Publications for James Melrose
Publications for James Melrose
2016
Shu, C., Jackson, M., Smith, M., Smith, S.,
Little, C., Melrose, J., Penm, S., Lord, M.,
Whitelock, J. (2016). Ablation of Perlecan
domain I heparan sulfate reduces progressive
cartilage degradation, synovitis, and osteophyte
size in post-traumatic osteoarthritis. Arthritis &
Rheumatology, 68(4), 868-879. <a
href="http://dx.doi.org/10.1002/art.39529">[Mor
e Information]</a>
Melrose, J., Shu, C., Whitelock, J., Lord, M.
(2016). The cartilage extracellular matrix as a
transient developmental scaffold for growth plate
maturation. Matrix Biology, 52-54, 363-383. <a
href="http://dx.doi.org/10.1016/j.matbio.2016.01
.008">[More Information]</a>
Hayes, A., Hughes, C., Smith, S., Caterson, B.,
Little, C., Melrose, J. (2016). The CS Sulphation
Motifs 4C3, 7D4, 3B3[-]; and Perlecan Identify
Stem Cell Populations and Niches, Activated
Progenitor Cells and Transitional Tissue
Development in the Fetal Human Elbow. Stem
Cells and Development, 25(11), 836-847. <a
href="http://dx.doi.org/10.1089/scd.2016.0054">
[More Information]</a>
Shu, C., Smith, S., Melrose, J. (2016). The
heparan sulphate deficient Hspg2 exon 3 null
mouse displays reduced deposition of
TGF-Beta1 in skin compared to C57BL/6 wild
type mice. Journal of Molecular Histology,
47(3), 365-374. <a
href="http://dx.doi.org/10.1007/s10735-016-967
7-0">[More Information]</a>
2015
and Cats, (pp. 3-7). Iowa: Wiley-Blackwell
Publishing. <a
href="http://dx.doi.org/10.1002/9781118940372.
ch1">[More Information]</a>
Hodges, P., James, G., Blomster, L., Hall, L.,
Schmid, A., Shu, C., Little, C., Melrose, J.
(2015). Multifidus Muscle Changes after Back
Injury Are Characterized by Structural
Remodeling of Muscle, Adipose and Connective
Tissue, but Not Muscle Atrophy: Molecular and
Morphological Evidence. Spine, 40(14),
1057-1071. <a
href="http://dx.doi.org/10.1097/BRS.000000000
0000972">[More Information]</a>
Smith, M., Melrose, J. (2015). Proteoglycans in
Normal and Healing Skin. Advances in Wound
Care, 4(3), 152-173. <a
href="http://dx.doi.org/10.1089/wound.2013.046
4">[More Information]</a>
2014
Hodges, P., James, G., Blomster, L., Hall, L.,
Schmid, A., Shu, C., Little, C., Melrose, J.
(2014). Can Proinflammatory Cytokine Gene
Expression Explain Multifidus Muscle Fiber
Changes After an Intervertebral Disc Lesion?
Spine, 39(13), 1010-1017. <a
href="http://dx.doi.org/10.1097/BRS.000000000
0000318">[More Information]</a>
Hayes, A., Gibson, M., Shu, C., Melrose, J.
(2014). Confocal microscopy demonstrates
association of LTBP-2 in fibrillin-1 microfibrils
and colocalisation with perlecan in the disc cell
pericellular matrix. Tissue and Cell, 46(3),
185-197. <a
href="http://dx.doi.org/10.1016/j.tice.2014.04.00
2">[More Information]</a>
Fingeroth, J., Melrose, J. (2015). "Discogenic"
Pain (Signs Associated With Disc Degeneration
But Without Herniation): Does It Occur? In
James M Fingeroth, William B Thomas (Eds.),
Advances in Intervertebral Disc Disease in Dogs
and Cats, (pp. 127-130). Iowa: Wiley-Blackwell
Publishing. <a
href="http://dx.doi.org/10.1002/9781118940372.
ch14">[More Information]</a>
Lord, M., Chuang, C., Melrose, J., Davies, M.,
Iozzo, R., Whitelock, J. (2014). The role of
vascular-derived perlecan in modulating cell
adhesion, proliferation and growth factor
signaling. Matrix Biology, 35, 112-122. <a
href="http://dx.doi.org/10.1016/j.matbio.2014.01
.016">[More Information]</a>
Farrugia, B., Lord, M., Melrose, J., Whitelock, J.
