Publications for Christopher Liddle
Publications for Christopher Liddle
2016
Watts, M., Gupta, V., Liddle, C. (2016).
Antimicrobials in Cirrhotic Patients After Upper
Gastrointestinal Hemorrhage: One Size No
Longer Fits All. Clinical Gastroenterology and
Hepatology, 14(2), 324-325. <a
href="http://dx.doi.org/10.1016/j.cgh.2015.07.04
0">[More Information]</a>
Watts, M., Gupta, V., Liddle, C. (2016).
Antimicrobials in cirrhotic patients following
upper gastrointestinal hemorrhage: one size no
longer fits all. Clinical Gastroenterology and
Hepatology, 14(2), 324-325. <a
href="http://dx.doi.org/10.1016/j.cgh.2015.07.04
0">[More Information]</a>
Zhou, G., Wilson, G., Hebbard, L., Duan, W.,
Liddle, C., George, J., Qiao, L. (2016).
Aptamers: A promising chemical antibody for
cancer therapy. Oncotarget, 7(12), 13446-13463.
<a
href="http://dx.doi.org/10.18632/oncotarget.717
8">[More Information]</a>
Booth, D., Ding, N., Parnell, G., Shahijanian, F.,
Coulter, S., Schibeci, S., Atkins, A., Stewart, G.,
Evans, R., Downes, M., Liddle, C. (2016).
Cistromic and genetic evidence that the vitamin
D receptor mediates susceptibility to
latitude-dependent autoimmune diseases. Genes
and Immunity, 17(4), 213-219. <a
href="http://dx.doi.org/10.1038/gene.2016.12">[
More Information]</a>
Yoshihara, E., Wei, Z., Lin, C., Fang, S.,
Ahmadian, M., Kida, Y., Tseng, T., Dai, Y., Yu,
R., Liddle, C., et al (2016). ERRy Is Required for
the Metabolic Maturation of Therapeutically
Functional Glucose-Responsive β Cells. Cell
Metabolism, 23(4), 622-634. <a
href="http://dx.doi.org/10.1016/j.cmet.2016.03.0
05">[More Information]</a>
Eslam, M., Hashem, A., Romero-Gomez, M.,
Berg, T., Dore, G., Mangia, A., Chan, H., Irving,
W., Sheridan, D., Abate, M., Weltman, M.,
Ahlenstiel, G., Liddle, C., Douglas, M., Booth,
D., George, J., et al (2016). FibroGENE: A
gene-based model for staging liver fibrosis.
Journal of Hepatology, 64(2), 390-398. <a
href="http://dx.doi.org/10.1016/j.jhep.2015.11.0
08">[More Information]</a>
2015
Reilly, S., Ahmadian, M., Zamarron, B., Chang,
L., Uhm, M., Poirier, B., Peng, X., Krause, D.,
Korytnaya, E., Neidert, A., Liddle, C., et al
(2015). A subcutaneous adipose tissue-liver
signalling axis controls hepatic gluconeogenesis.
Nature Communications, 6, 1-12. <a
href="http://dx.doi.org/10.1038/ncomms7047">[
More Information]</a>
Ding, N., Hah, N., Yu, R., Sherman, M., Benner,
C., Leblanc, M., He, M., Liddle, C., Downes, M.,
Evans, R. (2015). BRD4 is a novel therapeutic
target for liver fibrosis. Proceedings of the
National Academy of Sciences of the United
States of America (PNAS), 112(51),
15713-15718. <a
href="http://dx.doi.org/10.1073/pnas.152216311
2">[More Information]</a>
Arensman, M., Nguyen, P., Kershaw, K., Lay,
A., Ostertag-Hill, C., Sherman, M., Downes, M.,
Liddle, C., Evans, R., Dawson, D. (2015).
Calcipotriol Targets LRP6 to Inhibit Wnt
Signaling in Pancreatic Cancer. Molecular
Cancer Research.
Hallwirth, C., Garg, G., Peters, T., Kramer, B.,
Malani, N., Hyman, J., Ruan, X., Ginn, S.,
Hetherington, N., Veeravalli, L., Liddle, C.,
Alexander, I., et al (2015). Coherence analysis
discriminates between retroviral integration
patterns in CD34(+) cells transduced under
differing clinical trial conditions. Molecular
Therapy - Methods & Clinical Development, 2,
1-10. <a
href="http://dx.doi.org/10.1038/mtm.2015.15">[
More Information]</a>
Pei, L., Mu, Y., Leblanc, M., Alaynick, W.,
Barish, G., Pankratz, M., Tseng, T., Kaufman, S.,
Liddle, C., Yu, R., et al (2015). Dependence of
Hippocampal Function on
ERR-Gamma-Regulated Mitochondrial
Metabolism. Cell Metabolism, 21(4), 628-636.
