Publications for Nicholas Hunt
Publications for Nicholas Hunt
2016
Too, L., McGregor, I., Baxter, A., Hunt, N.
(2016). Altered behaviour and cognitive function
following combined deletion of Toll-like
receptors 2 and 4 in mice. Behavioural Brain
Research, 303, 1-8. <a
href="http://dx.doi.org/10.1016/j.bbr.2016.01.02
4">[More Information]</a>
Too, L., Mitchell, A., McGregor, I., Hunt, N.
(2016). Antibody-induced neutrophil depletion
prior to the onset of pneumococcal meningitis
influences long-term neurological complications
in mice. Brain, Behavior, and Immunity, in press.
<a
href="http://dx.doi.org/10.1016/j.bbi.2016.01.02
1">[More Information]</a>
Jortzik, E., Zocher, K., Isernhagen, A., Mailu, B.,
Rahlfs, S., Viola, G., Wittlin, S., Hunt, N.,
Ihmels, H., Becker, K. (2016).
Benzo[b]quinolizinium derivatives have a strong
antimalarial activity and inhibit indoleamine
dioxygenase. Antimicrobial Agents and
Chemotherapy, 60(1), 115-125. <a
href="http://dx.doi.org/10.1128/AAC.01066-15"
>[More Information]</a>
Yau, B., Mitchell, A., Too, L., Ball, H., Hunt, N.
(2016). Interferon-?-induced nitric oxide
synthase-2 contributes to blood/brain barrier
dysfunction and acute mortality in experimental
streptococcus pneumoniae meningitis. Journal of
Interferon and Cytokine Research, 36(2), 86-99.
<a
href="http://dx.doi.org/10.1089/jir.2015.0078">[
More Information]</a>
Bakmiwewa, S., Weiser, S., Grey, M., Heng, B.,
Guillemin, G., Hunt, N., Ball, H. (2016).
Synergistic induction of CXCL10 by
interferon-gamma and lymphotoxin-alpha in
astrocytes: Possible role in cerebral malaria.
Cytokine, 78, 79-86. <a
href="http://dx.doi.org/10.1016/j.cyto.2015.11.0
24">[More Information]</a>
2015
Bakmiwewa, S., Heng, B., Guillemin, G., Ball,
H., Hunt, N. (2015). An effective, low-cost
method for achieving and maintaining hypoxia
during cell culture studies. BioTechniques, 59(4),
223-229. <a
href="http://dx.doi.org/10.2144/000114341">[M
ore Information]</a>
Hunt, N., Rodriguez, M., Waters, K.,
Machaalani, R. (2015). Changes in orexin
(hypocretin) neuronal expression with normal
aging in the human hypothalamus. Neurobiology
of Aging, 36(1), 292-300. <a
href="http://dx.doi.org/10.1016/j.neurobiolaging.
2014.08.010">[More Information]</a>
Hunt, N., Waters, K., Rodriguez, M.,
Machaalani, R. (2015). Decreased orexin
(hypocretin) immunoreactivity in the
hypothalamus and pontine nuclei in sudden
infant death syndrome. Acta Neuropathologica,
130(2), 185-198. <a
href="http://dx.doi.org/10.1007/s00401-015-143
7-9">[More Information]</a>
Lam, Y., Ha, C., Hoffmann, J., Oscarsson, J.,
Dinudom, A., Mather, T., Cook, D., Hunt, N.,
Caterson, I., Holmes, A., Storlien, L. (2015).
Effects of dietary fat profile on gut permeability
and microbiota and their relationships with
metabolic changes in mice. Obesity, 23(7),
1429-1439. <a
href="http://dx.doi.org/10.1002/oby.21122">[Mo
re Information]</a>
Guo, J., McQuillan, J., Yau, B., Tullo, G., Long,
C., Bertolino, P., Roediger, B., Weninger, W.,
Taylor, G., Hunt, N., Ball, H., et al (2015).
IRGM3 Contributes to Immunopathology and Is
Required for Differentiation of Antigen-Specific
Effector CD8 T Cells in Experimental Cerebral
Malaria. Infection and Immunity, 83(4),
1406-1417. <a
href="http://dx.doi.org/10.1128/IAI.02701-14">[
More Information]</a>
Hackett, M., Aitken, J., El Assaad, F.,
McQuillan, J., Carter, E., Ball, H., Tobin, M.,
Paterson, D., De Jonge, M., Siegele, R., Grau,
G., Hunt, N., Lay, P., et al (2015). Mechanisms
of murine cerebral malaria: Multimodal imaging
of altered cerebral metabolism and protein
oxidation at hemorrhage sites. Science Advances,
6(4), 7-16. <a
href="http://dx.doi.org/10.1126/sciadv.1500911"
>[More Information]</a>
Vidal, C., Li, W., Nanan, B., Lim, C., Guillemin,
G., Ball, H., Hunt, N., Nanan, R., Duque, G.
(2015). The kynurenine pathway of tryptophan
degradation is activated during
osteoblastogenesis. Stem Cells, 33(1), 111-121.
<a
href="http://dx.doi.org/10.1002/stem.1836">[Mo
re Information]</a>
2014
Too, L., Ball, H., McGregor, I., Hunt, N. (2014).
