Publications for Helen Rizos Publications for Helen Rizos 2016 Welsh, S., Rizos, H., Scolyer, R., Long, G. (2016). Resistance to combination BRAF and MEK inhibition in metastatic melanoma: Where to next? European Journal of Cancer, 62, 76-85. <a href="http://dx.doi.org/10.1016/j.ejca.2016.04.00 5">[More Information]</a> 2015 Johnson, D., Menzies, A., Zimmer, L., Eroglu, Z., Ye, F., Zhao, S., Rizos, H., Sucker, A., Scolyer, R., Gutzmer, R., Kefford, R., Thompson, J., Pupo, G., Long, G., et al (2015). Acquired BRAF inhibitor resistance: A multicenter meta-analysis of the spectrum and frequencies, clinical behaviour, and phenotypic associations of resistance mechanisms. European Journal of Cancer, 51(18), 2792-2799. <a href="http://dx.doi.org/10.1016/j.ejca.2015.08.02 2">[More Information]</a> Gray, E., Rizos, H., Reid, A., Boyd, S., Pereira, M., Lo, J., Tembe, V., Freeman, J., Lee, J., Scolyer, R., Long, G., Carlino, M., et al (2015). Circulating tumor DNA to monitor treatment response and detect acquired resistance in patients with metastatic melanoma. Oncotarget, 6(39), 42008-42018. <a href="http://dx.doi.org/10.18632/oncotarget.578 8">[More Information]</a> Carlino, M., Fung, C., Shahheydari, H., Todd, J., Boyd, S., Irvine, M., Nagrial, A., Scolyer, R., Kefford, R., Long, G., Rizos, H. (2015). Pre-existing MEK1P124 mutations diminish response to BRAF inhibitors in metastatic melanoma patients. Clinical Cancer Research, 21(1), 98-105. <a href="http://dx.doi.org/10.1158/1078-0432.CCR14-0759">[More Information]</a> Tembe, V., Martino-Echarri, E., Marzec, K., Mok, M., Brodie, K., Mills, K., Lei, Y., deFazio, A., Rizos, H., Kettle, E., Henderson, B., et al (2015). The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function. Cellular Signalling, 27(9), 1763-1771. <a href="http://dx.doi.org/10.1016/j.cellsig.2015.05. 011">[More Information]</a> 2014 Rizos, H., Menzies, A., Pupo, G., Carlino, M., Fung, C., Hyman, J., Haydu, L., Mijatov, B., Becker, T., Boyd, S., Howle, J., Saw, R., Thompson, J., Kefford, R., Scolyer, R., Long, G. (2014). BRAF inhibitor resistance mechanisms in metastatic melanoma: spectrum and clinical impact. Clinical Cancer Research, 20(7), 1965-1977. <a href="http://dx.doi.org/10.1158/1078-0432.CCR13-3122">[More Information]</a> Gallagher, S., Mijatov, B., Gunatilake, D., Gowrishankar, K., Tiffen, J., James, W., Jin, L., Pupo, G., Cullinane, C., McArthur, G., Rizos, H., Hersey, P., et al (2014). Control of NF-kB activity in human melanoma by bromodomain and extra-terminal protein inhibitor I-BET151. Pigment Cell & Melanoma Research, 27(6), 1126-1137. <a href="http://dx.doi.org/10.1111/pcmr.12282">[ More Information]</a> Carlino, M., Todd, J., Gowrishankar, K., Mijatov, B., Pupo, G., Fung, C., Snoyman, S., Hersey, P., Long, G., Kefford, R., Rizos, H. (2014). Differential activity of MEK and ERK inhibitors in BRAF inhibitor resistant melanoma. Molecular Oncology, 8(3), 544-554. <a href="http://dx.doi.org/10.1016/j.molonc.2014.0 1.003">[More Information]</a> Long, G., Fung, C., Menzies, A., Pupo, G., Carlino, M., Hyman, J., Shahheydari, H., Tembe, V., Thompson, J., Saw, R., Howle, J., Scolyer, R., Kefford, R., Rizos, H., et al (2014). Increased MAPK reactivation in early resistance to dabrafenib/trametinib combination therapy of BRAF-mutant