Publications for Ian Alexander
Publications for Ian Alexander
2015
Gray, P., Logan, G., Alexander, I., Poulton, S.,
Roscioli, T., Ziegler, J. (2015). A novel intronic
splice site deletion of the IL-2 receptor common
gamma chain results in expression of a
dysfunctional protein and T-cell-positive
X-linked Severe combined immunodeficiency.
International Journal of Immunogenetics, 42(1),
11-14. <a
href="http://dx.doi.org/10.1111/iji.12166">[Mor
e Information]</a>
Mak, K., Chin, R., Cunningham, S., Habib, M.,
Torresi, J., Sharland, A., Alexander, I., Angus,
P., Herath, C. (2015). ACE2 Therapy Using
Adeno-associated Viral Vector Inhibits Liver
Fibrosis in Mice. Molecular Therapy, 23(9),
1434-1443. <a
href="http://dx.doi.org/10.1038/mt.2015.92">[M
ore Information]</a>
Lisowski, L., Tay, S., Alexander, I. (2015).
Adeno-associated virus serotypes for gene
therapeutics. Current Opinion in Pharmacology,
24, 59-67. <a
href="http://dx.doi.org/10.1016/j.coph.2015.07.0
06">[More Information]</a>
Hallwirth, C., Garg, G., Peters, T., Kramer, B.,
Malani, N., Hyman, J., Ruan, X., Ginn, S.,
Hetherington, N., Veeravalli, L., Liddle, C.,
Alexander, I., et al (2015). Coherence analysis
discriminates between retroviral integration
patterns in CD34(+) cells transduced under
differing clinical trial conditions. Molecular
Therapy - Methods & Clinical Development, 2,
1-10. <a
href="http://dx.doi.org/10.1038/mtm.2015.15">[
More Information]</a>
Menon, T., Firth, A., Scripture-Adams, D., Galic,
Z., Qualls, S., Gilmore, W., Ke, E., Singer, O.,
Anderson, L., Alexander, I., et al (2015).
Lymphoid Regeneration from Gene-Corrected
SCID-X1 Subject-Derived iPSCs. Cell Stem
Cell, 16(4), 367-372. <a
href="http://dx.doi.org/10.1016/j.stem.2015.02.0
05">[More Information]</a>
Hu, M., Kramer, B., Zhang, G., Wang, Y.,
Watson, D., Howden, B., McCowage, G.,
Alexander, I., Gunning, P., Alexander, S. (2015).
Methyl-Guanine-Methyl-Transferase Transgenic
Bone Marrow Transplantation Allows
N,N-bis(2-chloroethyl)-Nitrosourea Driven
Donor Mixed-Chimerism Without
Graft-Versus-Host Disease, and With
Donor-Specific Allograft Tolerance.
Transplantation, 99(12), 2476-2484. <a
href="http://dx.doi.org/10.1097/TP.00000000000
00825">[More Information]</a>
Cunningham, S., Siew, S., Hallwirth, C., Bolitho,
C., Sasaki, N., Garg, G., Michael, I.,
Hetherington, N., Carpenter, K., de Alencastro,
G., Alexander, I., et al (2015). Modeling
correction of severe urea cycle defects in the
growing murine liver using a hybrid recombinant
adeno-associated virus/piggyBac transposase
gene delivery system. Hepatology, 62(2),
417-428. <a
href="http://dx.doi.org/10.1002/hep.27842">[Mo
re Information]</a>
Alexander, I., Russell, D. (2015). The Potential
of AAV-Mediated Gene Targeting for Gene and
Cell Therapy Applications. Current Stem Cell
Reports, 1(1), 16-22. <a
href="http://dx.doi.org/10.1007/s40778-014-000
1-1">[More Information]</a>
Earl, J., Nath, C., Hanlon, M., Leach, C., Dale,
R., Logan, G., Alexander, I., Bishop, G. (2015).
