumann, A., Watson, C., Noble, J., Pickett, H.,
Tam, P., Reddel, R. (2013). Alternative
lengthening of telomeres in normal mammalian
somatic cells. Genes and Devleopment, 27(1),
18-23. <a
href="http://dx.doi.org/10.1101/gad.205062.112"
>[More Information]</a>
Tanaka, S., Nakane, A., Yamaguchi, Y.,
Terabayashi, T., Abe, T., Nakao, K., Asashima,
M., Steiner, K., Tam, P., Nishinakamura, R.
(2013). Dullard/Ctdnep1 Modulates WNT
Signalling Activity for the Formation of
Primordial Germ Cells in the Mouse Embryo.
PloS One, 8(3), 1-14. <a
href="http://dx.doi.org/10.1371/journal.pone.005
7428">[More Information]</a>
Funnell, A., Mak, K., Twine, N., Pelka, G.,
Norton, L., Radziewic, T., Power, M., Wilkins,
M., Bell-Anderson, K., Fraser, S., Tam, P., et al
(2013). Generation of mice deficient in both
KLF3/BKLF and KLF8 reveals a genetic
interaction and a role for these factors in
embryonic globin gene silencing. Molecular and
Cellular Biology, 33(15), 2976-2987. <a
href="http://dx.doi.org/10.1128/MCB.00074-13"
>[More Information]</a>
Tam, P., Nelson, W., Rossant, J. (2013).
Mammalian Development: Networks, Switches,
and Morphogenetic Processes. New York: Cold
Spring Harbor Laboratory Press.
Stephenson, R., Rossant, J., Tam, P. (2013).
Reprint: Intercellular Interactions, Position, and
Polarity in Establishing Blastocyst Cell Lineages.
In Patrick P. L. Tam, W. James Nelson, Janet
Rossant (Eds.), Mammalian Development:
Networks, Switches, and Morphogenetic
Processes, (pp. 167-182). New York: Cold
Spring Harbor Laboratory Press.
Tam, P., Pera, M. (2013). Stem cell science and
regenerative medicine. BioEssays : news and
reviews in molecular cellular and
developmental biology, 35(3), 147-148. <a
href="http://dx.doi.org/10.1002/bies.201300003"
>[More Information]</a>
Bildsoe, H., Loebel, D., Jones, V., Hor, A.,
Braithwaite, A., Chen, Y., Behringer, R., Tam, P.
(2013). The mesenchymal architecture of the
cranial mesoderm of mouse embryos is disrupted
by the loss fof Twist1 function. Developmental
Biology, 374(2), 295-307. <a
Publications for Patrick Tam
href="http://dx.doi.org/10.1016/j.ydbio.2012.12.
004">[More Information]</a>
Ng, H., Tam, P. (2013). The mystique of cellular
reprogramming. Current Opinion in Genetics &
Development, 23(5), 501-503. <a
href="http://dx.doi.org/10.1016/j.gde.2013.08.00
1">[More Information]</a>
Arkell, R., Fossat, N., Tam, P. (2013). Wnt
signalling in mouse gastrulation and anterior
development: new players in the pathway and
signal output. Current Opinion in Genetics &
Development, 23(4), 454-460. <a
href="http://dx.doi.org/10.1016/j.gde.2013.03.00
1">[More Information]</a>
2012
Williamson, S., Giudici, L., Kilstrup-Nielsen, C.,
Gold, W., Pelka, G., Tam, P., Grimm, A., Prodi,
D., Landsberger, N., Christodoulou, J. (2012). A
novel transcript of cyclin-dependent kinase-like
5 (CDKL5) has an alternative C-terminus and is
the predominant transcript in brain. Human
Genetics, 131(2), 187-200. <a
href="http://dx.doi.org/10.1007/s00439-011-105
8-x">[More Information]</a>
Arkell, R., Tam, P. (2012). Initiating head
development in mouse embryos: integrating
signalling and transcriptional activity. Open
Biology, 2(March 2012), 1-10. <a
href="http://dx.doi.org/10.1098/rsob.120030">[
More Information]</a>
Stephenson, R., Rossant, J., Tam, P. (2012).
