Publications for Danuta Kalinowski
Publications for Danuta Kalinowski
2016
Chiang, S., Kovacevic, Z., Sahni, S., Lane, D.,
Merlot, A., Kalinowski, D., Huang, M.,
Richardson, D. (2016). Frataxin and the
molecular mechanism of mitochondrial
iron-loading in Friedreich's ataxia. Clinical
Science, 130(11), 853-870. <a
href="http://dx.doi.org/10.1042/CS20160072">[
More Information]</a>
Gutierrez, E., Seebacher, N., Arzuman, L.,
Kovacevic, Z., Lane, D., Richardson, V., Merlot,
A., Lok, H., Kalinowski, D., Sahni, S., Jansson,
P., Richardson, D. (2016). Lysosomal membrane
stability plays a major role in the cytotoxic
activity of the anti-proliferative agent,
di-2-pyridylketone
4,4-dimethyl-3-thiosemicarbazone (Dp44mT).
Biochimica et Biophysica Acta: international
journal of biochemistry and biophysics, 1863 (7
Pt A), 1665-1681. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
4.017">[More Information]</a>
Merlot, A., Shafie, N., Yu, Y., Richardson, V.,
Jansson, P., Sahni, S., Lane, D., Kovacevic, Z.,
Kalinowski, D., Richardson, D. (2016).
Mechanism of the induction of endoplasmic
reticulum stress by the anti-cancer agent,
di-2-pyridylketone
4,4-dimethyl-3-thiosemicarbazone (Dp44mT):
Activation of PERK/eIF2?, IRE1?, ATF6 and
calmodulin kinase. Biochemical Pharmacology,
109, 27-47. <a
href="http://dx.doi.org/10.1016/j.bcp.2016.04.00
1">[More Information]</a>
Al-Eisawi, Z., Stefani, C., Jansson, P., Arvind,
A., Sharpe, P., Basha, M., Iskander, G., Kumar,
N., Kovacevic, Z., Lane, D., Sahni, S.,
Richardson, D., Kalinowski, D., et al (2016).
Novel Mechanism of Cytotoxicity for the
Selective
Selenosemicarbazone, 2‑Acetylpyridine
4,4-Dimethyl-3selenosemicarbazone (Ap44mSe): Lysosomal
Membrane
Permeabilization. Journal of Medicinal
Chemistry, 59(1), 294-312. <a
href="http://dx.doi.org/10.1021/acs.jmedchem.5b
01399">[More Information]</a>
Kalinowski, D., Stefani, C., Toyokuni, S., Ganz,
T., Anderson, G., Subramaniam, N., Trinder, D.,
Chua, A., Jansson, P., Sahni, S., Lane, D.,
Merlot, A., Kovacevic, Z., Huang, M.,
Richardson, D., et al (2016). Redox cycling
metals: Pedaling their roles in metabolism and
their use in the development of novel
therapeutics. BBA: Biochimica et Biophysica
Acta - Molecular Cell Research, 1893 (4),
727-748. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
1.026">[More Information]</a>
Paluncic, J., Kovacevic, Z., Jansson, P.,
Kalinowski, D., Merlot, A., Huang, M., Lok, H.,
Sahni, S., Lane, D., Richardson, D. (2016).
Roads to melanoma: Key pathways and
emerging players in melanoma progression and
oncogenic signaling. Biochimica et Biophysica
Acta: international journal of biochemistry and
biophysics, 1863 (4), 770-784. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2016.0
1.025">[More Information]</a>
Sahni, S., Kovacevic, Z., Kalinowski, D., Huang,
M., Menezes, S., Krishan, S., Lane, D., Jansson,
P., Richardson, D. (2016). Targeting autophagy
in antitumor agent design: Furthering the
'lysosomal love' strategy. Future Medicinal
Chemistry, 8(7), 727-729. <a
href="http://dx.doi.org/10.4155/fmc-2016-0066"
>[More Information]</a>
Kovacevic, Z., Menezes, S., Sahni, S.,
Kalinowski, D., Bae, D., Lane, D., Richardson,
D. (2016). The metastasis suppressor, N-MYC
downstream-regulated gene-1 (NDRG1),
down-regulates the ErbB family of receptors to
inhibit downstream oncogenic signaling
pathways. Journal of Biological Chemistry,
291(3), 1029-1052.
Stacy, A., Palanimuthu, D., Bernhardt, P.,
Kalinowski, D., Jansson, P., Richardson, D.
(2016). Zinc(II)-Thiosemicarbazone Complexes
Are Localized to the Lysosomal Compartment
Where They Transmetallate with Copper Ions to
Induce Cytotoxicity. Journal of Medicinal
Chemistry, 59(10), 4965-4984. <a
href="http://dx.doi.org/10.1021/acs.jmedchem.6b
00238">[More Information]</a>
2015
Lane, D., Merlot, A., Huang, M., Bae, D.,
Jansson, P., Sahni, S., Kalinowski, D.,
Richardson, D. (2015). Cellular iron uptake,
trafficking and metabolism: Key molecules and
mechanisms and their roles in disease.
Biochimica et Biophysica Acta. General
Subjects, 1853 (5), 1130-1144. <a
href="http://dx.doi.org/10.1016/j.bbamcr.2015.0
1.021">[More Information]</a>
Stefani, C., Al-Eisawi, Z., Jansson, P.,
Kalinowski, D., Richardson, D. (2015).