A novel automated test battery reveals enduring
behavioural alterations and cognitive
impairments in survivors of murine
pneumococcal meningitis. Brain, Behavior, and
Immunity, 35, 107-124. <a
href="http://dx.doi.org/10.1016/j.bbi.2013.09.00
7">[More Information]</a>
Khaw, L., Ball, H., Mitchell, A., Grau, G.,
Publications for Nicholas Hunt
Stocker, R., Golenser, J., Hunt, N. (2014). Brain
endothelial cells increase the proliferation of
Plasmodium falciparum through production of
soluble factors. Experimental Parasitology,
145(1), 34-41. <a
href="http://dx.doi.org/10.1016/j.exppara.2014.0
7.002">[More Information]</a>
Hunt, N., Ball, H., Hansen, A., Khaw, L., Guo,
J., Bakmiwewa, S., Mitchell, A., Combes, V.,
Grau, G. (2014). Cerebral malaria:
gamma-interferon redux. Frontiers in Cellular
and Infection Microbiology, 4, 1-12. <a
href="http://dx.doi.org/10.3389/fcimb.2014.0011
3">[More Information]</a>
Grau, G., Hunt, N. (2014). Cytokines and Some
of Their Effector Mechanisms in Cerebral
Malaria Pathogenesis. In M. Hommel and P. G.
Kremsner (Eds.), Encyclopedia of Malaria, (pp.
1-11). New York: Springer. <a
href="http://dx.doi.org/10.1007/978-1-4614-875
7-9_94-1">[More Information]</a>
Too, L., Mitchell, A., Yau, B., Ball, H.,
McGregor, I., Hunt, N. (2014). Interleukin-18
deficiency and its long-term behavioural and
cognitive impacts in a murine model of
pneumococcal meningitis. Behavioural Brain
Research, 263, 176-189. <a
href="http://dx.doi.org/10.1016/j.bbr.2014.01.03
5">[More Information]</a>
El Assaad, F., Wheway, J., Hunt, N., Grau, G.,
Combes, V. (2014). Production, fate and
pathogenicity of plasma microparticles in murine
cerebral malaria. PLoS Pathogens, 10(3), 1-14.
<a
href="http://dx.doi.org/10.1371/journal.ppat.100
3839">[More Information]</a>
href="http://dx.doi.org/10.1016/j.bbrc.2014.05.0
54">[More Information]</a>
Too, L., McQuillan, J., Ball, H., Kanai, M.,
Nakamura, T., Funakoshi, H., McGregor, I.,
Hunt, N. (2014). The kynurenine pathway
contributes to long-term neuropsychological
changes in experimental pneumococcal
meningitis. Behavioural Brain Research, 270,
179-195. <a
href="http://dx.doi.org/10.1016/j.bbr.2014.05.01
8">[More Information]</a>
Too, L., Ball, H., McGregor, I., Hunt, N. (2014).
The pro-inflammatory cytokine
interferon-gamma is an important driver of
neuropathology and behavioural sequelae in
experimental pneumococcal meningitis. Brain,
Behavior, and Immunity, 40, 252-268. <a
href="http://dx.doi.org/10.1016/j.bbi.2014.02.02
0">[More Information]</a>
Guiguemde, W., Hunt, N., Guo, J., Marciano, A.,
Haynes, R., Clark, J., Guy, R., Golenser, J.
(2014). Treatment of murine cerebral malaria by
artemisone in combination with conventional
antimalarial drugs: antiplasmodial effects and
immune responses. Antimicrobial Agents and
Chemotherapy, 58(8), 4745-4754. <a
href="http://dx.doi.org/10.1128/AAC.01553-13"
>[More Information]</a>
Ball, H., Jusof, F., Bakmiwewa, S., Hunt, N.,
Yuasa, H. (2014). Tryptophan-catabolizing
enzymes - party of three. Frontiers in
Immunology, 5, 1-10. <a
href="http://dx.doi.org/10.3389/fimmu.2014.004
85">[More Information]</a>
2013
Pai, S., Qin, J., Cavanagh, L., Mitchell, A.,
El-Assaad, F., Jain, R., Combes, V., Hunt, N.,
Grau, G., Weninger, W. (2014). Real-Time
Imaging Reveals the Dynamics of Leukocyte
Behaviour during Experimental Cerebral Malaria
Pathogenesis. PLoS Pathogens, 10(7), 1-17. <a
href="http://dx.doi.org/10.1371/journal.ppat.100
4236">[More Information]</a>
El-Assaad, F., Wheway, J., Mitchell, A., Lou, J.,
Hunt, N., Combes, V., Grau, G. (2013).
Cytoadherence of Plasmodium berghei-infected
red blood cells to murine brain and lung
microvascular endothelial cells in vitro. Infection
and Immunity, 81(11), 3984-3991. <a
href="http://dx.doi.org/10.1128/IAI.00428-13">[
More Information]</a>
Conroy, T., Guo, J., Elias, N., Cergol, K., Gut, J.,
Legac, J., Khatoon, L., Liu, Y., McGowan, S.,
Rosenthal, P., Hunt, N., Payne, R. (2014).
Synthesis of gallinamide A analogues as potent
falcipain inhibitors and antimalarials. Journal of
Medicinal Chemistry, 57(24), 10557-10563. <a
href="http://dx.doi.org/10.1021/jm501439w">[
More Information]</a>
Machaalani, R., Hunt, N., Waters, K. (2013).
Effects of changes in energy homeostasis and
exposure of noxious insults on the expression of
orexin (hypocretin) and its receptors in the brain.
