Publications for Patrick Bertolino
Publications for Patrick Bertolino
e Information]</a>
2016
Bolton, H., Zhu, E., Terry, A., Guy, T., Koh, W.,
Tan, S., Power, C., Bertolino, P., Lahl, K.,
Sparwasser, T., Shklovskaya, E., Fazekas de St
Groth, B. (2015). Selective Treg reconstitution
during lymphopenia normalizes DC
costimulation and prevents graft-versus-host
disease. Journal of Clinical Investigation,
125(9), 3627-3641. <a
href="http://dx.doi.org/10.1172/JCI76031">[Mor
e Information]</a>
Vo, M., Holz, L., Wong, Y., English, K.,
Benseler, V., McGuffog, C., Azuma, M.,
McCaughan, G., Bowen, D., Bertolino, P.
(2016). Effector T cell function rather than
survival determines extent and duration of
hepatitis in mice. Journal of Hepatology, 64(6),
1327-1338. <a
href="http://dx.doi.org/10.1016/j.jhep.2016.01.0
40">[More Information]</a>
2015
Powter, E., Coleman, P., Tran, M., Lay, A.,
Bertolino, P., Parton, R., Vadas, M., Gamble, J.
(2015). Caveolae control the anti-inflammatory
phenotype of senescent endothelial cells. Aging
Cell, 14(1), 102-111. <a
href="http://dx.doi.org/10.1111/acel.12270">[M
ore Information]</a>
McCaughan, G., Bertolino, P., Bowen, D.
(2015). Could the morning after liver transplant
be immunologically interesting? Liver
Transplantation, 21(9), 1120-1122. <a
href="http://dx.doi.org/10.1002/lt.24199">[More
Information]</a>
Wong, Y., Tay, S., McCaughan, G., Bowen, D.,
Bertolino, P. (2015). Immune outcomes in the
liver: Is CD8 T cell fate determined by the
environment? Journal of Hepatology, 63(4),
1005-1014. <a
href="http://dx.doi.org/10.1016/j.jhep.2015.05.0
33">[More Information]</a>
Guo, J., McQuillan, J., Yau, B., Tullo, G., Long,
C., Bertolino, P., Roediger, B., Weninger, W.,
Taylor, G., Hunt, N., Ball, H., et al (2015).
IRGM3 Contributes to Immunopathology and Is
Required for Differentiation of Antigen-Specific
Effector CD8 T Cells in Experimental Cerebral
Malaria. Infection and Immunity, 83(4),
1406-1417. <a
href="http://dx.doi.org/10.1128/IAI.02701-14">[
More Information]</a>
Bertolino, P., Bowen, D. (2015). Malaria and the
liver: immunological hide-and-seek or
subversion of immunity from within? Frontiers
in Microbiology, 6(FEB), 1-15. <a
href="http://dx.doi.org/10.3389/fmicb.2015.0004
1">[More Information]</a>
Brockhausen, J., Tay, S., Grzelak, C., Bertolino,
P., Bowen, D., d'Avigdor, W., Teoh, N., Pok, S.,
Shackel, N., Gamble, J., Vadas, M., et al (2015).
miR-181a mediates TGF-β-induced hepatocyte
EMT and is dysregulated in cirrhosis and
hepatocellular cancer. Liver International, 35(1),
240-253. <a
href="http://dx.doi.org/10.1111/liv.12517">[Mor
Sierro, F., Tay, S., Warren, A., Le Couteur, D.,
McCaughan, G., Bowen, D., Bertolino, P.
(2015). Suicidal Emperipolesis: A process
leading to cell-in-cell structures, T cell clearance
and immune homeostasis. Current Molecular
Medicine, 15(9), 819-827. <a
href="http://dx.doi.org/10.2174/1566524015666
151026102143">[More Information]</a>
Le Couteur, D., Tay, S., Solon-Biet, S.,
Bertolino, P., McMahon, A., Cogger, V.,
Colakoglu, F., Warren, A., Holmes, A., Pichaud,
N., Raubenheimer, D., Simpson, S., et al (2015).