Identification of differential anti-neoplastic
activity of copper bis(thiosemicarbazones) that is
mediated by intracellular reactive oxygen species
generation and lysosomal membrane
permeabilization. Journal of Inorganic
Biochemistry, 152, 20-37. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2015.
Publications for Danuta Kalinowski
08.010">[More Information]</a>
Potuckova, E., Roh, J., Machacek, M., Sahni, S.,
Stariat, J., Sestak, V., Jansova, H., Haskova, P.,
Jirkovska, A., Kalinowski, D., Richardson, D., et
al (2015). In Vitro Characterization of the
Pharmacological Properties of the Anti-Cancer
Chelator, Bp4eT, and Its Phase I Metabolites.
PloS One, 10(10), 1-20. <a
href="http://dx.doi.org/10.1371/journal.pone.013
9929">[More Information]</a>
Merlot, A., Kalinowski, D., Kovacevic, Z.,
Jansson, P., Lane, D., Sahni, S., Huang, M.,
Richardson, D. (2015). Making a case for
albumin - a highly promising drug-delivery
system. Future Medicinal Chemistry, 7(5),
553-556. <a
href="http://dx.doi.org/10.4155/fmc.15.15">[Mo
re Information]</a>
Sestak, V., Stariat, J., Cermanova, J., Potuckova,
E., Chladek, J., Roh, J., Bures, J., Jansova, H.,
Prusa, P., Sterba, M., Kalinowski, D.,
Richardson, D., et al (2015). Novel and potent
anti-tumor and anti-metastatic di-2-pyridylketone
thiosemicarbazones demonstrate marked
differences in pharmacology between the first
and second generation lead agents. Oncotarget,
6(40), 42411-42428. <a
href="http://dx.doi.org/10.18632/oncotarget.638
9">[More Information]</a>
Lui, G., Kovacevic, Z., Menezes, S., Kalinowski,
D., Merlot, A., Sahni, S., Richardson, D. (2015).
Novel Thiosemicarbazones Regulate the Signal
Transducer and Activator of Transcription 3
(STAT3) Pathway: Inhibition of Constitutive and
Interleukin 6-Induced Activation by Iron
Depletion. Molecular Pharmacology, 87(3),
543-560. <a
href="http://dx.doi.org/10.1124/mol.114.096529
">[More Information]</a>
Merlot, A., Sahni, S., Lane, D., Fordham, A.,
Pantarat, N., Hibbs, D., Richardson, V.,
Doddareddy, M., Ong, J., Huang, M.,
Richardson, D., Kalinowski, D. (2015).
Potentiating the cellular targeting and anti-tumor
activity of
Dp44mT via binding to human serum albumin:
two saturable
mechanisms of Dp44mT uptake by cells.
Oncotarget, 6(12), 10374-10398.
Jirkovska, A., Roh, J., Len�?ová-Popelová, O.,
Jirkovsky, E., Hrušková, K., Potuckova, E.,
Jansova, H., Haskova, P., Martinková, P., Eisner,
T., Kalinowski, D., Richardson, D., et al (2015).
Synthesis and analysis of novel analogues of
dexrazoxane and its open-ring hydrolysis product
for protection against anthracycline
cardiotoxicity in vitro and in vivo. Toxicology
Research, 4(4), 1098-1114. <a
href="http://dx.doi.org/10.1039/c5tx00048c">[M
ore Information]</a>
Lui, G., Kovacevic, Z., Richardson, V., Merlot,
A., Kalinowski, D., Richardson, D. (2015).
Targeting cancer by binding iron: Dissecting
cellular signaling pathways. Oncotarget, 6(22),
18748-18779.
Liu, W., Kovacevic, Z., Peng, Z., Jin, R., Wang,
P., Yue, F., Zheng, M., Huang, M., Jansson, P.,
Richardson, V., Kalinowski, D., Lane, D.,
Merlot, A., Sahni, S., Richardson, D. (2015). The
molecular effect of metastasis suppressors on Src
signaling and tumorigenesis: New therapeutic
targets. Oncotarget, 6(34), 35522-35541. <a
href="http://dx.doi.org/10.18632/oncotarget.584
9">[More Information]</a>
Liu, W., Yue, F., Zheng, M., Merlot, A., Bae, D.,
Huang, M., Lane, D., Jansson, P., Liu, G.,
Richardson, V., Sahni, S., Kalinowski, D.,
Kovacevic, Z., Richardson, D. (2015). The
proto-oncogene c-Src and its downstream
signaling pathways are inhibited by the
metastasis suppressor, NDRG1. Oncotarget,
6(11), 8851-8874.
Jansson, P., Kalinowski, D., Lane, D.,
Kovacevic, Z., Seebacher, N., Fouani, L., Sahni,
S., Merlot, A., Richardson, D. (2015). The
renaissance of polypharmacology in the
development of
anti-cancer therapeutics: Inhibition of the "Triad
of Death" in cancer by Di-2-pyridylketone
thiosemicarbazones. Pharmacological Research,
100, 255-260. <a
href="http://dx.doi.org/10.1016/j.phrs.2015.08.0
13">[More Information]</a>
2014
Filak, L., Kalinowski, D., Bauer, T., Richardson,
D., Arion, V. (2014). Effect of the piperazine
unit and metal-binding site position on the
solubility and anti-proliferative activity of
ruthenium(II)- and osmium(II)- arene complexes
of isomeric indolo[3,2-c]quinoline-piperazine
hybrids. Inorganic Chemistry, 53(13),
6934-6943. <a
href="http://dx.doi.org/10.1021/ic500825j">[Mo
re Information]</a>
Lane, D., Mills, T., Shafie, N., Merlot, A., Saleh
Moussa, R., Kalinowski, D., Kovacevic, Z.,
Richardson, D. (2014). Expanding horizons in
iron chelation and the treatment of cancer: Role
of iron in the regulation of ER stress and the
epithelial-mesenchymal transition. Biochimica et
Biophysica Acta-Reviews on Cancer, 1845 (2),
166-181. <a
href="http://dx.doi.org/10.1016/j.bbcan.2014.01.
