Publications for David Little
Publications for David Little
18">[More Information]</a>
2016
Ibrahim, T., Mahmoud, S., Riaz, M., Hegazy, A.,
Little, D. (2015). Hip decompression of unstable
slipped capital femoral epiphysis: a systematic
review and meta-analysis. Journal of Children's
Orthopaedics, 9(2), 113-120. <a
href="http://dx.doi.org/10.1007/s11832-015-064
8-x">[More Information]</a>
Padhye, B., Dalla-Pozza, L., Little, D., Munns,
C. (2016). Incidence and outcome of
osteonecrosis in children and adolescents after
intensive therapy for acute lymphoblastic
leukemia (ALL). Cancer Medicine, 5(5),
960-967. <a
href="http://dx.doi.org/10.1002/cam4.645">[Mor
e Information]</a>
Yu, N., Fathi, A., Murphy, C., Mikulec, K.,
Peacock, L., Cantrill, L., Dehghani, F., Little, D.,
Schindeler, A. (2016). Local co-delivery of
rhBMP-2 and cathepsin K inhibitor L006235 in
poly(D,L-lactide-co-glycolide) nanospheres [In
Press]. Journal of Biomedical Materials
Research. Part B: Applied Biomaterials. <a
href="http://dx.doi.org/10.1002/jbm.b.33481">[
More Information]</a>
Morse, A., Cheng, T., Peacock, L., Mikulec, K.,
Little, D., Schindeler, A. (2016). RAP-011
augments callus formation in closed fractures in
rats. Journal of Orthopaedic Research, 34(2),
320-330. <a
href="http://dx.doi.org/10.1002/jor.22985">[Mor
e Information]</a>
2015
Britton, P., Macartney, K., Arbuckle, S., Little,
D., Kesson, A. (2015). A Rare Case of Q Fever
Osteomyelitis in a Child From Regional
Australia. Pediatric Infectious Diseases Society,
4(3), 28-31. <a
href="http://dx.doi.org/10.1093/jpids/piu095">[
More Information]</a>
Bobyn, J., Little, D., Gray, R., Schindeler, A.
(2015). Animal Models of Scoliosis. Journal of
Orthopaedic Research: a journal for
musculoskeletal investigation, 33(4), 458-467. <a
href="http://dx.doi.org/10.1002/jor.22797">[Mor
e Information]</a>
Cheng, T., Murphy, C., Ravarian, R., Dehghani,
F., Little, D., Schindeler, A. (2015).
Bisphosphonate-adsorbed ceramic nanoparticles
increase bone formation in an injectable carrier
for bone tissue engineering. Journal of Tissue
Engineering, 6, 1-9. <a
href="http://dx.doi.org/10.1177/2041731415609
448">[More Information]</a>
Morse, A., Yu, N., Peacock, L., Mikulec, K.,
Kramer, I., Kneissel, M., McDonald, M., Little,
D. (2015). Endochondral fracture healing with
external fixation in the Sost knockout mouse
results in earlier fibrocartilage callus removal
and increased bone volume fraction and strength.
Bone, 71, 155-163. <a
href="http://dx.doi.org/10.1016/j.bone.2014.10.0
Seime, T., Kolind, M., Mikulec, K., Summers,
M., Cantrill, L., Little, D., Schindeler, A. (2015).
Inducible cell labeling and lineage tracking
during fracture repair. Development, Growth and
Differentiation, 57(1), 10-23. <a
href="http://dx.doi.org/10.1111/dgd.12184">[Mo
re Information]</a>
Kolind, M., Bobyn, J., Matthews, B., Mikulec,
K., Aiken, A., Little, D., Kalajzici, I., Schindeler,
A. (2015). Lineage tracking of mesenchymal and
endothelial progenitors in BMP-induced bone
formation. Bone, 81, 53-59. <a
href="http://dx.doi.org/10.1016/j.bone.2015.06.0
23">[More Information]</a>
Schindeler, A., Yu, N., Cheng, T., Sullivan, K.,
Mikulec, K., Peacock, L., Matthews, R., Little,
D. (2015). Local delivery of the cationic steroid
antibiotic CSA-90 enables osseous union in a rat
open fracture model of Staphylococcus aureus
infection. Journal of Bone and Joint Surgery:
American Volume, 97(4), 302-309. <a
href="http://dx.doi.org/10.2106/JBJS.N.00840">
[More Information]</a>
Murphy, C., Schindeler, A., Cantrill, L.,
Mikulec, K., Peacock, L., Little, D. (2015).
PTH(1-34) Treatment Increases Bisphosphonate
Turnover in Fracture Repair in Rats. Journal of
Bone and Mineral Research, 30(6), 1022-1029.
<a
href="http://dx.doi.org/10.1002/jbmr.2424">[Mo
re Information]</a>
Summers, M., Quinlan (nee Edwards), K.,
Payne, J., Little, D., North, K., Schindeler, A.
(2015). Skeletal muscle and motor deficits in
Neurofibromatosis Type 1. Journal of
Musculoskeletal and Neuronal Interactions,
15(2), 161-170.
2014
Murphy, C., Schindeler, A., Gleeson, J., Yu, N.,
Cantrill, L., Mikulec, K., Peacock, L., O'Brien,
F., Little, D. (2014). A collagen-hydroxyapatite
scaffold allows for binding and co-delivery of
recombinant bone morphogenetic proteins and
bisphosphonates. Acta Biomaterialia, 10,
2250-2258. <a
href="http://dx.doi.org/10.1016/j.actbio.2014.01.
