Publications for Clare Hawkins
Publications for Clare Hawkins
2016
Galougahi, K., Liu, C., Garcia, A., Gentile, C.,
Fry, N., Hamilton, E., Hawkins, C., Figtree, G.
(2016). Beta3 adrenergic stimulation restores
nitric oxide/redox balance and enhances
endothelial function in hyperglycemia. Journal
of the American Heart Association, 5, 1-17. <a
href="http://dx.doi.org/10.1161/JAHA.115.0028
24">[More Information]</a>
Love, D., Barrett, T., White, M., Cordwell, S.,
Davies, M., Hawkins, C. (2016). Cellular targets
of the myeloperoxidase-derived oxidant
hypothiocyanous acid (HOSCN) and its role in
the inhibition of glycolysis in macrophages. Free
Radical Biology and Medicine, 94, 88-98. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2016.02.016">[More Information]</a>
Majima, H., Indo, H., Nakanishi, I., Suenaga, S.,
Matsumoto, K., Matsui, H., Minamiyama, Y.,
Ichikawa, H., Hawkins, C., Davies, M., et al
(2016). Chasing great paths of Helmut Sies
"Oxidative Stress". Archives of Biochemistry and
Biophysics, 595, 54-60. <a
href="http://dx.doi.org/10.1016/j.abb.2015.10.02
3">[More Information]</a>
2015
Boon, A., Hawkins, C., Coombes, J., Wagner,
K., Bulmer, A. (2015). Bilirubin scavenges
chloramines and inhibits myeloperoxidase
induced protein/lipid oxidation in physiologically
relevant hyperbilirubinaemic serum. Free
Radical Biology and Medicine, 86, 259-268. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2015.05.031">[More Information]</a>
Ismael, F., Proudfoot, J., Brown, B., van Reyk,
D., Croft, K., Davies, M., Hawkins, C. (2015).
Comparative reactivity of the
myeloperoxidase-derived oxidants HOCl and
HOSCN with low-density lipoprotein (LDL):
Implications for foam cell formation in
atherosclerosis. Archives of Biochemistry and
Biophysics, 573, 40-51. <a
href="http://dx.doi.org/10.1016/j.abb.2015.03.00
8">[More Information]</a>
Indo, H., Matsui, H., Chen, J., Zhu, H., Hawkins,
C., Davies, M., Yarana, C., St Clair, D., Majima,
H. (2015). Manganese superoxide dismutase
promotes interaction of actin, S100A4 and Talin,
and enhances rat gastric tumor cell invasion.
Journal of Clinical Biochemistry and Nutrition,
57(1), 13-20. <a
href="http://dx.doi.org/10.3164/jcbn.14-146">[
More Information]</a>
Carroll, L., Pattison, D., Fu, S., Schiesser, C.,
Davies, M., Hawkins, C. (2015). Reactivity of
selenium-containing compounds with
myeloperoxidase-derived chlorinating oxidants:
Second-order rate constants and implications for
biological damage. Free Radical Biology and
Medicine, 84, 279-288. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2015.03.029">[More Information]</a>
Hawkins, C., Van Antwerpen, P. (2015). Special
issue on "Peroxidase". Free Radical Research,
49(6), 693-694. <a
href="http://dx.doi.org/10.3109/10715762.2015.
1038259">[More Information]</a>
2014
Rayner, B., Love, D., Hawkins, C. (2014).
Comparative reactivity of
myeloperoxidase-derived oxidants with
mammalian cells. Free Radical Biology and
Medicine, 71, 240-255. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2014.03.004">[More Information]</a>
Hawkins, C., Davies, M. (2014). Detection and
characterisation of radicals in biological
materials using EPR methodology. Biochimica et
Biophysica Acta. Molecular and Cell Biology of
Lipids, 1840 (2), 708-721. <a
href="http://dx.doi.org/10.1016/j.bbagen.2013.03
.034">[More Information]</a>
Galougahi, K., Liu, C., Gentile, C., Kok, C.,
Nunez, A., Garcia, A., Fry, N., Davies, M.,
Hawkins, C., Rasmussen, H., Figtree, G. (2014).