005">[More Information]</a>
Publications for Danuta Kalinowski
Serda, M., Kalinowski, D., Rasko, N.,
Potuckova, E., Mrozek-Wilczkiewicz, A.,
Musiol, R., Małecki, J., Sajewicz, M., Ratuszna,
A., Muchowicz, A., Richardson, D., et al (2014).
Exploring the anti-cancer activity of novel
thiosemicarbazones generated through the
combination of retro-fragments: dissection of
critical structure-activity relationships. PloS One,
9(10), 1-15. <a
href="http://dx.doi.org/10.1371/journal.pone.011
0291">[More Information]</a>
Lok, H., Sahni, S., Richardson, V., Kalinowski,
D., Kovacevic, Z., Lane, D., Richardson, D.
(2014). Glutathione S-Transferase and MRP1
Form an Integrated System Involved in the
Storage and Transport of Dinitrosyl-Dithiolato
Iron Complexes in Cells. Free Radical Biology
and Medicine, 75, 14-29. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2014.07.002">[More Information]</a>
Fang, B., Kovacevic, Z., Park, K., Kalinowski,
D., Jansson, P., Lane, D., Sahni, S., Richardson,
D. (2014). Molecular Functions of the
Iron-Regulated Metastasis Suppressor, NDRG1,
and its Potential as a Molecular Target for
Cancer Therapy. Biochimica et Biophysica Acta.
Molecular and Cell Biology of Lipids, 1845 (1),
1-19. <a
href="http://dx.doi.org/10.1016/j.bbcan.2013.11.
002">[More Information]</a>
Ellis, S., Kalinowski, D., Leotta, L., Huang, M.,
Jelfs, P., Sintchenko, V., Richardson, D., Triccas,
J. (2014). Potent Anti-Mycobacterial Activity of
the Pyridoxal Isonicotinoyl Hydrazone
Analogue, 2-Pyridylcarboxaldehyde
Isonicotinoyl Hydrazone: A Lipophilic Transport
Vehicle for Isonicotinic Acid Hydrazide.
Molecular Pharmacology, 85(2), 269-278. <a
href="http://dx.doi.org/10.1124/mol.113.090357
">[More Information]</a>
href="http://dx.doi.org/10.1002/bmc.3080">[Mo
re Information]</a>
Potuckova, E., Hrušková, K., Bures, J.,
Kovarikova, P., Spirkova, I., Pravdıkova, K.,
Kolbabova, L., Hergeselova, T., Haskova, P.,
Jansova, H., Richardson, V., Lane, D.,
Kalinowski, D., Richardson, D., et al (2014).
Structure-Activity Relationships of Novel
Salicylaldehyde Isonicotinoyl Hydrazone (SIH)
Analogs: Iron Chelation, Anti-Oxidant and
Cytotoxic Properties. PloS One, 9(11), 1-17. <a
href="http://dx.doi.org/10.1371/journal.pone.011
2059">[More Information]</a>
Lukmantara, A., Kalinowski, D., Kumar, N.,
Richardson, D. (2014). Synthesis and biological
evaluation of 2-benzoylpyridine
thiosemicarbazones in a dimeric system:
Structure-activity relationship studies on their
anti-proliferative and iron chelation efficacy.
Journal of Inorganic Biochemistry, 141, 43-54.
<a
href="http://dx.doi.org/10.1016/j.jinorgbio.2014.
07.020">[More Information]</a>
Sahni, S., Bae, D., Lane, D., Kovacevic, Z.,
Kalinowski, D., Jansson, P., Richardson, D.
(2014). The metastasis suppressor, N-myc
downstream-regulated gene 1 (NDRG1), inhibits
stress-induced autophagy in cancer cells. The
Journal of Biological Chemistry, 289(14),
9692-9709. <a
href="http://dx.doi.org/10.1074/jbc.M113.52951
1">[More Information]</a>
Merlot, A., Kalinowski, D., Richardson, D.
(2014). Unraveling the mysteries of serum
albumin-more than just a serum protein.
Frontiers in Physiology, 5, 1-7. <a
href="http://dx.doi.org/10.3389/fphys.2014.0029
9">[More Information]</a>
2013
Potuckova, E., Jansova, H., Machacek, M.,
Vavrova, A., Haskova, P., Tichotova, L.,
Richardson, V., Kalinowski, D., Richardson, D.,
Simunek, T. (2014). Quantitative Analysis of the
Anti-Proliferative Activity of Combinations of
Selected Iron-Chelating Agents and Clinically
Used Anti-Neoplastic Drugs. PloS One, 9(2),
1-15. <a
href="http://dx.doi.org/10.1371/journal.pone.008
8754">[More Information]</a>
Stefani, C., Jansson, P., Gutierrez, E., Bernhardt,
P., Richardson, D., Kalinowski, D. (2013). Alkyl
Substituted 2'-Benzoylpyridine
Thiosemicarbazone Chelators with Potent and
Selective Anti-Neoplastic Activity: Novel
Ligands that Limit Methemoglobin Formation.