<a
href="http://dx.doi.org/10.1016/j.cmet.2015.03.0
04">[More Information]</a>
Bapat, S., Suh, J., Fang, S., Liu, S., Zhang, Y.,
Cheng, A., Zhou, C., Liang, Y., Leblanc, M.,
Liddle, C., et al (2015). Depletion of fat-resident
Treg cells prevents age-associated insulin
resistance. Nature, 528(7580), 137-141. <a
href="http://dx.doi.org/10.1038/nature16151">[
More Information]</a>
Kida, Y., Kawamura, T., Wei, Z., Sogo, T.,
Jacinto, S., Shigeno, A., Kushige, H., Yoshihara,
E., Liddle, C., Ecker, J., et al (2015). ERRs
Mediate a Metabolic Switch Required for
Somatic Cell Reprogramming to Pluripotency.
Cell Stem Cell, 16(5), 547-555. <a
href="http://dx.doi.org/10.1016/j.stem.2015.03.0
01">[More Information]</a>
Scott, C., Cha, K., Rao, R., Liddle, C., George,
J., Gunton, J. (2015). Hepatocyte- Specific
Deletion of ARNT (Aryl Hydrocarbon Receptor
Nuclear Translocator) Results in Altered Fibrotic
Gene Expression in the Thioacetamide Model of
Liver Injury. PloS One, 10(3), 1-11. <a
Publications for Christopher Liddle
href="http://dx.doi.org/10.1371/journal.pone.012
1650">[More Information]</a>
Wall, C., Whyte, J., Suh, J., Fan, W., Collins, B.,
Liddle, C., Yu, R., Atkins, A., Naviaux, J., Li,
K., et al (2015). High-fat diet and FGF21
cooperatively promote aerobic thermogenesis in
mtDNA mutator mice. Proceedings of the
National Academy of Sciences of the United
States of America (PNAS), 112(28), 8714-8719.
<a
href="http://dx.doi.org/10.1073/pnas.150993011
2">[More Information]</a>
Eslam, M., Hashem, A., Leung, R.,
Romero-Gomez, M., Berg, T., Dore, G., Chan,
H., Irving, W., Sheridan, D., Abate, M.,
Weltman, M., Douglas, M., Liddle, C., Booth,
D., George, J., Ahlenstiel, G., et al (2015).
Interferon-λ rs12979860 genotype and liver
fibrosis in viral and non-viral chronic liver
disease. Nature Communications, 6, 1-10. <a
href="http://dx.doi.org/10.1038/ncomms7422">[
More Information]</a>
Fang, S., Suh, J., Reilly, S., Yu, E., Osborn, O.,
Lackey, D., Yoshihara, E., Perino, A., Jacinto,
S., Lukasheva, Y., Coulter, S., Liddle, C., et al
(2015). Intestinal FXR agonism promotes
adipose tissue browning and reduces obesity and
insulin resistance. Nature Medicine, 21(2),
159-165. <a
href="http://dx.doi.org/10.1038/nm.3760">[Mor
e Information]</a>
2014
Zhuang, L., Hulin, J., Gromova, A., Nguyen, T.,
Yu, R., Liddle, C., Downes, M., Evans, R.,
Makarenkova, H., Meech, R. (2014). Barx2 and
Pax7 Have Antagonistic Functions in Regulation
of Wnt Signaling and Satellite Cell
Differentiation. Stem Cells, 32(6), 1661-1673. <a
href="http://dx.doi.org/10.1002/stem.1674">[Mo
re Information]</a>
Khushi, M., Liddle, C., Clarke, C., Graham, J.
(2014). Binding Sites Analyser (BiSA): Software
for Genomic Binding Sites Archiving and
Overlap Analysis. PloS One, 9(2), 1-12. <a
href="http://dx.doi.org/10.1371/journal.pone.008
7301">[More Information]</a>
Suh, J., Jonker, J., Ahmadian, M., Goetz, R.,
Lackey, D., Osborn, O., Huang, Z., Liu, W.,
Yoshihara, E., van Dijk, T., Liddle, C., et al
(2014). Endocrinization of FGF1 produces a
neomorphic and potent insulin sensitizer. Nature,
513(7518), 436-439. <a
href="http://dx.doi.org/10.1038/nature13540">[
More Information]</a>
O'Connor, K., Parnell, G., Patrick, E., Ahlenstiel,
G., Suppiah, V., van der Poorten, D., Read, S.,
Leung, R., Douglas, M., Yang, J., Stewart, G.,
Liddle, C., George, J., Booth, D. (2014). Hepatic
metallothionein expression in chronic hepatitis C
virus infection is IFNL3 genotype-dependent.