Glutathionylation Mediates Angiotension
II-Induced eNOS Uncoupling, Amplifying
NADPH Oxidase-Dependent Endothelial
Dysfunction. Journal of the American Heart
Association, 3(2), 1-11. <a
href="http://dx.doi.org/10.1161/JAHA.113.0007
31">[More Information]</a>
Kajer, T., Fairfull-Smith, K., Yamasaki, T.,
Yamada, K., Fu, S., Bottle, S., Hawkins, C.,
Davies, M. (2014). Inhibition of
myeloperoxidase- and neutrophil-mediated
oxidant production by tetraethyl and tetramethyl
nitroxides. Free Radical Biology and Medicine,
70, 96-105. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2014.02.011">[More Information]</a>
Hawkins, C. (2014). Role of cyanate in the
induction of vascular dysfunction during uremia:
More than protein carbamylation? Kidney
International, 86(5), 875-877. <a
href="http://dx.doi.org/10.1038/ki.2014.256">[
More Information]</a>
Bonifay, V., Barrett, T., Pattison, D., Davies, M.,
Hawkins, C., Ashby, M. (2014). Tryptophan
oxidation in proteins exposed to
thiocyanate-derived oxidants. Archives of
Biochemistry and Biophysics, 564, 1-11. <a
Publications for Clare Hawkins
href="http://dx.doi.org/10.1016/j.abb.2014.08.01
4">[More Information]</a>
2013
Lloyd, M., Grima, M., Rayner, B., Hadfield, K.,
Davies, M., Hawkins, C. (2013). Comparative
reactivity of the myeloperoxidase-derived
oxidants hypochlorous acid and hypothiocyanous
acid with human coronary artery endothelial
cells. Free Radical Biology and Medicine, 65,
1352-1362. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2013.10.007">[More Information]</a>
Hadfield, K., Pattison, D., Brown, B., Hou, L.,
Rye, K., Davies, M., Hawkins, C. (2013).
Myeloperoxidase-derived oxidants modify
apolipoprotein A-I and generate dysfunctional
high-density lipoproteins: comparison of
hypothiocyanous acid (HOSCN) with
hypochlorous acid (HOCI). The Biochemical
Journal, 449(2), 531-542. <a
href="http://dx.doi.org/10.1042/BJ20121210">[
More Information]</a>
2012
Barrett, T., Hawkins, C. (2012).
Hypothiocyanous Acid: Benign or Deadly?
Chemical Research in Toxicology, 25(2),
263-273. <a
href="http://dx.doi.org/10.1021/tx200219s">[Mo
re Information]</a>
Summers, F., Forsman Quigley, A., Hawkins, C.
(2012). Identification of proteins susceptible to
thiol oxidation in endothelial cells exposed to
hypochlorous acid and N-chloramines.
Biochemical and Biophysical Research
Communications, 425(2), 157-161. <a
href="http://dx.doi.org/10.1016/j.bbrc.2012.07.0
57">[More Information]</a>
Barrett, T., Pattison, D., Leonard, S., Carroll, K.,
Davies, M., Hawkins, C. (2012). Inactivation of
thiol-dependent enzymes by hypothiocyanous
acid: role of sulfenyl thiocyanate and sulfenic
acid intermediates. Free Radical Biology and
Medicine, 52(6), 1075-1085. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2011.12.024">[More Information]</a>
Lok, H., Suryo Rahmanto, Y., Hawkins, C.,
Kalinowski, D., Morrow, C., Townsend, A.,
Ponka, P., Richardson, D. (2012). Nitric oxide
storage and transport in cells are mediated by
glutathione S-transferase P1-1 and Multidrug
Resistant Protein 1 via Dinitrosyl iron
complexes. Journal of Biological Chemistry,
287(1), 607-618. <a
href="http://dx.doi.org/10.1074/jbc.M111.31098
7">[More Information]</a>
Pattison, D., Davies, M., Hawkins, C. (2012).
Reactions and reactivity of
myeloperoxidase-derived oxidants: Differential
biological effects of hypochlorous and
hypothiocyanous acids. Free Radical Research,
46(8), 975-995. <a
href="http://dx.doi.org/10.3109/10715762.2012.
667566">[More Information]</a>
Boon, A., Hawkins, C., Bisht, K., Coombes, J.,
Bakrania, B., Wagner, K., Bulmer, A. (2012).