016">[More Information]</a>
El-Hoss, J., Cheng, T., Carpenter, E., Sullivan,
K., Deo, N., Mikulec, K., Little, D., Schindeler,
Publications for David Little
A. (2014). A combination of rhBMP-2
(recombinant human Bone Morphogenetic
Protein-2) and MEK (MAP kinase/ERK kinase)
inhibitor PD0325901 increases bone formation in
a murine model of neurofibromatosis type I
pseudarthrosis. Journal of Bone and Joint
Surgery: American Volume, 96(14), 1-11. <a
href="http://dx.doi.org/10.2106/JBJS.M.00862">
[More Information]</a>
Morse, A., McDonald, M., Kelly, N., Melville,
K., Schindeler, A., Kramer, I., Kneissel, M., Van
Der Meulen, M., Little, D. (2014). Mechanical
Load Increases in Bone Formation Via a
Sclerostin-Independent Pathway. Journal of
Bone and Mineral Research, 29(11), 2456-2467.
<a
href="http://dx.doi.org/10.1002/jbmr.2278">[Mo
re Information]</a>
Shen, K., Murphy, C., Chan, B., Kolind, M.,
Cheng, T., Cheng, T., Mikulec, K., Peacock, L.,
Xue, M., Park, S., Little, D., Jackson, C.,
Schindeler, A. (2014). Activated Protein C
(APC) can Increase Bone Anabolism via a
Protease Activated Receptor (PAR)1/2
Dependent Mechanism. Journal of Orthopaedic
Research, 32(12), 1549-1556. <a
href="http://dx.doi.org/10.1002/jor.22726">[Mor
e Information]</a>
El-Hoss, J., Kolind, M., Jackson, M., Deo, N.,
Mikulec, K., McDonald, M., Little, C., Little, D.,
Schindeler, A. (2014). Modulation of
endochondral ossification by MEK inhibitors
PD0325901 and AZD6244 (Selumetinib). Bone,
59, 151-161. <a
href="http://dx.doi.org/10.1016/j.bone.2013.11.0
13">[More Information]</a>
Gray, K., Gibbons, P., Little, D., Burns, J.
(2014). Bilateral clubfeet are highly correlated: a
cautionary tale for researchers. Clinical
Orthopaedics and Related Research, 472(11),
3517-3522. <a
href="http://dx.doi.org/10.1007/s11999-014-377
6-6">[More Information]</a>
Gray, K., Pacey, V., Gibbons, P., Little, D.,
Burns, J. (2014). Interventions for congenital
talipes equinovarus (clubfoot) (Review).
Cochrane Database of Systematic Reviews, 2014
(8), 1-63. <a
href="http://dx.doi.org/10.1002/14651858.CD00
8602.pub3">[More Information]</a>
Gray, K., Burns, J., Little, D., Bellemore, M.,
Gibbons, P. (2014). Is tibialis anterior tendon
transfer effective for recurrent clubfoot? Clinical
Orthopaedics and Related Research, 472(2),
750-758. <a
href="http://dx.doi.org/10.1007/s11999-013-328
7-x">[More Information]</a>
Cheng, T., Murphy, C., Cantrill, L., Mikulec, K.,
Carpenter, C., Schindeler, A., Little, D. (2014).
Local delivery of recombinant human bone
morphogenetic proteins and bisphosphonate via
sucrose acetate isobutyrate can prevent femoral
head collapse in Legg-Calve-Perthes disease: a
pilot study in pigs. International Orthopaedics,
38(7), 1527-1533. <a
href="http://dx.doi.org/10.1007/s00264-013-225
5-0">[More Information]</a>
Bobyn, J., Rasch, A., Kathy, M., Little, D.,
Schindeler, A. (2014). Maximizing bone
formation in posterior spine fusion using
rhBMP-2 and zoledronic acid in wild type and
NF1 deficient mice. Journal of Orthopaedic
Research, 32(8), 1090-1094. <a
href="http://dx.doi.org/10.1002/jor.22628">[Mor
e Information]</a>
Skowno, J., Quick, T., Carpenter, E., de Lima, J.,
Gibbons, P., Little, D. (2014). Near-infrared
spectroscopy for detection of vascular
compromise in paediatric supracondylar
fractures. Physiological Measurement, 35(3),
471-481. <a
href="http://dx.doi.org/10.1088/0967-3334/35/3/
471">[More Information]</a>
Sullivan, K., El-Hoss, J., Quinlan (nee Edwards),
K., Deo, N., Garton, F., Seto, J., Gdalevitch, M.,
Turner, N., Cooney, G., Kolanczyk, M., North,
K., Little, D., Schindeler, A. (2014). NF1 is a
critical regulator of muscle development and
metabolism. Human Molecular Genetics, 23(5),
1250-1259. <a
href="http://dx.doi.org/10.1093/hmg/ddt515">[
More Information]</a>
Casanova, M., Schindeler, A., Little, D., Muller,
R., Schneider, P. (2014). Quantitative
phenotyping of bone fracture repair: a review.
BoneKEy Reports, 3, 1-8. <a
href="http://dx.doi.org/10.1038/bonekey.2014.45
">[More Information]</a>
Yu, N., Gdalevitch, M., Murphy, C., Mikulec,
K., Peacock, L., Fitzpatrick, J., Cantrill, L.,
Ruys, A., Cooper-White, J., Little, D.,
Schindeler, A. (2014). Spatial control of bone
formation using a porous polymer scaffold
co-delivering anabolic rhbmp-2 and
anti-resorptive agents. European Cells and
Materials, 27, 98-111.
Gray, K., Barnes, E., Gibbons, P., Little, D.,
Burns, J. (2014). Unilateral versus bilateral
clubfoot: an analysis of severity and correlation.