(2015). Can We Produce Heparin/Heparan
Sulfate Biomimetics Using
Melrose, J., Smith, M., Smith, S., Ravi, V.,
Young, A., Dart, A., Sonnabend, D., Little, C.
(2013). Altered stress induced by partial
transection of the infraspinatus tendon leads to
perlecan (HSPG2) accumulation in an ovine
model of tendinopathy. Tissue and Cell, 45(1),
77-82. <a
href="http://dx.doi.org/10.1016/j.tice.2012.10.00
1">[More Information]</a>
“Mother-Nature�? as the Gold Standard?
Molecules, 20(3), 4254-4276. <a
href="http://dx.doi.org/10.3390/molecules20034
254">[More Information]</a>
Innes, J., Melrose, J. (2015). Embryology,
Innervation, Morphology, Structure, and
Function of the Canine Intervertebral Disc. In
James M Fingeroth, William B Thomas (Eds.),
Advances in Intervertebral Disc Disease in Dogs
2013
Hayes, A., Smith, S., Melrose, J. (2013).
Comparative immunolocalisation of fibrillin-1
and perlecan in the human foetal, and
HS-deficient hspg2 exon 3 null mutant mouse
Publications for James Melrose
intervertebral disc. Histochemistry and Cell
Biology, 139(1), 1-11. <a
href="http://dx.doi.org/10.1007/s00418-012-104
1-1">[More Information]</a>
Shu, C., Smith, S., Little, C., Melrose, J. (2013).
Comparative immunolocalisation of perlecan,
heparan sulphate, fibroblast growth factor-18,
and fibroblast growth factor receptor-3 and their
prospective roles in chondrogenic and osteogenic
development of the human foetal spine.
European Spine Journal, 22(8), 1774-1784. <a
href="http://dx.doi.org/10.1007/s00586-013-268
0-1">[More Information]</a>
Shu, C., Hughes, C., Smith, S., Smith, M.,
Hayes, A., Caterson, B., Little, C., Melrose, J.
(2013). The ovine newborn and human foetal
intervertebral disc contain perlecan and aggrecan
variably substituted with native 7D4 CS
sulphation motif: spatiotemporal
immunolocalisation and co-distribution with
Notch-1 in the human foetal disc.
Glycoconjugate Journal, 30(7), 717-725. <a
href="http://dx.doi.org/10.1007/s10719-013-947
5-9">[More Information]</a>
2012
Brown, S., Melrose, J., Caterson, B., Roughley,
P., Eisenstein, S., Roberts, S. (2012). A
comparative evaluation of the small leucine-rich
proteoglycans of pathological human
intervertebral discs. European Spine Journal,
21(Suppl 2), S154-S159. <a
href="http://dx.doi.org/10.1007/s00586-012-217
9-1">[More Information]</a>
Melrose, J., Isaacs, M., Smith, S., Hughes, C.,
Little, C., Caterson, B., Hayes, A. (2012).
Chondroitin sulphate and heparan sulphate
sulphation motifs and their proteoglycans are
involved in articular cartilage formation during
human foetal knee joint development.
Histochemistry and Cell Biology, 138(3),
461-475. <a
href="http://dx.doi.org/10.1007/s00418-012-096
8-6">[More Information]</a>
Melrose, J., Shu, C., Young, C., Ho, R., Smith,
M., Young, A., Smith, S., Gooden, B., Dart, A.,
Podadera, J., Appleyard, R., Little, C. (2012).
Mechanical destabilization induced by controlled
annular incision of the intervertebral disc
dysregulates metalloproteinase expression and
induces disc degeneration. Spine, 37(1), 18-25.