The influence of macronutrients on splanchnic
and hepatic lymphocytes in aging mice. Journals
of Gerontology. Series A: Biological Sciences
and Medical Sciences, 70(12), 1499-1507. <a
href="http://dx.doi.org/10.1093/gerona/glu196">
[More Information]</a>
2014
Tay, S., Wong, Y., McDonald, D., Wood, N.,
Roediger, B., Sierro, F., McGuffog, C.,
Alexander, I., Bishop, A., Gamble, J., Weninger,
W., McCaughan, G., Bertolino, P., Bowen, D.
(2014). Antigen expression level threshold tunes
the fate of CD8 T cells during primary hepatic
immune responses. Proceedings of the National
Academy of Sciences of the United States of
America (PNAS), 111(25), E2540-E2549. <a
href="http://dx.doi.org/10.1073/pnas.140667411
1">[More Information]</a>
Bowen, D., Bertolino, P. (2014). Immune
Responses to the Hepatitis C Virus. In I. R.
Mackay, N. R. Rose, B. Diamond, & A.
Davidson (Eds.), Encyclopedia of Medical
Immunology, (pp. 476-486). New York:
Springer.
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu,
B., McDonald, D., McGuffog, C., Meyer, N.,
Alexander, I., Parish, I., Weninger, W., Bishop,
A., Gamble, J., McCaughan, G., Bertolino, P.,
Bowen, D., et al (2014). Intrahepatic activation
of naive CD4+T cells by liver-resident
phagocytic cells. The Journal of Immunology,
193(5), 2087. <a
href="http://dx.doi.org/10.4049/jimmunol.14000
37">[More Information]</a>
Publications for Patrick Bertolino
Bertolino, P., Bowen, D. (2014). Primary T-Cell
Activation in Liver. In I. R. Mackay, N. R.
Rose, B. Diamond, & A. Davidson (Eds.),
Encyclopedia of Medical Immunology, (pp.
899-905). New York: Springer.
Le Couteur, D., Warren, A., Cogger, V.,
Bertolino, P. (2014). Ultrastructure of the Liver
Sinusoid. In I. R. Mackay, N. R. Rose, B.
Diamond, & A. Davidson (Eds.), Encyclopedia
of Medical Immunology, (pp. 1235-1240). New
York: Springer.
2013
Tay, S., Lu, B., Sierro, F., Benseler, V.,
McGuffog, C., Bishop, A., Cowan, P.,
McCaughan, G., Dwyer, K., Bowen, D., et al
(2013). Differential migration of passenger
leukocytes and rapid deletion of naive
alloreactive CD8 T cells after mouse liver
transplantation. Liver Transplantation, 19(11),
1224-1235. <a
href="http://dx.doi.org/10.1002/lt.23720">[More
Information]</a>
Cunningham, E., Tay, S., Wang, C., Rtshiladze,
M., Wang, Z., McGuffog, C., Cubitt, J.,
McCaughan, G., Alexander, I., Bertolino, P.,
Sharland, A., Bowen, D., Bishop, A. (2013).
Gene therapy for tolerance: high-level expression
of donor major histocompatibility complex in the
liver overcomes naive and memory alloresponses
to skin grafts. Transplantation, 95(1), 70-77. <a
href="http://dx.doi.org/10.1097/TP.0b013e31827
8d39a">[More Information]</a>
McCaughan, G., Bowen, D., Bertolino, P.
(2013). Operational tolerance in liver
transplantation: Shall we predict or promote?
Liver Transplantation, 19(9), 933-936. <a
href="http://dx.doi.org/10.1002/lt.23719">[More
Information]</a>
Chowdhury, S., Chen, Y., Yao, T., Ajami, K.,
Wang, X., Popov, Y., Schuppan, D., Bertolino,
P., McCaughan, G., Yu, M., Gorrell, M. (2013).