Journal of Pediatric Orthopaedics. Part B,
23(5), 397-399. <a
href="http://dx.doi.org/10.1097/BPB.000000000
0000064">[More Information]</a>
2013
Cheng, T., Valtchev, P., Murphy, C., Cantrill, L.,
Publications for David Little
Dehghani, F., Little, D., Schindeler, A. (2013). A
sugar-based phase-transitioning delivery system
for bone tissue-engineering. European Cells and
Materials, 26, 208-221. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=24146213">[More Information]</a>
Stevenson, D., Little, D., Armstrong, L.,
Crawford, A., Eastwood, D., Friedman, J.,
Greggi, T., Gutierrez, G., Hunter-Schaedle, K.,
Kendler, D., Schindeler, A., et al (2013).
Approaches to Treating NF1 Tibial
Pseudarthrosis: Consensus From the Children's
Tumor Foundation NF1 Bone Abnormalities
Consortium. Journal of Pediatric Orthopaedics,
33(3), 269-275. <a
href="http://dx.doi.org/10.1097/BPO.0b013e318
28121b8">[More Information]</a>
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=23444237">[More Information]</a>
Sousa, D., McDonald, M., Mikulec, K., Peacock,
L., Herzog, H., Lamghari, M., Little, D.,
Baldock, P. (2013). Neuropeptide Y modulates
fracture healing through Y1 receptor signaling.
Journal of Orthopaedic Research, 31(10),
1570-1578. <a
href="http://dx.doi.org/10.1002/jor.22400">[Mor
e Information]</a>
Gray, K., Burns, J., Little, D., Bellemore, M.,
Gibbons, P. (2013). Objective assessment of
tibialis anterior tendon transfer surgery in
clubfoot. APA Conference 2013 'New Moves',
Melbourne: Australian Physiotherapy
Association.
Gray, K., Gibbons, P., Little, D., Barnes, E.,
Burns, J. (2013). Are bilateral and unilateral
clubfeet comparable? APA Conference 2013
'New Moves', Melbourne: Australian
Physiotherapy Association.
Bobyn, J., Rasch, A., Little, D., Schindeler, A.
(2013). Posterolateral inter-transverse lumbar
fusion in a mouse model. Journal of Orthopaedic
Surgery and Research, 8(1), 1-9. <a
href="http://dx.doi.org/10.1186/1749-799X-8-2"
>[More Information]</a>
Bosemark, P., Isaksson, H., McDonald, M.,
Little, D., Tägil, M. (2013). Augmentation of
autologous bone graft by a combination of bone
morphogenic protein and bisphosphonate
increased both callus volume and strength. Acta
Orthopaedica, 84(1), 106-111. <a
href="http://dx.doi.org/10.3109/17453674.2013.
773123">[More Information]</a>
Padhye, B., Dalla-Pozza, L., Little, D., Munns,
C. (2013). Use of Zoledronic Acid for Treatment
of Chemotherapy Related Osteonecrosis in
Children and Adolescents: A Retrospective
Analysis. Pediatric Blood & Cancer, 60(9),
1539-1545. <a
href="http://dx.doi.org/10.1002/pbc.24563">[Mo
re Information]</a>
Murphy, C., O'Brien, F., Little, D., Schindeler,
A. (2013). Cell-scaffold interactions in the bone
tissue engineering triad. European Cells and
Materials, 26, 120-132. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=24052425">[More Information]</a>
Schindeler, A., Kolind, M., Little, D. (2013).
Cellular Transitions and Tissue Engineering.
Cellular Reprogramming, 15(2), 101-106. <a
href="http://dx.doi.org/10.1089/cell.2012.0054">
[More Information]</a>
McDonald, M., Morse, A., Mikulec, K., Peacock,
L., Baldock, P., Kostenuik, P., Little, D. (2013).
Matrix Metalloproteinase - Driven Endochondral
Fracture Union Proceeds Independently of
Osteoclast Activity. Journal of Bone and
Mineral Research, 28(7), 1550-1560. <a
href="http://dx.doi.org/10.1002/jbmr.1889">[Mo
re Information]</a>
Yu, N., Schindeler, A., Peacock, L., Mikulec, K.,
Fitzpatrick, J., Ruys, A., Cooper-White, J., Little,
D. (2013). Modulation of anabolic and catabolic
responses via a porous polymer scaffold
manufactured using thermally induced phase
separation. European Cells and Materials, 25,
190-203. <a
2012
El-Hoss, J., Sullivan, K., Cheng, T., Yu, N.,
Bobyn, J., Peacock, L., Mikulec, K., Baldock, P.,
Alexander, I., Schindeler, A., Little, D. (2012). A
murine model of neurofibromatosis type 1 tibial
pseudarthrosis featuring proliferative fibrous
tissue and osteoclast-like cells. Journal of Bone
and Mineral Research, 27(1), 68-78. <a
href="http://dx.doi.org/10.1002/jbmr.528">[Mor
e Information]</a>
Gibbons, P., Little, D., Burns, J., Gray, K.
(2012). Biomechanical assessment of children
requiring tibialis anterior surgical tendon transfer
for residual congenital talipes equinovarus. 3rd
Congress of the International Foot and Ankle
Biomechanics Community. BioMed Central.
Young, M., Little, D., Kim, H. (2012). Evidence
for using bisphosphonate to treat
Legg-Calve-Perthes disease. Clinical
Orthopaedics and Related Research, 470(9),
2462-2475. <a
href="http://dx.doi.org/10.1007/s11999-011-224
0-0">[More Information]</a>
McDonald, M., Morse, A., Mikulec, K., Peacock,
L., Yu, N., Baldock, P., Birke, O., Liu, M., Ke,
H., Little, D. (2012). Inhibition of Sclerostin by
Publications for David Little
Systemic Treatment with Sclerostin Antibody
Enhances Healing of Proximal Tibial Defects in
Ovariectomized Rats. Journal of Orthopaedic
Research: a journal for musculoskeletal
investigation, 30(10), 1541-1548. <a
href="http://dx.doi.org/10.1002/jor.22109">[Mor
e Information]</a>
Cairns, D., Liu, R., Sen, M., Canner, J.,
Schindeler, A., Little, D., Zeng, L. (2012).