<a
href="http://dx.doi.org/10.1097/BRS.0b013e318
20cd8d5">[More Information]</a>
Chuang, C., Shahin, K., Lord, M., Melrose, J.,
Doran, P., Whitelock, J. (2012). The cartilage
matrix molecule components produced by human
foetal cartilage rudiment cells within scaffolds
and the role of exogenous growth factors.
Biomaterials, 33(16), 4078-4088. <a
href="http://dx.doi.org/10.1016/j.biomaterials.20
12.02.032">[More Information]</a>
Fuller, E., Smith, M., Little, C., Melrose, J.
(2012). Zonal differences in meniscus matrix
turnover and cytokine response. Osteoarthritis
and Cartilage, 20(1), 49-59. <a
href="http://dx.doi.org/10.1016/j.joca.2011.10.00
2">[More Information]</a>
2011
Hayes, A., Lord, M., Smith, S., Smith, M.,
Whitelock, J., Weiss, A., Melrose, J. (2011).
Colocalization in vivo and association in vitro of
perlecan and elastin. Histochemistry and Cell
Biology, 136, 437-454. <a
href="http://dx.doi.org/10.1007/s00418-011-085
4-7">[More Information]</a>
Hayes, A., Smith, S., Gibson, M., Melrose, J.
(2011). Comparative immunolocalisation of the
elastin fibre associated proteins fibrillin-1,
LTBP2 and MAGP-1 with components of the
collagenous and proteoglycan matrix of the
foetal human Intervertebral Disc. Spine, 36(21),
E1365-1372. <a
href="http://dx.doi.org/10.1097/BRS.0b013e318
21fd23e">[More Information]</a>
Whitelock, J., Melrose, J. (2011). Heparan
sulfate proteoglycans in healthy and diseased
systems. Wiley Interdisciplinary Reviews.
Systems Biology and Medicine, 3(6), 739-751. <a
href="http://dx.doi.org/10.1002/wsbm.149">[Mo
re Information]</a>
Smith, S., Melrose, J. (2011). Podoplanin is
expressed by a sub-population of human foetal
rib and knee joint rudiment chondrocytes. Tissue
and Cell, 43(1), 39-44. <a
href="http://dx.doi.org/10.1016/j.tice.2010.11.00
3">[More Information]</a>
Stanton, H., Melrose, J., Little, C., Fosang, A.
(2011). Proteoglycan degradation by the
ADAMTS family of proteinases. Biochimica et
Biophysica Acta-Molecular Basis of Disease,
1812 (12), 1616-1629. <a
href="http://dx.doi.org/10.1016/j.bbadis.2011.08.
009">[More Information]</a>
2010
Schollum, M., Appleyard, R., Little, C., Melrose,
J. (2010). A Detailed Microscopic Examination
of Alterations in Normal Anular Structure
Induced by Mechanical Destabilization in an
Ovine Model of Disc Degeneration. Spine,
35(22), 1965-1973. <a
href="http://dx.doi.org/10.1097/BRS.0b013e318
1e0f085">[More Information]</a>
Smith, S., Shu, C., Melrose, J. (2010).
Comparative immunolocalisation of perlecan
Publications for James Melrose
with collagen II and aggrecan in human foetal,
newborn and adult ovine joint tissues
demonstrates perlecan as an early developmental
chondrogenic marker. Histochemistry and Cell
Biology, 134(3), 251-263. <a
href="http://dx.doi.org/10.1007/s00418-010-073
0-x">[More Information]</a>
Chuang, C., Lord, M., Melrose, J., Rees, M.,
Knox, S., Freeman, C., Iozzo, R., Whitelock, J.
(2010). Heparan Sulfate-Dependent Signaling of
Fibroblast Growth Factor 18 by
Chondrocyte-Derived Perlecan. Biochemistry,
49(26), 5524-5532. <a
href="http://dx.doi.org/10.1021/bi1005199">[M
ore Information]</a>
Melrose, J., Little, C. (2010).