Brain Research, 1526, 102-122. <a
href="http://dx.doi.org/10.1016/j.brainres.2013.0
6.035">[More Information]</a>
Aitken, J., Austin, C., Hunt, N., Ball, H., Lay, P.
(2014). The Fe-heme structure of
met-indoleamine 2,3-dioxygenase-2 determined
by X-ray absorption fine structure. Biochemical
and Biophysical Research Communications,
450(1), 25-29. <a
Khaw, L., Ball, H., Golenser, J., Combes, V.,
Grau, G., Wheway, J., Mitchell, A., Hunt, N.
(2013). Endothelial Cells Potentiate Interferon-γ
Production in a Novel Tripartite Culture Model
of Human Cerebral Malaria. PloS One, 8(7),
1-13. <a
href="http://dx.doi.org/10.1371/journal.pone.006
Publications for Nicholas Hunt
9521">[More Information]</a>
Jusof, F., Khaw, L., Ball, H., Hunt, N. (2013).
Improved spectrophotometric human
interferon-gamma bioassay. Journal of
Immunological Methods, 394(1), 115-120. <a
href="http://dx.doi.org/10.1016/j.jim.2013.05.01
1">[More Information]</a>
Fatokun, A., Hunt, N., Ball, H. (2013).
Indoleamine 2,3-dioxygenase 2 (IDO2) and the
kynurenine pathway: characteristics and potential
roles in health and disease. Amino Acids, 45(6),
1319-1329. <a
href="http://dx.doi.org/10.1007/s00726-013-160
2-1">[More Information]</a>
Lee, J., Siegele, R., Pastuovic, Z., Hackett, M.,
Hunt, N., Grau, G., Cohen, D., Lay, P. (2013).
Light and heavy ion beam analysis of thin
biological sections. Nuclear Instruments and
Methods in Physics Research. Section B, 306,
129-133. <a
href="http://dx.doi.org/10.1016/j.nimb.2012.11.0
45">[More Information]</a>
Golenser, J., Hunt, N. (2013). Neglected Aspects
of Drug Discovery -Microbiological Aspects.
Current Clinical Pharmacology, 8(1), 73-80. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=22946866">[More Information]</a>
Hunt, N., Waters, K., Machaalani, R. (2013).
Orexin receptors in the developing piglet
hypothalamus, and effects of nicotine and
intermittent hypercapnic hypoxia exposures.
Brain Research, 1508, 73-82. <a
href="http://dx.doi.org/10.1016/j.brainres.2013.0
3.003">[More Information]</a>
2012
Hackett, M., Lee, J., El Assaad, F., McQuillan,
J., Carter, E., Grau, G., Hunt, N., Lay, P. (2012).
FTIR imaging of brain tissue reveals crystalline
creatine deposits are an ex vivo marker of
localized ischemia during murine cerebral
malaria: General implications for disease
neurochemistry. ACS Chemical Neuroscience,
3(12), 1017-1024. <a
href="http://dx.doi.org/10.1021/cn300093g">[M
ore Information]</a>
Bakmiwewa, S., Fatokun, A., Tran, A., Payne,
R., Hunt, N., Ball, H. (2012). Identification of
selective inhibitors of indoleamine
2,3-dioxygenase 2. Bioorganic & Medicinal
Chemistry Letters, 22(24), 7641-7646. <a
href="http://dx.doi.org/10.1016/j.bmcl.2012.10.0
10">[More Information]</a>
Lam, Y., Ha, C., Campbell, C., Mitchell, A.,
Dinudom, A., Oscarsson, J., Cook, D., Hunt, N.,
Caterson, I., Holmes, A., Storlien, L. (2012).
Increased Gut Permeability and Microbiota
Change Associate with Mesenteric Fat
Inflammation and Metabolic Dysfunction in
Diet-induced Obese Mice. PloS One, 7(3), 1-10.
<a
href="http://dx.doi.org/10.1371/journal.pone.003
4233">[More Information]</a>
Mitchell, A., Yau, B., McQuillan, J., Ball, H.,
Too, L., Abtin, A., Hertzog, P., Leib, S., Jones,
C., Gerega, S., Weninger, W., Hunt, N. (2012).
Inflammasome-Dependent IFN-y Drives
Pathogenesis in Streptococcus pneumoniae
Meningitis. The Journal of Immunology,
189(10), 4970-4980. <a
href="http://dx.doi.org/10.4049/jimmunol.12016
87">[More Information]</a>
Guo, J., Guiduemde, A., Bentura-Marciano, A.,
Clark, J., Haynes, R., Chan, W., Wong, H., Hunt,
N., Guy, K., Golenser, J. (2012). Synthesis of
Artemiside and Its Effects in Combination with
Conventional Drugs Against Severe Murine
Malaria. Antimicrobial Agents and
Chemotherapy, 56(1), 163-173. <a
href="http://dx.doi.org/10.1128/AAC.05006-11"
>[More Information]</a>
Combes, V., Guillemin, G., Chan-Ling, T., Hunt,
N., Grau, G. (2012). The crossroads of
neuroinflammation in infectious diseases:
endothelial cells and astrocytes. Trends in
Parasitology, 28(8), 311-319. <a
href="http://dx.doi.org/10.1016/j.pt.2012.05.008
">[More Information]</a>
2011
Hackett, M., McQuillan, J., El Assaad, F.,
Aitken, J., Levina, A., Cohen, D., Siegele, R.,
Carter, E., Grau, G., Hunt, N., Lay, P. (2011).