Genes and Immunity, 15(2), 88-94. <a
href="http://dx.doi.org/10.1038/gene.2013.66">[
More Information]</a>
O'Connor, K., Ahlenstiel, G., Suppiah, V.,
Schibeci, S., Ong, A., Leung, R., van der
Poorten, D., Douglas, M., Weltman, M., Stewart,
G., Liddle, C., George, J., Booth, D. (2014).
IFNL3 mediates interaction between innate
immune cells: Implications for hepatitis C virus
pathogenesis. Innate Immunity, 20(6), 598-605.
<a
href="http://dx.doi.org/10.1177/1753425913503
385">[More Information]</a>
Vanwijngaerden, Y., Langouche, L., Derde, S.,
Liddle, C., Coulter, S., van den Berghe, G.,
Mesotten, D. (2014). Impact of Parenteral
Nutrition Versus Fasting on Hepatic Bile Acid
Production and Transport in a Rabbit Model of
Prolonged Critical Illness. Shock, 41(1), 48-54.
<a
href="http://dx.doi.org/10.1097/SHK.000000000
0000046">[More Information]</a>
Lu, B., Bridges, D., Yang, Y., Fisher, K., Cheng,
A., Chang, L., Meng, Z., Lin, J., Downes, M.,
Yu, R., Liddle, C., et al (2014). Metabolic
Crosstalk: molecular links between glycogen and
lipid metabolism in obesity. Diabetes, 63(9),
2935-2948. <a
href="http://dx.doi.org/10.2337/db13-1531">[M
ore Information]</a>
Parnell, G., Gatt, P., McKay, F., Schibeci, S.,
Krupa, M., Powell, J., Visscher, P., Montgomery,
G., Lechner-Scott, J., Broadley, S., Liddle, C.,
Vucic, S., Stewart, G., Booth, D., et al (2014).
Ribosomal protein S6 mRNA is a biomarker
upregulated in multiple sclerosis, downregulated
by interferon treatment, and affected by season.
Multiple Sclerosis Journal, 20(6), 675-685. <a
href="http://dx.doi.org/10.1177/1352458513507
819">[More Information]</a>
Shahijanian, F., Parnell, G., McKay, F., Gatt, P.,
Shojaei, M., O'Connor, K., Schibeci, S.,
Brilot-Turville, F., Liddle, C., Batten, M.,
Stewart, G., Booth, D. (2014). The CYP27B1
variant associated with increased risk of
autoimmune disease is underexpressed in
tolerising dendritic cells. Human Molecular
Genetics, 23(6), 1425-1434. <a
href="http://dx.doi.org/10.1093/hmg/ddt529">[
More Information]</a>
Sherman, M., Yu, R., Engle, D., Ding, N.,
Atkins, A., Tiriac, H., Collisson, E., Connor, F.,
Van Dyke, T., Kozlov, S., Lau, S., Gunton, J.,
Liddle, C., et al (2014). Vitamin D
Receptor-Mediated Stromal Reprogramming
Publications for Christopher Liddle
Suppresses Pancreatitis and Enhances Pancreatic
Cancer Therapy. Cell, 159(1), 80-93. <a
href="http://dx.doi.org/10.1016/j.cell.2014.08.00
7">[More Information]</a>
Vanwijngaerden, Y., Langouche, L., Brunner, R.,
Debaveye, Y., Gielen, M., Casaer, M., Liddle,
C., Coulter, S., Wouters, P., Wilmer, A., et al
(2014). Withholding Parenteral Nutrition During
Critical Illness Increases Plasma Bilirubin but
Lowers the Incidence of Biliary Sludge.