metastatic melanoma. Nature Communications, 5, 1-9. <a href="http://dx.doi.org/10.1038/ncomms6694">[ More Information]</a> Gopal, V., Rizos, H., Chen, G., Deng, W., Frederick, D., Cooper, Z., Scolyer, R., Pupo, G., Komurov, K., Sehgal, V., Long, G., et al (2014). Inhibition of mTORC1/2 overcomes resistance to MAPK pathway inhibitors mediated by PGC1α and oxidative phosphorylation in melanoma. Cancer Research, 74(23), 7037-7047. Becker, T., Boyd, S., Mijatov, B., Gowrishankar, K., Snoyman, S., Pupo, G., Scolyer, R., Mann, G., Kefford, R., Zhang, X., Rizos, H. (2014). Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor. Oncogene, 33(9), 1158-1166. <a href="http://dx.doi.org/10.1038/onc.2013.45">[ More Information]</a> Croft, A., Tay, K., Boyd, S., Guo, S., Jiang, C., Lai, F., Tseng, H., Jin, L., Rizos, H., Hersey, P., et al (2014). Oncogenic Activation of MEK/ERK Primes Melanoma Cells for Adaptation to Endoplasmic Reticulum Stress. Journal of Investigative Dermatology, 134(2), 488-497. <a href="http://dx.doi.org/10.1038/jid.2013.325">[ More Information]</a> Parmenter, T., Kleinschmidt, M., Kinross, K., Bond, S., Li, J., Kaadige, M., Rao, A., Sheppard, K., Hugo, W., Pupo, G., Long, G., Scolyer, R., Rizos, H., et al (2014). Response of Publications for Helen Rizos BRAF-mutant melanoma to BRAF inhibition is mediated by a network of transcriptional regulators of glycolysis. Cancer Discovery, 4(4), 423-433. <a href="http://dx.doi.org/10.1158/2159-8290.CD-1 3-0440">[More Information]</a> Inhibition Following Acquired Resistance to BRAF and/or MEK Inhibition in Melanoma. Molecular Cancer Therapeutics, 12(7), 1332-1342. <a href="http://dx.doi.org/10.1158/1535-7163.MCT -13-0011">[More Information]</a> Cisterne, A., Baraz, R., Khan, N., Welschinger, R., Basnett, J., Fung, C., Rizos, H., Bradstock, K., Bendall, L. (2014). Silencer of death domains controls cell death through tumour necrosis factor-receptor 1 and caspase-10 in acute lymphoblastic leukemia. PloS One, 9(7), 1-10. <a href="http://dx.doi.org/10.1371/journal.pone.010 3383">[More Information]</a> Long, G., Wilmott, J., Haydu, L., Tembe, V., Sharma, R., Rizos, H., Thompson, J., Howle, J., Scolyer, R., Kefford, R. (2013). Effects of BRAF inhibitors on human melanoma tissue before treatment, early during treatment and on progression. Pigment Cell & Melanoma Research, 26(4), 499-508. <a href="http://dx.doi.org/10.1111/pcmr.12098">[ More Information]</a> Chien, A., Haydu, L., Biechele, T., Kulikauskas, R., Rizos, H., Kefford, R., Scolyer, R., Moon, R., Long, G. (2014). Targeted BRAF Inhibition Impacts Survival in Melanoma Patients with High Levels of Wnt/Beta-Catenin Signaling. PloS One, 9(4), 1-11. Tran, S., Rizos, H. (2013). Human nevi lack distinguishing senescence traits. Aging, 5(2), 98-99. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=23518674">[More Information]</a> Gallagher, S., Mijatov, B., Gunatilake, D., Tiffen, J., Gowrishankar, K., Jin, L., Pupo, G., Cullinane, C., Prinjha, R., Smithers, N., Rizos, H., Hersey, P., et al (2014). The Epigenetic Regulator I-BET151 Induces BIM Dependent Apoptosis and Cell Cycle Arrest OF Human Melanoma Cells. Journal of Investigative Dermatology, 134(11), 2795-2805. <a href="http://dx.doi.org/10.1038/jid.2014.243">[ More Information]</a> Tran, S., Rizos, H. (2013). Monitoring