Intercellular interactions, position, and polarity
in establishing blastocyst cell lineages and
embryonic axes. Cold Spring Harbor
Perspectives in Biology, 4(11), 1-15. <a
href="http://dx.doi.org/10.1101/cshperspect.a008
235">[More Information]</a>
Fossat, N., Jones, V., Garcia-Garcia, M., Tam, P.
(2012). Modulation of WNT signaling activity is
key to the formation of the embryonic head. Cell
Cycle, 11(1), 26-32. <a
href="http://dx.doi.org/10.4161/cc.11.1.18700">[
More Information]</a>
Loebel, D., Hor, A., Bildsoe, H., Jones, V.,
Chen, Y., Behringer, R., Tam, P. (2012).
Regionalized Twist1 activity in the forelimb bud
drives the morphogenesis of the proximal and
preaxial skeleton. Developmental Biology,
362(2), 132-140. <a
href="http://dx.doi.org/10.1016/j.ydbio.2011.11.
020">[More Information]</a>
Loebel, D., Tam, P. (2012). Rho GTPases in
endoderm development and differentiation.
Small GTPases, 3(1), 40-44. <a
href="http://dx.doi.org/10.4161/sgtp.3.1.18820">
[More Information]</a>
2011
Tam, P. (2011), Endoderm Formation: Not So
Black and White Anymore. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=22014529">[More Information]</a>
Coombes, A., Bowles, J., Feng, C., Chiu, H.,
Khoo, P., Jackson, A., Little, M., Tam, P.,
Koopman, P. (2011). Expression and functional
analysis of Dkk1 during early gonadal
development. Sexual Development, 5(3),
124-130. <a
href="http://dx.doi.org/10.1159/000327709">[M
ore Information]</a>
Tanaka, S., Kojima, Y., Yamaguchi, Y.,
Nishinakamura, R., Tam, P. (2011). Impact of
WNT signaling on tissue lineage differentiation
in the early mouse embryo. Development,
Growth and Differentiation, 53(7), 843-856. <a
href="http://dx.doi.org/10.1111/j.1440-169X.201
1.01292.x">[More Information]</a>
Fossat, N., Loebel, D., Jones, V., Khoo, P.,
Bildsoe, H., Tam, P. (2011). Marking Cells for
Imaging Analysis of Morphogenetic Behavior
and Cell Fates in Mouse Embryos. In James
Sharpe, Rachel Wong (Eds.), Imaging in
Developmental Biology: A Laboratory Manual,
(pp. 311-329). Woodbury, New York, USA:
Cold Spring Harbor Laboratory Press.
Loebel, D., Studdert, J., Power, M., Radziewic,
T., Jones, V., Coultas, L., Jackson, Y., Rao, R.,
Steiner, K., Fossat, N., Tam, P., et al (2011).
Rhou maintains the epithelial architecture and
facilitates differentiation of the foregut
endoderm. Development (Cambridge), 138(20),
4511-4522. <a
href="http://dx.doi.org/10.1242/dev.063867">[M
ore Information]</a>
Pfister, S., Jones, V., Power, M., Truisi, G.,
Khoo, P., Steiner, K., Kanai-Azuma, M., Kanai,
Y., Tam, P., Loebel, D. (2011). Sox17-dependent
gene expression and early heart and gut
development in Sox17-deficient mouse embryos.
International Journal of Developmental Biology,
55(1), 45-58. <a
href="http://dx.doi.org/10.1387/ijdb.103158sp">
[More Information]</a>
Fossat, N., Jones, V., Khoo, P., Bogani, D.,
Hardy, A., Steiner, K., Mukhopadhyay, M.,
Westphal, H., Nolan, P., Arkell, R., Tam, P.