Chemical alterations to murine brain tissue
induced by formalin fixation: implications for
biospectroscopic imaging and mapping studies of
disease pathogenesis. The Analyst, 136(14),
2941-2952. <a
href="http://dx.doi.org/10.1039/c0an00269k">[
More Information]</a>
Hempel, C., Combes, V., Hunt, N., Kurtzhals, J.,
Grau, G. (2011). CNS Hypoxia Is More
Pronounced in Murine Cerebral than
Noncerebral Malaria and is Reversed by
Erythropoietin. The American Journal of
Pathology, 179(4), 1939-1950. <a
href="http://dx.doi.org/10.1016/j.ajpath.2011.06.
027">[More Information]</a>
McQuillan, J., Mitchell, A., Ho, Y., Combes, V.,
Ball, H., Golenser, J., Grau, G., Hunt, N. (2011).
Coincident parasite and CD8 T cell sequestration
is required for development of experimental
cerebral malaria. International Journal for
Parasitology, 41(2), 155-163. <a
href="http://dx.doi.org/10.1016/j.ijpara.2010.08.
003">[More Information]</a>
Publications for Nicholas Hunt
El Assaad, F., Hempel, C., Combes, V., Mitchell,
A., Ball, H., Kurtzhals, J., Hunt, N., Mathys, J.,
Grau, G. (2011). Differential MicroRNA
Expression in Experimental Cerebral and
Noncerebral Malaria. Infection and Immunity,
79(6), 2379-2384. <a
href="http://dx.doi.org/10.1128/IAI.01136-10">[
More Information]</a>
Bao, B., Carr, E., Xu, Y., Hunt, N. (2011).
Gp91(phox) contributes to the development of
experimental inflammatory bowel disease.
Immunology and Cell Biology, 89(8), 853-860.
<a
href="http://dx.doi.org/10.1038/icb.2011.4">[Mo
re Information]</a>
Hackett, M., Siegele, R., El Assaad, F.,
McQuillan, J., Aitken, J., Carter, E., Grau, G.,
Hunt, N., Cohen, D., Lay, P. (2011).
Investigation of the mouse cerebellum using
STIM and μ-PIXE spectrometric and FTIR
spectroscopic mapping and imaging. Nuclear
Instruments and Methods in Physics Research.
Section B, 269(20), 2260-2263. <a
href="http://dx.doi.org/10.1016/j.nimb.2011.02.0
34">[More Information]</a>
Ampawong, S., Combes, V., Hunt, N., Radford,
J., Chan-Ling, T., Pongponratn, E., Grau, G.
(2011). Quantitation of brain edema and
localisation of aquaporin 4 expression in relation
to susceptibility to experimental cerebral malaria.
International Journal of Clinical and
Experimental Pathology, 4(6), 566-574. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=21904632">[More Information]</a>
Hunt, N. (2011). Redox pioneer: professor
Roland Stocker. Antioxidants & Redox
Signaling, 15(12), 3101-3105. <a
href="http://dx.doi.org/10.1089/ars.2010.3842">
[More Information]</a>
Hee, L., Dinudom, A., Mitchell, A., Grau, G.,
Cook, D., Hunt, N., Ball, H. (2011). Reduced
activity of the epithelial sodium channel in
malaria-induced pulmonary oedema in mice.
International Journal for Parasitology, 41(1),
81-88. <a
href="http://dx.doi.org/10.1016/j.ijpara.2010.07.
013">[More Information]</a>
Lam, Y., Mitchell, A., Holmes, A., Denyer, G.,
Gummesson, A., Caterson, I., Hunt, N., Storlien,
L. (2011). Role of the Gut in Visceral Fat
Inflammation and Metabolic Disorders. Obesity,
19(11), 2113-2120. <a
href="http://dx.doi.org/10.1038/oby.2011.68">[
More Information]</a>
Conroy, T., Guo, J., Linington, R., Hunt, N.,
Payne, R. (2011). Total synthesis,
Stereochemical Assignment, and Antimalarial
Activity of Gallinamide A. Chemistry: A
European Journal, 17(48), 13544-13552. <a
href="http://dx.doi.org/10.1002/chem.201102538
">[More Information]</a>
2010
Yuasa, H., Ball, H., Austin, C., Hunt, N. (2010).
1-L-methyltryptophan is a more effective
inhibitor of vertebrate IDO2 enzymes than
1-D-methyltryptophan. Comparative
Biochemistry and Physiology. Part B:
Biochemistry and Molecular Biology, 157(1),
10-15. <a
href="http://dx.doi.org/10.1016/j.cbpb.2010.04.0
06">[More Information]</a>
Waknine, J., Hunt, N., Bentura-Marciano, A.,
McQuillan, J., Chan, H., Chan, W., Barenholz,
Y., Haynes, R., Golenser, J. (2010). Artemisone
effective against murine cerebral
malaria. Malaria Journal, 9(227), 1-15. <a
href="http://dx.doi.org/10.1186/1475-2875-9-22
7">[More Information]</a>
Austin, C., Mailu, B., Maghzal, G.,
Sanchez-Perez, A., Rahlfs, S., Zocher, K., Yuasa,
H., Arthur, J., Becker, K., Stocker, R., Hunt, N.,
Ball, H. (2010). Biochemical characteristics and
inhibitor selectivity of mouse indoleamine
2,3-dioxygenase-2. Amino Acids, 39(2), 565-578.
