Publications for Renae Ryan
Publications for Renae Ryan
2016
Ryan, R., Vandenberg, R. (2016). Elevating the
alternating-access model. Nature Structural and
Molecular Biology, 23(3), 187-189.
Cater, R., Ryan, R., Vandenberg, R. (2016). The
Split Personality of Glutamate Transporters: A
Chloride Channel and a Transporter.
Neurochemical Research, 41(3), 593-599. <a
href="http://dx.doi.org/10.1007/s11064-015-169
9-6">[More Information]</a>
2015
Vinh, N., Devine, S., Munoz, L., Ryan, R.,
Wang, B., Krum, H., Chalmers, D., Simpson, J.,
Scammells, P. (2015). Design, Synthesis, and
Biological Evaluation of Tetra-Substituted
Thiophenes as Inhibitors of p38α MAPK.
ChemistryOpen, 4(1), 56-64. <a
href="http://dx.doi.org/10.1002/open.201402076
">[More Information]</a>
McIlwain, B., Vandenberg, R., Ryan, R. (2015).
Transport rates of a glutamate transporter
homologue are influenced by the lipid bilayer.
The Journal of Biological Chemistry, 290(15),
9780-9788. <a
href="http://dx.doi.org/10.1074/jbc.M114.63059
0">[More Information]</a>
2014
href="http://dx.doi.org/10.1074/jbc.M114.56524
2">[More Information]</a>
Wang, K., Beaumont, K., Otte, N., Font Sadurni,
J., Bailey, C., van Geldermalsen, M., Sharp, D.,
Tiffen, J., Ryan, R., Jormakka, M., Haass, N.,
Rasko, J., Holst, J. (2014). Targeting glutamine
transport to suppress melanoma cell growth.
International Journal of Cancer, 135(5),
1060-1071. <a
href="http://dx.doi.org/10.1002/ijc.28749">[Mor
e Information]</a>
Cater, R., Vandenberg, R., Ryan, R. (2014). The
Domain Interface of the Human Glutamate
Transporter EAAT1 Mediates Chloride
Permeation. Biophysical Journal, 107(3),
621-629. <a
href="http://dx.doi.org/10.1016/j.bpj.2014.05.04
6">[More Information]</a>
2013
Carland, J., Edington, A., Scopelliti, A., Ryan,
R., Vandenberg, R. (2013). Directed
Mutagenesis in Structure Activity Studies of
Neurotransmitter Transporters. In David
Figurski (Eds.), Genetic Manipulation of DNA
and Protein - Examples from Current Research,
(pp. 167-184). Rijeka: InTech Publishers.
Ryan, R., Boudker, O. (2013). Glutamate
Transporter Family. In Gordon C. K. Roberts
(Eds.), Encyclopedia of Biophysics, (pp.
893-900). Heidelberg: Springer.
Vandenberg, R., Ryan, R., Carland, J., Imlach,
W., Christie, M. (2014). Glycine transport
inhibitors for the treatment of pain. Trends In
Pharmacological Sciences, 35(8), 423-430. <a
href="http://dx.doi.org/10.1016/j.tips.2014.05.00
6">[More Information]</a>
Vandenberg, R., Ryan, R. (2013). Mechanisms
of glutamate transport. Physiological Reviews,
93(4), 1621-1657. <a
href="http://dx.doi.org/10.1152/physrev.00007.2
013">[More Information]</a>
Carland, J., Handford, C., Ryan, R., Vandenberg,
R. (2014). Lipid Inhibitors of High Affinity
Glycine Transporters: Identification of a novel
class of analgesics. Neurochemistry
International, 73, 211-216. <a
href="http://dx.doi.org/10.1016/j.neuint.2013.08.
012">[More Information]</a>
Scopelliti, A., Ryan, R., Vandenberg, R. (2013).
Molecular Determinants for Functional
Differences between Alanine-Serine-Cysteine
Transporter 1 and Other Glutamate Transporter
Family Members. The Journal of Biological
Chemistry, 288(12), 8250-8257. <a
href="http://dx.doi.org/10.1074/jbc.M112.44102
2">[More Information]</a>
Wang, K., Grkovic, T., Font Sadurni, J.,
Bonham, S., Pouwer, R., Bailey, C., Moran, A.,
Ryan, R., Rasko, J., Jormakka, M., Holst, J., et al
(2014). Monoterpene Glycoside ESK246 from
Pittosporum Targets LAT3 Amino Acid
Transport and Prostate Cancer Cell Growth. ACS
Chemical Biology, 9(6), 1369-1376. <a
href="http://dx.doi.org/10.1021/cb500120x">[M
ore Information]</a>
Scopelliti, A., Heinzelmann, G., Kuyucak, S.,
Ryan, R., Vandenberg, R. (2014). Na+
interactions with the neutral amino acid
transporter. The Journal of Biological Chemistry,
289(25), 17468-17479. <a
Carland, J., Mansfield, R., Ryan, R.,
Vandenberg, R. (2013). Oleoyl-L-carnitine
inhibits glycine transport by GlyT2. British
Journal of Pharmacology, 168(4), 891-902. <a
href="http://dx.doi.org/10.1111/j.1476-5381.201
2.02213.x">[More Information]</a>
2012
Bastug, T., Heinzelmann, G., Kuyucak, S.,
Salim, M., Vandenberg, R., Ryan, R. (2012).
