Publications for Patric Jansson
Publications for Patric Jansson
2016
Seebacher, N., Lane, D., Jansson, P., Richardson,
D. (2016). Glucose Modulation Induces
Lysosome Formation and Increases
Lysosomotropic Drug Sequestration via the
P-Glycoprotein Drug Transporter. The Journal of
Biological Chemistry, 291(8), 3796-3820. <a
href="http://dx.doi.org/10.1074/jbc.M115.68245
0">[More Information]</a>
Gutierrez, E., Seebacher, N., Arzuman, L.,
Kovacevic, Z., Lane, D., Richardson, V., Merlot,
A., Lok, H., Kalinowski, D., Sahni, S., Jansson,
P., Richardson, D. (2016). Lysosomal membrane
stability plays a major role in the cytotoxic
activity of the anti-proliferative agent,
di-2-pyridylketone
4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
Biochimica et Biophysica Acta: international
journal of biochemistry and biophysics, 1863 (7
Pt A), 1665-1681. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
4.017">[More Information]</a>
Merlot, A., Shafie, N., Yu, Y., Richardson, V.,
Jansson, P., Sahni, S., Lane, D., Kovacevic, Z.,
Kalinowski, D., Richardson, D. (2016).
Mechanism of the induction of endoplasmic
reticulum stress by the anti-cancer agent,
di-2-pyridylketone
4,4-dimethyl-3-thiosemicarbazone (Dp44mT):
Activation of PERK/eIF2?, IRE1?, ATF6 and
calmodulin kinase. Biochemical Pharmacology,
109, 27-47. <a
href="http://dx.doi.org/10.1016/j.bcp.2016.04.00
1">[More Information]</a>
Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind,
A., Sharpe, P., Basha, M., Iskander, G., Kumar,
N., Kovacevic, Z., Lane, D., Sahni, S.,
Richardson, D., Kalinowski, D., et al (2016).
Novel Mechanism of Cytotoxicity for the
Selective
Selenosemicarbazone, 2‑Acetylpyridine
4,4-Dimethyl-3selenosemicarbazone (Ap44mSe): Lysosomal
Membrane
Permeabilization. Journal of Medicinal
Chemistry, 59(1), 294-312. <a
href="http://dx.doi.org/10.1021/acs.jmedchem.5b
01399">[More Information]</a>
Kalinowski, D., Stefani, C., Toyokuni, S., Ganz,
T., Anderson, G., Subramaniam, N., Trinder, D.,
Chua, A., Jansson, P., Sahni, S., Lane, D.,
Merlot, A., Kovacevic, Z., Huang, M.,
Richardson, D., et al (2016). Redox cycling
metals: Pedaling their roles in metabolism and
their use in the development of novel
therapeutics. BBA: Biochimica et Biophysica
Acta - Molecular Cell Research, 1893 (4),
727-748. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
1.026">[More Information]</a>
Paluncic, J., Kovacevic, Z., Jansson, P.,
Kalinowski, D., Merlot, A., Huang, M., Lok, H.,
Sahni, S., Lane, D., Richardson, D. (2016).
Roads to melanoma: Key pathways and
emerging players in melanoma progression and
oncogenic signaling. Biochimica et Biophysica
Acta: international journal of biochemistry and
biophysics, 1863 (4), 770-784. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
1.025">[More Information]</a>
Sahni, S., Kovacevic, Z., Kalinowski, D., Huang,
M., Menezes, S., Krishan, S., Lane, D., Jansson,
P., Richardson, D. (2016). Targeting autophagy
in antitumor agent design: Furthering the
'lysosomal love' strategy. Future Medicinal
Chemistry, 8(7), 727-729. <a
href="http://dx.doi.org/10.4155/fmc-2016-0066"
>[More Information]</a>
Seebacher, N., Lane, D., Richardson, D.,
Jansson, P. (2016). Turning the gun on cancer:
Utilizing lysosomal P-glycoprotein as a new
strategy to overcome multi-drug resistance. Free
Radical Biology and Medicine, 96, 432-445. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2016.04.201">[More Information]</a>
Stacy, A., Palanimuthu, D., Bernhardt, P.,
Kalinowski, D., Jansson, P., Richardson, D.