<a
href="http://dx.doi.org/10.1007/s00726-010-047
5-9">[More Information]</a>
Hackett, M., Lay, P., Carter, E., Hunt, N., Grau,
G., Gottlieb, D. (2010). Classification of
biological samples using spectroscopic analysis.
Patent No. WO2009AU01423 20091030.
Wang, Y., Liu, H., McKenzie, G., Witting, P.,
Stasch, J., Hahn, M., Changsirivathanathamrong,
D., Wu, B., Ball, H., Thomas, S., Celermajer, D.,
Hunt, N., Stocker, R., et al (2010). Kynurenine is
an endothelium-derived relaxing factor produced
during inflammation. Nature Medicine, 16(3),
279-285. <a
href="http://dx.doi.org/10.1038/nm.2092">[Mor
e Information]</a>
Combes, V., El-Assaad, F., Faille, D., Jambou,
R., Hunt, N., Grau, G. (2010). Microvesiculation
and cell interactions at the brain-endothelial
interface in cerebral malaria pathogenesis.
Progress in Neurobiology, 91(2), 140-151. <a
href="http://dx.doi.org/10.1016/j.pneurobio.2010
.01.007">[More Information]</a>
Waknine, J., McQuillan, J., Hunt, N., Ginsburg,
H., Golenser, J. (2010). Modulation of cerebral
malaria by fasudil and other immune-modifying
compounds. Experimental Parasitology, 125(2),
141-146. <a
href="http://dx.doi.org/10.1016/j.exppara.2010.0
1.005">[More Information]</a>
Publications for Nicholas Hunt
Hunt, N., Grau, G., Engwerda, C., Barnum, S.,
van der Heyde, H., Hansen, D., Schofield, L.,
Golenser, J. (2010). Murine cerebral malaria: the
whole story. Trends in Parasitology, 26(6),
272-4. <a
href="http://dx.doi.org/10.1016/j.pt.2010.03.006
">[More Information]</a>
Mitchell, A., Pradel, L., Chasson, L., Van
Rooijen, N., Grau, G., Hunt, N., Chimini, G.
(2010). Technical Advance: Autofluorescence as
a tool for myeloid cell analysis. Journal of
Leukocyte Biology, 88(3), 597-603. <a
href="http://dx.doi.org/10.1189/jlb.0310184">[
More Information]</a>
Conroy, T., Guo, J., Hunt, N., Payne, R. (2010).
Total synthesis and antimalarial activity of
symplostatin 4. Organic Letters, 12(23),
5576-5579. <a
href="http://dx.doi.org/10.1021/ol1024663">[M
ore Information]</a>
2009
Krimmer, D., Loseli, M., Hughes, M., Oliver, B.,
Moir, L., Hunt, N., Black, J., Burgess, J. (2009).
CD40 and OX40 ligand are differentially
regulated on asthmatic airway smooth muscle.
Allergy, 64, 1074-1082. <a
href="http://dx.doi.org/10.1111/j.1398-9995.200
9.01959.x">[More Information]</a>
Yuasa, H., Ball, H., Ho, Y., Austin, C.,
Whittington, C., Belov, K., Maghzal, G., Jermiin,
L., Hunt, N. (2009). Characterization and
evolution of vertebrate indoleamine 2,
3-dioxygenases (IDOs) from monotremes and
marsupials. Comparative Biochemistry and
Physiology. Part B: Biochemistry and Molecular
Biology, 153(2), 137-144. <a
href="http://dx.doi.org/10.1016/j.cbpb.2009.02.0
02">[More Information]</a>
Miu, J., Ball, H., Mellor, A., Hunt, N. (2009).
Effect of indoleamine dioxygenase-1 deficiency
and kynurenine pathway inhibition on murine
cerebral malaria. International Journal for
Parasitology, 39(3), 363-370. <a
href="http://dx.doi.org/10.1016/j.ijpara.2008.10.
005">[More Information]</a>
2008
Togbe, D., de Sousa, P., Fauconnier, M.,
Boissay, V., Fick, L., Scheu, S., Pfeffer, K.,
Menard, R., Grau, G., Doan, B., Hansen, A.,
Ball, H., Hunt, N., et al (2008). Both functional
LTbeta receptor and TNF receptor 2 are required
for the development of experimental cerebral
malaria. PloS One, 3(7), e2608-1-e2608-12. <a
href="http://dx.doi.org/10.1371/journal.pone.000
2608">[More Information]</a>
Miu, J., Mitchell, A., Muller, M., Carter, S.,
Manders, P., McQuillan, J., Saunders, B., Ball,
H., Lu, B., Campbell, I., Hunt, N. (2008).
Chemokine gene expression during fatal murine
cerebral malaria and protection due to CXCR3
deficiency. The Journal of Immunology, 180(2),
1217-1230. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18178862">[More Information]</a>
Belnoue, E., Potter, S., Rosa, D., Mauduit, M.,
Gruner, A., Kayibanda, M., Mitchell, A., Hunt,
N., Renia, L. (2008). Control of pathogenic
CD8+ T cell migration to the brain by
IFN-gamma during experimental cerebral
malaria. Parasite Immunology, 30(10), 544-553.
<a
href="http://dx.doi.org/10.1111/j.1365-3024.200
8.01053.x">[More Information]</a>
Maghzal, G., Thomas, S., Hunt, N., Stocker, R.