Regulation of dipeptidyl peptidase 8 and 9
expression in activated lymphocytes and injured
liver. World Journal of Gastroenterology,
19(19), 2883-2893. <a
href="http://dx.doi.org/10.3748/wjg.v19.i19.288
3">[More Information]</a>
2012
Holz, L., Benseler, V., Vo, M., McGuffog, C.,
Van Rooijen, N., McCaughan, G., Bowen, D.,
Bertolino, P. (2012). Naive CD8 T cell activation
by liver bone marrow-derived cells leads to a
"neglected" IL-2(low) Bim(high) phenotype,
poor CTL function and cell death. Journal of
Hepatology, 57(4), 830-836. <a
href="http://dx.doi.org/10.1016/j.jhep.2012.05.0
15">[More Information]</a>
Bishop, A., Bertolino, P., Bowen, D.,
McCaughan, G. (2012). Tolerance in liver
transplantation. Best Practice & Research:
Clinical Gastroenterology, 26(1), 73-84. <a
href="http://dx.doi.org/10.1016/j.bpg.2012.01.00
3">[More Information]</a>
Barbier, L., Tay, S., McGuffog, C., Triccas, J.,
McCaughan, G., Bowen, D., Bertolino, P.
(2012). Two lymph nodes draining the mouse
liver are the preferential site of DC migration and
T cell activation. Journal of Hepatology, 57(2),
352-358. <a
href="http://dx.doi.org/10.1016/j.jhep.2012.03.0
23">[More Information]</a>
2011
Benseler, V., Warren, A., Vo, M., Holz, L., Tay,
S., Le Couteur, D., Breen, E., Allison, A., Van
Rooijen, N., McGuffog, C., Bowen, D.,
McCaughan, G., Bertolino, P., et al (2011).
Hepatocyte entry leads to degradation of
autoreactive CD8 T cells. Proceedings of the
National Academy of Sciences of the United
States of America (PNAS), 108(40),
16735-16740. <a
href="http://dx.doi.org/10.1073/pnas.111225110
8">[More Information]</a>
Benseler, V., Tay, S., Bowen, D., Bertolino, P.
(2011). Role of the Hepatic Parenchyma in Liver
Transplant Tolerance: a Paradigm Revisited.
Digestive Diseases, 29(4), 391-401. <a
href="http://dx.doi.org/10.1159/000329802">[M
ore Information]</a>
Wang, C., Cordoba, S., Hu, M., Bertolino, P.,
Bowen, D., Sharland, A., Allen, R., Alexander,
S., McCaughan, G., Bishop, A. (2011).
Spontaneous acceptance of mouse kidney
allografts is associated with increased Foxp3
expression and differences in the B and T cell
compartments. Transplant Immunology, 24(3),
149-156. <a
href="http://dx.doi.org/10.1016/j.trim.2010.12.00
4">[More Information]</a>
Warren, A., Benseler, V., Cogger, V., Bertolino,
P., Le Couteur, D. (2011). The Impact of
Poloxamer 407 on the Ultrastructure of the Liver
and Evidence for Clearance by Extensive
Endothelial and Kupffer Cell Endocytosis.
Toxicologic Pathology, 39(2), 390-397. <a
href="http://dx.doi.org/10.1177/0192623310394
212">[More Information]</a>
2010
Holz, L., Warren, A., Le Couteur, D., Bowen, D.,
Bertolino, P. (2010). CD8+ T cell tolerance
following antigen recognition on hepatocytes.
Journal of Autoimmunity, 34(1), 15-22. <a
href="http://dx.doi.org/10.1016/j.jaut.2009.08.00
5">[More Information]</a>
Publications for Patrick Bertolino
Viebahn, C., Benseler, V., Holz, L., Elsegood,
C., Vo, M., Bertolino, P., Ganss, R., Yeoh, G.