Journal of Medicinal Chemistry, 56(1), 357-370.
<a
href="http://dx.doi.org/10.1021/jm301691s">[M
ore Information]</a>
Stariat, J., Suprunova, V., Roh, J., Sestak, V.,
Eisner, T., Filipsky, T., Mladenka, P., Nobilis,
M., Simunek, T., Klimes, J., Kalinowski, D.,
Richardson, D., et al (2014). Simultaneous
determination of the novel thiosemicarbazone
anti-cancer agent, Bp4eT, and its main phase I
metabolites in plasma: application to a pilot
pharmacokinetic study in rats. Biomedical
Chromatography, 28(5), 621-629. <a
Walcourt, A., Kurantsin-Mills, J., Kwagyan, J.,
Adenuga, B., Kalinowski, D., Lovejoy, D., Lane,
D., Richardson, D. (2013). Anti-plasmodial
activity of aroylhydrazone and
thiosemicarbazone iron chelators: Effect on
erythrocyte membrane integrity, parasite
development and the intracellular labile iron
pool. Journal of Inorganic Biochemistry, 129,
43-51. <a
Publications for Danuta Kalinowski
href="http://dx.doi.org/10.1016/j.jinorgbio.2013.
08.007">[More Information]</a>
Merlot, A., Pantarat, N., Menezes, S., Sahni, S.,
Richardson, D., Kalinowski, D. (2013). Cellular
Uptake of the Antitumor Agent Dp44mT Occurs
via a Carrier/Receptor-Mediated Mechanism.
Molecular Pharmacology, 84(6), 911-924. <a
href="http://dx.doi.org/10.1124/mol.113.088393
">[More Information]</a>
Ford, S., Obeidy, P., Lovejoy, D., Bedford, M.,
Nichols, L., Chadwick, C., Tucker, O., Lui, G.,
Kalinowski, D., Jansson, P., Richardson, D., et al
(2013). Deferasirox (ICL670A) effectively
inhibits oesophageal cancer growth in vitro and
in vivo. British Journal of Pharmacology,
168(6), 1316-1328. <a
href="http://dx.doi.org/10.1111/bph.12045">[Mo
re Information]</a>
Stariat, J., Kovarikova, P., Kucera, R., Klimes,
J., Kalinowski, D., Richardson, D., Ketola, R.
(2013). Identification of in vitro metabolites of
the novel anti-tumor thiosemicarbazone, DpC,
using ultra-high performance liquid
chromatography-quadrupole-time-of-flight mass
spectrometry. Analytical and Bioanalytical
Chemistry, 405(5), 1651-1661. <a
href="http://dx.doi.org/10.1007/s00216-012-656
2-x">[More Information]</a>
Merlot, A., Kalinowski, D., Richardson, D.
(2013). Novel Chelators for Cancer Treatment:
Where Are We Now? Antioxidants & Redox
Signaling, 18(8), 973-1006. <a
href="http://dx.doi.org/10.1089/ars.2012.4540">
[More Information]</a>
Lukmantara, A., Kalinowski, D., Kumar, N.,
Richardson, D. (2013). Structure-activity studies
of 4-phenyl-substituted 2'-benzoylpyridine
thiosemicarbazones with potent and selective
anti-tumour activity. Organic and Biomolecular
Chemistry, 11(37), 6414-6425. <a
href="http://dx.doi.org/10.1039/c3ob41109e">[
More Information]</a>
Lukmantara, A., Kalinowski, D., Kumar, N.,
Richardson, D. (2013). Synthesis and biological
evaluation of substituted 2-benzoylpyridine
thiosemicarbazones: Novel structure-activity
relationships underpinning their anti-proliferative
and chelation efficacy. Bioorganic & Medicinal
Chemistry Letters, 23(4), 967-974. <a
href="http://dx.doi.org/10.1016/j.bmcl.2012.12.0
44">[More Information]</a>
Lui, G., Obeidy, P., Ford, S., Tselepis, C., Sharp,
D., Jansson, P., Kalinowski, D., Kovacevic, Z.,
Lovejoy, D., Richardson, D. (2013). The Iron
Chelator, Deferasirox, as a Novel Strategy for
Cancer Treatment: Oral Activity Against Human
Lung Tumor Xenografts and Molecular
Mechanism of Action. Molecular Pharmacology,
83(1), 179-190. <a
href="http://dx.doi.org/10.1124/mol.112.081893
">[More Information]</a>
Kalinowski, D., Jansson, P., Kovacevic, Z.,
Richardson, D. (2013). The redox-active,
anti-cancer drug Dp44mT inhibits T-cell
activation and CD25 through a copper-dependent
mechanism. Redox Report, 18(2), 48-50. <a
href="http://dx.doi.org/10.1179/1351000213Y.0
000000041">[More Information]</a>
Bae, D., Jansson, P., Huang, M., Kovacevic, Z.,
Kalinowski, D., Lee, C., Sahni, S., Richardson,
D. (2013). The role of NDRG1 in the pathology
and potential treatment of human cancers.
Journal of Clinical Pathology, 66(11), 911-917.