(2011). Stringent Requirement of a Proper Level
of Canonical WNT Signalling Activity for Head
Formation in Mouse Embryo. Development
(Cambridge), 138(4), 667-676. <a
href="http://dx.doi.org/10.1242/dev.052803">[M
ore Information]</a>
2010
Publications for Patrick Tam
Harikrishnan, K., Bayles, R., Ciccotosto, G.,
Maxwell, S., Cappai, R., Pelka, G., Tam, P.,
Christodoulou, J., El-Osta, A. (2010). Alleviating
Transcriptional Inhibition of the Norepinephrine
Slc6a2 Transporter Gene in Depolarized
Neurons. The Journal of Neuroscience, 30(4),
1494-1501. <a
href="http://dx.doi.org/10.1523/JNEUROSCI.46
75-09.2010">[More Information]</a>
Rivera-Perez, J., Jones, V., Tam, P. (2010).
Culture of Whole Mouse Embryos at Early
Postimplantation to Organogenesis Stages:
Developmental Staging and Methods. In Paul
M. Wassarman and Philippe M. Soriano (Eds.),
Methods in Enzymology Volume 476: Guide to
Techniques in Mouse Development, Part A:
Mice, Embryos, and Cells, (pp. 185-203). United
States: Elsevier.
Pera, M., Tam, P. (2010). Extrinsic regulation of
pluripotent stem cells. Nature, 465(7299),
713-720. <a
href="http://dx.doi.org/10.1038/nature09228">[
More Information]</a>
Tanaka, S., Yamaguchi, Y., Steiner, K., Nakano,
T., Nishinakamura, R., Kwan, K., Behringer, R.,
Tam, P. (2010). Loss of Lhx1 activity impacts on
the localization of primordial germ cells in the
mouse. Developmental Dynamics, 239(11),
2851-2859. <a
href="http://dx.doi.org/10.1002/dvdy.22417">[M
ore Information]</a>
Leung, A., Wong, S., Chan, D., Tam, P., Cheah,
K. (2010). Loss of Procollagen IIA From the
Anterior Mesendoderm Disrupts the
Development of Mouse Embryonic Forebrain.
Developmental Dynamics, 239(9), 2319-2329. <a
href="http://dx.doi.org/10.1002/dvdy.22366">[M
ore Information]</a>
Fath, T., Chan, Y., Vrhovski, B., Clarke, H.,
Curthoys, N., Hook, J., Lemckert, F., Schevzov,
G., Tam, P., Watson, C., Gunning, P., et al
(2010). New aspects of tropomyosin-regulated
neuritogenesis revealed by the deletion of
Tm5NM1 and 2. European Journal of Cell
Biology, 89(7), 489-498. <a
href="http://dx.doi.org/10.1016/j.ejcb.2009.11.02
8">[More Information]</a>
Weaving, L., Mihelec, M., Storen, R., Sosic, D.,
Grigg, J., Tam, P., Jamieson, R. (2010). Twist2:
Role in Corneal Stromal Keratocyte Proliferation
and Corneal Thickness. Investigative
Ophthalmology and Visual Science, 51(11),
5561-5570. <a
href="http://dx.doi.org/10.1167/iovs.09-5123">[
More Information]</a>
2009
Rossant, J., Tam, P. (2009). Blastocyst lineage
formation, early embryonic asymmetries and axis
patterning in the mouse. Development
(Cambridge), 136(5), 701-713. <a
href="http://dx.doi.org/10.1242/dev.017178">[M
ore Information]</a>
Mihelec, M., Abraham, P., Gibson, K., Krowka,
R., Susman, R., Storen, R., Chen, Y., Donald, J.,
Tam, P., Flaherty, M., Grigg, J., Jamieson, R., et
al (2009). Novel SOX2 partner-factor domain
mutation in a four-generation family. European
Journal of Human Genetics, 17(11), 1417-1422.
<a
href="http://dx.doi.org/10.1038/ejhg.2009.79">[
More Information]</a>
Bildsoe, H., Loebel, D., Jones, V., Chen, Y.,
Behringer, R., Tam, P. (2009). Requirement for
Twist1 in frontonasal and skull vault
development in the mouse embryo.
Developmental Biology, 331(2), 176-188. <a
href="http://dx.doi.org/10.1016/j.ydbio.2009.04.