The tryptophan damage signal and indoleamine
2, 3-dioxygenase. In Angel Catala (Eds.),
Indoleamines: Sources, role in biological
processes and health effects, (pp. 107-121). New
York: Nova Science Publishers, Inc.
Dane, A., Cunningham, S., Kok, C., Logan, G.,
Alexander, I. (2015). Transient suppression of
hepatocellular replication in the mouse liver
following transduction with recombinant
adeno-associated virus. Gene Therapy, 22(11),
917-922. <a
href="http://dx.doi.org/10.1038/gt.2015.66">[M
ore Information]</a>
2014
Deyle, D., Hansen, R., Cornea, A., Li, L., Burt,
A., Alexander, I., Sandstrom, R.,
Stamatoyannopoulos, J., Wei, C., Russell, D.
(2014). A genome-wide map of adeno-associated
virus-mediated human gene targeting. Nature
Structural and Molecular Biology, 21(11),
969-975. <a
href="http://dx.doi.org/10.1038/nsmb.2895">[M
ore Information]</a>
Logan, G., de Alencastro, G., Alexander, I.,
Yeoh, G. (2014). Exploiting the unique
regenerative capacity of the liver to underpin cell
and gene therapy strategies for genetic and
acquired liver disease. The International Journal
of Biochemistry and Cell Biology, 56, 141-152.
<a
href="http://dx.doi.org/10.1016/j.biocel.2014.10.
023">[More Information]</a>
Deakin, C., Deakin, J., Ginn, S., Young, P.,
Humphreys, D., Suter, C., Alexander, I.,
Hallwirth, C. (2014). Impact of next-generation
sequencing error on analysis of barcoded plasmid
libraries of known complexity and sequence.
Nucleic Acids Research, 42(16), 1-14. <a
href="http://dx.doi.org/10.1093/nar/gku607">[M
Publications for Ian Alexander
ore Information]</a>
Tay, S., Wong, Y., Roediger, B., Sierro, F., Lu,
B., McDonald, D., McGuffog, C., Meyer, N.,
Alexander, I., Parish, I., Weninger, W., Bishop,
A., Gamble, J., McCaughan, G., Bertolino, P.,
Bowen, D., et al (2014). Intrahepatic activation
of naive CD4+T cells by liver-resident
phagocytic cells. The Journal of Immunology,
193(5), 2087. <a
href="http://dx.doi.org/10.4049/jimmunol.14000
37">[More Information]</a>
Lisowski, L., Dane, A., Chu, K., Zhang, Y.,
Cunningham, S., Wilson, E., Nygaard, S.,
Grompe, M., Alexander, I., Kay, M. (2014).
Selection and evaluation of clinically relevant
AAV variants in a xenograft liver model. Nature,
506(7488), 382-386. <a
href="http://dx.doi.org/10.1038/nature12875">[
More Information]</a>
Ho, G., Alexander, I., Bhattacharya, K.,
Dennison, B., Ellaway, C., Thompson, S.,
Wilcken, B., Christodoulou, J. (2014). The
Molecular Bases of Phenylketonuria (PKU) in
New South Wales, Australia: Mutation Profile
and Correlation with Tetrahydrobiopterin (BH4)
Responsiveness. JIMD Reports, 14, 55-65. <a
href="http://dx.doi.org/10.1007/8904_2013_284"
>[More Information]</a>
Kojima, Y., Kaufman-Francis, K., Studdert, J.,
Steiner, K., Power, M., Loebel, D., Jones, V.,
Hor, A., de Alencastro, G., Logan, G.,
Alexander, I., Pickett, H., Tam, P., et al (2014).
The Transcriptional and Functional Properties of
Mouse Epiblast Stem Cells Resemble the
Anterior Primitive Streak. Cell Stem Cell, 14(1),
107-120. <a
href="http://dx.doi.org/10.1016/j.stem.2013.09.0
14">[More Information]</a>
2013
Cunningham, S., Kok, C., Spinoulas, A.,
Carpenter, K., Alexander, I. (2013).