Hepatology, 60(1), 202-210. <a
href="http://dx.doi.org/10.1002/hep.26928">[Mo
re Information]</a>
2013
Ding, N., Yu, R., Subramaniam, N., Sherman,
M., Wilson, C., Rao, R., Leblanc, M., Coulter,
S., He, M., Scott, C., Liddle, C., et al (2013). A
Vitamin D Receptor/SMAD Genomic Circuit
Gates Hepatic Fibrotic Response. Cell, 153(3),
601-613. <a
href="http://dx.doi.org/10.1016/j.cell.2013.03.02
8">[More Information]</a>
Reilly, S., Chiang, S., Decker, S., Chang, L.,
Uhm, M., Larsen, M., Rubin, J., Mowers, J.,
White, N., Hochberg, I., Liddle, C., et al (2013).
An inhibitor of the protein kinases TBK1 and
IKK-epsilon improves obesity-related metabolic
dysfunctions in mice. Nature Medicine, 19(3),
313-321. <a
href="http://dx.doi.org/10.1038/nm.3082">[Mor
e Information]</a>
Kacevska, M., Mahns, A., Sharma, R., Clarke,
S., Robertson, G., Liddle, C. (2013).
Extra-Hepatic Cancer Represses Hepatic Drug
Metabolism Via Interleukin (IL)-6 Signalling.
Pharmaceutical Research, 30(9), 2270-2278. <a
href="http://dx.doi.org/10.1007/s11095-013-104
2-3">[More Information]</a>
Ding, N., Liddle, C., Evans, R., Downes, M.
(2013). Hepatic actions of vitamin D receptor
ligands: a sunshine option for chronic liver
disease? Expert Review of Clinical
Pharmacology, 6(6), 597-599. <a
href="http://dx.doi.org/10.1586/17512433.2013.
841078">[More Information]</a>
van der Poorten, D., Samer, C.,
Ramezani-Moghadam, M., Coulter, S.,
Kacevska, M., Schrijnders, D., Wu, L., McLeod,
D., Bugianesi, E., Komuta, M., Liddle, C.,
Hebbard, L., George, J., et al (2013). Hepatic Fat
Loss in Advanced Nonalcoholic
Karunasiri, M., Liddle, C., Schwalie, P., Hubner,
N., Evans, R. (2013). Insights into Negative
Regulation by the Glucocorticoid Receptor from
Genome-wide Profiling of Inflammatory
Cistromes. Molecular Cell, 49(1), 158-171. <a
href="http://dx.doi.org/10.1016/j.molcel.2012.10
.013">[More Information]</a>
Ahmadian, M., Suh, J., Hah, N., Liddle, C.,
Atkins, A., Downes, M., Evans, R. (2013).
PPARγ signaling and metabolism: the good, the
bad and the future. Nature Medicine, 19(5),
557-566. <a
href="http://dx.doi.org/10.1038/nm.3159">[Mor
e Information]</a>
O'Connor, K., Liddle, C. (2013). Prospective
data collection of off-label use of rituximab in
Australian public hospitals. Internal Medicine
Journal, 43(8), 863-870. <a
href="http://dx.doi.org/10.1111/imj.12206">[Mo
re Information]</a>
Liddle, C., Goodwin, B. (2013). Xenobiotic
related induction of gene expression of
cytochrome CYP3A4. Patent No. 2154250,
2333016, 7638614, DK/EP 2154250, EP
2154250. Canada, Denmark, Germany, Ireland,
Netherlands, Sweden, Switzerland, United
Kingdom.
2012
Jonker, J., Liddle, C., Downes, M. (2012). FXR
and PXR: Potential therapeutic targets in
cholestasis. Journal of Steroid Biochemistry and
Molecular Biology, 130(3-5), 147-158. <a
href="http://dx.doi.org/10.1016/j.jsbmb.2011.06.
012">[More Information]</a>
Subramaniam, N., Sherman, M., Rao, R.,
Wilson, C., Coulter, S., Atkins, A., Evans, R.,
Liddle, C., Downes, M. (2012).
Metformin-mediated Bambi expression in
hepatic stellate cells induces prosurvival
Wnt/β-catenin signaling. Cancer Prevention
Research, 5(4), 553-561. <a
href="http://dx.doi.org/10.1158/1940-6207.CAP
R-12-0053">[More Information]</a>
Cho, H., Zhao, X., Hatori, M., Yu, R., Barish, G.,
Lam, M., Chong, L., DiTacchio, L., Atkins, A.,
Glass, C., Liddle, C., et al (2012). Regulation of
circadian behaviour and metabolism by
REV-ERB-a and REV-ERB-B. Nature,
485(7396), 123-127. <a
href="http://dx.doi.org/10.1038/nature11048">[
More Information]</a>
Steatohepatitis: Are Alterations in Serum
Adiponectin the Cause? Hepatology, 57(6),
2180-2188. <a
href="http://dx.doi.org/10.1002/hep.26072">[Mo
re Information]</a>
Liddle, C., Goodwin, B., Robertson, G. (2012).