034">[More Information]</a>
Tam, P., Loebel, D. (2009). Specifying mouse
embryonic germ cells. Cell, 137(3), 398-400. <a
href="http://dx.doi.org/10.1016/j.cell.2009.04.01
6">[More Information]</a>
Grassinger, J., Haylock, D., Storan, M., Haines,
G., Williams, B., Whitty, G., Vinson, A., Be, C.,
Li, S., Tam, P. (2009). Thrombin-cleaved
osteopontin regulates hemopoietic stem and
progenitor cell functions through interactions
with α9β1 and α4β1 integrins. Blood, 114(1),
49-59. <a
href="http://dx.doi.org/10.1182/blood-2009-01-1
97988">[More Information]</a>
2008
Watson, C., Trainor, P., Radziewic, T., Pelka, G.,
Zong, Z., Parameswaran, M., Quinlan, G.,
Gordon, M., Sturm, K., Tam, P., et al (2008).
Application of lacZ Transgenic Mice to Cell
Lineage Studies. Methods in Molecular Biology,
461, 149-164. <a
href="http://dx.doi.org/10.1007/978-1-60327-48
3-8_10">[More Information]</a>
Furtado, M., Solloway, M., Jones, V., Costa, M.,
Biben, C., Wolstein, O., Preis, J., Sparrow, D.,
Saga, Y., Dunwoodie, S., et al (2008).
BMP/SMAD1 signaling sets a threshold for the
left/right pathway in lateral plate mesoderm and
limits availability of SMAD4. Genes and
Development, 22, 3037-3049. <a
href="http://dx.doi.org/10.1101/gad.1682108">[
More Information]</a>
Quinlan, G., Khoo, P., Wong, N., Trainor, P.,
Tam, P. (2008). Cell grafting and labeling in
postimplantation mouse embryos. Methods in
Molecular Biology, 461, 47-70. <a
href="http://dx.doi.org/10.1007/978-1-60327-48
Publications for Patrick Tam
3-8_6">[More Information]</a>
Mihelec, M., St Heaps, L., Flaherty, M., Billson,
F., Rudduck, C., Tam, P., Grigg, J., Peters, G.,
Jamieson, R. (2008). Chromosomal
Rearrangements and Novel Genes in Disorders
of Eye Development, Cataract and Glaucoma.
Twin Research and Human Genetics, 11(4),
412-421. <a
href="http://dx.doi.org/10.1375/twin.11.4.412">[
More Information]</a>
Lewis, S., Khoo, P., Young, A., Steiner, K.,
Willcock, C., Mukhopadhyay, M., Westphal, H.,
Jamieson, R., Robb, L., Tam, P. (2008). Dkk1
and Wnt3 interact to control head morphogenesis
in the mouse. Development (Cambridge),
135(10), 1791-1801. <a
href="http://dx.doi.org/10.1242/dev.018853">[M
ore Information]</a>
Kondo, M., Gray, L., Pelka, G., Christodoulou,
J., Tam, P., Hannan, A. (2008). Environmental
enrichment ameliorates a motor coordination
deficit in a mouse model of Rett syndrome Mecp2 gene dosage effects and BDNF
expression. European Journal of Neuroscience,
27(12), 3342-3350. <a
href="http://dx.doi.org/10.1111/j.1460-9568.200
8.06305.x">[More Information]</a>
Franklin, V., Khoo, P., Bildsoe, H., Wong, N.,
Lewis, S., Tam, P. (2008). Regionalisation of the
endoderm progenitors and morphogenesis of the
gut portals of the mouse embryo. Mechanisms of
Development, 125(7), 587-600. <a
href="http://dx.doi.org/10.1016/j.mod.2008.04.0
01">[More Information]</a>
2007
Fossat, N., Pfister, S., Tam, P. (2007). A
transcriptome landscape of mouse
embryogenesis. Developmental Cell, 13(6),
761-762. <a
href="http://dx.doi.org/10.1016/j.devcel.2007.11.
011">[More Information]</a>
Tam, P., Lovell-Badge, R. (2007). Anne
McLaren 1927-2007. Cell, 130(2), 201-213. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17712928">[More Information]</a>
Jamieson, R., Farrar, N., Stewart, K., Perveen,
R., Mihelec, M., Carette, M., Grigg, J., McAvoy,
J., Lovicu, F., Tam, P., et al (2007).