AAV-encoded OTC activity persisting to
adulthood following delivery to newborn spfash
mice is insufficient to prevent shRNA-induced
hyperammonaemia. Gene Therapy, 20(12),
1184-1187. <a
href="http://dx.doi.org/10.1038/gt.2013.51">[M
ore Information]</a>
Kok, C., Cunningham, S., Carpenter, K., Dane,
A., Siew, S., Logan, G., Kuchel, P., Alexander, I.
(2013). Adeno-associated Virus-mediated
Rescue of Neonatal Lethality in
Argininosuccinate Synthetase-deficient Mice.
Molecular Therapy, 21(10), 1823-1831. <a
href="http://dx.doi.org/10.1038/mt.2013.139">[
More Information]</a>
Dane, A., Wowro, S., Cunningham, S.,
Alexander, I. (2013). Comparison of gene
transfer to the murine liver following
intraperitoneal and intraportal delivery of
hepatotropic AAV pseudo-serotypes. Gene
Therapy, 20(4), 460-464. <a
href="http://dx.doi.org/10.1038/gt.2012.67">[M
ore Information]</a>
Ginn, S., Alexander, I., Edelstein, M., Abedi, M.,
Wixon, J. (2013). Gene therapy clinical trials
worldwide to 2012 - an update. Journal of Gene
Medicine, 15(2), 65-77. <a
href="http://dx.doi.org/10.1002/jgm.2698">[Mor
e Information]</a>
Cunningham, E., Tay, S., Wang, C., Rtshiladze,
M., Wang, Z., McGuffog, C., Cubitt, J.,
McCaughan, G., Alexander, I., Bertolino, P.,
Sharland, A., Bowen, D., Bishop, A. (2013).
Gene therapy for tolerance: high-level expression
of donor major histocompatibility complex in the
liver overcomes naive and memory alloresponses
to skin grafts. Transplantation, 95(1), 70-77. <a
href="http://dx.doi.org/10.1097/TP.0b013e31827
8d39a">[More Information]</a>
Deakin, C., Alexander, I., Hooker, C., Kerridge,
I. (2013). Gene Therapy Researchers'
Assessments Of Risks And Perceptions Of Risk
Acceptability In Clinical Trials. Molecular
Therapy, 21(4), 806-815. <a
href="http://dx.doi.org/10.1038/mt.2012.230">[
More Information]</a>
Gerace, D., Ren, B., Hawthorne, W., Byrne, M.,
Phillips, P., O'Brien, B., Nassif, N., Alexander,
I., Simpson, A. (2013). Pancreatic
Transdifferentiation in Porcine Liver Following
Lentiviral Delivery of Human Furin-Cleavable
Insulin. Transplantation Proceedings, 45(5),
1869-1874. <a
href="http://dx.doi.org/10.1016/j.transproceed.20
13.01.051">[More Information]</a>
2012
El-Hoss, J., Sullivan, K., Cheng, T., Yu, N.,
Bobyn, J., Peacock, L., Mikulec, K., Baldock, P.,
Alexander, I., Schindeler, A., Little, D. (2012). A
murine model of neurofibromatosis type 1 tibial
pseudarthrosis featuring proliferative fibrous
tissue and osteoclast-like cells. Journal of Bone
and Mineral Research, 27(1), 68-78. <a
href="http://dx.doi.org/10.1002/jbmr.528">[Mor
e Information]</a>
Logan, G., Alexander, I. (2012).
Adeno-associated virus vectors: immunobiology
and potential use for immune modulation.
Current Gene Therapy, 12(4), 333-343. <a
href="http://dx.doi.org/10.2174/1566523128020
83639">[More Information]</a>
Alexander, I., Kok, C., Dane, A., Cunningham,
S. (2012). Gene therapy for metabolic disorders:
Publications for Ian Alexander
an overview with a focus on urea cycle disorders.