(2008). Cytochrome b5, Not Superoxide Anion
Radical, Is a Major Reductant of Indoleamine
2,3-Dioxygenase in Human Cells. Journal of
Biological Chemistry, 283(18), 12014-12025. <a
href="http://dx.doi.org/10.1074/jbc.M710266200
">[More Information]</a>
Burgess, J., Lee, J., Ge, Q., Ramsay, E., Poniris,
M., Parmentier, J., Roth, M., Johnson, P., Hunt,
N., Black, J., Ammit, A. (2008). Dual ERK and
phosphatidylinositol 3-kinase pathways control
airway smooth muscle proliferation: Differences
in asthma. Journal of Cellular Physiology,
216(3), 673-679. <a
href="http://dx.doi.org/10.1002/jcp.21450">[Mo
re Information]</a>
Hunt, N., Mitchell, A., Hee, L., Xu, Y., Ho, Y.,
McQuillan, J., Sanchez-Perez, A., Miu, J.,
Weiser, S., Austin, C., Grau, G., Combes, V.,
Jambou, R., Ball, H. (2008). Early interactions
between malaria-infected
erythrocytes and the innate immune system
determine the course of immune and
immunopathological outcomes. International
Journal for Parasitology, 38(Suppl 1), S23-S24.
<a
href="http://dx.doi.org/10.1016/S0020-7519(07)
00472-9">[More Information]</a>
Ball, H., Yuasa, H., Austin, C., Weiser, S., Hunt,
N. (2008). Indoleamine 2,3-dioxygenase-2; a
new enzyme in the kynurenine pathway. The
International Journal of Biochemistry and Cell
Biology, 41(3), 467-471. <a
href="http://dx.doi.org/10.1016/j.biocel.2008.01.
005">[More Information]</a>
Austin, C., Astelbauer, F., Kosim-Satyaputra, P.,
Ball, H., Willows, R., Jamie, J., Hunt, N. (2008).
Mouse and human indoleamine 2,3-dioxygenase
display some distinct biochemical and structural
properties. Amino Acids, 36(1), 99-106. <a
href="http://dx.doi.org/10.1007/s00726-008-003
Publications for Nicholas Hunt
7-6">[More Information]</a>
Boeuf, P., Tan, A., Romagosa, C., Radford, J.,
Mwapasa, V., Molyneux, M., Meshnick, S.,
Hunt, N., Rogerson, S. (2008). Placental hypoxia
during placental malaria. The Journal of
Infectious Diseases, 197(5), 757-765. <a
href="http://dx.doi.org/10.1086/526521">[More
Information]</a>
Miu, J., Hunt, N., Ball, H. (2008). Predominance
of interferon-related responses in the brain
during murine malaria, as identified by
microarray analysis. Infection and Immunity,
76(5), 1812-1824. <a
href="http://dx.doi.org/10.1128/IAI.01650-07">[
More Information]</a>
Xu, Y., Hunt, N., Bao, B. (2008). The effect of
restraint stress on experimental colitis is
IFN-gamma independent. Journal of
Neuroimmunology, 200, 53-61. <a
href="http://dx.doi.org/10.1016/j.jneuroim.2008.
06.008">[More Information]</a>
Xu, Y., Hunt, N., Bao, B. (2008). The role of
granulocyte macrophage-colony-stimulating
factor in acute intestinal inflammation. Cell
Research, 18, 1220-1229. <a
href="http://dx.doi.org/10.1038/cr.2008.310">[
More Information]</a>
2007
Ball, H., Sanchez-Perez, A., Weiser, S., Austin,
C., Astelbauer, F., Miu, J., McQuillan, J.,
Stocker, R., Jermiin, L., Hunt, N. (2007).
Characterization of an indoleamine
2,3-dioxygenase-like protein found in humans
and mice. Gene, 396(1), 203-213. <a
href="http://dx.doi.org/10.1016/j.gene.2007.04.0
10">[More Information]</a>
Hunt, N., Stocker, R. (2007). Heme moves to
center stage in cerebral malaria. Nature
Medicine, 13(6), 667-669. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17554329">[More Information]</a>
Weiser, S., Miu, J., Ball, H., Hunt, N. (2007).
Interferon-gamma synergises with tumour
necrosis factor and lymphotoxin-alpha to
enhance the mRNA and protein expression of
adhesion molecules in mouse brain endothelial
cells. Cytokine, 37(1), 84-91. <a
href="http://dx.doi.org/10.1016/j.cyto.2007.02.0
21">[More Information]</a>
Xu, Y., Hunt, N., Bao, B. (2007). The correlation
between proinflammatory cytokines,
MAdCAM-1 and cellular infiltration in the
inflamed colon from TNF-alpha gene knockout
mice. Immunology and Cell Biology, 85(8),
633-639. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17768420">[More Information]</a>
2006
Potter, S., Chan-Ling, T., Rosinova, E., Ball, H.,
Mitchell, A., Hunt, N. (2006). A critical role for
Fas-Fas ligand interactions during the late-stage
neuropathological processes of experimental
cerebral malaria. Journal of Neuroimmunology,
173(1-2), 96-107. <a
href="http://dx.doi.org/10.1016/j.jneuroim.2005.
12.004">[More Information]</a>
Hunt, N., Grau, G. (2006). Blood-brain barrier in
parasitic disease. International Journal for
Parasitology, 36(5), 503-504. <a
href="http://dx.doi.org/10.1016/j.ijpara.2006.02.
019">[More Information]</a>
Parekh, S., Bubb, W., Hunt, N., Rae, C. (2006).