(2016). Zinc(II)-Thiosemicarbazone Complexes
Are Localized to the Lysosomal Compartment
Where They Transmetallate with Copper Ions to
Induce Cytotoxicity. Journal of Medicinal
Chemistry, 59(10), 4965-4984. <a
href="http://dx.doi.org/10.1021/acs.jmedchem.6b
00238">[More Information]</a>
2015
Lane, D., Merlot, A., Huang, M., Bae, D.,
Jansson, P., Sahni, S., Kalinowski, D.,
Richardson, D. (2015). Cellular iron uptake,
trafficking and metabolism: Key molecules and
mechanisms and their roles in disease.
Biochimica et Biophysica Acta. General
Subjects, 1853 (5), 1130-1144. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2015.0
1.021">[More Information]</a>
Jansson, P., Yamagishi, T., Arvind, A.,
Seebacher, N., Gutierrez, E., Stacy, A., Maleki,
S., Sharp, D., Sahni, S., Richardson, D. (2015).
Di-2-pyridylketone
4,4-dimethyl-3-thiosemicarbazone (Dp44mT)
overcomes multidrug resistance by a novel
mechanism involving the hijacking of lysosomal
P-Glycoprotein (Pgp). The Journal of Biological
Chemistry, 290(15), 9588-9603. <a
href="http://dx.doi.org/10.1074/jbc.M114.63128
Publications for Patric Jansson
3">[More Information]</a>
Seebacher, N., Richardson, D., Jansson, P.
(2015). Glucose modulation induces reactive
oxygen species and increases
P-glycoprotein-mediated multidrug resistance to
chemotherapeutics. British Journal of
Pharmacology, 172(10), 2557-2772. <a
href="http://dx.doi.org/10.1111/bph.13079">[Mo
re Information]</a>
Stefani, C., Al-Eisawi, Z., Jansson, P.,
Kalinowski, D., Richardson, D. (2015).
Identification of differential anti-neoplastic
activity of copper bis(thiosemicarbazones) that is
mediated by intracellular reactive oxygen species
generation and lysosomal membrane
permeabilization. Journal of Inorganic
Biochemistry, 152, 20-37. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2015.
08.010">[More Information]</a>
Krishan, S., Jansson, P., Gutierrez, E., Lane, D.,
Richardson, D., Sahni, S. (2015). Iron
metabolism and autophagy: A poorly explored
relationship that has important consequences for
health and disease. Nagoya Journal of Medical
Science, 77, 1-6.
Merlot, A., Kalinowski, D., Kovacevic, Z.,
Jansson, P., Lane, D., Sahni, S., Huang, M.,
Richardson, D. (2015). Making a case for
albumin - a highly promising drug-delivery
system. Future Medicinal Chemistry, 7(5),
553-556. <a
href="http://dx.doi.org/10.4155/fmc.15.15">[Mo
re Information]</a>
Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang,
P., Yue, F., Zheng, M., Huang, M., Jansson, P.,
Richardson, V., Kalinowski, D., Lane, D.,
Merlot, A., Sahni, S., Richardson, D. (2015). The
molecular effect of metastasis suppressors on Src
signaling and tumorigenesis: New therapeutic
targets. Oncotarget, 6(34), 35522-35541. <a
href="http://dx.doi.org/10.18632/oncotarget.584
9">[More Information]</a>
Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D.,
Huang, M., Lane, D., Jansson, P., Liu, G.,
Richardson, V., Sahni, S., Kalinowski, D.,
Kovacevic, Z., Richardson, D. (2015). The
proto-oncogene c-Src and its downstream
signaling pathways are inhibited by the
metastasis suppressor, NDRG1. Oncotarget,
6(11), 8851-8874.