Immunolocalization of lymphatic vessels in
human fetal knee joint tissues. Connective Tissue
Research, 51(4), 289-305. <a
href="http://dx.doi.org/10.3109/0300820090331
8287">[More Information]</a>
2009
Melrose, J., Burkhardt, D., Taylor, T., Dillon, C.,
Read, R., Cake, M., Little, C. (2009).
Calcification in the ovine intervertebral disc: a
model of hydroxyapatite deposition disease.
European Spine Journal, 18(4), 479-489. <a
href="http://dx.doi.org/10.1007/s00586-008-087
1-y">[More Information]</a>
Melrose, J., Gooden, B., Dart, A., Appleyard, R.,
Little, C. (2009). Dysregulation of
metalloproteinase expression in a mechanical
destabilization model of intervertebral disc
degeneration in sheep. ACSR Spinal Research
Symposium VII.
Smith, S., Whitelock, J., Iozzo, R., Little, C.,
Melrose, J. (2009). Topographical variation in
the distributions of versican, aggrecan and
perlecan in the foetal human spine reflects their
diverse functional roles in spinal development.
Histochemistry and Cell Biology, 132(5),
491-503. <a
href="http://dx.doi.org/10.1007/s00418-009-062
3-z">[More Information]</a>
2008
Whitelock, J., Melrose, J., Iozzo, R. (2008).
Diverse Cell Signaling Events Modulated by
Perlecan. Biochemistry, 47(43), 11174-11183. <a
href="http://dx.doi.org/10.1021/bi8013938">[M
ore Information]</a>
Melrose, J., Fuller, E., Roughley, P., Smith, M.,
Kerr, B., Hughes, C., Caterson, B., Little, C.
(2008). Fragmentation of decorin, biglycan,
lumican and keratocan is elevated in degenerate
human meniscus, knee and hip articular
cartilages compared with age-matched
macroscopically normal and control tissues.
Arthritis Research & Therapy, 10(4), 1-10. <a
href="http://dx.doi.org/10.1186/ar2453">[More
Information]</a>
Cake, M., Melrose, J. (2008). Intervertebral disc
is an alternate tissue source of circulating
C-telopeptide of type II collagen after
menopause or ovariectomy: comment on the
article by Sondergaard et al. Arthritis &
Rheumatology, 58(5), 1560. <a
href="http://dx.doi.org/10.1002/art.23448">[Mor
e Information]</a>
Smith, M., Sakurai, G., Smith, S., Young, A.,
Melrose, J., Stewart, C., Appleyard, R., Peterson,
J., Gilles, R., Dart, A., Sonnabend, D., Little, C.
(2008). Modulation of Aggrecan and ADAMTS
Expression in Ovine Tendinopathy Induced by
Altered Strain. Seminars in Arthritis and
Rheumatism, 58(4), 1055-1066. <a
href="http://dx.doi.org/10.1002/art.23388">[Mor
e Information]</a>
Melrose, J., Hayes, A., Whitelock, J., Little, C.
(2008). Perlecan, the jack of all trades"
proteoglycan of cartilaginous weight-bearing
connective tissues.". BioEssays : news and
reviews in molecular cellular and
developmental biology, 30(5), 457-469. <a
href="http://dx.doi.org/10.1002/bies.20748">[M
ore Information]</a>
Melrose, J., Smith, S., Little, C., Moore, R.,
Vernon-Roberts, B., Fraser, R. (2008). Recent
advances in annular pathobiology provide
insights into rim-lesion mediated intervertebral
disc degeneration and potential new approaches
to annular repair strategies. European Spine
Journal, 17(9), 1131-1148. <a
href="http://dx.doi.org/10.1007/s00586-008-071
2-z">[More Information]</a>
Melrose, J., Smith, S., Fuller, E., Young, A.,
Roughley, P., Dart, A., Little, C. (2008). Spatial
and temporal catabolism of the small leucine
repeat proteoglycans (SLRPs) in an ovine
annular lesion model of experimental
intervertebral disc degeneration has
structure-function implications. World Forum for
Spine Research 2008, Switzerland: AO
Foundation.