Brain metabolic markers reflect susceptibility
status in cytokine gene knockout mice with
murine cerebral malaria. International Journal
for Parasitology, 36(13), 1409-1418. <a
href="http://dx.doi.org/10.1016/j.ijpara.2006.07.
004">[More Information]</a>
Miu, J., Mitchell, A., Ball, H., Hunt, N. (2006).
Chemokines and malarial infection. Current
Immunology Reviews, 2, 331-344.
Golenser, J., McQuillan, J., Hee, L., Mitchell, A.,
Hunt, N. (2006). Conventional and experimental
treatment of cerebral malaria. International
Journal for Parasitology, 36(5), 583-593. <a
href="http://dx.doi.org/10.1016/j.ijpara.2006.02.
009">[More Information]</a>
Golenser, J., Waknine, J., Krugliak, M., Hunt,
N., Grau, G. (2006). Current perspectives on the
mechanism of action of artemisinins.
International Journal for Parasitology, 36(14),
1427-1441. <a
href="http://dx.doi.org/10.1016/j.ijpara.2006.07.
011">[More Information]</a>
Hunt, N., Golenser, J., Chan-Ling, T., Parekh, S.,
Rae, C., Potter, S., Medana, I., Miu, J., Ball, H.
(2006). Immunopathogenesis of cerebral malaria.
International Journal for Parasitology, 36(5),
569-582. <a
href="http://dx.doi.org/10.1016/j.ijpara.2006.02.
016">[More Information]</a>
Potter, S., Chan-Ling, T., Ball, H., Mansour, H.,
Mitchell, A., Maluish, L., Hunt, N. (2006).
Perforin mediated apoptosis of cerebral
microvascular endothelial cells during
experimental cerebral malaria. International
Journal for Parasitology, 36(4), 485-496. <a
href="http://dx.doi.org/10.1016/j.ijpara.2005.12.
005">[More Information]</a>
Golenser, J., Hunt, N. (2006). Probing for
antiparasitic drugs. Mini - Reviews in Medicinal
Publications for Nicholas Hunt
Chemistry, 6(2), 121-2. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16472180">[More Information]</a>
Okada, F., Kobayashi, M., Tanaka, H.,
Kobayashi, T., Tazawa, H., Iuchi, Y., Onuma,
K., Hosokawa, M., Dinauer, M., Hunt, N. (2006).
The role of nicotinamide adenine dinucleotide
phosphate oxidase-derived reactive oxygen
species in the acquisition of metastatic ability of
tumor cells. The American Journal of Pathology,
169(1), 294-302. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16816381">[More Information]</a>
2005
Rae, C., Moussa, C., Griffin, J., Parekh, S.,
Bubb, W., Hunt, N., Balcar, V. (2005). A
metabolomic approach to ionotropic glutamate
receptor subtype function: a nuclear magnetic
resonance in vitro investigation. Journal of
Cerebral Blood Flow and Metabolism, 26(8),
1005-1017. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16395280">[More Information]</a>
Burgess, J., Blake, A., Boustany, S., Johnson, P.,
Armour, C., Black, J., Hunt, N., Hughes, M.
(2005). CD40 and OX40 ligand are increased on
stimulated asthmatic airway smooth muscle.
Journal of Allergy and Clinical Immunology,
115(2), 302-308. <a
href="http://dx.doi.org/10.1016/j.jaci.2004.11.00
4">[More Information]</a>
Combes, V., De Souza, J., Rénia, L., Hunt, N.,
Grau, G. (2005). Cerebral malaria: Which
parasite? Which model? Drug Discovery Today:
Disease Models, 2(2), 141-147. <a
href="http://dx.doi.org/10.1016/j.ddmod.2005.05
.015">[More Information]</a>
Mitchell, A., Hansen, A., Hee, L., Ball, H.,
Potter, S., Walker, J., Hunt, N. (2005). Early
cytokine production is associated with protection
from murine cerebral malaria. Infection and
Immunity. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16113282">[More Information]</a>
Hunt, N., Becker, K., Koncarevic, S. (2005).
Oxidative stress and antioxidant defense in
malarial parasites. In Sherman I (Eds.),
Molecular approaches to malaria, (pp. 365-383).
Washington DC, USA: ASM Press.
Potter, S., Mitchell, A., Cowden, W., Sanni, L.,
Dinauer, M., de Haan, J., Hunt, N. (2005).
Phagocyte-derived reactive oxygen species do
not influence the progression of murine
blood-stage malaria infections. Infection and
Immunity, 73(8), 4941-4947. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16041008">[More Information]</a>
Parekh, S., Moussa, C., Balcar, V., Hunt, N.,
Bubb, W., Rae, C. (2005). Quinolinic acid,
kynurenic acid and dserine stimulate brain
metabolism. 20th Biennial Meeting of the
International Society for
Neurochemistry/European Society for
Neurochemistry, United Kingdom:
Wiley-Blackwell Publishing Ltd.
2004
Rae, C., McQuillan, J., Parekh, S., Bubb, W.,
Weiser, S., Balcar, V., Hansen, A., Ball, H.,
Hunt, N. (2004). Brain Gene Expression,
Metabolism, And Bioenergetics:
Interrelationships In Murine Models Of Cerebral
And Noncerebral Malaria. The F A S E B
Journal, 18(3), 499-510.
Coltel, N., Combes, V., Hunt, N., Grau, G.
(2004). Cerebral Malaria - A Neurovascular
Pathology with Many Riddles Still to be Solved.