Interplay of Nkx3.2, Sox9 and Pax3 Regulates
Chondrogenic Differentiation of Muscle
Progenitor Cells. PloS One, 7(7), 1-17. <a
href="http://dx.doi.org/10.1371/journal.pone.003
9642">[More Information]</a>
Gray, K., Pacey, V., Gibbons, P., Little, D.,
Frost, C., Burns, J. (2012). Interventions for
congenital talipes equinovarus (clubfoot)
(Review). Cochrane Database of Systematic
Reviews, 4(2012), 1-27. <a
href="http://dx.doi.org/10.1002/14651858.CD00
8602.pub2">[More Information]</a>
Yu, N., Schindeler, A., Tagil, M., Ruys, A.,
Little, D. (2012). Use of BMPs and
bisphosphonates to improve bone fracture
healing. Frontiers in Bioscience (Elite Edition),
4E(7), 2647-2653. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=22652667">[More Information]</a>
2011
El-Hoss, J., Micallef, A., Fairfull-Smith, K.,
Bottle, S., Little, D., Schindeler, A. (2011).
Assessment of Tumor Prevention in Type 1
Neurofibromatosis using a Nitroxide Compound.
Free Radicals and Antioxidants, 1(3), 13-18.
Wilkinson, J., Little, D. (2011). Bisphosphonates
in orthopedic applications. Bone, 49(1), 95-102.
<a
href="http://dx.doi.org/10.1016/j.bone.2011.01.0
09">[More Information]</a>
McDonald, M., Morse, A., Peacock, L., Mikulec,
K., Schindeler, A., Little, D. (2011).
Characterization of the Bone Phenotype and
Fracture Repair in Osteopetrotic Incisors Absent
Rats. Journal of Orthopaedic Research: a
journal for musculoskeletal investigation, 29(5),
726-733. <a
href="http://dx.doi.org/10.1002/jor.21293">[Mor
e Information]</a>
Schindeler, A., Birke, O., Yu, N., Morse, A.,
Ruys, A., Baldock, P., Little, D. (2011). Distal
tibial fracture repair in a neurofibromatosis type
1-deficient mouse treated with recombinant bone
morphogenetic protein and a bisphosphonate.
Journal of Bone and Joint Surgery: British
Volume, 93 B (8), 1134-1139. <a
href="http://dx.doi.org/10.1302/0301-620X.93B
8.25940">[More Information]</a>
Birke, O., Davies, N., Latimer, M., Little, D.,
Bellemore, M. (2011). Experience With the
Fassier-Duval Telescopic Rod: First 24
Consecutive Cases With a Minimum of 1-Year
Follow-up. Journal of Pediatric Orthopaedics,
31(4), 458-464. <a
href="http://dx.doi.org/10.1097/BPO.0b013e318
21bfb50">[More Information]</a>
Little, D., Kim, H. (2011). Future Biologic
Treatments for Perthes Disease. Orthopedic
Clinics of North America, 42(3), 423-427. <a
href="http://dx.doi.org/10.1016/j.ocl.2011.03.00
1">[More Information]</a>
Sullivan, K., El-Hoss, J., Little, D., Schindeler,
A. (2011). JNK inhibitors increase osteogenesis
in Nf1-deficient cells. Bone, 49(6), 1311-1316.
<a
href="http://dx.doi.org/10.1016/j.bone.2011.09.0
43">[More Information]</a>
Liu, R., Birke, O., Morse, A., Peacock, L.,
Mikulec, K., Little, D., Schindeler, A. (2011).
Myogenic progenitors contribute to open but not
closed fracture repair. BMC Musculoskeletal
Disorders, 12, 288 - 1-288 - 9. <a
href="http://dx.doi.org/10.1186/1471-2474-12-2
88">[More Information]</a>
Gray, K., Gibbons, P., Little, D., Burns, J.
(2011). Objective differences in children with
congenital talipes equinovarus who require
tibialis anterior tendon transfer compared to
those who don’t. APA Physiotherapy Conference
2011, NA.
Little, D., Kim, H. (2011). Potential for
Bisphosphonate Treatment in
Legg-Calve-Perthes Disease. Journal of
Pediatric Orthopaedics, 31(SUPPL. 2),
S182-S188. <a
href="http://dx.doi.org/10.1097/BPO.0b013e318
223b541">[More Information]</a>
Birke, O., Mitchell, P., Onikul, E., Little, D.
(2011). The Effect of Hip Position Upon the
Location of the Sciatic Nerve: An MRI Study.
Journal of Pediatric Orthopaedics, 31(2),
165-169. <a
href="http://dx.doi.org/10.1097/BPO.0b013e318
20a1345">[More Information]</a>
Sim, P., Johannesen, J., Briody, J., McQuade,
M., Hsu, B., Bridge, C., Little, D., Cowell, C.,
Munns, C. (2011). Zoledronic acid improves
bone mineral density, reduces bone turnover and
improves skeletal architecture over 2 years of
treatment in children with secondary
osteoporosis. Bone, 49(5), 939-943. <a
href="http://dx.doi.org/10.1016/j.bone.2011.07.0
31">[More Information]</a>
Yang, N., Schindeler, A., McDonald, M., Seto,
Publications for David Little
J., Houweling, P., Lek, M., Hogarth, M., Morse,
A., Raftery, J., Balasuriya, D., Berman, Y.,
Quinlan (nee Edwards), K., Little, D., North, K.,
et al (2011). α-Actinin-3 deficiency is associated
with reduced bone mass in human and mouse.