Characterization of a familial t(16;22) balanced
translocation associated with congenital cataract
leads to identification of a novel gene,
TMEM114, expressed in the lens and disrupted
by the translocation. Human Mutation, 28(10),
968-977. <a
href="http://dx.doi.org/10.1002/humu.20545">[
More Information]</a>
Tanaka, S., Yamaguchi, Y., Tam, P. (2007).
Experimental approaches to study gene function
in whole mouse embryo and fetal ovary in vitro.
7th Transgenic Technology (TT) Meeting
(TT2007), Netherlands: Springer-Verlag
Dordrecht.
Franklin, V., Bildsoe, H., Tam, P. (2007).
Fate-Mapping Technique: Grafting Fluorescent
Cells into Gastrula-Stage Mouse Embryos at
7-7.5 Days Post-coitum. CSH protocols, 2007,
4892. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=21356983">[More Information]</a>
Khoo, P., Franklin, V., Tam, P. (2007).
Fate-Mapping Technique: Targeted
Whole-Embryo Electroporation of DNA
Constructs into the Germ Layers of Mouse
Embryos 7-7.5 Days Post-coitum. CSH
protocols, 2007, 4893. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=21356984">[More Information]</a>
Bildsoe, H., Franklin, V., Tam, P. (2007).
Fate-mapping technique: using carbocyanine
dyes for vital labeling of cells in gastrula-stage
mouse embryos cultured in vitro. CSH protocols,
2007, 4915. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=21357005">[More Information]</a>
Pfister, S., Steiner, K., Tam, P. (2007). Gene
expression pattern and progression of
embryogenesis in the immediate
post-implantation period of mouse development.
Gene Expression Patterns, 7(5), 558-573. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17331809">[More Information]</a>
Tam, P., Loebel, D. (2007). Gene function in
mouse embryogenesis: get set for gastrulation.
Nature Reviews Genetics, 8(5), 368-381. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17387317">[More Information]</a>
Lewis, S., Khoo, P., De Young, R., Bildsoe, H.,
Wakamiya, M., Behringer, R., Mukhopadhyay,
M., Westphal, H., Tam, P. (2007). Genetic
interaction of Gsc and Dkk1 in head
morphogenesis of the mouse. Mechanisms of
Development, 124(2), 157-165. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17127040">[More Information]</a>
Tam, P., Khoo, P., Lewis, S., Bildsoe, H., Wong,
N., Tsang, T., Gad, J., Robb, L. (2007).
Sequential allocation and global pattern of
movement of the definitive endoderm in the
Publications for Patrick Tam
mouse embryo during gastrulation. Development
(Cambridge), 134(2), 251-260. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17151016">[More Information]</a>
2006
Tam, P., Loebel, D., Tanaka, S. (2006). Building
the mouse gastrula: signals, asymmetry and
lineages. Current Opinion In Genetics and
Development, 16(4), 419-425. <a
href="http://dx.doi.org/10.1016/j.gde.2006.06.00
8">[More Information]</a>
Willcock, C., Grigg, J., Wilson, M., Tam, P.,
Billson, F., Jamieson, R. (2006). Congenital iris
ectropion as an indicator of variant aniridia.
British Journal of Ophthalmology, 90(5),
658-659.
Lewis, S., Tam, P. (2006). Definitive endoderm
of the mouse embryo: Formation, cell fates, and
morphogenetic function. Developmental
Dynamics, 235(9), 2315-2329. <a
href="http://dx.doi.org/10.1002/dvdy.20846">[M
ore Information]</a>
Nolen, L., Amor, D., Haywood, A., St. Heaps,
L., Willcock, C., Mihelec, M., Tam, P., Billson,
F., Grigg, J., Peters, G., Jamieson, R. (2006).
Deletion at 14q22-23 indicates a contiguous gene
syndrome comprising anophthalmia, pituitary
hypoplasia, and ear anomalies. American Journal
of Medical Genetics. Part A, 140(16),
1711-1718. <a
href="http://dx.doi.org/10.1002/ajmg.a.31335">[
More Information]</a>
Duffy, S., Steiner, K., Tam, P., Boyd, A. (2006).