Oncogenic B-RAF-Induced Senescence in Melanocytes. In Lorenzo Galluzzi, Ilio Vitale, Oliver Kepp and Guido Kroemer (Eds.), Methods in Molecular Biology, Cell Senescence: Methods and Protocols, (pp. 313-326). New York: Springer Science+Business Media. Todd, J., Scurr, L., Becker, T., Kefford, R., Rizos, H. (2014). The MAPK pathway functions as a redundant survival signal that reinforces the PI3K cascade in c-Kit mutant melanoma. Oncogene, 33(2), 236-245. <a href="http://dx.doi.org/10.1038/onc.2012.562">[ More Information]</a> Anastas, J., Kulikauskas, R., Tamir, T., Rizos, H., Long, G., von Euw, E., Yang, P., Chen, H., Haydu, L., Toroni, R., et al (2014). WNT5A enhances resistance of melanoma cells to targeted BRAF inhibitors. Journal of Clinical Investigation, 124(7), 2287-2890. <a href="http://dx.doi.org/10.1172/JCI70156">[Mor e Information]</a> 2013 Gowrishankar, K., Carlino, M., Rizos, H. (2013). Acquired Resistance to Targeted MAPK Inhibition in Melanoma. In Guy Huynh Thien Duc (Eds.), Melanoma - From Early Detection to Treatment, (pp. 197-218). Croatia: Intech. Carlino, M., Gowrishankar, K., Saunders, C., Pupo, G., Snoyman, S., Zhang, X., Saw, R., Becker, T., Kefford, R., Long, G., Rizos, H. (2013). Antiproliferative Effects of Continued Mitogen-Activated Protein Kinase Pathway Boyd, S., Mijatov, B., Pupo, G., Tran, S., Gowrishankar, K., Shaw, H., Goding, C., Scolyer, R., Mann, G., Kefford, R., Rizos, H., Becker, T. (2013). Oncogenic B-RAF(V600E) Signaling Induces the T-Box3 Transcriptional Repressor to Repress E-Cadherin and Enhance Melanoma Cell Invasion. Journal of Investigative Dermatology, 133(5), 1269-1277. <a href="http://dx.doi.org/10.1038/jid.2012.421">[ More Information]</a> Fung, C., Pupo, G., Scolyer, R., Kefford, R., Rizos, H. (2013). p16INK4a deficiency promotes DNA hyper-replication and genetic instability in melanocytes. Pigment Cell & Melanoma Research, 26(2), 236-246. <a href="http://dx.doi.org/10.1111/pcmr.12062">[ More Information]</a> Ye, Y., Jin, L., Wilmott, J., Hu, W., Yosufi, B., Thorne, R., Liu, T., Rizos, H., Yan, X., Dong, L., Hersey, P., Scolyer, R., et al (2013). PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma. Nature Communications, 4, 1-15. <a href="http://dx.doi.org/10.1038/ncomms2489">[ More Information]</a> Todd, J., Becker, T., Kefford, R., Rizos, H. (2013). Secondary c-Kit mutations confer Publications for Helen Rizos acquired resistance to RTK inhibitors in c-Kit mutant melanoma cells. Pigment Cell & Melanoma Research, 26(4), 518-526. <a href="http://dx.doi.org/10.1111/pcmr.12107">[ More Information]</a> 2012 Zhou, L., Pupo, G., Gupta, P., Liu, B., Tran, S., Rahme, R., Wang, B., Rua, R., Rizos, H., Carroll, A., Saksena, N., et al (2012). A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration. BMC Genomics, 13(November), 1-17. <a href="http://dx.doi.org/10.1186/1471-2164-13-6 77">[More Information]</a> Tran, S., Haferkamp, S., Scurr, L., Gowrishankar, K., Becker, T., Desilva, C., Thompson, J., Scolyer, R., Kefford, R., Rizos, H. (2012). Absence of Distinguishing Senescence Traits in Human Melanocytic Nevi. Journal of Investigative Dermatology, 132(9), 2226-2234. <a href="http://dx.doi.org/10.1038/jid.2012.126">[ More Information]</a> Gowrishankar, K., Snoyman, S., Pupo, G., Becker, T., Kefford, R., Rizos, H. (2012). Acquired