<a
href="http://dx.doi.org/10.1136/jclinpath-2013-2
01692">[More Information]</a>
2012
Debebe, Z., Nekhai, S., Ashenafi, M., Lovejoy,
D., Kalinowski, D., Gordeuk, V., Byrnes, W.,
Richardson, D., Karla, P. (2012). Development
of a sensitive HPLC method to measure in vitro
permeability of E- and Z-isomeric forms of
thiosemicarbazones in Caco-2 monolayers.
Journal of Chromatography. B, Analytical
Technologies in the Biomedical and Life
Sciences, 906, 25-32. <a
href="http://dx.doi.org/10.1016/j.jchromb.2012.0
8.011">[More Information]</a>
Basha, M., Chartres, J., Pantarat, N., Akbar Ali,
M., Mirza, A., Kalinowski, D., Richardson, D.,
Bernhardt, P. (2012). Heterocyclic
dithiocarbazate iron chelators: Fe coordination
chemistry and biological activity. Dalton
Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 41(21), 6536-6548. <a
href="http://dx.doi.org/10.1039/c2dt12387h">[M
ore Information]</a>
Brychtova, K., Dvorakova, L., Opatrilova, R.,
Raich, I., Kacerova, S., Placek, L., Kalinowski,
D., Richardson, D., Jampilek, J. (2012).
Investigation of substituted 6-aminohexanoates
as skin penetration enhancers. Bioorganic and
Medicinal Chemistry, 20(1), 86-95. <a
href="http://dx.doi.org/10.1016/j.bmc.2011.11.0
33">[More Information]</a>
Stariat, J., Sestak, V., Vavrova, K., Nobilis, M.,
Kollarova, Z., Klimes, J., Kalinowski, D.,
Richardson, D., Kovarikova, P. (2012).
LC-MS/MS identification of the principal in
vitro and in vivo phase I metabolites of the novel
thiosemicarbazone anti-cancer drug, Bp4eT.
Analytical and Bioanalytical Chemistry, 403(1),
309-321. <a
href="http://dx.doi.org/10.1007/s00216-012-576
6-4">[More Information]</a>
Publications for Danuta Kalinowski
Quach, P., Gutierrez, E., Basha, M., Kalinowski,
D., Sharpe, P., Lovejoy, D., Bernhardt, P.,
Jansson, P., Richardson, D. (2012).
Methemoglobin Formation by Triapine,
Di-2-pyridylketone-4,4-dimethyl-3thiosemicarbazone (Dp44mT), and Other
Anticancer Thiosemicarbazones: Identification
of Novel Thiosemicarbazones and Therapeutics
That Prevent This Effect. Molecular
Pharmacology, 82(1), 105-114. <a
href="http://dx.doi.org/10.1124/mol.112.078964
">[More Information]</a>
Lok, H., Suryo Rahmanto, Y., Hawkins, C.,
Kalinowski, D., Morrow, C., Townsend, A.,
Ponka, P., Richardson, D. (2012). Nitric oxide
storage and transport in cells are mediated by
glutathione S-transferase P1-1 and Multidrug
Resistant Protein 1 via Dinitrosyl iron
complexes. Journal of Biological Chemistry,
287(1), 607-618. <a
href="http://dx.doi.org/10.1074/jbc.M111.31098
7">[More Information]</a>
Suryo Rahmanto, Y., Kalinowski, D., Lane, D.,
Lok, H., Richardson, V., Richardson, D. (2012).
Nitrogen Monoxide (NO) Storage and Transport
by Dinitrosyl-Dithiol-Iron Complexes:
Long-Lived NO that is Trafficked by Interacting
Proteins. Journal of Biological Chemistry,
287(10), 6960-6968. <a
href="http://dx.doi.org/10.1074/jbc.R111.329847
">[More Information]</a>
Lovejoy, D., Sharp, D., Seebacher, N., Obeidy,
P., Prichard, T., Stefani, C., Basha, M., Sharpe,
P., Jansson, P., Kalinowski, D., Richardson, D.,
et al (2012). Novel Second-Generation
Di-2-Pyridylketone Thiosemicarbazones Show
Synergism with Standard Chemotherapeutics and
Demonstrate Potent Activity against Lung
Cancer Xenografts after Oral and Intravenous
Administration in Vivo. Journal of Medicinal
Chemistry, 55(16), 7230-7244. <a
href="http://dx.doi.org/10.1021/jm300768u">[M
ore Information]</a>
Serda, M., Kalinowski, D.,
Mrozek-Wilczkiewicz, A., Musiol, R., Szurko,
A., Ratuszna, A., Pantarat, N., Kovacevic, Z.,
Merlot, A., Richardson, D., et al (2012).
Synthesis and characterization of
quinoline-based thiosemicarbazones and
correlation of cellular iron-binding efficacy to
anti-tumor efficacy. Bioorganic & Medicinal
Chemistry Letters, 22(17), 5527-5531. <a
href="http://dx.doi.org/10.1016/j.bmcl.2012.07.0
30">[More Information]</a>
2011
Stefani, C., Punnia-Moorthy, G., Lovejoy, D.,
Jansson, P., Kalinowski, D., Sharpe, P.,
Bernhardt, P., Richardson, D. (2011).
Halogenated 2'-Benzoylpyridine
Thiosemicarbazone (XBpT) Chelators with
Potent and Selective Anti-Neoplastic Activity:
Relationship to Intracellular Redox Activity.