Expression analysis of the Epha1 receptor
tyrosine kinase and its high-affinity ligands
Efna1 and Efna3 during early mouse
development. Gene Expression Patterns, 6(7),
719-723. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16466970">[More Information]</a>
Yamaguchi, Y., Tanaka, S., Kasa, M., Yasuda,
K., Tam, P., Matsui, Y. (2006). Expression of
low density lipoprotein receptor-related protein 4
(Lrp4) gene in the mouse germ cells. Gene
Expression Patterns, 6(6), 607-612. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16434236">[More Information]</a>
Pelka, G., Watson, C., Radziewic, T., Hayward,
M., Lahooti, H., Christodoulou, J., Tam, P.
(2006). Mecp2 deficiency is associated with
learning and cognitive deficits and altered gene
activity in the hippocampal region of mice.
Brain, 129(Pt 4), 887-898. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16467389">[More Information]</a>
Yamaguchi, Y., Tanaka, S., Yasuda, K., Matsui,
Y., Tam, P. (2006). Stage-specific Importin13
activity influences meiosis of germ cells in the
mouse. Developmental Biology, 297(2), 350-360.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16908015">[More Information]</a>
2005
Loebel, D., Tsoi, B., Wong, N., Tam, P. (2005).
A conserved noncoding intronic transcript at the
mouse Dnm3 locus. Genomics. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15885504">[More Information]</a>
Loebel, D., Tam, P. (2005). A gut feeling.
Nature Biotechnology, 23(12), 1491-1492. <a
href="http://dx.doi.org/10.1038/nbt1205-1491">[
More Information]</a>
Pelka, G., Watson, C., Christodoulou, J., Tam, P.
(2005). Distinct expression profiles of Mecp2
transcripts with different lengths of 3'UTR in the
brain and visceral organs during mouse
development. Genomics, 85(4), 441-452. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15780747">[More Information]</a>
Tanaka, S., Yamaguchi, Y., Tsoi, B., Lickert, H.,
Tam, P. (2005). IFITM/Mil/fragilis family
proteins IFITM1 and IFITM3 play distinct roles
in mouse primordial germ cell homing and
repulsion. Developmental Cell, 9(6), 745-756. <a
href="http://dx.doi.org/10.1016/j.devcel.2005.10.
010">[More Information]</a>
Watson, C., Pelka, G., Radziewic, T.,
Shahbazian, M., Christodoulou, J., Williamson,
S., Tam, P. (2005). Reduced proportion of
Purkinje cells expressing
paternally derived mutant Mecp2 308 allele in
female mouse cerebellum is not due to a skewed
primary pattern of X-chromosome inactivation.
Human Molecular Genetics, 14(13), 1851-1861.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15888476">[More Information]</a>
2004
Ding, H., Wu, X., Bostrom, H., Kim, I., Wong,
N., Tsoi, B., O'Rourke, M., Koh, G., Soriano, P.,
Betsholtz, C., Tam, P., et al (2004). A Specific
Requirement For PDGF-C In Palate Formation
And PDGFR-Alpha Signaling. Nature Genetics,
36(10), 1111-1116.
Tam, P. (2004). Embryonic Axes: The Long And
Publications for Patrick Tam
Short Of It In The Mouse. Current Biology,
14(6), R239-R241. <a
href="http://dx.doi.org/10.1016/j.cub.2004.02.05
6">[More Information]</a>
Early endoderm development in vertebrates:
lineage differentiation and morphogenetic
function. Current Opinion In Genetics and
Development, 13(4), 393-400.
Rossant, J., Tam, P. (2004). Emerging
Asymmetry And Embryonic Patterning In Early
Mouse Development. Developmental Cell, 7(2),
155-164. <a
href="http://dx.doi.org/10.1016/j.devcel.2004.07.
012">[More Information]</a>
Loebel, D., Watson, C., De Young, R., Tam, P.