Current Neurovascular Research, 1(2), 91-110.
Ball, H., MacDougall, H., McGregor, I., Hunt, N.
(2004). Cyclooxygenase-2 In The Pathogenesis
Of Murine Cerebral Malaria. The Journal of
Infectious Diseases, 189(4), 751-758.
Burgess, J., Carlin, S., Pack, R., Arndt, G., Au,
W., Black, J., Johnson, P., Hunt, N. (2004).
Detection And Characterization Of Ox40 Ligand
Expression In Human Airway Smooth Muscle
Cells: A Possible Role In Asthma? Journal of
Allergy and Clinical Immunology, 113(4), 683-9.
<a
href="http://dx.doi.org/10.1016/j.jaci.2003.12.31
1">[More Information]</a>
Hardy, K., Hunt, N. (2004). Effects Of A
Redox-Active Agent On Lymphocyte Activation
And Early Gene Expression Patterns. Free
Radical Biology and Medicine, 37(10),
1550-1563. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2004.07.020">[More Information]</a>
Hansen, A., Ball, H., Mitchell, A., Miu, J.,
Takikawa, O., Hunt, N. (2004). Increased
Expression Of Indoleamine 2,3-Dioxygenase In
Murine Malaria Infection Is Predominantly
Localised To The Vascular Endothelium.
International Journal for Parasitology, 34(12),
1309-1319.
Ball, H., Hunt, N. (2004). Needle In A Haystack:
Microdissecting The Proteome Of A Tissue.
Amino Acids, 27(1), 1-7. <a
href="http://dx.doi.org/10.1007/s00726-004-010
Publications for Nicholas Hunt
4-6">[More Information]</a>
Rogerson, S., Grau, G., Hunt, N. (2004). The
Microcirculation In Severe Malaria.
Microcirculation, 11(7), 559-576.
2003
Hunt, N., Grau, G. (2003). Cytokines:
accelerators and brakes in the pathogenesis of
cerebral malaria. Trends in Immunology, 24(9),
491-499.
Medana, I., Day, N., Salahifar-Sabet, H.,
Stocker, R., Smythe, G., Bwanaisa, L., Njobvu,
A., Kayira, K., Turner, G., Taylor, T., Hunt, N.
(2003). Metabolites of the Kynurenine pathway
of tryptophan metabolism in the cerebrospinal
fluid of Malawian children with Malaria. The
Journal of Infectious Diseases, 188(6), 844-849.
Lau, A., Leichtweis, S., Hume, P., Mashima, R.,
Hou, J., Chaufour, X., Wilkinson, B., Hunt, N.,
Celermajer, D., Stocker, R. (2003). Probucol
promotes functional reedothelialization in
balloon-injured rabbit aortas. Circulation,
107(15), 2031-2036.
2002
Ball, H., McParland, B., Driussi, C., Hunt, N.
(2002). Isolating vessels from the mouse brain
for gene expression analysis using laser capture
microdissection. Brain Research Protocols, 9(3),
206-213.
Medana, I., Hien, T., Day, N., Phu, N., Mai, N.,
Chu'ong, L., Chau,, T., Taylor, A., Salahifar, H.,
Stocker, R., Hunt, N., et al (2002). The Clinical
Significance of Cerebrospinal Fluid Levels of
Kynurenine Pathway Metabolites and Lactate in
Severe Malaria. The Journal of Infectious
Diseases, 185(5), 650-656.
2001
Thomas, S., Salahifar, H., Mashima, R., Hunt,
N., Richardson, D., Stocker, R. (2001).
Antioxidants Inhibit Indoleamine
2,3-Dioxygenase in IFN-gamma-Activated
Human Macrophages: Posttranslational
Regulation by Pyrrolidine Dithiocarbamate. The
Journal of Immunology, 166, 6332-6340.
Pack, R., Hardy, K., Madigan, M., Hunt, N.
(2001). Differential effects of the antioxidant
a-lipoic acid on the proliferation of
mitogen-stimulated peripheral blood
lymphocytes and leukaemic T cells. Molecular
Immunology, 38(10), 733-745.
Lee, J., Johnson, P., Roth, M., Hunt, N., Black, J.
(2001). ERK activation and mitogenesis in
human airway smooth muscle cells. American
Journal of Physiology: Lung Cellular and
Molecular Physiology, 280.
Hunt, N., Driussi, C., Sai-Kiang, L. (2001).
Haptoglobin and malaria. Redox Report, 6,
389-392.
Sanni, L., Rae, C., Maitland, D., Hunt, N.,
Stocker, R. (2001). Is Ischemia Involved in the
Pathogenesis of Murine Cerebral Malaria? The
American Journal of Pathology, 159, 1105-1112.
Potter, S., Sanni, L., Simasathiansophon, S.,
Hunt, N., Dinauer, M. (2001). Phagocyte-derived
reactive oxygen species and the immunology and
pathology of murine malaria. Redox Report, 6,
200-203.
Medana, I., Chaudhri, G., Chan-Ling, T., Hunt,
N. (2001). The central nervous system in
cerebral
malaria: "innocent bystander" or active
participant in the induction of pathology?
Immunology and Cell Biology, 79, 101-120.
Van Reyk, D., King, N., Hunt, N., Dinauer, M.
(2001). The intracellular oxidation of 2',
7'-dichlorofluorescin in murine T lymphocytes.
Free Radical Biology and Medicine, 30, 82-88.