Bone, 49(4), 790-798. <a
href="http://dx.doi.org/10.1016/j.bone.2011.07.0
09">[More Information]</a>
href="http://dx.doi.org/10.1002/14651858.CD00
8602">[More Information]</a>
2010
Birke, O., Schindeler, A., Ramachandran, M.,
Cowell, C., Munns, C., Bellemore, M., Little, D.
(2010). Preliminary experience with the
combined use of recombinant bone
morphogenetic protein and bisphosphonates in
the treatment of congenital pseudarthrosis of the
tibia. Journal of Children's Orthopaedics, 4(6),
507-517. <a
href="http://dx.doi.org/10.1007/s11832-010-029
3-3">[More Information]</a>
Ferri-de-Barros, F., Little, D., Bridge, C.,
Cummine, J., Cree, A. (2010). Atlantoaxial and
Craniocervical Arthrodesis in Children: A
Tomographic Study Comparing Suitability of C2
Pedicles and C2 Laminae for Screw Fixation.
Spine, 35(3), 291-293. <a
href="http://dx.doi.org/10.1097/BRS.0b013e318
1afea7d">[More Information]</a>
Yu, N., Schindeler, A., Little, D., Ruys, A.
(2010). Biodegradable poly(alpha-hydroxy acid)
polymer scaffolds for bone tissue engineering.
Journal of Biomedical Materials Research. Part
B: Applied Biomaterials, 93B(1), 285-295. <a
href="http://dx.doi.org/10.1002/jbm.b.31588">[
More Information]</a>
Goldhahn, J., Little, D., Mitchell, P., Fazzalari,
N., Reid, I., Aspenberg, P., Marsh, D., Augat, P.,
Bavonratanavech, S., Bostrom, M., Dunstan, C.,
et al (2010). Evidence for anti-osteoporosis
therapy in acute fracture
situations-Recommendations of a
multidisciplinary workshop of the International
Society for Fracture Repair. Bone, 46(2),
267-271. <a
href="http://dx.doi.org/10.1016/j.bone.2009.10.0
04">[More Information]</a>
Yu, N., Schindeler, A., Peacock, L., Mikulec, K.,
Baldock, P., Ruys, A., Little, D. (2010). In vivo
local co-delivery of recombinant human bone
morphogenetic protein-7 and pamidronate via
poly-D, L-lactic acid. European Cells and
Materials, 20, 431-442. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=21181649">[More Information]</a>
Tagil, M., McDonald, M., Morse, A., Peacock,
L., Mikulec, K., Maddock (nee Amanat), N.,
Godfrey, C., Little, D. (2010). Intermittent
PTH(1-34) does not increase union rates in open
rat femoral fractures and exhibits attenuated
anabolic effects compared to closed fractures.
Bone, 46(3), 852-859. <a
href="http://dx.doi.org/10.1016/j.bone.2009.11.0
09">[More Information]</a>
Gray, K., Pacey, V., Gibbons, P., Little, D.,
Burns, J. (2010). Interventions for congenital
talipes equinovarus (Protocol). Cochrane
Database of Systematic Reviews, 7(CD008602),
CD008602-1-CD008602-9. <a
Kumar, J., Ramachandran, M., Little, D., Zenios,
M. (2010). Pelvic osteomyelitis in children.
Journal of Pediatric Orthopaedics, 19(1), 38-41.
<a
href="http://dx.doi.org/10.1097/BPB.0b013e328
332f4b5">[More Information]</a>
Schindeler, A., Morse, A., Peacock, L., Mikulec,
K., Yu, N., Liu, R., Kijumnuayporn, S.,
McDonald, M., Baldock, P., Ruys, A., Little, D.
(2010). Rapid cell culture and pre-clinical
screening of a transforming growth factor-beta
(TGF-beta) inhibitor for orthopaedics. BMC
Musculoskeletal Disorders, 11(105),
105-1-105-9. <a
href="http://dx.doi.org/10.1186/1471-2474-11-1
05">[More Information]</a>
Zreiqat, H., Ramaswamy, Y., Wu, C.,
Paschalidis, A., Lu, Z., James, B., Birke, O.,
McDonald, M., Little, D., Dunstan, C. (2010).
The incorporation of strontium and zinc into a
calcium-silicon ceramic for bone tissue
engineering. Biomaterials, 31(12), 3175-3184.
<a
href="http://dx.doi.org/10.1016/j.biomaterials.20
10.01.024">[More Information]</a>
Liu, R., Schindeler, A., Little, D. (2010). The
potential role of muscle in bone repair. Journal
of Musculoskeletal and Neuronal Interactions,
10(1), 71-76. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=20190382">[More Information]</a>
2009
Kakar, S., Little, D., Einhorn, T. (2009). Can we
improve fixation and outcomes in the treatment
of femoral neck fractures? The use of
pharmaceuticals. Journal of Orthopaedic
Trauma, 23(6), 413-421. <a
href="http://dx.doi.org/10.1097/BOT.0b013e318
1ac64a0">[More Information]</a>
Liu, R., Ginn, S., Lek, M., North, K., Alexander,
I., Little, D., Schindeler, A. (2009). Myoblast
sensitivity and fibroblast insensitivity to
osteogenic conversion by BMP-2 correlates with
the expression of Bmpr-1 a. BMC
Publications for David Little
Musculoskeletal Disorders, 10, 51-1-51-12. <a
href="http://dx.doi.org/10.1186/1471-2474-10-5
1">[More Information]</a>
Baldock, P., Lee, N., Driessler, F., Lin, S.,
Allison, S., Stehrer, B., Lin, E., Zhang, L., et al,
Little, D. (2009). Neuropeptide Y Knockout
Mice Reveal a Central Role of NPY in the
Coordination of Bone Mass to Body Weight.