Jansson, P., Kalinowski, D., Lane, D.,
Kovacevic, Z., Seebacher, N., Fouani, L., Sahni,
S., Merlot, A., Richardson, D. (2015). The
renaissance of polypharmacology in the
development of
anti-cancer therapeutics: Inhibition of the "Triad
of Death" in cancer by Di-2-pyridylketone
thiosemicarbazones. Pharmacological Research,
100, 255-260. <a
href="http://dx.doi.org/10.1016/j.phrs.2015.08.0
13">[More Information]</a>
2014
Sahni, S., Merlot, A., Krishnan, S., Jansson, P.,
Richardson, D. (2014). Gene of the month:
BECN1. Journal of Clinical Pathology, 67(8),
656-660. <a
href="http://dx.doi.org/10.1136/jclinpath-2014-2
02356">[More Information]</a>
Fang, B., Kovacevic, Z., Park, K., Kalinowski,
D., Jansson, P., Lane, D., Sahni, S., Richardson,
D. (2014). Molecular Functions of the
Iron-Regulated Metastasis Suppressor, NDRG1,
and its Potential as a Molecular Target for
Cancer Therapy. Biochimica et Biophysica Acta.
Molecular and Cell Biology of Lipids, 1845 (1),
1-19. <a
href="http://dx.doi.org/10.1016/j.bbcan.2013.11.
002">[More Information]</a>
Gutierrez, E., Richardson, D., Jansson, P. (2014).
The Anti-Cancer Agent, Dp44mT, Overcomes
Pro-Survival Autophagy by Two Mechanisms:
Persistent Induction of Autophagosome
Synthesis and Impairment of Lysosomal
Integrity. The Journal of Biological Chemistry,
289(48), 33568-33589. <a
href="http://dx.doi.org/10.1074/jbc.M114.59948
0">[More Information]</a>
Sahni, S., Bae, D., Lane, D., Kovacevic, Z.,
Kalinowski, D., Jansson, P., Richardson, D.
(2014). The metastasis suppressor, N-myc
downstream-regulated gene 1 (NDRG1), inhibits
stress-induced autophagy in cancer cells. The
Journal of Biological Chemistry, 289(14),
9692-9709. <a
href="http://dx.doi.org/10.1074/jbc.M113.52951
1">[More Information]</a>
2013
Stefani, C., Jansson, P., Gutierrez, E., Bernhardt,
P., Richardson, D., Kalinowski, D. (2013). Alkyl
Substituted 2'-Benzoylpyridine
Thiosemicarbazone Chelators with Potent and
Selective Anti-Neoplastic Activity: Novel
Ligands that Limit Methemoglobin Formation.
Journal of Medicinal Chemistry, 56(1), 357-370.
<a
href="http://dx.doi.org/10.1021/jm301691s">[M
ore Information]</a>
Ford, S., Obeidy, P., Lovejoy, D., Bedford, M.,
Nichols, L., Chadwick, C., Tucker, O., Lui, G.,
Kalinowski, D., Jansson, P., Richardson, D., et al
(2013). Deferasirox (ICL670A) effectively
inhibits oesophageal cancer growth in vitro and
in vivo. British Journal of Pharmacology,
168(6), 1316-1328. <a
Publications for Patric Jansson
href="http://dx.doi.org/10.1111/bph.12045">[Mo
re Information]</a>
Sun, J., Zhang, D., Bae, D., Sahni, S., Jansson,
P., Zheng, Y., Zhao, Q., Yue, F., Zheng, M.,
Kovacevic, Z., Richardson, D. (2013). Metastasis
suppressor, NDRG1, mediates its activity
through signaling pathways and molecular
motors. Carcinogenesis, 34(9), 1943-1954. <a
href="http://dx.doi.org/10.1093/carcin/bgt163">[
More Information]</a>
Huang, M., Sivagurunathan, S., Ting, S.,
Jansson, P., Austin, C., Kelly, M., Semsarian, C.,
Zhang, D., Richardson, D. (2013). Molecular and
Functional Alterations in a Mouse Cardiac
Model of Friedreich Ataxia: Activation of the
Integrated Stress Response, eIF2a
Phosphorylation, and the Induction of
Downstream Targets. The American Journal of
Pathology, 183(3), 745-757. <a
href="http://dx.doi.org/10.1016/j.ajpath.2013.05.