Journal of Inherited Metabolic Disease (JIMD),
35(4), 641-645. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=22403018">[More Information]</a>
Ginn, S., Alexander, I. (2012). Gene therapy:
Progress in childhood disease. Journal of
Paediatrics and Child Health, 48(6), 466-471. <a
href="http://dx.doi.org/10.1111/j.1440-1754.201
1.02204.x">[More Information]</a>
Chung, H., Lin, R., Logan, G., Alexander, I.,
Sachdev, P., Sidhu, K. (2012). Human Induced
Pluripotent Stem Cells Derived Under
Feeder-Free Conditions Display Unique Cell
Cycle and DNA Replication Gene Profiles. Stem
Cells and Development, 21(2), 206-216. <a
href="http://dx.doi.org/10.1089/scd.2010.0440">
[More Information]</a>
De Greef, E., Christodoulou, J., Alexander, I.,
Shun, A., O'Loughlin, E., Thorburn, D., Jermyn,
V., Stormon, M. (2012). Mitochondrial
Respiratory Chain Hepatopathies:
Role of Liver Transplantation. A Case Series of
Five Patients. JIMD Reports, 4, 5-12.
De Greef, E., Christodoulou, J., Alexander, I.,
Shun, A., O'Loughlin, E., Thorburn, D., Jermyn,
V., Stormon, M. (2012). Mitochondrial
Respiratory Chain Hepatopathies: Role of Liver
Transplantation. A Case Series of Five Patients.
In Society for the Study of Inborn Errors of
Metabolism (Eds.), JIMD Reports - Case and
Research Reports, 2012/1, (pp. 5-12). London:
Springer Science+Business Media.
Michot, C., Hubert, L., Romero, N., Gouda, A.,
Mamoune, A., Mathew, S., Kirk, E., Viollet, L.,
Rahman, S., Bekri, S., Alexander, I., et al (2012).
Study of LPIN1, LPIN2 and LPIN3 in
rhabdomyolysis and exercise-induced myalgia.
Journal of Inherited Metabolic Disease (JIMD),
35(6), 1119-1128. <a
href="http://dx.doi.org/10.1007/s10545-012-946
1-6">[More Information]</a>
2011
Both, G., Alexander, I., Fletcher, S., Nicolson,
T., Rasko, J., Wilton, S., Symonds, G. (2011).
Gene therapy: therapeutic applications and
relevance to pathology. Pathology, 43(6),
642-656. <a
href="http://dx.doi.org/10.1097/PAT.0b013e328
34b1dad">[More Information]</a>
Cunningham, S., Kok, C., Dane, A., Carpenter,
K., Kizana, E., Kuchel, P., Alexander, I. (2011).
Induction and Prevention of Severe
Hyperammonemia in the spf(ash) Mouse Model
of Ornithine Transcarbamylase Deficiency Using
shRNA and rAAV-mediated Gene Delivery.
Molecular Therapy, 19(5), 854-859. <a
href="http://dx.doi.org/10.1038/mt.2011.32">[M
ore Information]</a>
2010
Logan, G., Wang, L., Zheng, M., Coppel, R.,
Alexander, I. (2010). Antigen fusion with C3d(3)
augments or inhibits humoral immunity to AAV
genetic vaccines in a transgene-dependent
manner. Immunology and Cell Biology, 88(2),
228-232. <a
href="http://dx.doi.org/10.1038/icb.2009.92">[M
ore Information]</a>
Sharland, A., Logan, G., Bishop, A., Alexander,
I. (2010). Liver-directed gene expression using
recombinant AAV 2/8 vectors -- a tolerogenic
strategy for gene delivery? Discovery Medicine,
9(49), 519-527. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=20587341">[More Information]</a>
Ginn, S., Liao, S., Dane, A., Hu, M., Hyman, J.,
Finnie, J., Zheng, M., Cavazzana-Calvo, M.,
Alexander, S., Thrasher, A., Alexander, I.
(2010). Lymphomagenesis in SCID-X1 Mice
Following Lentivirus-mediated Phenotype
Correction Independent of Insertional
Mutagenesis and gammac Overexpression.