PloS One, 4(12), e8415-1-e8415-9. <a
href="http://dx.doi.org/10.1371/journal.pone.000
8415">[More Information]</a>
Elefterious, F., Kolanczyk, M., Schindeler, A.,
Viskochil, D., Hock, J., Schorry, E., Crawford,
A., Friedman, J., Little, D., Peltonen, J., et al
(2009). Skeletal Abnormalities in
Neurofibromatosis Type 1: Approaches to
Therapeutic Options. American Journal of
Medical Genetics. Part A, 149(10), 2327-2338.
<a
href="http://dx.doi.org/10.1002/ajmg.a.33045">[
More Information]</a>
Nguyen, K., Briody, J., McQuade, M., Little, D.,
Cowell, C., Munns, C. (2009). Systemic effects
of zoledronic acid in children with traumatic
femoral head avascular necrosis and
Legg-Calve-Perthes disease. Bone, 45(5),
898-902. <a
href="http://dx.doi.org/10.1016/j.bone.2009.04.2
55">[More Information]</a>
Schindeler, A., Liu, R., Little, D. (2009). The
contribution of different cell lineages to bone
repair: exploring a role for muscle stem cells.
Differentiation, 77(1), 12-18. <a
href="http://dx.doi.org/10.1016/j.diff.2008.09.00
7">[More Information]</a>
2008
Yu, N., Ruys, A., Zenios, M., Godfrey, C.,
McDonald, M., Kiely, P., Mikulec, K., Little, D.,
Schindeler, A. (2008). Bisphosphonate-Laden
Acrylic Bone Cement: Mechanical Properties,
Elution Performance, and In Vivo Activity.
Journal of Biomedical Materials Research. Part
B: Applied Biomaterials, 87B(2), 482-491. <a
href="http://dx.doi.org/10.1002/jbm.b.31130">[
More Information]</a>
McDonald, M., Dulai, S., Godfrey, C., Maddock
(nee Amanat), N., Sztynda, T., Little, D. (2008).
Bolus or weekly zoledronic acid administration
does not delay endochondral fracture repair but
weekly dosing enhances delays in hard callus
remodeling. Bone, 43(4), 653-662. <a
href="http://dx.doi.org/10.1016/j.bone.2008.05.0
19">[More Information]</a>
Schindeler, A., McDonald, M., Little, D., Bokka,
P. (2008). Bone remodeling during fracture
repair: The cellular picture. Seminars in Cell and
Developmental Biology, 19(5), 459-466. <a
href="http://dx.doi.org/10.1016/j.semcdb.2008.0
7.004">[More Information]</a>
Little, D. (2008). Humanising a Mouse Gene for
Human Therapeutics - Lessons From
Denosumab. Journal of Bone and Mineral
Research, 24, 179-81. <a
href="http://dx.doi.org/10.1359/jbmr.081221">[
More Information]</a>
Schindeler, A., Ramachandran, M., Godfrey, C.,
Morse, A., McDonald, M., Mikulec, K., Little,
D. (2008). Modeling Bone Morphogenetic
Protein and Bisphosphonate Combination
Therapy in Wild-Type and Nf1 Haploinsufficient
Mice. Journal of Orthopaedic Research: a
journal for musculoskeletal investigation, 26(1),
65-74. <a
href="http://dx.doi.org/10.1002/jor.20481">[Mor
e Information]</a>
Schindeler, A., Morse, A., Harry, L., Godfrey,
C., Mikulec, K., McDonald, M., Gasser, J.,
Little, D. (2008). Models of Tibial Fracture
Healing in Normal and Nf1-Deficient Mice.
Journal of Orthopaedic Research: a journal for
musculoskeletal investigation, 26(8), 1053-1060.
<a
href="http://dx.doi.org/10.1002/jor.20628">[Mor
e Information]</a>
McDonald, M., Tägil, M., Morse, A., Godfrey,
C., Maddock (nee Amanat), N., Little, D. (2008).
PTH treatment increases fracture callus size and
strength more effectively in closed than open
fractures. Bone, 42(Supplement 1), S78-S79. <a
href="http://dx.doi.org/10.1016/j.bone.2007.12.1
45">[More Information]</a>
Schindeler, A., Little, D. (2008). Recent insights
into bone development, homeostasis, and repair
in type 1 neurofibromatosis (NF1). Bone, 42(4),
616-622. <a
href="http://dx.doi.org/10.1016/j.bone.2007.11.0
06">[More Information]</a>
Maddock (nee Amanat), N., He, L., Swain, M.,
Little, D. (2008). The effect of zoledronic acid
on the intrinsic material properites of healing
bone: An indentation study. Medical Engineering
and Physics, 30(7), 843-847. <a
href="http://dx.doi.org/10.1016/j.medengphy.200
7.09.008">[More Information]</a>
Chang, A., Hook, J., Lemckert, F., McDonald,
M., Nguyen, M., Hardeman, E., Little, D.,
Gunning, P., Reddel, R. (2008). The murine
stanniocalcin 2 gene is a negative regulator of
postnatal growth. Endocrinology, 149(5),
2403-2410. <a
href="http://dx.doi.org/10.1210/en.2007-1219">[
More Information]</a>
2007
Munns, C., Rajab, M., Hong, J., Briody, J.,
Publications for David Little
Hoegler, W., McQuade, M., Little, D., Cowell,
C. (2007). Acute phase response and mineral
status following low dose intravenous zoledronic
acid in children. Bone, 41, 366-370. <a
href="http://dx.doi.org/10.1016/j.bone.2007.05.0
02">[More Information]</a>
Schindeler, A., Little, D. (2007). Bisphosphonate
action: Revelations and deceptions from in vitro
studies. Journal of Pharmaceutical Sciences,
96(8), 1872-1878. <a
href="http://dx.doi.org/10.1002/jps.20904">[Mor
e Information]</a>
Kiely, P., Ward, K., Bellemore, M., Briody, J.,
Cowell, C., Little, D. (2007). Bisphosphonate
rescue in distraction osteogenesis: a case series.