(2010). Invading macrophages play a major role
in the liver progenitor cell response to chronic
liver injury. Journal of Hepatology, 53(3),
500-507. <a
href="http://dx.doi.org/10.1016/j.jhep.2010.04.0
10">[More Information]</a>
[More Information]</a>
Bertolino, P. (2008). Interleukin-22,
interleukin-17, and other cytokines: a wall is
coming down. Hepatology, 47(1), 345-348. <a
href="http://dx.doi.org/10.1002/hep.22154">[Mo
re Information]</a>
2009
Holz, L., Benseler, V., Bowen, D., Bouillet, P.,
Strasser, A., O'Reilly, L., D'Avigdor, W.,
Bishop, A., McCaughan, G., Bertolino, P.
(2008). Intrahepatic Murine CD8 T-Cell
Activation Associates With a Distinct Phenotype
Leading to Bim-Dependent Death.
Gastroenterology, 135(3), 989-997. <a
href="http://dx.doi.org/10.1053/j.gastro.2008.05.
078">[More Information]</a>
McCaughan, G., Shackel, N., Bertolino, P.,
Bowen, D. (2009). Molecular and cellular
aspects of hepatitis C virus reinfection after liver
transplantation: how the early phase impacts on
outcomes. Transplantation, 87(8), 1105-1111. <a
href="http://dx.doi.org/10.1097/TP.0b013e31819
dfa83">[More Information]</a>
Holz, L., McCaughan, G., Benseler, V.,
Bertolino, P., Bowen, D. (2008). Liver tolerance
and the manipulation of immune outcomes.
Inflammation and Allergy: Drug Targets, 7(1),
6-18. <a
href="http://dx.doi.org/10.2174/1871528087841
65225">[More Information]</a>
Bowen, D., Zekry, A., Bertolino, P., Shackel, N.,
McCaughan, G. (2009). Pathology and
pathogenesis of hepatitis C. In G. Dore, M.
Temple-Smith, A. Lloyd (Eds.), Hepatitis C: An
Expanding Perspective, (pp. 43-75). East
Hawthorn, Victoria: IP Communications.
2007
Holz, L., Bowen, D., Bertolino, P. (2010).
Mechanisms of T cell death in the liver: to Bim
or not to Bim? Digestive Diseases, 28(1), 14-24.
<a
href="http://dx.doi.org/10.1159/000282060">[M
ore Information]</a>
Dahlke, M., Hoogduijn, M., Eggenhofer, E.,
Popp, F., Renner, P., Slowik, P., Rosenauer, A.,
Piso, P., Bertolino, P., Schlitt, H., et al (2009).
Toward MSC in Solid Organ Transplantation:
2008 Position Paper of the MISOT Study Group.
Transplantation, 88, 614-619. <a
href="http://dx.doi.org/10.1097/TP.0b013e3181b
4425a">[More Information]</a>
2008
Allen, K., Mifsud, N., Williamson, R., Bertolino,
P., Hardikar, W. (2008). Cell-mediated rejection
results in allograft loss after liver cell
transplantation. Liver Transplantation, 14(5),
688-694. <a
href="http://dx.doi.org/10.1002/lt.21443">[More
Information]</a>
Bertolino, P., McCaughan, G., Bowen, D.
(2008). Immunological Parameters Influencing
Adaptive Immune Responses to the Hepatitis C
Virus. In Emilio Jirillo (Eds.), Hepatitis C Virus
Disease: Immunobiology and Clinical
Applications, (pp. 39-70). United States:
Springer.
Bertolino, P. (2008). Impaired function of
dendritic cells translocating the liver sinusoids: a
veto effect contributing to intrahepatic tolerance?