Molecular Therapy, 18(5), 965-976. <a
href="http://dx.doi.org/10.1038/mt.2010.50">[M
ore Information]</a>
Deakin, C., Alexander, I., Kerridge, I. (2010).
The ethics of gene therapy: Balancing the risks.
Current Opinion in Molecular Therapeutics,
12(5), 578-585. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=20886390">[More Information]</a>
2009
Cunningham, S., Spinoulas, A., Carpenter, K.,
Wilcken, B., Kuchel, P., Alexander, I. (2009).
AAV2/8-mediated Correction of OTC
Deficiency Is Robust in Adult but Not Neonatal
Spf(ash) Mice. Molecular Therapy, 17(8),
1340-1346. <a
href="http://dx.doi.org/10.1038/mt.2009.88">[M
ore Information]</a>
Deakin, C., Alexander, I., Kerridge, I. (2009).
Accepting risk in clinical research: is the gene
therapy field becoming too risk-averse?
Molecular Therapy, 17(11), 1842-1848. <a
href="http://dx.doi.org/10.1038/mt.2009.223">[
More Information]</a>
Logan, G., Wang, L., Zheng, M., Ginn, S.,
Coppel, R., Alexander, I. (2009).
Antigen-specific humoral tolerance or immune
augmentation induced by intramuscular delivery
of adeno-associated viruses encoding
Publications for Ian Alexander
CTLA4-Ig-antigen fusion molecules. Gene
Therapy (Basingstoke), 16(2), 200-210. <a
href="http://dx.doi.org/10.1038/gt.2008.168">[
More Information]</a>
Laurence, J., McCaughan, G., Logan, G.,
Alexander, I., Bishop, A., Sharland, A. (2009).
Gene therapy in transplantation. Transplantation
Reviews, 23(3), 159-170. <a
href="http://dx.doi.org/10.1016/j.trre.2009.04.00
1">[More Information]</a>
Cunningham, S., Zoccai, G., Spinoulas, A.,
Carpenter, K., Alexander, I. (2009). In vivo
assessment of mutations in OTC for
dominant-negative effects following
rAAV2/8-mediated gene delivery to the mouse
liver. Gene Therapy, 16(6), 820-823. <a
href="http://dx.doi.org/10.1038/gt.2009.38">[M
ore Information]</a>
Liu, R., Ginn, S., Lek, M., North, K., Alexander,
I., Little, D., Schindeler, A. (2009). Myoblast
sensitivity and fibroblast insensitivity to
osteogenic conversion by BMP-2 correlates with
the expression of Bmpr-1 a. BMC
Musculoskeletal Disorders, 10, 51-1-51-12. <a
href="http://dx.doi.org/10.1186/1471-2474-10-5
1">[More Information]</a>
Laurence, J., Wang, C., Zheng, M., Cunningham,
S., Earl, J., Tay, S., Allen, R., McCaughan, G.,
Alexander, I., Bishop, A., Sharland, A. (2009).
Overexpression of indoleamine dioxygenase in
rat liver allografts using a high-efficiency
adeno-associated virus vector does not prevent
acute rejection. Liver Transplantation, 15(2),
233-241. <a
href="http://dx.doi.org/10.1002/lt.21662">[More
Information]</a>
Dane, A., Cunningham, S., Graf, N., Alexander,
I. (2009). Sexually Dimorphic Patterns of
Episomal rAAV Genome Persistence in the
Adult Mouse Liver and Correlation With
Hepatocellular Proliferation. Molecular Therapy,
17(9), 1548-1554. <a
href="http://dx.doi.org/10.1038/mt.2009.139">[
More Information]</a>
2008
Curtin, J., Dane, A., Swanson, A., Alexander, I.,
Ginn, S. (2008). Bidirectional promoter
interference between two widely used internal
heterologous promoters in a late-generation
lentiviral construct. Gene Therapy (Basingstoke),
15(5), 384-390. <a
href="http://dx.doi.org/10.1038/sj.gt.3303105">[
More Information]</a>
Baoutina, A., Alexander, I., Rasko, J., Emslie, K.