Journal of Medicinal Chemistry, 54(19),
6936-6948. <a
href="http://dx.doi.org/10.1021/jm200924c">[M
ore Information]</a>
Debebe, Z., Ammosova, T., Breuer, D., Lovejoy,
D., Kalinowski, D., Karla, P., Kumar, K.,
Jarebtsova, M., Ray, P., Kashanchi, F.,
Richardson, D., et al (2011). Iron Chelators of
the Di-2-pyridylketone Thiosemicarbazone and
2-Benzoylpyridine Thiosemicarbazone Series
Inhibit HIV-1 Transcription: Identification of
Novel Cellular Targets-Iron, Cyclin-Dependent
Kinase (CDK) 2, and CDK9. Molecular
Pharmacology, 79(1), 185-196. <a
href="http://dx.doi.org/10.1124/mol.110.069062
">[More Information]</a>
Sharpe, P., Richardson, D., Kalinowski, D.,
Bernhardt, P. (2011). Synthetic and natural
products as iron chelators. Current Topics in
Medicinal Chemistry, 11(5), 591-607. <a
href="http://dx.doi.org/10.2174/1568026117947
85163">[More Information]</a>
Kovacevic, Z., Kalinowski, D., Lovejoy, D., Yu,
Y., Suryo Rahmanto, Y., Sharpe, P., Bernhardt,
P., Richardson, D. (2011). The Medicinal
Chemistry of Novel Iron Chelators for the
Treatment of Cancer. Current Topics in
Medicinal Chemistry, 11(5), 483-499. <a
href="http://dx.doi.org/10.2174/1568026117947
85190">[More Information]</a>
2010
Miao, Q., Xu, D., Wang, Z., Xu, L., Wang, T.,
Wu, Y., Lovejoy, D., Kalinowski, D.,
Richardson, D., Nie, G., et al (2010).
Amphiphilic hyper-branched co-polymer
nanoparticles for the controlled delivery of
anti-tumor agents. Biomaterials, 31(28),
7364-7375. <a
href="http://dx.doi.org/10.1016/j.biomaterials.20
10.06.012">[More Information]</a>
Bendova, P., Mackova, E., Haskova, P.,
Vavrova, A., Jirkovsky, E., Sterba, M., Popelova,
O., Kalinowski, D., Kovarikova, P., Vavrova, K.,
Richardson, D., et al (2010). Comparison of
Clinically Used and Experimental Iron Chelators
for Protection against Oxidative Stress-Induced
Cellular Injury. Chemical Research in
Toxicology, 23(6), 1105-1114. <a
href="http://dx.doi.org/10.1021/tx100125t">[Mo
re Information]</a>
Liu, J., Obando Gutierrez, D., Schipanski, L.,
Groebler, L., Witting, P., Kalinowski, D.,
Richardson, D., Codd, R. (2010). Conjugates of
Desferrioxamine B (DFOB) with Derivatives of
Publications for Danuta Kalinowski
Adamantane or with Orally Available Chelators
as Potential Agents for Treating Iron Overload.
Journal of Medicinal Chemistry, 53(3),
1370-1382. <a
href="http://dx.doi.org/10.1021/jm9016703">[M
ore Information]</a>
Stariat, J., Kovarikova, P., Klimes, J.,
Kalinowski, D., Richardson, D. (2010).
Development of an LC-MS/MS method for
analysis of interconvertible Z/E isomers of the
novel anticancer agent, Bp4eT. Analytical and
Bioanalytical Chemistry, 397(1), 161-171. <a
href="http://dx.doi.org/10.1007/s00216-009-344
8-7">[More Information]</a>
Brychtova, K., Opatrilova, R., Raich, I.,
Kalinowski, D., Dvorakova, L., Placek, L.,
Csollei, J., Richardson, D., Jampilek, J. (2010).
Investigating the activity of 2-substituted
alkyl-6-(25-dioxopyrrolidin-1-yl)hexanoates as
skin penetration enhancers. Bioorganic and
Medicinal Chemistry, 18(24), 8556-8565. <a
href="http://dx.doi.org/10.1016/j.bmc.2010.10.0
25">[More Information]</a>
Mrozek-Wilczkiewicz, A., Kalinowski, D.,
Musiol, R., Finster, J., Szurko, A., Serafin, K.,
Knas, M., Kamalapuram, S., Kovacevic, Z.,
Jampilek, J., Richardson, D., et al (2010).
Investigating the anti-proliferative activity of
styrylazanaphthalenes and azanaphthalenediones.
Bioorganic and Medicinal Chemistry, 18(7),
2664-2671. <a
href="http://dx.doi.org/10.1016/j.bmc.2010.02.0
25">[More Information]</a>
Otevrel, J., Mandelova, Z., Pesko, M., Guo, J.,
Kralova, K., Sersen, F., Vejsova, M.,
Kalinowski, D., Kovacevic, Z., Coffey, A.,
Richardson, D., et al (2010). Investigating the
Spectrum of Biological Activity of
Ring-Substituted Salicylanilides and
Carbamoylphenylcarbamates. Molecules, 15(11),
8122-8142. <a
href="http://dx.doi.org/10.3390/molecules15118
122">[More Information]</a>
Kovacevic, Z., Kalinowski, D., Lovejoy, D.,
Quach, P., Burn (Wong), J., Richardson, D.
(2010). Iron Chelators: Development of Novel
Compounds with High and Selective
Anti-Tumour Activity. Current Drug Delivery,
7(3), 194-207. <a
href="http://dx.doi.org/10.2174/1567201107915
60991">[More Information]</a>
Merlot, A., Pantarat, N., Lovejoy, D.,
Kalinowski, D., Richardson, D. (2010).