European Journal of Immunology, 38(4),
938-941. <a
href="http://dx.doi.org/10.1002/eji.200838296">
Bertolino, P., Bowen, D., Benseler, V. (2007). T
cells in the liver: there is life beyond the
graveyard. Hepatology, 45(6), 1580-1582. <a
href="http://dx.doi.org/10.1002/hep.21786">[Mo
re Information]</a>
Benseler, V., McCaughan, G., Schlitt, H.,
Bishop, A., Bowen, D., Bertolino, P. (2007). The
liver: a special case in transplantation tolerance.
Seminars in Liver Disease, 27(2), 194-213. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17520518">[More Information]</a>
Wu, H., Chen, G., Wyburn, K., Bertolino, P.,
Eris, J., Alexander, S., Sharland, A., Chadban, S.
(2007). TLR4 activation mediates kidney
ischemia/reperfusion injury. Journal of Clinical
Investigation, 117(10), 2847-2859. <a
href="http://dx.doi.org/10.1172/JCI31008">[Mor
e Information]</a>
Bertolino, P., Holz, L. (2007). Toll-like
receptor-3 and the regulation of intrahepatic
immunity: implications for interferon-alpha
therapy. Hepatology (Baltimore Md.), 45(1),
250-251. <a
href="http://dx.doi.org/10.1002/hep.21504">[Mo
re Information]</a>
2006
Wang, C., Cordoba, S., Bertolino, P., Alexander,
S., Wu, M., Allen, R., McCaughan, G., Bishop,
A. (2006). Examination of the immune
mechanism of spontaneous tolerance of renal
allografts in a mouse model. Immunology and
Cell Biology, 84(1), A29-30.
Publications for Patrick Bertolino
Benseler, V., Holz, L., Schlitt, H., Brinkmann,
V., McCaughan, G., Bertolino, P. (2006).
FTY720 treatment leads to sequestration but not
accumulation of antigen-specific CD8+ T cells
activated in lymph nodes.
Dahlke, M., Loi, R., Warren, A., Holz, L., Popp,
F., Weiss, D., Piso, P., Bowen, D., McCaughan,
G., Schlitt, H., Bertolino, P. (2006).
Immune-mediated hepatitis drives low-level
fusion between hepatocytes and adult bone
marrow cells. Journal of Hepatology, 44(2),
334-341. <a
href="http://dx.doi.org/10.1016/j.jhep.2005.07.0
23">[More Information]</a>
Bertolino, P., McCaughan, G., Le Couteur, D.,
Warren, A., Fraser, R., Benseler, V. (2006).
Marked changes of the hepatic sinusoid in a
transgenic mouse model of acute
immune-mediated hepatitis. Journal of
Hepatology, 46, 239-246. <a
href="http://dx.doi.org/10.1016/j.jhep.2006.08.0
22">[More Information]</a>
Warren, A., Le Couteur, D., Fraser, R., Bowen,
D., McCaughan, G., Bertolino, P. (2006). T
lymphocytes interact with hepatocytes through
fenestrations in murine liver sinusoidal
endothelial cells. Hepatology, 44(5), 1182-1190.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17058232">[More Information]</a>
2005
Bertolino, P., Bowen, D., Zen, M., McCaughan,
G. (2005). Autoimmune hepatitis in transgenic
mouse models: what lessons can be learnt? In
H. P. Dienes, U. Leuschner, A. W. Lohse, M. P.
Manns (Eds.), Autoimmune Liver Disease:
Proceedings of the Falk Symposium No. 142,
(pp. 60-72). The Netherlands: Springer.
Bertolino, P., Schrage, A., Bowen, D.,
Klugewitz, K., Ghani, S., Eulenburg, K., Holz,
L., Hogg, N., McCaughan, G., Hamann, A.