Melrose, J., Smith, S., Smith, M., Little, C.
(2008). The use of Histochoice (tmR) for
histological examination of articular and growth
plate cartilages, intervertebral disc and meniscus.
Biotechnic and Histochemistry, 83(1), 47-53. <a
href="http://dx.doi.org/10.1080/1052029080199
0414">[More Information]</a>
Melrose, J., Chuang, C., Whitelock, J. (2008).
Tissue engineering of cartilages using
biomatrices. Journal of Chemical Technology
and Biotechnology, 83, 444-463. <a
href="http://dx.doi.org/10.1002/jctb.1857">[Mor
Publications for James Melrose
e Information]</a>
2007
Melrose, J., Smith, S., Appleyard, R., Little, C.
(2007). Aggrecan, versican and type VI collagen
are components of annular translamellar
crossbridges in the intervertebral disc. European
Spine Journal, Published online: 31 October
2007, 1-11. <a
href="http://dx.doi.org/10.1007/s00586-007-053
8-0">[More Information]</a>
Alini, M., Eisenstein, S., Ito, K., Little, C.,
Kettler, A., Masuda, K., Melrose, J., Ralphs, J.,
Stokes, I., Wilke, H. (2007). Are animal models
useful for studying human disc
disorders/degeneration? European Spine Journal,
Published online: 14 July 2007, 1-18. <a
href="http://dx.doi.org/10.1007/s00586-007-041
4-y">[More Information]</a>
Melrose, J., Smith, S., Fuller, E., Young, A.,
Roughley, P., Dart, A., Little, C. (2007).
Biglycan and fibromodulin fragmentation
correlates with temporal and spatial annular
remodelling in experimentally injured ovine
intervertebral discs. European Spine Journal,
16(12), 2193-2205. <a
href="http://dx.doi.org/10.1007/s00586-007-049
7-5">[More Information]</a>
Young, A., Appleyard, R., Smith, M., Melrose,
J., Little, C. (2007). Dynamic Biomechanics
Correlate With Histopathology in Human Tibial
Cartilage: A Preliminary Study. Clinical
Orthopaedics and Related Research, 462,
212-220. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17496559">[More Information]</a>
2006
Whitelock, J., Melrose, J. (2006). Adhesion of
Cells to Biomaterials. In Metin Akay (Eds.),
Wiley Encyclopedia of Biomedical Engineering.
United States: Wiley-Blackwell Publishing.
Smith, M., Sakurai, A., Smith, S., Young, A.,
Melrose, J., Dart, A., Sonnabend, D., Little, C.
(2006). Altered aggrecan and ADAMTS
expression in overload-induced tendon
pathology. 49th Annual Meeting of the
Orthopaedic Research Society, United states:
Orthopaedic Research Society.
Young, A., McLennan, S., Smith, S., Smith, M.,
Melrose, J., Cake, M., Flannery, C., Sonnabend,
D., Little, C. (2006). Changes in expression and
immunolcalization of proteoglycan 4 / lubricin in
cartilage in an ovine model of early
osteoarthritis. 49th Annual Meeting of the
Orthopaedic Research Society, United states:
Orthopaedic Research Society.
Melrose, J., Whitelock, J. (2006). Extracellular
Matrix. In Metin Akay (Eds.), Wiley
Encyclopedia of Biomedical Engineering. United
States: Wiley-Blackwell Publishing.