P450 Gene Regulation. Patent No.
2007249083, 2426959, 8088968. Canada.
Uhlenhaut, N., Barish, G., Yu, R., Downes, M.,
Vanwijngaerden, Y., Wauters, J., Langouche, L.,
2011
Publications for Christopher Liddle
Perre, S., Liddle, C., Coulter, S., Vanderborght,
S., Roskams, T., Wilmer, A., et al (2011).
Critical illness evokes elevated circulating bile
acids related to altered hepatic transporter and
nuclear receptor expression. Hepatology, 54(5),
1741-1752. <a
href="http://dx.doi.org/10.1002/hep.24582">[Mo
re Information]</a>
Kacevska, M., Downes, M., Sharma, R., Evans,
R., Clarke, S., Liddle, C., Robertson, G. (2011).
Extrahepatic Cancer Suppresses Nuclear
Receptor-Regulated Drug Metabolism. Clinical
Cancer Research, 17(10), 3170-3180. <a
href="http://dx.doi.org/10.1158/1078-0432.CCR10-3289">[More Information]</a>
Wu, A., Coulter, S., Liddle, C., Wong, A.,
Eastham-Anderson, J., French, D., Peterson, A.,
Sonoda, J. (2011). FGF19 Regulates Cell
Proliferation, Glucose and Bile Acid Metabolism
via FGFR4-Dependent and Independent
Pathways. PloS One, 6(3), 1-11. <a
href="http://dx.doi.org/10.1371/journal.pone.001
7868">[More Information]</a>
Chmiel, K., Suan, D., Liddle, C., Nankivell
(Nankievell), B., Ibrahim, R., Bautista, C.,
Thompson, J., Fulcher, D., Kefford, R. (2011).
Resolution of Severe Ipilimumab-Induced
Hepatitis After Antithymocyte Globulin
Therapy. Journal of Clinical Oncology, 29(9),
237-240. <a
href="http://dx.doi.org/10.1200/JCO.2010.32.22
06">[More Information]</a>
Suan, D., O'Connor, K., Booth, D., Liddle, C.,
Stewart, G. (2011). Voriconazole toxicity related
to polymorphisms in CYP2C19. Internal
Medicine Journal, 41(4), 364-365. <a
href="http://dx.doi.org/10.1111/j.1445-5994.201
1.02454.x">[More Information]</a>
2010
Liddle, C., Stedman, C., Downes, M. (2010).
Signaling Pathways in Liver Diseases: PXR and
CAR. In J.F. Dufour and P.A. Clavien (Eds.),
Signaling Pathways in Liver Diseases, (pp.
333-344). United States of America: Springer.
Goodwin, B., Liddle, C. (2010). Xenobiotic
Related Induction of Gene Expression. Patent
No. 1082437, 4446603, 69941813.5,
99923306.7. Germany, Spain.
2009
Hilmer, S., Seale, J., Le Couteur, D., Crampton,
R., Liddle, C. (2009). Do medical courses
adequately prepare interns for safe and effective
prescribing in New South Wales public
hospitals? Internal Medicine Journal, 39(7),
428-434. <a
href="http://dx.doi.org/10.1111/j.1445-5994.200
9.01942.x">[More Information]</a>
Jonker, J., Stedman, C., Liddle, C., Downes, M.
(2009). Hepatobiliary ABC transporters:
physiology, regulation and implications for
disease. Frontiers in Bioscience, 14, 4904-4920.
<a href="http://dx.doi.org/10.2741/3576">[More
Information]</a>
Liddle, C., Goodwin, B., Robertson, G. (2009).
Transgenic Animals For Analysing CYP3A4
Cytochrome P450 Gene Regulation. Patent No.
7531712.
2008
Sharma, R., Kacevska, M., London, R., Clarke,
S., Liddle, C., Robertson, G. (2008).
Downregulation of drug transport and
metabolism in mice bearing extra-hepatic
malignancies. British Journal of Cancer, 98(1),
91-97. <a
href="http://dx.doi.org/10.1038/sj.bjc.6604101">
[More Information]</a>
Robertson, G., Liddle, C., Clarke, S. (2008).
Inflammation and Altered Drug Clearance in
Cancer: Transcriptional Repression of a Human
CYP3A4 Transgene in Tumor-bearing Mice.