(2005). Early intrahepatic antigen-specific
retention of naïve CD8+ T cells is predominantly
ICAM-1/LFA-1 dependent in mice. Hepatology,
42(5), 1063-1071. <a
href="http://dx.doi.org/10.1002/hep.20885">[Mo
re Information]</a>
Cordoba, S., Wang, C., Li, J., Bertolino, P.,
McCaughan, G., Bishop, A. (2005). Examination
of immune mechanisms in a mouse model of
spontaneous renal allograft acceptance.
Immunology and Cell Biology, 83(4
Supplement), A20-A21.
Warren, A., Bertolino, P., Cogger, V., McLean,
A., Fraser, R., Le Couteur, D. (2005). Hepatic
pseudocapillarization in aged mice. Experimental
Gerontology, 40(10), 807-812. <a
href="http://dx.doi.org/10.1016/j.exger.2005.06.
012">[More Information]</a>
Bowen, D., McCaughan, G., Bertolino, P.
(2005). Intrahepatic immunity: a tale of two
sites? Trends in Immunology, 26(10), 512-517.
<a
href="http://dx.doi.org/10.1016/j.it.2005.08.005"
>[More Information]</a>
Sun, J., Tumurbaatar, B., Jia, J., Diao, H.,
Bodola, F., Lemon, S., Tang, W., Bowen, D.,
McCaughan, G., Bertolino, P., et al (2005).
Parenchymal expression of CD86/B7.2
contributes to hepatitis C virus-related liver
injury. Journal of Virology, 79(16),
10730-10739. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16051865">[More Information]</a>
Holz, L., Benseler, V., Gengos, M., Newtown,
R., McCaughan, G., Bertolino, P. (2005).
Phenotype of CD8+ T cells activated in the liver.
Tissue Antigens: immune response genetics,
66(5), 444 (Abstract 279)-444.
Benseler, V., Warren, A., Holz, L., Gengos, M.,
Bowen, D., Le Couteur, D., Schlitt, H.,
McCaughan, G., Bertolino, P. (2005). The liver
promotes antigen-specific retention and rapid
clearance of naive CD8(+) T cells activated in
situ. Tissue Antigens: immune response genetics,
66(5), 359-360.
2004
McCaughan, G., Bertolino, P., Bowen, D., Zen,
M., Holz, L., Davis, T. (2004). The Site Of
Primary T Cell Activation Is A Determinant Of
The Balance Between Intrahepatic Tolerance
And Immunity. Journal of Clinical Investigation,
114(5), 701-712.
2002
Demangel, C., Bertolino, P., Britton, W. (2002).
Autocrine IL-10 impairs dendritic cell
(DC)-derived immune responses to
mycobacterial infection by suppressing DC
trafficking to draining lymph nodes and local
IL-12 production. European Journal of
Immunology, 32(4), 994-1002.
Bowen, D., Warren, A., Davis, T., Hoffmann,
M., McCaughan, G., Fazekas de St Groth, B.,
Bertolino, P. (2002). Cytokine-dependent
bystander hepatitis due to intrahepatic murine
CD8+ T-cell activation by bone marrow-derived
cells. Gastroenterology, 123(4), 1252-1264.
Greenhalgh, C., Bertolino, P., Asa, S., Metcalf,
D., Corbin, J., Adams, T., Davey, H., Nicola, N.,
Hilton, D., Alexander, W. (2002). Growth
enhancement in suppressor of cytokine signaling
Publications for Patrick Bertolino
2 (SOCS-2)-deficient mice is dependent on
signal transducer and activator of transcription
5b (STAT5b). Molecular Endocrinology, 16(6),
1394-1406.
Bertolino, P., McCaughan, G., Bowen, D.
(2002). Role of primary intrahepatic T-cell
activation in the 'liver tolerance effect'.
Immunology and Cell Biology, 80(1), 84-92.
2001
Bertolino, P., Bowen, D., McCaughan, G.,
Fazekas de St Groth, B. (2001). Antigen-Specific
Primary Activation of CD8(+) T Cells Within the
Liver. The Journal of Immunology, 166,
5430-5438.