(2008). Developing strategies for detection of
gene doping. Journal of Gene Medicine, 10,
3-20. <a
href="http://dx.doi.org/10.1002/jgm.1114">[Mor
e Information]</a>
Cunningham, S., Dane, A., Spinoulas, A.,
Alexander, I. (2008). Gene delivery to the
juvenile mouse liver using AAV2/8 vectors.
Molecular Therapy, 16(6), 1081-1088. <a
href="http://dx.doi.org/10.1038/mt.2008.72">[M
ore Information]</a>
Alexander, I., Cunningham, S., Logan, G.,
Christodoulou, J. (2008). Potential of AAV
vectors in the treatment of metabolic disease.
Gene Therapy, 15(11), 831-839. <a
href="http://dx.doi.org/10.1038/gt.2008.64">[M
ore Information]</a>
Lee, V., Wang, Y., Wang, Y., Zheng, D., Polhill,
T., Cao, Q., Wu, H., Alexander, I., Alexander, S.,
Harris, D. (2008). Regulatory immune cells in
kidney disease. American Journal of Physiology:
Renal Physiology, 295(2), F335-F342. <a
href="http://dx.doi.org/10.1152/ajprenal.00077.2
008">[More Information]</a>
2007
Cooper, S., Kizana, E., Yates, J., Lo, H., Yang,
N., Wu, Z., Alexander, I., North, K. (2007).
Dystrophinopathy carrier determination and
detection of protein deficiencies in muscular
dystrophy using lentiviral MyoD-forced
myogenesis. Neuromuscular Disorders, 17(4),
276-284. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17303423">[More Information]</a>
Kizana, E., Chang, C., Cingolani, E., Sekar, R.,
Ramirez-Correa, G., Abraham, M., Ginn, S.,
Tung, L., Alexander, I., Marban, E. (2007). Gene
transfer of connexin43 mutants attenuates
coupling in cardiomyocytes: novel basis for
modulation of cardiac conduction by gene
therapy. Circulation Research. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17495226">[More Information]</a>
Yu, Z., McKay, K., Van Asperen, P., Zheng, M.,
Fleming, J., Ginn, S., Kizana, E., Latham, M.,
Feneley, M., Kirkland, P., Lumbers, E.,
Alexander, I., et al (2007). Lentivirus
vector-mediated gene transfer to the developing
bronchiolar airway epithelium in the fetal lamb.
Journal of Gene Medicine, 9(6), 429-439. <a
href="http://dx.doi.org/10.1002/jgm.1039">[Mor
e Information]</a>
Smyth, C., Ginn, S., Deakin, C., Logan, G.,
Alexander, I. (2007). Limiting gammac
expression differentially affects signaling via the
interleukin (IL)-7 and IL-15 receptors. Blood,
110(1), 91-98. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
Publications for Ian Alexander
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17363735">[More Information]</a>
Ganesan, P., Alexander, S., Watson, D., Logan,
G., Zhang, G., Alexander, I. (2007). Robust
anti-tumor immunity and memory in
Rag-1-deficient mice following adoptive transfer
of cytokine-primed splenocytes and tumor CD80
expression. Cancer Immunology,
Immunotherapy: other biological response
modifications, 56(12), 1955-1965. <a
href="http://dx.doi.org/10.1007/s00262-007-033
9-7">[More Information]</a>
Deichmann, A., Hacein-Bey-Abina, S., Schmidt,
M., Garrigue, A., Brugman, M., Hu, J., Glimm,
H., Gyapay, G., Prum, B., et, A., Alexander, I.
(2007). Vector integration is nonrandom and
clustered and influences the fate of
lymphopoiesis in SCID-X1 gene therapy.