Pharmacology and Therapeutics, 83(6),
894-897. <a
href="http://dx.doi.org/10.1038/clpt.2008.55">[
More Information]</a>
Kacevska, M., Robertson, G., Clarke, S., Liddle,
C. (2008). Inflammation and CYP3A4-mediated
drug metabolism in advanced cancer: impact and
implications for chemotherapeutic drug dosing.
Expert Opinion on Drug Metabolism and
Toxicology, 4(2), 137-149. <a
href="http://dx.doi.org/10.1517/17425255.4.2.13
7">[More Information]</a>
Downes, M., Liddle, C. (2008). Look who's
talking: nuclear receptors in the liver and
gastrointestinal tract. Cell Metabolism, 7(3),
195-199. <a
href="http://dx.doi.org/10.1016/j.cmet.2008.02.0
06">[More Information]</a>
Liddle, C. (2008). Mass in the Liver. In N
Talley, I Segal, M Weltman (Eds.),
Gastroenterology and Hepatology: a clinical
handbook, (pp. 461-467). Australia: Elsevier.
George, J., Liddle, C. (2008). Nonalcoholic fatty
liver disease: Pathogenesis and potential for
nuclear receptors as therapeutic targets.
Molecular Pharmaceutics, 5(1), 49-59. <a
href="http://dx.doi.org/10.1021/mp700110z">[M
ore Information]</a>
Morgan, E., Goralski, K., Piquette-Miller, M.,
Renton, K., Robertson, G., Chaluvadi, M.,
Charles, K., Clarke, S., Kacevska, M., Liddle, C.,
et al (2008). Regulation of drug-metabolizing
enzymes and transporters in infection,
inflammation, and cancer. Drug Metabolism and
Publications for Christopher Liddle
Disposition, 36(2), 205-216. <a
href="http://dx.doi.org/10.1124/dmd.107.018747
">[More Information]</a>
Sharma, R., Zucknick, M., London, R.,
Kacevska, M., Liddle, C., Clarke, S. (2008).
Systemic inflammatory response predicts
prognosis in patients with advanced-stage
colorectal cancer. Clinical Colorectal Cancer,
7(5), 331-337. <a
href="http://dx.doi.org/10.3816/CCC.2008.n.044
">[More Information]</a>
Sharma, R., Hoskins, J., Rivory, L., Zucknick,
M., London, R., Liddle, C., Clarke, S. (2008).
Thymidylate synthase and
methylenetetrahydrofolate reductase gene
polymorphisms and toxicity to capecitabine in
advanced colorectal cancer patients. Clinical
Cancer Research, 14(3), 817-825. <a
href="http://dx.doi.org/10.1158/1078-0432.CCR07-0425">[More Information]</a>
Klumpen, H., Liddle, C., Gurney, H. (2008).
Transporter pumps and imatinib: A cause of
pharmacokinetic resistance? Cancer Biology &
Therapy, 7(3), 416-418. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18334863">[More Information]</a>
2007
Sharma, R., Koller, L., Barclay, P., Liddle, C.
(2007). Evaluation of the off-label usage of
rituximab in a large teaching hospital in New
South Wales. Internal Medicine Journal, 37(8),
569-571. <a
href="http://dx.doi.org/10.1111/j.1445-5994.200
7.01406.x">[More Information]</a>
Liddle, C., Stedman, C. (2007). Hepatic
Metabolism of Drugs. In Juan Rodes,
Jean-Pierre Benhamou, Andres Blei, Juerg
Reichen, and Mario Rizzetto (Eds.), The
Textbook of Hepatology: From Basic Science to
Clinical Practice, (pp. 241-249). USA:
Blackwell Publishers.
2006
Stedman, C., Liddle, C., Coulter, S., Sonoda, J.,
Alvarez, J., Evans, R., Downes, M. (2006).
Benefit of farnesoid X receptor inhibition in
obstructive cholestasis. Proceedings of the
National Academy of Sciences of the United
States of America (PNAS), 103(30),
11323-11328. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16844773">[More Information]</a>
Liddle, C., Goodwin, B. (2006). Cytochrome
P450 Transcriptional Enhancer Nucleic Acid
Molecule. Patent No. 6984489.
Charles (nee Slaviero), K., Rivory, L., Brown, S.,
Liddle, C., Clarke, S., Robertson, G. (2006).
Transcriptional repression of hepatic cytochrome
P450 3A4 gene in the presence of cancer.