Resistance to BRAF Inhibition Can Confer Cross-Resistance to Combined BRAF/MEK Inhibition. Journal of Investigative Dermatology, 132(7), 1850-1859. <a href="http://dx.doi.org/10.1038/jid.2012.63">[M ore Information]</a> Wilmott, J., Tembe, V., Howle, J., Sharma, R., Thompson, J., Rizos, H., Lo, R., Kefford, R., Scolyer, R., Long, G. (2012). Intratumoral Molecular Heterogeneity in a BRAF-Mutant, BRAF Inhibitor-Resistant Melanoma: A Case Illustrating the Challenges for Personalized Medicine. Molecular Cancer Therapeutics, 11(12), 2704-2708. <a href="http://dx.doi.org/10.1158/1535-7163.MCT -12-0530">[More Information]</a> David, M., Huynh, M., Kelly, E., Rizos, H., Coleman, H., Rogers, G., Zoellner, H. (2012). Membrane and cytoplasmic marker exchange between malignant neoplastic cells and fibroblasts via intermittent contact: increased tumour cell diversity independent of genetic change. Journal of Pathology, 228(4), 495-505. <a href="http://dx.doi.org/10.1002/path.4063">[Mo re Information]</a> Scurr, L., McKenzie, H., Becker, T., Irvine, M., Lai, K., Mann, G., Scolyer, R., Kefford, R., Rizos, H. (2012). Selective Loss of Wild-Type p16(INK4a) Expression in Human Nevi. Journal of Investigative Dermatology, 131(11), 2329-2332. <a href="http://dx.doi.org/10.1038/jid.2011.197">[ More Information]</a> 2011 Medic, S., Rizos, H., Ziman, M. (2011). Differential PAX3 functions in normal skin melanocytes and melanoma cells. Biochemical and Biophysical Research Communications, 411(4), 832-837. <a href="http://dx.doi.org/10.1016/j.bbrc.2011.07.0 53">[More Information]</a> Avery-Kiejda, K., Bowden, N., Croft, A., Scurr, L., Kairupan, C., Ashton, K., Talseth-Palmer, B., Rizos, H., Zhang, X., Scott, R., et al (2011). P53 in human melanoma fails to regulate target genes associated with apoptosis and the cell cycle and may contribute to proliferation. BMC Cancer, 11(203), 1-17. <a href="http://dx.doi.org/10.1186/1471-2407-11-2 03">[More Information]</a> Rizos, H., Scurr, L. (2011). Senescence. In Anja Bosserhoff (Eds.), Melanoma Development: Molecular Biology, Genetics and Clinical Application, (pp. 235-254). Vienna: Springer. 2010 Irvine, M., Boyd, S., Frausto, M., Mijatov, B., Gallagher, S., Fung, C., Becker, T., Kefford, R., Rizos, H. (2010). Amino terminal hydrophobic import signals target the p14(ARF) tumor suppressor to the mitochondria. Cell Cycle, 9(4), 829-839. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=20107316">[More Information]</a> Jiang, C., Lai, F., Tay, K., Croft, A., Rizos, H., Becker, T., Yang, F., Liu, H., Thorne, R., Hersey, P., et al (2010). Apoptosis of Human Melanoma Cells Induced by Inhibition of B-RAFV600E Involves Preferential Splicing of BimS. Cell Death and Disease, 1(9), e69-1-e69-14. <a href="http://dx.doi.org/10.1038/cddis.2010.48">[ More Information]</a> Zhou, L., Diefenbach, E., Crossett, B., Tran, S., Ng, T., Rizos, H., Rua, R., Wang, B., Kapur, A., Gandhi, K., Saksena, N., et al (2010). First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia. Molecular Neurodegeneration, 5(27), 27-1-27-20. <a href="http://dx.doi.org/10.1186/1750-1326-5-27" >[More Information]</a> Scurr, L., Pupo, G., Becker, T., Lai, K., Schrama, Publications for Helen Rizos