032">[More Information]</a>
Stacy, A., Jansson, P., Richardson, D. (2013).
Molecular Pharmacology of ABCG2 and Its Role
in Chemoresistance. Molecular Pharmacology,
84(5), 655-669. <a
href="http://dx.doi.org/10.1124/mol.113.088609
">[More Information]</a>
Yamagishi, T., Sahni, S., Sharp, D., Arvind, A.,
Jansson, P., Richardson, D. (2013).
P-Glycoprotein Mediates Drug Resistance via a
Novel Mechanism Involving Lysosomal
Sequestration. The Journal of Biological
Chemistry, 288(44), 31761-31771. <a
href="http://dx.doi.org/10.1074/jbc.M113.51409
1">[More Information]</a>
Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp,
D., Jansson, P., Kalinowski, D., Kovacevic, Z.,
Lovejoy, D., Richardson, D. (2013). The Iron
Chelator, Deferasirox, as a Novel Strategy for
Cancer Treatment: Oral Activity Against Human
Lung Tumor Xenografts and Molecular
Mechanism of Action. Molecular Pharmacology,
83(1), 179-190. <a
href="http://dx.doi.org/10.1124/mol.112.081893
">[More Information]</a>
Kalinowski, D., Jansson, P., Kovacevic, Z.,
Richardson, D. (2013). The redox-active,
anti-cancer drug Dp44mT inhibits T-cell
activation and CD25 through a copper-dependent
mechanism. Redox Report, 18(2), 48-50. <a
href="http://dx.doi.org/10.1179/1351000213Y.0
000000041">[More Information]</a>
Bae, D., Jansson, P., Huang, M., Kovacevic, Z.,
Kalinowski, D., Lee, C., Sahni, S., Richardson,
D. (2013). The role of NDRG1 in the pathology
and potential treatment of human cancers.
Journal of Clinical Pathology, 66(11), 911-917.
<a
href="http://dx.doi.org/10.1136/jclinpath-2013-2
01692">[More Information]</a>
2012
Quach, P., Gutierrez, E., Basha, M., Kalinowski,
D., Sharpe, P., Lovejoy, D., Bernhardt, P.,
Jansson, P., Richardson, D. (2012).
Methemoglobin Formation by Triapine,
Di-2-pyridylketone-4,4-dimethyl-3thiosemicarbazone (Dp44mT), and Other
Anticancer Thiosemicarbazones: Identification
of Novel Thiosemicarbazones and Therapeutics
That Prevent This Effect. Molecular
Pharmacology, 82(1), 105-114. <a
href="http://dx.doi.org/10.1124/mol.112.078964
">[More Information]</a>
Lovejoy, D., Sharp, D., Seebacher, N., Obeidy,
P., Prichard, T., Stefani, C., Basha, M., Sharpe,
P., Jansson, P., Kalinowski, D., Richardson, D.,
et al (2012). Novel Second-Generation
Di-2-Pyridylketone Thiosemicarbazones Show
Synergism with Standard Chemotherapeutics and
Demonstrate Potent Activity against Lung
Cancer Xenografts after Oral and Intravenous
Administration in Vivo. Journal of Medicinal
Chemistry, 55(16), 7230-7244. <a
href="http://dx.doi.org/10.1021/jm300768u">[M
ore Information]</a>
2011
Lovejoy, D., Jansson, P., Brunk, U., Wong, J.,
Ponka, P., Richardson, D. (2011). Antitumor
Activity of Metal-Chelating Compound Dp44mT
Is Mediated by Formation of a Redox-Active
Copper Complex That Accumulates in
Lysosomes. Cancer Research, 71(17),
5871-5880. <a
href="http://dx.doi.org/10.1158/0008-5472.CAN
-11-1218">[More Information]</a>
Stefani, C., Punnia-Moorthy, G., Lovejoy, D.,
Jansson, P., Kalinowski, D., Sharpe, P.,
Bernhardt, P., Richardson, D. (2011).