Clinical Cancer Research, 12(24), 7492-7497.
<a
href="http://dx.doi.org/10.1158/1078-0432.CCR06-0023">[More Information]</a>
Liddle, C., Goodwin, B. (2006). Patent No.
6984489.
2005
Stedman, C., Liddle, C., Coulter, S., Sonoda, J.,
Alvarez, J., Moore, D., Evans, R., Downes, M.
(2005). Nuclear receptors constitutive androstane
receptor and pregnane X receptor ameliorate
cholestatic liver injury. Proceedings of the
National Academy of Sciences of the United
States of America (PNAS), 102(6), 2063-2068.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15684063">[More Information]</a>
Sonoda, J., Chong, L., Downes, M., Barish, G.,
Coulter, S., Liddle, C., Lee, C., Evans, R. (2005).
Pregnane X receptor prevents hepatorenal
toxicity from cholesterol metabolites.
Proceedings of the National Academy of
Sciences of the United States of America (PNAS),
102(6), 2198-203. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15671183">[More Information]</a>
Esteban, L., Fong, C., Amr, D., Cock, T.,
Allison, S., Flanagan, J., Liddle, C., Eisman, J.,
Gardiner, E. (2005). Promoter-, cell-, and
ligand-specific transactivation responses of the
VDRB1 isoform. Biochemical and Biophysical
Research Communications, 334(1), 9-15. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15992766">[More Information]</a>
Liddle, C., Rangan, G., Coombes, J., Mreich, E.
(2005). Rapamycin worsens renal function and
intratubular cast formation in protein overload
nephropathy. Kidney International. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16316336">[More Information]</a>
2004
Wong, M., Balleine, R., Collins, M., Liddle, C.,
Clarke, C., Gurney, H. (2004). Cyp3A5
Genotype And Midazolam Clearance In
Australian Patients Receiving Chemotherapy.
Pharmacology and Therapeutics, 75(6),
529-538. <a
href="http://dx.doi.org/10.1016/j.clpt.2004.02.00
5">[More Information]</a>
Publications for Christopher Liddle
Coverdale, S., Khan, M., Byth Wilson, K., Lin,
R., Weltman, M., George, J., Samarasinghe, D.,
Liddle, C., Farrell, G., Kench, J., Crewe, E.
(2004). Effects Of Interferon Treatment
Response On Liver Complications Of Chronic
Hepatitis C: 9-Year Follow-Up Study. American
Journal of Gastroenterology, 99(4), 636-644.
Stedman, C., Robertson, G., Coulter, S., Liddle,
C. (2004). Feed-Forward Regulation Of Bile
Acid Detoxification By Cyp3A4: Studies In
Humanized Transgenic Mice. Journal of
Biological Chemistry, 279(12), 11336-11346.
Sud, A., Hui, J., Farrell, G., Bandara, P., Kench,
J., Fung, C., Lin, R., Samarasinghe, D., Liddle,
C., McCaughan, G., George, J. (2004). Improved
Prediction Of Fibrosis In Chronic Hepatitis C
Using Measures Of Insulin Resistance In A
Probability Index. Hepatology, 39(5),
1239-1247. <a
href="http://dx.doi.org/10.1002/hep.20207">[Mo
re Information]</a>
2003
Coverdale, S., Samarasinghe, D., Lin, R., Kench,
J., Byth Wilson, K., Khan, M., Crewe, E., Liddle,
C., George, J., Farrell, G. (2003). Changes in
Antipyrine Clearance and Platelet Count,
but Not Conventional Liver Tests, Correlate
With
Fibrotic Change in Chronic Hepatitis C: Value
for
Predicting Fibrotic Progression. American
Journal of Gastroenterology, 98(6), 1384-1390.
Kumar, D., Wallington-Beddoe, C., George, J.,
Lin, R., Samarasinghe, D., Liddle, C., Farrell, G.
(2003). Effectiveness of interferon
alfa-2b/ribavirin combination therapy for chronic
hapatitis c in a clinic setting. Medical Journal of
Australia, 178(6), 267-271.
Mesotten, D., Van den Berghe, G., Liddle, C.,
Coulter, S., McDougall, F., Baxter, R., Delhanty,
P. (2003). Growth hormone modulation of the rat
hepatic bile transporter system in
endotoxin-induced cholestasis. Endocrinology,
144(9), 4008-4017.
Liddle, C., Robertson, G. (2003). Predicting
inductive drug-drug interactions.