D., Haferkamp, S., Irvine, M., Scolyer, R., Mann, G., Becker, J., Kefford, R., Rizos, H. (2010). IGFBP7 Is Not Required for B-RAF-Induced Melanocyte Senescence. Cell, 141(4), 717-727. <a href="http://dx.doi.org/10.1016/j.cell.2010.04.02 1">[More Information]</a> Boyd, S., Scurr, L., Fung, C., Haferkamp, S., Kefford, R., Rizos, H. (2010). Oncogenic B-RAF(V600E) Promotes Anchorage-Independent Survival of Human Melanocytes. Journal of Investigative Dermatology, 130(8), 2144-7. <a href="http://dx.doi.org/10.1038/jid.2010.117">[ More Information]</a> McKenzie, H., Fung, C., Becker, T., Irvine, M., Mann, G., Kefford, R., Rizos, H. (2010). Predicting functional significance of cancer-associated p16(INK4a) mutations in CDKN2A. Human Mutation, 31(6), 692-701. <a href="http://dx.doi.org/10.1002/humu.21245">[ More Information]</a> 2009 Haferkamp, S., Scurr, L., Becker, T., Frausto, M., Kefford, R., Rizos, H. (2009). Oncogene-Induced Senescence Does Not Require the p16INK4a or p14ARF Melanoma Tumor Suppressors. Journal of Investigative Dermatology, 129(8), 1983-1991. <a href="http://dx.doi.org/10.1038/jid.2009.5">[Mo re Information]</a> Becker, T., Haferkamp, S., Dijkstra, M., Scurr, L., Frausto, M., Diefenbach, E., Scolyer, R., Reisman, D., Mann, G., Kefford, R., Rizos, H. (2009). The chromatin remodelling factor BRG1 is a novel binding partner of the tumor suppressor p16INK4a. Molecular Cancer, 8(4), 4-1-4-12. <a href="http://dx.doi.org/10.1186/1476-4598-8-4" >[More Information]</a> Haferkamp, S., Tran, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2009). The relative contributions of the p53 and pRb pathways in oncogene-induced melanocyte senescence. Aging, 1(6), 542-556. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=20157537">[More Information]</a> McKenzie, H., Scurr, L., Kefford, R., Rizos, H. (2009). Wild type and melanoma-associated mutant p16(IN4a) proteins do not oligomerize in vivo. Pigment Cell & Melanoma Research, 22(1), 131-133. <a href="http://dx.doi.org/10.1111/j.1755-148X.200 8.00530.x">[More Information]</a> 2008 Scurr, L., Guminski, A., Chiew, Y., Balleine, R., Sharma, R., Lei, Y., Pryor, K., Wain, G., Brand, A., Byth, K., Kennedy, C., Rizos, H., Harnett, P., deFazio, A. (2008). Ankyrin Repeat Domain 1, ANKRD1, a Novel Determinant of Cisplatin Sensitivity Expressed in Ovarian Cancer. Clinical Cancer Research, 14(21), 6924-6932. <a href="http://dx.doi.org/10.1158/1078-0432.CCR07-5189">[More Information]</a> Haferkamp, S., Becker, T., Scurr, L., Kefford, R., Rizos, H. (2008). p16(INK4a)-induced senescence is disabled by melanoma-associated mutations. Aging Cell, 7(5), 733-745. <a href="http://dx.doi.org/10.1111/j.1474-9726.200 8.00422.x">[More Information]</a> Gallagher, S., Thompson, J., Indsto, J., Scurr, L., Lett, M., Gao, B., Dunleavey, R., Mann, G., Kefford, R., Rizos, H. (2008). p16INK4a expression and absence of activated B-RAF are independent predictors of chemosensitivity in melanoma tumors. NeoPlasia: an international journal of oncology research, 10(11), 1231-1239. <a href="http://dx.doi.org/10.1593/neo.08702">[Mo re Information]</a> 2007 Packer, L., Pavey, S., Boyle, G., Stark, M., Ayub, A., Rizos, H., Hayward, N. (2007). Gene expression profiling in melanoma identifies novel downstream effectors of p14ARF. International Journal of Cancer, 121(4), 784-790. <a href="http://dx.doi.org/10.1002/ijc.22725">[Mor e Information]</a> Rizos, H., Scurr, L., Irvine, M., Alling, N., Kefford, R. (2007). p14ARF Regulates E2F-1 Ubiquitination and Degradation via a p53-Dependent Mechanism. Cell Cycle, 6(14), 1741-1747. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=17630509">[More Information]</a> 2006 Rizos, H., McKenzie, H., Ayub, A., Woodruff, S., Becker, T., Scurr, L., Stahl, J., Kefford, R. (2006). Physical and functional interaction of the p14ARF tumor suppressor with ribosomes. Journal of Biological Chemistry, 281(49), 38080-38088. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=17035234">[More Information]</a> Gallagher, S., Kefford, R., Rizos, H. (2006). The ARF tumour suppressor. The International Journal of Biochemistry and Cell Biology, 38(10), 1637-1641. <a href="http://dx.doi.org/10.1016/j.biocel.2006.02. Publications for Helen Rizos 008">[More Information]</a> 2005 Gallagher, S., Kefford, R., Rizos, H. (2005). Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis. Cell Cycle, 4(3), 465-472. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15701968">[More Information]</a> Becker, T., Rizos, H., Dela Pena, A., Leclercq, I., Woodruff, S., Kefford, R., Mann, G. (2005). Impaired inhibition of NF-kappaB activity by melanoma-associated p16INK4a mutations. Biochemical and Biophysical Research Communications, 332(3), 873-879. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15913553">[More Information]</a> Rizos, H., Woodruff, S., Kefford, R. (2005). p14ARF interacts with the SUMO-conjugating enzyme Ubc9 and promotes the Sumoylation of its binding partners. Cell Cycle, 4(4), 597-603. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15876874">[More Information]</a> Becker, T., Ayub, A., Kefford, R., Mann, G., Rizos, H. (2005). The melanoma-associated 24 base pair duplication in p16INK4a is functionally impaired. International Journal of Cancer, 117(4), 569-573. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15945100">[More Information]</a> 2003 Rizos, H., Diefenbach, E., Badhwar, P., Woodruff, S., Becker, T., Kefford, R., Rooney, R. (2003). Association of p14ARF with the p120E4F transciptional represssor enhances cell cycle inhibition. Journal of Biological Chemistry, 278(7), 4981-4989. 2002 Rizos, H., Diefenbach, E., Badhwar, P., Woodruff, S., Becker, T., Rooney, R., Kefford, R. (2002). Association of p14ARF with the p120E4F Transcriptional Repressor Enhances Cell Cycle Inhibition. Journal of Biological Chemistry, 278(7), 4981-4989. 2001 Rizos, H., Puig, S., Badenas,, C., Malvehy, J., Darmanian, A., Jimenez, L., Mila,, M., Kefford, R. (2001). A melanoma-associated germline mutation in exon 1B inactivates p14ARF. Oncogene, 20(39), 5543-5547. Becker, T., Rizos, H., Kefford, R., Mann, G. (2001). Functional Impairment of Melanoma-associated p16 INK4a mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding1. Clinical Cancer Research, 7, 3282-3288. Rizos, H., Darmanian, A., Mann, G., Kefford, R., Holland, E. (2001). Mutations in the INK4a/ARF Melanoma Susceptibility locus functionally impair p14ARF. Journal of Biological Chemistry, 276(44), 41424-41434. 2000 Rizos, H., Darmanian, A., Mann, G., Kefford, R. (2000). Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization. Oncogene, 19(26), 2978-2985.