Journal of Clinical Investigation, 117(8),
2225-2232. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17671652">[More Information]</a>
2006
Logan, G., Wang, L., Zheng, M., Cunningham,
S., Coppel, R., Alexander, I. (2006). AAV
vectors encoding malarial antigens stimulate
antigen-specific immunity but do not protect
from parasite infection. Vaccine, 25(6),
1014-1022. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17081661">[More Information]</a>
Kramer, B., Lemckert, F., Alexander, I.,
Gunning, P., McCowage, G. (2006).
Characterisation of a P140K mutant
O(6)-methylguanine-DNA-methyltransferase
(MGMT)-expressing transgenic mouse line with
drug-selectable bone marrow. Journal of Gene
Medicine, 8(9), 1071-1085. <a
href="http://dx.doi.org/10.1002/jgm.937">[More
Information]</a>
Kizana, E., Ginn, S., Smyth, C., Boyd, A.,
Thomas, S., Allen, D., Ross, D., Alexander, I.
(2006). Fibroblasts modulate cardiomyocyte
excitability: implications for cardiac gene
therapy. Gene Therapy (Basingstoke), 13(22),
1611-1615. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16838030">[More Information]</a>
Wang, Y., Zhang, G., Wang, Y., Hu, M., Wu, H.,
Watson, D., Hori, S., Alexander, I., Harris, D.,
Alexander, S. (2006). Foxp3-transduced
polyclonal regulatory T cells protect against
chronic renal injury from adriamycin. Journal of
the American Society of Nephrology, 17(3),
697-706. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16467443">[More Information]</a>
Trent, R., Alexander, I. (2006). Gene therapy in
sport. British Journal of Sports Medicine, 40(1),
4-5. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16371483">[More Information]</a>
Hu, M., Kramer, B., Zhang, G., McCowage, G.,
Alexander, I., Gunning, P., Alexander, S. (2006).
Long term skin allograft survival in mice with
MGMT chimeric bone marrow engraftment.
Immunology and Cell Biology, 84 (Suppl.)(3),
A29-A29.
Hu, M., Kramer, B., Zhang, G., McCowage, G.,
Alexander, I., Gunning, P., Alexander, S. (2006).
Long term skin allograft survival in mice with
MGMT chimeric bone marrow engraftment. 24th
Annual Scientific Meeting of the Transplantation
Society of Australia and New Zealand (2006),
Australia: Nature Publishing Group.
2005
Alexander, I., Logan, G., Logan, G., Boadle, R.,
Rowe, P., Smythe, J. (2005). Differential
subcellular localization of CD86 in human
PBMC-derived macrophages and DCs, and
ultrastructural characterization by
immuno-electron microscopy. International
Immunology, 17(2), 123-132. <a
href="http://dx.doi.org/10.1093/intimm/dxh193"
>[More Information]</a>
Smyth, C., Logan, G., Boadle, R., Rowe, P.,
Smythe, J., Alexander, I. (2005). Differential
subcellular localization of CD86 in human
PBMC-derived macrophages and DCs, and
ultrastructural characterization by
immuno-electron microscopy. International
Immunology, 17(2), 123-132.
Kizana, E., Ginn, S., Allen, D., Ross, D.,
Alexander, I. (2005). Fibroblasts can be
genetically modified to produce excitable cells
capable of electrical coupling. Circulation,
111(4), 394-398. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15687125">[More Information]</a>
Kizana, E., Ginn, S., Smyth, C., Thomas, S.,
Allen, D., Ross, D., Alexander, I. (2005).
Fibroblasts Modulate Cardiomyocyte
Excitability:
Insights from Fibroblasts with Genetically
Altered Connexin43 Expression. Journal of Gene
Medicine, 7(point P8 on page 1127), 1127-1127.
Fleming, J., Spinoulas, A., Zheng, M.,
Cunningham, S., Ginn, S., McQuilty, R., Rowe,
Publications for Ian Alexander
P., Alexander, I. (2005). Partial correction of
sensitivity to oxidant stress in Friedreich ataxia
patient fibroblasts by frataxin-encoding
adeno-associated virus and lentivirus vectors.