Reduced circulating oxidized LDL is associated
with hypocholesterolemia and enhanced thiol
status in Gilbert syndrome. Free Radical Biology
and Medicine, 52(10), 2120-2127. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2012.03.002">[More Information]</a>
2011
Gracanin, M., Lam, M., Morgan, P., Rodgers, K.,
Hawkins, C., Davies, M. (2011). Amino acid,
peptide, and protein hydroperoxides and their
decomposition products modify the activity of
the 26S proteasome. Free Radical Biology and
Medicine, 50(2), 389-399. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2010.11.019">[More Information]</a>
Morgan, P., Pattison, D., Talib, J., Summers, F.,
Harmer, J., Celermajer, D., Hawkins, C., Davies,
M. (2011). High plasma thiocyanate levels in
smokers are a key determinant of thiol oxidation
induced by myeloperoxidase. Free Radical
Biology and Medicine, 51(9), 1815-1822. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2011.08.008">[More Information]</a>
Yu, Y., Suryo Rahmanto, Y., Hawkins, C.,
Richardson, D. (2011). The Potent and Novel
Thiosemicarbazone Chelators Di-2pyridylketone-4,4-dimethyl-3-thiosemicarbazone
and 2Benzoylpyridine-4,4-dimethyl-3-thiosemicarbaz
one Affect
Crucial Thiol Systems Required for
Ribonucleotide Reductase Activity. Molecular
Pharmacology, 79(6), 921-931. <a
href="http://dx.doi.org/10.1124/mol.111.071324
">[More Information]</a>
2010
Stanley, N., Pattison, D., Hawkins, C. (2010).
Ability of Hypochlorous Acid and
N-Chloramines to Chlorinate DNA and Its
Constituents. Chemical Research in Toxicology,
23(7), 1293-1302. <a
href="http://dx.doi.org/10.1021/tx100188b">[M
ore Information]</a>
Koelsch, M., Mallak, R., Graham, G., Kajer, T.,
Milligan, M., Nguyen, L., Newsham, D., Keh, J.,
Kettle, A., Scott, K., Pattison, D., Hawkins, C.,
Davies, M., et al (2010). Acetaminophen
(paracetamol) inhibits
myeloperoxidase-catalyzed oxidant production
Publications for Clare Hawkins
and biological damage at therapeutically
achievable concentrations. Biochemical
Pharmacology, 79(8), 1156-1164. <a
href="http://dx.doi.org/10.1016/j.bcp.2009.11.02
4">[More Information]</a>
Suryo Rahmanto, A., Morgan, P., Hawkins, C.,
Davies, M. (2010). Cellular effects of peptide
and protein hydroperoxides. Free Radical
Biology and Medicine, 48(8), 1071-1078. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2010.01.025">[More Information]</a>
Rahmanto, A., Morgan, P., Hawkins, C., Davies,
M. (2010). Cellular effects of photo-generated
oxidants and long-lived, reactive, hydroperoxide
photoproducts. Free Radical Biology and
Medicine, 49(10), 1505-1515. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2010.08.006">[More Information]</a>
Jansson, P., Hawkins, C., Lovejoy, D.,
Richardson, D. (2010). The iron complex of
Dp44mT is redox-active and induces hydroxyl
radical formation: An EPR study. Journal of
Inorganic Biochemistry, 104(11), 1224-1228. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2010.
07.012">[More Information]</a>
Lane, A., Tan, J., Hawkins, C., Heather, A.,
Davies, M. (2010). The myeloperoxidase-derived
oxidant HOSCN inhibits protein tyrosine
phosphatases and modulates cell signalling via
the mitogen-activated protein kinase (MAPK)
pathway in macrophages. Biochemical Journal,
430(1), 161-169. <a
href="http://dx.doi.org/10.1042/BJ20100082">[
More Information]</a>
2009
Hawkins, C., Morgan, P., Davies, M. (2009).
Quantification of protein modification by
oxidants. Free Radical Biology and Medicine,
46(8), 965-988. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2009.01.007">[More Information]</a>
Gracanin, M., Hawkins, C., Pattison, D., Davies,
M. (2009). Singlet-oxygen-mediated amino acid
and protein oxidation: formation of tryptophan
peroxides and decomposition products. Free
Radical Biology and Medicine, 47(1), 92-102. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2009.04.015">[More Information]</a>
Hawkins, C. (2009). The role of
hypothiocyanous acid (HOSCN) in biological
systems. Free Radical Research, 43(12),
1147-1158. <a
href="http://dx.doi.org/10.3109/1071576090321
4462">[More Information]</a>
Pattison, D., Hawkins, C., Davies, M. (2009).