Young, A., McLennan, S., Smith, M., Smith, S.,
Cake, M., Read, R., Melrose, J., Sonnabend, D.,
Flannery, C., Little, C. (2006). Proteoglycan 4
downregulation in a sheep meniscectomy model
of early osteoarthritis. Arthritis Research &
Therapy, 8(2), 1-6. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16469119">[More Information]</a>
Melrose, J., Roughley, P., Knox, S., Smith, S.,
Lord, M., Whitelock, J. (2006). The structure,
location and function of perlecan, a prominent
pericellular proteoglycan of foetal, postnatal and
mature hyaline cartilages. Journal of Biological
Chemistry, 281(48), 36905-36914. <a
href="http://dx.doi.org/10.1074/jbc.M608462200
">[More Information]</a>
2005
Melrose, J., Smith, S., Cake, M., Read, R.,
Whitelock, J. (2005). Comparative spatial and
temporal localisation of perlecan, aggrecan and
type I, II and IV collagen in the ovine meniscus:
an ageing study. Histochemistry and Cell
Biology, 124(3-4), 225-235. <a
href="http://dx.doi.org/10.1007/s00418-005-000
5-0">[More Information]</a>
Young, A., Smith, M., Smith, S., Burkhardt, D.,
Cake, M., Melrose, J., Read, R., Ghosh, P.,
Sonnabend, D., Little, C. (2005). Metabolism of
Small Leucine-Rich Proteoglycans in an Ovine
Model of Osteoarthritis. 51st Annual Meeting of
the Orthopaedic Research Society, 30,
1057-1057.
Melrose, J., Smith, S., Cake, M., Read, R.,
Whitelock, J. (2005). Perlecan displays variable
spatial and temporal immunolocalisation patterns
in the articular and growth plate cartilages of the
ovine stifle joint. Histochemistry and Cell
Biology, 123(6), 561-571. <a
href="http://dx.doi.org/10.1007/s00418-005-078
9-y">[More Information]</a>
Knox, S., Fosang, A., Last, K., Melrose, J.,
Whitelock, J. (2005). Perlecan from human
epithelial cells is a hybrid
heparan/chondroitin/keratan sulfate
proteoglycan. FEBS Letters, 579(22), 5019-5023.
<a
href="http://dx.doi.org/10.1016/j.febslet.2005.07.
090">[More Information]</a>
Young, A., Smith, M., Smith, S., Cake, M.,
Ghosh, P., Read, R., Melrose, J., Sonnabend, D.,
Roughley, P., Little, C. (2005). Regional
assessment of articular cartilage gene expression
Publications for James Melrose
and small proteoglycan metabolism in an animal
model of osteoarthritis. Arthritis Research &
Therapy, 7(4), R852-61. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15987487">[More Information]</a>
2004
Melrose, J., Smith, S. (2004). Histochemical
Visualization Of The Cartilage Hyaladherins
Using A Biotinylated Hyaluronan
Oligosaccharide Bioaffinity Probe. Methods in
molecular medicine, 101(1), 65-78.
Melrose, J., Smith, S., Ghosh, P. (2004).
Histological And Immunohistological Studies On
Cartilage. Methods in molecular medicine,
101(1), 39-63.
Melrose, J., Smith, S., Whitelock, J. (2004).
Perlecan Immunolocalizes To Perichondrial
Vessels And Canals In Human Fetal
Cartilaginous Primordia In Early Vascular And
Matrix Remodeling Events Associated With
Diarthrodial Joint Development. Journal of
Histochemistry and Cytochemistry: imaging the
spectrum of cell biology, 52(11), 1405-1413.
2003
Melrose, J., Smith, S., Ghosh, P. (2003).
Assessment of the cellular heterogeneity of the
ovine intervertebral disc: comparison with
synovial fibroblasts and articular chondrocytes.
European Spine Journal, 12(1), 57-65.
Shen, B., Melrose, J., Ghosh, P., Taylor, T.
(2003). Induction of matrix metalloproteinase-2
and -3 activity in ovine nucleus pulposus cells
grown in three-dimensional agarose gel culture
by interleukin-1beta: a potential pathway of disc
degeneration. European Spine Journal, 12(1),
66-75.
Melrose, J., Smith, S., Ghosh, P., Whitelock, J.
(2003). Perlecan, the multidomain heparan
sulfate proteoglycan of basement membranes, is
also a prominent component of the cartilaginous
primordia in the developing human fetal spine.
Journal of Histochemistry and Cytochemistry:
imaging the spectrum of cell biology, 51(10),
1331-1341.
2002
Melrose, J., Roberts, S., Smith, S., Menage, J.,
Ghosh, P. (2002). Increased Nerve and Blood
Vessel Ingrowth Associated With Proteoglycan
Depletion in an Ovine Anular Lesion Model of
Experimental Disc Degeneration. Spine, 27(12),
1278-1285.