Human Gene Therapy, 16(8), 947-956. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16076253">[More Information]</a>
Mitchell, J., Wilcken, B., Alexander, I., Ellaway,
C., O'Grady, H., Wiley, V., Earl, J.,
Christodoulou, J. (2005).
Tetrahydrobiopterin-responsive phenylketonuria:
The New South Wales experience. Molecular
Genetics and Metabolism, 86(Suppl 1), S81-S85.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16091307">[More Information]</a>
Ginn, S., Curtin, J., Kramer, B., Smyth, C.,
Wong, M., Kakakios, A., McCowage, G.,
Watson, D., Alexander, S., Latham, M., Rowe,
P., Alexander, I., et al (2005). Treatment of an
infant with X-linked severe combined
immunodeficiency (SCID-X1) by gene therapy
in Australia. Medical Journal of Australia,
182(9), 458-463. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15865589">[More Information]</a>
2004
Ginn, S., Smyth, C., Wong, M., Bennetts, B.,
Rowe, P., Alexander, I. (2004). A Novel
Splice-Site Mutation In The Common Gamma
Chain (Gammac) Gene Il2Rg Results In
X-Linked Severe Combined Immunodeficiency
With An Atypical Nk+ Phenotype. Human
Mutation, 23(5), 522-523.
Allen, D., Hardeman, E., North, K., Alexander,
I., Cooper, S., Maxwell, A., Kizana, E.,
Ghoddusi, M. (2004). C2C12 Co-Culture On A
Fibroblast Substratum Enables Sustained
Survival Of Contractile, Highly Differentiated
Myotubes With Peripheral Nuclei And Adult
Fast Myosin Expression. Cell Motility and the
Cytoskeleton, 58(3), 200-211. <a
href="http://dx.doi.org/10.1002/cm.20010">[Mo
re Information]</a>
Logan, G., Spinoulas, A., Alexander, S., Smythe,
J., Alexander, I. (2004). CD4 expression on EL4
cells as an epiphenomenon of retroviral
transduction and selection. Immunology and Cell
Biology, 82(2), 132-135.
Trent, R., Alexander, I. (2004). Gene Therapy:
Applications And Progress Towards The Clinic.
Internal Medicine Journal, 34(11), 621-625.
2003
Alexander, I., Kizana, E. (2003). Cardiac gene
therapy: therapeutic potential and current
progress. Current Gene Therapy: the
international journal for in-depth reviews on
gene therapy, 3(5), 418-451.
Fleming, J., Ginn, S., Alexander, I. (2003).
Dorsal root ganglia sensory neurons. In
Federico (Eds.), Lentivirus Gene Engineering
Protocols, (pp. 155-167). New Jersey: Humana
Press.
Ginn, S., Fleming, J., Curtin, J., Alexander, I.
(2003). Gene therapy: a roller-coaster ride.
Today's Life Science (Australia), 15(3), 26-29.
Hacein-Bey-Abina, S., Von Kalle, C., Schmidt,
M., McCormack, M., Wulffraat, N., Leboulch,
P., Lim, A., Osborne, C., Pawliuk, R., Morillon,
E., Alexander, I., et al (2003). LMO2-associated
clonal T Cell proliferation in two patients after
gene therapy for SCID-X1. Science, 302(5644),
415-419.
Ginn, S., Fleming, J., Rowe, P., Alexander, I.
(2003). Promoter interference mediated by the
U3 Region in early-generation HIV-1-Derived
Lentivirus Vectors can influence detection of
transgene expression in a cell-type and
species-specific manner. Human Gene Therapy,
14(12), 1127-1137.
2002
Alexander, I. (2002). Australasian Gene Therapy
Society kicks off. Journal of Gene Medicine, ,
4-4.
Logan, G., Smyth, C., Earl, J., Rowe, P., Zaikina,
I., Smythe, J., Alexander, I. (2002). HeLa cells
cocultured with periopheral blood lymphocytes
acquire an immuno-inhibitory phenotype through
up-regulation of indoleamine 2,3-dioxygenase
activity. Immunology, 105(4), 478-487.