What are the plasma targets of the oxidant
hypochlorous acid? A kinetic modeling
approach. Chemical Research in Toxicology,
22(5), 807-817. <a
href="http://dx.doi.org/10.1021/tx800372d">[M
ore Information]</a>
2008
Szuchman-Sapir, A., Pattison, D., Ellis, N.,
Hawkins, C., Davies, M., Witting, P. (2008).
Hypochlorous acid oxidizes methionine and
tryptophan residues in myoglobin. Free Radical
Biology and Medicine, 45(6), 789-798. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2008.06.010">[More Information]</a>
Lloyd, M., van Reyk, D., Davies, M., Hawkins,
C. (2008). Hypothiocyanous acid is a more
potent inducer of apoptosis and protein thiol
depletion in murine macrophage cells than
hypochlorous acid or hypobromous acid.
Biochemical Journal, 414(2), 271-280. <a
href="http://dx.doi.org/10.1042/BJ20080468">[
More Information]</a>
Summers, F., Morgan, P., Davies, M., Hawkins,
C. (2008). Identification of plasma proteins that
are susceptible to thiol oxidation by
hypochlorous acid and N-chloramines. Chemical
Research in Toxicology, 21(9), 1832-1840. <a
href="http://dx.doi.org/10.1021/tx8001719">[M
ore Information]</a>
Davies, M., Hawkins, C., Pattison, D., Rees, M.
(2008). Mammalian heme peroxidases: from
molecular mechanisms to health implications.
Antioxidants & Redox Signaling, 10(7),
1199-1234. <a
href="http://dx.doi.org/10.1089/ars.2007.1927">
[More Information]</a>
Morgan, P., Pattison, D., Hawkins, C., Davies,
M. (2008). Separation, detection, and
quantification of hydroperoxides formed at
side-chain and backbone sites on amino acids,
peptides, and proteins. Free Radical Biology and
Medicine, 45(9), 1279-1289. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2008.08.004">[More Information]</a>
Hawkins, C., Pattison, D., Stanley, N., Davies,
M. (2008). Tryptophan residues are targets in
hypothiocyanous acid-mediated protein
oxidation. Biochemical Journal, 416(3),
441-452. <a
href="http://dx.doi.org/10.1042/BJ20070941">[
More Information]</a>
2007
Hawkins, C., Pattison, D., Whiteman, M.,
Davies, M. (2007). Chlorination and nitration of
DNA and nucleic acid components. In Evans
M; Cooke M (Eds.), Oxidative Damage to
Nucleic Acids, (pp. 14-39). United States:
Springer.
Publications for Clare Hawkins
Pattison, D., Hawkins, C., Davies, M. (2007).
Hypochlorous Acid-Mediated Protein Oxidation:
How Important Are Chloramine Transfer
Reactions and Protein Tertiary Structure?
Biochemistry, 46(34), 9853-9864. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17676767">[More Information]</a>
2006
Agon, V., Bubb, W., Wright, A., Hawkins, C.,
Davies, M. (2006). Corrigendum to
“Sensitizer-mediated photo-oxidation of histidine
residues: Evidence for the formation of reactive
side-chain peroxides�? Free Radical Biology
and Medicine, 40(12), 2242-2242. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2006.03.012">[More Information]</a>
Watts, R., Hawkins, C., Ponka, P., Richardson,
D. (2006). Nitrogen monoxide (NO)-mediated
iron release from cells is linked to NO-induced
glutathione efflux via multidrug
resistance-associated protein 1. Proceedings of
the National Academy of Sciences of the United
States of America (PNAS), 103(20), 7670-7675.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16679408">[More Information]</a>
Agon, V., Bubb, W., Wright, A., Hawkins, C.,
Davies, M. (2006). Sensitizer-mediated
photooxidation of histidine residues: evidence
for the formation of reactive side-chain
peroxides. Free Radical Biology and Medicine,
40(4 to 5), 698-710. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2005.09.039">[More Information]</a>
2005
Hawkins, C., Davies, M. (2005). Inactivation of
protease inhibitors and lysozyme by
hypochlorous acid: role of side-chain oxidation
and protein unfolding in loss of biological
function. Chemical Research in Toxicology,
18(10), 1600-1610.