Journal of Pediatric Orthopaedics, 27(4),
467-471. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17513972">[More Information]</a>
Dulai, S., Briody, J., Schindeler, A., North, K.,
Cowell, C., Little, D. (2007). Decreased bone
mineral density in neurofibromatosis type 1:
results from a pediatric cohort. Journal of
Pediatric Orthopaedics, 27(4), 472-475. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17513973">[More Information]</a>
Zenios, M., Ramachandran, M., Milne, B., Little,
D., Smith, N. (2007). Intraoperative stability
testing of lateral-entry pin fixation of pediatric
supracondylar humeral fractures. Journal of
Pediatric Orthopaedics, 27(6), 695-702. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17717474">[More Information]</a>
Ramachandran, M., Ward, K., Brown, R.,
Munns, C., Cowell, C., Little, D. (2007).
Intravenous bisphosphonate therapy for
traumatic osteonecrosis of the femoral head in
adolescents. Journal of Bone and Joint
Surgery-American Volume, 89(8), 1727-1734. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17671011">[More Information]</a>
Kumar, V., Kumar, D., Howman-Giles, R.,
Little, D. (2007). Is (99m)Tc-labelled
pamidronate a better agent than
(99m)Tc-medronate for bone imaging? Nuclear
Medicine Communications, 28(2), 101-107. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17198350">[More Information]</a>
Kumar, V., Kumar, D., Howman-Giles, R.,
Little, D. (2007). Is Tc-99m-labelled
pamidronate a better agent than
Tc-99m-medronate for bone imaging? Nuclear
Medicine Communications, 28(2), 101-107.
Baldock, P., Allison, S., Lundberg, P., Lee, N.,
Slack, K., Lin, E., Enriquez, R., McDonald, M.,
Zhang, L., During, M., Little, D., et al (2007).
Novel role of y1 receptors in the coordinated
regulation of bone and energy homeostasis.
Journal of Biological Chemistry, 282(26),
19092-19102. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17491016">[More Information]</a>
Maddock (nee Amanat), N., McDonald, M.,
Godfrey, C., Bilston, L., Little, D. (2007).
Optimal timing of a single dose of zoledronic
acid to increase strength in rat fracture repair.
Journal of Bone and Mineral Research, 22(6),
867-876. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17371160">[More Information]</a>
Zenios, M., Ramachandran, M., Axt, M.,
Gibbons, P., Peat, J., Little, D. (2007). Posterior
sloping angle of the capital femoral physis:
interobserver and intraobserver reliability testing
and predictor of bilaterality. Journal of Pediatric
Orthopaedics, 27(7), 801-804. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17878788">[More Information]</a>
Little, D., Ramachandran, M., Schindeler, A.
(2007). The anabolic and catabolic responses in
bone repair. Journal of Bone and Joint Surgery:
British Volume, 89(4), 425-433. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17463107">[More Information]</a>
Nelson, D., Zenios, M., Ward, K.,
Ramachandran, M., Little, D. (2007). The
deformity index as a predictor of final
radiological outcome in Perthes' disease. Journal
of Bone and Joint Surgery: British Volume,
89(10), 1369-1374. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17957080">[More Information]</a>
2006
Little, D., Ward, K., Kiely, P., Bellemore, M.,
Briody, J., Cowell, C. (2006). Bisphosphonate
rescue in distraction osteogenesis: A case series.
Bone, 38(3, Supplement 1), S80-S80.
Schindeler, A., Ramachandran, M., Little, D.
(2006). BMP-2 treatment produces an attenuated
response in a mouse model of type 1
neurofibromatosis.
Tägil, M., W-Dahl, A., Astrand, J., Little, D.,
Toksvig-Larsen, S. (2006). Decreasing the
catabolic response by a single bisphosphonate
infusion shortens the healing time in
Publications for David Little
hemicallotasis operations.
Bransford, R., Goergens, E., Briody, J., Maddock
(nee Amanat), N., Cree, A., Little, D. (2006).
Effect of zoledronic acid in an L6-L7 rabbit
spine fusion model. European Spine Journal,
Online Article, 1-6. <a
href="http://dx.doi.org/10.1007/s00586-006-021
2-y">[More Information]</a>
McDonald, M., Dulai, S., Godfrey, C., Sztynda,
T., Little, D. (2006). Endochondral repair and
development proceed normally during zoledronic
acid treatment.
Kumar, D., Kumar, V., Little, D.,
Howman-Giles, R., Wong, E., Ali, S. (2006).
Evaluation of biodistribution by local versus
systemic administration of (99m)Tc-labeled
pamidronate. Journal of orthopaedic science,
11(5), 512-520. <a
href="http://dx.doi.org/10.1007/s00776-006-104
6-5">[More Information]</a>
Baldock, P., Allison, S., McDonald, M.,
Sainsbury, A., Enriquez, R., Little, D., Eisman,
J., Gardiner, E., Herzog, H. (2006).
Hypothalamic regulation of cortical bone mass:
opposing activity of Y2 receptor and leptin
pathways. Journal of Bone and Mineral
Research, 21(10), 1600-1607. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16995815">[More Information]</a>
Maddock (nee Amanat), N., McDonald, M.,
Godfrey, C., Bilston, L., Little, D. (2006).
Optimal timing of bolus intravenous zoledronic
acid in a rat fracture model. Bone, 38, S43-S43.
Schindeler, A., Little, D. (2006). Osteoclasts but
not osteoblasts are affected by bispbospbonate
bound to a calcified substrate.