(2003). Lineage choice and differentiation in
mouse embryos and embryonic stem cells.
Developmental Biology, 264(1), 1-14.
Robb, L., Tam, P. (2004). Gastrula Organiser
And Embryonic Patterning In The Mouse.
Seminars in Cell and Developmental Biology,
15(5), 543-554.
Weaving, L., Christodoulou, J., Williamson, S.,
Friend, K., McKenzie, O., Archer, H., Evans, J.,
Clarke, A., Pelka, G., Tam, P., Lahooti, H.,
Ellaway, C., Bennetts, B., Watson, C., et al
(2004). Mutations Of Cdkl5 Cause A Severe
Neurodevelopmental Disorder With Infantile
Spasms And Mental Retardation. American
Journal of Human Genetics, 75, 1079-1093.
Tam, P., Khoo, P., Wong, N., Tsang, T.,
Behringer, R. (2004). Regionalization Of Cell
Fates And Cell Movement In The Endoderm Of
The Mouse Gastrula And The Impact Of Loss Of
Lhx1(Lim1) Function. Developmental Biology,
274(1), 171-187.
Tanaka, S., Nagamatsu, G., Tokitake, Y., Kasa,
M., Tam, P., Matsui, Y. (2004). Regulation Of
Expression Of Mouse Interferon-Induced
Transmembrane Protein Like Gene-3, Ifitm3
(Mil-1, Fragilis), In Germ Cells. Developmental
Dynamics, 230(4), 651-659. <a
href="http://dx.doi.org/10.1002/dvdy.20085">[M
ore Information]</a>
Ding, H., Schertzer, M., Wu, X., Gertsenstein,
M., Selig, S., Kammori, M., Pourvali, R., Poon,
S., Vulto, I., et, A., Tam, P. (2004). Regulation
Of Murine Telomere Length By Rtel: An
Essential Gene Encoding A Helicase-Like
Protein. Cell, 117(7), 873-886. <a
href="http://dx.doi.org/10.1016/j.cell.2004.05.02
6">[More Information]</a>
Loebel, D., Tsoi, B., Wong, N., O'Rourke, M.,
Tam, P. (2004). Restricted Expression Of
Etn-Related Sequences During Post-Implantation
Mouse Development. Gene Expression Patterns,
4(4), 467-471.
2003
Hukriede, N., Tsang, T., Habas, R., Khoo, P.,
Steiner, K., Weeks, D., Tam, P., Dawid, I.
(2003). Conserved requirement of Lim1 function
for cell movements during gastrulation.
Developmental Cell, 4(1), 83-94.
Tam, P., Kanai-Azuma, M., Kanai, Y. (2003).
Tam, P., Rossant, J. (2003). Mouse embryonic
chimeras: tools for studying mammalian
development. Development (Cambridge), 130,
6155-6163.
2002
Stone, L., Tan, S., Tam, P., Finger, T. (2002).
Analysis of Cell Lineage Relationships in Taste
Buds. The Journal of Neuroscience, 22(11),
4522-4529.
Kanai-Azuma, M., Kanai, Y., Gad, J., Tajima,
Y., Taya, C., Kurohmaru, M., Sanai, Y.,
Yonekawa, H., Yazaki, K., Tam, P., et al (2002).
Depletion of definitive gut endoderm in
Sox17-null mutant mice. Development
(Cambridge), 129(10), 2367-2379.
Ristevski, S., Tam, P., Hertzog, P., Kola, I.
(2002). Ets2 is expressed during morphogenesis
of the somite and limb in the mouse embryo.
Mechanisms of Development, 116, 165-168.
Tam, P. (2002). First mitotic division: getting it
right at the start. Nature Cell Biology, 4(10),
E232-E232.
Loebel, D., O'Rourke, M., Steiner, K., Banyer, J.,
Tam, P. (2002). Isolation of Differentially
Expressed Genes from Wild-Type and Twist
Mutant Mouse Limb Buds. Genesis, 33(3),
103-113. <a
href="http://dx.doi.org/10.1002/gene.10091">[M
ore Information]</a>
Hart, A., Hartley, L., Sourris, K., Stadler, E., Li,
R., Stanley, E., Tam, P., Elefanty, A., Robb, L.