Hawkins, C., Davies, M. (2005). The Role of
Aromatic Amino Acid Oxidation, Protein
Unfolding, and Aggregation in the Hypobromous
Acid-Induced Inactivation of Trypsin Inhibitor
and Lysozyme. Chemical Research in
Toxicology, 18(11), 1669-1677. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16300375">[More Information]</a>
Hawkins, C., Davies, M. (2005). The role of
reactive N-bromo species and radical
intermediates in hypobromous acid-induced
protein oxidation. Free Radical Biology and
Medicine. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16140210">[More Information]</a>
2004
Davies, M., Hawkins, C. (2004). EPR spin
trapping of protein radicals. Free Radical
Biology and Medicine, 36(9), 1072-1086. <a
href="http://dx.doi.org/10.1016/j.freeradbiomed.
2003.12.013">[More Information]</a>
Rees, M., Hawkins, C., Davies, M. (2004).
Hypochlorite and superoxide radicals can act
synergistically to induce fragmentation of
hyaluronan and chondroitin sulphates.
Biochemical Journal, 381(1), 175-184.
2003
Hawkins, C., Pattison, D., Davies, M. (2003).
Hypochlorite-induced oxidation of amino acids,
peptides and proteins. Amino Acids, 25(3-4),
259-274. <a
href="http://dx.doi.org/10.1007/s00726-003-001
6-x">[More Information]</a>
Rees, M., Hawkins, C., Davies, M. (2003).
Hypochlorite-Mediated Fragmentation of
Hyaluronan, Chondroitin Sulfates, and Related
N-Acetyl Glycosamines: Evidence for
Chloramide Intermediates, Free Radical Transfer
Reactions, and Site-Specific Fragmentation.
Journal of the American Chemical Society,
125(45), 13719-13733.
Pattison, D., Hawkins, C., Davies, M. (2003).
Hypochlorous Acid-Mediated Oxidation of Lipid
Components and Antioxidants Present in LowDensity Lipoproteins: Absolute Rate Constants,
Product Analysis, and Computational Modeling.
Chemical Research in Toxicology, 16(4),
439-449.
Wright, A., Hawkins, C., Davies, M. (2003).
Photo-oxidation of cells generates long-lived
intracellular protein peroxides. Free Radical
Biology and Medicine, 34(6), 637-647.
2002
Hawkins, C., Pattison, D., Davies, M. (2002).
Reaction of protein chloramines with DNA and
nucleosides: evidence for the formation of
radicals, protein-DNA cross-links and DNA
fragmentation. Biochemical Journal, 365(3),
605-615.
Wright, A., Bubb, W., Hawkins, C., Davies, M.
(2002). Singlet oxygen-mediated protein
oxidation: evidence for the formation of reactive
side chain peroxides on tyrosine residues.
Photochemistry and Photobiology, 76(1), 35-46.
Hawkins, C., Rees, M., Davies, M. (2002).
Superoxide radicals can act synergistically with
Publications for Clare Hawkins
hypochlorite to induce damage to proteins. FEBS
Letters, 510(1-2), 41-44.
2001
Hawkins, C., Davies, M. (2001). Generation and
propagation of radical reactions on proteins.
Biochimica et Biophysica Acta, 1504 (2-3),
196-219.
Hawkins, C., Brown, B., Davies, M. (2001).
Hypochlorite- and hypobromite-mediated radical
formation and its role in cell lysis. Archives of
Biochemistry and Biophysics, 395, 137-145.
Hawkins, C., Davies, M. (2001).
Hypochlorite-induced damage to nucleosides:
formation of chloramines and nitrogen-centered
radicals. Chemical Research in Toxicology, 14,
1071-1081.
Carr, A., Hawkins, C., Thomas, S., Stocker, R.,
Frei, B. (2001). Relative reactivities of
N-chloramines and hypochlorous with human
plasma constitutes. Free Radical Biology and
Medicine, 30, 526-536.