Schindeler, A., Little, D. (2006). Ras-MAPK
signaling in osteogenic differentiation: friend or
foe? Journal of Bone and Mineral Research,
21(9), 1331-1338. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16939391">[More Information]</a>
McDonald, M., Dulai, S., Godfrey, C., Sztynda,
T., Little, D. (2006). Single dose zoledronic acid
treatment is superior to continuous treatment in
enhancing hard callus formation and strength
without delayed remodelling. <a
href="http://dx.doi.org/10.1016/j.bone.2005.12.0
60">[More Information]</a>
Jackson, R., McDonald, M., Nurcombe, V.,
Little, D., Cool, S. (2006). The use of heparan
sulfate to augment fracture repair in a rat fracture
model. Journal of Orthopaedic Research: a
journal for musculoskeletal investigation, 24(4),
636-644. <a
href="http://dx.doi.org/10.1002/jor.20103">[Mor
e Information]</a>
2005
Maddock (nee Amanat), N., Brown, R., Bilston,
L., Little, D. (2005). A single systemic dose of
pamidronate improves bone mineral content and
accelerates restoration of strength in a rat model
of fracture repair. Journal of Orthopaedic
Research: a journal for musculoskeletal
investigation, 23(5), 1029-34. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16140188">[More Information]</a>
Little, D., Bransford, R., McDonald, M.,
Godfrey, C., Maddock (nee Amanat), N. (2005).
Manipulation of the anabolic and catabolic
responses in a critical defect model with OP-1
and zoledronic acid. 2nd Joint Meeting of the
European Calcified Tissue Society and the
International Bone and Mineral Society, New
York: Elsevier Science.
Little, D., McDonald, M., Bransford, R.,
Godfrey, C., Maddock (nee Amanat), N. (2005).
Manipulation of the anabolic and catabolic
responses with OP-1 and zoledronic acid in a rat
critical defect model. Journal of Bone and
Mineral Research, 20(11), 2044-52. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16234978">[More Information]</a>
Schindeler, A., Little, D. (2005). Osteoclasts but
not osteoblasts are affected by a calcified surface
treated with zoledronic acid in vitro. Biochemical
and Biophysical Research Communications,
338(2), 710-716. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16243296">[More Information]</a>
Cowell, C., Little, D., Ward, K. (2005).
Quantification of metaphyseal modeling in
children treated with bisphosphonates. Bone,
36(6), 999-1002. <a
href="http://dx.doi.org/10.1016/j.bone.2005.02.0
16">[More Information]</a>
Smith, E., Little, D., Briody, J., McEvoy, A.,
Smith, N., Eisman, J., Gardiner, E. (2005).
Transient Disturbance in Physeal Morphology Is
Associated With Long-Term Effects of
Nitrogen-Containing Bisphosphonates in
Growing Rabbits. Journal of Bone and Mineral
Research, 20(10), 1731-1741. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16160731">[More Information]</a>
Bobyn, J., Hacking, S., Krygier, J., Harvey, E.,
Little, D., Tanzer, M. (2005). Zoledronic acid
causes enhancement of bone growth into porous
Publications for David Little
implants. Journal of Bone and Joint Surgery:
British Volume, 87-B (3), 416-420.
Little, D., McDonald, M., Sharpe, I., Peat, R.,
Williams, P., McEvoy, A. (2005). Zoledronic
acid improves femoral head sphericity in a rat
model of perthes disease. Journal of Orthopaedic
Research: a journal for musculoskeletal
investigation, 23(4), 862-868. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16023001">[More Information]</a>
McDonald, M., Dulai, S., Godfrey, C., Hamilton,
B., Little, D. (2005). Zoledronic acid treatment
enhances hard callus formation without delaying
endochondral repair in a rat fracture model.
Bone, 36(point P377-Mo), S305-S305.
2004
Maddock (nee Amanat), N., Brown, R., Bilston,
L., Little, D. (2004). A Single Systemic Dose Of
Pamidronate Increases Bone Mineral Content
And Strength Over Local Pamidronate
Administration Or Saline In A Rat Fracture
Model. Bone, 34, S46-S47.
Chia, J., Holland, A., Little, D., Cass, D. (2004).
Pelvic Fractures And Associated Injuries In
Children. Journal of Trauma, 56(1), 83-88.
Hogler, W., Yap, F., Little, D., Ambler, G.,
McQuade, M., Cowell, C. (2004). Short-Term
Safety Assessment In The Use Of Intravenous
Zoledronic Acid In Children. The Journal of
Pediatrics, 145(5), 701-704.
Smith, E., McEvoy, A., Little, D., Baldock, P.,
Eisman, J., Gardiner, E. (2004). Transient
Retention Of Endochondral Cartilaginous Matrix
With Bisphosphonate Treatment In A
Long-Term Rabbit Model Of Distraction
Osteogenesis. Journal of Bone and Mineral
Research, 19(10), 1698-1705.
2003
Uglow, M., Peat, R., Hile, M., Bilston, L., Smith,
E., Little, D. (2003). Low-Intensity Ultrasound
Stimulation in Distraction Osteogenesis in
Rabbits. Clinical Orthopaedics and Related
Research, 417, 303-312.
Little, D., Smith, N., Williams, P., Briody, J.,
Bilston, L., Smith, E., Gardiner, E., Cowell, C.
(2003). Zoledronic acid prevents osteopenia and
increases bone strength in a rabbit model of
distraction osteogenesis. Journal of Bone and
Mineral Research, 18(7), 1300-1307.
Little, D., Peat, R., McEvoy, A., Williams, P.,
Smith, E., Baldock, P. (2003). Zoledronic acid
treatment results in retention of femoral head
structure after traumatic osteonecrosis in young
Wistar rats. Journal of Bone and Mineral
Research, 18(11), 2016-2022.
2001
Little, D., Bilston, L., Cornell, M., Hile,, M.,
Briody, J., Cowell, C. (2001). Effect of
pamidronate on distraction osteogenesis and
fixator-related osteoporosis. Injury, 32.