Pharmacogenomics, 4(2), 141-152.
Robertson, G., Field, J., Goodwin, B., Bierach,
S., Tran, M., Lehnert, A., Liddle, C. (2003).
Transgenic mouse models of human CYP3A4
gene regulation. Molecular Pharmacology,
64(1), 42-50.
2002
Hui, J., George, J., Liddle, C., Lin, R.,
Samarasinghe, D., Crewe, E., Farrell, G. (2002).
Changes in Serum Albumin During Treatment of
Chronic Hepatitis B With Lamivudine: Effects of
Response and Emergence of Drug Resistance.
American Journal of Gastroenterology, 97(4),
1003-1009.
Farrell, G., Liddle, C. (2002). Drugs and the liver
updated, 2002. Seminars in Liver Disease, 22(2),
109-113.
Hui, J., Kench, J., Farrell, G., Lin, R.,
Samarasinghe, D., Liddle, C., Byth, K., George,
J. (2002). Genotype-specific mechanisms for
hepatic steatosis in chronic hepatitis C infection.
Journal of Gastroenterology and Hepatology,
17(8), 873-881.
Hui, J., Farrell, G., Lin, R., Samarasinghe, D.,
Liddle, C., George, J., Kench, J., Byth, K.
(2002). Hepatic Steatosis in Chronic Hepatitis C
Infection. Journal of Gastroenterology and
Hepatology, 17(8), 873-881.
Chitturi, S., Weltman, M., Farrell, G.,
McDonald, D., Liddle, C., Samarasinghe, D.,
Lin, R., Abeygunasekera, S., George, J. (2002).
HFE Mutations, Hepatic Iron, and Fibrosis:
Ethnic-Specification Association of NASH with
C282Y but not with Fibrotic Severity.
Hepatology, 36(1), 142-149.
Chitturi, S., Abeygunasekera, S., Farrell, G.,
Holmes-Walker, J., Hui, J., Fung, C., Karim, R.,
Lin, R., Samarasinghe, D., Liddle, C., Weltman,
M., George, J. (2002). NASH and Insulin
Resistance: Insulin Hypersecretion and Specific
Association with the Insulin Resistance
Syndrome. Hepatology, 35(2), 373-379.
Liddle, C., Goodwin, B. (2002). Regulation of
hepatic drug metabolism: role of the nuclear
receptors PXR and CAR. Seminars in Liver
Disease, 22(2), 115-122.
Chitturi, S., Farrell, G., Frost, L., Kriketos, A.,
Lin, R., Liddle, C., Samarasinghe, D., George, J.
(2002). Serum Leptin in NASH Correlates with
Hepatic Steatosis but not Fibrosis: A
Manifestation of Lipotoxicity? Hepatology,
36(2), 403-409.
Spurdle, A., Goodwin, B., Hodgson, E., Liddle,
C., Hopper, J., Chen, X., Purdie, D., McCredie,
M., Giles, G., Chenevix-Trench, G. (2002). The
CYP3A4*1B polymorphism has no functional
significance and is not associated with risk of
breast or ovarian cancer. Pharmacogenetics and
Genomics, 12(5), 355-366.
Goodwin, B., Hodgson, E., D'Costa, D.,
Robertson, G., Liddle, C. (2002). Transcriptional
regulation of the human CYP3A4 gene by the
constitutive androstane receptor. Molecular
Pharmacology, 62, 359-365.
2001
Publications for Christopher Liddle
Amr, D., Liddle, C. (2001). A novel
polymorphism affects transcription of the
CYP3A4 gene. Journal of Gastroenterology and
Hepatology, 16.
Stedman, C., Robertson, G., Liddle, C., Field, J.
(2001). Hepatoprotective response to cholestasis:
bile duct ligation activates transcription of a
human activates transcription of a human
CYP3A4/LACZ transgene in mice. Journal of
Gastroenterology and Hepatology, 16.
Farrell, G., Liddle, C., Samarasinghe, D.,
Chitturi, S., Frost, L. (2001). Serum leptin is a
predictor of severity of hepatic steatosis in
NASH but does not correlate with fibrotic
severity. Journal of Gastroenterology and
Hepatology, 16.
Farrell, G., Liddle, C., Samarasinghe, D., Lin, R.,
George, J., Chitturi, S., Frost, L. (2001). Serum
Leptin: An independent predictor of hepatic
steatosis but not fibrotic severity in nonalcoholic
steatohepatitis. Hepatology, 34, 752-752.