Halogenated 2'-Benzoylpyridine
Thiosemicarbazone (XBpT) Chelators with
Potent and Selective Anti-Neoplastic Activity:
Relationship to Intracellular Redox Activity.
Journal of Medicinal Chemistry, 54(19),
6936-6948. <a
href="http://dx.doi.org/10.1021/jm200924c">[M
ore Information]</a>
2010
Jansson, P., Sharpe, P., Bernhardt, P.,
Richardson, D. (2010). Novel
Thiosemicarbazones of the ApT and DpT Series
and Their Copper Complexes: Identification of
Pronounced Redox Activity and Characterization
of Their Antitumor Activity. Journal of
Medicinal Chemistry, 53(15), 5759-5769. <a
Publications for Patric Jansson
href="http://dx.doi.org/10.1021/jm100561b">[M
ore Information]</a>
Jansson, P., Hawkins, C., Lovejoy, D.,
Richardson, D. (2010). The iron complex of
Dp44mT is redox-active and induces hydroxyl
radical formation: An EPR study. Journal of
Inorganic Biochemistry, 104(11), 1224-1228. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2010.
07.012">[More Information]</a>
2009
Richardson, D., Kalinowski, D., Lau, S., Jansson,
P., Lovejoy, D. (2009). Cancer cell iron
metabolism and the development of potent iron
chelators as anti-tumour agents. Biochimica et
Biophysica Acta, 1790 (7), 702-717. <a
href="http://dx.doi.org/10.1016/j.bbagen.2008.04
.003">[More Information]</a>
Mladenka, P., Kalinowski, D., Haskova, P.,
Bobrovova, Z., Hrdina, R., Simunek, T.,
Nachtigal, P., Semecky, V., Vavrova, J.,
Holeckova, M., Jansson, P., Richardson, D., et al
(2009). The Novel Iron Chelator,
2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl
Hydrazone, Reduces Catecholamine-Mediated
Myocardial Toxicity. Chemical Research in
Toxicology, 22(1), 208-217. <a
href="http://dx.doi.org/10.1021/tx800331j">[Mo
re Information]</a>
Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas,
A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe,
P., Bernhardt, P., Richardson, D. (2009).
Thiosemicarbazones from the Old to New: Iron
Chelators That Are More Than Just
Ribonucleotide Reductase Inhibitors. Journal of
Medicinal Chemistry, 52(17), 5271-5294. <a
href="http://dx.doi.org/10.1021/jm900552r">[M
ore Information]</a>
2005
Jansson, P., Del Castillo, U., Lindqvist, C.,
Nordstrom, T. (2005). Effects of iron on Vitamin
C/copper-induced hydroxyl radical generation in
bicarbonate-rich water. Free Radical Research,
39(5), 565-570.
Jansson, P., Lindqvist, C., Nordstrom, T. (2005).
Iron prevents ascorbic acid (vitamin C) induced
hydrogen peroxide accumulation in copper
contaminated drinking water. Free Radical
Research, 39(11), 1233-1239.
2004
Jansson, P., Jung, H., Lindqvist, C., Nordstrom,
T. (2004). Oxidative Decomposition of Vitamin
C in Drinking Water. Free Radical Research,
38(8), 855-860.
2003
Jansson, P., Asplund, K., Makela, J., Lindqvist,
C., Nordstrom, T. (2003). Vitamin C (Ascorbic
Acid) Induced Hydroxyl Radical Formation in
Copper Contaminated Household Drinking
Water: Role of Bicarbonate Concentration. Free
Radical Research, 37(8), 901-905.