Membrane Transport and Intracellular
Sequestration of Novel Thiosemicarbazone
Chelators for the Treatment of Cancer.
Molecular Pharmacology, 78(4), 675-684. <a
href="http://dx.doi.org/10.1124/mol.110.066126
">[More Information]</a>
2009
Richardson, D., Kalinowski, D., Richardson, V.,
Sharpe, P., Lovejoy, D., Islam, M., Bernhardt, P.
(2009). 2-Acetylpyridine Thiosemicarbazones
are Potent Iron Chelators and Antiproliferative
Agents: Redox Activity, Iron Complexation and
Characterization of their Antitumor Activity.
Journal of Medicinal Chemistry, 52(5),
1459-1470. <a
href="http://dx.doi.org/10.1021/jm801585u">[M
ore Information]</a>
Noulsri, E., Richardson, D., Lerdwana, S.,
Fucharoen, S., Yamagishi, T., Kalinowski, D.,
Pattanapanyasat, K. (2009). Antitumor activity
and mechanism of action of the iron chelator,
Dp44mT, against leukemic cells. American
Journal Of Hematology, 84(3), 170-176. <a
href="http://dx.doi.org/10.1002/ajh.21350">[Mo
re Information]</a>
Richardson, D., Kalinowski, D., Lau, S., Jansson,
P., Lovejoy, D. (2009). Cancer cell iron
metabolism and the development of potent iron
chelators as anti-tumour agents. Biochimica et
Biophysica Acta, 1790 (7), 702-717. <a
href="http://dx.doi.org/10.1016/j.bbagen.2008.04
.003">[More Information]</a>
Stariat, J., Kovarikova, P., Klimes, J., Lovejoy,
D., Kalinowski, D., Richardson, D. (2009).
HPLC methods for determination of two novel
thiosemicarbazone anti-cancer drugs (N4mT and
Dp44mT) in plasma and their application to in
vitro plasma stability of these agents. Journal of
Chromatography. B, Analytical Technologies in
the Biomedical and Life Sciences, 877(3),
316-322. <a
href="http://dx.doi.org/10.1016/j.jchromb.2008.1
1.044">[More Information]</a>
Bernhardt, P., Sharpe, P., Islam, M., Lovejoy, D.,
Kalinowski, D., Richardson, D. (2009). Iron
Chelators of the Dipyridylketone
Thiosemicarbazone Class: Precomplexation and
Transmetalation Effects on Anticancer Activity.
Journal of Medicinal Chemistry, 52(2), 407-415.
<a
href="http://dx.doi.org/10.1021/jm801012z">[M
ore Information]</a>
Mladenka, P., Kalinowski, D., Haskova, P.,
Bobrovova, Z., Hrdina, R., Simunek, T.,
Nachtigal, P., Semecky, V., Vavrova, J.,
Holeckova, M., Jansson, P., Richardson, D., et al
(2009). The Novel Iron Chelator,
2-Pyridylcarboxaldehyde 2-Thiophenecarboxyl
Hydrazone, Reduces Catecholamine-Mediated
Myocardial Toxicity. Chemical Research in
Toxicology, 22(1), 208-217. <a
href="http://dx.doi.org/10.1021/tx800331j">[Mo
re Information]</a>
Publications for Danuta Kalinowski
Yu, Y., Kalinowski, D., Kovacevic, Z., Siafakas,
A., Jansson, P., Stefani, C., Lovejoy, D., Sharpe,
P., Bernhardt, P., Richardson, D. (2009).
Thiosemicarbazones from the Old to New: Iron
Chelators That Are More Than Just
Ribonucleotide Reductase Inhibitors. Journal of
Medicinal Chemistry, 52(17), 5271-5294. <a
href="http://dx.doi.org/10.1021/jm900552r">[M
ore Information]</a>
Kalinowski, D., Quach, P., Richardson, D.
(2009). Thiosemicarbazones: the new wave in
cancer treatment. Future Medicinal Chemistry,
1(6), 1143-1151. <a
href="http://dx.doi.org/10.4155/fmc.09.80">[Mo
re Information]</a>
2008
Kalinowski, D., Richardson, D. (2008). Cellular
and Molecular Biology of Iron-Binding Proteins.
In Rudolfs K. Zalups, D. James Koropatnick
(Eds.), Cellular and Molecular Biology of
Metals.
Opletalova, V., Kalinowski, D., Vesjova, M.,
Kunes, J., Pour, M., Jampılek, J., Buchta, V.,
Richardson, D. (2008). Identification and
Characterization of Thiosemicarbazones with
Antifungal and Antitumor Effects: Cellular Iron
Chelation Mediating Cytotoxic Activity.
Chemical Research in Toxicology, 21(9),
1878-1889. <a
href="http://dx.doi.org/10.1021/tx800182k">[M
ore Information]</a>
Lim, C., Kalinowski, D., Richardson, D. (2008).
Protection Against Hydrogen Peroxide-Mediated
Cytotoxicity in Friedreich's Ataxia Fibroblasts
using Novel Iron Chelators of the
2-Pyridylcarboxaldehyde Isonicotinoyl
Hydrazone Class. Molecular Pharmacology,
74(1), 225-235. <a
href="http://dx.doi.org/10.1124/mol.108.046847
">[More Information]</a>
Kalinowski, D., Sharpe, P., Bernhardt, P.,
Richardson, D. (2008). Structure-activity
relationships of novel iron chelators for the
treatment of iron overload disease: the methyl
pyrazinylketone isonicotinoyl hydrazone series.