(2002). Mixl1 is required for axial mesendoderm
morpogenesis and patterning in the murine
embryo. Development (Cambridge), 129(15),
3597-3608.
Tam, P., Rossant, J. (2002). Mouse
Development: Patterning, Morphogenesis and
Organogensis. San Francisco United States:
Academic Press.
Tam, P., Gossler, A. (2002). Somitogenesis:
Segmentation of the Paraxial Mesodeerm and the
delineation of tissue compartments. In Janet
Rossant & Patrick L. Tam (Eds.), Mouse
Development, (pp. 127-149). San Francisco:
Staempfli Publishers Ltd.
Soo, K., O'Rourke, M., Khoo, P., Steiner, K.,
Wong, N., Behringer, R., Tam, P. (2002). Twist
Function is Required for morphogenesis of the
Publications for Patrick Tam
Cephalic Neural Tuve and the Differentiation of
the Cranial Neura Crest Cells in the Mouse
Embryo. Developmental Biology, 247(2),
251-270. <a
href="http://dx.doi.org/10.1006/dbio.2002.0699"
>[More Information]</a>
O'Rourke, M., Tam, P. (2002). Twist Functions
in mouse development. International Journal of
Developmental Biology, 46(4), 401-413.
O'Rourke, M., Soo, K., Behringer, R., Hui, C.,
Tam, P. (2002). Twist plays an essential role in
FGF and SHH Signal Transduction during
Mouse Limb Development. Developmental
Biology, 248(1), 143-156. <a
href="http://dx.doi.org/10.1006/dbio.2002.0730"
>[More Information]</a>
2001
Kinder, S., Tam, P., Loebel, D. (2001).
Allocation and Early Differentiation of
Cardiovascular Progenitors in the Mouse
Embryo. Trends In Cardiovascular Medicine, 11,
177-183.
Tam, P., Hadjantonakis, A., Cox,, L., Nagy,, A.
(2001). An X-linked GFP transgene reveals
unexpected paternal X-Chromosome activity in
trophoblastic Giant Cells of the Mouse Placenta.
Genesis, 29, 133-140.
Tam, P., Watson,, C. (2001). Cell Lineage
Determination in the Mouse. Cell Structure and
Function, 26, 123-129.
Kinder, S., Tsang, T., Tam, P., Ang,, S.,
Behringer, R. (2001). Defects of the body plan of
mutant embryos lacking Lim1, Otx2 or Hnf3B
activity. International Journal of Developmental
Biology, 45, 347-355.
Tam, P., Ristevski, S., Kola,, I., Hertzog, P.
(2001). Desrt, an AT-rich interaction domain
family transcription factor gene, is an early
marker for nephrogenic mesoderm and is
expressed dynamically during mourse limb
development. Mechanisms of Development, 104,
139-142.
Tam, P., So, C., Cheah, K. (2001). Impact of
mutations of cartilage matrix genes on matrix
structure, gene activity and chondrogenesis.
Osteoarthritis and Cartilage, 9.
Orford, J., Manglick, P., Cass, D., Tam, P.
(2001). Mechanisms for the development of
esophageal atresia. Journal of Pediatric Surgery,
36(7), 985-994.
Tam, P., Kinder, S., Tsang, T., Gad, J.,
Behringer, R. (2001). Morphogenetic tissue
movement and the establishment of body plan
during development from blastocyst to gastrula
in the mouse. BioEssays, 23, 508-517.
Tsang, T., Tam, P., Khoo,, P., Jamieson, R.,
Zhou,, S., Ang,, S., Behringer, R. (2001). The
allocation and differentiation of mouse
primordial germ cells. International Journal of
Developmental Biology, 45, 549-555.
Kinder, S., Tsang, T., Tam, P., Wakamiya, M.,
Sasaki, H., Behringer, R., Nagy,, A. (2001). The
organizer of the mouse gastrula is composed of a
dynamic population of progenitor cells for the
axial mesoderm. Development (Cambridge), 128,
3623-3634.