Position of the Third Na+ Site in the Aspartate
Transporter GltPh and the Human Glutamate
Transporter, EAAT1. PloS One, 7(3), 1-10. <a
href="http://dx.doi.org/10.1371/journal.pone.003
Publications for Renae Ryan
3058">[More Information]</a>
2008
2011
Vandenberg, R., Huang, S., Ryan, R. (2008).
Slips, leaks and channels in glutamate
transporters. Channels, 2(1), 51-58. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=18690049">[More Information]</a>
Bailey, C., Ryan, R., Theong, A., Ng, C., King,
K., Vanslambrouck, J., Auray-Blais, C.,
Vandenberg, R., Bröer, S., Rasko, J. (2011).
Loss-of-function mutations in the glutamate
transporter SLC1A1 cause human dicarboxylic
aminoaciduria. Journal of Clinical Investigation,
121(1), 446-453. <a
href="http://dx.doi.org/10.1172/JCI44474">[Mor
e Information]</a>
Vandenberg, R., Handford, C., Campbell, E.,
Ryan, R., Yool, A. (2011). Water and urea
permeation pathways of the human excitatory
amino acid transporter EAAT1. The Biochemical
Journal, 439(2), 333-340. <a
href="http://dx.doi.org/10.1042/BJ20110905">[
More Information]</a>
2010
McKinzie, A., Ryan, R., Vandenberg, R. (2010).
Site-Directed Mutagenesis in the Study of
Membrane Transporters. In Qing Yan (Eds.),
Membrane Transporters in Drug Discovery and
Development: Methods and Protocols - Methods
in Molecular Biology Volume 637, (pp.
277-293). New York: Humana Press.
Ryan, R., Kortt, N., Sirivanta, T., Vandenberg,
R. (2010). The position of an arginine residue
influences substrate affinity and K+ coupling in
the human glutamate transporter, EAAT1.
Journal of Neurochemistry, 114(2), 565-575. <a
href="http://dx.doi.org/10.1111/j.1471-4159.201
0.06796.x">[More Information]</a>
2009
Edington, A., McKinzie, A., Reynolds, A.,
Kassiou, M., Ryan, R., Vandenberg, R. (2009).
Extracellular loops 2 and 4 of GLYT2 are
required for N-arachidonylglycine inhibition of
glycine transport. Journal of Biological
Chemistry, 284(52), 36424-36430. <a
href="http://dx.doi.org/10.1074/jbc.M109.01750
9">[More Information]</a>
Ryan, R., Compton, E., Mindell, J. (2009).
Functional characterization of a Na+-dependent
aspartate transporter from Pyrococcus horikoshii.
Journal of Biological Chemistry, 284(26),
17540-17548. <a
href="http://dx.doi.org/10.1074/jbc.M109.00592
6">[More Information]</a>
Huang, S., Ryan, R., Vandenberg, R. (2009). The
Role of Cation Binding in Determining Substrate
Selectivity of Glutamate Transporters. Journal of
Biological Chemistry, 284(7), 4510-4515. <a
href="http://dx.doi.org/10.1074/jbc.M808495200
">[More Information]</a>
2007
Boudker, O., Ryan, R., Yernool, D., Shimamoto,
K., Gouaux, E. (2007). Coupling substrate and
ion binding to extracellular gate of a
sodium-dependent aspartate transporter. Nature,
445(7126), 387-393. <a
href="http://dx.doi.org/10.1038/nature05455">[
More Information]</a>
Ryan, R., Mindell, J. (2007). The uncoupled
chloride conductance of a bacterial glutamate
transporter homolog. Nature Structural and
Molecular Biology, 14(5), 365-371. <a
href="http://dx.doi.org/10.1038/nsmb1230">[Mo
re Information]</a>
2005
Ryan, R., Vandenberg, R. (2005). A channel in a
transporter. Clinical and Experimental
Pharmacology and Physiology, 32(1-2), 1-6. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15730426">[More Information]</a>
Vandenberg, R., Ryan, R. (2005). How and Why
Are Channels in Transporters? Signal
Transduction Knowledge Environment, 19(280),
pe17. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15840837">[More Information]</a>
2004
Vandenberg, R., Ju, P., Aubrey, K., Ryan, R.,
Mitrovic, A. (2004). Allosteric Modulation Of
Neurotransmitter Transporters At Excitatory
Synapses. European Journal of Pharmaceutical
Sciences, 23(1), 1-11.
Jennings, E., Ryan, R., Christie, M. (2004).
Effects Of Sumatriptan On Rat Medullary Dorsal
Horn Neurons. Pain, 111(1-2), 30-37.
Ryan, R., Mitrovic, A., Vandenberg, R. (2004).
The Chloride Permeation Pathway Of A
Glutamate Transporter And Its Proximity To The
Glutamate Translocation Pathway. Journal of
Biological Chemistry, 279(20), 20742-20751.
2003
Ryan, R., Mitrovic, A., Vandenberg, R. (2003).
Site-directed mutagenesis in the study of
membrane transportes. In Qing Yan (Eds.),
Membrane Transporters: Methods and Protocols
Publications for Renae Ryan
(Methods in Molecular Biology Vol. 227), (pp.
97-108). New Jersey, USA: Humana Press.
2002
Ryan, R., Vandenberg, R. (2002). Distinct
conformational states mediate the transport and
anion channel properties of the glutamate
transporter EAAT-1. Journal of Biological
Chemistry, 277(16), 13494-13500.
Borgland, S., Connor, M., Ryan, R., Ball, H.,
Christie, M. (2002). Prostaglandin E2 inhibits
calcium current in two sub-populations of
acutely isolated mouse trigeminal sensory
neurons. The Journal of Physiology, 539(2),
433-444.