Journal of Medicinal Chemistry, 51(2), 331-344.
<a
href="http://dx.doi.org/10.1021/jm7012562">[M
ore Information]</a>
Bernhardt, P., Wilson, G., Sharpe, P.,
Kalinowski, D., Richardson, D. (2008). Tuning
the antiproliferative activity of biologically
active iron chelators: characterization of the
coordination chemistry and biological efficacy of
2-acetylpyridine and 2-benzoylpyridine
hydrazone ligands. Journal of Biological
Inorganic Chemistry, 13(1), 107-119. <a
href="http://dx.doi.org/10.1007/s00775-007-030
0-4">[More Information]</a>
2007
Kalinowski, D., Sharpe, P., Bernhardt, P.,
Richardson, D. (2007). Design, Synthesis, and
Characterization of New Iron Chelators with
Anti-Proliferative Activity: Structure-Activity
Relationships of Novel Thiohydrazone
Analogues. Journal of Medicinal Chemistry,
50(24), 6212-6225. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17963372">[More Information]</a>
Kalinowski, D., Yu, Y., Sharpe, P., Islam, M.,
Liao, Y., Lovejoy, D., Kumar, N., Bernhardt, P.,
Richardson, D. (2007). Design, Synthesis, and
Characterization of Novel Iron Chelators:
Structure-Activity Relationships of the
2-Benzoylpyridine Thiosemicarbazone Series
and Their 3-Nitrobenzoyl Analogues as Potent
Antitumor Agents. Journal of Medicinal
Chemistry, 50(15), 3716-3729. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17602603">[More Information]</a>
Mrkvicková, Z., Kovaríková, P., Klimes, J.,
Kalinowski, D., Richardson, D. (2007).
Development and validation of HPLC-DAD
methods for the analysis of two novel iron
chelators with potent anti-cancer activity.
Journal of Pharmaceutical and Biomedical
Analysis, 43(4), 1343-1351. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17166684">[More Information]</a>
Kalinowski, D., Richardson, D. (2007). Future of
toxicology--iron chelators and differing modes of
action and toxicity: the changing face of iron
chelation therapy. Chemical Research in
Toxicology, 20(5), 715-720. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17402750">[More Information]</a>
Musiol, R., Jampilek, J., Kralova, K.,
Richardson, D., Kalinowski, D., Podeszwa, B.,
Finster, J., Niedbala, H., Palka, A., Polanski, J.
(2007). Investigating biological activity spectrum
for novel quinoline analogues. Bioorganic and
Medicinal Chemistry, 15(3), 1280-1288. <a
href="http://dx.doi.org/10.1016/j.bmc.2006.11.0
20">[More Information]</a>
Podeszwa, B., Niedbala, H., Polanski, J., Musiol,
R., Tabak, D., Finster, J., Serafin, K., Milczarek,
M., Wietrzyk, J., Boryczka, S., Kalinowski, D.,
Richardson, D., et al (2007). Investigating the
antiproliferative activity of quinoline-5,8-diones
and styrylquinolinecarboxylic acids on tumor
cell lines. Bioorganic and Medicinal Chemistry
Letters: the tetrahedron journal for research at
Publications for Danuta Kalinowski
the interface of chemistry and biology, 17(22),
6138-6141. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17904844">[More Information]</a>
Podeszwa, B., Niedbala, H., Polanski, J., Musiol,
R., Tabak, D., Finster, J., Serafin, K., Milczarek,
M., Wietrzyk, J., Boryczka, S., Kalinowski, D.,
Richardson, D., et al (2007). Investigating the
antiproliferative and styrylquinolinecarboxyli
activity of quinoline-5,8-diones and
styrylquinolinecarboxylic acids on tumor cell
lines. Bioorganic and Medicinal Chemistry
Letters: the tetrahedron journal for research at
the interface of chemistry and biology, 17(22),
6138-6141. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17904844">[More Information]</a>
Mizdrak, J., Hains, P., Kalinowski, D., Truscott,
R., Davies, M., Jamie, J. (2007). Novel human
lens metabolites from normal and cataractous
human lenses. Tetrahedron, 63(23), 4990-4999.
2006
Yu, Y., Wong, J., Lovejoy, D., Kalinowski, D.,
Richardson, D. (2006). Chelators at the cancer
coalface: desferrioxamine to triapine and beyond.
Clinical Cancer Research, 12(23), 6876-6883.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17145804">[More Information]</a>
Richardson, D., Sharpe, P., Lovejoy, D.,
Senaratne, D., Kalinowski, D., Islam, M.,
Bernhardt, P. (2006). Dipyridyl
Thiosemicarbazone Chelators with Potent and
Selective Antitumor Activity Form Iron
Complexes with Redox Activity. Journal of
Medicinal Chemistry, 49(22), 6510-6521. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17064069">[More Information]</a>
Lovejoy, D., Kalinowski, D., Bernhardt, P.,
Richardson, D. (2006). PCTH: A Novel Orally
Active Chelator for the Treatment of Iron
Overload Disease. Hemoglobin, 30(1), 93-104.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16540421">[More Information]</a>
2005
Kalinowski, D., Richardson, D. (2005). The
Evolution of Iron Chelators for the Treatment of
Iron Overload Disease and Cancer.
Pharmacological Reviews, 57(4), 547-583. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16382108">[More Information]</a>