Knox, S., Merry, C., Stringer, S., Melrose, J.,
Whitelock, J. (2002). Not All Perlecans Are
Created Equal. Journal of Biological Chemistry,
277(17), 14657-14665.
Melrose, J., Smith, S., Knox, S., Whitelock, J.
(2002). Perlecan, the multidomain
HS-proteoglycan of basement membranes, is a
prominent pericellular component of ovine
hypertrophic vertebral growth plate and
cartilaginous endplate chondrocytes.
Histochemistry and Cell Biology, 118(4),
269-280.
Melrose, J., Smith, S., Little, C., Kitson, J., Hwa,
S., Ghosh, P. (2002). Spatial and temporal
localization of transforming growth factor-b,
fibroblast growth factor-2, and osteonectin, and
identification of cells expressing a-smooth
muscle actin in the injured annulus fibrosus.
Implications for extracellular matrix repair.
Spine, 27(16), 1756-1764.
Melrose, J., Smith, S., Ghosh, P. (2002).
Synthesis of a Kunitz-Type Serine Proteinase
Inhibitory Protein That Shares Homology with
Bovine Pancreatic Trypsin Inhibitor by Ovine
Intervertebral Disc Cells in Serum-Free alginate
Bead Culture. Journal of Spinal Disorders and
Techniques, 15(2), 164-171.
Melrose, J., Tammi, M., Smith, S. (2002).
Visualisation of hyaluronan and
hyaluronan-binding proteins within ovine
vertebral cartilages using biotinylated aggrecan
G1-link complex and biotinylated hyaluronan
oligosaccharides. Histochemistry and Cell
Biology, 117(4), 327-333. <a
href="http://dx.doi.org/10.1007/s00418-002-039
2-4">[More Information]</a>
2001
Melrose, J., Ghosh, P., Taylor, T. (2001). A
comparative analysis of the differential spatial
and temporal distributions of the large (aggreca.
Journal of Anatomy, 198, 3-15.
Melrose, J., Ghosh, P., Taylor, T. (2001). A
comparative analysis of the differential spatial
and temporal distributions of the large (aggrecan,
versican) and small (decorin, biglycan,
fibromodulin) proteoglycans of the intervertebral
disc. Journal of Anatomy, 198(1), 3-15.
Melrose, J., Ghosh, P., Shen, B. (2001). Affinity
and western blotting reveal homologies between
ovine intervertebral disc serine proteinase.
Proteomics, 1, 1529-1533.
Melrose, J. (2001). Cartilage and smooth muscle
cell proteoglycans detected by affinity blotting
using biotinylated hyaluronan. In Iozzo RV
(Eds.), Proteoglycan Protocols, (pp. 53-66).
United States: Humana Press.
Melrose, J., Ghosh, P., Taylor, T., Smith, S.
(2001). Differential expression of proteoglycan
epitopes and growth characteristics of
intervertebral disc. Cells Tissues Organs, 168(3),
137-146.
Publications for James Melrose
Melrose, J., Knox,, S., Whitelock, J. (2001).
Electrophoretic, biosensor, and bioactivity
analyses of perlecans of different molecular size.
Proteomics, 1, 1534-1541.
Melrose, J., Smith, S., Little, C., Kitson,, J.,
Hwa, S., Ghosh, P. (2001). Repair of annular
disc lesions: Spatial and temporal localisation of
TGF-beta, SPARC (Osteonectin, BM-40) and
FGF-2 are early responses in experimentally
injured ovine discs. 47th Annual Meeting of the
Orthopaedic Research Society, USA:
Orthopaedic Research Society.
2000
Taylor, T., Melrose, J., Burkhardt, D., Ghosh, P.,
Kettler, A., Wilke, H., Claes, L. (2000). Spinal
biomechanics and aging are major determinants
of the proteoglycan metabolism of intervertebral
disc cells. Spine, 25(23), 3014-3020.